MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Guadecitabine sodium | Guadecitabine sodium (SGI-110 sodium) is a second-generation DNA methyltransferases (DNMT) inhibitor for research of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SGI-110 sodium; S-110 sodium. CAS No. 929904-85-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15229. |  |
| Guaiacol | Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Methoxyphenol. CAS No. 90-05-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-N1380. | |
| Guaiacol-d3 | Guaiacol-d3 is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Guaiacol has an anti-inflammatory activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Methoxyphenol-d3. CAS No. 74495-69-5. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N1380S1. | |
| Guaiacylglycerol-beta-guaiacyl ether | Guaiacylglycerol-beta-guaiacyl ether is a phenolic β-O-4 type lignin model compound that mimics the most common β-O-4 aryl ether linkages in plant lignin. Guaiacylglycerol-beta-guaiacyl ether can be degraded by Bacillus amyloliquefaciens CotA. Guaiacylglycerol-beta-guaiacyl ether is a commonly used model compound for studying the β-O-4 inter-unit linkage, the most abundant substructure in lignin, and can be applied to investigate the reaction pathway of vanillin preparation via alkaline nitrobenzene oxidation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7382-59-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W114954. | |
| Guaiol | Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC50 of 0.01 μg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions[1][2][3][4] | |
| Guanabenz | Guanabenz is an orally active α-2-adrenoceptor agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5051-62-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12724. | |
| Guanfacine | Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 29110-47-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17416A. | |
| Guanfacine hydrochloride | Guanfacine hydrochloride is an orally active and blood-brain barrier permeability noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 29110-48-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17416. | |
| Guanidine hydrochloride | Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Guanidinium chloride; Aminoformamidine hydrochloride. CAS No. 50-01-1. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 50 g; 100 g; 500 g. Product ID: HY-B0178A. | |
| Guanidine thiocyanate | Guanidine thiocyanate is a strong protein denaturant and potent inhibitor of nucleases. Guanidinium thiocyanate is a nucleic acid protector in the extraction of DNA and RNA from cells. Guanidine thiocyanate is a common component of buffers used for nucleic acid extraction[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 593-84-0. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 50 g; 100 g; 500 g. Product ID: HY-D0841. | |
| Guanidinoethyl sulfonate | Guanidinoethyl sulfonate (Taurocyamine) is an orally available, blood-brain permeable competitive inhibitor of taurine transporters and a competitive antagonist of glycine receptors (GlyR) (IC50=565 μM). Guanidinoethyl sulfonate has both weak agonist and antagonist effects on GABAA receptors. Guanidinoethyl sulfonate inhibits taurine transmembrane transport and competitively binds to the GlyR ligand binding domain, thereby blocking glycine-mediated chloride influx, and may regulate brain pH to exert neuroprotective effects. Guanidinoethyl sulfonate can be used for neuroprotection studies of ischemic brain injury[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Taurocyamine. CAS No. 543-18-0. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-113329. | |
| Guanidinosuccinic acid | Guanidinosuccinic acid is a nitrogenous metabolite. Uses: Scientific research. Category: Signaling pathways. CAS No. 6133-30-8. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113373. | |
| Guanine | Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 73-40-5. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g; 50 g; 100 g. Product ID: HY-Y1055. | |
| Guanine-13C | Guanine-13C is the 13C labeled Guanine (HY-Y1055)[1]. Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 201489-20-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-Y1055S. | |
| Guanine-13C,15N2 | Guanine-13C,15N2 is the 13C and 15N labeled Guanine (HY-Y1055)[1]. Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 202407-12-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-Y1055S1. | |
| Guanine hydrochloride | Guanine hydrochloride is one of the fundamental components of nucleic acids (DNA and RNA). Guanine hydrochloride is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine hydrochloride has the potential to serve as a large-capacity N pool. Guanine hydrochloride has cytotoxic, antinociceptive and neuroprotective effects[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 635-39-2. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-Y1055A. | |
| Guanoclor | Guanoclor is an antihypertensive compound. Guanoclor is an adrenergic neurone-blocking agent, which also interferes with noradrenaline synthesis by inhibition of the enzyme dopamine beta-hydroxylase[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Vatensol. CAS No. 5001-32-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100796. | |
| Guanosine | Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DL-Guanosine; Vernine. CAS No. 118-00-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g. Product ID: HY-N0097. | |
| Guanosine-13C10,15N5 | Guanosine-13C10,15N5 is the 13C and 15N labeled Guanosine (HY-N0097). Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DL-Guanosine-13C10,15N5; Vernine-13C10,15N5. CAS No. 202406-81-3. Pack Sizes: 1 mg. Product ID: HY-N0097S6. | |
| Guanosine-15N5 | Guanosine-15N5 is the 15N labeled Guanosine[1]. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DL-Guanosine-15N5; Vernine-15N5. CAS No. 204523-20-6. Pack Sizes: 1 mg. Product ID: HY-N0097S3. | |
| Guanosine 5'-diphosphate disodium salt | Guanosine 5'-diphosphate (GDP) disodium salt, a purine nucleoside diphosphate, is interconverted to guanosine by the action of exonucleotidase and phosphorylation of nucleoside to guanine. Guanosine 5'-diphosphate disodium salt activates adenosine 5'-triphosphate-sensitive K+ channel and is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). Guanosine 5'-diphosphate disodium salt is a potential iron mobilizer, which prevents the Hepcidin (HY-P70400)-ferroportin interaction and modulates the interleukin-6 (IL-6)/stat-3 pathway. Elevated levels of guanosine 5-diphosphate are associated with the pathogenesis of neurological diseases. Guanosine 5'-diphosphate disodium salt is promising for the research of inflammation, such as anemia of inflammation (AI)[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDP disodium salt. CAS No. 7415-69-2. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113066A. | |
| Guanosine 5'-diphosphate sodium, 96% (HPLC) | Guanosine 5'-diphosphate (GDP) sodium, 96% (HPLC) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K+ channel. Guanosine 5'-diphosphate sodium, 96% (HPLC) is an iron mobilizer, which forms a complex with hepcidin to inhibit the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/stat-3 pathway. Guanosine 5'-diphosphate sodium, 96% (HPLC) ameliorates the Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4. Guanosine 5'-diphosphate sodium, 96% (HPLC) can be used in the research of AI[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDP sodium, Type I, 96% (HPLC). CAS No. 43139-22-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-113066C. | |
| Guanosine-5'-triphosphate disodium salt | Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5'-GTP disodium salt. CAS No. 56001-37-7. Pack Sizes: 250 mg (100 mM * 4.41 mL in Water); 500 mg (100 mM * 8.82 mL in Water); 1 g (100 mM * 17.63 mL in Water). Product ID: HY-W010737. | |
| Guanosine 5'-triphosphate trisodium | Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate trisodium salt holds promise for research in biosynthesis and skeletal muscle regeneration[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5'-GTP trisodium. CAS No. 36051-31-7. Pack Sizes: 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-12695. | |
| Guanosine 5'-triphosphate trisodium salt hydrate | Guanosine 5'-triphosphate (5'-GTP) trisodium salt hydrate is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt hydrate can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt hydrate holds promise for research in biosynthesis and skeletal muscle regeneration[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5'-GTP trisodium salt hydrate. CAS No. 207300-85-4. Pack Sizes: 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-12695B. | |
| Guanosine (Standard) | Guanosine (Standard) is the analytical standard of Guanosine. This product is intended for research and analytical applications. Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.In Vitro: Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). These forms play important roles in various biochemical processes such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction (cGMP). Uses: Scientific research. Category: Signaling pathways. Alternative Names: DL-Guanosine (Standard); Vernine (Standard). CAS No. 118-00-3. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-N0097R. | |
| Guanylyl Imidodiphosphate trisodium | Guanylyl Imidodiphosphate (Guanosine 5'-[β,γ-imido]triphosphate) trisodium is a non-hydrolysable GTP analogue, an activator of ADP-ribosylation factor (ARF) and a potent stimulator of adenylate cyclase. Imidodiphosphate trisodium can be used in protein synthesis studies[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Guanosine 5'-[β,γ-imido]triphosphate trisodium. CAS No. 148892-91-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100767. | |
| Guar gum | Guar gum is an orally active nonionic galactomannan polysaccharide. It is present in the endosperm of Cyamopsis tetragonolobus seeds. Guar gum reduces cholesterol levels, regulates body weight, and acts as a thickener and viscosity modifier by forming hydrogen-bonded aqueous solutions. It serves as a rate-controlling excipient in compound delivery systems, and finds applications in the food, tissue engineering, nanosensing and industrial fields[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9000-30-0. Pack Sizes: 25 g; 50 g; 100 g; 250 g; 500 g; 1 k g. Product ID: HY-W145516. | |
| Gue1654 | Gue1654 is a modulator of OXE-R. Gue1654 inhibits Gβγ but not Gα signaling triggered upon activation of Gα(I)-βγ by the chemoattractant receptor OXE-R. Gue1654 does not interfere nonspecifically with signaling directly at or downstream of Gβγ[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 397290-30-1. Pack Sizes: 1 mg. Product ID: HY-110114. | |
| Guggulsterone | Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt[1][2]. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC50s of 24.06?μM and 39.05?μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Z/E-Guggulsterone. CAS No. 95975-55-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107738. | |
| Gum ghatti | Gum ghatti is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Indian gum. CAS No. 9000-28-6. Pack Sizes: 10 g; 25 g; 50 g; 100 g. Product ID: HY-W145515. | |
| Gunagratinib | Gunagratinib (ICP-192) is a low toxicity and orally active pan-FGFR (fibroblast growth factor receptors) inhibitor that potently and selectively inhibits FGFR activities irreversibly by covalent binding. Gunagratinib can be used for the research of cancer[1]. Gunagratinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ICP-192. CAS No. 2211082-53-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132817. | |
| Gusacitinib | Gusacitinib (ASN-002) is an orally active dual SYK/JAK kinase inhibitor with IC50 values of 5, 46, 4, 11 and 8 nM for SYK, JAK1, JAK2, JAK3 and TYK2, respectively. Gusacitinib rapidly and significantly suppressed key inflammatory pathways implicated in atopic dermatitis pathogenesis. Gusacitinib can be used in the research of chronic hand eczema and cancers such as basal cell carcinoma[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASN-002. CAS No. 1425381-60-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103018. | |
| Guselkumab | Guselkumab is a recombinant human IgG1 monoclonal antibody against the IL-23p19 subunit. Guselkumab binds to human and cynomolgus monkey IL-23 with Kd values of 3.3 and 1.9 pmol/L, respectively. Guselkumab inhibits production of cytokines lying downstream of the IL-23 signaling pathway and can be used for psoriatic arthritis research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CNTO 1959. CAS No. 1350289-85-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9931. | |
| Gut restricted-7 | Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 has a tissue-selective and is restricted to the gut. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GR-7. CAS No. 2553218-46-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-135747. | |
| Guvacine hydrochloride | Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Uses: Scientific research. Category: Signaling pathways. CAS No. 6027-91-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100809. | |
| Guvacoline hydrobromide | Guvacoline hydrobromide, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal mAChR[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 17210-51-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116490. | |
| Guvacoline hydrochloride | Guvacoline hydrochloride, a pyridine alkaloid found in Areca triandra, can act as a weak full agonist of atrial and ileal muscarinic receptors[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6197-39-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N5016. | |
| GW0742 | GW0742 is a potent PPARβ and PPARδ agonist, with an IC50 of 1 nM for human PPARδ in binding assay, and EC50s of 1 nM, 1.1 μM and 2 μM for human PPARδ, PPARα, and PPARγ, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GW610742. CAS No. 317318-84-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13928. | |
| GW-1100 | GW-1100 is a selective GPR40 antagonist with a pIC50 of 6.9. Uses: Scientific research. Category: Signaling pathways. CAS No. 306974-70-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-50691. | |
| GW1929 | GW 1929 is an orally active peroxisome proliferator-activated receptor-γ (PPARγ) agonist with a pKi of 8.84 for human PPAR-γ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively. GW 1929 (hydrochloride) has antidiabetic efficacy and neuroprotective potential[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 196808-24-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15655. | |
| GW2580 | GW2580 is an orally bioavailable and selective inhibitor of c-Fms kinase which completely inhibits human cFMS kinase in vitro at 0.06 μM. GW2580 acts as a competitive inhibitor of ATP binding to the cFMS kinase and inhibits colony-stimulating-factor-1 signaling[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 870483-87-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-10917. | |
| GW274150 | GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 also displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 exerts a protective role in an acute model of lung injury inflammation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 210354-22-6. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12119. | |
| GW274150 phosphate | GW274150 phosphate is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 phosphate displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 phosphate exerts a protective role in an acute model of lung injury inflammation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 438542-15-5. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12119A. | |
| GW280264X | GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively[1]. ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 866924-39-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115670. | |
| GW2974 | GW2974 is a potent dual inhibitor of EGFR and HER2 with IC50 value of 0.007 μM and 0.016 μM, respectively. GW2974 demonstrates in vitro inhibition of the EGFR and HER2 and inhibits the growth of tumor cell. GW2974 can be used for glioblastoma multiforme (GBM) disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 202272-68-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-112293. | |
| GW311616 hydrochloride | GW-311616 is a potent, orally bioavailable, long duration and selective human neutrophil elastase (HNE) inhibitor with IC50 value of 22 nM and Ki value of 0.31 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GW311616A. CAS No. 197890-44-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-15891A. | |
| GW3965 | GW3965 is a potent, selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 405911-09-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10627. | |
| GW3965 hydrochloride | GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 405911-17-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10627A. | |
| GW 4064 | GW 4064 is a potent FXR agonist with an EC50 of 65 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 278779-30-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-50108. | |
| GW 441756 | GW 441756 is a potent and specific nerve growth factor (NGF) receptor tyrosine kinases A (TrkA) inhibitor (IC50=2 nM), which eliminates the BmK NSPK-induced neurite outgrowth[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 504433-23-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18314. | |
| GW4869 | GW4869 is a noncompetitive neutral sphingomyelinase (N-SMase) inhibitor with an IC50 of 1 μM. GW4869 is an inhibitor of exosome biogenesis/release[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6823-69-4. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-19363. | |
| GW 501516 | GW 501516 (GW 1516) is a PPARδ agonist with an EC50 of 1.1 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GW 1516; GSK-516. CAS No. 317318-70-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-10838. | |
| GW 5074 | GW 5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, and has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 220904-83-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10542. | |
| GW604714X | GW604714X is a potent inhibitor of mitochondrial respiration supported by pyruvate but not other substrates. GW604714X is a highly specific mitochondrial pyruvate carrier (MPC) inhibitor with a Ki <0.1 nM. GW604714X also inhibits L-lactate transport by the plasma membrane monocarboxylate transporter (MCT1), but at concentrations more than 4 orders of magnitude greater than the MPC[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 853953-65-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138559. | |
| GW627368 | GW627368 (GW627368X) is a novel, potent and selective competitive antagonist of prostanoid EP4 receptor with additional human TP receptor affinity, with pKi values of 7.0 and 6.8 for human prostanoid EP4 and TP receptors respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 439288-66-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16963. | |
| GW6340 | GW6340 is an intestinal-specific LXR agonist. GW6340 promotes macrophage reverse cholesterol transport (mRCT)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 405910-78-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-154928. | |
| GW6471 | GW6471 is a selective peroxisome proliferator-activated receptor α (PPARα) antagonist. GW6471 reduces cancer stem cell viability, proliferation, and spheroid formation. GW6471 induces apoptosis and causes metabolic impairment including energy imbalance. GW6471 can be used for the research of paragangliomas and triple-negative breast cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 880635-03-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-15372. | |
| GW7647 | GW7647 is a potent PPARα agonist, with EC50s of 6 nM, 1.1 μM, and 6.2 μM for human PPARα, PPARγ and PPARδ, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 265129-71-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13861. | |
| GW768505A free base | GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC50 of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 501693-25-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125741. | |
| GW779439X | GW779439X is a pyrazolopyridazine identified in an inhibitor of the S. aureus PASTA kinase Stk1. GW779439X potentiates the activity of β-lactam antibiotics against various MRSA and MSSA isolates, some even crossing the breakpoint from resistant to sensitive. GW779439X is an AURKA inhibitor and induces apoptosis by the caspases 3/7 pathway[1][2]. MRSA:methicillin-resistant S. aureus; MSSA: methicillin-sensitive S. aureus. Uses: Scientific research. Category: Signaling pathways. CAS No. 551919-98-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103645. | |
| GW788388 | GW788388 is a potent and selective inhibitor of ALK5 with IC50 of 18 nM, and also inhibits TGF-β type II receptor and activin type II receptor activities, without inhibiting BMP type II receptor. Uses: Scientific research. Category: Signaling pathways. CAS No. 452342-67-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10326. | |
| GW806742X | GW806742X, an ATP mimetic and a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, binds the MLKL pseudokinase domain with a Kd of 9.3 μM. GW806742X has activity against VEGFR2 (IC50=2 nM). GW806742X retards MLKL membrane translocation and inhibits necroptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 579515-63-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112292. | |
| GW 833972A | GW 833972A is a selective CB2 receptor agonist with pEC50 of the human CB2 receptor for GW 833972A of 7.3, and its selectivity for the CB2 receptor is approximately 1000 times higher than that for the CB1 receptor. GW 833972A inhibits induced neuronal depolarization and suppresses coughing caused by citric acid in guinea pig models. GW 833972A can be used for the study of chronic cough[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1092502-33-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-101765. | |
| GW842166X | GW842166X is a potent and selective cannabinoid receptor 2 (CB2) agonist with IC50 values of 63 and 91 nM for human and rat CB2, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 666260-75-9. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14167. | |
| GW8510 | GW8510 is a potent cyclin-dependent kinase-2 (CDK2) inhibitor. GW8510 is also a ribonucleotide reductase M2 (RRM2) inhibitor. GW8510 exhibits neuroprotective and anticancer activities[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 222036-17-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112358. | |
| GW9508 | GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 885101-89-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15589. | |
| GW9508 (Standard) | GW9508 (Standard) is the analytical standard of GW9508. This product is intended for research and analytical applications. GW9508 is a potent and selective G protein-coupled receptors FFA1 (GPR40) and GPR120 agonist with pEC50s of 7.32 and 5.46, respectively. GW9508 shows ~100-fold selectivity for GPR40 over GPR120. GW9508 is inactive against other GPCRs, kinases, proteases, integrins and PPARs. GW9508 is a glucose-sensitive insulin secretagogue and an ATP-sensitive potassium (KATP) channels opener. Anti-inflammatory and anti-atherosclerotic activities[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 885101-89-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15589R. | |
| GW9662 | GW9662 is a potent and selective PPARγ antagonist with an IC50 of 3.3 nM, showing 10 and 1000-fold selectivity over PPARα and PPARδ, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 22978-25-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-16578. | |
| GX-201 | GX-201 is a selective NaV1.7 inhibitor, with an IC50 of <3.2 nM for hNaV1.7[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1788071-27-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131870. | |
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