BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Istaroxime | Istaroxime, also called as PST 2744, is an inhibitor of sodium-potassium ATPase that exhibits the unique property of increasing SERCA2a activity. This has been demonstrated in sarcoplasmic reticulum vesicles from normal guinea pigs, where istaroxime incre. Alternative Names: PST-2744; PST 2744; PST2744; Istaroxime; (3E,5S,8R,9S,10R,13S,14S)-3-(2-aminoethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione3-((2-aminoethoxy)imino)androstane-6,17-dione3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochlorideIstaroxi. CAS No. 203737-93-3. Molecular formula: C21H32N2O3. Mole weight: 360.49. |  |
| Istaroxime hydrochloride | Istaroxime is a adenosine triphosphatase inhibitor, inhibition of sodium / potassium adenosine triphosphatase (Na+/K+ ATPase). Uses: Inhibitor of na+/k+ atpase. Alternative Names: PST-2744 HCl; PST 2744 HCl; PST2744 HCl(3E,5α)-3-[(2-Aminoethoxy)imino]androstane-6,17-dione hydrochloride. Grades: ≥95%. CAS No. 374559-48-5. Molecular formula: C21H33ClN2O3. Mole weight: 396.95. | |
| Itaconic acid | Itaconic acid, a dicarboxylic acid with a molecular formula of C5H6O4, plays a pivotal role as a precursor in the synthesis of bio-based polymers essential for drug delivery and tissue regeneration applications. Furthermore, its pharmacological potential extends to the treatment of debilitating conditions like rheumatoid arthritis and osteoarthritis. Uses: Used in copolymerization and to make resins, plasticizers, and lube oil additives; used as a comonomer in the production of acrylic fibers and latex. Alternative Names: Butanedioic acid, 2-methylene-; Butanedioic acid, methylene-; Succinic acid, methylene-; 2-Methylenesuccinic acid; 2-Methylidenebutanedioic acid; 2-Propene-1,2-dicarboxylic acid; 4-Hydroxy-2-methylene-4-oxobutanoic acid; Methylenebutanedioic acid; Methylenesuccinic acid; NSC 3357; Propylenedicarboxylic acid. Grades: ≥95%. CAS No. 97-65-4. Molecular formula: C5H6O4. Mole weight: 130.10. | |
| ITE | ITE is an Aryl hydrocarbon receptor ligand that acts as an endogenous aryl hydrocarbon receptor (AhR) agonist (Ki = 3 nM). Uses: Endogenous aryl hydrocarbon receptor (ahr) agonist. Alternative Names: 2-(1H-Indol-3-ylcarbonyl)-4-thiazolecarboxylic acid methyl ester. Grades: ≥98 %. CAS No. 448906-42-1. Molecular formula: C14H10N2O3S. Mole weight: 286.31. | |
| ITI214 | ITI214 is a highly selective PDE1 inhibitor (Ki = 58 pM) at picomolar concentration without disrupting other PDE family members and a panel of enzymes, receptors, transporters, and ion channels. Alternative Names: Lenrispodun phosphate; PDE1-IN-1 (phosphate); ITI 214; ITI-214. CAS No. 1642303-38-5. Molecular formula: C29H29FN7O5P. Mole weight: 605.56. | |
| ITK inhibitor | ITK inhibitor is a potent inhibitor of ITK. Alternative Names: ITK inhibitor; 439574-61-5; N-[5-[5-(4-acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl]sulfanyl-1,3-thiazol-2-yl]-4-[(3-methylbutan-2-ylamino)methyl]benzamideBENZAMIDE, N-[5-[[5-[(4-ACETYL-1-PIPERAZINYL)CARBONYL]-4-METHOXY-2-METHYLPHENYL]THIO]-2-THIAZOLYL]-4-[[(1,2-DIMETHYLPROPYL)AMINO]METHYL]-SCHEMBL14460568. Grades: >98%. CAS No. 439574-61-5. Molecular formula: C31H39N5O4S2. Mole weight: 609.82. | |
| Itolizumab | Itolizumab is a monoclonal antibody used in the treatment of autoimmune diseases, particularly in the context of severe plaque psoriasis and other immune-mediated conditions. Itolizumab targets and binds to the CD6 receptor, a protein present on the surface of T cells, which are key players in the immune response. By binding to CD6, itolizumab modulates T cell activation and function, thereby reducing the inflammatory response seen in autoimmune diseases. It is primarily used for the treatment of moderate to severe plaque psoriasis in adults who have not responded well to other systemic therapies. It has also shown efficacy in other autoimmune conditions, such as rheumatoid arthritis and psoriatic arthritis. Alternative Names: Immunoglobulin G1, anti-(human antigen CD6) (human-mouse monoclonal T1h heavy chain), disulfide with human-mouse monoclonal T1h light chain, dimer; ALZUMAb; EQ 001. CAS No. 1116433-11-4. | |
| Itraconazole | Itraconazole, a triazole antifungal agent, is a relatively potent inhibitor of CYP3A4. Uses: Antifungal agents; antiprotozoal agents. Alternative Names: Itraconazole; R51211; R 51211; R-51211; Orungal; Oriconazole; Sporanox; Itraconazolum; Itraconazol; Itrizole. Grades: >98%. CAS No. 84625-61-6. Molecular formula: C35H38Cl2N8O4. Mole weight: 705.63. | |
| Itraconazole N-Formyl-Ethlene Impurity | Impurity of Itraconazole. Alternative Names: Itraconazole Desethylene-seco-piperazine Mono-N-formyl Impurity; N-(4-(((2R,4S)-2-((1H-1,2,4-Triazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-N-(2-((4-(1-(sec-butyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)amino)ethyl)formamide. Grades: > 95%. CAS No. 1199350-00-9. Molecular formula: C34H36Cl2N8O5. Mole weight: 707.62. | |
| Itrocinonide | Itrocinonide, a remarkable synthetic glucocorticoid harnessed in the research of biomedicine, undeniably manifests an exquisite repertoire of anti-inflammatory and immunosuppressive capabilities. Alternative Names: Androsta-1,4-diene-17-carboxylicacid, 16,17-[(1R)-butylidenebis(oxy)]-6,9-difluoro-11-hydroxy-3-oxo-,(1S)-1-[(ethoxycarbonyl)oxy]ethyl ester, (6a,11b,16a,17a)-. Grades: > 95%. CAS No. 106033-96-9. Molecular formula: C29H38F2O9. Mole weight: 568.62. | |
| ITX-5061 HCl | This active molecular is a scavenger receptor B1 antagonist under the development by iTherX Pharmaceuticals for the treatment of Hepatitis C. ITX-5061 shows a special mechanism of action that prevents the hepatitis C virus from entering liver cells. Preclinical studies have shown that ITX-5061 can prevent virus binding / fusion and cell to cell spread. In Jan 2015, Phase-II clinical trials in Hepatitis C in USA was on-going. Uses: Hepatitis c. Alternative Names: ITX-5061; ITX 5061; ITX5061; UNII-J4RA8K2Q2A; J4RA8K2Q2A;CHEMBL3402567;N-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-2-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]-2-oxoacetamide;hydrochloride;848144-15-0 (free base). Grades: 98%. CAS No. 1252679-52-9. Molecular formula: C30H38ClN3O7S. Mole weight: 620.16. | |
| i-Urobilinogen | i-Urobilinogen is a member of the class of bilanes that is a colorless product formed in the intestine by the reduction of bilirubin. It has a role as a human metabolite. Alternative Names: 21H-Biline-8,12-dipropanoic acid, 2,17-diethyl-1,4,5,10,15,16,19,22,23,24-decahydro-3,7,13,18-tetramethyl-1,19-dioxo-; Biline-8,12-dipropionic acid, 2,17-diethyl-1,4,5,10,15,16,19,22,23,24-decahydro-3,7,13,18-tetramethyl-1,19-dioxo-; 3-(2-((3-(2-Carboxyethyl)-5-((3-ethyl-4-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)methyl)-4-methyl-1H-pyrrol-2-yl)methyl)-5-((4-ethyl-3-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl)methyl)-4-methyl-1H-pyrrol-3-yl)propanoic acid; Mesobilirubinogen; Urobilinogen IXalpha; Mesobilirubinogen IXalpha. Grades: ≥95%. CAS No. 14684-37-8. Molecular formula: C33H44N4O6. Mole weight: 592.74. | |
| Ivabradine R-Isomer HCl | The enantiomer of Ivabradine Hydrochloride. Ivabradine is a medication used to reduce the risk of hospitalization for worsening heart failure in adult patients with stable, symptomatic chronic heart failure. Alternative Names: ent-Ivabradine Hydrochloride; 3-[3-[[[(7R)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride. Grades: > 95%. CAS No. 148849-68-7. Molecular formula: C27H37ClN2O5. Mole weight: 505.06. | |
| Ivacaftor | Ivacaftor is a potentiator of CFTR targeting G551D-CFTR(EC50=100 nM)and F508del-CFTR(EC50=25 nM). Ivacaftor is used in the treatment of cystic fibrosis. Uses: Chloride channel agonists. Alternative Names: N-[2,4-Bis[1,1-di(methyl)ethyl]-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide; Ivacaftor; Kalydeco; VX-770; VX 770; VX770. Grades: 98%. CAS No. 873054-44-5. Molecular formula: C24H28N2O3. Mole weight: 392.49. | |
| Ivacaftor Impurity 2 | an impurity of Ivacaftor. Alternative Names: Hydroxymethyl Ivacaftor; N-[2-(1,1-Dimethylethyl)-5-hydroxy-4-(2-hydroxy-1,1-dimethylethyl)phenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide. Grades: > 95%. CAS No. 1246213-23-9. Molecular formula: C24H28N2O4. Mole weight: 408.50. | |
| Ivy, Hedera helix, ext. | Ivy, Hedera helix, ext., also known as Ivy Leaf Extract, is derived from the leaves and stems of the Hedera helix plant, a climbing evergreen vine native to Europe, Asia, and North Africa and is rich in bioactive compounds such as saponins, flavonoids, and phenolic acids which contribute to its medicinal and cosmetic properties. Widely used for its expectorant and antitussive properties, Ivy, Hedera helix, ext. is a common ingredient in cough syrups and medications for respiratory conditions such as bronchitis, asthma, and chronic cough while also having anti-inflammatory and antimicrobial effects that can help reduce inflammation and treat skin conditions like eczema and psoriasis. Additionally, the extract contains antioxidants that help protect cells from oxidative damage. In cosmetics, Ivy, Hedera helix, ext. is used as a skin protectant and conditioning agent helping to soothe and moisturize the skin while providing antioxidant benefits with recommended concentrations up to 1% for leave-on products and 1.2% for rinse-off products though it may cause skin irritation in some individuals making patch testing advisable. Uses: Antiinflammatory and antiarthritic agents. Alternative Names: Ivy Leaves extract; Linn extract; English ivy extract; Hedera helix (Ivy) extract; Hedera helix extract; Ivy extract; ivy, hedera helix, extract; Brectanpopavlist; extract of ivy; Hedera Helix, ext. Grades: Crude extract 10:1. CAS | |
| IWP 4 | IWP 4 is a novel and potent inhibitor of Wnt/β-catenin signaling with IC50 value of 25 nM. It blocks palmitylation, subsquent secretion and activity of Wnt. It induces the differentiation of human pluripotent stem cells into cardiomyocytes. It has minimal effect on Notch and Hedgehog signaling pathways. Alternative Names: IWP4; IWP 4; IWP-4; N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide; 2-(3,4,6,7-Tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-ylthio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide. Grades: ≥98% by HPLC. CAS No. 686772-17-8. Molecular formula: C23H20N4O3S3. Mole weight: 496.62. | |
| IWR-1-endo | IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Alternative Names: IWR-1; IWR 1; IWR1; IWR-1-endo. Grades: >98%. CAS No. 1127442-82-3. Molecular formula: C25H19N3O3. Mole weight: 409.44. | |
| IXA4 | IXA4 is a highly selective and non-toxic IRE1/XBP1s activator, which activates the IRE1/XBP1s signaling, regardless of the global activation of the unfolded protein response (UPR) or other stress-responsive signaling pathways, such as heat shock response or oxidative stress response. IXA4 reduces APP secretion by activating IRE1. IXA4 therapy improves systemic glucose metabolism and hepatic insulin action through IRE1-dependent liver transcriptomic remodeling, thereby reducing glucose production and steatosis. IXA4-stimulated IRE1 activation also enhances pancreatic function. Alternative Names: N-(1-(2-(methyl(2-(p-tolyloxy)ethyl)amino)-2-oxoethyl)-1H-pyrazol-4-yl)-3-phenoxypropanamide; 1H-Pyrazole-1-acetamide, N-methyl-N-[2-(4-methylphenoxy)ethyl]-4-[(1-oxo-3-phenoxypropyl)amino]-. Grades: ≥95%. CAS No. 1185329-96-7. Molecular formula: C24H28N4O4. Mole weight: 436.50. | |
| Ixazomib | Ixazomib is a proteasome inhibitor and the biologically active form of MLN9708. Ixazomib exhibits an improved pharmacodynamic profile and antitumor activity compared with bortezomib in both OCI-Ly10 and PHTX22L models. Although both Ixazomib and bortezomib prolonged overall survival, reduced splenomegaly, and attenuated IgG2a levels in the iMyc(Cα)/Bcl-X(L) GEM model, only Ixazomib alleviated osteolytic bone disease in the DP54-Luc model. Alternative Names: MLN2238; MLN-2238; MLN 2238; Ixazomib. Trade name: Ninlaro. (R)-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)boronic acid. Grades: > 95%. CAS No. 1072833-77-2. Molecular formula: C14H19BCl2N2O4. Mole weight: 361.026. | |
| Izonsteride | Izonsteride, a benzothiazolyl derivative, has been found to be a cholestenone 5-alpha reductase inhibitor that was once studied in prostate cancer and probably be useful against androgenic alopecia and benign prostatic hyperplasia. Alternative Names: Izonsteride; LY-320236; LY 320236; LY320236; UNII-A5E8C36F34.; (4AR,10BR)-8-[(4-ETHYL-1,3-BENZOTHIAZOL-2-YL)SULFANYL]-4,10B-DIMETHYL-1H,2H,3H,4H,4AH,5H,6H,10BH-BENZO[F]QUINOLIN-3-ONE. Grades: 98%. CAS No. 176975-26-1. Molecular formula: C24H26N2OS2. Mole weight: 422.62. | |
| Jaboticabin | a minor bioactive depside. Alternative Names: 2-[(3,4-Dihydroxybenzoyl)oxy]-4,6-dihydroxy-benzeneacetic Acid Methyl Ester. Grades: > 95%. CAS No. 911315-93-0. Molecular formula: C16H14O8. Mole weight: 334.29. | |
| Jaguar C 16 | Jaguar C 16. CAS No. 71329-50-5. | |
| JAK3 Inhibitor VI | JAK3 Inhibitor VI. CAS No. 856436-16-3. Molecular formula: C18H13N3O CH3SO3H. Mole weight: 383.40. | |
| JAK-IN-5 | JAK-IN-5 is a JAK inhibitor. (Extracted from patent US20170121327A1, compound example 283). Alternative Names: Phenol, 5-ethyl-2-fluoro-4-[3-[4,5,6,7-tetrahydro-5-(1-methyl-4-piperidinyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-6-yl]-; 5-Ethyl-2-fluoro-4-{3-[5-(1-methyl-4-piperidinyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-6-yl}phenol. Grades: ≥95%. CAS No. 2096999-92-5. Molecular formula: C27H31FN6O. Mole weight: 474.57. | |
| Jalapinolic acid | Jalapinolic acid is a hydroxypalmitic acid. Alternative Names: Hexadecanoic acid, 11-hydroxy-; 11-Hydroxypalmitic acid; Builic acid. Grades: ≥95%. CAS No. 502-75-0. Molecular formula: C16H32O3. Mole weight: 272.42. | |
| Jasmine absolute | Jasmine absolute. Alternative Names: Jasmine, Jasminum grandiflorum, ext.; Jasminum Grandiflorum Extract; Jasmine Absolute; Einecs 283-993-5. Grades: 95%. CAS No. 84776-64-7. | |
| Jasmine oil | Jasmine oil is an essential oil extracted from the flowers of jasmine plant. It has a floral fragrance. Alternative Names: Jasmine concrete. Grades: 95%. CAS No. 8022-96-6. | |
| JASMINONE B | JASMINONE B, a chemical compound exhibiting promising anti-inflammatory and anti-cancer activities, has garnered attention for its capacity to impede inflammatory reactions and suppress tumor proliferation. Its therapeutic potential lies in the realm of inflammation and oncology, positioning it as a viable contender for medicinal interventions. Alternative Names: (E)-2-(Pent-2-enyl)cyclopentan-1-one, 2-(trans-2-Pentenyl)cyclopentanone, Cyclopentanone, 2-(2E)-2-penten-1-yl-, JASMINONE B. Grades: 98.0% (sum of isomers). CAS No. 51608-18-5. Molecular formula: C10H16O. Mole weight: 152.24. | |
| Jasminoside B | Jasminoside B is a monoterpenoid isolated from Gardenia jasminoides Ellis, showing immunosuppressive activity. Grades: 0.98. CAS No. 214125-04-9. Molecular formula: C16H26O8. Mole weight: 346.37. | |
| JC-1 | JC-1 is a cyanine dye used for studying mitochondrial integrity in the context of cellular apoptosis. JC-1 exhibits green fluorescence at low membrane potential and aggregates to exhibit red fluorescence at higher membrane potentials. Alternative Names: 5,6-dichloro-2-[3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)-1-propen-1-yl]-1,3-diethyl-1H-benzimidazolium, monoiodide; CBIC2; NK 1420. Grades: ≥90%. CAS No. 3520-43-2. Molecular formula: C25H27Cl4IN4. Mole weight: 652.2. | |
| JDQ-443 | JDQ-443 is a covalent KRAS G12C inhibitor extracted from patent WO2021120890A1. Alternative Names: JDQ443; JDQ 443; NVP-JDQ443. Grades: 98%. CAS No. 2653994-08-0. Molecular formula: C29H28ClN7O. Mole weight: 526.04. | |
| JH I | JH I. Alternative Names: 12,14-dihomojuvenate; 2,6-tridecadienoicacid,3,11-dimethyl-10,11-epoxy-7-ethyl-,methylester,(e,e; ay22243; c18-juvenilehormone; cecropiajuvenilehormone; juvenilehormonei; methyl12,14-dihomojuvenate; methyl-12-homojuvenate. Grades: 95%. CAS No. 13804-51-8. Molecular formula: C18H30O3. Mole weight: 294.43. | |
| JH-XVI-178 | JH-XVI-178 is a highly potent and selective CDK8/19 inhibitor with low clearance and moderate oral pharmacokinetic properties. Alternative Names: 2,8-Diazaspiro[4.5]decan-1-one, 8-[3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]-; 8-(3-chloro-5-(1-methyl-1H-indazol-5-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one. CAS No. 2648453-53-4. Molecular formula: C22H22ClN7O. Mole weight: 435.91. | |
| JI130 | JI130 is an inhibitor of the cancer-associated transcription factor Hes1 via PHB2 chaperone. JI130 stabilizes the interaction between PHB2 and extranuclear Hes1 and induces G2/M cell cycle arrest. JI130 treatment significantly reduces tumor volume in the murine xenograft model. Alternative Names: 2-Propenamide, 3-(7-methoxy-1H-indol-3-yl)-N-[2-[2-(2-propen-1-yloxy)phenyl]ethyl]-, (2E)-; (2E)-3-(7-Methoxy-1H-indol-3-yl)-N-[2-[2-(2-propen-1-yloxy)phenyl]ethyl]-2-propenamide; (E)-N-(2-(Allyloxy)phenethyl)-3-(7-methoxy-1H-indol-3-yl)acrylamide; JI 130; JI-130. Grades: ≥95%. CAS No. 2234271-86-2. Molecular formula: C23H24N2O3. Mole weight: 376.45. | |
| JIB-04 | JIB-04 is a potent, selective and cell-permeable inhibitor used in compound for cancer research. It targets the histone demethylase KDM5A and effectively suppresses the growth of various cancer cells like triple-negative breast cancer and acute myeloid leukemia. Alternative Names: JIB04; JIB-04; JIB 04; NSC 693627; NSC-693627; NSC 693627. CAS No. 199596-05-9. Molecular formula: C17H13ClN4. Mole weight: 308.769. | |
| JMJD7-IN-1 | JMJD7-IN-1 is a potent JMJD7 inhibitor (IC50 = 6.62 μM) that has good inhibitory activity against cells with high expression of JMJD7. Alternative Names: Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester; 5-nitro-8-quinolyl 2,4-dichlorobenzoate; 2,4-Dichloro-benzoic acid 5-nitro-quinolin-8-yl ester. Grades: ≥98%. CAS No. 311316-96-8. Molecular formula: C16H8Cl2N2O4. Mole weight: 363.15. | |
| JNJ-10397049 | JNJ-10397049 is a selective orexin-2 receptor (OX2) antagonist. pIC50 is 7.4 for chimeric OX2 receptors/ pKB values are 5.9 for OX1 and 8.5 for OX2 receptors respectively. JNJ-10397049 exhibits no significant activity in a panel of over 50 other neurotransmitters and neuropeptide receptors. It achieves high level of OX2 receptor occupancy in the rat brain. Alternative Names: JNJ-10397049; JNJ 10397049; JNJ10397049; 1-(2,4-Dibromophenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-(1,3)dioxan-5-yl)urea. Grades: 98%. CAS No. 708275-58-5. Molecular formula: C19H20Br2N2O3. Mole weight: 484.19. | |
| JNJ-42041935 | JNJ-42041935 is a potent (pK(I) = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes. JNJ-42041935 is a new pharmacological tool, which can investigate PHD inhibition and demonstrate that PHD inhibitors offer great promise for the treatment of inflammation-induced anemia. Alternative Names: JNJ-42041935; JNJ 42041935; JNJ42041935. Grades: 98%. CAS No. 1193383-09-3. Molecular formula: C12H6ClF3N4O3. Mole weight: 346.65. | |
| JNJ-42165279 | JNJ-42165279 is a fatty acid amide hydrolase (FAAH) inhibitor developed by Janssen Pharmaceutica and IC50 value is 70 nM. It is described as a covalently binding but slowly reversible selective inhibitor of FAAH. Phase II human trials for the treatment of anxiety disorders and major depressive disorder is on-going. Uses: Anxiety disorders and major depressive disorder. Alternative Names: N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperazine-1-carboxamide; JNJ-42165279; JNJ 42165279; JNJ42165279. Grades: 98%. CAS No. 1346528-50-4. Molecular formula: C18H17ClF2N4O3. Mole weight: 410.81. | |
| JNJ-54717793 | JNJ-54717793 is a selective antagonist with a preference for Ox1R over Ox2R. Ox1R and Ox2R were indicated to play important roles in the control of sleep-wake, the regulation of food intake, addiction, reward, mood, panic, anxiety and stress. JNJ-54717793 disrupted REM time sleep in Ox2R knockout mice model, and attenuated panic in a CO2-induced model. Uses: Disrupt rem time sleep, attenuate panic. Alternative Names: JNJ 54717793; JNJ54717793. CAS No. 1628843-99-1. Molecular formula: C22H18F4N6O. Mole weight: 458.41. | |
| JNJ 55511118 | JNJ 55511118 has been found to be an AMPA receptor modulator and could probably be used as an anticonvulsant. Alternative Names: JNJ-55511118; JNJ 55511118; JNJ55511118; 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one. Grades: ≥98% by HPLC. CAS No. 2036081-86-2. Molecular formula: C14H8ClF3N2O2. Mole weight: 328.67. | |
| Josiphos SL-J216-2 | Josiphos SL-J216-2 is a chiral phosphine ligand for enantioselective synthesis with high yield and high enantioselective results. Alternative Names: (S)-1-{(RP)-2-[Di(1-naphthyl)phosphino]ferrocenyl}ethyldi-tert-butylphosphine; (2S)-1-[(1S)-1-[Bis(1,1-dimethylethyl)phosphino]ethyl]-2-(di-1-naphthalenylphosphino)ferrocene. Grades: cp95%, ee99%. CAS No. 849924-44-3. Molecular formula: C40H44FeP2. Mole weight: 642.57. | |
| JPH203 | JPH203 is a potent and selective L-type amino acid transporter 1 (LAT1) inhibitor. It inhibits 14C-leucine uptake and cell growth in human colon cancer-derived HT-29 cells in vitro. It also inhibits 14C-leucine uptake in mouse renal proximal tubule cells expressing l-type amino acid transporter 1, and inhibits cell growth. It completely inhibits the proliferation of YD-38 cells in a dose- and time-dependent manner. It suppresses proliferation in cancer cell lines and is used for cancer research. It was developed by J-Pharma and in clinic phase 1 trials. Uses: Jph203 suppresses proliferation in cancer cell lines and is used for cancer research. Alternative Names: KYT-0353;KYT0353;JPH-203; KYT 0353;JPH 203;(S)-2-amino-3-(4-((5-amino-2-phenylbenzo[d]oxazol-7-yl)methoxy)-3,5-dichlorophenyl)propanoic acid. Grades: >98 %. CAS No. 1037592-40-7. Molecular formula: C23H19Cl2N3O. Mole weight: 472.32. | |
| JQKD82 | JQKD82 is a selective and cell-permeable KDM5 inhibitor that increases H3K4me3 and can be used in multiple myeloma studies. Alternative Names: JADA82; PCK82; 4-Pyridinecarboxylic acid, 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-, 2,4-bis(1-methylethoxy)phenyl ester; 2,4-diisopropoxyphenyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate. Grades: ≥95%. CAS No. 2410512-38-6. Molecular formula: C27H40N4O5. Mole weight: 500.63. | |
| Juniper berry oleoresin | Juniper berry oleoresin. Alternative Names: oilofjuniper; oils,juniperuscommunis; JUNIPER BERRIES OIL; Juniperberryoil,Dalmazia; Juniperuscommunisoil; JUNIPERBERRYOIL,2XRECTIFIED; JUNIPERUSSABINAESSENTIALOIL. Grades: 95%. CAS No. 8012-91-7. Molecular formula: CAS: 8012-91-7. | |
| Juvenile hormone II | Juvenile hormone II. Alternative Names: TRANS,TRANS-10,11-EPOXY-3,7,11-TRIMETHYL-2,6-DODECADIENIC ACID METHYL ESTER; JH II; JH-III; JUVENILE HORMONE 11; JUVENILE HORMONE III; MANDUCA HORMONE; [+/-]-CIS-10,11-EPOXY-3,7,11-TRIMETHYL-TRANS,TRANS-2,6-DODECADIENOIC ACID METHYL ESTER; C16-JUVENILE HORMONE. CAS No. 34218-61-6. Molecular formula: C16H26O3. Mole weight: 266.38. | |
| K777 | K-11777 is a potent, irreversible cysteine protease inhibitor. Besides, K11777 is not only a substrate but also a mechanism-based inhibitor of CYP3A4. Alternative Names: 233277-99-1;K777;K-777;APC-3316;K-11777;CRA-3316;SLV213;SLV-213;K1177;K-1177;502960-90-9;CHEMBL91704;4-Methyl-N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide;320A4L58IZ;1-Piperazinecarboxamide, 4-methyl-N-((1S)-2-oxo-2-(((1S)-1-(2-phenylethyl)-3-(phenylsulfonyl)-2-propenyl)amino)-1-(phenylmethyl)ethyl)-;1-Piperazinecarboxamide, 4. Grades: >98%. CAS No. 233277-99-1. Molecular formula: C99H148N24O25S2. Mole weight: 2138.5. | |
| K811 | K811 is a specific inhibitor of ASK1, which can prolong the survival time of the mouse model of amyotrophic lateral sclerosis. Alternative Names: AC-31496. Grades: ≥98% by HPLC. CAS No. 1355228-38-4. Molecular formula: C29H26N4O5. Mole weight: 510.5. | |
| KAAD-Cyclopamine | KAAD-Cyclopamine is a sonic hedgehog antagonist known to target Smoothened. Hedgehog signaling is involved in embryogenesis as well as cancer progression. KAAD-Cyclopamine has been utilized to halt the migration or proliferation of a variety of cancer cells (e.g. esophageal, gastrointestinal, hepatic and pancreatic cancer). Uses: Differentiation. Grades: 0.98. CAS No. 306387-90-6. Molecular formula: C44H63N3O4. Mole weight: 697.99. | |
| KADETHRIN | KADETHRIN. Alternative Names: (5-(phenylmethyl)-3-furanyl)methylester,(1r-(1-alpha,3-alpha(e)))-imethyl; )-cyclopropanecarboxylate; [1r-[1alpha,3alpha(e)]]-[5-(phenylmethyl)-3-furanyl]methyl3-[(dihydro-2-ox; 1r,cis-ru15525; 3-((dihydro-2-oxo-3(2h)-thienylidene)methyl)-2,2-dimethyl-,(5-(p. CAS No. 58769-20-3. Molecular formula: C23H24O4S. Mole weight: 396.5. | |
| Kaempferol-3-O-(6-Malonyl-Glucoside) | Kaempferol-3-O-(6-Malonyl-Glucoside) is an abundant and multifaceted natural compound ubiquitously present in a diverse range of botanical species. This enthralling compound exhibits profound antioxidant prowess, studying the detrimental effects of free radicals and oxidative stress. Moreover, it showcases remarkable anti-inflammatory properties that hold promise for studyting an assortment of ailments, including cancer, cardiovascular afflictions, and neurodegenerative maladies. Alternative Names: 3-[[(2R,3S,4S,5R,6S)-6-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-3-oxopropanoic acid. Grades: > 95%. CAS No. 81149-02-2. Molecular formula: C24H22O14. Mole weight: 534.43. | |
| Kahalalide F | Kahalalide F is one of a family of novel peptides isolated from the Hawaiian mollusk, Elysia rufescens. It is currently in Phase II trials for hepatocarcinoma. Kahalalide F (KF) is a novel antitumor drug of marine origin under clinical investigation. KF showed a potent cytotoxic activity against a panel of human prostate and breast cancer cell lines, with IC50 ranging from 0.07 μm (PC3) to 0.28 μm (DU145, LNCaP, SKBR-3, BT474, MCF7). Importantly, nontumor human cells (MCF10A, HUVEC, HMEC-1, IMR90) were 5-40 times less sensitive to the drug (IC50 = 1.6-3.1 μm). Alternative Names: Kahalalide F; PM-92102; PM 92102; PM92102. CAS No. 149204-42-2. Molecular formula: C75H124N14O16. Mole weight: 1477.90. | |
| Kahweofuran | Kahweofuran. Alternative Names: kahweofuran; TomatoLycopene; Spicery; 2,3-Dihydro-6-methylthieno[2,3-c]furan; 6-Methyl-2,3-dihydrothieno[2,3-c]furan. CAS No. 26693-24-3. Molecular formula: C7H8OS. Mole weight: 140.20. | |
| Kahweol | Kahweol is a natural product isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans. Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis. Alternative Names: 5a,8-Methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol, 3b,4,5,6,7,8,9,10,10a,10b-decahydro-7-hydroxy-10b-methyl-, (3bS,5aS,7R,8R,10aR,10bS)-; (3bS,5aS,7R,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b-Decahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol. Grades: 98%. CAS No. 6894-43-5. Molecular formula: C20H26O3. Mole weight: 314.42. | |
| Kainic acid | Kainic acid is a naturally occurring neuroexcitatory amino acid. It is a selective agonist for a subtype of ainate-class ionotropic glutamate receptor found in seaweed. It increases production of mitochondrial dysfunction, reactive oxygen species and apoptosis in neurons in many regions of the brain. It increases glutamate release and stimulates Na channels, inducing epileptic seizures and neurocytosis (apoptosis). It has been used to study mechanisms of apoptosis and epilepsy. Uses: Excitatory amino acid agonists. Alternative Names: (2S,3S,4S)-3-(carboxymethyl)-4-(prop-1-en-2-yl)pyrrolidine-2-carboxylic acid; 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine; (-)-α-Kainic Acid; Digenic Acid; Digenin; Helminal; L-α-Kainic Acid; α-Kainic Acid. Grades: ≥98% by HPLC. CAS No. 487-79-6. Molecular formula: C10H15NO4. Mole weight: 213.23. | |
| kakkalide | Kakkalide is a flavonoid isolated from Pueraria lobata, showing anti-inflammatory effects and protective effects on ethanol-induced lethality. Alternative Names: Kakkalide; 58274-56-9; 5-hydroxy-6-methoxy-3-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one; SCHEMBL23830145; DTXSID10207003; HY-N4244; AKOS030621547; MS-30682; CS-0032520; E88714; 4H-1-Benzopyran-4-one, 5-hydroxy-6-methoxy-3-(4-methoxyphenyl)-7-((6-O-beta-D-xylopranosyl-beta-D-glucopyranosyl)oxy)-. Grades: 0.98. CAS No. 58274-56-9. Molecular formula: C28H32O15. Mole weight: 608.6. | |
| Kanamycin A sulfate | Kanamycin, an aminoglycoside antibiotic first isolated from the bacterium Streptomyces kanamyceticus, has inhibitory effect on gram-positive and negative bacteria and mycoplasma. It can be used for the prevention and treatment of chicken pullorum, colibacillosis, enteritis and other diseases, and has a significant effect on systemic sepsis, respiratory tract infection, peritonitis caused by drug-resistant bacteria. Alternative Names: D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:1); O-3-Amino-3-deoxy-α-D-glucopyranosyl-(16)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(14)]-2-deoxy-D-streptamine Sulfate; Cantrex; Cristalomicina; Enterokanacin; Kamycin; Kanabristol; Kanamytrex; Kanaqua; Kanasig; Kanatrol; Kanescin; Otokalixin; Resistomycin; Kanamycin, sulfate (1:1) (salt); Kanacedin; Kanachron; Kanamycin A monosulfate; Kanamycin monosulfate; Kanamycin sulfate; Kannasyn; Kano; Kantrex; Kantrexil; Kantrim; Kantrox; Kasmynex; Kenendomycin; Klebcil; Ophtalmokalixan. Grades: 98%. CAS No. 25389-94-0. Molecular formula: C18H38N4O15S. Mole weight: 582.58. | |
| Kanamycin Sulfate | Kanamycin sulfate is an aminoglycoside antibiotic that has inhibitory effects on gram-positive and negative bacteria and mycoplasma. The mechanism of action is to target the 70S ribosomal subunit of the bacteria to inhibit ribosomes. Translocations and causing erroneous codes further interfere with protein synthesis. It can be used for respiratory and urinary tract infections and sepsis caused by sensitive bacteria, and has a certain effect on swine asthma and atrophic rhinitis. Alternative Names: Kanamycin, sulfate (salt). Grades: ≥95%. CAS No. 70560-51-9. | |
| Kaolin | Kaolin is a clay that is essentially kaolinite, a hydrated aluminum silicate. It has a high fusion point and is the most refractory of all clays. In oral medicines, kaolin is used as a diluent in tablet and capsule preparations. It is also used as a suspending vehicle. Therapeutically, kaolin has been used as an oral antidiarrheal agent. Uses: Hair care, soap, body care, face care. Alternative Names: Hydrated aluminum silicate; Bolus alba; ASP; Acidic white clays; Alfaplate; Alpha-Print; Alphacoat; Alphacote; Alphagloss; Alphalux 91; Altowhite; Apsilex; Argiflex; Argil; Argilla; Asphaltex; Astra-Cote; Astra-Glaze; Astra-Plate; Astracote 90; Astrasheen; BSK-H; Barden clay; Barrisurf HX; Barrisurf LX; CMP. CAS No. 1332-58-7. Molecular formula: Al2H4O9Si2. Mole weight: 258.16. | |
| kappa-Carrageenan | Kappa-Carrageenan is a gelling sulfated galactan extracted from red seaweed (typically Gigartina stellata and Chondrus Crispus). All carrageenan structures consist of (1-3) linked α-d-galactose and (1-4) linked β-d-galactose strictly alternating concealed repeat units. The α-linked galactose is present as a 3,6-dehydrated unit, and the β-linked sugars as a 3-sulfate. Uses: ·adhesives, thickeners, emulsifiers and stabilizers in the food industry ·culture medium, medicament, anticoagulant, hypolipidemic agent and laxative in the field of medicine ·used as an antistatic agent for photosensitive emulsions and photosensitive emulsion layers ·embedding material for immobilized enzyme carrier and bacteria ·for leather industry, ceramic industry, textile industry and paper industry. Alternative Names: κ-Carrageenan; Carrageenan CS 562; Carrageenan CSK 1; Carrageenan CSK 2; Carrageenan J; Danagel CCX; Danagel PF 8263; Danagel RC; Deltagel C 80; Gelimar; Genugel CHP 2F; Genugel SWG-J; Genugel WG; Genugel WG 108; Genugel WG 115; Genugel WR 78; Genuvisco SWG-J; Genuvisco X 0909; Inagel E 150; Inagel E 25; Satiagel BWJ 40; Satiagel CG30; Satiagel GS 350; Satiagel ME 5; Sherex 6. CAS No. 11114-20-8. Molecular formula: (C12H17O12S)n. | |
| Karanjin | Karanjin is a paramount compound coveted from the seeds of the exalted Pongamia tree. Esteemed in the research of natural compound for its unparalleled potential in studying the pervasive threat of cancer, Karanjin has unveiled encouraging outcomes in impeding the expansion and replication of assorted cancerous cells. Uses: Anti-tb. Alternative Names: 3-METHOXY-2-PHENYL-4H-FURO[2,3-H]-1-BENZOPYRAN-4-ONE; KARANJIN; karanjin from pongamia glabra oil; 2-Phenyl-3-methoxy-4H-furo[2,3-h]-1-benzopyran-4-one; Kranjin; 3-methoxy-2-phenyl-furo[2,3-h]chromen-4-one; 3-methoxy-2-phenylfuro[2,3-h]chromen-4-one; NSC 335755. Grades: >98%. CAS No. 521-88-0. Molecular formula: C18H12O4. Mole weight: 292.29. | |
| Kartogenin | Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ. Alternative Names: KGN; 2-([1,1'-Biphenyl]-4-ylcarbamoyl)benzoic acid; 2-[(4-phenylphenyl)carbamoyl]benzoic acid. Grades: >98%. CAS No. 4727-31-5. Molecular formula: C20H15NO3. Mole weight: 317.344. | |
| Kathon CG | Kathon CG. Alternative Names: ISOTHIAZOLINONE (MIT, CMIT). Grades: 95%. CAS No. 96118-96-6. | |
| Kauri Gum Solution | Kauri Gum Solution. CAS No. 77465-88-4. | |
| KB02-JQ1 | KB02-JQ1 is a highly selective and PROTAC-based BRD4 degrader (molecular glue), but does not degrade BRD2 or BRD3. JQ1 binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-JQ1. It promotes the degradation of BRD4 by covalently modifying DCAF16 (E3 ligase), and can improve the durability of protein degradation in biological systems. Alternative Names: 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, N-[2-[2-[2-[[2-[[1-(2-chloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl]oxy]acetyl]amino]ethoxy]ethoxy]ethyl]-4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S)-; 2-{[1-(Chloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl]oxy}-N-(2-{2-[2-({[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetyl}amino)ethoxy]ethoxy}ethyl)acetamide. Grades: ≥95%. CAS No. 2384184-44-3. Molecular formula: C38H43Cl2N7O6S. Mole weight: 796.76. | |
| k-Carratriose disulfate disodium salt | k-Carratriose disulfate disodium salt is an invaluable biomedical product, aiding in studying intricate inflammatory maladies like rheumatoid arthritis. Alternative Names: k-Carratriose 14,34-disulfate disodium salt. Grades: ≥98%. Molecular formula: C18H28O21S2Na2. Mole weight: 690.51. | |
| KCNQ2/3 activator-1 | KCNQ2/3 activator-1 is a Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator. KCNQ2/3 activator-1 has the potential in relieving pain (the main problem from medical treatment) (extracted from patent WO2021113757A1, compound A). Alternative Names: Encukalner. Grades: 99%. CAS No. 1009344-33-5. Molecular formula: C23H29FN2O. Mole weight: 368.49. | |
| Kdo2-Lipid A (KLA) | Kdo2-Lipid A (KLA) is a potent immunostimulatory compound used in biomedical field. It activates immune cells via Toll-like receptor 4 (TLR4), triggering cytokine production and enhancing immune responses. This product aids in the study of immune regulation and the development of vaccines and therapeutics targeting infectious diseases, cancer and inflammation. Alternative Names: Di[3-deoxy-D-manno-octulosonyl]-lipid A (ammonium salt). Grades: >95%. CAS No. 1246298-62-3. Molecular formula: C110H202N2O39P2.4NH3. Mole weight: 2306.8. | |
| Kenpaullone | Kenpaullone is a potent inhibitor of CDK1 / cyclin B (IC50 = 400 nM), CDK2 / cyclin A (IC50 = 680 nM), CDK2 / cyclin E (IC50 = 7.5 uM) and CDK5/p25 (IC50 = 850 nM). Kenpaullone inhibits CDK2 / cyclin A, CDK2 / cyclin E and CDK5 / cyclin/p35 (IC50 values are 0.68, 7.5 and 0.85 μM respectively). Uses: Reprogramming. Alternative Names: NSC664704; NSC-664704; NSC 664704; 9-Bromopaullone; 1-azakenpaullone; Kenpaullone. Grades: 98%. CAS No. 142273-20-9. Molecular formula: C16H11BrN2O. Mole weight: 327.18. | |
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