MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Indatuximab ravtansine | Indatuximab ravtansine (BT-062) is an antibody-drug conjugate (ADC) based on a murine/human chimeric form of B-B4 (specific for CD138), linked to the maytansinoid agent DM4 by disulphide bonds. Indatuximab ravtansine shows anti-tumor activities[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BT-062; nBT062-DM4. CAS No. 1238517-16-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-141607. |  |
| Indazole-Cl | Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced in?ammation in vascular smooth muscle cells (VSMCs)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ind-Cl. CAS No. 848142-62-1. Pack Sizes: 1 mg. Product ID: HY-137004. | |
| Indeglitazar | Indeglitazar (PPM 204) is an orally available PPAR pan-agonist for all three PPARα, PPARδ and PPARγ[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PPM 204. CAS No. 835619-41-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14817. | |
| Indimitecan | Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LMP776. CAS No. 915360-05-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18350. | |
| Indinavir | Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CLpro inhibitor[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-639 free base; L-735524 free base. CAS No. 150378-17-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-B0689. | |
| Indinavir sulfate | Indinavir sulfate (MK-639) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate is also a SARS-CoV 3CLpro inhibitor[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-639; L735524. CAS No. 157810-81-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-B0689A. | |
| Indirubin | Indirubin (Couroupitine B) is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Couroupitine B; Indigo red; Indigopurpurin. CAS No. 479-41-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-N0117. | |
| Indirubin-3'-monoxime | Indirubin-3'-monoxime is a potent GSK-3β inhibitor, and weakly inhibits 5-Lipoxygenase, with IC50s of 22 nM and 7.8-10 μM, respectively; Indirubin-3'-monoxime also shows inhibitory activities against CDK5/p25 and CDK1/cyclin B, with IC50s of 100 and 180 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Indirubin-3'-oxime. CAS No. 160807-49-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19807. | |
| Indisulam | Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: E 7070. CAS No. 165668-41-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13650. | |
| Indo-1 AM | Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues.MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Indo-1 Acetoxymethyl ester. CAS No. 112926-02-0. Pack Sizes: 1 mg. Product ID: HY-101898. | |
| Indocyanine green | Indocyanine green (Foxgreen) is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography (Ex/Em = 785/813 nm)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Foxgreen; IC Green; Cardiogreen. CAS No. 3599-32-4. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-D0711. | |
| Indocyanine green (Standard) | Indocyanine green (Standard) is the analytical standard of Indocyanine green. This product is intended for research and analytical applications. Indocyanine green (Foxgreen) is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Foxgreen (Standard); IC Green (Standard); Cardiogreen (Standard). CAS No. 3599-32-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D0711R. | |
| (-)-Indolactam V | (-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Indolactam V. CAS No. 90365-57-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12307. | |
| Indole | Indole is an aromatic, heterocyclic, organic compound which widely distributed in the natural environment and can be produced by a variety of bacteria. Indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence as an intercellular signal molecule[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 120-72-9. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-W001132. | |
| Indole-13C | Indole-13C is the 13C labeled Indole[1]. Indole is an endogenous metabolite. Uses: Scientific research. Category: Signaling pathways. CAS No. 85597-55-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W001132S1. | |
| Indole-3-acetyl glutamate | Indole-3-acetyl glutamate (IAGlu) is a derivative of the plant hormone indole-3-acetic acid (IAA). As a conjugated form of IAA, Indole-3-acetyl glutamate involves in the transport, storage, and homeostatic regulation of IAA within the plant. Indole-3-acetyl glutamate can be used for research into the effects of plant hormones on the growth and development of plants[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IAGlu. CAS No. 57105-48-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-W588263. | |
| Indole-3-amidoxime | Indole-3-amidoxime is a synthetic intermediate useful for pharmaceutical synthesis. Uses: Scientific research. Category: Signaling pathways. CAS No. 95649-37-9. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W590911. | |
| Indole-3-butyric acid | Indole-3-butyric acid (3-indolebutyric acid) is a plant growth auxin and a good rooting agent. It can promote herbs and woody ornamental plant rooting and used for improving fruit rate. Indole 3-butyric acid is an auxin precursor, and is converted to indole 3-acetic acid (IAA) in a peroxisomal β-oxidation process[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Indolebutyric acid. CAS No. 133-32-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g. Product ID: HY-N0186. | |
| Indole-3-carbinol | Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Indole-3-methanol. CAS No. 700-06-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g. Product ID: HY-N0170. | |
| Indole-3-carboxaldehyde | Indole-3-carboxaldehyde (3-Formylindole), a banlangen extract, is the product of the oxidative degradation of indole-3-acetic acid (IAA) by crude enzyme preparations from etiolated pea seedlings. Indole-3-carboxaldehyde is a biochemical used to prepare analogs of the indole phytoalexin cyclobrassinin. Indole-3-carboxaldehyde also enhances the epithelial barrier and anti-inflammatory activity in the intestinal tract[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3-Formylindole. CAS No. 487-89-8. Pack Sizes: 100 mg. Product ID: HY-W007376. | |
| Indole-3-carboxylic acid | Indole-3-carboxylic acid is an orally active urinary indolic tryptophan metabolite. Indole-3-carboxylic acid is a mediator of priming against Plectosphaerella cucumerina. Indole-3-carboxylic acid enhances the anti-colorectal cancer potency of Doxorubicin (HY-15142A) by inducing cell senescence. Indole-3-carboxylic acid can be used in liver disease research[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 771-50-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-40161. | |
| Indole-3-glyoxylamide | Indole-3-glyoxylamide (Compound 4) is a type of indole alkaloid. Indole-3-glyoxylamide shows no significant cytotoxic activity against Hela, Ishikawa, and MGC-803 cells[1]. Uses: Scientific research. Category: Natural products. Alternative Names: 3-Indoleglyoxamide. CAS No. 5548-10-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N4012. | |
| Indole-3-pyruvic acid | Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 392-12-1. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-W028393. | |
| Indole-3-pyruvic acid (Standard) | Indole-3-pyruvic acid (Standard) is the analytical standard of Indole-3-pyruvic acid. This product is intended for research and analytical applications. Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 392-12-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W028393R. | |
| Indole-d6 | Indole-d6 is the deuterium labeled Indole. Indole is an endogenous metabolite. Uses: Scientific research. Category: Signaling pathways. CAS No. 104959-27-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W001132S. | |
| Indole-d7 | Indole-d7 is the deuterium labeled Indole[1]. Indole is an endogenous metabolite. Uses: Scientific research. Category: Signaling pathways. CAS No. 73509-20-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W001132S4. | |
| Indolelactic acid | Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity[1][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Indole-3-lactic acid. CAS No. 1821-52-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113099. | |
| Indolelactic acid-d5 | Indolelactic acid-d5 is the deuterium labeled Indolelactic acid. Indolelactic acid is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Indole-3-lactic acid-d5. CAS No. 2470130-19-7. Pack Sizes: 1 mg. Product ID: HY-113099S. | |
| Indolicidin | Indolicidin is a potent antimicrobial peptide purified from the cytoplasmic granules of bovine neutrophils. Uses: Scientific research. Category: Signaling pathways. CAS No. 140896-21-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0261. | |
| Indomethacin | Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research[1][2][3]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Indometacin. CAS No. 53-86-1. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-14397. | |
| Indomethacin methylester | Indomethacin methylester (Compound 10; Indometacin methylester) is a potent and selective AKR1C3 inhibitor with an IC50 value of 5.67 μM. Indomethacin methylester is promising for research of postate cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Indometacin methylester. CAS No. 1601-18-9. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 250 mg; 1 g. Product ID: HY-W024692. | |
| Indomethacin (Standard) | Indomethacin (Standard) is the analytical standard of Indomethacin. This product is intended for research and analytical applications. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Indometacin (Standard). CAS No. 53-86-1. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-14397R. | |
| Indoprofen | Indoprofen ((±)-Indoprofe) activates AKT-AMPK signaling pathway, inhibits NF-κB/MAPK signaling pathway. Indoprofen exhibits anti-inflammatory and immunomodulatory activities. Indoprofen is orally active[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-Indoprofe. CAS No. 31842-01-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1104. | |
| Indoramin | Indoramin is an orally active antihypertensive agent. Indoramin is also selective for the α1A-adrenoceptor[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Indoramine; Wy 21901. CAS No. 26844-12-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12760. | |
| Indotecan | Indotecan (LMP-400), an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC50s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LMP-400; NSC-724998. CAS No. 915303-09-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18351. | |
| Indoximod | Indoximod (1-Methyl-D-tryptophan) is an orally active indoleamine 2,3-dioxygenase (IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulating mTOR. Indoximod is an immunometabolic adjuvant used for the research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-Methyl-D-tryptophan; NLG-8189. CAS No. 110117-83-4. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-16724. | |
| Indusatumab | Indusatumab (5F9 Monoclonal antibody) is a monoclonal antibody against human GUCY2C (Guanylate cyclase 2C). Indusatumab fails to bind to granulocytes or erythrocytes. Indusatumab can be used to synthesize ADCs, such as Indusatumab vedotin (HY-P99662). Indusatumab can be used in cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5F9 Monoclonal antibody; TAK-164 Antibody. CAS No. 1497400-26-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99232. | |
| INDY | INDY is a potent and ATP-competitive Dyrk1A and Dyrk1B inhibitor with IC50s of 0.24 μM and 0.23 μM, respectively. INDY binds in the ATP pocket of the enzyme and has a Ki value of 0.18 μM for Dyrk1A. INDY sharply reduces the self-renewal capacity of normal and tumorigenic cells in primary Glioblastoma (GBM) cell lines and neural progenitor cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1169755-45-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108476. | |
| Inebilizumab | Inebilizumab is an anti-CD19 monoclonal antibody (mAb) with enhanced antibody-dependent cell-mediated cytotoxicity against B cells. Inebilizumab can be used for multiple sclerosis and neuromyelitis optica research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MEDI-551. CAS No. 1299440-37-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P99113. | |
| Inecalcitol | Inecalcitol (TX 522), a unique vitamin D3 analog, is an orally active vitamin D receptor (VDR) agonist with a Kd of 0.53 nM. Inecalcitol can induce cell apoptosis and has potent anticancer activities[1][2][3][4]. Inecalcitol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TX 522. CAS No. 163217-09-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-32344. | |
| INF39 | INF39 is an irreversible and noncytotoxic NLRP3 inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 866028-26-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101868. | |
| INF7 | INF7 is a derivative of the N-terminal domain of the HA2 protein and is sensitive to pH. INF7 disrupts the stability of endosomal membranes through a mechanism independent of membrane fusion. INF7 can be used to enhance the endosome escape of complex or liposome-encapsulated proteins. Co-encapsulation of INF7 and molecular imaging probes in liposomes can enhance intracellular signaling and probe retention[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 185462-59-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10152. | |
| Infigratinib | Infigratinib (BGJ-398; NVP-BGJ398) is a potent inhibitor of the FGFR family with IC50s of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BGJ-398; NVP-BGJ398. CAS No. 872511-34-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-13311. | |
| Infigratinib-Boc | Infigratinib-Boc is a derivative of Infigratinib containing a Boc (t-Butyloxy carbonyl) group. Infigratinib is an ATP-competitive pan-FGFR inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2504949-83-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160124. | |
| Inflachromene | Inflachromene, a microglial inhibitor, binds to HMGB1 and HMGB2 and exerts anti-inflammatory effects. Inflachromene effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage. Inflachromene can be used for the research of neuroinflammatory disorders[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 908568-01-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113772. | |
| Infliximab | Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α. Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2). Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research[1][2]. The component ratio of this product is Active ingredient : Excipients = 9 : 47. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Avakine; CT-P13; SB2; TA-650. CAS No. 170277-31-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P9970. | |
| Influenza A NP(366-374) Strain A/PR/8/35 | Influenza A NP(366-374) Strain A/PR/8/35 is an H2-Db-restricted epitope from Influenza A/PR/8/35 nucleoprotein[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 132326-73-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1788. | |
| Ingenol 3,20-dibenzoate | Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 59086-90-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-137295. | |
| Ingenol Mebutate | Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ingenol 3-angelate; PEP005. CAS No. 75567-37-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0719. | |
| INH154 | INH154 is a highly potent inhibitor for Nek2 and Hec1 binding (INH), with IC50s of 200 nM and 120 nM for INH in Hela and MB468 cells. Uses: Scientific research. Category: Signaling pathways. CAS No. 1587705-63-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117154. | |
| INI-43 | INI-43 is an inhibitor of Kpnβ1, interfering with the nuclear localization of Kpnβ1 and known Kpnβ1 cargo proteins, NFAT, NFκB, AP-1, and NFY. INI-43 can inhibit the proliferation of cancer cells, cause G2-M cell cycle arrest in cancer cells, and induce the intrinsic apoptosis pathway[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 881046-01-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121607. | |
| Iniparib | Iniparib (BSI-201) is an irreversible inhibitor of PARP1, used in the research of triple negative breast cancer. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BSI-201; NSC-746045; IND-71677. CAS No. 160003-66-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12015. | |
| INNO-220 | INNO-220 is an orally active, CRBN-dependent molecular glue degrader targeting CK1α. INNO-220 induces cell cycle arrest at G0/G1 phase and triggers apoptosis by degrading CK1α. INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, thereby inhibiting NF-κB signaling in stimulated T cells and lymphoma cells that harbor an activating mutation in CARD11. INNO-220 provides a new direction for lymphoma research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3032576-92-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-174371. | |
| Inobrodib | Inobrodib (CCS1477) is an orally active, potent, and selective inhibitor of the p300/CBP bromodomain. Inobrodib binds to p300 and CBP with Kd values of 1.3 and 1.7 nM, respectively, and with 170/130-fold selectivity compared with BRD4 with a Kd of 222 nM. CCS1477 inhibits cell proliferation in prostate cancer cell lines and decreases androgen receptor (AR)- and C-MYC-regulated gene expression[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CCS1477. CAS No. 2222941-37-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111784. | |
| Inolitazone dihydrochloride | Inolitazone dihydrochloride (Efatutazone dihydrochloride) is a novel high-affinity PPARγ agonist that is dependent upon PPARγ for its biological activity with IC50 of 0.8 nM for growth inhibition. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Efatutazone dihydrochloride; CS-7017 dihydrochloride; RS5444 dihydrochloride. CAS No. 223132-38-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14792B. | |
| Inosine | Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors[1][2][3]. Uses: Scientific research. Category: Induced disease models products. CAS No. 58-63-9. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 25 g; 50 g; 100 g. Product ID: HY-N0092. | |
| Inosine-13C5 | Inosine-13C5 is the 13C5 labeled Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 503173-79-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N0092S2. | |
| Inosine-15N4 | Inosine-15N4 is the 15N labeled Inosine[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 204634-01-5. Pack Sizes: 1 mg. Product ID: HY-150792S. | |
| Inosinic acid | Inosinic acid is an endogenous metabolite. Inosinic acid is used as umami tastant, or as the dietary supplement to improve the yield and meat quality of pigs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5'-IMP; IMP; Inosine 5'-dihydrogen phosphate. CAS No. 131-99-7. Pack Sizes: 10 mM * 1 mL in Water; 25 mg; 50 mg; 100 mg. Product ID: HY-108213. | |
| Inositol nicotinate | Inositol nicotinate (Hexanicit) has vasodilating effects and can be used in research on peripheral arterial disease, showing efficacy when taken orally. Inositol nicotinate does not significantly improve triglyceride levels in mice induced by biphenyl esters[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Inositol niacinate; Hexanicit. CAS No. 6556-11-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-122365. | |
| Inotersen | Inotersen (GSK-2998728; ISIS-420915) is a 2'-O-methoxyethyl-modified antisense oligonucleotide and transthyretin (TTR) inhibitor with low genotoxicity. Inotersen triggers RNase H1-mediated degradation by binding to TTR mRNA, thereby effectively reducing the production of both mutant and wild-type transthyretin in the liver. Inotersen significantly reduces amyloid fiber deposition, yet specific toxicities such as inflammation or tumors are observed at high doses in some animal models. Inotersen is used in studies of hereditary transthyretin amyloidosis and the associated polyneuropathy and cardiomyopathy[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK-2998728; ISIS-420915. CAS No. 1492984-65-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-112974. | |
| Inotersen sodium | Inotersen (ISIS-420915) sodium is a 2-O-methoxyethyl-modified antisense oligonucleotide. Inotersen sodium inhibits the production of transthyretin (TTR) protein by targeting the TTR RNA transcript and reduces the levels of the TTR transcript. Inotersen sodium can be used for the research of hereditary TTR amyloidosis polyneuropathy[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ISIS-420915 sodium. CAS No. 1432726-13-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132608. | |
| Inotodiol | Inotodiol activates p53 signaling pathway, inhibits MMP-2/9, and exhibits antitumor activity in cancer cell HeLa. Inotodiol inhibits the generation of ROS and exhibits antioxidant and neuroprotective effects. Inotodiol inhibits the activation of MAPK and NF-κB signaling pathway, and exhibits anti-inflammatory activity. Inotodiol inhibits TLR-4 mediated TNF-α production (IC50s in BMMC and BMDM is 0.7 μM and 3.0 μM), inhibits the degranulation in mast cell, exhibits anti-allergic activity. Inotodiol is orally active[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 35963-37-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-120149. | |
| Inotuzumab | Inotuzumab (Humanized Anti-CD22 Recombinant Antibody) is a humanized IgG4κ antibody that targets human CD22. Inotuzumab can be linked to a toxic agent Ozogamicin as an antibody-drug conjugate (ADC), Inotuzumab ozogamicin (HY-P9959). Inotuzumab can be used for the research of acute lymphoblastic leukemia and non-Hodgkin lymphoma[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Humanized Anti-CD22 Recombinant Antibody. CAS No. 1660159-36-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P99264. | |
| Inotuzumab ozogamicin | Inotuzumab ozogamicin (CMC-544) is an antibody-targeted chemotherapy agent composed of a humanized anti-CD22 antibody conjugated to Calicheamicin (HY-19609). Inotuzumab ozogamicin and G544 bind human CD22 with similar affinities (Kd ? 150 pM). Inotuzumab ozogamicin has demonstrated efficacy against CD22+ B-cell non-Hodgkins lymphoma. Inotuzumab ozogamicin can be used in the research of acute lymphoblastic leukemia[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CMC-544; PF-5208773; WAY-207294. CAS No. 635715-01-4. Pack Sizes: 100 μg. Product ID: HY-P9959. | |
| inS3-54A18 | inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties. Uses: Scientific research. Category: Signaling pathways. CAS No. 328998-53-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103128. | |
| INSA | INSA is a a pH-sensitive fluorescent probe. INSA can simultaneously light up mitochondria (red emission) and lysosomes (green emission) for their internal pH differences[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2962939-33-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157036. | |
| InsB (9-23) | InsB (9-23) (Insulin B chain (9-23)) is an HLA-DQ8-restricted insulin B-chain peptide composed of amino acid residues 9-23. InsB (9-23) serves as a major MHC II class-restricted antigen. InsB (9-23) supports the recognition and activation of T cells, stimulates the secretion of IFN-γ and cytokines, and induces cross-reactive immune responses. InsB (9-23)-specific CD4 T cells can initiate diabetes. InsB (9-23) can be used in research related to type 1 diabetes and autoimmune diabetes[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Insulin B chain (9-23). CAS No. 163364-16-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1745. | |
| Insect repellent M 3535 | Insect repellent M 3535 (Ethyl butylacetylaminopropionate) is a broad-spectrum, mild insect repellent based on the structure of β-alanine. Insect repellent M 3535 exerts repellent effects by interfering with the olfaction of mosquitoes, but it poses risks of developmental and cardiac toxicity to aquatic organisms such as zebrafish embryos in aquatic environments, and can activate oxidative stress responses[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ethyl butylacetylaminopropionate; IR-3535. CAS No. 52304-36-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-W099479. | |
| Insect repellent M 3535 (Standard) | Insect repellent M 3535 (Ethyl butylacetylaminopropionate) Standard is the analytical standard of Insect repellent M 3535 (HY-W099479). This product is intended for research and analytical applications. Insect repellent M 3535 (Ethyl butylacetylaminopropionate) is a broad-spectrum, mild insect repellent based on the structure of β-alanine. Insect repellent M 3535 exerts repellent effects by interfering with the olfaction of mosquitoes, but it poses risks of developmental and cardiac toxicity to aquatic organisms such as zebrafish embryos in aquatic environments, and can activate oxidative stress responses. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ethyl butylacetylaminopropionate (Standard); IR-3535 (Standard). CAS No. 52304-36-6. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W099479R. | |
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