MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Hericenone C | Hericenone C is a metabolite derived from Hericium erinaceus. Hericenone C inhibits LPS (HY-D1056)-induced NRE:Luc luciferase activity, reduces phosphorylation of p65 and inhibits NF-κB signaling. Hericenone C exhibits neuroprotective effect[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 137592-03-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N16500. |  |
| Hesperadin | Hesperadin is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC50 of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 422513-13-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12054. | |
| Hesperetin | Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce Bcl-2 and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 520-33-2. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-N0168. | |
| Hesperetin 7-O-glucoside | Hesperetin 7-O-glucoside is a typical flavonoid monoglucoside, which is an anti-inflammatory agent and an antihypertensive with orally active. Hesperetin 7-O-glucoside is a commonly used food adjuvant. Hesperetin 7-O-glucoside inhibits human intestinal maltase and human HMG-CoA reductase with Ki of 1.8 mM and 9.8 μM, respectively. Hesperetin 7-O-glucoside has antibacterial activity and can regulate intestinal flora and metabolic homeostasis in mice[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hes-7-G. CAS No. 31712-49-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125130. | |
| Hesperidin | Hesperidin (Hesperetin 7-rutinoside), a flavanone glycoside, is isolated from citrus fruits. Hesperidin has numerous biological properties, such as decreasing inflammatory mediators and exerting significant antioxidant effects. Hesperidin also exhibits antitumor and antiallergic activities[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hesperetin 7-rutinoside. CAS No. 520-26-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-15337. | |
| Hesperin | Hesperin is a bioactive ingredient present in Japanese horseradish (wasabi) and has been shown to be an Nrf2 activator. Uses: Scientific research. Category: Signaling pathways. CAS No. 4430-35-7. Pack Sizes: 5 mg (48.70 mM * 500 μL in Ethanol); 10 mg (48.70 mM * 1 mL in Ethanol). Product ID: HY-101371. | |
| HET0016 | HET0016 is a potent and selective 20-hydroxyeicosatetraenoic acid (20-HETE) synthase inhibitor, with IC50 values of 17.7 nM, 12.1 nM and 20.6 nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis, respectively. HET0016 also is a selective CYP450 inhibitor, which has been shown to inhibit angiogenesis and tumor growth[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 339068-25-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124527. | |
| Hex | Hex is an enolase inhibitor and antimalarial agent with Ki values of 74.4 nM and 269.4 nM for ENO2 and ENO1, respectively. Hex is a NfENO and TbENO inhibitor with IC50s value of 0.14 μM and 2.1 μM, respectively. Hex has antimalarial activity against Plasmodium falciparum 3D7, Naegleria fowleri trophozoites and Plasmodium berghei ANKA strain. Hex has anti-tumor effects against intracranial tumors[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2004714-32-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131904A. | |
| Hex-5-yn-1-ol | Hex-5-yn-1-ol (5-Hexyn-1-ol) is a PROTAC linker that can be used in the synthesis of PROTACs. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5-Hexyn-1-ol. CAS No. 928-90-5. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W015943. | |
| Hexacosanoic acid | Hexacosanoic acid is a very long-chain fatty acid. Abnormally elevated levels of Hexacosanoic acid are closely associated with various diseases, such as X-linked adrenoleukodystrophy, adrenomyeloneuropathy, atherosclerosis, and dementia[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 506-46-7. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-113301. | |
| Hexacosanoyl-L-carnitine | Hexacosanoyl-L-carnitine (hydrochloride) is an ester product. Uses: Scientific research. Category: Signaling pathways. CAS No. 590386-14-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-166327. | |
| Hexa-D-arginine | Hexa-D-arginine (Furin Inhibitor II) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Furin Inhibitor II. CAS No. 673202-67-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1028. | |
| Hexa-D-arginine TFA | Hexa-D-arginine TFA (Furin Inhibitor II TFA) is a stable furin inhibitor with Ki values 106 nM, 580 nM and 13.2 μM for furin, PACE4 and prohormone convertase-1 (PC1), respectively. Hexa-D-arginine TFA blocks Pseudomonas exotoxin A and anthrax toxins toxicity in vitro and in vivo[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Furin Inhibitor II TFA. CAS No. 958204-56-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1028A. | |
| Hexadecanedioic acid mono-L-carnitine ester | Hexadecanedioic Acid Mono-L-carnitine Ester Chloride is an O-acyl-L-carnitine in which the acyl group is specified as hexadecanedioyl. Uses: Scientific research. Category: Signaling pathways. CAS No. 42150-38-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-142333. | |
| Hexadecyl palmitate | Hexadecyl palmitate is an organic compound commonly used in the cosmetic industry as an emollient, thickener and skin conditioning agent. Cetyl palmitate is derived from a mixture of cetyl alcohol (a fatty alcohol) and palmitic acid (a saturated fatty acid). It is often used in skin care products such as moisturizers, lotions, and creams to improve their texture and Helps them glide smoothly on the skin. In addition to its use in cosmetics, cetyl palmitate is used in other industries including pharmaceuticals, food additives and lubricants. Overall, it's considered safe for use in personal care products, but like any other ingredient, it may cause irritation or an allergic reaction in some people. Uses: Scientific research. Category: Signaling pathways. CAS No. 540-10-3. Pack Sizes: 10 g; 25 g; 50 g; 100 g; 500 g; 1 k g. Product ID: HY-W010807. | |
| Hexadimethrine bromide | Hexadimethrine bromide (Polybrene) is a cationic polymer used routinely to enhance the efficiency of retrovirus vector-mediated gene transfer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polybrene; 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide. CAS No. 28728-55-4. Pack Sizes: 50 mg; 100 mg; 500 mg. Product ID: HY-112735. | |
| Hexaethylene glycol monododecyl ether | Hexaethylene glycol monododecyl ether is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. CAS No. 3055-96-7. Pack Sizes: 1 mL; 10 mM * 1 mL in DMSO; 5 mL. Product ID: HY-W250198. | |
| Hexa-His | Hexa-His (6X His Tag) is a commonly used affinity tag made up of six histidine residues. HEXA-HIS can bind to affinity chromatography media containing transition metal ions like nickel (Ni2+) or cobalt (Co2+), making it useful for protein purification[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6X His Tag. CAS No. 64134-30-1. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0294. | |
| Hexahydrocurcumin | Hexahydrocurcumin is one of the major metabolites of curcumin and a selective, orally active COX-2 inhibitor. Hexahydrocurcumin is inactive against COX-1. Hexahydrocurcumin has antioxidant, anticancer and anti-inflammatory activities[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 36062-05-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0929. | |
| Hexa-L-Tyrosine | Hexa-L-Tyrosine is a tyrosine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6934-38-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W142015. | |
| Hexamethonium Bromide | Hexamethonium Bromide is a non-selective ganglionic nicotinic-receptor antagonist (nAChR) antagonist, with mixed competitive and noncompetitive activity. Hexamethonium Bromide has anti-hypertensive activity. Hexamethonium Bromide attenuates sympathetic activity and blood pressure in spontaneously hypertensive animal models[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55-97-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-B0569. | |
| Hexamethylene bisacetamide | Hexamethylene bisacetamide (HMBA) is a differentiation inducer and selective bromine domain inhibitor that can differentiate across the blood-brain barrier. Hexamethylene bisacetamide can induce tumor cell differentiation and inhibit cell proliferation, showing antitumor activity. Hexamethylene bisacetamide induces apoptosis by Notch1, Bcl-2 and p53 signaling pathways. In addition, Hexamethylene bisacetamide improves the obesity phenotype of mice[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HMBA. CAS No. 3073-59-4. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-124284. | |
| Hexamethylphosphoramide | Hexamethylphosphoramide is an orally active polar aprotic solvent, flame retardant additive, and carcinogen. Hexamethylphosphoramide undergoes cytochrome P-450-mediated N-demethylation to Formaldehyde. Hexamethylphosphoramide induces DNA-protein crosslinks. Hexamethylphosphoramide has been linked to nasal tumors (squamous cell carcinoma, adenoid squamous cell carcinoma), squamous metaplasia, rhinitis, tracheitis, and reversible and irreversible infertility[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HMPA. CAS No. 680-31-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 g; 500 g; 1 k g. Product ID: HY-Y1155. | |
| Hexamethylquercetagetin | Hexamethylquercetagetin (Hexa-O-methylquercetagetin; Quercetagetin hexamethyl ether; 3,5,6,7,3',4'-Hexamethoxyflavone) is an orally active NF-κB inhibitor. Hexamethylquercetagetin inhibits NF-κB-derived luciferase activity, reduces phosphorylated p65 and IκBα, Cyclin D1, Bcl-2 and blocks TNFα-induced NF-κB activation. Hexamethylquercetagetin inhibits survival and proliferation of cervical carcinoma cells. Hexamethylquercetagetin suppresses tumor volume and weight in BALB/c nude mouse xenograft models of cervical carcinoma. Hexamethylquercetagetin can be used for the research of cancer, such as cervical carcinoma[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hexa-O-methylquercetagetin; Quercetagetin hexamethyl ether; 3,5,6,7,3',4'-Hexamethoxyflavone. CAS No. 1251-84-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N4308. | |
| Hexaminolevulinate hydrochloride | Hexaminolevulinate (Hexyl 5-aminolevulinate) hydrochloride, a porphyrin precursor, is a photosensitiser that can be used in photodynamic therapy (PDT) for certain tumor. Hexaminolevulinate hydrochloride can improve the visualisation of bladder tumours[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hexyl 5-aminolevulinate hydrochloride; P-1206; 5-Aminolevulinic acid hexyl ester hydrochloride. CAS No. 140898-91-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-16045. | |
| Hexane-1,6-diol | Hexane-1,6-diol is a 6-carbon straight-chain diol with hydroxyl groups at both ends. Hexane-1,6-diol can be used as an additive for drilling fluids. Hexane-1,6-diol can also be used as a substrate in life science-related research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 629-11-8. Pack Sizes: 100 g; 500 g; 1000 g. Product ID: HY-W010505. | |
| Hexane-2,5-dione | Hexane-2,5-dione (2,5-HD) is a cytotoxic agent. Hexane-2,5-dione causes an accumulation of neurofilaments within axons in rats that may lead to their degeneration. Hexane-2,5-dione is promising for research of neurodegenerative diseases (e.g., Alzheimer's, Parkinson's)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2,5-HD. CAS No. 110-13-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 g; 500 g; 1 k g. Product ID: HY-Y0315. | |
| Hexanolamino PAF C-16 | Hexanolamino PAF C-16 (1-O-hexadecyl-2-acetyl-sn-glycero-3-phospho (N,N,N trimethyl) hexanolamine) is a Platelet-activating Factor Receptor (PAFR) Modulator with partial agonist activity. Hexanolamino PAF C-16 induces platelet aggregation and macrophage production but fails to increase [Ca2+]i in platelets, suggesting that PAF receptors may interact with PAF receptors through Ca2+-dependent and -independent pathways. Related to platelet aggregation[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-O-Hexa-decyl-2-acetyl-sn-glycero-3-phospho(N,N,N-trimethyl)-hexanolamine. CAS No. 137566-83-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-132190. | |
| Hexanoyl-coenzyme A triammonium | Hexanoyl-Coenzyme A triammonium (06:0 Coenzyme A) is a medium-chain fatty acyl CoA that is an acyl donor substrate for ghrelin O-acyltransferase (GOAT)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 06:0 Coenzyme A triammonium. CAS No. 799812-81-0. Pack Sizes: 1 mg. Product ID: HY-148869A. | |
| Hexapeptide-11 | Hexapeptide-11 is an anti-aging peptide that can protect fibroblasts from premature cell senescence mediated by oxidative stress. Hexapeptide-11 is also a potential stimulator of hyaluronic acid in keratinocytes, and can enhance skin barrier function by upregulating the expression of HAS2 and EGR3, and downregulating the expression of HYAL2. Hexapeptide-11 can also improve skin elasticity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 161258-30-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P2096. | |
| Hexocyclium methylsulfate | Hexocyclium methylsulfate is a potent mAChR antagonist with pKi values of 8.9, 7.7, 8.4, 8.8 for M1, M2, M3, and M4 subtype, respectively. Hexocyclium methylsulfate has the potential for the research of duodenal ulcer and irritable bowel syndrome[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 115-63-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108171A. | |
| Hexokinase, Yeast | Hexokinase, Yeast catalyzes the phosphorylation of glucose, and is involved in glycolysis. Hexokinase, Yeast participates is also related to energy production, protection of mitochondrial integrity, and cell survival[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9001-51-8. Pack Sizes: 1 KU; 5 KU; 10 KU. Product ID: HY-P2776A. | |
| Hexoprenaline | Hexoprenaline is an orally active and selective β-adrenergic receptor agonist. Hexoprenaline can dilate the bronchi. Hexoprenaline can activate adenylate cyclase and increases 14C-Aminopyrine uptake. Hexoprenaline exhibits anti-infection and anti-inflammmation effect. Hexoprenaline can increase placental weight and blood flow. Hexoprenaline can be used for the researches of inflammation, immunology, infection, endocrinology and neurological disease, such as asthma, chronic bronchitis, sepsis and intoxication of organophosphorus compounds[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3215-70-1. Pack Sizes: 1 mg. Product ID: HY-121185. | |
| Hexyl-β-D-glucopyranoside, 98% | Hexyl-β-D-glucopyranoside, 98% is typically used as a mild nonionic detergent. Uses: Scientific research. Category: Signaling pathways. CAS No. 59080-45-4. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg; 250 mg; 1 g. Product ID: HY-W274569. | |
| Hexylresorcinol | Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of α-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4-Hexylresorcinol. CAS No. 136-77-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-B0986. | |
| HFI-142 | HFI-142 is an insulin-regulated aminopeptidase (IRAP) inhibitor with a Ki of 2.01 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 332164-34-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110259. | |
| H-FluNox | H-FluNox is a selective fluorescent probe that senses labile heme using biomimetic N-oxide deoxygenation to trigger fluorescence. H-FluNox is more than 100-fold selective for labile heme over Fe(II), enabling the discrimination of labile heme from labile Fe(II) pools in living cells. H-FluNox is sensitive enough to detect the subcellular labile heme. (λex=490 nm, λem=535 nm). Uses: Scientific research. Category: Signaling pathways. CAS No. 2897614-59-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D2339. | |
| HG-10-102-01 | HG-10-102-01 is a highly potent, selective, and brain-penetrable LRRK2 inhibitor, with IC50 values of 20.3 and 3.2 nM against wild-type LRRK2 and LRRK2[G2019S], respectively. HG-10-102-01 also inhibits MNK2 and MLK1, with IC50 values of 0.6 and 2.1 μM. HG-10-102-01 can be used for Parkinson's disease (PD) research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1351758-81-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13488. | |
| HG106 | HG106 is an effective SLC7A11 inhibitor. HG106 mediates apoptosis by increasing oxidative stress and endoplasmic reticulum stress, and it has antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 928712-10-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-W451275. | |
| HG6-64-1 | HG6-64-1 (HMSL 10017-101-1) is a B-raf kinase modulator.HG6-64-1 modulates B-raf kinase activity, including the V600E mutant form and the drug-resistant gatekeeper mutation T529I. HG6-64-1 is a germinal center kinase inhibitor. HG6-64-1 induces cell cycle arrest and apoptosis. HG6-64-1 can be used for the research of diffuse large B-cell lymphoma (DLBCL)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HMSL 10017-101-1. CAS No. 1315329-43-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12291. | |
| HG-7-85-01 | HG-7-85-01 is a type II ATP competitive inhibitor of wild-type and gatekeeper mutations forms of Bcr-Abl, PDGFRα, Kit, and Src kinases. HG-7-85-01 inhibits T315I mutant Bcr-Abl kinase, KDR and RET with IC50s of 3 nM, 20 nM and 30 nM, and is only weak or no inhibition of other kinases (IC50>2 μM). HG-7-85-01 inhibits the cell proliferation, which is mediated by the induction of apoptosis, and inhibition of cell-cycle progression[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1258391-13-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-15814. | |
| HG-9-91-01 | HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIK) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SIK inhibitor 1. CAS No. 1456858-58-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15776. | |
| H-γ-Glu-Leu-OH | H-γ-Glu-Leu-OH (γ-Glu-Leu) is a dipeptide consisting of γ-glutamic acid and leucine, terminated by a hydroxyl group[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: γ-Glu-Leu. CAS No. 2566-39-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P4632. | |
| HGC652 | HGC652 is a molecular glue degrader targeting TRIM21 with a TRIM21-dependent nuclear membrane disruption effect. HGC652 binds to the PRY-SPRY domain of TRIM21 with high affinity (Ka=0.061 μM), mediates the interaction between TRIM21 and NUP98, and redirects E3 ligase activity. By triggering the polyubiquitination and proteasomal degradation of nucleoporins (such as NUP155 and GLE1), HGC652 disrupts nuclear membrane integrity, alters nuclear morphology, induces genomic instability, and thereby induces cancer cell death[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3055558-98-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-170430. | |
| H-Glu-Thr-OH | H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide made up of two amino acids—glutamic acid (Glu) and threonine (Thr)—connected by a peptide bond, and it acts as an agonist for the extracellular calcium-sensing receptor (CaSR)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L-α-Glutamyl-L-threonine; Glu-Thr. CAS No. 6875-80-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W843885. | |
| H-(Gly)3-Lys(N3)-OH hydrochloride | H-(Gly)3-Lys(N3)-OH (hydrochloride) is a click chemistry reagent. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2737202-70-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-151782A. | |
| H-Gly-Ala-Hyp-OH | H-Gly-Ala-Hyp-OH is a collagen tripeptide fragment[1]. Uses: Scientific research. Category: Peptides. Alternative Names: Gly-Ala-Hyp. CAS No. 22028-81-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P4231. | |
| H-Gly-Pro-Hyp-OH | H-Gly-Pro-Hyp-OH is a collagen-derived peptide and also a dipeptidyl peptidase-4 inhibitor.\nH-Gly-Pro-Hyp-OH inhibits the activity of dipeptidyl peptidase-4 in vitro. H-Gly-Pro-Hyp-OH binds to the DNA-binding site of the JUN/FOS complex, blocks the formation of the DNA-JUN/FOS complex, and inhibits transcriptional activity. H-Gly-Pro-Hyp-OH is applicable to research related to skin photoaging, UVB-induced skin aging/photoaging, and thrombosis[1][2][3][4]. Uses: Scientific research. Category: Peptides. Alternative Names: Tripeptide 29. CAS No. 2239-67-0. Pack Sizes: 10 mM * 1 mL in Water; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-A0299. | |
| H-Gly-Sar-OH | H-Gly-Sar-OH is a Glycine (HY-Y0966) derivative[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Glycylsarcosine; Gly-Sar. CAS No. 29816-01-1. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-W010276. | |
| hGPR91 antagonist 1 | hGPR91 antagonist 1 (Compound 4c) is a potent and selective GPR91 antagonist with an IC50 of 7 nM for human GPR91[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1314796-00-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126217. | |
| hGPR91 antagonist 3 | hGPR91 antagonist 3 (Compound 5g) is a potent and orally active GPR91 antagonist with IC50s of 35 nM and 135 nM, for human GPR91 and rat GPR91, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1314796-31-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-145919. | |
| Hh-Ag1.5 | Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM[1]. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SAg1.5. CAS No. 612542-14-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124899. | |
| H-His(trt)-OMe hydrochloride | H-His(trt)-OMe hydrochloride is a histidine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 32946-56-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g. Product ID: HY-W022220. | |
| Hh Pathway-IN-1 | Hh Pathway-IN-1, a Hedgehog (Hh) pathway inhibitor, is a potent Gli antagonist. Hh Pathway-IN-1 inhibits Hh pathway functional with an IC50 value of 1.1 μM in C3H10T1/2 cells. Hh Pathway-IN-1 does not inhibit Wnt signaling. Hh Pathway-IN-1 shows anti-proliferative activity. Hh Pathway-IN-1 decreases the GLI1 mRNA expression. Hh Pathway-IN-1 inhibits colony formation in a dose-dependent manner[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 599150-20-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107551. | |
| HHQ16 | HHQ16 is an orally active derivative of Astragaloside IV (HY-N0431). HHQ16 effectively reverses infarction-induced hypertrophy and heart failure by targeted degrading lnc4012/lnc9456 and antagonizing their effects on G3BP2/NF-κB signaling[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2620471-66-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-160706. | |
| HHS-0701 | HHS-0701, a sulfur-triazole exchange (SuTEx) ligand, is a potent tyrosine-reactive prostaglandin reductase 2 (PTGR2) inhibitor. HHS-0701 blocks PTGR2 metabolism of the lipid substrate 15-Keto-PGE2[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2851993-91-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138665. | |
| H-Hyp-Gly-OH | H-Hyp-Gly-OH is a dipeptide containing hydroxyproline and glycine. H-Hyp-Gly-OH promotes the growth of mouse primary fibroblasts on collagen gel. H-Hyp-Gly-OH has potential applications in improving skin by ingesting hydrolyzed collagen. H-Hyp-Gly-OH can be used for metabolic research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7672-35-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P4550. | |
| Hi 76-0079 | Hi 76-0079 (NNC0076-0079; 76-0079) is a lipase inhibitor that specifically targets hormone-sensitive lipase (HSL). Hi 76-0079 inhibits PNPB Hydrolysis in cell lysates of HEK293A cellsoverexpressing Lipe with an IC50 value of 0.1 μM. Hi 76-0079 synergizes with the ATGL inhibitor Atglistatin (HY-15859) to block lipolysis in vitro. Hi 76-0079 can be used for the study of lipid metabolism[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NNC0076-0079; 76-0079. CAS No. 374567-94-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153523. | |
| HIF-1α-IN-2 | HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 suppresses HIF-1α expression by blocking transcription and protein translation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2762315-06-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115903. | |
| HIF-2α agonist 2 | HIF-2α agonist 2 (compound 10) is a HIF-2α agonist with an EC50 value of 1.68 μM at the dose of 20 μM. HIF-2α agonist 2 is non-cytotoxic against 786-O-HRE-Luc cells. HIF-2α agonist 2 can be used for oxygen metabolism research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2750141-15-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153016. | |
| HIF-IN-1 | HIF-IN-1 (Compound 3c) is a hypoxia-inducible factor (HIF)-1 inhibitor. HIF-IN-1 suppresses HIF-1α protein accumulation without affecting the levels of HIF-1α mRNA. HIF-IN-1 shows no obvious cytotoxicity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2393928-76-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146144. | |
| Higenamine | Higenamine (Norcoclaurine), a β2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a α1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion (I/R) injury through selective activation of beta2-adrenergic receptor (β2-AR). Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases[1][2][3][4][5][6][7][8][9][10][11]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Norcoclaurine; Demethyl-Coclaurine. CAS No. 5843-65-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2037. | |
| H-Ile-Lys-Val-Ala-Val-OH | H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating MAPK/ERK1/2 and PI3K/Akt signalling pathways[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 131167-89-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P4322. | |
| H-Ile-Pro-Pro-OH hydrochloride | H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1208862-61-6. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-114424A. | |
| Hinokiflavone | Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 19202-36-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2360. | |
| (-)-Hinokiresinol | (-)-Hinokiresinol (Hinokiresinol; trans-Hinokiresinol) can be isolated from Chamaecyparis obtusa. (-)-Hinokiresinol has weak termiticidal activity but strong antifeedant and repellent activity[1]. Uses: Scientific research. Category: Natural products. Alternative Names: Hinokiresinol; trans-Hinokiresinol. CAS No. 17676-24-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N1134. | |
| Hinokitiol | Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities. Uses: Scientific research. Category: Signaling pathways. Alternative Names: β-Thujaplicin. CAS No. 499-44-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-B2230. | |
| HIPP | HIPP (α-(Hydroxyimino)benzenepropanoic acid) is an inhibitor for human C-terminal binding protein (CtBP), with IC50 of 745 nM and a Kd of 1.3 μM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: α-(Hydroxyimino)benzenepropanoic acid. CAS No. 3682-17-5. Pack Sizes: 25 mg; 50 mg. Product ID: HY-121687. | |
| Hippuric acid | Hippuric Acid is an orally active metabolite. Hippuric Acid can be produced by intestinal microorganisms from the metabolism of polyphenols, benzoic acid. Hippuric Acid decreases NRF2, MMP9 and leads to ROS accumulation. Hippuric Acid activates TGFβ/SMAD signaling. Hippuric Acid improves hyperuricemia and colitis. Hippuric Acid can also be used in cardiovascular disease research[1][2][3][4].[5][6][7][8][9]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Benzoylglycine. CAS No. 495-69-2. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g. Product ID: HY-W016562. | |
| Hippuric acid-d2 | Hippuric acid-d2 is the deuterium labeled Hippuric acid. Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Benzamidoacetic acid-d2. CAS No. 208928-78-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-W016562S1. | |
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