MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Homovanillic acid-d3 | Homovanillic acid-d3 (Vanilacetic acid-d3) is the deuterium labeled Homovanillic acid (HY-N0384). Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Vanilacetic acid-d3. CAS No. 74495-71-9. Pack Sizes: 1 mg. Product ID: HY-N0384S. |  |
| Homovanillic acid-d5 | Homovanillic acid-d5 (Vanilacetic acid-d5) is the deuterium labeled Homovanillic acid (HY-N0384). Homovanillic acid (Vanilacetic acid) is a dopamine metabolite found to be associated with aromatic L-amino acid decarboxylase deficiency, celiac disease, growth hormone deficiency, and sepiapterin reductase deficiency[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Vanilacetic acid-d5. CAS No. 53587-32-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-N0384S2. | |
| Honokiol | Honokiol is a bioactive, biphenolic phytochemical that possesses potent antioxidative, anti-inflammatory, antiangiogenic, and anticancer activities by targeting a variety of signaling molecules. It inhibits the activation of Akt. Honokiol can readily cross the blood brain barrier[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 293100. CAS No. 35354-74-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-N0003. | |
| Honokiol DCA | Honokiol DCA (Honokiol dichloroacetate) is a dichloroacetate analog of Honokiol. Honokiol DCA can inhibit the growth of human prostate cancer cells in vitro and suppress the androgen receptor (AR) protein level[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Honokiol dichloroacetate. CAS No. 1620160-42-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124292. | |
| HOPan | HOPan is a PanK substrate and Pantothenate (HY-B0430) analog. HOPan inhibits CoA levels[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 18679-90-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-139729. | |
| HOR1-C59 | HOR1-C59 is a highly selective Or5v1/Olfr110 agonist with an EC50 of 7.12 nM. HOR1-C59 can improve glucose homeostasis, alleviate obesity and insulin resistance. HOR1-C59 is applicable for obesity-related research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 189574-20-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-186028. | |
| HP590 | HP590 is an orally active, novel and potent STAT3 inhibitor (STAT3 luciferase activity: IC50=27.8 nM; ATP inhibition: IC50=24.7 nM). HP590 shows anti-proliferative activity to gastric cancer cells and induces apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2971855-37-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151480. | |
| HPA-12 | HPA-12 is a blood-brain barrier-permeable small-molecule inhibitor of ceramide transfer protein (CERT) with four stereoisomers (the (1R,3R)-stereoisomer exhibits the highest activity). HPA-12 blocks the transport of ceramide from the endoplasmic reticulum to the Golgi apparatus by binding to the START domain of CERT, leading to intracellular ceramide accumulation and inhibition of sphingomyelin (SM) synthesis. HPA-12 induces endoplasmic reticulum stress via the GRP78/ATF6/CHOP axis and activates mitochondrial autophagy, thereby inhibiting cell growth and inducing apoptosis. In in vivo experiments, HPA-12 significantly reduces the leukemia burden and splenomegaly in mouse models of acute myeloid leukemia (AML) and prolongs survival. HPA-12 is applicable for the research of lipid metabolism in acute myeloid leukemia and Alzheimer's disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 383418-30-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-132182. | |
| HPB | HPB (HDAC6 inhibitor HPB) is a selective HDAC6 inhibitor with an IC50 of 31 nM. HPB exhibits >30-flod selectivity for HDAC6 over HDAC1[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HDAC6 inhibitor HPB. CAS No. 1800066-24-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-130493. | |
| HP-β-CD | HP-β-CD ((2-Hydroxypropyl)-β-cyclodextrin) is a widely used drug delivery vehicle to improve the stability and bioavailability. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (2-Hydroxypropyl)-β-cyclodextrin. CAS No. 128446-35-5. Pack Sizes: 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 500 g; 1 k g. Product ID: HY-101103. | |
| HPG1860 | HPG1860 is an orally active, highly selective and potent FXR agonist, with an EC50 of 18 nM (FXR-luciferase reporter assay). HPG1860 has EC50 values >30.0 μM for TGR5 and 13 other related nuclear receptors (cAMP biological assay). HPG1860 can be used for the research of non-alcoholic steatohepatitis (NASH)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2226133-29-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-169792. | |
| HPGDS inhibitor 1 | HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1033836-12-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10439. | |
| HPH-15 | HPH-15 is an anti-migration compound that inhibits cell migration by binding to hnRNP U or suppressing TGF-β signaling. In addition, HPH-15 can also inhibit epithelial-mesenchymal transition (EMT). HPH-15 holds promise for research in the fields of anti-tumor metastasis and anti-fibrosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1009838-93-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-170964. | |
| H-Phe-Phe-OH | H-Phe-Phe-OH is a peptide made of two phenylalanine molecules; Phenylalanine is an essential amino acid and the precursor for the amino acid tyrosine. Uses: Scientific research. Category: Signaling pathways. CAS No. 2577-40-4. Pack Sizes: 1 g; 5 g; 10 g; 25 g. Product ID: HY-W007970. | |
| H-Phe-Trp-OH | H-Phe-Trp-OH (Phenylalanyltryptophan) is an endogenous metabolite. H-Phe-Trp-OH can be used in the research of hepatocellular carcinoma and tic disorders[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Phenylalanyltryptophan; Phe-Trp. CAS No. 24587-41-5. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-W092109. | |
| HPK1-IN-3 | HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC50 of 0.25 nM. HPK1-IN-3 has IL-2 cellular potency with an EC50 of 108 nM in human peripheral blood mononuclear cells (PBMCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2739844-34-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138568. | |
| HPK1-IN-32 | HPK1-IN-32 is a potent and selective HPK1 inhibitor with an IC50 of 65 nM. HPK1-IN-32 can be used for the research of HPK1 related disorders or diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2766481-17-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148847. | |
| HPK1-IN-34 | HPK1-IN-34 (Compound 143) is a Hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of <100 nM[1]. HPK1-IN-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2380300-99-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153362. | |
| HPMC (Type II,Viscosity:100000mPa.s) | HPMC (Hypromellose; (Hydroxypropyl)methyl cellulose; Celacol HPM 5000) (Type II,Viscosity:100000mPa.s) is a non-ionic polymer obtained via synthetic modification of cellulose. As a hydrophilic matrix material, HPMC prolongs drug release through non-Fickian diffusion, including the diffusion of drugs in the hydrated matrix and the polymer relaxation process[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hypromellose (Type II,Viscosity:100000mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:100000mPa.s); Celacol HPM 5000 (Type II,Viscosity:100000mPa.s). CAS No. 9004-65-3. Pack Sizes: 100 g; 500 g; 1 k g. Product ID: HY-A0104I. | |
| HPMC (Type II,Viscosity:3mPa.s) | HPMC (Type II, Viscosity: 3 mPa.s) is a nonionic polymer prepared via synthetic modification of cellulose. As a hydrophilic matrix material, HPMC prolongs drug release through non-Fickian diffusion, which includes the diffusion of drugs in the hydrated matrix and the polymer relaxation process[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hypromellose (Type II,Viscosity:3mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:3mPa.s); Celacol HPM 5000 (Type II,Viscosity:3mPa.s). CAS No. 9004-65-3. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-A0104K. | |
| HPMC (Type II,Viscosity:5mPa.s) | HPMC (Hypromellose) (Type II,Viscosity:5mPa.s) is a hydrophilic, non-ionic cellulose ether used to form swellable-soluble matrices. HPMC (Type II,Viscosity:5mPa.s) is widely used in agent formulations due to its biocompatibility, uncharged nature, solubility in water and thermoplastic behavior[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hypromellose (Type II,Viscosity:5mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:5mPa.s); Celacol HPM 5000 (Type II,Viscosity:5mPa.s). CAS No. 9004-65-3. Pack Sizes: 1 g; 5 g; 10 g. Product ID: HY-A0104J. | |
| HPMC (Type I,Viscosity:30mPa.s) | Hydroxypropylmethylcellulose (Type I,Viscosity:30mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hypromellose (Type I,Viscosity:30mPa.s); (Hydroxypropyl)methyl cellulose (Type I,Viscosity:30mPa.s); Celacol HPM 5000 (Type I,Viscosity:30mPa.s). CAS No. 9004-65-3. Pack Sizes: 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-A0104A. | |
| HPMC (Type I,Viscosity:4000mPa.s) | HPMC (Hypromellose) (Type I, Viscosity: 4000mPa.s) is a primary sodium alginate and controlled release hydrophilic polymer with an average viscosity of 4000mPa.s. The viscosity of HPMC may change due to concentration, pH, temperature or the presence of metal ions. When the pH is above 10, the viscosity decreases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hypromellose (Type I,Viscosity:4000mPa.s); (Hydroxypropyl)methyl cellulose (Type I,Viscosity:4000mPa.s); Celacol HPM 5000 (Type I,Viscosity:4000mPa.s). CAS No. 9004-65-3. Pack Sizes: 5 g; 10 g. Product ID: HY-A0104D. | |
| HPMC (Viscosity:11250-21000mPa.s) | HPMC (Viscosity:11250-21000mPa.s) is a hydrophilic, non-ionic cellulose ether used to form swellable-soluble matrices. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hypromellose (Viscosity:11250-21000mPa.s); (Hydroxypropyl)methyl cellulose (Viscosity:11250-21000mPa.s); Celacol HPM 5000 (Viscosity:11250-21000mPa.s). CAS No. 9004-65-3. Pack Sizes: 500 mg; 1 g. Product ID: HY-A0104. | |
| HPN-01 | HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and <4.8 for IKK-α, IKK-β and IKK-ε, respectively. HPN-01 displays greater 50-fold selectivity over a panel of more than 50 other kinases, including ALK5, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, and VEGFR-2[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 928655-63-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135366. | |
| HPPD-IN-3 | HPPD-IN-3 (compound 25) is a potent inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD), with IC50 of 10 nM, more potency than Mesotrione (HY-12853)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3024245-46-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161308. | |
| HPPE | HPPE (compound 236) is an orally active, potential Bach1 inhibitor. Bach1 is a transcription factor of the cap'n'collar type alkaline region leucine zipper factor family (CNC-bZip) that regulates mitochondrial metabolism and reduces glucose utilization. HPPE can be used for research in psoriasis, multiple sclerosis, and COPD[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Bach1-IN-1. CAS No. 1325721-55-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153040. | |
| HPPH | HPPH (Photochlor) is a second generation photosensitizer, which acts as a photodynamic therapy (PDT) agent. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Photochlor. CAS No. 149402-51-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13722. | |
| H-Pro-Gly-Pro-OH | H-Pro-Gly-Pro-OH is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. H-Pro-Gly-Pro-OH is perfectly positioned to focus neutrophils on the site required and direct a localized repair response. H-Pro-Gly-Pro-OH activates the transcription of neurotrophins and their receptor genes after cerebral ischemia[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pro-Gly-Pro. CAS No. 7561-51-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P4486. | |
| H-Pro-Hyp-OH | H-Pro-Hyp-OH is a collagen peptide composed of proline (Pro) and hydroxyproline (Hyp). H-Pro-Hyp-OH can be used in research on slowing down facial aging[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Prolylhydroxyproline; Pro-Hyp. CAS No. 18684-24-7. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W337672. | |
| HQ005 | HQ005 is a potent CCNK degrader with an DC50 value of 0.041 μM. HQ005 is a molecular-glue degrader that mediates interactions between target proteins and components of the ubiquitin-proteasome system to cause selective protein degradation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2750644-31-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148523. | |
| HQ461 | HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1226443-41-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144981. | |
| HQNO | HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 341-88-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130055. | |
| HQY1428 | HQY1428 is an orally active CDK12 inhibitor. HQY1428 inhibits DNA replication, causes G2/M arrest in SKOV3 cells, induces DNA double-strand breaks and apoptosis. HQY1428 has anti-tumor activity in the SKOV3 xenograft mouse model. HQY1428 combined with the HER2 inhibitor Lapatinib (HY-50898) in the NCI-N87 xenograft mouse model produces a synergistic therapeutic effect[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3093763-71-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172970. | |
| HR-19011 | HR-19011 is an eIF2α phosphorylation activator targeting heme-regulated inhibitor HRI (EIF2AK1). HR-19011 exhibits growth inhibitory activity against K562 cells with an IC50 value of 3.91?μM. HR-19011 inhibits the growth of hematologic malignancies by targeting HRI to activate the integrated stress response via the HRI-eIF2α-ATF4 axis. HR-19011 shows good safety in vivo. HR-19011 can be used for research on hematologic malignancies (leukemia)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2851820-52-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147831. | |
| HRO761 | HRO761 (Werner syndrome RecQ helicase-IN-1) (example 42) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Werner syndrome RecQ helicase-IN-1. CAS No. 2869954-34-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-148699. | |
| HRS-4642 | HRS-4642 is a high affinity, selective, long-acting, and non-covalent KRASG12D inhibitor with a Kd value of 0.083 nM. HRS-4642 inhibits the binding of KRASG12D to SOS1 or RAF1, thereby blocking the downstream MEK-ERK signaling pathway. HRS-4642 promotes Apoptosis. HRS-4642 alone or combined with Carfilzomib (HY-10455) effectively shapes the tumor microenvironment. HRS-4642 has an anti-cancer effect on pancreatic and colorectal cancers carrying the KRASG12D mutation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2836263-09-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-159127. | |
| HRV-3C protease fuses with GST | HRV-3C protease fuses with GST is a recombinant protease fused with HRV-3C protease and GST, which recognizes the LEVLFQGP polypeptide sequence. HRV-3C protease fuses with GST precisely cleaves between glutamine and glycine-proline residues to remove fusion tags from target proteins. HRV-3C protease fuses with GST exhibits cleavage activity both in vitro in silkworm fat body lysates and in vivo in silkworm larval fat bodies, and achieves functional expression in E. coli and silkworm-baculovirus expression systems. HRV-3C protease fuses with GST can be applied to recombinant protein-related research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2178107-79-2. Pack Sizes: 500 μg; 1 mg. Product ID: HY-E70528. | |
| HRX-0233 | HRX-0233 is a small-molecule MAP2K4 inhibitor. HRX-0233 results in strong tumor shrinkage without any apparent toxicity in H358 KRASG12C-mutant non-small cell lung cancers (NSCLC) in vivo. HRX-0233 efficiently prevents feedback activation of receptor tyrosine kinases (RTKs) upon monotherapy KRAS inhibitor Sotorasib (HY-114277) and causes a more sustained and complete inhibition of MAPK signaling. HRX-0233 is promising for research of AR-negative prostate cancer, lung and colon cancers[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2409140-12-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-159190. | |
| HS-1371 | HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC50 of 20.8 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2158197-70-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114349. | |
| HS-276 | HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 reduces the expression of TNF, IL-6, and IL-1β. HS-276 can be used for rheumatoid arthritis (RA) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2767422-72-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147141. | |
| HS38 | HS38 is a potent, selective, and ATP-competitive inhibitor of death-associated protein kinase 1 (DAPK1) and zipper-interacting protein kinase (ZIPK, also called DAPK3), with Kds of 300 nM and 280 nM, respectively. HS38 is also a PIM3 inhibitor with an IC50 of 200 nM. HS38 can be used for the research of smooth muscle related disorders[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1030203-81-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15847. | |
| HSF1A | HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1)[1]. HSF1A also acts as a specific inhibitor of TRiC/CCT. Chaperonin TCP-1 ring complex (TRiC)/chaperonin containing TCP-1 (CCT) plays a pivotal role in toxin translocation and/or refolding[4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1196723-93-9. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103000. | |
| HSGN-94 | HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2570797-85-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-146811. | |
| HSL-IN-1 | HSL-IN-1 (compound 24b) is a potent and orally active hormone sensitive lipase (HSL) inhibitor (IC50=2 nM) with a significantly reduced reactive metabolite liability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2095156-13-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101509. | |
| HSL-IN-5 | HSL-IN-5 (Example 21) is a hormone sensitive lipase (HSL) inhibitor (IC50: 0.25 μM). HSL-IN-5 can be used for diabetes research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 308830-70-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-164714. | |
| hSMG-1 inhibitor 11e | hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC50 of <0.05 nM. hSMG-1 inhibitor 11e shows>900-fold selectivity over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 μM and 7.1 μM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1402452-10-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124760. | |
| hSMG-1 inhibitor 11j | hSMG-1 inhibitor 11j, a pyrimidine derivative, is a potent and selective inhibitor of hSMG-1, with an IC50 of 0.11 nM. hSMG-1 inhibitor 11j exhibits >455-fold selectivity for hSMG-1 over mTOR (IC50=50 nM), PI3Kα/γ (IC50=92/60 nM) and CDK1/CDK2 (IC50=32/7.1 μM). hSMG-1 inhibitor 11j can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1402452-15-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124719. | |
| HSP27 inhibitor J2 | HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: J2. CAS No. 2133499-85-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124653. | |
| HSP90-IN-23 | HSP90-IN-23 (Comp 12-1) is an inhibitor of heat shock protein 90(HSP90) with an IC50 of 9 nM. HSP90-IN-23 induces apoptosis of tumor cells and arrests the tumor cell cycle in G0/G1 phase. HSP90-IN-23 can be used for cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2944100-30-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149891. | |
| HS-PEG5-CH2CH2NH2 hydrochloride | HS-PEG5-CH2CH2NH2 hydrochloride is a PROTAC linker and belongs to the PEG class. Can be used to synthesize PROTAC molecules. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Thiol-PEG5-amine hydrochloride. CAS No. 1446256-16-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-130872A. | |
| HT-2157 | HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3). Uses: Scientific research. Category: Signaling pathways. Alternative Names: SNAP 37889. CAS No. 303149-14-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100717. | |
| HTH-01-015 | HTH-01-015 is a selective NUAK1/ARK5 inhibitor (IC50 is 100 nM). HTH-01-015 inhibits NUAK1 with >100-fold higher potency than NUAK2 (IC50 of >10 μM). Uses: Scientific research. Category: Signaling pathways. CAS No. 1613724-42-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-12334. | |
| HTH-01-091 | HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor, with an IC50 of 10.5 nM. HTH-01-091 also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK and CLK2. HTH-01-091 can be uesd for breast cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2000209-42-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-122665. | |
| H-Thr(Me)-OH | H-Thr(Me)-OH is a threonine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4144-2-9. Pack Sizes: 10 mM * 1 mL in Water; 5 g; 10 g; 25 g; 100 g. Product ID: HY-W008464. | |
| HTMT dimaleate | HTMT (dimaleate) is a potent histamine H1 and H2 receptor agonist. HTMT (dimaleate) is 4 x 104 times more active than histamine in H2-mediated effects in natural suppressor cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 195867-54-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-101052. | |
| HTRA1-IN-1 | HTRA1-IN-1 is a potent and selective high temperature requirement A serine peptid 1 (HTRA1) inhibitor with an IC50 of 13 nM. HTRA1-IN-1 can be used for the research of HTRA1-related diseases, such as age-related macular degeneration (AMD), osteoarthritis, and rheumatoid arthritis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3052552-04-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-163690. | |
| H-Trp-Trp-Trp-OH | H-Trp-Trp-Trp-OH (Trp-Trp-Trp) is a tripeptide consisting of tryptophan. H-Trp-Trp-Trp-OH has antibacterial activity. H-Trp-Trp-Trp-OH is a human bitter taste receptor hTAS2R14 agonist[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Trp-Trp-Trp. CAS No. 59005-82-2. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P4648. | |
| HTS01037 | HTS01037 is an inhibitor of fatty acid binding; and a competitive antagonist of protein-protein interactions mediated by AFABP/aP2 with a Ki of 0.67 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 682741-29-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101503. | |
| HTS07545 | HTS07545 is a potent sulfide:quinone oxidoreductase (SQOR) inhibitor with an IC50 of 30 nM. HTS07545 reduces the decomposition rate of hydrogen sulfide (H2S). HTS07545 can be used in the research of heart failure and pancreatic ductal adenocarcinoma. Uses: Scientific research. Category: Signaling pathways. CAS No. 118666-03-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144439. | |
| H-Tyr(H2PO3)-OH | H-Tyr(H2PO3)-OH is a tyrosine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 21820-51-9. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg. Product ID: HY-W011778. | |
| Human α-Thrombin (Lyophilized) | Human α-thrombin is a multifunctional serine protease that plays a pivotal role in the coagulation pathway. Human α-thrombin cleaves fibrinogen and converts it into fibrin. Human α-thrombin can stimulate platelet activation and stabilize fibrin polymers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9002-4-4. Pack Sizes: 1 KU. Product ID: HY-114164H. | |
| Human β-defensin-1 | Human β-defensin-1 (HβD-1) is a cysteine-rich cationic skin-antimicrobial peptide (SAP) produced by all epithelial surfaces, but also by circulatory cells and cells of the reproductive tract. Human β-defensin-1 has antimicrobial activities against a broad-sperm bacteria[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HβD-1. CAS No. 452274-53-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2315. | |
| human GIP(3-30), amide | Human GIP(3-30), amide is a high affinity antagonist of the human GIP receptor in vitro. Human GIP(3-30), amide has potential anti-obesity and anti-diabetic effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1884226-05-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P10138. | |
| Human growth hormone-releasing factor | Human growth hormone-releasing factor (Growth Hormone Releasing Factor human) is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Growth Hormone Releasing Factor human; Somatorelin (1-44) amide (human). CAS No. 83930-13-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0089. | |
| Humanin | Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging[1][2]. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 330936-69-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P1928. | |
| Human milk lysozyme | Human milk lysozyme is the lysozyme found in human milk. Human milk lysozyme is thought to be a key defense factor in protecting the gastrointestinal tract of newborns against bacterial infection[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 12671-19-1. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-P3021. | |
| Human PTHrP-(1-36) | Human PTHrP-(1-36) is a secretory form of PTHrP with anticalciuric effects. Human PTHrP-(1-36) enhances beta cell function and proliferation. Human PTHrP-(1-36) can be used in the research of humoral hypercalcemia of malignancy (HHM) and hyperparathyroidism[1][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 172867-62-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-106288. | |
| Human secretin | Human secretin is a 27-amino acid residue C-terminally amidated peptide, which acts on human secretin receptors[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Secretin (28-54), (human). CAS No. 108153-74-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1465. | |
| Human serum albumin | Human serum albumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO-) in the vascular wall, contributing to the reduction of blood pressure[1][2][3]. This product is recombinant Human Serum Albumin expressed in a microbial expression system. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HSA. CAS No. 70024-90-7. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-P1956. | |
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