MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| IDO-IN-7 | IDO-IN-7 (NLG-919 analogue) is a a potent IDO1 inhibitor with an IC50 of 38 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NLG-919 analogue; GDC-0919 analogue. CAS No. 1402836-58-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13983. |  |
| IDOR-1117-2520 | IDOR-1117-2520 is an orally active, potent, selective and reversible CCR6 antagonist. IDOR-1117-2520 antagonizes the CCL20-mediated calcium flow (IC50 = 63 nM) and inhibits β-arrestin recruitment to human CCR6 (IC50 = 30 nM) in cells expressing recombinant human CCR6. IDOR-1117-2520 is found to be a substrate of P-gp/MDR1. IDOR-1117-2520 can be used in the research of autoimmune diseases and skin inflammation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2737274-49-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-162495. | |
| IDOR-4 | IDOR-4 is a type IV CFTR corrector. IDOR-4 restores F508del-CFTR trafficking to the cell surface[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2839901-24-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-158002. | |
| IDO/TDO-IN-1 | IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2033173-01-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128355. | |
| Idoxuridine | Idoxuridine (5-Iodo-2-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM[1]. Idoxuridine shows anti-orthopoxvirus activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5-Iodo-2-deoxyuridine; 5-IUdR; IdUrd. CAS No. 54-42-2. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-B0307. | |
| IDT307 | IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1141-41-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129096. | |
| IEM-1460 | IEM-1460 blocks both AMPA and NMDA glutamate receptor with anticonvulsant effect in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 121034-89-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103230. | |
| Ifebemtinib | Ifebemtinib (BI 853520) is an orally active and potent focal adhesion kinase (FAK) inhibitor (recombinant FAK IC50=1 nM). Ifebemtinib shows anti-proliferative activity against cancer cells. Ifebemtinib inhibits FER Kinase and FES Kinase with IC50s of 900 nM and 1040 nM, respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BI-853520; IN-10018. CAS No. 1227948-82-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122844. | |
| Ifenprodil | Ifenprodil (NP-120), a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM)[1]. Ifenprodil is an α1 adrenergic receptor antagonist. Ifenprodil inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil has reliable inhibitory effects against A/H1N1 strains (EC50 of 6.6 μM). Ifenprodil has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease[2][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NP-120; RC-61-91. CAS No. 23210-56-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12882. | |
| Iferanserin | Iferanserin (S-MPEC) is a selective 5-HT receptor (serotonin receptor) antagonist with an affinity for 5-HT2A receptor. Iferanserin has the potential for internal hemorrhoid disease treatment[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-MPEC. CAS No. 58754-46-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118557. | |
| Ifidancitinib | Ifidancitinib (ATI-50002) is an orally available, potent and selective inhibitor of JAK kinase 1/3 that disrupts γc cytokine signaling. Ifidancitinib is used in the research of allergy, asthma, and autoimmune diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ATI-50002; ATI-502. CAS No. 1236667-40-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109178. | |
| Ifinatamab | Ifinatamab is monoclonal immunoglobulin G1-kappa with anti-human B7 homolog 3 protein (Human B7-H3). Ifinatamab is a glycoforme α immunomodulateur[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DS-7300a Antibody; MABX-9001A Antibody. CAS No. 2484870-90-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99367. | |
| Ifinatamab deruxtecan | Ifinatamab deruxtecan (DS-7300a) is a B7-H3-targeting Antibody-drug conjugate (ADC), which is composed of a humanized anti-B7-H3 monoclonal antibody, an enzymatically cleavable peptide-based linker, and Exatecan derivative (DXd) (HY-13631D). Ifinatamab deruxtecan is a DNA Topoisomerase I inhibitor. Ifinatamab deruxtecan induces Apoptosis. DS-7300a exerts potent antitumor activities against B7-H3-expressing tumors. against rhabdomyosarcoma, endometrial adenocarcinoma and lung adenocarcinoma. Ifinatamab deruxtecan does not exert direct immunomodulatory effects[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DS-7300a; MABX-9001a; I-DXd. CAS No. 2484870-92-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P3371. | |
| IFN alpha-IFNAR-IN-1 hydrochloride | IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) (IC50=2-8 μM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2070014-98-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12836A. | |
| IFNα-IN-1 | IFNα-IN-1 (AJ2-18) is a IFNα inhibitor that inhibits IFN-α production. IFNα-IN-1 can be used for research of inflammation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2700322-66-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-170331. | |
| IFN-γ Antagonist 1 | IFN-γ Antagonist 1 (AYCRDGKIGPPKLDIRKEEKQI) is an interferon-γ (IFN-γ) antagonist. IFN-γ Antagonist 1 inhibits IFN-γ-induced HLR/DR antigen expression in cells. IFN-γ Antagonist 1 can be used in researches of diseases with abnormal immune regulation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 158040-83-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P4717. | |
| Ifosfamide | Ifosfamide is a CNS-penetrant alkylating chemotherapeutic agent with activity against a wide range of tumors. Uses: Scientific research. Category: Signaling pathways. CAS No. 3778-73-2. Pack Sizes: 10 mM * 1 mL in DMSO; 200 mg; 500 mg. Product ID: HY-17419. | |
| iFSP1 | iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. iFSP1 selectively induces ferroptosis in GPX4-knockout cells which overexpressed FSP1. iFSP1 is able to sensitize a variety of human cancer cell lines to the ferroptosis inducer, such as (1S,3R)-RSL3 (HY-100218A)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 150651-39-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136057. | |
| IGF1Rtide | IGF1Rtide can be used as a RET kinase substrate for RET kinase assays[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 172615-51-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10044. | |
| IGF2BP1-IN-1 | IGF2BP1-IN-1 (Compound A11) is a IGF2BP1 inhibitor and inhibits downstream signaling. IGF2BP1-IN-1 binds to IGF2BP1 protein with a KD value of 2.88 nM. IGF2BP1-IN-1 inhibits cancer cells proliferation (IC50: 9 nM for A549 cell, 34 nM for HCT116). IGF2BP1-IN-1 induces cancer cell apoptosis. GF2BP1-IN-1 inhibits tumor growth in A549 xenograft mouse model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3029447-08-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156110. | |
| iGOT1-01 | iGOT1-01 is a potent aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1; GOT1) inhibitor. iGOT1-01 has IC50s of 85 μM and 11.3 μM in MDH coupled GOT1 enzymatic assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 has anti-cancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 882256-55-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124825. | |
| iGP-1 | iGP-1 is a cell-permeable, selective mixed inhibitor of mitochondrial sn-glycerol-3-phosphate dehydrogenase (mGPDH), with IC50s of 6.3 μM and 13.6 μM for rat mGPDH activity and H2O2 production, respectively. iGP-1 specifically blocks the mitochondrial component of the glycerophosphate shuttle without affecting cytosolic GPDH. iGP-1 not only inhibits cell proliferation and glutaminolysis, and enhances glycolysis, but also significantly alters key cellular physiological processes such as apoptosis, ROS production, HIF-1α stability and mitochondrial membrane potential. iGP-1 remains active in neutrophil cultures under both normoxic and hypoxic conditions, and serves as an ideal probe for glycerol-3-phosphate metabolic mechanisms. iGP-1 has been applied to studies on prostate cancer and related metabolic pathways[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 27031-00-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121970. | |
| IGRP(206-214) | IGRP(206-214) is a biological active peptide. IGRP(206-214) corresponds to residues 206-214 of murine islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP). IGRP(206-214) is T cells specific for proinsulin and IGRP induces diabetes in non-obese diabetic (NOD) mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 849069-99-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5489. | |
| IGS-1.76 | IGS-1.76 efficiently inhibits the human NCS-1/Ric8a complex. IGS-1.76 shows a significantly increased affinity for hNCS-1 and is able to modulate the hNCS-1/Ric8a interaction efficiently[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 313480-47-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122579. | |
| IGUANA-1 | IGUANA-1 is a potent and selective ALDH1B1 inhibitor. IGUANA-1 shows no significant mitochondrial toxicity. IGUANA-1 has antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2756014-25-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148466. | |
| IHCH-7086 | IHCH-7086 is a blood-brain barrier-permeable, partial β-arrestin-biased agonist of 5-HT2AR with a Ki of 12.59 nM. IHCH-7086 blocks D-lysergic acid diethylamide-induced head-twitch response in mice and alleviates depression-like behaviors in mice subjected to acute restraint stress or injected with Corticosterone (HY-B1618). IHCH-7086 is applicable to research related to depression[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2957888-70-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-169841. | |
| iHCK-37 | iHCK-37 (ASN05260065) is a potent and specific Hck inhibitor with a Ki value of 0.22 μM. iHCK-37 blocks HIV-1 viral replication with an EC50 value of 12.9 μM. iHCK-37 is used for chronic myeloid leukemia (CML) research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASN05260065. CAS No. 516478-09-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139147. | |
| IHMT-MST1-39 | IHMT-MST1-39 is an orally active inhibitor for MST kinase, with IC50 of 42, 109, 286, 159 nM for MST1, MST2, MST3, MST4. IHMT-MST1-39 activates the AMPK signaling pathway in liver cells, reduces apoptosis of pancreatic β-cells. IHMT-MST1-39 can be used for the studies of type 1 diabetes (T1D) and type 2 diabetes (T2D)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2414484-01-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164595. | |
| IHMT-MST1-58 | IHMT-MST1-58 is a potent, selective mammalian and orally active STE20-like protein 1 kinase (MST1) inhibitor with IC50 value of 23 nM. IHMT-MST1-58 can be used for the research of Type 1/2 diabetes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2414484-25-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151257. | |
| IHMT-PI3Kδ-372 | IHMT-PI3Kδ-372 is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 shows high selectivity over other class I PI3Ks (56~83 fold) and other protein kinases. IHMT-PI3Kδ-372 can be uesd for chronic obstructive pulmonary disease (COPD) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2429889-61-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131910. | |
| IID432 | IID432 is a Trypanosoma cruzi Topoisomerase II inhibitor with an EC50 of 8 ?nM for Trypanosoma cruzi. IID432, a single dose of 25 mg/kg, can achieve relapse-free parasite clearance in mouse models of chronic Chagas disease. IID432 can be used for Chagas disease research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3094992-69-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175741. | |
| i-Inositol | i-Inositol (myo-Inositol) is a compound of sugar alcohols. i-Inositol is involved in a series of biological processes such as insulin signal transduction and cytoskeletal transduction. i-Inositol mainly exists in glial cells and plays an osmotic role[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: myo-Inositol; meso-Inositol. CAS No. 87-89-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g. Product ID: HY-B1411. | |
| i-Inositol-d6 | i-Inositol-d6 is the deuterium labeled i-Inositol. i-Inositol is a chemical compound, associated lipids are found in many foods, in particular fruit, especially cantaloupe and oranges. Uses: Scientific research. Category: Signaling pathways. Alternative Names: myo-Inositol-d6; meso-Inositol-d6. CAS No. 68922-44-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B1411S. | |
| i-Inositol (Standard) | i-Inositol (Standard) is the analytical standard of i-Inositol. This product is intended for research and analytical applications. i-Inositol (myo-Inositol) is a compound of sugar alcohols. i-Inositol is involved in a series of biological processes such as insulin signal transduction and cytoskeletal transduction. i-Inositol mainly exists in glial cells and plays an osmotic role[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: myo-Inositol (Standard); meso-Inositol (Standard). CAS No. 87-89-8. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-B1411R. | |
| IK-175 | IK-175 is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. IK-175 effectively blocks AHR from translocating from the cytoplasm to the nucleus. IK-175 is highly selective for AHR over other receptors, transporters, and kinases[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AHR antagonist 5 free base. CAS No. 2247950-42-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-141609. | |
| IK-595 | IK-595 is a MEK1/MEK2 inhibitor with high affinity (7.39 nM).IK-595 blocks EGF-induced ERK1/2 phosphorylation in AsPC-1 cells with IC50 value of 0.1 nM. IK-595 has oral activity and blood-brain barrier penetration. IK-595 can be used for the research of Ras/MAPK pathway-altered cancers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3018909-73-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-181067. | |
| IK-930 | IK-930 (compound I-32) is a potent and orally active TEAD inhibitor with an EC50 value of <0.1 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2563892-44-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-153585. | |
| Ikarugamycin | Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 36531-78-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-119764. | |
| IKK 16 | IKK 16 is an orally active IKK inhibitor. IKK 16 shows IC50s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC50s of 153.9, 115, and 99.7 nM, respectively. IKK 16 is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 873225-46-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 1 g. Product ID: HY-13687. | |
| IKK 16 hydrochloride | IKK 16 hydrochloride is an orally active IKK inhibitor. IKK 16 hydrochloride shows IC50s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 hydrochloride is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC50s of 153.9, 115, and 99.7 nM, respectively. IKK 16 hydrochloride is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 hydrochloride protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 hydrochloride can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 hydrochloride attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1186195-62-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13687A. | |
| IKK2-IN-4 | IKK2-IN-4 (compound 4) is a potent IKK-2 inhibitor, with an IC50 of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 354811-10-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112456. | |
| Ikshusterol | Ikshusterol is a sterol that can be extracted from Hibiscus moscheutos L[1]. Uses: Scientific research. Category: Natural products. CAS No. 34427-61-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N4017. | |
| IL-17A antagonist 1 | IL-17A antagonist 1 (Compound 1) is an IL-17A antagonist, with a Kd of 0.66 μM and an IC50 of 1.14 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2205034-18-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-101913. | |
| IL-17 modulator 4 | IL-17 modulator 4 is a proagent of IL-17 modulator 1 (HY-141535). IL-17 modulator 1 is an orally active, highly efficacious IL-17 modulator. IL-17 modulator 4 is promising for the research of IL-17A mediated diseases, including inflammation, autoimmune diseases, infectious diseases, cancer, and precancerous syndrome[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2446803-65-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141692. | |
| IL-23R inhibitor peptide-1 | IL-23R inhibitor peptide-1 (comp 475) is an interleukin-23 receptor inhibitor, with an IC50 of 0.0069 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2894052-23-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P10723. | |
| IL4I1-IN-1 | IL4I1-IN-1 (Compound Ex 232 pg 200) is a selective interleukin 4-induced protein 1 (IL4I1) inhibitor with an EC50 of 2 nM. IL4I1-IN-1 inhibits IL4I1-mediated oxidative deamination of phenylalanine, reducing the production of phenylpyruvate, H2O2 and NH3. IL4I1-IN-1 is promising for research of cancers with high IL4I1 expression, such as endometrial carcinoma, ovarian cancer, and triple-negative breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3082703-49-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-174262. | |
| IL-4-inhibitor-1 | IL-4-inhibitor-1 (compound 52) is an IL-4 inhibitor, with an EC50 of 1.81 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1332184-63-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139092. | |
| Iladatuzumab | Iladatuzumab (MCDS0593A) is a humanized IgG1 anti-human CD79B monoclonal antibody. Iladatuzumab can be used to synthesize antibody-drug conjugates (ADC) Iladatuzumab vedotin (DCDS0780A; HY-P99657), which has the potential for B-cell non-Hodgkin lymphoma (B-NHL) research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MCDS0593A. CAS No. 1906205-76-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99656. | |
| Ilaprazole | Ilaprazole (IY-81149) is an orally active proton pump inhibitor. Ilaprazole irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with an IC50 of pump inhibitory activity of 6 μM in rabbit parietal cell preparation. Ilaprazole is used for the research of gastric ulcers. Ilaprazole is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IY-81149. CAS No. 172152-36-2. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101664. | |
| Ile-Phe | Ile-Phe is a dipeptide that self-associates in aqueous solution to form a transparent thermoreversible gel formed by a network of fibrillar nanostructures. It may be involved in triggering self-assembly processes such as amyloid formation. Uses: Scientific research. Category: Signaling pathways. Alternative Names: H-Ile-Phe-OH. CAS No. 22951-98-0. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-P4637. | |
| Ilexgenin A | Ilexgenin A is a pentacyclic triterpenoid, which extracted from Ilex hainanensis Merr. Ilexgenin A can be used for the research of inflammation and cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 108524-94-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-N6255. | |
| Ilginatinib hydrochloride | Ilginatinib hydrochloride (NS-018 hydrochloride) is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM). Uses: Scientific research. Category: Signaling pathways. Alternative Names: NS-018 hydrochloride. CAS No. 1239358-85-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 1 g. Product ID: HY-19631B. | |
| Ilicicolin H | Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) (IC50 = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC50 = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with KD of 60 μM.Ilicicolin H can inhibit cell proliferation and induce apoptosis. Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans, Cryptococcus and A. fumigatus. Ilicicolin H can be used for the researches of cancer and infection, such as hepatocellular carcinoma (HCC) and C. albicans infection[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 12689-26-8. Pack Sizes: 500 μg. Product ID: HY-N8540. | |
| Illudin S | Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1149-99-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-125098. | |
| Ilomastat | Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1). Uses: Scientific research. Category: Signaling pathways. Alternative Names: GM6001; Galardin. CAS No. 142880-36-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15768. | |
| Iloperidone | Iloperidone (HP 873) is a D2/5-HT2 receptor antagonist. Iloperidone is an atypical antipsychotic for the schizophrenia symptoms[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HP 873. CAS No. 133454-47-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-17410. | |
| Iloperidone metabolite Hydroxy Iloperidone | Iloperidone metabolite Hydroxy Iloperidone (P88; Hydroxy Iloperidone) is an active reduced metabolite of Iloperidone (HY-17410). Iloperidone metabolite Hydroxy Iloperidone can be used for the research of schizophrenia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: P88; Hydroxy Iloperidone. CAS No. 133454-55-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-G0003. | |
| Iloprost | Iloprost (ZK 36374; Ciloprost) is a prostacyclin (PGI2) analogue, involves in embryo development and inflammation improvement, and inhibits tumor metastasis. Iloprost can be used for peripheral vascular research[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ciloprost; ZK 36374. CAS No. 78919-13-8. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0096. | |
| Ilorasertib hydrochloride | Ilorasertib (ABT-348) hydrochloride is a potent, orally active and ATP-competitive aurora inhibitor with IC50s of116, 5, 1 nM for aurora A, aurora B, aurora C, respectively. Ilorasertib hydrochloride also is a potent VEGF, PDGF inhibitor. Ilorasertib hydrochloride has the potential for the research of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-348 hydrochloride. CAS No. 1847485-91-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16018A. | |
| ILS-920 | ILS-920 is a nonimmunosuppressive Rapamycin analog with reduced immunosuppressive activity and potent neuroprotective activity. ILS-920 binds selectively to the immunophilin FKBP52 and to the β1-subunit of L-type voltage-gated calcium channels (VGCC). ILS-920 shows 200-fold selectivity for FKBP52 versus FKBP12[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 892494-07-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-106345. | |
| Ilunocitinib | Ilunocitinib (compound 27) is a JAK inhibitor (extracted from patent WO2009114512A1)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY-3411067. CAS No. 1187594-14-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132819. | |
| Iluzanebart | Iluzanebart is a human monoclonal IgG1 antibody and is the agonist antibody for human TREM2 (hTREM2). Iluzanebart improves the survival and function of microglia by activating the TREM2 signaling pathway to compensate for the loss of CSF1R function. Iluzanebart can be used for research of adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VGL101. CAS No. 2733621-19-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990043. | |
| IM-12 | IM-12 is an inhibitor of GSK-3β, with an IC50 of 53 nM, and also enhances Wnt signalling. Uses: Scientific research. Category: Signaling pathways. CAS No. 1129669-05-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12292. | |
| IM-54 | IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H2O2-induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 861891-50-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108351. | |
| IMAB027 | IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6+ ovarian and testicular cancer cell lines[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASP1650. CAS No. 1650599-68-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99413. | |
| iMAC2 hydrochloride | iMAC2 hydrochloride is a potent MAC (mitochondrial apoptosis-induced channel) inhibitor, with an IC50 of 28 nM and a LD50 of 15000 nM. iMAC2 hydrochloride shows anti-apoptotic effect. iMAC2 hydrochloride blocks cytochrome c release[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 335166-00-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-110073. | |
| Imalumab | Imalumab (BAX69) is a recombinant, human IgG1 monoclonal antibody that targets macrophage inhibitory factor (MIF). Imalumab can be used for the research of ovarian carcinoma, recurrent malignant ascites and cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAX69; Anti-Human MIF Recombinant Antibody. CAS No. 1430205-07-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99262. | |
| Imaradenant | AZD4635 (HTL1071) is a potent, selective and orally active adenosine A2A receptor (A2AR) antagonist. AZD4635 binds to human A2AR with a Ki of 1.7 nM and shows >30-fold selectivity over other adenosine receptors[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HTL1071; AZD4635. CAS No. 1321514-06-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101980. | |
| Imatinib | Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively[1][2][3][4]. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV[5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: STI571; CGP-57148B. CAS No. 152459-95-5. Pack Sizes: 10 mM * 1 mL in DMSO; 200 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-15463. | |
| Imatinib-d4 | Imatinib-d4 (STI571-d4) is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: STI571 d4; CGP-57148B d4. CAS No. 1134803-16-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-15463S1. | |
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