MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Imatinib-d8 | Imatinib-d8 is a deuterium labeled Imatinib (STI571). Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: STI571-d8; CGP-57148B-d8. CAS No. 1092942-82-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-15463S. |  |
| Imatinib Mesylate | Imatinib Mesylate (STI571 Mesylate) is an orally active tyrosine kinases inhibitor that inhibits c-Kit, Bcr-Abl, and PDGFR (IC50=100 nM) tyrosine kinases. Uses: Scientific research. Category: Signaling pathways. Alternative Names: STI571 Mesylate; CGP-57148B Mesylate. CAS No. 220127-57-1. Pack Sizes: 10 mM * 1 mL in DMSO; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-50946. | |
| Imazapic | Imazapic is a selective herbicide used to control perennial grasses and some broadleaf weeds. Uses: Scientific research. Category: Signaling pathways. CAS No. 104098-48-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B1860. | |
| IMD-0354 | IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity[1]. IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2 uM[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IKK2 Inhibitor V. CAS No. 978-62-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10172. | |
| IMD-0560 | IMD-0560 is a novel IκB kinase β inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 439144-66-8. Pack Sizes: 10 mM * 1 mL in Ethanol; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105661. | |
| Imdevimab | Imdevimab (REGN10987) is a human monoclonal antibody that targets SARS-CoV-2 virus. Imdevimab can be used in combination with Casirivimab (HY-P99341) to reduce viral load and transiently increases anti-receptor-binding domain IgG titers. Imdevimab maintains most of its neutralization activity against viruses with B.1.1.7, B.1.351 and mink cluster 5 spike proteins[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REGN10987. CAS No. 2415933-40-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99342. | |
| iMDK | iMDK is a potent PI3K inhibitor and inhibits the growth factor MDK (also known as midkine or MK). iMDK suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 881970-80-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110171. | |
| Imeglimin hydrochloride | Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EMD 387008 hydrochloride. CAS No. 775351-61-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14771A. | |
| Imeroprubart | HY-P990999 is an FCGRT-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096)[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: IMVT-1402. CAS No. 2919582-96-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990999. | |
| Imetelstat | Imetelstat (GRN163L) is a 13-mer oligonucleotide and competitive Telomerase inhibitor. Imetelstat binds with high affinity to the template region of the RNA component of human telomerase. Imetelstat induces Apoptosis. Imetelstat is capable of selectively eliminating myelofibrosis hematopoietic stem cells. Imetelstat leads to the loss of a cancer cell's ability to maintain telomere length, resulting in the inhibition of cell proliferation[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GRN163L. CAS No. 868169-64-6. Pack Sizes: 1 mg; 2 mg. Product ID: HY-12854. | |
| Imgatuzumab | Imgatuzumab (RG 7160) is a humanized monoclonal antibody against the EGFR. Imgatuzumab acts as an immunomodulator. Imgatuzumab can be used in research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RG 7160; RO 5083945; Anti-EGFR Recombinant Antibody. CAS No. 959963-46-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99295. | |
| Im-GDP | Im-GDP is a monomeric raw material that can be used for nucleic acid synthesis. Uses: Scientific research. Category: Signaling pathways. CAS No. 1199264-75-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-178680. | |
| Imidacloprid | Imidacloprid is an effective and widely used neonicotinoid pesticide to control pests of cereals, vegetables, tea and cotton. Uses: Scientific research. Category: Signaling pathways. CAS No. 138261-41-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg. Product ID: HY-B0838. | |
| Imidacloprid-d4 | Imidacloprid-d4 is the deuterium labeled Imidacloprid[1]. Imidacloprid is an effective and widely used neonicotinoid pesticide to control pests of cereals, vegetables, tea and cotton[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1015855-75-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0838S. | |
| Imidaprilate | Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6366A; Imidaprilat. CAS No. 89371-44-8. Pack Sizes: 1 mg. Product ID: HY-109592. | |
| Imidazole | Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimers disease, gout, COVID-19 and thrombo-embolic disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene. CAS No. 288-32-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g; 50 g; 100 g; 500 g. Product ID: HY-D0837. | |
| Imidazole-5-propionic acid | Imidazole-5-propionic acid (Imidazolepropionic acid) is a urinary metabolite of L-histidine (HY-N0832). Imidazole-5-propionic acid can be used in the research of intestinal diseases and cardiovascular diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Imidazolepropionic acid. CAS No. 1074-59-5. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-W045271. | |
| Imidazoleacetic acid | Imidazoleacetic acid (Imidazolyl-4-acetic acid) is a blood-brain barrier-permeable full agonist of the GABAA receptor. Imidazoleacetic acid forms via histamine oxidation in the mouse brain. Imidazoleacetic acid exerts multiple neurochemical and behavioral effects. Imidazoleacetic acid induces a range of centrally mediated effects, including analgesia, sedation, hypnosis, as well as reductions in blood pressure, body temperature, isolation-induced aggression and motor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Imidazolyl-4-acetic acid. CAS No. 645-65-8. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113413. | |
| Imidazole ketone erastin | Imidazole ketone erastin is a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system xc- and an activator of ferroptosis. Imidazole ketone erastin has anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IKE. CAS No. 1801530-11-9. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114481. | |
| Imiloxan hydrochloride | Imiloxan (RS 21361) hydrochloride is a potent and selective alpha 2B-adrenoceptor antagonist. Imiloxan hydrochloride produces a dose-related reversal of Guanoxabenz (HY-U00123)-induced maximal mydriasis in male rats. Imiloxan hydrochloride has the potential for acute kidney injury research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RS 21361. CAS No. 81167-22-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101337A. | |
| Imipenem | Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Formimidoyl thienamycin; MK0787. CAS No. 64221-86-9. Pack Sizes: 10 mM * 1 mL in Water; 25 mg; 50 mg; 100 mg. Product ID: HY-B1369A. | |
| Imipenem monohydrate | Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Formimidoyl thienamycin monohydrate; MK0787 monohydrate. CAS No. 74431-23-5. Pack Sizes: 25 mg; 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B1369. | |
| Imipenem monohydrate (Standard) | Imipenem (monohydrate) (Standard) is the analytical standard of Imipenem (monohydrate). This product is intended for research and analytical applications. Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Formimidoyl thienamycin monohydrate (Standard); MK0787 monohydrate (Standard). CAS No. 74431-23-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B1369R. | |
| Imipramine | Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 50-49-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1490A. | |
| Imipramine hydrochloride | Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 113-52-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B1490. | |
| Imiquimod | Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: R 837. CAS No. 99011-02-6. Pack Sizes: 100 mg; 200 mg; 500 mg. Product ID: HY-B0180. | |
| Imiquimod hydrochloride | Imiquimod hydrochloride (R 837 hydrochloride), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod hydrochloride exhibits antiviral and antitumor effects in vivo. Imiquimod hydrochloride can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: R 837 hydrochloride. CAS No. 99011-78-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg. Product ID: HY-B0180A. | |
| Imirestat | Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AL 1576; Alcon 1576; HOE 843. CAS No. 89391-50-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-16255. | |
| Imisopasem manganese | Imisopasem manganese (M40403) is a stable non-peptidyl mimetic of manganese superoxide MnSOD. Uses: Scientific research. Category: Signaling pathways. Alternative Names: M40403; GC4403. CAS No. 218791-21-0. Pack Sizes: 10 mM * 1 mL in Water; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13336. | |
| Imlunestrant | Imlunestrant (LY-3484356) is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY-3484356. CAS No. 2408840-26-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-145572. | |
| Imlunestrant tosylate | Imlunestrant (LY-3484356) tosylate is an orally active, potent and selective estrogen receptor degrader (SERD) with pure antagonistic properties. Imlunestrant tosylate results in sustained inhibition of ER-dependent gene transcription and cell growth. Imlunestrant tosylate can be used for the research of ER-positive (ER+) advanced breast cancer (aBC) and endometrial endometrioid cancer (EEC)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY-3484356 tosylate. CAS No. 2408840-41-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-145572A. | |
| Im-m7GDP sodium | Im-m7GDP sodium is the cap reagent that can be used for nucleic acid synthesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 240137-51-3. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-178674A. | |
| Immunoproteasome activator 1 | Immunoproteasome activator 1 (compound A) is a selective immunoproteasome activator that increases the presentation of individual MHC-I-bound peptides by over 100-fold. Immunoproteasome activator 1 binds to the proteasome structural subunit PSMA1 and promotes the association of the proteasome activator PA28α/β (PSME1/PSME2) with immunoproteasomes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 901728-48-1. Pack Sizes: 1 mg. Product ID: HY-162965. | |
| Imneskibart | Imneskibart (AU-007) is a human monoclonal antibody that binds to the CD25-binding epitope of interleukin-2 (IL-2), blocking the binding of IL-2 to the trimeric IL-2 receptor while retaining the ability to bind to the dimeric IL-2 receptor. Imneskibart expands effector T cell and NK cell populations, reduces regulatory T cells, increases the effector T cell/regulatory T cell ratio, and alleviates vascular leakage. Imneskibart can be used in research related to melanoma and non-small cell lung cancer. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AU-007; BD-8; BDG8. CAS No. 2919583-43-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991000. | |
| Imofinostat | Imofinostat (ABT-301; MPT0E028) is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively. Imofinostat has a weak inhibitory effect on HDAC8 (IC50 of 2.5 ??μM), but no inhibitory effect on HDAC4 (IC50>10 μM). Imofinostat reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. Imofinostat has a broad-spectrum antitumor activity, including colorectal cancer, B-cell lymphoma, non-small cell lung carcinoma (NSCLC), and pancreatic cancer, while also showing therapeutic potential in non-tumor diseases like emphysema and pulmonary fibrosis[1][2][3][14][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-301; MPT0E028; TMU-C-0012. CAS No. 1338320-94-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124295. | |
| IMP-1088 | IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a Kd of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2059148-82-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112258. | |
| IMP-1710 | IMP-1710 is a potent and selective deubiquitylating enzyme UCHL1 inhibitor with an IC50 value of 38 nM. IMP-1710 has antifibrotic activity. IMP-1710 is a UCHL1 probe to identify and quantify target proteins in intact human cells[1]. IMP-1710 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. IMP-1710 can be used in the research of idiopathic pulmonary fibrosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2383117-96-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-138995. | |
| IMP2-IN-1 | IMP2-IN-1 (compound 4) is a potent IMP2 inhibitor with IC50 value of 81.3~127.5 for IMP2 RNA sequence. IMP2-IN-1 reduces IMP2 in SW480 cells. IMP2-IN-1 significantly reduces the viability of both differentiated and non-differentiated Huh7 cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1480482-51-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146178. | |
| Imperatorin | Imperatorin is an effective of NO synthesis inhibitor (IC50=9.2 μmol), which also is a BChE inhibitor (IC50=31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC50 of 12.6±3.2 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ammidin. CAS No. 482-44-0. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-N0285. | |
| Importazole | Importazole is a small molecule inhibitor of the nuclear transport receptor importin-β. Uses: Scientific research. Category: Signaling pathways. CAS No. 662163-81-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-101091. | |
| iMQT_020 | iMQT_020 is a selective allosteric SLC1A5_var inhibitor. iMQT_020 disrupts the trimeric assembly of SLC1A5_var, causing metabolic crisis in cancer cells and selectively suppressing their growth. iMQT_020 reduces glutamine anaplerosis and oxidative phosphorylation, resulting in a broad disruption of cancer metabolism. iMQT_020 reduces GSH levels and increases cellular ROS and mitochondrial ROS. iMQT_020 induces apoptosis and ferroptosis. iMQT_020 can epigenetically upregulate PD-L1 expression. iMQT_020 can be used for the study of pancreatic cancer, lung cancer, and colon cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2463893-46-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-179557. | |
| IMR-1 | IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 310456-65-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100431. | |
| IMR-1A | IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 331862-41-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100431A. | |
| Imsidolimab | Imsidolimab (ANB 019) is a high-affinity, humanized monoclonal antibody of anti-IL-36R. Imsidolimab antagonizes IL-36 cytokine signal transduction. Imsidolimab has potential application in generalized pustular psoriasis (GPP) and other inflammatory skin diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ANB 019. CAS No. 2102543-86-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99659. | |
| IMT1 | IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2304621-31-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134539. | |
| IMT1B | IMT1B (LDC203974) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. IMT1B has anti-tumour effects[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LDC203974. CAS No. 2304621-06-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-137067. | |
| Imzokitug | HY-P991001 is an CKR-L1-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001)[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: BMS-986340; CCR8.50. CAS No. 2883771-61-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991001. | |
| Inarigivir ammonium | Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium acts as a RIG-I (Retinoic acid-inducible gene-I) agonist to activate cellular innate immune responses[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ORI-9020 ammonium; SB-9000 ammonium. CAS No. 2172788-92-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101954A. | |
| Inarigivir soproxil | Inarigivir soproxil (SB9200) is an agonist of innate immunity and shows potent antiviral activity against resistant HCV variants, with EC50s of 2.2 and 1.0 μM for HCV 1a/1b in cells of genotype 1 HCV replicon systems. Inarigivir soproxil, an orally bioavailable proagent of SB 9000, has broad-spectrum antiviral activity against RNA viruses including HCV, norovirus, respiratory syncytial virus and influenza and HBV[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SB9200; GS-9992. CAS No. 942123-43-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109035. | |
| Inauhzin | Inauhzin is a dual SirT1/IMPDH2 inhibitor, and acts as an activator p53, used in the research of cancer. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INZ. CAS No. 309271-94-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15869. | |
| Inavolisib | Inavolisib (GDC-0077) is a potent, orally active, and selective PI3Kα inhibitor (IC50=0.038 nM). Inavolisib exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. Inavolisib is more selective for mutant versus wild-type PI3Kα. Inavolisib can be used for the study of breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDC-0077; RG6114. CAS No. 2060571-02-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101562. | |
| Inaxaplin | Inaxaplin (VX-147) is an orally active apolipoprotein L1 (APOL1) function inhibitor (WO2020131807, compound 2). Inaxaplin can be used for the research of kidney disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VX-147. CAS No. 2446816-88-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132820. | |
| Inbakicept | Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2135939-52-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99661. | |
| INCA-6 | INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 specifically blocks targeting of NFAT(P) substrate to the calcineurin (CN) phosphatase site and is an effective inhibitor of CN-NFAT signaling[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Triptycene-1,4-quinone. CAS No. 3519-82-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-108544. | |
| INCB054329 | INCB054329 is a potent BET inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 1628607-64-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112504. | |
| INCB-057643 | INCB-057643 is a novel, orally bioavailable BET inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 1820889-23-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111485. | |
| INCB059872 | INCB059872 is a potent, orally active, selective and irreversible Lysine-Specific Demethylase 1 (LSD1) inhibitor that achieves inhibitory activity through the formation of covalent FAD-adducts. INCB059872 can inhibit cell proliferation and induce cell differentiation by upregulating the expression of myeloid differentiation markers CD86 and CD11b. INCB059872 can be used for the research of myeloid leukemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1802909-49-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-141677. | |
| INCB086550 | INCB086550 is a potent, oral, small-molecule PD-L1 inhibitor with IC50s value of 3.1, 4.9 and 1.9 nM for human, cynomolgus, and rat, respectively. INCB086550 promotes the dimerization of cell-surface PD-L1 and induces PD-L1 entry into Golgi vesicles then traffick to the nucleus. INCB086550 can be used for multiple cancers research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PD-1/PD-L1-IN-8. CAS No. 2230911-59-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134884. | |
| INCB13739 | INCB13739 is an orally active, potent, selective and tissue-specific11β-HSD1 (11β-hydroxysteroid dehydrogenase 1) inhibitor, with IC50 values of 3.2 nM (11β-HSD1 enzymatic) and 1.1 nM (11β-HSD1 PBMC), respectively. INCB13739 can be used for type 2 diabetes mellitus (T2DM) and obesity research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 869974-19-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150701. | |
| INCB 3284 | INCB 3284 is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 can be used in the research of acute liver failure. Uses: Scientific research. Category: Signaling pathways. CAS No. 887401-92-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15450A. | |
| INCB3344 | INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 1262238-11-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50674. | |
| INCB3619 | INCB3619 is a selective and orally active ADAM inhibitor with IC50 of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. INCB3619 has anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 791826-72-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12636. | |
| Inclacumab | Inclacumab (Anti-Human selectin P Recombinant Antibody) is a human monoclonal IgG4 antibody selectively targets P-selectin with a Kd value of 9.9 nM. Inclacumab inhibits P-selectin glycoprotein ligand 1 (PSGL-1) mimetic peptide bind with P-selectin with an IC50 value of 1.9 μg/mL and strongly inhibits cell adhesion[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-Human selectin P Recombinant Antibody. CAS No. 1256258-86-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99263. | |
| Inclisiran | Inclisiran is a double-stranded small interfering RNA (siRNA) molecule. Inclisiran inhibits the transcription of PCSK9. Inclisiran inhibits Pyroptosis, activates PPARγ, and reduces NLRP3, cleaved caspase-1, IL-1β, and IL-18. Inclisiran has anti-inflammatory, lipid-regulating and anti-atherosclerotic activities. Inclisiran can be used in researches of hyperlipidemia and cardiovascular disease (CVD)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALN-PCSsc. CAS No. 1639324-58-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132591. | |
| Incyclinide | Incyclinide (CMT-3, COL-3) is a matrix metalloproteinase (MMP) inhibitor and inhibiting angiogenesis, tumor growth and invasion, and metastasis. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CMT-3; COL-3. CAS No. 15866-90-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13648. | |
| IND24 | IND24 is a potent antiprion agent with an EC50 value of 1.27 μM. IND24 decreases abnormal, misfolded, pathogenic forms of benign normally occurring prion protein on the cell surface or inside the cell[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1426047-44-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117856. | |
| Indacaterol | Indacaterol is an orally active ultra-long-acting β2 adrenergic receptor (ADRB2) agonist. Indacaterol inhibits NF-κB activity in a β-arrestin2-dependent manner, preventing further lung damage and improving lung function in COPD (chronic obstructive pulmonary disorder). Indacaterol can also be used in cardiovascular disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 312753-06-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-14299. | |
| Indacaterol maleate | Indacaterol maleate (QAB149) is an orally active ultra-long-acting β2 adrenergic receptor (ADRB2) agonist. Indacaterol maleate inhibits NF-κB activity in a β-arrestin2-dependent manner, preventing further lung damage and improving lung function in COPD (chronic obstructive pulmonary disorder). Indacaterol maleate can also be used in cardiovascular disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: QAB149. CAS No. 753498-25-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-14299A. | |
| Indacaterol maleate (Standard) | Indacaterol (maleate) (Standard) is the analytical standard of Indacaterol (maleate). This product is intended for research and analytical applications. Indacaterol maleate (QAB149) is an orally active ultra-long-acting β2 adrenergic receptor (ADRB2) agonist. Indacaterol maleate inhibits NF-κB activity in a β-arrestin2-dependent manner, preventing further lung damage and improving lung function in COPD (chronic obstructive pulmonary disorder). Indacaterol maleate can also be used in cardiovascular disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: QAB149 (Standard). CAS No. 753498-25-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14299AR. | |
| Indapamide | Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy[1][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 26807-65-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0259. | |
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