BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Kibdelin C1 | Kibdelin C1 is originally isolated from Kibdelosporangium aridum subsp. largum SKF AAD-609. Kibdelin C1 is resistant to gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as vancomycin. Alternative Names: Ristomycin A aglycone, 5,22,31,55-tetrachloro-7-demethyl-64-O-demethyl-56-O-(2-deoxy-2-((10-methyl-1-oxoundecyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosyl-N15-methyl-. CAS No. 103549-47-9. Molecular formula: C83H88Cl4N8O29. Mole weight: 1803.43. |  |
| Kibdelin C2 | Kibdelin C2 is originally isolated from Kibdelosporangium aridum subsp. largum SKF AAD-609. Kibdelin C2 is resistant to gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as vancomycin. Alternative Names: Ristomycin A aglycone, 5,22,31,55-tetrachloro-7-demethyl-64-O-demethyl-56-O-(2-deoxy-2-((1-oxododecyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosyl-N15-methyl-. CAS No. 105997-85-1. Molecular formula: C83H88Cl4N8O29. Mole weight: 1803.43. | |
| Kibdelin D | Kibdelin D is originally isolated from Kibdelosporangium aridum subsp. largum SKF AAD-609. Kibdelin D is resistant to gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as vancomycin. Alternative Names: Ristomycin A aglycone, 5,22,31,55-tetrachloro-7-demethyl-64-O-demethyl-56-O-(2-deoxy-2-((1-oxo-4-decenyl)amino)-beta-D-glucopyranosyl)-42-O-alpha-D-mannopyranosyl-N15-methyl-. CAS No. 105997-86-2. Molecular formula: C81H82Cl4N8O29. Mole weight: 1773.36. | |
| Kibdelone A | It is a potent antitumour metabolite isolated from kibdelosporangium sp. MST-108465. It is structurally related to lysolipin and albofungin. It's cytotoxic. Alternative Names: (10S,12S,13R)-4-Chloro-10,11,12,13-tetrahydro-10,12,13,15-tetrahydroxy-8-methoxy-2-methyl-3-propyl-2H-[1]benzopyrano[2',3':6,7]naphth[2,1-g]isoquinoline-1,5,14,16-tetrone. Grades: >95% by HPLC. CAS No. 934464-77-4. Molecular formula: C29H24ClNO10. Mole weight: 581.96. | |
| Kibdelone B | It is a minor analogue of a potent antitumour complex isolated from kibdelosporangium sp. MST-108465. It is structurally related to lysolipin and albofungin. Alternative Names: (10R,12R,13S)-rel-(+)-4-Chloro-6,7,10,11,12,13-hexahydro-10,12,13,15-tetrahydroxy-8-methoxy-2-methyl-3-propyl-2H-[1]benzopyrano[2',3':6,7]naphth[2,1-g]isoquinoline-1,5,14,16-tetrone. Grades: >95% by HPLC. CAS No. 934464-78-5. Molecular formula: C29H26ClNO10. Mole weight: 583.97. | |
| Kigamicin A | Kigamicin A is produced by the strain of Amycolatopsis sp. ML-630-mFl. It showed activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 0.025-0.78 μg/mL. Molecular formula: C34H35NO13. Mole weight: 665.64. | |
| Kigamicin B | Kigamicin B is produced by the strain of Amycolatopsis sp. ML-630-mFl. It showed activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 0.025-0.78 μg/mL. Molecular formula: C40H45NO15. Mole weight: 779.78. | |
| Kigamicin C | Selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower under nutrient starved conditions than in normal conditions; active in vivo against a human pancreatic cancer xenograft model; also inhibits the growth of gram positive bacteria including MRSA, but is not active against gram negative bacteria. Alternative Names: (1S,3R,4S,8aR,11aR)-3-[[(2S,5S,6R)-5-[(2,6-dideoxy-3-O-methyl-b-D-arabinohexopyranosyl)oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-1,2,3,4,8a,9,11,11a,13,14-decahydro-1,4,17,18-tetrahydroxy-11a-methyl-oxazolo[3,2-b]xantheno[4',3',2':4,5][1,3]benzodioxino[7,6-g]isoquinoline-16,19-dione. Grades: >98% by HPLC. CAS No. 680571-51-1. Molecular formula: C41H47NO16. Mole weight: 809.81. | |
| Kigamicin D | Kigamicin D is produced by the strain of Amycolatopsis sp. ML-630-mFl. It showed activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 0.025-0.78 μg/mL. It also shows effect against L-1210 LB32T and other genera tumor cells with IC50 of 1 μg/mL. Alternative Names: 1,2,3a,4,6,7,10,11,12,13-Decahydro-11-[[5-[[5-[(tetrahydro-5-hydroxy-4-methoxy-6-methyl-2H-pyran-2-yl)oxy]tetrahydro-4-methoxy-6-methyl-2H-pyran-2-yl]oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-10,13,15,16-tetrahydroxy-3a-methyl-7,8-(methylenedioxy)-17a-aza-3,9-dioxa-17aH-cyclopenta[b]hexaphene-14,17-dione. Molecular formula: C48H59NO19. Mole weight: 953.98. | |
| Kijanimicin | A tetronic acid related to saccharocarcin, chlorothricin, versipelostatin and tetrocarcin; contains an unusual nitroaminoglycoside; a potent antibacterial, antimalarial and antitumour active; inhibits transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). Alternative Names: NSC 329515; Sch 25663. Grades: >99% by HPLC. CAS No. 78798-08-0. Molecular formula: C67H100N2O24. Mole weight: 1317.51. | |
| KIN1148 | KIN1148, a small-molecule IRF3 agonist, associates with and activates recombinant RIG-I protein in cell-free assays. KIN1148 is a novel influenza vaccine adjuvant found to enhance flu vaccine efficacy. Alternative Names: KIN-1148; KIN 1148; KIN1148; N-([1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl)naphthalene-2-carboxamide. Grades: ≥98% (HPLC). CAS No. 1428729-56-9. Molecular formula: C19H11N3OS2. Mole weight: 361.44. | |
| Kinamycin A | Kinamycin A is produced by the strain of Str. murayamaensis. Kinamycin A has antibacterial and mycobacterial effects, but it has weak activity against gram-negative bacteria. Alternative Names: BRN 0505520; 2,3,4-Tri(acetyloxy)-1,2,3,4,6,11-hexahydro-1,7-dihydroxy-3-methyl-6,11-dioxo-5H-benzo(b)carbazole-5-nitrile; 1,2,3-Tris(acetyloxy)-11-diazonio-4,9-dihydroxy-2-methyl-10-oxo-2,3,4,10-tetrahydro-1H-benzo[b]fluoren-5-olate. Grades: >98%. CAS No. 35303-12-9. Molecular formula: C24H20N2O10. Mole weight: 496.42. | |
| Kinamycin B | Kinamycin B is produced by the strain of Str. murayamaensis. Kinamycin B has antibacterial and mycobacterial effects, but it has weak activity against gram-negative bacteria. Alternative Names: BRN 0503790; (1R,2R,3R,4S)-2-acetyloxy-11-diazonio-1,3,4,10-tetrahydroxy-2-methyl-9-oxo-3,4-dihydro-1H-benzo[b]fluoren-5-olate. Grades: >98%. CAS No. 35303-13-0. Molecular formula: C20H16N2O8. Mole weight: 412.35. | |
| KIRA6 | KIRA6 allosterically inhibits IRE1α RNase kinase activity in vivo and promotes cell survival under ER stress. Systemically, KIRA6 preserves pancreatic β cells, increases insulin, and reduces hyperglycemia in Akita diabetic mice. Alternative Names: KIRA6; KIRA-6; KIRA 6; 1-[4-(8-amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea; 1-(4-(8-amino-3-(tert-butyl)imidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea; KIRA analog, 2. CAS No. 1589527-65-0. Molecular formula: C28H25F3N6O. Mole weight: 518.53. | |
| Kirrothricin | Kirrothricin is originally isolated from Str. cinnamomeus Tu89. It has antibacterial action, but no activity to subtilis, Escherichia coli and fungi. Alternative Names: 2H-Pyran-2-acetamide, N-((2E,4E,6S,7S,9S,10E,12E,14E,16E)-8,9-dihydroxy-6-methoxy-5,7,17-trimethyl-18-oxo-18-(1,2,5,6-tetrahydro-4-hydroxy-1-methyl-2-oxo-3-pyridinyl)-2,4-dihydroxy-5,5-dimethyl-6-((1E,3Z)-1,3-pentadienyl)-, (alphaS,2S,4S,6S)-. CAS No. 79190-00-4. Molecular formula: C44H64N2O10. Mole weight: 780.98. | |
| Kistamicin A | Kistamicin A is produced by the strain of Microtetraspora parvasata subsp. kistna. It has antiviral effect, and its ID50 (μg/mL) against influenza virus MDCK cells and herpes simplex virus are respectively 3.6 and 44. It also has anti-gram-positive bacterial effects. Alternative Names: Kistamycin A. CAS No. 155683-50-4. Molecular formula: C61H51ClN8O15. Mole weight: 1171.55. | |
| Kistamicin B | Kistamicin B is produced by the strain of Microtetraspora parvasata subsp. kistna. It has antiviral effect, and its ID50 (μg/mL) against influenza virus MDCK cells and herpes simplex virus are respectively 1.8 and 30. Alternative Names: Kistamycin B. CAS No. 155683-51-5. Molecular formula: C70H60ClN9O16. Mole weight: 1318.73. | |
| Kitamycin A | It is originally isolated from Strptomyces sp. K385. Kitamycin A can inhibit the activity of plant growth. Molecular formula: C23H32N2O8. Mole weight: 464.51. | |
| Kobusin | Kobusin is a lignan isolated from the barks of Zanthoxylum rhetsa that exhibits antiplasmodial and anti-inflammatory properties. Alternative Names: (+)-Demethoxyaschantin; Demethoxyaschantin; Methylpiperitol; (+)-Spinescin; 5-[(3S,3aR,6S,6aR)-6-(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-1,3-benzodioxole. Grades: >98%. CAS No. 36150-23-9. Molecular formula: C21H22O6. Mole weight: 370.401. | |
| Kodaistatin A | Kodaistatin A is originally isolated from Asperrgilus terreus Thom DSM 11237. It inhibits the glucose-6-phosphotransferase T1 (G-6-P-T1) with the IC50 of 80 nmol/L. Molecular formula: C35H34O11. Mole weight: 630.64. | |
| Kodaistatin C | Kodaistatin B is originally isolated from Asperrgilus terreus Thom DSM 11237. It inhibits the glucose-6-phosphotransferase T1 (G-6-P-T1) with the IC50 of 130 nmol/L. Alternative Names: Kodaistatin B. Molecular formula: C35H34O12. Mole weight: 646.64. | |
| Korormicin | It has the effect of resisting Marine gram-negative bacteria, but not against the marine gram-positive bacteria and general bacteria. Alternative Names: (3R,4Z,6E)-N-[(5S)-5-Ethyl-5-methyl-2-oxo-2,5-dihydro-3-furanyl]-3-hydroxy-8-[(2S,3R)-3-octyl-2-oxiranyl]-4,6-octadienamid. Molecular formula: C25H39NO5. Mole weight: 433.58. | |
| Kosinostatin | Kosinostatin is originally isolated from Paecilomyces sp. FO-3184. It showed strong anti-gram-positive bacterial activity (MIC of 0.039 μg/mL) and moderate anti-gram-negative bacterial and yeast activity (MIC of 1.56-12.5 μg/mL). It is also poisonous to the cells of a wide variety of tumor cells with the IC50 of 0.02-0.6 μmol/L. And the IC50 of inhibition of DNA topoisomerase IIα is 3-10 μmol/L. Alternative Names: Isoquinocycline B. Molecular formula: C33H32N2O10. Mole weight: 616.61. | |
| KS-501 | It is produced by the strain of Sporothrix sp. KAC-1989. KS-501 inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 1.8 μmol/L. Alternative Names: KS 501; 3-Heptyl-5-hydroxyphenyl 2-heptyl-6-(hexofuranosyloxy)-4-hydroxybenzoate. CAS No. 120634-86-8. Molecular formula: C33H48O10. Mole weight: 604.73. | |
| KS 502 | It is produced by the strain of Sporothrix sp. KAC-1989. KS 502 inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 4.4 μmol/L. Alternative Names: Benzoic acid, 2-(beta-D-galactofuranosyloxy)-6-heptyl-4-hydroxy-, 4-carboxy-3-heptyl-5-hydroxyphenyl ester. Grades: >98%. CAS No. 120634-85-7. Molecular formula: C34H48O12. Mole weight: 648.74. | |
| KS 504a | It is produced by the strain of Mollisia ventosa KAC-1148. KS 504a inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 122 μmol/L. Alternative Names: KS-504a; KS-504b; BRN 4354490; 1-Oxaspiro(2.4)heptan-5-ol, 2,4,4,6,6-pentachloro-7-(dichloromethylene)-. CAS No. 122022-77-9. Molecular formula: C7H3Cl7O2. Mole weight: 367.27. | |
| KS-504d | It is produced by the strain of Mollisia ventosa KAC-1148. KS-504d inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of >500 μmol/L. Alternative Names: KS 504d; BRN 4322179; (+)-1-(Dichloromethyl)-5-(dichloromethylene)-2,2,4,4-tetrachloro-1,3-cyclopentanediol. CAS No. 122005-23-6. Molecular formula: C7H4Cl8O2. Mole weight: 403.73. | |
| KS-504e | It is produced by the strain of Mollisia ventosa KAC-1148. KS-504e inhibited Ca2+ and calmodulin dependent cyclic-nucleotide phosphodiesterase with an IC50 of 139 μmol/L. Alternative Names: KS 504e; BRN 4321107; (+)-4-Hydroxy-3,3,5,5-tetrachloro-2-(trichloromethyl)-1-cyclopentene-1-carboxaldehyde; 1-Cyclopentene-1-carboxaldehyde, 3,3,5,5-tetrachloro-4-hydroxy-2-(trichloromethyl)-, (+)-. CAS No. 122006-32-0. Molecular formula: C7H3Cl7O2. Mole weight: 367.27. | |
| KS-619-1 | It is produced by the strain of Streptomyces californicus KS-619-1. KS-619-1 inhibited Ca2+ and CAM-PDE in bovine brain and heart with an IC50 of 2.0 and 1.5 μmol/L. Alternative Names: KS 619-1; Benzo(a)naphthacene-2-carboxylic acid, 5,6,8,13-tetrahydro-1,7,9,11-tetrahydroxy-8,13-dioxo-3-(2-oxopropyl)-. CAS No. 103370-21-4. Molecular formula: C26H18O9. Mole weight: 474.41. | |
| KT5720 | KT 5720, an anti-bacterial agent synthesized by the fungus Nocardiopsis sp, specifically blocks PKA signaling through competitive inhibition of ATP with a Ki value of 60 nM. Uses: Anti-bacterial agents. Alternative Names: 2,3,9,10,11,12-hexahydro-10S-hydroxy-9-methyl-1-oxo-9R,12S-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, hexyl ester; KT 5720; KT5720; KT-5720. Grades: 98%. CAS No. 108068-98-0. Molecular formula: C32H31N3O5. Mole weight: 537.60. | |
| KT5823 | KT 5823 is a cell-permeable, selective inhibitor of cGMP-dependent protein kinase (PKG) (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). KT 5823 is often used in intact cells to assess the role of PKG in signaling, although there are cases where it poorly inhibits PKG in cells. Uses: Kt5823 induces apoptotic fragmentation of dna. Alternative Names: KT 5823; KT-5823; KT5823; 2,3,9,10,11,12-hexahydro-10R-methoxy-2,9-dimethyl-1-oxo-9S,12R-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester. Grades: ≥98%. CAS No. 126643-37-6. Molecular formula: C29H25N3O5. Mole weight: 495.52. | |
| Kumbicin C | Kumbicin C is a bis-indolyl benzenoid fungal metabolite produced by A. kumbius FRR6049. Kumbicin C was found to inhibit the growth of mouse myeloma cells (IC50 = 0.74 μg/mL) and the Gram-positive bacterium Bacillus subtilis (MIC = 1.6 μg/mL). Alternative Names: 5,8-di-1H-indol-3-yl-7-methoxy-2,2-dimethyl-2H-1-benzopyran-6-ol. Grades: ≥95%. CAS No. 1878151-58-6. Molecular formula: C28H24N2O3. Mole weight: 436.50. | |
| Kurasoin A | It is produced by the strain of Paecilomyces sp. FO-3184, Kurasoin A has the effect of inhibiting the protein fannicyl transferase. Alternative Names: (+)-Kurasoin A; (S)-3-Hydroxy-4-(4-hydroxyphenyl)-1-phenyl-2-butanone. CAS No. 182232-62-8. Molecular formula: C16H16O3. Mole weight: 256.30. | |
| Kurasoin B | It is produced by the strain of Paecilomyces sp. FO-3184, Kurasoin B has the effect of inhibiting the protein fannicyl transferase. Alternative Names: (+)-Kurasoin B. Molecular formula: C18H17NO2. Mole weight: 279.33. | |
| Kushenol I | Kushenol I is a compound of the flavonoid class found in the Sophora flavescens Ait. Kushenol I is a GABAA receptor modulator and a Sodium-dependent glucose cotransporter 2(SGLT2) inhibitor. Alternative Names: NSC 668937. Grades: >98%. CAS No. 99119-69-4. Molecular formula: C26H30O7. Mole weight: 454.5. | |
| KY-226 | KY-226 is a protein tyrosine phosphatase 1B (PTP1B) inhibitor that protects neurons from cerebral ischemic injury. It significantly reduced plasma glucose, triglyceride, and A1c levels without weight gain in db/db mice. Uses: Enzyme inhibitors. Alternative Names: 4-(biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide; BCP32729; EX-A3829. CAS No. 1621673-53-7. Molecular formula: C27H31NO3S2. Mole weight: 481.7. | |
| Kynapcin-12 | It is produced by the strain of Polyozellus multiplex. It has the activity of inhibiting proline endopeptidase (PEP, EC 3.4.21.26) with IC50 of 1.25 μg/mL. Alternative Names: kynapcin 12. Molecular formula: C22H18O8. Mole weight: 410.37. | |
| Kynapcin-28 | It is produced by the strain of Polyozellus multiplex. It can non-competitively inhibit the activity of PEP with IC50 of 0.98 μmol/L. It has little inhibitory effect on other serine proteases. Alternative Names: kynapcin 28. Molecular formula: C19H12O10. Mole weight: 400.29. | |
| L-156602 | L-156602 is extracted from Streptomyces sp. MA6348, and it is the antagonist of Anaphylatoxin C5a. It is also a cyclic depsipeptide antibiotic that is active against Gram-positive bacteria. Alternative Names: Antibiotic L 156602; Antibiotic PD-124966; GNF-Pf-75; L 156602; PD-124966; (3S)-3-hydroxy-N-[(2S)-2-hydroxy-1-oxo-2-[(2R,5R,6R)-tetrahydro-2-hydroxy-6-methyl-5-[(2S)-2-methylbutyl]-2H-pyran-2-yl]propyl]-L-leucyl-(3R)-hexahydro-3-pyridazinecarbonyl-N-hydroxy-L-alanylglycyl-(3S)-hexahydro-3-pyridazinecarbonyl-N-hydroxy-D-alanine, (6→13)-lactone. Grades: >95% by HPLC. CAS No. 125228-51-5. Molecular formula: C38H64N8O13. Mole weight: 840.96. | |
| L-2,5-Dihydrophenylalanine | It is produced by the strain of Streptomyces sp. L-2,5-Dihydrophenylalanine can cause apoptosis of HL-60 in human myeloblastoid leukemia cells. Alternative Names: 2,5-Dihydrophenylalanine; 2,5-dihydrophenyl-L-alanine; L-3-(2,5-Cyclohexadienyl)alanine. CAS No. 16055-12-2. Molecular formula: C9H13NO2. Mole weight: 167.20. | |
| L-2-Hydroxybutyric acid | L-2-Hydroxybutyric acid (CAS# 3347-90-8) is used in method for preparing Cationic Electrodeposition coating compounds. Alternative Names: S-2-hydroxybutyric acid. CAS No. 3347-90-8. Molecular formula: C4H8O3. Mole weight: 104.1. | |
| L-671776 | L-671776 is a myo-inositol monophosphatase (IMPase) inhibitor produced by Memnoniella echinata. Alternative Names: L 671776; 4,6'-dihydroxy-6-(hydroxymethyl)-2',5',5',8a'-tetramethyl-3',4',4a',5',6',7',8',8a'-octahydro-2'H,3H-spiro[benzofuran-2,1'-naphthalene]-5-carbaldehyde; L-671,776; Spiro(benzofuran-2(3H),1'(2'H)-naphthalene)-5-carboxaldehyde, 3',4',4'a,5',6',7',8',8'a-octahydro-4,6'-dihydroxy-6-(hydroxymethyl)-2',5',5',8'a-tetramethyl-. Grades: >98%. CAS No. 134313-74-9. Molecular formula: C23H32O5. Mole weight: 388.50. | |
| L-681176 | L-681176 is originally isolated from Streptomyces sp. MA 5143a. It has the activity of inhibiting angiotensin transferase. Alternative Names: L-681,176. CAS No. 91386-17-3. Molecular formula: C12H23N5O7. Mole weight: 349.34. | |
| L-681217 | A glycolipid-type antibiotic related to the efrotomycin class; isolated from a streptomyces sp.; shows broad spectrum antibiotic activity against gram positive and gram negative bacteria. Alternative Names: L 681217; Antibiotic L-681217; 2,4,6-Heptatrienoic acid, 7-(tetrahydro-3-hydroxy-5-(2-methoxy-1,3-dimethyl-7-((1-oxo-2-(tetrahydro-2,4,5-trihydroxy-5-methyl-6-(1,3-pentadienyl)-2H-pyran-2-yl)butyl)amino)-3,5-heptadienyl)-2-furanyl)-. Grades: >95% by HPLC. CAS No. 93522-10-2. Molecular formula: C36H53NO10. Mole weight: 659.80. | |
| L 687781 | L 687781, an inhibitor of β-1,3-D-glucan synthase, is originally isolated from Dictyochaeta simplex. It also has anti-Candida fungal activity and has some effects on Pneumocystis carinii. Alternative Names: Hexopyranose, 1,6'-anhydro-1-C-(2,4-dihydroxy-6-(hydroxymethyl)phenyl)-4-O-(6-O-(8-hydroxy-1-oxo-2,4-decadienyl)hexopyranosyl)-, 3-(7-hydroxy-8,14-dimethyl-1-oxo-2,4,6,8,10-hexadecapentaenoate). CAS No. 130304-58-4. Molecular formula: C47H66O17. Mole weight: 903.01. | |
| L-696474 | L-696474 is extracted from Hypoxylon fragiforme MF5511. It can competitively inhibit the action of HIV-1 protease with an IC50 of 3 μmol/L. Alternative Names: L-696,474; 18-dehydroxycytochalasin H. Grades: >98% by HPLC. CAS No. 141994-72-1. Molecular formula: C30H39NO4. Mole weight: 477.63. | |
| L-783277 | L-783277 is originally isolated from Phoma sp. It inhibits MEK2 with an IC50 of 4 nmol/L. Alternative Names: (3S,5Z,8S,9S)-3,4,9,10,11,12-Hexahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione; LL-783277. Grades: ≥95%. CAS No. 791807-02-8. Molecular formula: C19H24O7. Mole weight: 364.39. | |
| LA-1 | LA-1 is an aliphatic unsaturated ketonic acid produced by Streptomyces kitasatoensis NU-4-4-2. It has anti-gram-positive bacteria activity. CAS No. 61947-93-1. Molecular formula: C10H10O3. Mole weight: 178.18. | |
| Labetalol-1-carboxylic Acid Methyl Ester | An impurity of Labetalol, a beta blocker used to treat high blood pressure. Alternative Names: Methyl labetalol acid; Labetalol Impurity B. CAS No. 802620-01-5. Molecular formula: C20H25NO4. Mole weight: 343.4. | |
| Labilomycin | It is produced by the strain of Str. albospoeus var. labilomyceticus A955-y3. It's a sugar antibiotic. It has anti-gram-positive bacteria, mycobacterium activity. It had cytotoxic effect on HeLa cells and Yoshida sarcoma cells. Each rat (Transplantation of airy ascites carcinoma in mice) is given Labilomycin of 250 μg/d, it can inhibit tumor and prolong life. It has a protective effect on mice infected with S. aureus. Serum does not affect its antibacterial activity. Alternative Names: Pulvomycin; Oxacyclodocosa-4,7,9,11,15,17,19-heptaene-2,13-dione, 22-[(1S,2S,3S,5E,7E,9E,11S,12S)-12-[(6-deoxy-2,4-di-O-methyl-β-D-galactopyranosyl)oxy]-2,11-dihydroxy-1,3-dimethyl-4-oxo-5,7,9-tridecatrien-1-yl]-6,14-dihydroxy-5,8,12-trimethyl-, (4E,6R,7E,9E,11E,14S,15E,17E,19E,22S)-; (4E,6R,7E,9E,11E,14S,15E,17E,19E,22S)-22-[(1S,2S,3S,5E,7E,9E,11S,12S)-12-[(6-Deoxy-2,4-di-O-methyl-β-D-galactopyranosyl)oxy]-2,11-dihydroxy-1,3-dimethyl-4-oxo-5,7,9-tridecatrien-1-yl]-6,14-dihydroxy-5,8,12-trimethyloxacyclodocosa-4,7,9,11,15,17,19-heptaene-2,13-dione; (-)-Pulvomycin; Antibiotic 1063Z. CAS No. 11006-66-9. Molecular formula: C47H66O13. Mole weight: 839.02. | |
| Laccaridione A | It is produced by the strain of Laccaria amethystea. It can inhibit the activity of antiserine protease. It inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC50 (μg/mL) of 14.7, 2.5, 18.8, 7.2 and 18.2, respectively. Alternative Names: 10-hydroxy-1,7-dimethoxy-3-[(2E)-4-methylhex-2-en-2-yl]-1H-benzo[g]isochromene-8,9-dione; 1H-Naphtho(2,3-C)pyran-8,9-dione, 3-((1E)-1,3-dimethyl-1-penten-1-yl)-10-hydroxy-1,7-dimethoxy-. CAS No. 320369-80-0. Molecular formula: C22H24O6. Mole weight: 384.42. | |
| Laccaridione B | It is produced by the strain of Laccaria amethystea. It can inhibit the activity of antiserine protease. It inhibits trypsin, papain, thermophilic protease, collagenase and zinc protease with IC50 (μg/mL) of 10.9, 5.1, 8.4, 5.7 and 3.0, respectively. It also has a strong anti-proliferative activity against L-929, K-562 and HeLa cells with IC50 (μg/mL) of 2.4, 1.8 and 13.9, respectively. Alternative Names: 1-ethoxy-10-hydroxy-7-methoxy-3-[(2E)-4-methylhex-2-en-2-yl]-1H-benzo[g]isochromene-8,9-dione; 1H-Naphtho[2,3-c]pyran-8,9-dione, 3-[(1E)-1,3-dimethyl-1-pentenyl]-1-ethoxy-10-hydroxy-7-methoxy-. CAS No. 320369-81-1. Molecular formula: C23H26O6. Mole weight: 398.45. | |
| Lachnone A | It is a chromone isolated from the filamentous fungus, lachnum sp. It possesses weak activity against bacteria but has not been extensively investigated. Alternative Names: Lanchnone A; 3,5-Dihydroxy-2,7-dimethyl-4H-1-benzopyran-4-one. Grades: >95% by HPLC. CAS No. 903892-99-9. Molecular formula: C11H10O4. Mole weight: 206.19. | |
| Lachnumol A | It is produced by the strain of Lachnum papyraceum. It has weaker activity against bacteria, yeast and filamentous fungi. It has cytotoxic activity against L1210, HeLa, KB and other cell lines. Alternative Names: La; 1-chloro-6-[(Z)-1-chloroprop-1-enyl]-4-methoxy-7-oxabicyclo[4.1.0]hept-3-ene-2,5-diol; 7-Oxabicyclo(4.1.0)hept-3-ene-2,5-diol, 6-chloro-1-(1-chloro-1-propenyl)-3-methoxy-. CAS No. 150671-03-7. Molecular formula: C10H12Cl2O4. Mole weight: 267.11. | |
| Lachnumon | It is produced by the strain of Lachnum papyraceum. It has weaker activity against bacteria, yeast and filamentous fungi. It has cytotoxic activity against L1210, HeLa, KB and other cell lines. Alternative Names: Ln; 7-Oxabicyclo(4.1.0)hept-3-en-2-one, 1-chloro-6-(1-chloro-1-propenyl)-5-hydroxy-4-methoxy-; 6-chloro-1-[(Z)-1-chloroprop-1-enyl]-2-hydroxy-3-methoxy-7-oxabicyclo[4.1.0]hept-3-en-5-one. CAS No. 150671-02-6. Molecular formula: C10H10Cl2O4. Mole weight: 265.09. | |
| Lacidipine | Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. Lacidipine (Lacipil, Motens) works by relaxing and opening up the blood vessels. Alternative Names: GX-1048,GR-43659X,SN-305; GX 1048,GR 43659X,SN 305; GX1048,GR43659X,SN305. Grades: >98%. CAS No. 103890-78-4. Molecular formula: C26H33NO6. Mole weight: 455.54. | |
| Lactaroviolin | It is produced by the strain of Lactarius deliciosus. It is an aromatic derivative antibiotic. It can inhibit the growth of Mycobacterium tuberculosis, but the effect is not strong. Alternative Names: Lactarioviolin; 1-Azulenecarboxaldehyde, 4-methyl-7-(1-methylethenyl)-; 1-Formyl-7-isopropenyl-4-methylazulene; 1,3,5,7,9,11-Guaiahexaen-15-al; 7-Isopropenyl-4-methyl-1-Azulenecarboxaldehyde. CAS No. 85-33-6. Molecular formula: C15H14O. Mole weight: 210.27. | |
| Lactonamycin | It is produced by the strain of Streptomyces rishiriensis MJ 773-88K4. It had strong activity against gram-positive bacteria including staphylococcus, streptococcus, enterococcus, MRSA (MIC is 0.39-0.78 μg/mL) and VRE (MIC is 0.39-0.78 μg/mL). It also has inhibitory effect on L-1210, P388, S180, FS-3, Ehrlich, B16-BL5 and other tumor cell lines (IC50 is 0.06-3.3 μg/mL). Alternative Names: (3aS,5aS,14aR)-9,13-dihydroxy-5a-{[(2S,5S,6S)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-3a-methoxy-11-methyl-3,3a,11,12-tetrahydro-2H,5H-furo[2'',3'':4',5']furo[3',4':6,7]naphtho[2,3-e]isoindole-2,6,10,14(5aH)-tetrone; (+)-Lactonamycin. CAS No. 182234-02-2. Molecular formula: C28H27NO12. Mole weight: 569.51. | |
| Lactonamycin Z | It is produced by the strain of Streptomyces sp. AK 623. It's an antitumor antibiotic. It has weak anti-gram-positive bacterial activity. It can inhibit human tumor cells HMO2, MCF7 and Hep G2 with GI50 (μg/mL) of 1.9, 0.85 and 5.11, respectively. Molecular formula: C28H27NO13. Mole weight: 585.51. | |
| Lactoquinomycin A | It is produced by the strain of Str. tanashiensis IM 8442T. It's a quinone antibiotic. It has the activity of anti-gram-positive bacteria and some gram-negative bacteria, but the effect of anti-gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin A has stronger antibacterial activity than Lactoquinomycin B. It inhibits a variety of cell lines including lymphoma L5178Y progenitor, adriamycin resistant, bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.02, 0.006, 0.008, 0.033, 0.013 and 0.03, respectively. Alternative Names: Lactoquinomycin A; Medermycin; [3aS,(-)]-3,3aβ,5,11bβ-Tetrahydro-7-hydroxy-5β-methyl-8-[3-(dimethylamino)-2,3,6-trideoxy-L-arabino-hexopyranosyl]-2H-furo[3,2-b]naphtho[2,3-d]pyran-2,6,11-trione; Antibiotic K 73A; 2H-Furo[3,2-b]naphtho[2,3-d]pyran-2,6,11-trione,3,3a,5,11b-tetrahydro-7-hydroxy-5-methyl-8-[2,3,6-trideoxy-3-(dimethylamino)-beta-D-arabino-hexopyranosyl]-, (3aR,5R,11bR)-. Grades: 95%. CAS No. 60227-09-0. Molecular formula: C24H27NO8. Mole weight: 457.48. | |
| Lactoquinomycin B | It is produced by the strain of Str. tanashiensis IM 8442T. It's a quinone antibiotic. It has the activity of anti-gram-positive bacteria and some gram-negative bacteria, but the effect of anti-gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin A has stronger antibacterial activity than Lactoquinomycin B. It inhibits a variety of cell lines including lymphoma L5178Y progenitor, adriamycin resistant, bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.43, 0.21, 0.19, 0.16, 0.2 and 0.12, respectively. Alternative Names: 3a,11b-Dihydro-7-hydroxy-5-methyl-8-[2,3,6-trideoxy-3-(dimethylamino)-β-D-arabino-hexopyranosyl]-5a,11a-epoxy-5H-furo[3,2-b]naphtho[2,3-d]pyran-2,6,11(3H)-trione; 5a,11a-Epoxy-5H-furo[3,2-b]naphtho[2,3-d]pyran-2,6,11(3H)-trione, 3a,11b-dihydro-7-hydroxy-5-methyl-8-[2,3,6-trideoxy-3-(dimethylamino)-b-D-arabino-hexopyranosyl]-. CAS No. 101342-94-3. Molecular formula: C24H27NO9. Mole weight: 473.48. | |
| Lactosillan | It is produced by the strain of Alcaligenes latus G66A. Latosillan is a cell differentiation inducer that can differentiate myeloid leukemia cells into macrophages. Alternative Names: Latosillan. CAS No. 83712-86-1. Molecular formula: C32H55NO23. Mole weight: 821.77. | |
| Lagunamycin | It is produced by the strain of Str. sp. AA0310. It can inhibit 5-fat oxygenase with IC50 of 6.08 μmol/L, but dose not inhibit lipid peroxidation. It has the activity of anti-gram-positive bacteria, not anti-gram-negative bacteria. Alternative Names: (E)-(-)-6-Diazo-3-methyl-4-(1,3,5-trimethyl-1-hexenyl)-2,5,7,8(1H,6H)-quinolinetetrone; 6-diazonio-4-[(E)-4,6-dimethylhept-2-en-2-yl]-3-methyl-2,7,8-trioxo-1H-quinolin-5-olate. Grades: 95%. CAS No. 150693-65-5. Molecular formula: C19H21N3O4. Mole weight: 355.39. | |
| Laidlomycin | It is produced by the strain of Str. sp. S-822. It is an oxygen-containing heterocyclic antibiotic. It has anti-gram-positive bacterial and mycoplasma activity. Alternative Names: Laidlomicina; Laidlomycine; Laidlomycinum; 16-Deethyl-3-O-demethyl-16-methyl-3-O-(1-oxopropyl)monensin. Grades: 95%. CAS No. 56283-74-0. Molecular formula: C37H62O12. Mole weight: 698.89. | |
| L-Alaninamide | L-Alaninamide. Alternative Names: H-Ala-NH2. CAS No. 7324-5-2. Molecular formula: C3H8N2O. Mole weight: 88.1. | |
| Lambertellin | It is produced by the strain of Lambertella hicoriae, Lam. cornimaris. It's a quinone antibiotic. It has anti-gram-positive bacterial and fungal activity. Alternative Names: 2H-Naphtho(2,3-b)pyran-2,5,10-trione, 9-hydroxy-3-methyl-; 9-hydroxy-3-methyl-2h-naphtho-(2,3-b)pyran-2,5,10-trione. CAS No. 28980-51-0. Molecular formula: C14H8O5. Mole weight: 256.21. | |
| Lanabecestat | Lanabecestat, also referred to AZD3293, is an orally active and highly permeable potent inhibitor of human β-secretase 1 in clinical development for the treatment of Alzheimer disease with a Ki of 0.4 nM. Alternative Names: (1r,4r)-4-methoxy-5''-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine; 4-methoxy-5'-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro(cyclohexane-1,2'-inden-1',2'-imidazol)-4'-amine; AZD3293; AZD 3293; AZD-3293. CAS No. 1383982-64-6. Molecular formula: C26H28N4O. Mole weight: 412.53. | |
| Lankamycin | It is produced by the strain of Str. violaceoniger NRRL 2834. It's a macrolide antibiotic. It has weak anti-gram-positive bacterial activity. It has cross-resistance with Picromycin and synergistic effect with Lankacidin. Alternative Names: Lankavamycin; Kujimycin B; Antibiotic A-20338-N2; [3R-[3R*,4S*,5R*,6S*,7S*,9S*,11R*,12S*,13S*,14R*(1S*,2S*)]]-4-[(4-O-Acetyl-2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-xylo-hexopyranosyl)oxy]-12-(acetyloxy)-6-[(4,6-dideoxy-3-O-methyl-b-D-xylo-hexopyranosyl)oxy]-9-hydroxy-14-(2-hydroxy-1-methylpropyl)-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione. Grades: 98%. CAS No. 30042-37-6. Molecular formula: C42H72O16. Mole weight: 833.02. | |
| Lanopylin A1 | It is produced by the strain of Streptomyces sp. K99-5041. It can inhibit recombinant human lanosterol synthase (EC 5.4.99.7) with IC50 of 15 μmol/L. Alternative Names: 2-Methyl-3-[(E)-15-methylhexadecane-1-ylidene]-4,5-dihydro-3H-pyrrole. Molecular formula: C22H41N. Mole weight: 319.57. | |
| Lanopylin A2 | It is produced by the strain of Streptomyces sp. K99-5041. It can inhibit recombinant human lanosterol synthase (EC 5.4.99.7) with IC50 of 18 μmol/L. Molecular formula: C24H43N. Mole weight: 345.60. | |
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