BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Methyl (methyl-4-deoxy-alpha-L-threo-hex-4-enopyranosid)uronate | Methyl (methyl-4-deoxy-alpha-L-threo-hex-4-enopyranosid)uronate stands as a quintessential biomedical compound with potential antitumor attributes. CAS No. 24909-33-9. Molecular formula: C8H12O6. Mole weight: 204.18. |  |
| Methyl (methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-thio-D-glycero-D-galacto-2-nonulopyranosid)onate | Methyl (methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-thio-D-glycero-D-galacto-2-nonulopyranosid)onate is a paramount chemical compound, used as a pivotal building block in synthesizing pharmaceutical compounds designed to modulate specific enzymatic cascades or receptor systems. CAS No. 144240-36-8. Molecular formula: C23H31NO12S. Mole weight: 545.56. | |
| Methyl-N-acetylneuraminate | Methyl-N-acetylneuraminate is a prominent biomedical product, serving as a precursor for the synthesis of drugs based on sialic acid. Its profound sialylation attributes lend themselves predominantly to the efficacious research of multifarious maladies, ranging from cancer to viral infections and autoimmune disorders. Synonyms: N-Acetylneuraminic acid methyl ester; Methyl N-acetylneuraminate; Neuraminic acid, N-acetyl-, methyl ester; methyl (4S,5R,6R)-5-acetamido-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate; methyl 5-acetamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosonate; N-ACETYLNEURAMINICACIDMETHYLESTER; Lactaminic acid, methyl ester; Methyl N-acetylneuraminate; N-Acetyl-D-neuraminic acid methyl ester or Sialic acid methyl ester;(4S,5R,6R)-methyl 5-acetamido-2,4-dihydroxy-6-((1R,2R)-1,2,3-trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylate. Molecular formula: C12H21NO9. Mole weight: 323.3. | |
| Methylphenyl 2,3,4-tri-O-benzyl-b-L-thiorhamnopyranose | | |
| Methyl (phenyl 2,3-di-O-benzyl-1-thio-b-D-glucopyranoside)uronate | Methyl (phenyl 2,3-di-O-benzyl-1-thio-b-D-glucopyranoside)uronate is a pharmaceutically advanced biomedical compound, exhibiting unparalleled efficacy by precisely modulating intricate cellular mechanisms, thereby potentiating the impeding effect on malignant neoplastic cells. CAS No. 819798-56-6. Molecular formula: C27H28O6S. Mole weight: 480.6. | |
| Methyl (phenyl 2-O-benzoyl-3-O-benzyl-1-thio-a-L-idopyranosyluronate) | phenyl 2-O-benzoyl-3-O-benzyl-1-thio-a-L-idopyranosyluronate is an intricate compound recognized for its remarkable potential in arresting malignant growth. It assumes an indispensable position in drug formulation that specifically targets cancerous cells. Synonyms: Methyl (phenyl 2-O-benzoyl-3-O-benzyl-1-thio-a-L-idopyranoside)uronate. CAS No. 616876-73-4. Molecular formula: C27H26O7S. Mole weight: 494.56. | |
| Methylphenyl 2-O-benzyl-b-D-thiogalactopyranoside | Methylphenyl 2-O-benzyl-b-D-thiogalactopyranoside is a chemical compound commonly used in the biomedical industry. It serves as an inhibitor and substrate for enzyme assays, particularly in the study of galactosidases. This compound plays a crucial role in researching and understanding the mechanisms involved in the research of various diseases related to galactosidase deficiency. Molecular formula: C20H24O5S. Mole weight: 376.47. | |
| Metrazifone | Metrazifone is a potential bioactive agent and used as an analgesic drug. Uses: Metrazifone is used as an analgesic drug. Synonyms: Metrazifonum; ST-729; ST729; ST 729; 2-Methyl-3-oxo-5,6-di(paradimethylaminophenyl) as triazine. Grades: 98%. CAS No. 68289-14-5. Molecular formula: C20H23N5O. Mole weight: 349.44. | |
| Metrizamide | Metrizamide is a X-ray contrast agent related to Metrizoic Acid, used as a diagnostic aid (radiopaque medium). Uses: X-ray contrast agent related to metrizoic acid, used as a diagnostic aid (radiopaque medium). Synonyms: 2-[[3-(Acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl]amino]-2-deoxy-D-glucose; Metrizamide; Amipaque. Grades: ≥98%. CAS No. 31112-62-6. Molecular formula: C18H22I3N3O8. Mole weight: 789.10. | |
| Metronidazole β-D-Glucuronide | Metronidazole β-D-Glucuronide is a metabolite of Metronidazole. Synonyms: 2-(2-Methyl-5-nitro-1H-imidazol-1-yl)ethyl b-D-glucopyranosiduronic acid. Grades: > 95%. CAS No. 100495-98-5. Molecular formula: C12H17N3O9. Mole weight: 347.28. | |
| MHY219 | MHY219 is a novel HDAC inhibitor. MHY219 induces apoptosis via up-regulation of androgen receptor expression in human prostate cancer cells. MHY219 was shown to enhance the cytotoxicity on DU145 cells (IC50, 0.36 μM) when compared with LNCaP (IC50, 0.97 μM) and PC3 cells (IC50, 5.12 μM). MHY219 showed a potent inhibition of total HDAC activity when compared with SAHA. MHY219 increased histone H3 hyperacetylation and reduced the expression of class I HDACs (1, 2 and 3) in prostate cancer cells. MHY219 effectively increased the sub-G1 fraction of cells through p21 and p27 dependent pathways in DU145 cells. MHY219 significantly induced a G2/M phase arrest in DU145 and PC3 cells and arrested the cell cycle at G0/G1 phase in LNCaP cells. Furthermore, MHY219 effectively increased apoptosis in DU145 and LNCaP cells, but not PC3 cells, according to Annexin V/PI staining and Western blot analysis. These results indicate that MHY219 is a potent HDAC inhibitor that targets regulating multiple aspects of cancer cell death and might have preclinical value in human prostate cancer chemotherapy, warranting further investigation. Synonyms: MHY219; MHY-219; MHY 219. Grades: 98%. CAS No. 1326750-61-1. Molecular formula: C20H25N3O3. Mole weight: 355.43. | |
| MHY-684 | MHY-684 is a derivative of barbiturate and thiobarbiturate. Mouse model was used to evaluate its therapeutic effect of hair loss, and the mechanism is under studies. MHY-684 is hopefully used in cosmetics for the stimulating activity of hair growth. Uses: Stimulate activity of hair growth. Synonyms: MHY 684; MHY684. | |
| MHY-694 | MHY-694 is a derivative of barbiturate and thiobarbiturate. Mouse model was used to evaluate its therapeutic effect of hair loss, and the mechanism is under studies. MHY-684 is hopefully used in cosmetics for the stimulating activity of hair growth. Uses: Stimulate activity of hair growth. Synonyms: MHY 694; MHY694. | |
| MHY-700 | MHY-700 is a derivative of barbiturate and thiobarbiturate. Mouse model was used to evaluate its therapeutic effect of hair loss, and the mechanism is under studies. MHY-684 is hopefully used in cosmetics for the stimulating activity of hair growth. Uses: Stimulate activity of hair growth. Synonyms: MHY-700; MHY 700. | |
| Migalastat HCl | Migalastat HCl, also known as AT1001 or GR181413A, is a pharmacological chaperone that selectively binds, stabilizes, and increases cellular levels of α-Gal A. Oral administration of migalastat HCl reduces tissue GL-3 in Fabry transgenic mice, and in urine and kidneys of some FD patients. Migalastat HCl may provide a potential novel genotype-specific treatment for Fabry Disease (FD). Phase 3 studies are ongoing. Fabry disease (FD) is a genetic disorder resulting from deficiency of the lysosomal enzyme α-galactosidase A (α-Gal A) which leads to globotriaosylceramide (GL-3) accumulation in multiple tissues. Synonyms: 1,5-Dideoxy-1,5-imino-D-galactitol HCl; DGJ; (2R,3S,4R,5S)-2-methylolpiperidine-3,4,5-triol hydrochloride; Migalastat hydrochloride; Amigal. Grades: 98%. CAS No. 75172-81-5. Molecular formula: C6H13NO4.HCl. Mole weight: 199.63. | |
| Miglitol | Miglitol is an oral anti-diabetic drug. Uses: 1-deoxynojirimycin; analogs & derivatives; alpha-glucosidases; antagonists & inhibitors; enzyme inhibitors. Synonyms: Miglitol; Glyset. Grades: >98%. CAS No. 72432-03-2. Molecular formula: C8H17NO5. Mole weight: 207.22. | |
| Miglustat | Miglustat is an inhibitor of the ceramide-specific glycosyltransferase, which catalyzes the first step of glycosphingolipid biosynthesis and is currently approved for the oral treatment of type I Gaucher disease (GD1). Uses: Enzyme inhibitors. Synonyms: Zavesca; Miglustat; NB-DNJ. Grades: >98%. CAS No. 72599-27-0. Molecular formula: C10H21NO4. Mole weight: 219.28. | |
| Minalrestat | Minalrestat is an aldose reductase inhibitor originated by Wyeth. In Aug 2002, Phase-III for Diabetic retinopathy was discontinued in USA and Europe. Uses: Diabetic retinopathy. Synonyms: Minalrestat, ARI-509; WAY-121509; WAY-ARI-509; WAYARI-509; ARI509; WAY121509; WAYARI-509; WAYARI509; Minalrestat [USAN:INN];2-[(4-bromo-2-fluorophenyl)methyl]-6-fluorospiro[isoquinoline-4,3'-pyrrolidine]-1,2',3,5'-tetrone. Grades: 98%. CAS No. 129688-50-2. Molecular formula: C19H11BrF2N2O4. Mole weight: 449.21. | |
| Minoxidil β-D-Glucuronide | Minoxidil β-D-Glucuronide is a metabolite of Minoxidil, an antihypertensive and antialopecia agent. Minoxidil activates ATP-activated K+ channels. Synonyms: 6-(1-Piperidinyl)-2,4-pyrimidinediamine-3-oxide Glucuronide; 1-[[4-Amino-2-imino-6-(1-piperidinyl)-1(2H)-pyrimidinyl]oxy]-1-deoxy-β-D-glucopyranuronic Acid. Grades: > 95%. CAS No. 56828-40-1. Molecular formula: C15H23N5O7. Mole weight: 385.37. | |
| Mirabegron M14 (YM-554028) | Mirabegron O-Glucuronide is a metabolite of Mirabegron. Synonyms: Mirabegron O-Glucuronide; (1R) -2-[[2-[4-[[2- (2-Amino-4-thiazolyl) acetyl]amino]phenyl]ethyl]amino]-1-phenylethyl-β -D-glucopyranosiduronic Acid. Grades: > 95%. CAS No. 1365244-65-0. Molecular formula: C27H32N4O8S. Mole weight: 572.63. | |
| Mirabegron N-glucuronide | Mirabegron N-glucuronide is an exclusive metabolite derived from Mirabegron, a pharmaceutical compound commonly employed to study overactive bladder syndrome. Synonyms: Mirabegron N-glucuronide; Mirabegron (m14); 1365244-68-3; UNII-8Y8XEI3LHC; 8Y8XEI3LHC; YM-554028; (2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[[4-[2-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]anilino]-2-oxoethyl]-1,3-thiazol-2-yl]amino]oxane-2-carboxylic acid; beta-D-Glucopyranuronic acid, 1-deoxy-1- ( (4- (2- ( (4- (2- ( ( (2R) -2-hydroxy-2-phenylethyl) amino) ethyl) phenyl) amino) -2-oxoethyl) -2-thiazolyl) amino) -; CHEMBL3548562; J-006859; Q27271202.BETA.-D-GLUCOPYRANURONIC ACID, 1-DEOXY-1- ( (4- (2- ( (4- (2- ( ( (2R) -2-HYDROXY-2-PHENYLETHYL) AMINO) ETHYL) PHENYL) AMINO) -2-OXOETHYL) -2-THIAZOLYL) AMINO) -. CAS No. 1365244-68-3. Molecular formula: C27H32N4O8S. Mole weight: 572.6. | |
| Mirin | Mirin is an MRN-ATM pathway inhibitor, inhibiting MRN-dependent activation of ATM without affecting ATM protein kinase activity and Mre11-associated exonuclease activity. Mirin also inhibits the G2/M checkpoint and homology-dependent repair in mammalian cells. Synonyms: 2-amino-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one. Grades: ≥95%. CAS No. 299953-00-7. Molecular formula: C10H8N2O2S. Mole weight: 220.3. | |
| Miroprofene | Miroprofen is an analgesic and NSAID. It is a carbocyclic acid and a phenylpropionate. It has anti-inflammatory, antipyretic and antiplatelet aggregation activity. Uses: Miroprofen is an analgesic and nsaid. it has anti-inflammatory, antipyretic and antiplatelet aggregation activity. Synonyms: Miroprofeno; Miroprofenum; Antopen; Y-9213; Y 9213; Y9213; 2-[p-(Imidazo[1,2-a]pyridin-2-yl)phenyl]propionic acid; 4-(Imidazo[1,2-a]pyridin-2-yl)-α-methylbenzeneacetic acid. Grades: 98%. CAS No. 55843-86-2. Molecular formula: C16H14N2O2. Mole weight: 266.30. | |
| Mirvetuximab | Mirvetuximab is a monoclonal antibody that binds to folate receptor 1. Mirvetuximab has been used in the research of FRα-expressing ovarian cancer. Synonyms: M9346A. CAS No. 1453084-36-0. | |
| Mitiglinide-acyl-b-D-glucuronide | Mitiglinide-acyl-b-D-glucuronide is a highly efficacious pharmaceutical compound extensively employed, aiding in the research of type 2 diabetes mellitus. This compound exerts an augmented stimulatory effect on insulin secretion. Molecular formula: C25H33NO9. Mole weight: 491.53. | |
| MitMAB | MitMAB, an organic building block and cationic surfactant, is a dynamin inhibitor that inhibits the GTPase activity of dynamin I (Ki = 940 nM; IC50=3.1 μM). It has been used in a study to assess a surfactant-controlled synthetic method to obtain a nanophase of mesoporous ceria-zirconia solid solution containing cationic defects in the crystalline structure. Uses: Quaternary ammonium compounds are used in disinfectants and sanitizers to treat swimming pools and industrial water reservoirs, as antiseptics for cleaning wounds, skin, and burns, in hair conditioners, as softeners for textiles and paper, and as pigment dispersers. Synonyms: Tetradecyltrimethylammonium bromide; (1-Tetradecyl)trimethylammonium Bromide Cetrimide BP; MTAB ; Microcide II; Morpan T; Myristyltrimethylammonium bromide; Myrtrimonium Bromide; Mytab; N,N,N-Trimethyl-1-tetradecanaminium Bromide;N-Tetradecyl-N,N,N-trimethylammonium Bromide; Pentonium 4Br40;Quaternium 13; Querton 14Br40; TTAB; TTAB (surfactant); Tetradecyltrimethylammonium Bromide; Tetradonium Bromide; Trimethylmyristylammonium Bromide; n-Tetradecyltrimethylammonium Bromide. Grades: >98.0%(T). CAS No. 1119-97-7. Molecular formula: C17H38BrN. Mole weight: 336.39. | |
| Mitobronitol | 1,6-Dibromo-1,6-dideoxy-D-mannitol is a mannitol derivative with bromides substituted for the terminal hydroxyl groups. Synonyms: 1,6-Dibromo-1,6-dideoxy-D-mannitol; Myebrol; 1,6-Dibromomannitol; 1,6-Dibromomannitol; Dibromannitol; NSC-94100. Grades: >98%. CAS No. 488-41-5. Molecular formula: C6H12Br2O4. Mole weight: 307.97. | |
| Mitoguazone | Mitoguazone is a guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. Synonyms: MeGAG; methyl-G; methyl-GAG; MGBG; MGGH; DRG-0223; DRG 0223; DRG0223; NSC32946; NSC 32946; NSC-32946. Grades: 99.38%. CAS No. 459-86-9. Molecular formula: C5H12N8. Mole weight: 184.21. | |
| Mitoquinone mesylate, ethanol solution | Cas No. 845959-50-4. | |
| Mivobulin isethionate | Mivobulin isethionate is the isethionate salt of mivobulin, a synthetic colchicine analogue with potential antineoplastic activity. Mivobulin isethionate binds to tubulin, thereby inhibiting microtubule polymerization and mitosis. Uses: Antineoplastic agents. Synonyms: CI-980; CI 980; CI980. CAS No. 126268-81-3. Molecular formula: C19H25N5O6S. Mole weight: 451.50. | |
| Mizoribine 5-monophosphate | Mizoribine 5-monophosphate is a widely utilized pharmaceutical compound within the biomedical sector, aiding in studying diverse autoimmune disorders, such as rheumatoid arthritand lupus nephritis. CAS No. 62025-48-3. Mole weight: 259.22. | |
| MK-0354 | MK-0354 is a partial agonist of Niacin receptor, G-protein coupled receptor 109a. Its EC50 value is 1.65/1.08 μM for hGPR109a/ mGPR109a, which show no activation of GPR109b in the cAMP assay at any concentration up to 100 μM. It demonstrated clear and statistically significant partial agonism in the cAMP assays for both the mouse and human receptors with efficacy approximately 60-70% of that of either nicotinic acid or β-hydroxy butyrate in vitro. It appeared to be somewhat unique among the members of the pyrazole tetrazole series in having reasonable receptor activity. It retained the plasma free fatty acid lowering effects in mice, but did not induce vasodilation at the maximum feasible dose in vivo. It could activate the antilipolytic pathway in adipocytes. It was developed by Arena pharmaceuticals and Merck Serono together. It had been in the two phase of clinical and been used for the treatment of atherosclerosis, but it was terminated in 2006. Uses: Mk-0354 could activate the antilipolytic pathway in adipocytes. had been used for the treatment of atherosclerosis. Synonyms: MK-0354; MK0354; MK 0354; 3-(1H-tetrazol-5-yl)-1, 4, 5, 6-tetrahydrocyclopenta[c]pyrazole;1, 4, 5, 6-Tetrahydro-3-(1H-tetrazol-5-yl)cyclopenta[c]pyrazole. Grades: >98%. CAS No. 851776-28-8. Molecular formula: C7H8N6. Mole weight: 176.18. | |
| MK-0429 | MK-0429 is a potent alpha(nu)beta(3) integrin inhibitor (or αvβ3 inhibitor), which showed therapeutic effects on bone turnover disease in men with hormone-refractory prostate cancer (HRPC) and bone metastases. Clinical trial results showed that MK-0429 was generally well tolerated, with the most common side-effect being nausea. There was some evidence of an early reduction of bone turnover, indicating a potential for clinical use in the treatment of bone mineral density (MBD) although serum PSA was unexpectedly increased during the study. Synonyms: L-000845704; (S)-3-(6-methoxypyridin-3-yl)-3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid; NSC776790; 3-Pyridinepropanoic acid, 6-methoxy-β-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]-, (βS)-. Grades: >98%. CAS No. 227963-15-7. Molecular formula: C23H29N5O4. Mole weight: 439.51. | |
| MK0533 | MK0533 is a novel selective peroxisome proliferator-activated receptor gamma modulator. It is used for the treatment of type 2 diabetes mellitus. It reduces potential to increase plasma and extracellular fluid volume. It showed diminished maximal activity in cell-based transcription activation assays and attenuated gene signatures in adipose tissue. Uses: Mk0533 is used for the treatment of type 2 diabetes mellitus. Synonyms: MK-0533; MK 0533; (R)-2-(3-(3-(4-methoxybenzoyl)-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl)phenoxy)butanoic acid. Grades: 98%. CAS No. 668455-28-5. Molecular formula: C28H24F3NO6. Mole weight: 527.50. | |
| MK-0668 | MK-0668 is an antagonist of very late antigen-4 with picomolar, whole blood activity and slow dissociation rates were discovered by incorporating an amino substituent on the proline fragment of the initial lead structure. Synonyms: MK0668; MK 0668; MK-0668; (S) -2- ( (2S, 4R) -1- ( (3-cyanophenyl) sulfonyl) -4- (cyclobutylamino) pyrrolidine-2-carboxamido) -3- (4- (3, 5-dichloroisonicotinamido) phenyl) propanoic acid. Grades: 98%. CAS No. 865110-07-2. Molecular formula: C31H30Cl2N6O6S. Mole weight: 685.59. | |
| MK-0668 mesylate | MK-0668 is an antagonist of very late antigen-4 with picomolar, whole blood activity and slow dissociation rates were discovered by incorporating an amino substituent on the proline fragment of the initial lead structure. Synonyms: MK0668; MK 0668; MK-0668; (S) -2- ( (2S, 4R) -1- ( (3-cyanophenyl) sulfonyl) -4- (cyclobutylamino) pyrrolidine-2-carboxamido) -3- (4- (3, 5-dichloroisonicotinamido) phenyl) propanoic acid mesylate. Grades: 98%. CAS No. 865111-04-2. Molecular formula: C31H30Cl2N6O6S.CH4O3S. Mole weight: 781.69. | |
| MK-0752 | MK 0752 is a potent and reversible inhibitor of γ-secretase (IC50 ~50 nM). It was shown to reduce the number of breast cancer stem cells in tumorgrafts. Uses: Gamma secretase inhibitors and modulators. Synonyms: Cyclohexanepropanoic acid, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, cis-; cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid; MK 0752; MK0752. Grades: >98%. CAS No. 471905-41-6. Molecular formula: C21H21ClF2O4S. Mole weight: 442.91. | |
| MK0916 | MK0916 is an 11β-hydroxysteroid dehydrogenase type 1 inhibitor. It is used for patients with type 2 diabetes mellitus and metabolic syndrome and obesity-related disorders. It produces mechanism-based activation of the hypothalamic-pituitary-adrenal axis and results in mean increases in adrenal androgen levels that remains within the normal range. Uses: Mk0916 is used for patients with type 2 diabetes mellitus and metabolic syndrome and obesity-related disorders. Synonyms: MK 0916; MK-0916; 3-((1s,3s)-1-(4-chlorophenyl)-3-fluorocyclobutyl)-4,5-dicyclopropyl-4H-1,2,4-triazole. Grades: 98%. CAS No. 633317-53-0. Molecular formula: C18H19ClFN3. Mole weight: 331.82. | |
| Mk1064 | Mk1064 is a selective orexin OX2 receptor antagonist for potential treatment of insomnia. Studies shows that Mk1064 could promote sleep and increase both rapid eye movement (REM) and non-REM (NREM) sleep of humans. Uses: Mk1064 is a selective orexin ox2 receptor antagonist. Synonyms: MK1064; MK 1064; MK-1064; 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide. Grades: ≥98%. CAS No. 1207253-08-4. Molecular formula: C24H20ClN5O3. Mole weight: 461.91. | |
| MK 1903 | MK 1903 is a hydroxycarboxylic acid receptor 2 (GPR109A) agonist. It may be used in the treatment of obesity and related weight disorders. Synonyms: MK 1903; MK1903; MK-1903; (4aR, 5aR)-4, 4a, 5, 5a-Tetrahydro-1H-cyclopropa[4, 5]cyclopenta[1, 2]pyrazole-3-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 1268882-43-4. Molecular formula: C8H8N2O2. Mole weight: 164.16. | |
| MK-251 | MK-251 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: MK 251; MK251; alpha,alpha-Dimethyl-4-(alpha,alpha,beta,beta-tetrafluorophenethyl)benzylamine. Grades: ≥98%. CAS No. 40396-83-6. Molecular formula: C17H17F4N. Mole weight: 311.32. | |
| MK-3207 | MK-3207 is a orally active and potent calcitonin gene-related peptide (CGRP) receptor antagonist IC50 vaule of 0.12 nM and Ki value of 0.024 nM. It is highly selective versus human AM1, AM2, CTR, and AMY3. It displays lower affinity for human CGRP receptors from other species, including canine and rodent. It is a potent antagonist of the human and rhesus monkey CGRP receptors in vitro. It produced a concentration-dependent inhibition of dermal vasodilation in vivo. It is effective acute migraine treatments. It was developed by Merck & Co., Inc. and was terminated in clinic phase 2. Uses: Mk-3207 is effective acute migraine treatments. Synonyms: MK3207; MK 3207; MK-3207; 2-[(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]decan-9-yl]-N-[(2R)-2'-oxospiro[1,3-dihydroindene-2,3'-1H-pyrrolo[2,3-b]pyridine]-5-yl]acetamide;(8R)-8-(3,5-Difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospirv [4.5]decane-9-acetamide;6,9-Diazaspiro[4.5]decane-9-acetaMide,8-(3,5-difluorophenyl)-10-oxo-N-[(2R)-1,1',2',3-tetrahydro-2'-oxospiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-,(8R)-. Grades: >98 %. CAS No. 957118-49-9. Molecular formula: C31H29F2N5O3. Mole weight: 557.59. | |
| MK-3207 HCl | MK-3207 is a potent CGRP receptor antagonist with IC50 and Ki of 0.12 nM and 0.022 nM, highly selective versus human AM1, AM2, CTR, and AMY3. Synonyms: MK-3207 HCl; MK 3207 HCl; MK3207 HCl. Grades: >98%. CAS No. 957116-20-0. Molecular formula: C31H29F2N5O3·HCl. Mole weight: 594.05. | |
| MK-5172 intermediate | Cas No. 1206524-85-7. | |
| MK-6892 | MK-6892 is a highly potential GPR109A agonist. Synonyms: MK6892; MK 6892; MK-6892. Grades: >98%. CAS No. 917910-45-3. Molecular formula: C19H22N4O5. Mole weight: 386.4. | |
| MK-711 | MK-711 is used as a potential bioactive agent. Uses: Mk-711 is used as a potential bioactive agent. Synonyms: MK 711; MK711; 10,11-Dihydro-5-(1-methyl-4-piperidinylidene)-5H-dibenzo(a,d)cycloheptene-3-carboxylic acid; 5-(1-methylpiperidin-4-ylidene)-10,11-dihydro-5H-dibenzo[a,d][7]annulene-3-carboxylic acid. Grades: 98%. CAS No. 63141-67-3. Molecular formula: C22H23NO2. Mole weight: 333.43. | |
| MK-7246 | This active molecular is a selective chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist and is used for the treatment of respiratory tract disorders originated by Merck & Co. CRTH2 is a G protein-coupled receptor that has been reported to modulate inflammatory responses in animal models of asthma, allergic rhinitis and atopic dermatitis. No recent reports of development identified for phase-I development in Respiratory-tract-disorders in USA were published yet. Uses: Respiratory tract disorders. Synonyms: MK-7246; MK 7246; MK7246; (7R)-7-[[(4-Fluorophenyl)sulfonyl]methylamino]-6,7,8,9-tetrahydro-pyrido[1,2-a]indole-10-acetic Acid. Grades: 98%. CAS No. 1218918-62-7. Molecular formula: C21H21FN2O4S. Mole weight: 416.47. | |
| MK-771 | MK-771 is an analog of the Thyrotropin Releasing Hormone (TRH). It is a therapeutic agent. It may be useful in combating some of the withdrawal symptoms in opiate-dependent subjects. Uses: Mk-771 is a therapeutic agent. it may be useful in combating some of the withdrawal symptoms in opiate-dependent subjects. Synonyms: MK771; MK 771; (S)-3-((S)-3-(1H-imidazol-4-yl)-2-((S)-6-oxopiperidine-2-carboxamido)propanoyl)thiazolidine-4-carboxamide. Grades: 98%. CAS No. 66537-55-1. Molecular formula: C16H22N6O4S. Mole weight: 394.45. | |
| MK7725 | MK7725 is a potent, selective bombesin receptor subtype-3 agonist. It is used for the treatment of obesity. Uses: Mk7725 is used for the treatment of obesity. Synonyms: MK7725; MK 7725; MK-7725; 2-[3-[6-[4-(trifluoromethoxy)phenyl]sulfonyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl]propan-2-ol. Grades: >98 %. CAS No. 1034152-95-8. Molecular formula: C25H19F6N5O5S. Mole weight: 615.50. | |
| MK789 | MK-789 is a dehydropeptidase I inhibitor. Synonyms: MK789; MK 789; MK-789; (E)-2-(2,2-dimethylcyclopropanecarboxamido)oct-2-enoic acid. Grades: 98%. CAS No. 85394-14-5. Molecular formula: C14H23NO3. Mole weight: 253.34. | |
| MK940 | MK940 is a potential central nervous system agent. It is used as an anti-depressant. Uses: Mk940 is used as an anti-depressant. Synonyms: MK-940; MK 940; 5-[3-(Methylamino)propyl]-10,11-dihydro-5H-5,10-epoxydibenzo[a,d][7]annulen-11-ol; trans-10,11-Dihydro-5,10-epoxy-5-(3-(methylamino)propyl)-5H-dibenzo(a,d)cyclohepten-11-ol hydrogen maleate. Grades: 98%. CAS No. 5154-92-7. Molecular formula: C19H21NO2. Mole weight: 295.38. | |
| MKC-1 | MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. In addition, this agent has been shown to inhibit the activities of the oncogenic kinase Akt, the mTOR pathway, and importin-beta, a protein essential to the transport of other proteins from the cytosol into the nucleus. Synonyms: MKC1; MKC 1; R 440; Ro 317453; Ro-317453; Ro317453; 3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-1H-pyrrole-2,5-dione. CAS No. 125313-92-0. Molecular formula: C22H16N4O4. Mole weight: 400.39. | |
| MKI-833 | MKI 833 is a small molecule inhibitor of the MEK/MAPK pathway. Synonyms: Balamapimod; MKI 833; MKI833; 3-Quinolinecarbonitrile, 4-[[3-chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]phenyl]amino]-6-methoxy-7-[4-(1-pyrrolidinyl)-1-piperidinyl]-. CAS No. 863029-99-6. Molecular formula: C30H32ClN7OS. Mole weight: 574.14. | |
| ML-097 | ML-097 is a pan activator of Ras-related GTPases. Synonyms: ML 097; ML097; CID-2160985; 2-[(2-bromophenyl)methoxy]benzoic acid; 2-[(2-bromobenzyl)oxy]benzoic acid. Grades: ≥95%. CAS No. 743456-83-9. Molecular formula: C14H11BrO3. Mole weight: 307.1. | |
| ML-099 | ML-099 is a pan activator of Ras-related GTPases. Synonyms: ML 099; ML099; CID-888706; 2-[(2-Phenylethyl)thio]nicotinic acid. Grades: ≥98%. CAS No. 496775-95-2. Molecular formula: C14H13NO2S. Mole weight: 259.3. | |
| ML130 | ML130 (Nodinitib-1) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2. Synonyms: ML 130; ML-130; Nodinitib-1; Noditinib-1; 1-Tosyl-1H-benzo[d]imidazol-2-amine. Grades: >98%. CAS No. 799264-47-4. Molecular formula: C14H13N3O2S. Mole weight: 287.34. | |
| ML-132 | ML132, also known as CID-4462093 or NCGC-00183434, is the most potent caspase 1 inhibitor reported to date. It also possesses a unique selectivity pattern relative to other reported caspase inhibitors. Synonyms: NCGC 00185682; ML132; ML 132; N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(1S)-2-carboxy-1-cyanoethyl]-L-prolinamide; L-Prolinamide, N-(4-amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(1S)-2-carboxy-1-cyanoethyl]-. Grades: ≥98%. CAS No. 1230628-71-3. Molecular formula: C22H28ClN5O5. Mole weight: 477.94. | |
| ML133 HCl | ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1. Synonyms: ML133 hydrochloride; (4-Methoxybenzyl)(1-naphthylmethyl)amine Hydrochloride; N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride. Grades: >98%. CAS No. 1222781-70-5. Molecular formula: C19H19NO.HCl. Mole weight: 313.82. | |
| ML 161 | Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 muM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation. Synonyms: ML-161; ML161; Parmodulin 2; 2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]benzamide. CAS No. 423735-93-7. Molecular formula: C17H17BrN2O2. Mole weight: 361.24. | |
| ML167 | ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B. Synonyms: CID44968231; NCGC00188654; [5-[4-[(5-methyl-2-furanyl)methylamino]-6-quinazolinyl]-2-furanyl]methanol; 2-Furanmethanol, 5-[4-[[(5-methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-. Grades: >98%. CAS No. 1285702-20-6. Molecular formula: C19H17N3O3. Mole weight: 335.36. | |
| ML 18 | ML 18 is a bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM) and binds GRPR (IC50 = 16 μM) with potential in combating lung cancer cells. Synonyms: ML-18; ML 18; ML18. 1H-Indole-3-propanamide, N-[[1- (4-methoxyphenyl) ?cyclohexyl]?methyl]?-α -[[[ (4-nitrophenyl) ?amino]?carbonyl]?amino]?-, (αS)?-; (αS)-N-[[1-(4-Methoxyphenyl)cyclohexyl]methyl]-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-1H-indole-3-propanamide. CAS No. 1422269-30-4. Molecular formula: C32H35N5O5. Mole weight: 569.65. | |
| ML 210 | ML 210 is a selective RAS inhibitor that kills cells induced to express mutant RAS. ML210 exhibits nanomolar potency against two HRASG12V expressing cell lines and 4-fold selectivity against two control cell lines not expressing HRASG12V. Synonyms: CID 49766530; CID-49766530; CID49766530; ML-210; ML 210; ML210. [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-methanone. Grades: 99%. CAS No. 1360705-96-9. Molecular formula: C22H20Cl2N4O4. Mole weight: 475.32. | |
| ML309 | ML309 is a potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG glioblastoma cells. ML309 is capable of potent and selective inhibition of mutant IDH1 and effectively lowers cell-based production of 2-HG in a U87MG mutant glioblastoma cell line. Synonyms: ML-309; ML 309. Grades: 98%. CAS No. 1355446-05-7. Molecular formula: C29H29FN4O2. Mole weight: 484.56. | |
| ML3403 | ML 3403 is a potent and selective p38 mitogen-activated protein kinase (MAPK) inhibitor. MAPK is a key mediator in cytokine-induced signaling events and plays an integral role in disease states including oncogenesis, autoimmune diseases, and inflammatory processes. Therefore, MAPK inhibitors such as ML 3403 provides an attractive strategy for therapeutic intervention. Synonyms: ML 3403; ML-3403; p38 MAP Kinase Inhibitor III; 4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)-N-(1-phenylethyl)pyridin-2-amine. Grades: 98%. CAS No. 549505-65-9. Molecular formula: C23H21FN4S. Mole weight: 404.51. | |
| ML347 | ML347 is a selective BMP receptor inhibitor with IC50 value of 32 nM for ALK2, >300-fold selectivity over ALK3. It also inhibits ALK1 activity with IC50 value of 46 nM. Synonyms: ML-347; 5-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline. Grades: >98%. CAS No. 1062368-49-3. Molecular formula: C22H16N4O. Mole weight: 352.39. | |
| ML367 | ML367 is an effective inhibitor for the stabilization of micromolar ATPase family AAA domain containing protein 5 (ATAD5), and can be used as a probe molecule with low micromolar inhibitory activity. Synonyms: NCGC00262816-01; CBMicro_009721; ChemDiv1_005670; Oprea1_377205; MLS000591778. Grades: 98%. CAS No. 381168-77-0. Molecular formula: C19H12F2N4. Mole weight: 334.3. | |
| ML401 | ML401 is a selective EBI2 (GPR183) receptor antagonist (IC50 of 1.03 nM). Grades: 98%. CAS No. 1597489-14-9. Molecular formula: C20H20BrClN2O. Mole weight: 419.7. | |
| ML-7 | ML-7 is a potent and selective inhibitor of myosin light chain(MLC) kinase with Ki value of 0.3 μM. It has been shown to protect cardiac function from ischemia/reperfusion (I/R) injury. It inhibts smooth-muscle myosin light chain kinase, protein kinase C (PKC) and cAMP-dependent protein kinase (PKA). Uses: Ml-7 hydrochloride has been shown to protect cardiac function from ischemia/reperfusion (i/r) injury. Synonyms: ML7; ML 7; 1-[(5-iodo-1-naphthyl)sulfonyl]-1,4-diazepane. Grades: >98%. CAS No. 109376-83-2. Molecular formula: C15H17IN2O2S. Mole weight: 416.28. | |
| ML-9 | ML-9 is a myosin light chain kinase (MLCK) inhibitor. It enhances the anticancer activity of docetaxel and has potential application as an adjuvant to existing anticancer chemotherapy. It is used as an attractive tool for targeting autophagy in cancer therapy through dual inhibition of both the Akt pathway and the autophagy. Uses: Ml-9 has potential application as an adjuvant to existing anticancer chemotherapy. Synonyms: ML9; ML 9; 1H-1,4-Diazepine, 1-[(5-chloro-1-naphthalenyl)sulfonyl]hexahydro-. Grades: >98%. CAS No. 110448-31-2. Molecular formula: C15H17ClN2O2S. Mole weight: 324.82. | |
| ML-9 hydrochloride | ML-9 hydrochloride is a myosin light chain kinase (MLCK) inhibitor. It enhances the anticancer activity of docetaxel and may be used as an adjuvant to existing anticancer chemotherapy. It inhibits natural killer (NK) cell activity in a dose-dependent manner without affecting target cell binding. It inhibits insulin-induced translocation of both GLUT4 and GLUT1 in a dose-dependent manner. It also inhibits agonist-induced Ca2+ entry into endothelial cells and catecholamine secretion in intact and permeabilized chromaffin cells. It inhibits the catalytic activities of several protein kinases competitively with respect to ATP and exhibited different Ki values toward each protein kinase. It may be a new type of vascular relaxant. Uses: Ml-9 hydrochloride may be used as an adjuvant to existing anticancer chemotherapy. it may be a new type of vascular relaxant. Synonyms: ML9; ML-9; ML 9; ML9 Hydrochloride;ML 9 Hydrochloride; 1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine HCl;1-(5-Chloronaphthalen-1-yl)sulfonyl-1,4-diazepane hydrochloride. Grades: 95%. CAS No. 105637-50-1. Molecular formula: C15H18Cl2N2O2S. Mole weight: 361.29. | |
Our database is helping our users find suppliers everyday.
