MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Zein | Zein is a plant protein?based polymer, can be used to prepare nanofibrous mats through electrospun. Zein has good cell compatibility and easy fabrication ability, and can be used in drug delivery systems[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9010-66-6. Pack Sizes: 10 g; 25 g; 50 g. Product ID: HY-W763806. |  |
| Zelasudil | Zelasudil (RXC007) is an orally active, highly selective small molecule Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor with anti-fibrotic efficacy. Zelasudil elicits positive immunomodulatory effects in metastatic pancreatic tumors with increase of CD8+ and CD4+ T cell infiltrate into the tumor cortex and reduction in immunosuppressive FOXP3+ regulatory T cells at the tumor border. Zelasudil is promising for research of pancreatic ductal adenocarcinoma[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RXC007. CAS No. 2365193-22-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-148808. | |
| Zelatriazin | Zelatriazin (TAK-041; NBI-1065846) is a potent and selective GPR139 agonist with an EC50 of 22 nM. Zelatriazin has the potential for the research of negative symptoms associated with schizophrenia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAK-041; NBI-1065846. CAS No. 1929519-13-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132228. | |
| Zelavespib | Zelavespib (PU-H71) is a potent Hsp90 inhibitor, with an IC50 of 51 nM in MDA-MB-468 cells. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PU-H71. CAS No. 873436-91-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11038. | |
| Zelebrudomide | Zelebrudomide (NX-2127) (Compound 28) is an orally active PROTAC deggrader, targeting to Brutons Tyrosine Kinase (Btk). Zelebrudomide inhibits proliferation of BTKC481S mutant TMD8 cells, more effectively than Ibrutinib (HY-10997). Zelebrudomide catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with of 25 nM and 54 nM, respectively. Zelebrudomide stimulates T cell activation and increases IL-2 production in primary human T Cells[1][2]. (Pink: BTK ligand 10 (HY-168302); Black: (R)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline (HY-168348); Blue: Thalidomide 5-fluoride (HY-W087383). Uses: Scientific research. Category: Signaling pathways. Alternative Names: NX-2127. CAS No. 2416131-46-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-153220. | |
| Zelenirstat | Zelenirstat is an orally acitve, small-molecule, dual N-myristoyltransferase (NMT) inhibitor, with IC50s of 5 nM (NMT1) and 8 nM (NMT2), respectively. Zelenirstat can induce cell apoptosis, has anti-cancer activity, inhibits early B cell receptor (BCR) signaling, and can be used to study malignant lymphoma[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PCLX-001. CAS No. 1215011-08-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147308. | |
| Zelicapavir | Zelicapavir (RSV-IN-7) (example 253) is an orally active RSV inhibitor (EC50: < 0.4 μΜ)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EDP-938; RSV-IN-7. CAS No. 2070852-76-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147346. | |
| Zelminemab | Zelminemab (AMG-301) is a humanized monoclonal antibody that inhibits PACAP type I (PAC1) receptor[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG-301. CAS No. 2225850-33-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99509. | |
| Zelnecirnon | Zelnecirnon (RPT193) is an orally active inhibitor of CCR4, blocks the recruitment of Th2 inflammatory immune cells into inflamed tissues. Zelnecirnon can be used for allergic inflammation in atopic dermatitis, asthma, and other diseases research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RPT193. CAS No. 2366152-15-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148074. | |
| Zeltociclib | Zeltociclib is a cyclin-dependent kinase inhibitor with antitumor effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2789697-52-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172245. | |
| ZEN-3219 | ZEN-3219 is a BET inhibitor with IC50s of 0.48, 0.16 and 0.47 μM for BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2), respectively. ZEN-3219 can be used to form PROTACs to induce degradation of BRD4[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1952264-34-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111977. | |
| ZEN-3862 | ZEN-3862 is a BET inhibitor with IC50s of 0.16 and 0.13 μM for BRD4(BD1) and BRD4(BD2) , respectively. ZEN-3862 can be used to form PROTACs to induce degradation of BRD4[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1952264-33-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-111978. | |
| Zenarestat | Zenarestat is a potent and orally active aldose reductase inhibitor. Zenarestat improves diabetic peripheral neuropathy in Zucker diabetic fatty rats[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 112733-06-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116239. | |
| Zenidolol | Zenidolol (ICI-118551) is a selective β2-adrenergic receptor antagonist with Ki values of Zenidolol for β2, β1 and β3 adrenergic receptors of 0.7, 49.5 and 611 nM, respectively. Zenidolol exerts antitumor effects via inducing apoptosis, inhibiting tumor sphere formation, and downregulating the HIF pathway by blocking β2-AR on tumor cells. Zenidolol exhibits a unique pulmonary vessel-specific vasodilatory effect in mouse models. Zenidolol can be used as an intraocular pressure-lowering agent in ophthalmic disease research[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ICI-118551. CAS No. 72795-26-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100543. | |
| Zenidolol hydrochloride | Zenidolol (ICI-118551) hydrochloride is a highly selective β2 adrenergic receptor antagonist, with Kis of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ICI-118551 hydrochloride. CAS No. 72795-01-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13951. | |
| Zenocutuzumab | Zenocutuzumab (MCLA-128) is a bispecific humanized IgG1 antibody containing two different Fab arms, targeting extracellular domains of HER2 and HER3[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MCLA-128; PB4188; R040517. CAS No. 1969309-56-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99507. | |
| Zeranol | Zeranol, a metabolite of the mycoestrogen zearalenone, is an estrogen receptor agonist. Zeranol is used as a growth promoter of livestock due to its strong estrogenic activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: α-Zearalanol. CAS No. 26538-44-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-N6709. | |
| Zerencotrep | Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (-)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pico145; HC-608. CAS No. 1628287-16-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-101507. | |
| Zervimesine | Zervimesine (CT1812) is an orally active and brain penetrant sigma-2 receptor antagonist with a Ki of 8.5 nM. Zervimesine can be used for the research of Alzheimers disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CT1812; Sigma-2 receptor antagonist 1. CAS No. 1802632-22-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-111669. | |
| ζ-Stat trisodium | ζ-Stat trisodium (NSC37044 trisodium) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat trisodium can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC37044 trisodium. CAS No. 31894-34-5. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-123979A. | |
| Zeteletinib | Zeteletinib (BOS-172738; DS-5010) is an orally active, selective RET kinase inhibitor with nanomolar potency against RET and >300-fold selectivity against VEGFR2. Zeteletinib shows exquisite potency for the wild type RET, RETV804M/L gatekeeper mutants, and the most common oncogenic RET mutation M918T. Zeteletinib has potent antitumor activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BOS-172738; DS-5010. CAS No. 2216753-97-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139590. | |
| Zetomipzomib | Zetomipzomib (KZR-616), a first-in-class inhibitor of the immunoproteasome, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome. Zetomipzomib has the potential for the research of multiple autoimmune diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KZR-616. CAS No. 1629677-75-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-114419. | |
| Zevotrelvir | Zevotrelvir (EDP-235) is a coronavirus inhibitor that can inhibit 229E hCoV and the SARS-CoV-2 3C-like (3CL) protease (IC50 <0.1 mM). Zevotrelvir can be used in research on coronavirus infections[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EDP-235. CAS No. 2773516-53-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156651. | |
| Z-FA-FMK | Z-FA-FMK ((1S)-Z-FA-FMK) is a potent Cathepsin B and L inhibitor. Z-FA-FMK blocks the induction of DEVDase activity, DNA fragmentation, and externalization of phosphatidylserine by selective synthetic retinoid-related molecules (RRMs). Z-FA-FMK inhibits apoptosis. Z-FA-FMK inhibits caspase activity and selectively inhibits recombinant effector caspases 2, -3, -6, and -7. Z-FA-FMK is a viral inhibitor. Z-FA-FMK inhibits reovirus replication in a susceptible host[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (1S)-Z-FA-FMK. CAS No. 197855-65-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0109A. | |
| Z-FF-FMK | Z-FF-FMK (Z-Phe-Phe-FMK) is a cell-permeable, irreversible, and cysteine protease inhibitor targeting cathepsin-L. Z-FF-FMK inhibits angiotensin II-induced MEK activation in vascular walls, aortic medial remodeling, blood pressure elevation, and upregulation of cystatin C in aortic walls. Z-FF-FMK prevents β-amyloid-mediated caspase-3 activation, poly (ADP-ribose) polymerase cleavage, DNA fragmentation, and apoptosis of cortical neurons (apoptosis). Z-FF-FMK can be used in research related to hypertension and Alzheimer's disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Z-Phe-Phe-FMK. CAS No. 105608-85-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-141867. | |
| Z-FY-CHO | Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific cathepsin L (CTSL) inhibitor[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Z-Phe-Tyr-CHO. CAS No. 167498-29-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-128140. | |
| ZG-2291 | ZG-2291 is a selective inhibitor targeting FIH (Factor Inhibiting HIF) with oral activity. By binding to FIH, ZG-2291 promotes a conformational flip of a catalytically important tyrosine, enabling selective inhibition of FIH without affecting other 2OG oxygenases in the JmjC subfamily. ZG-2291k enhances thermogenesis in ob/ob mice and improves obesity-related symptoms and metabolic dysfunctions. ZG-2291 holds promise for research in the field of obesity-related diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2962103-40-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-159120. | |
| ZG-2305 | ZG-2305 is a potent, orally active and selective factor inhibiting hypoxia-inducible factor (FIH) inhibitor with Ki values of 79.6, 2786 nM for FIH, PHD2, respectively. ZG-2305 increases the expression of EGLN3 gene. ZG-2305 decreases the cellular triglycerides levels and reduces lipid accumulation. ZG-2305 has the potential for the research of obesity and fatty liver disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2962103-54-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-168533. | |
| Z-Gly-Arg-Thiobenzyl ester | Z-Gly-Arg-Thiobenzyl ester is a chromogenic substrate for plasmogen-activated serine proteases[1]. Uses: Scientific research. Category: Peptides. CAS No. 130698-88-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5278. | |
| Z-Gly-Gly-Arg-AMC | Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate for testing of thrombin generation in PRP and platelet-poor plasma (PPP) (Ex/Em = 390/480 nm)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 66216-78-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0019. | |
| Z-Gly-Pro-AMC | Z-Gly-Pro-AMC is a fluorogenic substrate. Z-Gly-Pro-AMC is hydrolyzed by prolyl endopeptidase to generate highly fluorescent 7-Amino-4-methylcoumarin (HY-D0027). (λex=380 nm, λem=465 nm)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 68542-93-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1670. | |
| Z-Gly-Pro-Arg-AMC hydrochloride | Z-Gly-Pro-Arg-AMC hydrochloride a fluorescent trypsin and cathepsin K substrate. Z-Gly-Pro-Arg-AMC hydrochloride can be used to determine trypsin and cathepsin K activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 201928-42-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4217. | |
| Z-Gly-Pro-pNA | Z-Gly-Pro-pNA is a substrate for measuring prolyl endopeptidase (PEP) inhibitory activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 65022-15-3. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-137220. | |
| (Z)-Guggulsterone | (Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF-VEGF-R2-Akt signaling axis[1]. (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 39025-23-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110066. | |
| Zharp1-211 | Zharp1-211 is a RIPK1 kinase inhibitor with an EC50 of 53 nM and a Kd of 8.7 nM. Zharp1-211 reduces IFN-γ-induced STAT1 activation. Zharp1-211 can be used in the research of graft-versus-host disease and colon cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2258671-41-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161060. | |
| Zharp2-1 | Zharp2-1 is an oral effective RIPK2 inhibitor, highly associated with inflammatory bowel disease (IBD). Zharp2-1 blocker muramyl dipeptide (MDP) induces growth of mononuclear cells and induces inflammatory cell factor infection. Zharp2-1 attenuates MDP-induced small inguinal peritonitis, or ameliorates by DNBS-induced large inguinal conjunctivitis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2772600-18-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155782. | |
| ZHAWOC8655 | ZHAWOC8655 is a USP18 inhibitor with a IC50 of 14.1 μM against hUSP18. ZHAWOC8655 disrupts the intracellular binding of USP18/ISG15[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1257657-02-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172969. | |
| Ziapin 2 | Ziapin 2 is a membrane potential modulator and an intracellular membrane photoactuator. Ziapin 2 binds to the bacterial plasma membrane, and upon embedding into the lipid bilayer, undergoes trans-cis isomerization under 470 nm light irradiation, which triggers membrane potential hyperpolarization and induces the opening of ion channels on bacterial cell membranes. Through interactions with lipids, Ziapin 2 increases the overall flexibility of the lipid bilayer. Ziapin 2 can form photosensitive transmembrane dimers to trigger cellular signal transduction. Ziapin 2 is applicable to the research and regulation of bacterial electrical signal transduction and the regulation of membrane physical properties[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2399497-60-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-156004. | |
| Zibotentan | Zibotentan (ZD4054) is a potent, selective and orally active endothelin A (ETA) receptor antagonist with a Ki of 13 nM. Zibotentan has no inhibitory effect on ETB. Zibotentan has anticancer effects and can be used for castration-resistant prostate cancer (CRPC) research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ZD4054. CAS No. 186497-07-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10088. | |
| Ziconotide acetate | Ziconotide acetate (SNX-111 acetate), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide acetate reduces synaptic transmission, and can be used for chronic pain research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SNX-111 acetate. CAS No. 914454-03-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0062B. | |
| Zidebactam | Zidebactam (WCK-5107) is a potent β-lactamase inhibitor[1]. Zidebactam also is a penicillin-binding protein2 (PBP2) inhibitor with an IC50 of 0.26 μg/mL[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WCK-5107. CAS No. 1436861-97-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120859. | |
| Zidesamtinib | Zidesamtinib (NVL-520) is a potent, selective, orally active and brain-penetrant inhibitor of diverse ROS1 fusions and resistance mutations, with IC50s of 0.7 and 7.9 nM for wild-type ROS1 and ROS1 G2032R, respectively, and spares TRK inhibition. Zidesamtinib can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NVL-520; NUV-520. CAS No. 2739829-00-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152292. | |
| Zidovudine | Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Azidothymidine; AZT; ZDV. CAS No. 30516-87-1. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-17413. | |
| Zidovudine O-β-D-glucuronide sodium | Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium. CAS No. 133525-01-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-137522. | |
| Zidovudine (Standard) | Zidovudine (Standard) is the analytical standard of Zidovudine. This product is intended for research and analytical applications. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Azidothymidine (Standard); AZT (Standard); ZDV (Standard). CAS No. 30516-87-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17413R. | |
| Z-IETD-FMK | Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective and cell permeable caspase-8 inhibitor[1]. Z-IETD-FMK is also a granzyme B inhibitor[5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Z-IE(OMe)TD(OMe)-FMK. CAS No. 210344-98-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101297. | |
| ZIF-14 | ZIF-14 is a metal-organic framework (MOF). Uses: Scientific research. Category: Signaling pathways. CAS No. 945215-37-2. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W075516. | |
| ZIF-67(Co) | ZIF-67(Co) (Monocobalt(II) bis(2-methyl-1H-imidazole)) is a metal-organic framework (MOF). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Monocobalt(II) bis(2-methyl-1H-imidazole); Cobalt 2-methylimidazole (ZIF-67). CAS No. 46201-07-4. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W075515. | |
| ZIF-8 | ZIF-8 (2-Methylimidazole zinc salt) is a pyroptosis inducer that activates the caspase-1/gasdermin D-dependent pyroptosis pathway. ZIF-8 induces pyroptotic cell death accompanied by necrosis and immunogenic cell death. ZIF-8 initiates in situ immunity, activates anti-tumor immunity, and reprograms the immunosuppressive tumor microenvironment to inhibit tumor growth. ZIF-8 acts as a pH-responsive and stimulus-responsive drug release inducer. ZIF-8 is applicable to cancer-related research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Methylimidazole zinc salt. CAS No. 59061-53-9. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-W075517. | |
| Zifogaptide | Zifogaptide is a gap junction protein channel regulator. Zifogaptide mimics the PDZ-binding motif at the C-terminal of Claudin C and competitively interferes with the interaction between Claudin-TJP1 (ZO-1) scaffold. Zifogaptide can promote epithelial cell migration, reduce scar formation, and accelerate wound healing. Zifogaptide can be used for radiation dermatitis, skin injuries, etc[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1465809-36-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10886. | |
| Ziftomenib | Ziftomenib (KO-539) is an orally active menin-MLL interaction inhibitor with antitumor activities (WO2017161028A1, compound 151)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KO-539. CAS No. 2134675-36-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132001. | |
| Zigakibart | Zigakibart (BION-1301) is an IgG4-kappa, humanized monoclonal antibody against TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256). Zigakibart exhibits anti-inflammatory activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BION-1301. CAS No. 2642175-46-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990070. | |
| Zileuton | Zileuton is a potent and selective inhibitor of 5-lipoxygenase with antiasthmatic properties. Uses: Scientific research. Category: Signaling pathways. Alternative Names: A 64077; Abbott 64077. CAS No. 111406-87-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14164. | |
| Zileuton sodium | Zileuton sodium (A 64077 sodium) is a potent and selective inhibitor of 5-lipoxygenase, exhibiting inflammatory activities. Uses: Scientific research. Category: Signaling pathways. Alternative Names: A 64077 sodium; Abbott 64077 sodium. CAS No. 118569-21-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14164A. | |
| Zilovertamab | Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UC-961; Cirmtuzumab. CAS No. 2485779-13-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99201. | |
| Ziltivekimab | Ziltivekimab (COR-001) is a fully human monoclonal antibody and also an IL-6 inhibitor. Ziltivekimab significantly reduces inflammatory biomarkers and Lipoprotein (a) in chronic kidney disease patients with systemic inflammation. Ziltivekimab does not increase pro-atherosclerotic lipid levels. Ziltivekimab is used in studies related to atherosclerotic thrombotic diseases and chronic kidney disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: COR-001; MEDI-5117; MEDI-5117; NN-6018; WBP-216. CAS No. 2226654-05-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99505. | |
| Zilucoplan | Zilucoplan (RA101495), a 15-amino acid macrocyclic peptide, is a potent complement component 5 (C5) inhibitor. Zilucoplan can be used in research of immune-mediated necrotising myopathy (IMNM)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RA101495; RA3193. CAS No. 1841136-73-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3502. | |
| Zilurgisertib | Zilurgisertib (INCB-000928; NBU-928) is a selective ALK2 inhibitor with an IC50 value of 15 nM. Zilurgisertib inhibits SMAD1/5 phosphorylation with an IC50 value of 63 nM. Zilurgisertib inhibits hepcidin production and improve anemia. Zilurgisertib can be used in melanoma research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INCB-000928; NBU-928. CAS No. 2173389-57-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145608. | |
| Zilvetrigine | Zilvetrigine is a sodium channel blocker. Zilvetrigine can be used as analgesics[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3002072-52-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-172246. | |
| ZIM | ZIM, a norbornene derived from 4-Aminoantipyrine, is a potent inducer of DNA damage, causing genomic and chromosomal damage as well as inducing cell death and activating phagocytosis. ZIM has chemotherapeutic potential for use in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 301298-87-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152246. | |
| Zimelidine dihydrochloride | Zimelidine dihydrochloride is an orally active selective serotonin reuptake inhibitor. Zimelidine dihydrochloride competitively inhibits central 5-HT uptake and desensitizes 5-HT autoreceptors in dorsal raphe nucleus. Zimelidine dihydrochloride time-dependently modulates 5-HT neuronal firing and hippocampal CA3 responses. Zimelidine dihydrochloride strengthens central serotonergic neurotransmission and produces related behavioral changes. Zimelidine dihydrochloride exerts anxiolytic, analgesic, feeding-suppressive and tolerance-attenuating effects. Zimelidine dihydrochloride is used for the study of depressive disorders and analgesic tolerance[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 60525-15-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110023. | |
| Zimlovisertib | Zimlovisertib (PF-06650833) is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC50s of 0.2 and 2.4 nM in the cell and PBMC assay, respectively. Zimlovisertib is used to treat diseases such as rheumatoid arthritis, lupus, and lymphomas[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-06650833. CAS No. 1817626-54-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-19836. | |
| ZINC00640089 | ZINC00640089 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00640089 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00640089 has good potential for research in inflammatory breast cancer (IBC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 667880-11-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-Q45780. | |
| ZINC00784494 | ZINC00784494 is a specific Lipocalin-2 (LCN2) inhibitor. ZINC00784494 inhibits cell proliferation, cell viability and reduces AKT phosphorylation levels in SUM149 cells. ZINC00784494 has good potential for research in inflammatory breast cancer (IBC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 317328-17-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148364. | |
| ZINC03129319 | ZINC03129319 is a dengue virus (DENV) NS2B-NS3 protease inhibitor extracted from patent US20150141521A1, has inhibition constants (Ki1) of 92 μM and Ki3 of 20 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1777807-64-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-112254. | |
| ZINC05007751 | ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. ZINC05007751 shows antiproliferative activity against a panel of human cancer cell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2, NEK7, and NEK9[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 591239-68-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122639. | |
| ZINC12409120 | ZINC12409120 is a high selective ERK inhibitor. ZINC12409120 acts on disrupting FGF23:α-Klotho interaction to inhibit ERK activity with an IC50 of 5.0 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1010888-06-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150687. | |
| ZINC40099027 | ZINC40099027 is a selective FAK activator. ZINC40099027 promotes FAK phosphorylation, without activating its paralogs Pyk2 and Src. ZINC40099027 promotes the wound closure of human intestinal epithelial monolayers and the healing of mouse ulcers by activating FAK. ZINC40099027 can be used for diseases related to gastrointestinal mucosal injury research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1211825-25-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134570. | |
| ZINC49534341 | ZINC49534341 is a MRGPRX2 antagonist, with a Ki of 32 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1274013-03-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-156907. | |
| ZINC69391 | ZINC69391, a specific Rac1 inhibitor, interferes with Rac1-GEF interaction by masking Trp56 residue on Rac1 surface. ZINC69391 interferes with the interaction of Rac1 with Dock180 and reduces Rac1-GTP levels. ZINC69391 induces apoptosis, and shows antiproliferative and antimetastatic effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 303094-67-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102078. | |
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