MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| GPAT-IN-1 | GPAT-IN-1 is a glycerol-3-phosphate acyltransferase (GPAT) inhibitor with an IC50 value of 8.9 μM. GPAT-IN-1 can be used for the research of obesity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1204347-51-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-153628. |  |
| GPhos Pd G6 | GPhos Pd G6 (GPhos Pd G6 TES) is a palladium catalyst. GPhos Pd G6 catalyzes the Buchwald-Hartwig amination reaction and promotes C-N bond formation between aryl chlorides and amines. GPhos Pd G6 is a pharmaceutical intermediate used for the synthesis of various active compounds[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GPhos Pd G6 TES. CAS No. 2489525-81-5. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-W590989. | |
| GPNA hydrochloride | GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 67953-08-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W011391. | |
| GPR120 Agonist 3 | GPR120 Agonist 3 is a selective Gpr120 agonist with a logEC50 of 7.62. Uses: Scientific research. Category: Signaling pathways. CAS No. 1599477-75-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101492. | |
| GPR132 antagonist 1 | GPR132 antagonist 1 (GPR132-B-160, Compound 25) is a GPR132 antagonist with an EC50 value of 0.075 μM. GPR132 antagonist 1 has promote insulin secretion activity with an EC50 value of 0.7 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 898211-21-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-157189. | |
| GPR139 agonist-2 | GPR139 agonist-2 (compound 20a) is a potent GPR139 agonist with an EC50 of 24.7 nM. GPR139 agonist-2 rescues the social interaction deficits and alleviates cognitive deficits in murine schizophrenia models. GPR139 agonist-2 has the potential for antischizophrenia drug research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2983118-29-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-149651. | |
| GPR15 antagonist-1 | GPR15 antagonist-1 (Compound 5) is a GPR15 antagonist. G protein-coupled receptor 15 (GPR15) is an extensively studied GPCRs involving HIV infection, colonic inflammation, and smoking-related diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 252280-67-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-177116. | |
| GPR183 antagonist-3 | GPR183 antagonist-3 (compound 33) is an oral active GPR183 antagonist with the IC50 of 8.7 μM. GPR183 antagonist-3 displays strong in vitro antimigration and anti-inflammatory activity in monocytes, and improves the pathological symptoms of DSS-induced experimental colitis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3054870-33-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157939. | |
| GPR30 agonist-1 | GPR30 agonist-1 is a G protein-coupled receptor 30 (GPR30) agonist. GPR30 agonist-1 exerts vasorelaxant effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 415919-74-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-138686. | |
| GPR34 receptor antagonist 2 | GPR34 receptor antagonist 2 (Compound D2) is a GPR34 receptor antagonist. GPR34 receptor antagonist 2 can be used for immune diseases, inflammatory diseases research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 907952-06-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138501. | |
| GPR34 receptor antagonist 3 | GPR34 receptor antagonist 3 (Compound 5e) is a class of GRP34 antagonists, IC50 is 0.680 μM. GPR34 receptor antagonist 3 inhibited ERK1/2 phosphorylation induced by lysophosphatidylserine in a dose-dependent way without obvious cytotoxicity. GPR34 receptor antagonist 3 shows antisensory activity in mouse neuropathic pain model [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3049949-94-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155417. | |
| GPR35 agonist 1 | GPR35 agonist 1 (compound 50) is a potent and specific G protein-coupled receptor-35 (GPR35)/CXCR8 agonist with an EC50 of 5.8 nM, displays good agentgability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2079880-92-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101033. | |
| GPR35 agonist 4 | GPR35 agonist 4 (compound 10) is a potent GPR35 agonist with an pEC50 of 5.86. GPR35 agonist 4 shows high potency human and rat GPR35. Mutation of arginine 3.36 eliminates agonist function of GPR35 agonist 4[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 871085-49-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-107539. | |
| GPR3 agonist-2 | GPR3 agonist-2(compound 32) is a potent full agonist of G protein-coupled receptor 3, with the IC50of 260 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1983120-51-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155318A. | |
| GPR40 agonist 4 | GPR40 agonist 4 is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54. Uses: Scientific research. Category: Signaling pathways. CAS No. 2102196-57-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103083. | |
| GPR41 agonist-1 | GPR41 agonist-1 (compound 9) is a potent GPR41 agonist. GPR41 agonist-1 can be used for researching insulin-related disorders[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 506417-09-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147394. | |
| GPR4 antagonist 1 | GPR4 antagonist 1 is a GPR4 antagonist, with an IC50 of 189 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1197879-16-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101536. | |
| GPR52 agonist-1 | GPR52 agonist-1 is a potent, orally active and blood-brain barrier (BBB) penetrant GPR52 agonist with an pEC50 value of 7.53. GPR52 agonist-1 affects cAMP accumulation through direct interaction with GPR52. GPR52 agonist-1 can significantly suppress Methamphetamine-induced hyperactivity in mice. Antipsychotic activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1207965-40-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-147395. | |
| GPR52 antagonist-1 | GPR52 antagonist-1 (Compound 43) is a GPR52 antagonist with an IC50 of 0.63 μM. GPR52 antagonist-1 reduces mHTT (mutant huntingtin protein) levels by targeting GPR52 and promotes survival of mouse primary striatal neurons[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1239987-91-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145468. | |
| GPR81 agonist 1 | GPR81 agonist 1 is a potent and highly selective GPR81 agonist, with EC50s of 58 nM and 50 nM for human and mouse GPR81, respectively. GPR81 agonist 1 inhibits lipolysis in differentiated 3T3-L1 adipocytes. GPR81 agonist 1 suppresses lipolysis in mice without cutaneous flushing. GPR81 agonist 1 displays remarkable selectivity for GPR81 over GPR109a[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1620992-67-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-135982. | |
| GPRP | GPRP (Gly-Pro-Arg-Pro; Pefa 6003) is a fibrin polymerization inhibitor that inhibits the interaction between fibrinogen and the platelet membrane glycoprotein ?b/IIIa complex (glycoprotein IIb/IIIa receptor). GPRP increases the level of free thrombin in activated platelet-rich plasma by reducing the adsorption of thrombin onto fibrin. GPRP inhibits platelet aggregation and prolongs the thrombin-initiated clotting time in plasma. GPRP is applicable for research related to thrombosis and thrombotic diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gly-Pro-Arg-Pro; Pefa 6003. CAS No. 67869-62-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0074. | |
| GPRP acetate | GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gly-Pro-Arg-Pro acetate; Pefa 6003 acetate. CAS No. 157009-81-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0074A. | |
| GPS1573 | GPS1573 is a noncompetitive antagonist of melanocortin type 2 receptor (MC2R) that dose-dependently antagonizes ACTH-stimulated MC2R activity (IC50=66 nM). GPS1573 can be used in the study of Cushing's disease due to its highly selective antagonism of MC2R[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2445822-54-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P10571. | |
| GPV0057 | GPV0057 (Compound 5d) is a selective and potent P-glycoprotein (P-gp) inhibitor. GPV0057 is also a selective potassium channel Kir2.1 activator. GPV0057 competitively binds to the substrate-binding site of P-gp, inhibiting ATP-dependent drug efflux to reverse multidrug resistance in tumor cells. GPV0057 can also stabilizes the open state of Kir2.1 and promotes potassium ion influx. GPV0057 is promising for research of tumors with high P-gp expression, Kir2.1-deficient diseases such as heart failure and Andersen-Tawil Syndrome[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 86383-89-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173162. | |
| GPX4 activator 1 | GPX4 activator 1 (Compound A9) is a allosteric activator of GPX4 (Kd = 5.86 μM, EC50 = 19.19 μM). GPX4 activator 1 can selectively act on ferroptosis and prevent the accumulation of intracellular lipid peroxides caused by ferroptosis inducers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1030098-18-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161928. | |
| GPX4 activator 2 | GPX4 activator 2 is a GPX4 activator with a Ka value of 0.426 μM for human GPX4. GPX4 activator 2 reduces lipid hydroperoxide levels, prevents lipid peroxide accumulation, and inhibits ferroptosis. GPX4 activator 2 rescues cell death induced by Erastin (HY-15763). GPX4 activator 2 exerts cardioprotective effects in a mouse model of doxorubicin (HY-15142A)-induced myocardial injury[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 950365-31-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161929. | |
| GPX4-IN-19 | GPX4-IN-19 is an effective GPX4 inhibitor (IC50 = 0.311 μM), covalently binds to the Sec 46 site of GPX4. GPX4-IN-19 shows strong anti-proliferative activity with high ferroptosis selectivity. GPX4-IN-19 causes intracellular Fe2+ accumulation, leading to increased levels of lipid peroxides (LPOs) and reactive oxygen species (ROS), which induces ferroptosis and subsequently results in DNA damage. GPX4-IN-19 can be used for the study of Triple-Negative Breast Cancer (TNBC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3102894-57-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-178364. | |
| GPX4-IN-3 | GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2761004-85-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141809. | |
| GPX4-IN-4 | GPX4-IN-4 (Compound 24) is a potent GPX4 inhibitor. GPX4-IN-4 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2920221-53-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149923. | |
| GPX4-IN-5 | GPX4-IN-5 is a covalent inhibitor of GPX4 (IC50: 0.12 μM). GPX4-IN-5 can induce ferroptosis and has anti-tumor effects. GPX4-IN-5 can be used in the study of triple-negative breast cancer (TNBC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2922824-09-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-155663. | |
| GR103545 fumarate | GR103545 is a potent and selective agonist of the κ-opioid receptor (κ-OR). 11GR103545 is a radiotracer for imaging κ-OR in vivo[1] | |
| GR 113808 | GR 113808 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8). GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 144625-51-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103152. | |
| GR127935 hydrochloride | GR127935 hydrochloride is a potent and orally active 5-HT1D and 5-HT1B receptor antagonist with pKis of 8.5 for both isoforms. GR127935 hydrochloride has 100-fold selectivity for 5-HT1B/1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors. GR127935 hydrochloride can be used in neurological disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 148642-42-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-100794. | |
| GR148672X | GR148672X is an inhibitor of carboxylesterase 1 (CES1) and hepatic microsomal triglyceride hydrolase (TGH). GR148672X blocks the catalytic activity of CES1, impairs the functions of triglyceride and cholesteryl ester lipase, reduces triglyceride mobilization and secretion, and decreases apolipoprotein B-100 secretion in primary rat hepatocytes. Under low-glucose conditions, GR148672X inhibits the survival of colorectal cancer cells by reducing free fatty acid availability, inducing toxic triglyceride accumulation, ROS production, mitochondrial damage, ferroptosis and apoptosis. GR148672X can be used in studies related to colorectal cancer and atherosclerosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 263890-70-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110390. | |
| GR24 | (Rac)-GR24 (Strigolactone GR24) is a plant hormone analog. (Rac)-GR24 can mimic the natural germination stimulus of parasitic plant seeds, promoting seed germination in the absence of host plants, thereby reducing the number of parasitic seeds in the soil. (Rac)-GR24 can be used in agricultural research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Strigolactone GR24. CAS No. 76974-79-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129038. | |
| GR-73632 | GR-73632 is a tachykinin NK1 receptor agonist. GR-73632 activates spinal NK1 receptors to induce scratching, biting and licking behaviors. GR-73632 activates peripheral NK1 receptors to trigger lacrimation in guinea pigs, and activates central NK1 receptors to induce repetitive hind paw tapping behavior in gerbils. GR-73632 is applicable to research related to pruritus[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 133156-06-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1192. | |
| GR 89696 | GR 89696 is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 126766-32-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg. Product ID: HY-107747. | |
| Gracillin | Gracillin is a steroidal saponin that can be extracted from the roots of the plant and has anti-tumor properties. Gracillin can induce cancer cell apoptosis and autophagy[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 19083-00-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0706. | |
| Gramicidin | Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations. Uses: Scientific research. Category: Signaling pathways. CAS No. 1405-97-6. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-P0163. | |
| Gramicidin S | Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC50s of 41 μM, 24 μM, and 3 μM for Na+/K+-ATPase, tobacco leaf plasma membrane Mg2+/K+-ATPase, and rat heart plasma membrane Ca2+-ATPase, respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Gramicidin soviet. CAS No. 113-73-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P5712. | |
| Gramine | Gramine (Donaxine) is an alkaloid, acts as an active adiponectin receptor (AdipoR) agonist, with IC50s of 3.2 and 4.2 μM for AdipoR2 and AdipoR1, respectively[1]. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist[2]. Gramine (Donaxine) has anti-tumor, anti-viral and anti-inflammatory properties[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Donaxine. CAS No. 87-52-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg. Product ID: HY-N0166. | |
| Granisetron | Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BRL 43694. CAS No. 109889-09-0. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-B0071. | |
| Grape seed extract | Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 84929-27-1. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-N7072. | |
| Graphitic carbon nitride | Graphitic carbon nitride is a metal-free photocatalyst with a semiconductor absorption wavelength of 460 nm. Graphitic carbon nitride can be applied to photocatalytic water splitting, degradation of organic pollutants, and carbon dioxide reduction[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 143334-20-7. Pack Sizes: 250 mg; 500 mg; 1 g. Product ID: HY-W540000. | |
| Grapiprant | Grapiprant (CJ-023423) is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor with IC50 value of 35 nM and Ki value of 24 nM. Grapiprant has the potential for osteoarthritic pain and inflammation treatment[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CJ-023423; RQ-00000007; AAT-007. CAS No. 415903-37-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16781. | |
| Grassofermata | Grassofermata is a dual Arf1/Arf6 activation inhibitor. ADP ribosylation factors (Arfs) are members of the Arf family of GTP-binding proteins of the Ras superfamily. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NAV-2729. CAS No. 419547-11-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112473. | |
| Graveoline | Graveoline (Rutamine) is an orally active alkaloid with various activities such as antifungal, antiparasitic, anti-inflammatory, and antitumor effects. Graveoline can induce tumor cell apoptosis and autophagy through a reactive oxygen species-mediated pathway. Graveoline has an MIC of 500 μg/mL for Candida albicans. Graveoline can be used in the research of various diseases such as tumors and liver injury[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Rutamine. CAS No. 485-61-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 1 g. Product ID: HY-12538. | |
| Grazoprevir | Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively[1][2]. Grazoprevir inhibits SARS-CoV-2 3CLpro activity[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-5172. CAS No. 1350514-68-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15298. | |
| Grazoprevir hydrate | Grazoprevir hydrate (MK-5172 hydrate) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively[1][2]. Grazoprevir hydrate inhibits SARS-CoV-2 3CLpro activity[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-5172 hydrate. CAS No. 1350462-55-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15298B. | |
| Grazoprevir potassium salt | Grazoprevir potassium salt (MK-5172 potassium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively[1][2]. Grazoprevir potassium salt inhibits SARS-CoV-2 3CLpro activity[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-5172 potassium salt. CAS No. 1206524-86-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15298A. | |
| GREDVGC | GREDVGC is a peptide. GREDVGC can mimic VCAM-1 for binding to integrin α4β1. GREDVGC can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1810716-06-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P11445. | |
| Green CMFDA | Green CMFDA is a cell-permeable fluorescent probe with Em of 514 nm and Ex of 485 nm and can be used as a cell tracer. Green CMFDA can be cleaved by non-specific esterases common in living cells, producing a fluorescent compound, fluorescein, visible using a fluorescent microscope[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CMFDA. CAS No. 136832-63-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-126561. | |
| Green DND-26 | Green DND-26 is a green fluorescently labeled lysosomal probe with a maximum excitation/emission wavelength of 504/511 nm. The structure is composed of a fluorescein group and linked weak bases, which can freely cross the cell membrane and generally gather on spherical organelles. Green DND-26 is suitable for observing the internal biosynthesis and related pathogenesis of lysosomes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 220524-71-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1296. | |
| Gremubamab | Gremubamab (MEDI3902) is a humanized IgG1 kappa anti-PcrV/Psl monoclonal antibody. Gremubamab binds to the PA PcrV protein and Psl exopolysaccharide. Gremubamab has the potential for the research of pseudomonas aeruginosa infections[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MEDI3902. CAS No. 1800381-36-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99649. | |
| Gresonitamab | Gresonitamab (AMG 910) is a half-life extended (HLE) bispecific T-cell engager (BiTE) antibody targets CD3-positive T cells and CLDN18.2-expressing tumor cells. Gresonitamab can be used for the research of adenocarcinoma[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG 910; Anti-Human CD3xClaudin18 2. CAS No. 2413817-97-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99350. | |
| GRF (1-29) amide (rat) | GRF (1-29) amide (rat) is a synthetic peptide which can stimulate the growth hormone (GH) secretion. Uses: Scientific research. Category: Signaling pathways. Alternative Names: rGHRH(1-29)NH2. CAS No. 91826-20-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1155. | |
| GRGDSP | GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 91037-75-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0290. | |
| GRGDSPK | GRGDSPK (EMD 56574) is a peptide incluing Arg-Gly-Asp (RGD). GRGDSPK (EMD 56574) is an competitive and reversible inhibitory peptide for inhibiting integrin-fibronectin binding. GRGDSPK is used to study the role of integrins in bone formation and resorption[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EMD 56574. CAS No. 111119-28-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P0322. | |
| GRGESP | GRGESP is a collagen gel contraction inhibitor. GRGESP inhibits the spreading of human fibroblasts inside collagen gels and markedly decreased gel contraction. GRGDSP can be used for the research of connective tissue morphogenesis[1]. Uses: Scientific research. Category: Peptides. CAS No. 99896-88-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P3524. | |
| Griseofulvin | Griseofulvin is an orally active antifungal antibiotic with antitumor activity. Griseofulvin induces apoptosis and G2/M cell cycle arrest in cancer cells. Griseofulvin also has cardiovascular modulatory activity, reducing angina pectoris, relieving hand artery spasm associated with onychomycosis, and peripheral vascular diseases such as shoulder-hand syndrome[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 126-07-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g; 25 g. Product ID: HY-17583. | |
| Grisnilimab | Grisnilimab (WT1) is an IgG2a monoclonal antibody targeting CD7. Grisnilimab only binds to lymphoid tissues and T lymphocytes, with no off-target binding to normal tissues. Grisnilimab can be used to synthesize the immunotoxin WT1-SMPT-dgRTA, which exerts cytotoxic effects on T-lymphoblastic leukemia cells. Grisnilimab is applicable to relevant research on leukemia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WT1. CAS No. 2367001-70-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99650. | |
| GRK2 degrader-1 | GRK2 degrader-1 (compound 1) is a potent and orally active GRK2 degrader. GRK2 degrader-1 degrades GRK2 via the ubiquitin-proteasome pathway. GRK2 degrader-1 inhibits right ventricular remodeling and elevation of pulmonary artery pressure in a pulmonary artery hypertension (PAH) mouse model. GRK2 degrader-1 can be used for PAH research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3052947-04-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-177948. | |
| GRK2 Inhibitor 1 | GRK2 Inhibitor 1 (methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate) is a dual GRK2/β-ARK1 inhibitor that induces dopamine (DA) inhibition reversal (DIR). GRK2 Inhibitor 1 can also block serotonin-induced or neurotensin-induced DIR reversal. Note: DIR refers to the phenomenon in which neurons in addiction-related brain pathways become less sensitive to DA inhibition when exposed to moderate concentrations of DA for a long time[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 24269-96-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123538. | |
| GRK2 Inhibitor 2 | GRK2 Inhibitor 2 is an orally active and selective G protein-coupled receptor kinase 2 (GRK) inhibitor with an IC50 of 19 nM. GRK2 Inhibitor 2 also inhibits Aurora-A with an IC50 of 137 nM. GRK2 Inhibitor 2 can be used in the study of congestive heart failure (HF)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2592436-21-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-156863. | |
| GRK5-IN-2 | GRK5-IN-2 (compound 707), a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor with an IC50 of 49.7 μM. GRK5-IN-2 regulates the expression and/or release of insulin and is useful for the metabolic disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1642839-27-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136561. | |
| GRK6-IN-1 | GRK6-IN-1 (Compound 18) is the inhibitor for G protein-coupled receptorkinase 6 (GRK6) with an IC50 of 3.8-8 nM. GRK6-IN-1 also inhibits GRK7, GRK5, GRK4 and GRK1 with IC50s of 6.4, 12, 22 and 52 nM, respectively. GRK6-IN-1 has the potential for the research of multiple myeloma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2677786-61-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142812. | |
| GRL0617 | GRL0617 is a selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro), with an IC50 of 0.6 μM and a Ki value of 0.49 μM. GRL0617 also inhibits SARS-CoV with an EC50 of 14.5 μM. GRL0617 can be used for the research of severe acute respiratory syndrome[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1093070-16-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117043. | |
| Grp94 Inhibitor-1 | Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor with an IC50 value of 2 nM, and over 1000-fold selectivity to Grp94 against Hsp90α[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2234897-35-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112910. | |
| Gruticibart | Gruticibart is an anti-F11 human IgG4 κ monoclonal antibody[1]. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003). Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: AB023; Xisomab 3G3; MAB 14E11. CAS No. 2704554-77-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P990743. | |
| GS143 | GS143 is a selec-tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup-presses NF-κB acti-va-tion and tran-scrip-tion of tar-get genes and does not inhibit proteasome activity. GS143 has anti-asthma effect[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 916232-21-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110261. | |
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