MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| HC-056456 | HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na+]i rise is slowed by HC-056456 (IC50~3 μM). Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide. CAS No. 7733-96-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112729. |  |
| HC-067047 | HC-067047 is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 883031-03-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100208. | |
| HC-070 | HC-070 is an antagonist of TRPC4/TRPC5, with IC50s of 9.3 nM and 46 nM for hTRPC5 and hTRPC4 in cells, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1628291-95-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112302. | |
| HC-5404-Fu | HC-5404-Fu is an orally active PERK inhibitor with an IC50 of 0.001 μM against human PERK. HC-5404-Fu blocks PERK activation induced by VEGFR-TKI and disrupts the adaptive stress response triggered by VEGFR-TKI. HC-5404-Fu enhances anti-angiogenic effects by inhibiting newly formed and mature tumor blood vessels in renal cell carcinoma models. HC-5404-Fu can be used in research related to renal cell carcinoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3034479-99-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157231A. | |
| HC-7366 | HC-7366 (GCN2 modulator-1) is an orally effective GCN2 activator. HC-7366 can effectively compete and occupy the ATP binding pocket of GCN2, with its IC50 being 72 nM. This binding triggers the conformational activation of GCN2, leading to the upregulation of downstream signals (such as ATF4, ASNS) in the integrated stress response (ISR) pathway, ultimately exerting anti-tumor effects. HC-7366 also has inhibitory activity against ZAK, with its IC50 being 47 nM. HC-7366 can be used for research on fibrosarcoma and acute myeloid leukemia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GCN2 modulator-1. CAS No. 2803470-63-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-160196. | |
| HCAR2 agonist 1 | HCAR2 agonist 1 (Compound 9n) is a Gi protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the Gi protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6, and MCP-1). HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1066676-21-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156025. | |
| HCGRP-(8-37) | HCGRP-(8-37) (Human α-CGRP (8-37)) is a fragment of human calcitonin gene-related peptide (hCGRP) and an antagonist of the CGRP receptor, with an IC50 of 32.1 pM against the CGRP receptor. HCGRP-(8-37) blocks adenylate cyclase activation induced by CGRP receptor ligands and attenuates vascular responses triggered by CGRP. HCGRP-(8-37) reduces capsaicin-induced vasodilation in porcine nasal mucosa and superficial skin. HCGRP-(8-37) serves as a research tool to distinguish effects mediated by CGRP or calcitonin receptors, and to investigate CGRP-induced vascular effects[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Human α-CGRP (8-37). CAS No. 119911-68-1. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P1014. | |
| HCH6-1 | HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1). HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist). HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1435265-06-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101283. | |
| Hck-IN-1 | Hck-IN-1 (compound B9), a diphenylpyrazolo compound, is a selective Nef-dependent Hck inhibitor with IC50s of 2.8 μM, >20 μM for Nef:Hck complex and Hck, respectively. Hck-IN-1 is a direct and wide HIV-1 Nef antagonists with an IC50 of 100-300 nM for wild-type HIV-1 replication. Hck-IN-1 binds pocket residue Asn126 and has anti-retroviral activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1473404-51-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-125028. | |
| HCTU | HCTU is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: O-(6-Chlorobenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate. CAS No. 330645-87-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g; 50 g; 100 g; 250 g; 500 g; 1000 g. Product ID: HY-W010951. | |
| hCYP3A4 Fluorogenic substrate 1 | hCYP3A4 Fluorogenic substrate 1 is a potrnt hCYP3A4 fluorogenic substrate with an Km value of 0.36 μM. hCYP3A4 Fluorogenic substrate 1 can be used for cell and in vivo imaging[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 186299-00-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155002. | |
| HDAC11-IN-2 | HDAC11-IN-2 (compound B6) is a high selective Histone Deacetylase 11 (HDAC11) inhibitor. HDAC11-IN-2 inhibits HDAC11 and HDAC8 with IC50s of 51.1 ×10-3 μM and 5 μM, respectively. HDAC11-IN-2 inhibits denovolipogenesis (DNL) and promotes fatty acid oxidation, thus mitigating hepaticlipid accumulation and pathological symptoms in MASLD mice. HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at Thr172 through the inhibition of HDAC11, consequently modulating DNL and fatty acid oxidation in the liver[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2919766-97-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172157. | |
| HDAC11-IN-3 | HDAC11-IN-3 (Compound A9) is a selective HDAC11 inhibitor (IC50: 4.1 nM). HDAC11-IN-3 has inhibitory effects on U937 and OCI-AML2 acute myeloid leukemia (AML) cell lines (IC50: 10 μM). HDAC11-IN-3 has significant anti-AML activity, inducing apoptosis, cell cycle arrest, and differentiation. HDAC11-IN-3 upregulates the iron transporters transferrin (TF) and transferrin receptor (TFRC), and activates the p62-Keap1-Nrf2-HMOX1 pathway, which together lead to increased intracellular iron levels and induce ferroptosis in AML cells. HDAC11-IN-3 can be used alone or in combination with Cytarabine (HY-13605) for AML research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2989934-63-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173444. | |
| HDAC2-IN-2 | HDAC2-IN-2 (compound 124) is an inhibitor of HDAC2 with Kd value of 0.1-1 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 332169-78-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-164050. | |
| HDAC6 degrader-3 | HDAC6 degrader-3 is a potent and selective HDAC6 degrader via ternary complex formation and the ubiquitin-proteasome pathway with a DC50 value of 19.4 nM. HDAC6 degrader-3 has IC50s of 4.54 nM and 0.647 μM for HDAC6 and HDAC1, respectively. HDAC6 degrader-3 causes strong hyperacetylation of α-tubulin[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2785404-83-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-152134. | |
| HDAC6-IN-33 | HDAC6-IN-33 (compound 6) is a selective and irreversible HDAC6 inhibitor with an IC50 of 193 nM. HDAC6-IN-33 shows no activity against HDAC1-4. HDAC6-IN-33 is a tight-binding HDAC6 inhibitor capable of inhibiting HDAC6 via a two-step slow-binding mechanism[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2444302-23-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161304. | |
| HDAC-IN-4 | HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor with pIC50s of 7.2 and 6.8 in BRET assay, respectively. Antitumoral activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1252003-13-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128763. | |
| HDAC-IN-87 | HDAC-IN-87 (Compound XII6) is a nonselective HDAC inhibitor, with pIC50 of 6.9 (HDAC4) and 5.8 (HDAC6) respectively. HDAC-IN-87 has fungicidal activity against P. sorghi and P. pachyrhizi. HDAC-IN-87 shows an acute oral LD50 of greater than 500 mg/kg in male and female rats[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3039482-69-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-173053. | |
| HDACs/mTOR Inhibitor 1 | HDACs/mTOR Inhibitor 1 is a dual HDACs and mTOR inhibitor, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM for HDAC1, HDAC6, mTOR, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induces tumor cell apoptosis with low toxicity in vivo. HDACs/mTOR Inhibitor 1 can be used in the research of hematologic malignancies[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2271413-06-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-114414. | |
| H-D-Phe-Pip-Arg-pNA acetate | H-D-Phe-Pip-Arg-pNA (S-2238) acetate, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA acetate is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA acetate is sensitive, accurate, and easy to perform[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-2238 acetate. CAS No. 115388-96-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-123275B. | |
| H-D-Phe-Pip-Arg-pNA hydrochloride | H-D-Phe-Pip-Arg-pNA (S-2238) hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA hydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA hydrochloride is sensitive, accurate, and easy to perform[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-2238 hydrochloride. CAS No. 160192-34-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-123275A. | |
| HD-TAC7 | HD-TAC7 is a potent PROTAC HDAC degrader with IC50 values of 3.6 μM, 4.2 μM and 1.1 μM for HDAC1, HDAC2 and HDAC3, respectively. HD-TAC7 can decreases NF-κB p65 in RAW 264.7 macrophages. HD-TAC7 can be used for the research of inflammatory diseases like asthma and chronic obstructive pulmonary disease (COPD)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2978763-95-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146346. | |
| Head activator neuropeptide | Head activator neuropeptide is a mitogen for mammalian cell lines of neuronal or neuroendocrine origin. Head activator neuropeptide signals by binding GPR37 and stimulates cells to enter mitosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 79943-68-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3840. | |
| HEAL-116 | HEAL-116 is a potent, specific and orally active 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) inhibitor with an IC50 of 1.18 μM and a KD of 1.32 μM. HEAL-116 inhibits DHEA (HY-14650) metabolism and DHEA-induced target gene expression and cell proliferation. HEAL-116 can be used for cancer research, such as prostate cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3059767-85-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175592. | |
| Heclin | Heclin is a HECT E3 ubiquitin ligases inhibitor. Heclin inhibits Smurf2, Nedd4, WWP1 (IC50 values are 6.8, 6.3, 6.9 μM) and can be used for the research of gastric cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 890605-54-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110204. | |
| Hecogenin | Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 467-55-0. Pack Sizes: 5 mg; 10 mg; 20 mg; 50 mg. Product ID: HY-N1422. | |
| Hederacoside C | Hederacoside C (Kalopanaxsaponin B) is an ingredient that can be obtained mainly from ivy leaves. Hederacoside C mediates inflammation by inhibiting activation of MAPK/NF-κB and its downstream signaling pathway. Hederacoside C has anti-inflammatory and antibacterial activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Kalopanaxsaponin B. CAS No. 14216-03-6. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-N0253. | |
| Hederagenin | Hederagenin is a triterpenoid saponin with orally active and antitumor activity. Hederagenin can inhibit the expression of iNOS, COX-2, and NF-κB in cells induced by LPS stimulation. Hederagenin also increases ROS production in cancer cells, disrupts mitochondrial membrane potential, and induces apoptosis. Hederagenin also sensitizes cancer cells to Cisplatin (HY-17394) and Paclitaxel (HY-B0015), enhancing induced apoptosis. Hederagenin can also bind to SKP2, with KD = 67.9 μM. Hederagenin also has preventive potential against alcoholic liver injury[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 465-99-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-N0256. | |
| HEI3090 | HEI3090 is a P2X7R activator. HEI3090 stimulates dendritic cells expressing P2X7R to produce IL-18, which subsequently promotes Natural Killer cells and CD4 T cells within tumors to produce IFN-γ, leading to a sustained antitumor response. HEI3090 can be used to enhance the efficacy of αPD-1 therapy in non-small cell lung cancer (NSCLC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2377167-56-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-164426. | |
| Helenalin | Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6754-13-8. Pack Sizes: 500 μg; 1 mg. Product ID: HY-119970. | |
| Helenalin acetate | Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 10180-86-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-114519. | |
| Helichrysetin | Helichrysetin is isolated from the flower Helichrysum odoratissimum. Helichrysetin is an ID2 (DNA binding inhibitor 2) inhibitor. Helichrysetin induces apoptosis. Helichrysetin has anti-tumor and antioxidant activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 62014-87-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-N4058. | |
| HEMADO | HEMADO is a potent and selective adenosine A3 receptor agonist with a Ki of 1.1 nM at the human A3 subtype[1]. HEMADO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 403842-38-6. Pack Sizes: 1 mg. Product ID: HY-103187. | |
| Hematin | Hematin, an iron-containing porphyrin, inhibits the activity of clotting factors and also fibrin clot lysis through the mechanism of binding to and inactivation of hemostatic proteins[1]. Hematin can be used for the research of acute porphyrias and cancer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 15489-90-4. Pack Sizes: 100 mg. Product ID: HY-W040030. | |
| Hematoporphyrin dihydrochloride | Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hematoporphyrin IX dihydrochloride. CAS No. 17696-69-4. Pack Sizes: 100 mg. Product ID: HY-B0754A. | |
| Hematoporphyrin monomethyl ether | Hematoporphyrin monomethyl ether, second generation of porphyrin-related photosensitizer, is characterized by its single form, high yield of singlet oxygen, high selectivity, and low toxicity, which has been widely used in the diagnosis and research of various tumors, including lung cancer, bladder cancer, and nevus flammeus and brain glioma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 148471-91-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134990. | |
| Hematoxylin | Hematoxylin (Natural Black 1), a naturally occurring flavonoid compound derived from Caesalpinia sappan Linn. Hematoxylin is a nuclear stain in histology and is also a potent Aβ42 fibrillogenesis inhibitor with an IC50 of 1.6 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Natural Black 1; Haematoxylin. CAS No. 517-28-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 1 g. Product ID: HY-N0116. | |
| Heme Oxygenase-1-IN-1 | Heme Oxygenase-1-IN-1 (compound 2) is a potent heme oxygenase 1 (HO-1) inhibitor, with an IC50 of 0.25 μM. Heme Oxygenase-1-IN-1 can be used for cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1093058-52-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111798. | |
| Heme Oxygenase-1-IN-1 hydrochloride | Heme Oxygenase-1-IN-1 (Compound 2) hydrochloride is a heme oxygenase 1 (HO-1) inhibitor with an IC50 of 0.25 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1092851-70-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111798A. | |
| Heme Oxygenase-2-IN-1 | Heme Oxygenase-2-IN-1 (Compound 9) is a potent, selective heme oxygenase-2 (HO-2) inhibitor with IC50 values of 0.9 μM and 14.9 μM against HO-2 and HO-1, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2994198-37-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147817. | |
| Hemiasterlin | Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effects. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Hemiasterlin; Milnamide B. CAS No. 157207-90-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117371. | |
| Hemicellulase | Hemicellulase is a hemicellulose-targeting hydrolase that breaks down the binding of glucose and polymers to water molecules present in plant fibers. Hemicellulase specifically degrades hemicellulose (such as xylan and mannan) in plant cell walls by hydrolyzing β-1,4-xylosidic bonds and ester bonds (such as acetyl and ferulic acid ester bonds). Hemicellulase relies on the synergistic action of the glycoside hydrolase (GH) and carbohydrate esterase (CE) families to achieve efficient hydrolysis through acid-base catalysis (such as Glu/Asp residues) and substrate binding pockets. Hemicellulase can be used in the food industry (such as improving bread texture), biofuel production (lignocellulose pretreatment) and paper industry (biobleaching)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9025-56-3. Pack Sizes: 5 g; 10 g; 25 g. Product ID: HY-P2875. | |
| Hemicholinium 3 | Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a Ki value of 25 nM. Hemicholinium 3, a neuromuscular blocking agent which inhibits the synthesis and the release of acetylcholine (ACh)[1]. Hemicholinium 3 inhibits the Epibatidine-evoked contraction and [3H]acetylcholine release with IC50s of 897 nM and 693 nM, respectively[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hemicholinium dibromide. CAS No. 312-45-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B2152. | |
| Hemin | Hemin is an iron-containing porphyrin. Hemin is an Heme oxygenase (HO)-1 inducer. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hemin chloride. CAS No. 16009-13-5. Pack Sizes: 1 g; 5 g. Product ID: HY-19424. | |
| Hemocyanin | Hemocyanin is an extracellular giant copper-containing glycoprotein. Hemocyanin can be found in the hemolymph of both mollusk and arthropod. Hemocyanin is responsible for oxygen transport. Hemocyanin is also involved in several physiological processes, such as energy storage, osmoregulation, molt cycle and exoskeleton formation. Hemocyanin in shrimp can enhance its immune response by modulating the p38 MAPK pathway. Hemocyanin from Penaeus monodon could act as an antiviral agent against a variety of viruses including DNA and RNA viruses. Hemocyanin from horseshoe crab Carcinoscorpius rotundicauda could possess a strong antimicrobial defense by the production of ROS activated with microbial proteases. Hemocyanin from L. vannamei would be effective against cervical cancer cell growth[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9013-72-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2853. | |
| Hemoglobin | Hemoglobin is a iron-containing protein in red blood cells with oxygen binding properties. Hemoglobin is an inducer of HO-1. Hemoglobin consits of heme, which binds to oxygen. Hemoglobin also transports other gases, such as carbon dioxide, nitric oxide, hydrogen sulfide and sulfide. Hemoglobin absorbs unneeded oxygen in tissues, as an antioxidant[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9008-02-0. Pack Sizes: 250 mg; 500 mg; 1 g. Product ID: HY-P2995. | |
| Hemokinin 1 (mouse) | Hemokinin 1 (mouse) is a selective agonist of neurokinin-1 receptor, with Ki of 0.175 nM and 560 nM for human NK1 receptor and human NK2 receptor, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 208041-90-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1030. | |
| Hemopressin (human, mouse) | Hemopressin is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin exerts antinociceptive action in inflammatory pain models[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1314035-51-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1091. | |
| HEMTAC CDK4/6 degrader 1 | HEMTAC CDK4/6 degrader 1 is a PROTAC connected by ligands for HSP90 and CDK4/6 with a Kd value of 35.7 μM. HEMTAC CDK4/6 degrader 1 induces CDK4/6 degradation in B16F10 melanoma cells. HEMTAC CDK4/6 degrader 1 arrests cell cycle at G0/G1 phase and induces apoptosis. HEMTAC CDK4/6 degrader 1 can be used in research of cancer[1]. HEMTAC CDK4/6 degrader 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2821803-61-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-152263. | |
| HEP-1 | HEP-1 (Human ezrin peptide (324 - 337)) is an orally active peptide with antiviral, anti-inflammatory, and immunomodulatory activities. HEP-1 is effective against infections by various viruses such as HIV, HCV, herpes viruses, HPV, and influenza viruses. As an immunomodulator, HEP-1 can enhance the adaptive immunity mediated by B cells and T cells. HEP-1 can also increase the antibody titers after hepatitis B vaccination. HEP-1 can be used in the research of viral infections and inflammation-related diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Human ezrin peptide (324-337). CAS No. 174641-44-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P10056. | |
| Heparan Sulfate | Heparan sulfate, a complex and linear polysaccharide, exists as part of glycoproteins named heparan sulfate proteoglycans, which are expressed abundantly on the cell surface and in the extracellular matrix. Uses: Scientific research. Category: Signaling pathways. CAS No. 9050-30-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-101916. | |
| Heparin | Heparin is a highly sulfated glycosaminoglycan,that is widely used as an injectable anticoagulant, and has the highest negative charge density of any known biological molecule. Heparin significantly inhibits exosome-cell interactions. Uses: Scientific research. Category: Signaling pathways. CAS No. 9005-49-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-17567. | |
| Heparinase | Heparinase (Heparinase I) degrades heparin to oligosaccharide or unsaturated disaccharide. Heparinase can be used in the preparation of low molecular weight heparin (LMWH)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Heparinase I. CAS No. 9025-39-2. Pack Sizes: 50 U; 100 U. Product ID: HY-P2839. | |
| Heparin disaccharide I-S tetrasodium | Heparin carbohydrate IS tetrasodium is the major disaccharide produced by heparinases I and II from heparin. Uses: Scientific research. Category: Signaling pathways. CAS No. 136098-10-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-141627. | |
| Heparin Lithium salt | Heparin Lithium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII). Heparin Lithium salt significantly inhibits exosome-cell interactions. Uses: Scientific research. Category: Signaling pathways. CAS No. 9045-22-1. Pack Sizes: 100 mg; 500 mg. Product ID: HY-17567B. | |
| Heparin sodium salt | Heparin sodium salt (Sodium heparin) is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa. Heparin sodium salt significantly inhibits exosome-cell interactions. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sodium heparin; Sodium heparinate. CAS No. 9041-8-1. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-17567A. | |
| Heparin sodium salt (MW 15kDa) | Heparin sodium salt (MW 15kDa) (Sodium heparin (MW 15kDa)) is a polymer of Heparin with the molecular weight of 15kDa. Heparin sodium salt is an anticoagulant which binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin factor IIa and factor Xa[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sodium heparin (MW 15kDa); Sodium heparinate (MW 15kDa). CAS No. 9041-8-1. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-17567C. | |
| Heparitin sulfate lyase | Heparitin sulfate lyase (Heparinase III) is a glycosidic lyase targeting heparan sulfate and heparin. Heparitin sulfate lyase is promising for research of low-molecular-weight heparin production and cancers[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Heparinase III. CAS No. 37290-86-1. Pack Sizes: 5 U; 10 U. Product ID: HY-P2953. | |
| Hepatitis B Virus Core (128-140) | Hepatitis B Virus Core (128-140) is a peptide of hepatitis B virus core protein. Uses: Scientific research. Category: Signaling pathways. CAS No. 160015-13-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1774. | |
| HEPBS | HEPBS is a zwitterionic buffering agent with a pH range (7.6-9.0) similar to that of biological systems. HEPBS can be used in the culture of cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 161308-36-7. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-W105704. | |
| HEPES | HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7365-45-9. Pack Sizes: 500 mg; 1 g. Product ID: HY-D0857. | |
| HEPES-d18 | HEPES-d18 is the deuterium labeled HEPES[1]. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis[2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 203805-87-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D0857S. | |
| Heptadecanoic acid-d3 | Heptadecanoic acid-d3 is the deuterium labeled Heptadecanoic acid. Heptadecanoic acid is an odd chain saturated fatty acid (OCS-FA). Heptadecanoic acid is associated with several diseases, including the incidence of coronary heart disease, prediabetes and type 2 diabetes as well as multiple sclerosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 202528-95-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W004284S. | |
| Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin | Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Trimethyl-beta-cyclodextrin. CAS No. 55216-11-0. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 1 g; 5 g. Product ID: HY-W145501. | |
| Heptelidic acid | Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic[1]. Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases[2]. Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Koningic acid. CAS No. 57710-57-3. Pack Sizes: 500 μg; 1 mg. Product ID: HY-120838. | |
| Herbacetin | Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects[1]. Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 527-95-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N0240. | |
| Herbacetin-3-sophoroside-8--glucoside | Herbacetin-3-sophoroside-8--glucoside is a natural product that can be isolated from Equisetum hyemale[1]. Uses: Scientific research. Category: Natural products. CAS No. 77298-68-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N10592. | |
| Herboxidiene | Herboxidiene (GEX1A) is a potent phytotoxic polyketide from Streptomyces sp. A7847 with a diverse range of activities, including herbicidal, anti-cholesterol, anti-tumor effects. Herboxidiene inhibits the pre-mRNA splicing process by binding to spliceosome-associated protein (SAP) 155, a subunit of SF3b, in the splicesome[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GEX1A. CAS No. 142861-00-5. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-19828. | |
| Hercynine | Hercynine (Histidine-betaine) is an intermediate (precursor) and a redox metabolite of Ergothioneine (HY-N1914), which is found in the fine leaf algae, Schizosaccharomyces cerevisiae and honey bees. Hercynine has no effect on scavenging OH radicals[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Histidine-betaine. CAS No. 534-30-5. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-W587960. | |
| Hericene A | Hericene A is an orally active aromatic hericene derivative. Hericene A exhibits anti-inflammatory and neurotrophic activities, and can found in the fruiting bodies of Hericium erinaceus. Hericene A inhibits the secretion of pro-inflammatory mediators. Hericene A promotes axonal growth, neurite branching, neurotrophic factor expression and downstream signal transduction. Hericene A can be used for the research of inflammatory and neurological diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 157207-54-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N16499. | |
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