BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Vandetanib hydrochloride | Vandetanib hydrochloride is an anti-cancer drug that is used for the treatment of certain tumours of thethyroid gland. It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor (VEGFR), the epidermal growth factor receptor (EGFR), and the RET-tyrosine kinase. Synonyms: Zactima hydrochloride; ZD6474 hydrochloride; ZD 6474 hydrochloride; ZD-6474 hydrochloride. Grades: >98%. CAS No. 524722-52-9. Molecular formula: C22H25BrClFN4O2. Mole weight: 511.81. |  |
| Vandetanib trifluoroacetate | Vandetanib is an anti-cancer drug that is used for the treatment of certain tumours of thethyroid gland. It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor (VEGFR), the epidermal growth factor receptor (EGFR), and the RET-tyrosine kinase. Synonyms: Zactima trifluoroacetate; ZD6474 trifluoroacetate; ZD-6474 trifluoroacetate; ZD 6474 trifluoroacetate. Grades: >98%. CAS No. 338992-53-3. Molecular formula: C24H25BrF4N4O4. Mole weight: 589.38. | |
| Vaniprevir | Vaniprevir is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease. It is a macrocyclic hepatitis C virus NS3/4a protease inhibitor, and is active against both the genotype 1 and genotype 2 NS3/4a protease enzymes. It has good plasma exposure and excellent liver exposure in multiple species. Synonyms: MK7009; MK-7009; MK 7009; Vaniprevir. Grades: >98%. CAS No. 923590-37-8. Molecular formula: C38H55N5O9S. Mole weight: 757.94. | |
| Vardenafil dihydrochloride | Vardenafil, also called as Levitra and Nuviva, is a phosphodiesterase inhibitor that is selective for PDE5 and PDE1 (IC50 = 0.7 and 180 nM, respectively). Uses: A selective phsphodiesterase type 5 (pde5) inhibitor. Synonyms: BAY 38-9456; BAY-38-9456; BAY38-9456; Vardenafil HCl; 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one;dihydrochloride; 1-(((3-(3,4-dihydro-5-methyl)-4-oxo-7-propylimidazo(5,1-f)-as-triazin-2-yl)-4-ethoxyphenyl)sulfonyl)-4-ethylpiperazine; Anhydrous, Vardenafil Hydrochloride; Dihydrochloride, Vardenafil; Hydrochloride Anhydrous, Vardenafil; Levitra; vardenafil. Grades: >98%. CAS No. 224789-15-5. Molecular formula: C23H34Cl2N6O4S. Mole weight: 561.523. | |
| Varenicline Hydrochloride | Varenicline(CP 526555; Champix; Chantix) is a prescription medication used to treat smoking addiction. As a partial agonist it both reduces cravings for and decreases the pleasurable effects of cigarettes and other tobacco products. Through these mechanisms Varenicline(CP 526555; Champix; Chantix) can assist some patients to quit smoking. Synonyms: CP 526555 hydrochloride; CP526555 hydrochloride; CP-526555 hydrochloride; Champix hydrochloride; Chantix hydrochloride. Grades: >98%. CAS No. 230615-23-3. Molecular formula: C13H14ClN3. Mole weight: 247.72. | |
| Varespladib | Varespladib is a potent and selective inhibitor of secretory phospholipase A2 (sPLA2). The compound Varespladib inhibits both human and mouse sPLA2 group IIA, V, and X enzymes at low nM concentrations. Synonyms: LY315920; LY-315920; LY 315920; A-002; A002; A 002; Varespladib. Grades: >98%. CAS No. 172732-68-2. Molecular formula: C21H20N2O5. Mole weight: 380.39. | |
| varlilumab | A human agonistic monoclonal antibody (MoAb) specific for CD27, with potential immunostimulating and antineoplastic activity. Synonyms: CDX 1127; CDX-1127; CDX1127; UNII-0125DUV5XC. CAS No. 1393344-72-3. Molecular formula: C6486H9992N1740O2022S42. | |
| Varlitinib | Varlitinib, also known as ARRY-543, is an orally bioavailable inhibitor of the epidermal growth factor receptor family with potential antineoplastic activity. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types. Due to the dual inhibition of both EGFR and Her-2, this agent may be therapeutically more effective than agents that inhibit EGFR or Her-2 alone. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). (last updated ). Synonyms: code name: AR 00334543; ARRY-334543; ARRY334543; ARRY-543; ARRY543; ARRY 543. Grades: 0.99. CAS No. 845272-21-1. Molecular formula: C22H19ClN6O2S. Mole weight: 466.944. | |
| VAS2870 | VAS2870 is a cell-permeable and selective inhibitor of the NADPH oxidases. It was shown to enhance apoptosis induced by a physiological stimulus, such as TGF-β, and inhibit either autocrine or serum-dependent cell growth in several human HCC cell lines. Synonyms: VAS-2870; VAS 2870; 2-(3-Benzyltriazolo[4,5-d]pyrimidin-7-yl)sulfanyl-1,3-benzoxazole. Grades: ≥98%. CAS No. 722456-31-7. Molecular formula: C18H12N6OS. Mole weight: 360.4. | |
| Vasopressin antagonist 1867 | Vasopressin antagonist 1867 is a selective vasopressin 1B (V1b) receptor antagonist (IC50 value 3 nM for hV1b inhibition, exhibiting >1000-fold selectivity over hV1a, hV2, and hOT). Synonyms: Vasopressin antagonist 1867; 909391-88-4; CHEMBL1684573; 2-[2-(3-methoxyphenyl)-4-oxo-6-(3-piperidin-1-ylpropoxy)quinazolin-3-yl]-N-propan-2-ylacetamide; N-isopropyl-2-(2-(3-methoxyphenyl)-4-oxo-6-(3-(piperidin-1-yl)propoxy)quinazolin-3(4H)-yl)acetamide; Compound 12i; SCHEMBL3114804; BDBM50338810. Grades: 99%. CAS No. 909391-88-4. Molecular formula: C28H36N4O4. Mole weight: 492.61. | |
| Vatalanib dihydrochloride | Vatalanib (PTK787; ZK-222584; CGP-79787) is an inhibitor of VEGFR2/KDR with IC50 of 37 nM, less potent against VEGFR1/Flt-1, 18-fold against VEGFR3/Flt-4. Uses: Protein kinase inhibitors. Synonyms: PTK787; PTK 787; PTK-787; ZK 222584; ZK222584; ZK-222584; CGP 79787; CGP-797870; ZK-232934; CGP79787D; PTK787/ZK 222584; CGP-7978. nchembio778-comp1; PTK/ZK; D06285; CGP79787D; PTK787/ZK 222584. Grades: 0.98. CAS No. 212141-51-0. Molecular formula: C20H15ClN4.2HCl. Mole weight: 419.73. | |
| Vatalanib succinate | Vatalanib succinate is a potent and orally bioactive VEGFR inhibitor (IC50 = 37 and 77 nM for VEGFR-2 and -1, respectively) exhibiting potential antineoplastic activity. Vatalanib binds to the protein kinase domain of VEGFR, and inhibits proliferation, migration and survival of HUVECs in vitro. Vatalanib also inhibits PDGFR-β, c-Kit and c-Fms. Synonyms: N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate; CGP 79787D; PTK 787; ZK 222584; CGP79787D; PTK787; ZK222584; CGP-79787D; PTK-787; ZK-222584. Grades: ≥99% by HPLC. CAS No. 212142-18-2. Molecular formula: C20H15ClN4.C4H6O4. Mole weight: 464.9. | |
| VBY-825 | VBY-825 is a potent inhibitor of the assayed cathepsins and its potency against at least one cathepsin, cathepsin S, extends across species relevant for pharmacology studies, specifically mouse. 10 mg/kg/day dose of VBY-825 achieves a trough plasma concentration >200nM, which is well above that required for full inhibition of the intracellular activity of cathepsins B, F, K, L, S and V in both mouse and human cell lines. Synonyms: VBY-825; VBY 825; VBY825. Grades: >98%. CAS No. 1310340-58-9. Molecular formula: C23H29F4N3O5S. Mole weight: 535.55. | |
| VCH-286 | VCH-286 is a C-C chemokine receptor 5 (CCR5) receptor antagonist, which can be used to treat HIV infection. Synonyms: VCH 286; VCH286; AC-31386. Grades: ≥98% by HPLC. CAS No. 891824-47-8. Molecular formula: C34H50F2N4O3. Mole weight: 600.8. | |
| VCH-916 | VCH-916 is a novel allosteric inhibitor of HCV NS5B polymerase. The RNA-dependent RNA polymerase (NS5B) of HCV is one of the attractive validated targets for development of new drugs to block HCV infection. VCH-916 is currently being evaluated for safety/tolerability, pharmacokinetics and anti-viral efficacy in chronically infected HCV patient. Synonyms: VCH916; VCH 916. Grades: >98%. CAS No. 1200133-34-1. Molecular formula: C26H36KNO4S. Mole weight: 497.73. | |
| VDM 11 | VDM 11 is a potent and selective inhibitor of the anandamide membrane transporter (AMT) (IC50 = 4-11 μM), blocking cellular reuptake of anandamide and leads to inactivation of the endocannabinoid signal. VDM 11 also displays negligible agonist activity at the hVR1 receptor and weak action at CB1 and CB2 receptors. Synonyms: VDM 11; VDM11; VDM-11; (5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-methylphenyl)-5,8,11,14-eicosatetraenamide; N-(4-Hydroxy-2-methylphenyl)arachidonylamide. Grades: ≥98% by HPLC. CAS No. 313998-81-1. Molecular formula: C27H39NO2. Mole weight: 409.61. | |
| VE-821 | VE-821 is the first highly selective and potent ATR inhibitor. VE-821 inhibited radiation- and gemcitabine-induced phosphorylation of Chk1, confirming inhibition of ATR signaling. Consistently, VE-821 significantly enhanced the sensitivity of PSN-1, MiaPaCa-2 and primary PancM pancreatic cancer cells to radiation and gemcitabine under both normoxic and hypoxic conditions. Synonyms: VE821; VE-821; VE 821. Grades: 0.98. CAS No. 1232410-49-9. Molecular formula: C18H16N4O3S. Mole weight: 368.41. | |
| Vebreltinib | Vebreltinib is a highly selective c-MET kinase inhibitor with blood-brain barrier permeability and can inhibit non-small cell lung cancer. Synonyms: Bozitinib; PLB-1001. Grades: >98%. CAS No. 1440964-89-5. Molecular formula: C20H15F3N8. Mole weight: 424.4. | |
| Vecuronium Bromide | Vecuronium bromide (Norcuron) is a muscle relaxant in the category of non-depolarizing blocking agents. Vecuronium bromide is indicated as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Although vecuronium bromide is often thought of as a muscle relaxant, it may be more accurate to classify it as a paralyzing agent. Synonyms: NC 45; NC-45; NC45; ORG NC 45; ORG NC45; ORG-NC 45; ORG-NC-45; ORG-NC45; ORGNC 45; ORGNC45; Vecuronium bromide. Brand name Norcuron. Grades: >98%. CAS No. 50700-72-6. Molecular formula: C34H57N2O4.Br. Mole weight: 637.73. | |
| Vedaprofen | Vedaprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used in veterinary medicine. Uses: Anti-inflammatory agents. Synonyms: 2-(4-Cyclohexylnaphthalen-1-yl)-propionic acid. CAS No. 71109-09-6. Molecular formula: C19H22O2. Mole weight: 282.383. | |
| Vedolizumab | Vedolizumab is a monoclonal antibody developed by Millennium Pharmaceuticals for the treatment of ulcerative colitis and Crohn's disease under the trade name Entyvio. Vedolizumab binds to integrin α4β7 (LPAM-1) and blocks α4β7, displaying anti-inflammatory activity. Uses: The treatment of ulcerative colitis and crohn's disease. Synonyms: Entyvio. CAS No. 943609-66-3. Molecular formula: C6528H10072N1732O2042S42. Mole weight: 146836.67. | |
| Vedroprevir | Vedroprevir is a selective hepatitis C virus (HCV) NS3 protease inhibitor. It is a pharmaceutical drug that is used in the treatment of hepatitis C virus in patients with HCV genotype 1(GT1) infection. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion. It retained wild-type activity against multiple classes of NS5B and NS5A inhibitor resistance mutations. It showed good oral bioavailability in all three species tested. It was developed by Gilead Sciences and was terminated in clinic phase 2 trials. Uses: Vedroprevir is a pharmaceutical drug that is used in the treatment of hepatitis c virus in patients with hcv genotype 1(gt1) infection. Synonyms: GS9451; GS-9451; GS 9451; Vedroprevir; (1R,2R)-N-[[(1alpha,3beta,5alpha)-Bicyclo[3.1.0]hex-3-yloxy]carbonyl]-3-methyl-L-valyl-(4R)-4-[[8-chloro-2-[2-[(1-methylethyl)amino]-4-thiazolyl]-7-[2-(4-morpholinyl)ethoxy]-4-quinolinyl]oxy]-L-prolyl-1-amino-2-ethyl-cyclopropanecarboxylic acid;GS9451;GS-9451;(1R,2R)-1-((2S,4R)-1-((2S)-2-(((((1R,5S)-bicyclo[3.1.0]hexan-3-yl)oxy)carbonyl)amino)-3,3-dimethylbutanoyl)-4-((8-chloro-2-(2-(isopropylamino)thiazol-4-yl)-7-(2-morpholinoethoxy)quinolin-4-yl)oxy)pyrrolidine-2-carboxamido)-2-ethylcyclopropane-1-carboxylic acid. Grades: >98%. CAS No. 1098189-15-1. Molecular formula: C45H60ClN7O9S. Mole weight: 910.52. | |
| VEGFR2 Kinase Inhibitor II | VEGFR2 kinase inhibitor II is a reversible and cell-permeable inhibitor of VEGFR2's kinase activity with IC50 value of 70 nM. It also less potently inhibits the platelet-derived growth factor receptor β (PDGFRβ) with IC50 value of 920 nM, and other related receptor as well as non-receptor tyrosine kinases. Synonyms: (Z)-5-Bromo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one. Grades: ≥95%. CAS No. 288144-20-7. Molecular formula: C17H15BrN2O. Mole weight: 343.2. | |
| VEGFR Tyrosine Kinase Inhibitor II | VEGFR tyrosine kinase inhibitor II is a pyridinyl-anthranilamide compound that potently inhibits the kinase activities of VEGFR2 (KDR), VEGFR1 (FLT1), and c-Kit (IC50 = 20, 180, and 240 nM, respectively). It is potential for cancer treatment for its inhibitory effect of tumor induced angiogenesis. Synonyms: N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide. Grades: ≥98%. CAS No. 269390-69-4. Molecular formula: C19H16ClN3O. Mole weight: 337.8. | |
| Velneperit | Velneperit is a once-daily, oral, centrally acting, small molecule neuropeptide Y (NPY) Y5 receptor antagonist. Uses: An optimized synthetic neuropeptide y (npy) y5 receptor antagonist used in the oral treatment of obesity. Synonyms: S-2367; S 2367; S2367; VelneperitN-[5-(Trifluoromethyl)pyridin-2-yl]-trans-4-(tert-butylsulfonylamino)cyclohexane-1-carboxamide. Grades: ≥98%. CAS No. 342577-38-2. Molecular formula: C17H24F3N3O3S. Mole weight: 407.45. | |
| Velusetrag | Velusetrag is a selective, 5-HT4receptor agonist. Phase II clinical trials for the treatment of gastroparesis are on-going. Clnical trials for Alzheimer's disease and Constipation were discontinued. Uses: Gastroparesis. Synonyms: UNII-J4VNV64ARB; TD-5108; TD5108; TD 5108; J4VNV64ARB; GTPL8425;N-[(1R,5S)-8-[(2R)-2-hydroxy-3-[methyl(methylsulfonyl)amino]propyl]-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1-propan-2-ylquinoline-3-carboxamide. Grades: 98%. CAS No. 866933-46-2. Molecular formula: C25H36N4O5S. Mole weight: 504.65. | |
| Vemurafenib-Analog | BRAF inhibitor is a potent BRAF inhibitor. Synonyms: 2-Propanesulfonamide, N-[2,4-difluoro-3-[[5-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]phenyl]-. Grades: >98%. CAS No. 918505-61-0. Molecular formula: C22H18F2N4O3S. Mole weight: 456.47. | |
| VER-49009 | VER-49009 a protein 90 (HSP90) inhibitor(IC50= 47 nM). Uses: A heat shock protein 90 (hsp90) inhibitor. Synonyms: VER49009; VER 49009; VER-49009; (5Z)-5-(3-chloro-4-hydroxy-6-oxocyclohexa-2,4-dien-1-ylidene)-N-ethyl-4-(4-methoxyphenyl)-1,2-dihydropyrazole-3-carboxamide;CCT 129397; CCT129397; CCT-1293975-(5-Chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide. Grades: ≥98%. CAS No. 558640-51-0. Molecular formula: C19H18ClN3O4. Mole weight: 387.82. | |
| VER-50589 | VER-50589 is a potent Hsp90 inhibitor with IC50 of 21 nM for Hsp90&beta. Synonyms: NSC 606170; NSC606170; NSC-606170; Ro 24-2027/000; VER-50589; VER 50589; VER50589. Grades: >98%. CAS No. 747413-08-7. Molecular formula: C19H17ClN2O5. Mole weight: 388.80. | |
| Veralipride | Veralipride is a D2 receptor antagonist in the hypothalamic system and has a half-life of approximately 12 hours. Veralipride is highly active on the neurotransmitters, producing both a weak blockade of the central postsynaptic dopaminergic receptors and particularly a strong blockade of the dopamine receptors in the hypothalamic nuclei. Synonyms: Benzamide, 5-(aminosulfonyl)-2,3-dimethoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]-; 5-(Aminosulfonyl)-2,3-dimethoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]benzamide; Benzamide, 5-(aminosulfonyl)-2,3-dimethoxy-N-[[1-(2-propenyl)-2-pyrrolidinyl]methyl]-; (±)-Veralipride; Agreal; LIR 1660; LIR-1660; LIR1660. Grades: ≥95%. CAS No. 66644-81-3. Molecular formula: C17H25N3O5S. Mole weight: 383.46. | |
| Vercirnon | Vercirnon is a highly potent antagonist of CCR9. Synonyms: 4-(2-((4-(tert-butyl)phenyl)sulfonamido)-5-chlorobenzoyl)pyridine 1-oxide; GSK1605786; GSK 1605786; GSK-1605786; CCX282B; CCX 282B; CCX-282b; CCX282-B. CAS No. 698394-73-9. Molecular formula: C22H21ClN2O4S. Mole weight: 444.93. | |
| Verinurad | Verinurad, a URAT1 inhibitor, has been found to have potential activity against gout and hyperuricaemia and is currently under Phase II trail. IC50: 0.05 μM (EC50). Uses: Verinurad is a urat1 inhibitor that has been found to have potential activity against gout and hyperuricaemia and is currently under phase ii trail. Synonyms: RDEA3170; RDEA-3170; RDEA 3170; Verinurad; UNII-12WJ62D047; Verinurad [INN]; SCHEMBL12070797; 12WJ62D047. Grades: 98%. CAS No. 1352792-74-5. Molecular formula: C20H16N2O2S. Mole weight: 348.42. | |
| Verlukast | This active molecular is a R-enantiomer of MK-571 which is a selective LTD4 receptor antagonist. Verlukast showed [3H]leukotriene D4 binding in guinea-pig with IC50 value of 3.1+/-0.5nM, in human lung homogenates with IC50 value of 8.0+/-3.0nM and in dimethyl sulfoxide differentiated U937 cell membrane preparations with IC50 value of 10.7+/-1.6nM. Verlukast was in clinical development for the treatment of respiratory diseases but was discontinued for treatment of Asthma. Uses: The treatment of respiratory diseases. Synonyms: 3-[[(R)-[3-[(1E)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl][[3-(dimethylamino)-3-oxopropyl]thio]methyl]thio]-propanoic Acid; L 668,019; L 668019; L-668,019; MK 0679; MK 679; MK-679; R-(-)-MK 571. Grades: 95%. CAS No. 120443-16-5. Molecular formula: C26H27ClN2O3S2. Mole weight: 515.09. | |
| Verosudil | Verosudil is a selective Rho-kinase inhibitor originated by Aerie Pharmaceuticals. In Jun 2013, Phase-II for Ocular hypertension in USA was discontinued. In Sep 2013, Phase-II for Glaucoma in USA was discontinued. Uses: Glaucoma; ocular hypertension. Synonyms: AR 12286; AR12286; AR-12286; rac-(2R)-2-(dimethylamino)-N-(1-oxo- 1,2-dihydroisoquinolin-6-yl)-2-(thiophen-3-yl)acetamide. Grades: 98%. CAS No. 1414854-42-4. Molecular formula: C17H17N3O2S. Mole weight: 327.41. | |
| Vesnarinone | Vesnarinone, a quinolinone derivative, is a cardiotonic agent. It has pharmacodynamic effects include inhibition of phosphodiesterase III (PDE3) activity, increases in calcium flux and decreases in potassium flux. Its IC50 value is 1 μM and 300 μM for inhibition of HERG channels and PDE. It is a novel cytokine inhibitor, for the treatment of lung fibrosis using a murine model of bleomycin (BLM)-induced pulmonary fibrosis. It is a new and novel inotropic drug that has unique and complex mechanisms of action. It inhibits phosphodiesterase, thereby leading to increased intracellular calcium, and also affects numerous myocardial ion channels, resulting in the prolongation of the open...eby leading to increased intracellular calcium, and also affects numerous myocardial ion channels, resulting in the prolongation of the opening time of sodium channels and the decrease in the delayed outward and inward rectifying potassium current. it improves ventricular performance most in patients with the worst degree of heart failure. Synonyms: RG-0210; RG 0210; RG0210; OPC-8212; OPC 8212; OPC8212; Piteranometozine; Vesnarinone; Arkin; Arkin-Z. OPC 8212;6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone;3,4-Dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2(1h)-quinolinone. Grades: >98%. CAS No. 81840-15-5. Molecular formula: C22H25N3O4. Mole weight: 395.45. | |
| Vialinin A | Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC50 = 1.5, 5.9 and 22.3 μM, respectively), displaying no significant inhibitory effects on UCH-L3, USP2, and USP8 activity. Vialinin A has been shown to reduce the release of TNF-α (IC50 = 0.09 nM) from RBL-2H3 mast cells. Synonyms: 1,1'-(4,4'',5',6'-Tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl) benzeneacetic acid ester; Ganbajunin C. Grades: ≥98% by HPLC. CAS No. 858134-23-3. Molecular formula: C34H26O8. Mole weight: 562.57. | |
| VIBEGRON | This active molecular is a selective Beta 3 Adrenergic Receptor Agonist and was developed by Kyorin Pharmaceutical for the treatment of OAB (Overactive Bladder). Now, Vibegron is in Phase 3 human clinical trials for the treatment of OAB. In Jan 2015, Vibegron was discontinued Phase-I for hypertension (Combination therapy) in USA. In Mar 2016, Vibegron licensed to Kissei Pharmaceutical in Japan. Uses: Overactive bladder. Synonyms: (6S)-N-[4-[[(2S,5R)-5-[(R)-hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-4-oxo-7,8-dihydro-6H-pyrrolo[1,2-a]pyrimidine-6-carboxamide,MK-4618; MK 4618; MK4618; Vibegron. Grades: 98%. CAS No. 1190389-15-1. Molecular formula: C26H28N4O3. Mole weight: 444.54. | |
| Vibunazole | Vibunazole is usually used as an antifungal agent. Uses: Antifungal agent. Synonyms: Bay N 7133; BayN 7133; Bay-N 7133; Vibunazole; α-[(4-Chlorophenoxy)?methyl]?-α-(1,?1-dimethylethyl)?-1H-1,?2,?4-triazole-1-ethanol. Grades: 98%. CAS No. 80456-55-9. Molecular formula: C15H20ClN3O2. Mole weight: 309.79. | |
| Vicriviroc maleate | Vicriviroc maleate is a CCR5 antagonist. Synonyms: 1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-[(3S)-4-[(1R)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methyl-1-piperazinyl]-4-methyl-piperidine (2Z)-2-butenedioate (1:1). Grades: ≥98% (HPLC). CAS No. 599179-03-0. Molecular formula: C32H42F3N5O6. Mole weight: 649.7. | |
| Vinconate | Vinconate, a vinca alkaloid derivative, can stimulate the muscariic acetylcholine receptor. Vinconate prevents ischemic neuronal damage by direct action on the hippo-campal CAI neurons. Synonyms: methyl 3-ethyl-2,3,3a,4-tetrahydro-1H-indolo(3,2,1-de)(1,5)naphthyridine-6-carboxylate; OC 340; OC-340; OM 853; OM-853; OC340; OM853;vinconate; vinconate hydrochloride, (+-)-isomer; vinconate monohydrochloride, (+-)-isomer. CAS No. 70704-03-9. Molecular formula: C18H20N2O2. Mole weight: 296.36. | |
| Vincristine Sulfate | Vincristine is an inhibitor of polymerization of microtubules by binding to tubulin with IC50 of 32 μM. Uses: Anti-cancer. Synonyms: Leurocristine. Grades: >98%. CAS No. 2068-78-2. Molecular formula: C46H58N4O14S. Mole weight: 923.04. | |
| Vinflunine | Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity. Synonyms: Vinflunine; 162652-95-1; Javlor; UNII-5BF646324K; 20',20'-difluoro-3',4'-dihydrovinorelbine. Grades: 0.98. CAS No. 162652-95-1. Molecular formula: C45H54F2N4O8. Mole weight: 816.944. | |
| Vinflunine ditartrate | Vinflunine, a semisynthetic derivative of Vinorelbine, is the first fluorinated microtubule inhibitor belonging to the Vinca alkaloids family endowed with unique antitumor properties. Uses: Semisynthetic vinca alkaloid with microtubule destabilizing and antiangiogenic activity; derivative of vinorelbine. antineoplastic. Synonyms: 4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine Ditartrate; 20',20'-Difluoro-3',4'-dihydrovinorelbine Ditartrate; BMS 710485; F 12158; Javlor. Grades: >98%. CAS No. 194468-36-5. Molecular formula: C53H66F2N4O20. Mole weight: 1117.10. | |
| Vinflunine Tartrate | Vinflunine induces apoptosis in neuroblastoma SK-N-SH cells through a postmitotic G1 arrest and a mitochondrial pathway in a concentration-dependent manner with an IC50 with 50 nM. Grades: >98%. CAS No. 1201898-17-0. Molecular formula: C45H54F2N4O8.xC4H6O6. Mole weight: 967.02. | |
| Vinyl-L-NIO hydrochloride | Vinyl-L-NIO is a potent and selective nNOS inhibitor with preference for NOS1 (nNOS) over NOS2 (iNOS) and NOS3 (eNOS) with Ki values of 100 nM, 60 and 12 μM, respectively. Synonyms: Vinyl-L-NIO HCl; (2S)-2-amino-5-(1-aminobut-3-enylideneamino)pentanoic acid hydrochloride. Grades: ≥95%. CAS No. 728944-69-2. Molecular formula: C9H17N3O2·HCl. Mole weight: 235.7. | |
| VIP (guinea pig) | VIP (guinea pig) is a neuropeptide that plays a role in neurotransmission, smooth muscle relaxation and has trophic and mitogenic actions. CAS No. 96886-24-7. Molecular formula: C147H239N43O42S2. Mole weight: 3346. | |
| Viridiol | Viridiol is a steroid antibiotic metabolized from viridin. Viridiol acts as a PI3K inhibitor. Synonyms: NSC 658706. Grades: ≥95%. CAS No. 23820-80-6. Molecular formula: C20H18O6. Mole weight: 354.4. | |
| Virodhamine trifluoroacetate | Virodhamine is an endogenous cannabinoid receptor mixed agonist/antagonist. It acts as a full agonist at GPR55 and CB2 and partial agonist/antagonist at CB1 (EC50 values of 12, 381 and 2920 nM for GPR55, CB2 and CB1 receptors respectively). Synonyms: O-(2-Aminoethyl)-5Z,8Z,11Z,14Z-eicosatetraenoate trifluoroacetate. Grades: ≥98% by HPLC. CAS No. 1415264-56-0. Molecular formula: C22H37NO2·CF3CO2H. Mole weight: 461.56. | |
| Vitamin D4 | Vitamin D4 is the active analogue of Vitamin D. Uses: Food additives. Synonyms: RACUMIN D; OLEOVITAMIN D3; VITAMIN D; ANTI-RACHITIC VITAMIN; CALCIOL; CHOLECALCIFEROLUM; COLECALCIFEROL; ACTIVATED 7-DEHYDROCHOLESTEROL. Grades: >98%. CAS No. 511-28-4. Molecular formula: C28H46O. Mole weight: 398.66. | |
| Voacamine | Voacamine is an alkaloid originally isolated from Voacanga. It is a cannabinoid receptor 1 (CB1) antagonist with IC50 value of 41 nM. It has been approved as an antimalarial drug in several African countries. It is also under investigation for modulating multidrug-resistance in tumor cells. Synonyms: NSC 82591; Voacanginine. Grades: ≥98%. CAS No. 3371-85-5. Molecular formula: C43H52N4O5. Mole weight: 704.90. | |
| Volasertib | BI 6727 (Volasertib) is a small highly potent Polo-like kinase inhibitor (Plk) with an IC50 of 0.87 nM and EC50 of 11-37 nM on a panel of cancer cell lines, which exhibited significant anti-proliferative in multiple cancer models, including a model of taxane-resistant colorectal cancer. BI 6727 (Volasertib) caused programmed cell death in colon and non-small cell lung cancer cells both in vitro and in vivo. Synonyms: Volasertib; BI-6727; BI6727; BI 6727. Grades: 0.98. CAS No. 755038-65-4. Molecular formula: C34H50N8O3. Mole weight: 618.827. | |
| Vonoprazan | Vonoprazan is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+ ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. It is used to treat acid-related diseases. It can be used for the treatment of gastroduodenal ulcer (including some drug-induced peptic ulcers) and reflux esophagitis, and can be combined with antibiotics for the eradication of Helicobacter pylori. It is a pyrrole derivative with a chemical structure that is completely different from the P-CABs developed to date in vitro. It inhibits basal gastric acid secretion in a dose-dependent manner, and the ID50 value is 1.26 mg/kg in vivo. It shows a potent and longer-lasting inhibitory effect on the histamine-stimulated gastric acid secretion in rats and dogs. It shows significant antisecretory activity through high accumulation and slow clearance from the gastric tissue. It is unaffected by the gastric secretory state. It was developed by Takeda and Otsuda together. It has been listed. Uses: Vonoprazan is used to treat acid-related diseases. it can be used for the treatment of gastroduodenal ulcer (including some drug-induced peptic ulcers) and reflux esophagitis, and can be combined with antibiotics for the eradication of helicobacter pylori. Synonyms: TAK-438 free base;TAK438 free base; TAK 438 free base; Takecab;1-[5-(2-Fluorophenyl)-1-[(pyridin-3-yl)sulfonyl]-1H-pyrrol-3-yl]-N-methylmethanamine;1H-Pyrrole-3-methanamine,5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl). Grades: >98 %. CAS No. 881681-00-1. Molecular formula: C17H16FN3O2S. Mole weight: 345.39. | |
| Vorasidenib | Vorasidenib is a potent and orally available pan-IDH (isocitrate dehydrogenase) mutant form inhibitor. It has the potential for the treatment of various cancers including glioma, acute myeloid leukemia (AML), cholangiocarcinoma and chondrosarcoma. Synonyms: AG-881; 6-(6-chloropyridin-2-yl)-2-N,4-N-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine. CAS No. 1644545-52-7. Molecular formula: C14H13ClF6N6. Mole weight: 414.74. | |
| Voreloxin | Voreloxin(SNS-595; AG 7352) is a small molecule and a naphthyridine analogue with antineoplastic activity; inhibitor of Topo II. Synonyms: SNS 595; SNS-595; SNS595; SPC-595; SPC595; SPC 595; AG-7352; AG 7352; AG7352; Voreloxin; Vosaroxin. Grades: 0.98. CAS No. 175414-77-4. Molecular formula: C18H19N5O4S. Mole weight: 401.44. | |
| Voreloxin Hydrochloride | Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result, inhibition of DNA replication, RNA and protein synthesis occurs, followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis. This agent shows a favorable toxicity profile in several aspects: it does not generate reactive oxygen species, as do anthracyclines, reducing the risk of cardiotoxicity; it is not a P-glycoprotein (P-gp) substrate, and thereby evades the common mechanism for multidrug resistance; and it has limited distribution to normal tissues and a more chemically stable molecular structure. Synonyms: Voreloxin Hydrochloride. Grades: >98%. CAS No. 175519-16-1. Molecular formula: C18H20ClN5O4S. Mole weight: 437.9. | |
| Vornorexant | Vornorexant is a new and powerful dual orexin 1/2 receptor (OX1/2R) antagonist for the treatment of insomnia. Synonyms: (-)-[2-[[3-(5-Fluoropyridin-2-yl)-1H-pyrazol-1-yl]methyl]-1,3-oxazinan-3-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone. Grades: >98%. CAS No. 2265899-49-6. Molecular formula: C23H22FN7O2. Mole weight: 447.5. | |
| Voruciclib | Voruciclib is a flavone and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. Synonyms: Voruciclib; UNII-W66XP666AM; P1446A05, P1446A-05, P1446A 05. CAS No. 1000023-04-0. Molecular formula: C22H19ClF3NO5. Mole weight: 469.83. | |
| Voxtalisib (XL-765) | Cas No. 934493-76-2. | |
| VP-14637 | VP-14637 is a small molecule inhibitor of respiratory syncytial virus (RSV) with EC50 value of 1.4 nM. It suppresses RSV via binding to the viral F protein and inhibiting the RSV fusion (EC50 = 5.4 nM). Synonyms: VP 14637; VP14637; 2-[[2-Hydroxy-5-[(E)-(5-methyltetrazol-1-yl)iminomethyl]phenyl]-(4-hydroxyphenyl)methyl]-4-[(E)-(5-methyltetrazol-1-yl)iminomethyl]phenol. Grades: ≥98%. CAS No. 235106-62-4. Molecular formula: C25H22N10O3. Mole weight: 510.5. | |
| VPS34 inhibitor 1 | VPS34 inhibitor 1 is a potent and selective inhibitor of VPS34 (IC50 = 15 nM). Vps34 is a phosphoinositide 3-kinase (PI3K) class III isoform that has attracted major attention over the recent years because of its role in autophagy. VPS34 inhibitors can be used to investigate autophagy, a degradation process that recycles cellular components. Synonyms: 1-[[4-(cyclopropylmethyl)-5-[2-(pyridin-4-ylamino)pyrimidin-4-yl]pyrimidin-2-yl]amino]-2-methylpropan-2-ol; Compound 19, PIK-III analogue; Compound 19, PIK-III analogue. Grades: 99.27 %. CAS No. 1383716-46-8. Molecular formula: C21H25N7O. Mole weight: 391.47. | |
| Vps34-PIK-III | Vps34-PIK-III is a potent and selective inhibitor of the type 3 phosphatidylinositol 3-kinase (PI3K) vacuolar protein sorting 34 (Vps34) (IC50 = 18 nM). Vps34-PIK-III is selective for Vps34 over related PI3K isoforms, PI4Kβ, and mTOR. Synonyms: 4-(cyclopropylmethyl)-5-[2-(pyridin-4-ylamino)pyrimidin-4-yl]pyrimidin-2-amine; PIK-III; VPS34-IN2; VPS34-IN 2; VPS34-IN-2. CAS No. 1383716-40-2. Molecular formula: C17H17N7. Mole weight: 319.36. | |
| VR23 | VR23 is a potent and selective inhibitor of trypsin-like proteasomes (IC50 = 1 nmol/L), chymotrypsin-like proteasomes (IC50 = 50-100 nmol/L), and caspase-like proteasomes (IC50 = 3 μmol/L). Synonyms: VR23; VR-23; VR 23. Grades: 98%. CAS No. 1624602-30-7. Molecular formula: C19H16ClN5O6S. Mole weight: 477.88. | |
| VS-5584 | VS-5584 is a pan-PI3K/mTOR kinase inhibitor with IC50s of 16 nM, 68 nM, 42 nM, 25 nM, and 37 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively. VS-5584 simultaneously blocks mTORC2 as well as mTORC1. Synonyms: VS5584; VS 5584; VS5584; SB2343; SB2343; SB 2343. CAS No. 1246560-33-7. Molecular formula: C17H22N8O. Mole weight: 354.418. | |
| VTP-37948 | VTP-37948, also called BI 1181181, being clinically developed with Boehringer Ingelheim and Vitae Pharmaceuticals, is an inhibitor targeted to the catalytic site of the enzymes BACE1 and BACE2 designed for treating Alzheimer's disease. Synonyms: BI 1181181; BI-1181181; VTP-37948; BI1181181; VTP37948; VTP 37948. | |
| VU0029251 | VU002925 1is a partial antagonist of metabotropic glutamate receptor 5 (mGluR5) with Ki value of 1.07 μM. Synonyms: 10-methylsulfanyl-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),8,10-tetraen-12-amine. CAS No. 330819-85-7. Molecular formula: C10H11N3S2. Mole weight: 237.3. | |
| VU 0029767 | VU 0029767 is a positive allosteric modulator of M1, a member of the muscarinic acetylcholine family of GPCRs (mAChRs). VU 0029767 enhances the competitive effect of ACh for M1. VU0029767 potentiates ACh-mediated intracellular calcium mobilization, but not phospholipase D activation. Synonyms: VU0029767, VU 0029767, VU-0029767; 2-(4-ethoxyanilino)-N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]acetohydrazide. Grades: 98%. CAS No. 326001-01-8. Molecular formula: C21H21N3O3. Mole weight: 363.41. | |
| VU0071063 | VU0071063 is a potent and selective Kir6.2/SUR1 potassium channel activator. It inhibits glucose-stimulated calcium entry in isolated mouse pancreatic β-cells. Synonyms: 7-[(4-tert-butylphenyl)methyl]-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione. Grades: ≥98%. CAS No. 333415-38-6. Molecular formula: C18H22N4O2. Mole weight: 326.4. | |
| VU0119498 | VU0119498 is an M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan-mAChR M3, M5 positive allosteric modulator (PAM), and a neuroprotective agent. It has anti-diabetic activity. Synonyms: 1-[(4-Bromophenyl)Methyl]Indole-2,3-Dione; N-4-Bromobenzylisatin; 1-(4-Bromobenzyl)-1H-Indole-2,3-Dione. Grades: 98%. CAS No. 79183-37-2. Molecular formula: C15H10BrNO2. Mole weight: 316.15. | |
| VU 0134992 | VU 0134992 is a Kir4.1 potassium channel blocker with IC50 value of 0.97 μM. Synonyms: 2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide. Grades: ≥98% by HPLC. CAS No. 755002-90-5. Molecular formula: C20H31BrN2O2. Mole weight: 411.38. | |
| VU0152100 | VU0152100 is a selective and positive allosteric modulators of M4 receptor. It has shown a potent positive allosteric modulators that increase the response of the M4 receptor to the endogenous agonist ACh in in vitro study. And it has been revealed to enhance receptor activation by increasing the affinity of M4 for acetylcholine. Synonyms: VU0152100, VU-0152100, VU 0152100, VU152100, VU 152100, VU-152100. Grades: >98%. CAS No. 409351-28-6. Molecular formula: C18H19N3O2S. Mole weight: 341.43. | |
Our database is helping our users find suppliers everyday.
