MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| IR 700DX | IR 700DX (IR 700DX NHS ester) is a near-infrared (NIR) phthalocyanine dye with extremely high photostability and fluorescence intensity. IR 700DX binds to biomolecules. IR 700DX has excellent water solubility, large extinction coefficient, high fluorescence quantum yield, and does not aggregate in high ionic strength buffers. IR 700DX can be used as a highly flexible photosensitizer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IR 700DX NHS ester. CAS No. 916821-46-0. Pack Sizes: 100 μg; 500 μg; 1 mg. Product ID: HY-D2189. |  |
| IR-820 | IR-820 (New Indocyanine Green) is an infrared blood pool contrast agent. IR-820 also is normally used as a laser and near-infrared dye to detect and quantify diseased tissue in live animals[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: New Indocyanine Green. CAS No. 172616-80-7. Pack Sizes: 100 mg; 250 mg. Product ID: HY-136886. | |
| Irafamdastat | Irafamdastat (BMS-986368) (Example 74) is a FAAH and MAGL inhibitor, with IC50s ≤ 100 nM (human FAAH) and 100 nM-1 μM (human MAGL) respectively. Irafamdastat has antiepileptic effect[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-986368; CC-97489; ABX-1772. CAS No. 2244136-58-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-177093. | |
| IRAK-1-4 Inhibitor I | IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC50s of 0.2 μM and 0.3 μM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IRAK-1/4 Inhibitor I. CAS No. 509093-47-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13329. | |
| IRAK4-IN-14 | IRAK4-IN-14 (compound 28) is a potent, selective and orally active IRAK4 inhibitor with an IC50 of 0.003 μM. IRAK4-IN-14 shows good PK parameters in rats and mouse. IRAK4-IN-14 shows synergistic in vitro activity against MyD88/CD79 double mutant ABC-DLBCL in combination with Acalabrutinib[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2667681-71-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146112. | |
| IRAK4-IN-21 | IRAK4-IN-21 (compound 17) is an orally active, potent and selective IRAK4 inhibitor with IC50 values of 5 and 56 nM for IRAK4 and TAK1, respectively. IRAK4-IN-21 effectively inhibits IL-23 production (IC50=0.17 μM) and can be used in studies of autoimmune diseases such as plaque psoriasis and psoriatic arthritis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2170694-04-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-151363. | |
| IRAK4 modulator-2 | IRAK4 modulator-2 (Compound 5) is a selective dual Interleukin-1 Receptor Associated Kinase 4 (IRAK4) and IRAK1 inhibitor with IC50 values of 0.005 μM and 0.97 μM, erespectively. IRAK4 modulator-2 blocks IRAK-mediated signaling pathways (e.g., JAK-STAT, NF-κB pathways), reduces the production of pro-inflammatory cytokines (e.g., IL-1, TNF), and exerts anti-inflammatory activity. IRAK4 modulator-2 is promising for research of autoimmune diseases and inflammatory diseases, such as rheumatoid arthritis, psoriasis, inflammatory bowel disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1356013-27-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-177515. | |
| IRAK-4 Peptide substrate | IRAK-4 Peptide substrate (IRAK-1 (360-380)) is a biological active peptide. (This is a substrate peptide for Interleukin-1 Receptor-Associated Kinase (IRAK) 4). Uses: Scientific research. Category: Signaling pathways. Alternative Names: IRAK-1 (360-380). CAS No. 2837877-90-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5432. | |
| IRAK inhibitor 3 | IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2. Uses: Scientific research. Category: Signaling pathways. CAS No. 1012343-93-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13277. | |
| Irbesartan | Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SR-47436; BMS-186295. CAS No. 138402-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-B0202. | |
| IRBM-Z-1 | IRBM-Z-1 is a non-competitive inhibitor of Zika virus (ZIKV) NS2B-NS3 protease, with an IC50 of 1.8 μM. IRBM-Z-1 also exhibits inhibitory activity against the NS2B-NS3 proteases of T156I-mutated dengue virus 2 (DENV2) and West Nile virus (WNV), with IC50 values of 3.9 μM and 4.7 μM, respectively. IRBM-Z-1 inhibits ZIKV replication, attenuates virus-induced cytopathic effects. IRBM-Z-1 is applicable to research related to ZIKV infection[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 67629-86-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-181990. | |
| IRBP (1-20), human | IRBP (1-20), human contains a major epitope for the H-2b haplotype. IRBP (1-20), human induces experimental autoimmune uveoretinitis (EAU) in H-2b mice[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 298202-25-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1587. | |
| IRBP(651-670) human, mouse | IRBP (651-670) human, mouse is an epitope and uveitis inducer naturally processed from the conserved region of native IRBP. IRBP (651-670) human, mouse increases the levels of proinflammatory cytokines in ocular tissues (IL-1β, IL-6, TNFα, IL-17A and IL-17F). IRBP (651-670) human, mouse is a IRBP fragment conserved among human, mouse and bovine species. IRBP (651-670) human, mouse induces experimental autoimmune uveitis. IRBP (651-670) human, mouse is applicable to research related to experimental autoimmune uveitis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1977546-93-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1924. | |
| [Ir(cod)Cl]2 | [Ir(cod)Cl]2 is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Chloro-1,5-cyclooctadiene iridium(I) dimer. CAS No. 12112-67-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg. Product ID: HY-W008260. | |
| [Ir(Cp-)Cl2]2 | [Ir(Cp-)Cl2]2 is used as a precursor for the asymmetric transfer hydrogenation catalyst of ketones. It is a catalyst for greener amine synthesis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pentamethylcyclopentadienyliridium(III) chloride,dimer. CAS No. 12354-84-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-W018845. | |
| Irdabisant | Irdabisant (CEP-26401) is a selective, orally active and blood-brain barrier (BBB) penetrant histamine H3 receptor (H3R) inverse agonist/inverse agonist with Ki values of 7.2 nM and 2.0 nM for rat H3R and human H3R, respectively. Irdabisant has relatively low inhibitory activity against hERG current with an IC50 of 13.8 μM. Irdabisant has cognition-enhancing and wake-promoting activities in the rat social recognition model. Irdabisant can be used to research schizophrenia or cognitive impairment[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CEP-26401. CAS No. 1005402-19-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-109968. | |
| IRE1α kinase-IN-1 | IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. IRE1α kinase-IN-1 displays 100-fold selectivity for IRE1α over the IRE1β isoform. IRE1α kinase-IN-1 inhibits ER stress-induced IRE1α oligomerization and autophosphorylation, and also inhibits IRE1α RNase activity (IC50=80 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2328097-41-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136735. | |
| IRF1-IN-1 | IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor. IRF1-IN-1 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-1 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1). IRF1-IN-1 has a protective effect on ionizing radiation-induced inflammatory skin injury[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 701225-07-2. Pack Sizes: 10 mg; 25 mg; 50 mg. Product ID: HY-171006. | |
| IRF5-CPP5 | IRF5-CPP5 is a cytosolic peptide that selectively targeting human IRF5 wirh a Kd of 0.53 μM. IRF5-CPP5 disrupts IRF5 homodimerization and inhibits its nuclear translocation without altering IRF5 phosphorylation levels. IRF5-CPP5 inhibits proinflammatory cytokine (IL-6, IL-1β, TNF-α) production. IRF5-CPP5 can be used for the research of systemic lupus erythematosus[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1601299-92-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P11072. | |
| IRF5-IN-1 | IRF5-IN-1 (Compound C5) is a conformationally locked inhibitor for SLC15A4. IRF5-IN-1 blocks the downstream IRF5 activation, inhibits the TLR7/8 signaling pathway. IRF5-IN-1 exhibits anti-inflammatory responses[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 689270-18-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149652. | |
| IRG1-IN-1 | IRG1-IN-1 is an itaconic acid derivative. IRG1-IN-1 can inhibit immune-responsive gene 1 (IRG1) activity. IRG1-IN-1 can be used for the research of cancer, inflammation and autoimmune diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2407652-42-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148335. | |
| iRGD peptide | iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of agents by first binding to αv-integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. Uses: Scientific research. Category: Signaling pathways. Alternative Names: c(CRGDKGPDC). CAS No. 1392278-76-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0122. | |
| Iridium(III) chloride hydrate | Iridium(III) chloride (hydrate) (Iridium trichloride (hydrate)) is a biochemical reagent. Iridium(III) can be used in the research of colon cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Iridium trichloride hydrate. CAS No. 14996-61-3. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W021022. | |
| Iriflophenone | Iriflophenone, isolated from Aquilaria sinensis, stimulates MCF-7 and T-47D human breast cancer cells proliferation[1][2]. Uses: Scientific research. Category: Natural products. CAS No. 52591-10-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N4010. | |
| Irigenin | Irigenin is a is a lead compound, and mediates its anti-metastatic effect by specifically and selectively blocking α9β1 and α4β1 integrins binding sites on C-C loop of Extra Domain A (EDA). Irigenin shows anti-cancer properties. It sensitizes TRAIL-induced apoptosis via enhancing pro-apoptotic molecules in gastric cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 548-76-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 20 mg; 50 mg; 100 mg. Product ID: HY-N2587. | |
| Irinotecan | Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Irinotecan; CPT-11; VAL-413free base. CAS No. 97682-44-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-16562. | |
| Irinotecan hydrochloride | Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Irinotecan hydrochloride; CPT-11 hydrochloride; VAL-413. CAS No. 100286-90-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-16562A. | |
| Irinotecan hydrochloride trihydrate | Irinotecan hydrochloride trihydrate ((+)-Irinotecan hydrochloride trihydrate) is a topoisomerase I inhibitor with antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Irinotecan hydrochloride trihydrate; CPT-11 hydrochloride trihydrate. CAS No. 136572-09-3. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-16568. | |
| Irisflorentin | Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 41743-73-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0268. | |
| IRL-1620 | IRL-1620 is a potent and selective endothelin receptor type B (ETB) agonist with a Ki of 16 pM. Uses: Scientific research. Category: Signaling pathways. CAS No. 142569-99-1. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-16465. | |
| IRL 2500 | IRL 2500 is a potent Endothelin receptor antagonist. IRL 2500 shows IC50 values of 1.3 and 94 nM for ETB and ETA receptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 169545-27-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103460. | |
| Iron dextran | Iron dextran (Fe dextran) can be used in the study of iron-deficiency anemia in animals[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Fe dextran. CAS No. 9004-66-4. Pack Sizes: 5 mL; 25 mL. Product ID: HY-107928. | |
| Iron(II) sulfate heptahydrate, 99% | Iron(II) sulfate heptahydrate, 99% (Ferrous sulfate heptahydrate, 99%) is an orally active iron salt. Iron(II) sulfate heptahydrate, 99% replaces iron found in hemoglobin and myoglobin, allowing for the transportation of oxygen via hemoglobin. Iron(II) sulfate heptahydrate, 99% is mainly used for the prevention of iron-deficiency anemia. Iron(II) sulfate heptahydrate, 99% also has anti-tumor effects on chronic myeloid leukemia and breast cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ferrous sulfate heptahydrate, 99%. CAS No. 7782-63-0. Pack Sizes: 10 mM * 1 mL in Water; 25 g; 50 g; 100 g; 500 g; 1 k g. Product ID: HY-Y1103. | |
| Iron(II) sulfate heptahydrate, for cell culture, 99% | Iron(II) sulfate heptahydrate, for cell culture, 99% (Ferrous sulfate heptahydrate, for cell culture, 99%) is an orally active iron salt. Iron(II) sulfate heptahydrate, for cell culture, 99% replaces iron found in hemoglobin and myoglobin, allowing for the transportation of oxygen via hemoglobin. Iron(II) sulfate heptahydrate, for cell culture, 99% is mainly used for the prevention of iron-deficiency anemia. Iron(II) sulfate heptahydrate, for cell culture, 99% also has anti-tumor effects on chronic myeloid leukemia and breast cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ferrous sulfate heptahydrate, for cell culture, 99%. CAS No. 7782-63-0. Pack Sizes: 25 g; 50 g; 100 g; 500 g; 1 k g. Product ID: HY-Y1103A. | |
| Irosustat | Irosustat is a potent steroid sulfatase inhibitor, with an IC50 of 8 nM, and exhibits anti-breast cancer activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: STX64; BN83495; 667-Coumate. CAS No. 288628-05-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14586. | |
| Irpagratinib | Irpagratinib (ABSK011) is an orally active FGFR4 inhibitor (IC50<10 nM). Irpagratinib inhibits FGFR4 autophosphorylation and blocks signaling from FGFR4 to downstream pathway activation. Irpagratinib has shown high exposure in PK studies in mice, rats, and dogs, and also demonstrated antitumor activity in a subcutaneous xenograft tumor model[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABSK011. CAS No. 2230974-62-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156618. | |
| Irsenontrine | Irsenontrine (E2027) is an orally active and selective phosphodiesterase 9 (PDE9) inhibitor. Irsenontrine can be used for the research of neurological diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: E2027. CAS No. 1429509-82-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132821. | |
| Irucalantide | Irucalantide is kallikrein inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1631160-47-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5536. | |
| iRucaparib-AP6 | iRucaparib-AP6 is a highly efficient and specific PROTAC PARP1 degrader. iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2410557-00-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-130644. | |
| Iruplinalkib | Iruplinalkib (WX-0593) is an orally active and selective ALK/ROS1 inhibitor. Iruplinalkib can effectively inhibit tyrosine autophosphorylation of ALK and mutant ALK, EGFR, with the IC50 between 5.38 and 16.74 nM. Iruplinalkib is also a suppressive agent of the transporter MATE1, MATE2K, P-gp and BCRP. Iruplinalkib can be used in the study of non-small cell lung cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: WX-0593. CAS No. 1854943-32-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-145574. | |
| IS20 | IS20 is a Prokineticin receptor 1 (PKR1) agonist. IS20 diminishes Doxorubicin (HY-15142A) mediated apoptosis and ROS production by activating Akt or MAPK pathways. IS20 protects the heart against Doxorubicin-induced cardiovascular toxicity and improves the survival rate and cardiac function in mouse models. IS20 does not alter the cytotoxicity and antitumor activity of acute DOX treatment in breast cancer cells and MDA-MB-231 xenograft mouse models. IS20 can be used for cancers research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 324561-95-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125807. | |
| ISA-2011B | ISA-2011B is a PIP5K1α inhibitor with promising anticancer effects. Uses: Scientific research. Category: Signaling pathways. CAS No. 1395347-24-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16937. | |
| Isatuximab | Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ch38SB19; hu38SB19; SAR-650984. CAS No. 1461640-62-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9976. | |
| Isatuximab (anti-CD38) | Isatuximab (anti-CD38) is a monoclonal antibody that targets the transmembrane receptor and extracellular enzyme CD38, a protein highly expressed in hematological malignancies, including multiple myeloma. Isatuximab (anti-CD38) exhibits anti-tumor activity through multiple biological mechanisms, including antibody-dependent cell-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cell phagocytosis, and non-crosslinking direct induction of apoptosis. Isatuximab (anti-CD38) also directly inhibits the extracellular enzyme activity of CD38, which is related to many cellular functions[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1461640-62-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9976A. | |
| Isavuconazole | Isavuconazole (BAL-4815) is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAL-4815; RO-0094815. CAS No. 241479-67-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-14273. | |
| Isavuconazole-d4 | Isavuconazole-d4 (BAL-4815-d4) is a deuterium labeled Isavuconazole (BAL-4815). Isavuconazole is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAL-4815-d4; RO-0094815-d4. CAS No. 1346598-58-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-14273S. | |
| Isavuconazole (Standard) | Isavuconazole (Standard) is the analytical standard of Isavuconazole. This product is intended for research and analytical applications. Isavuconazole (BAL-4815) is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis and results in the disruption of fungal membrane structure and function. Isavuconazole is a moderate inhibitor of CYP3A4. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAL-4815 (Standard); RO-0094815 (Standard). CAS No. 241479-67-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14273R. | |
| Isavuconazonium sulfate | Isavuconazonium sulfate (BAL8557-002) is an orally active broad-spectrum antifungal molecule. Isavuconazonium sulfate is a precursor of the triazole antifungal active molecule Isavuconazole. Isavuconazonium sulfate can be used in the study of invasive aspergillosis, mucormycosis, blastomycosis, and Acanthamoeba keratitis[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAL8557-002. CAS No. 946075-13-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100373. | |
| Iscalimab | Iscalimab (CFZ-533) is a non-depleting IGg1 monoclonal antibody targeting CD40 (KD: 0.3 nM). Iscalimab can be used for research of Graves' hyperthyroidism and autoimmune diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CFZ-533; OM11-62MF. CAS No. 2031153-61-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99670. | |
| ISIS 104838 | ISIS 104838 is an antisense oligonucleotide targeting TNF-α. ISIS 104838 specifically binds to human TNF-α mRNA via Watson-Crick base pairing to form a DNA:RNA hybrid duplex, thereby recruiting the ubiquitously expressed intracellular enzyme RNase H to degrade the target mRNA and inhibit TNF-α protein synthesis at the transcriptional level. ISIS 104838 induces moderate, self-limiting thrombocytopenia in cynomolgus monkeys. ISIS 104838 can be used for the study of inflammatory diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 250755-32-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-145726. | |
| ISIS 416858 | ISIS 416858, a single-stranded antisense oligodeoxynucleotide, is a potent and selective inhibitor of FXI mRNA expression. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FXI-ASO; BAY2306001; IONIS-FXIRx. CAS No. 1223657-78-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-134005. | |
| Islatravir | Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively. Islatravir is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-8591. CAS No. 865363-93-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104012. | |
| ISM5939 | ISM5939 is an orally active and selective ENPP1 inhibitor with an IC50 of 0.63 nM for 2,3-cGAMP degradation and 9.28 nM for ATP hydrolysis. ISM5939 has antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2965301-60-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-176708. | |
| ISO-1 | ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MIF Antagonist. CAS No. 478336-92-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-16692. | |
| Isoacteoside | Isoacteoside is a natural product that can significantly inhibit the formation of glycation end products. Isoacteoside regulates the AKT/PI3K/m-TOR/NF-κB signaling pathway, induces apoptosis in OVCAR-3 cell. Isoacteoside exhibits antitumor, anti-inflammatory, anti-obesity and neuroprotective activities[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Isoverbascoside. CAS No. 61303-13-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0022. | |
| Isoagarotetrol | Isoagarotetrol is a natural product isolated from agalwood[1]. Uses: Scientific research. Category: Natural products. CAS No. 104060-61-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N6817. | |
| Isoalantolactone | Isoalantolactone is an apoptosis inducer, which also acts as an alkylating agent. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Isoalantolactone; Isohelenin. CAS No. 470-17-7. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-N0780. | |
| Isoallolithocholic acid | Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3β-Hydroxy-5α-cholanic acid. CAS No. 2276-93-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-B0172A. | |
| Isoamylase | Isoamylase (Glycogen α-1,6-glucanohydrolase) catalyzes the hydrolysis of α-1,6-glycosidic linkages in glycogen, amylopectin and α/β-limit dextrins[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Glycogen α-1,6-glucanohydrolase. CAS No. 9067-73-6. Pack Sizes: 200 U; 800 U. Product ID: HY-E70116. | |
| Isoandrographolide | Isoandrographolide is an orally active NLRP3 inflammasome inhibitor and AKT/GSK-3β/β-catenin pathway inhibitor. Isoandrographolide inhibits the expression of NLRP3, ASC, and caspase-1, and reduces the levels of phosphorylated AKT, phosphorylated GSK-3β, and β-catenin. Isoandrographolide alleviates inflammatory responses, reduces collagen deposition, suppresses epithelial-mesenchymal transition (EMT), induces differentiation of leukemia cells, inhibits the growth of leukemia cells, protects lung and kidney tissues, regulates cytokine levels, and also exhibits hepatoprotective effects. Isoandrographolide can be used in studies related to silicosis, murine myeloid leukemia, renal tubulointerstitial fibrosis, and non-alcoholic fatty liver disease[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4176-96-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N10359. | |
| Isoastilbin | Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimers disease research[1][21][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 54081-48-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N4005. | |
| Isobavachin | Isobavachin is an orally active, blood-brain barrier-penetrating prenylated flavonoid present in Psoralea corylifolia. Isobavachin inhibits human CYP2B6, CYP2C9, CYP2C19, UGT1A1, UGT1A9, and UGT2B7. Isobavachin suppresses MAPK activation, NF-κB nuclear translocation, overexpression of iNOS/COX-2, FcεRI-mediated signaling pathways, and RANKL-induced osteoclastogenesis. Isobavachin induces autophagy, cytotoxicity, neuronal differentiation, and NRF2 activation; it alleviates oxidative damage, inflammatory responses, apoptosis, iron accumulation, mitochondrial biogenesis, and mast cell degranulation. Isobavachin is applicable to research related to liver injury, inflammatory diseases, osteoporosis, liver cancer, prostate cancer, glioma, periodontitis-induced bone loss, and Alzheimer's disease[1][2][3][4][5][6][7][8][9]. Uses: Scientific research. Category: Signaling pathways. CAS No. 31524-62-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0762. | |
| Isobutylamido thiazolyl resorcinol | Isobutylamido thiazolyl resorcinol is a selective hTyr inhibitor with an IC50 of 1.1? μM. Isobutylamido thiazolyl resorcinol shows an IC50 of 108? μM against mushroom Tyrosinase. Isobutylamido thiazolyl resorcinol effectively prevents pigmentation caused by UVB irradiation. Isobutylamido thiazolyl resorcinol significantly improves the visibility of acne-induced hyperpigmentation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1428450-95-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W251181. | |
| Isobutyl-deoxynyboquinone | Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IB-DNQ. CAS No. 1430798-22-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-125027. | |
| Isobutylshikonin | Isobutylshikonin is a kind of shikonin pigments found in hairy root culture of Lithospermum canescens. Isobutylshikonin decreases cell viability induces marked changes in JA-4 cells with nuclear condensation and swelling in the presence of LPS (HY-D1056)[1]. Uses: Scientific research. Category: Natural products. CAS No. 52438-12-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-N2592. | |
| Isocannflavin B | Isocannflavin B (Caflanone) is a flavonoid compound. Isocannflavin B exhibits anti-tumor and anti-viral activities. Isocannflavin B induces apoptosis, autophagy and cell cycle arrest in tumor cells, and inhibits cell proliferation. Isocannflavin B inhibits HCoV-OC43. Isocannflavin B can be used in research related to cancer and COVID-19[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Caflanone; FBL-03G. CAS No. 199167-23-2. Pack Sizes: 500 μg. Product ID: HY-N12677. | |
| Isochenodeoxycholic acid | Isochenodeoxycholic acid (isoCDCA) is a FXR agonist. Isochenodeoxycholic acid activates the activity of FXR and induces the mRNA expression of FXR target genes (Ostβ and Kng1). Isochenodeoxycholic acid serves as a substrate for the liver class I ADH γγ isozyme-mediated 3β-dehydrogenation reaction[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: isoCDCA. CAS No. 566-24-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N4067. | |
| Isochlorogenic acid A | Isochlorogenic acid A (3,5-Dicaffeoylquinic acid) is a natural phenolic acid with anti-mutagenicity, anti-HBV, anti-HIV, anti-oxidant, anti-bacterial, and anti-inflammatoryy activities[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3,5-Dicaffeoylquinic acid; 3,5-CQA. CAS No. 2450-53-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0056. | |
| Isocitric acid | Isocitric acid is an endogenous metabolite present in Saliva and Cellular_Cytoplasm that can be used for the research of Alzheimer's Disease, Lewy Body Dementia and Anoxia[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 320-77-4. Pack Sizes: 10 mM * 1 mL in Water; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113228. | |
| Isocorydine | Isocorydine is isolated from Dicranostigma leptopodum (Maxim.) Fedde (DLF). Isocorydine combines with Doxorubicin (DOX) has a promising potential to eradicate hepatocellular carcinoma (HCC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 475-67-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 20 mg. Product ID: HY-N2591. | |
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