MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Lasmotinib | Lasmotinib (PHI-101) is a FLT3 and CHK2 inhibitor. Lasmotinib potently inhibits FLT3 single activating mutations (ITD or TKD mutants) and has inhibitory activity against FLT3 double (ITD/D835Y or ITD/F691L) and triple (ITD/D835Y/F691L) resistance mutations. Lasmotinib synergizes with Venetoclax (HY-15531) or Azacytidine to inhibit leukemia. Lasmotinib exhibits anticancer activity against ovarian and breast cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PHI-101. CAS No. 2127107-15-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153857. |  |
| Lasofoxifene | Lasofoxifene (CP-336156) is an orally active and selective estrogen receptor modulator (SERM). Lasofoxifene exhibits an anti-osteoporotic function and also inhibits primary tumor growth and metastases. Lasofoxifene can be used for research of breast cancer and postmenopausal osteoporosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CP-336156. CAS No. 180916-16-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-A0037. | |
| Lasofoxifene tartrate | Lasofoxifene (CP-336156) tartrate is an orally active and selective estrogen receptor modulator (SERM)[1]. Lasofoxifene tartrate exhibits an anti-osteoporotic function and also inhibits primary tumor growth and metastases. Lasofoxifene tartrate can be used for the research of breast cancer and postmenopausal osteoporosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CP-336156 tartrate. CAS No. 190791-29-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-A0038. | |
| L-Asparaginase | L-Asparaginase (L-ASNase) is a deamidating enzyme that catalyses the hydrolysis of L-asparagine and L-glutamine, and can be used for the research of acute lymphoblastic leukemia. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L-ASNase. CAS No. 9015-68-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1923. | |
| L-Asparagine | L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Asparagine; Asn; Asparamide. CAS No. 70-47-3. Pack Sizes: 10 mM * 1 mL in Water; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-N0667. | |
| L-Asparagine-13C4,15N2,d8 | L-Asparagine-13C4,15N2,d8 is the 13C-labeled and 15N-labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1217464-18-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N0667S. | |
| L-Asparagine-13C4 monohydrate | L-Asparagine-13C4 monohydrate is the 13C-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Asparagine-13C4 monohydrate; Asn-13C4 monohydrate; Asparamide-13C4 monohydrate. CAS No. 286460-82-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N0667S3. | |
| L-Asparagine-15N2 monohydrate | L-Asparagine-15N2 monohydrate is the 15N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Asparagine-15N2 monohydrate; Asn-15N2 monohydrate; Asparamide-15N2 monohydrate. CAS No. 287484-32-6. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0667S2. | |
| L-Aspartic acid | L-Aspartic aicd is an amino acid. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 56-84-8. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-N0666. | |
| L-Aspartic acid-13C4 | L-Aspartic acid-13C4 is the 13C-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55443-54-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-N0666S4. | |
| L-Aspartic acid-15N | L-Aspartic acid-15N is the 15N-labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3715-16-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0666S3. | |
| L-Aspartic acid-d3 | L-Aspartic acid-d3 is the deuterium labeled L-Aspartic acid. L-Aspartic aicd is an amino acid that can penetrate the blood-brain barrier. L-Aspartic aicd is commonly used for preparing prodrugs to target colon and cecal tissues. L-Aspartic aicd commonly used in the study of inflammatory conditions[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3842-25-9. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0666S8. | |
| Latanoprost | Latanoprost (PHXA41) is a prostaglandin F2α analogue and can be used for glaucoma research. Latanoprost can effectively pass through cornea and be hydrolyzed by esterase to latanoprost acid. latanoprost acid is an F-prostaglandin (FP) receptor agonist, and can effectively reduce intraocular pressure (IOP) by increasing the outflow of aqueous humor through uvea[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PHXA41. CAS No. 130209-82-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0577. | |
| Latanoprost acid | Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor[1]. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 41639-83-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-113756A. | |
| Latanoprostene bunod | Latanoprostene bunod (NCX116; LBN) is a nitric oxide-releasing prostaglandin F2α analog. Latanoprostene bunod is a prodrug that, upon instillation into the eye, is hydrolyzed by corneal esterases into two active metabolites: Latanoprost (HY-B0577) and NO. Latanoprost activates the prostaglandin FP receptor to increase the outflow of aqueous humor through the uveoscleral pathway. NO increases aqueous humor drainage through the trabecular meshwork pathway, achieving synergistic enhancement targeting the dual pathways of aqueous humor outflow. Latanoprostene bunod can be used in research related to open-angle glaucoma and ocular hypertension[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NCX116; LBN. CAS No. 860005-21-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-19518. | |
| Latarcibart | Latarcibart is an anti-protein S monoclonal antibody.Latarcibart can be used for the research of bleeding disorders[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VGA-039. CAS No. 3036400-21-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991694. | |
| Lathyrol | Lathyrol is a natural product, and is used for cancer treatment. Uses: Scientific research. Category: Natural products. CAS No. 34420-19-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0561. | |
| Latikafusp | Latikafusp (AMG 256) is a bifunctional fusion protein comprising a PD-1-targeting antibody and IL-21 mutein designed to deliver IL-21 pathway stimulation to PD-1+ cells. Latikafusp is designed to prime and extend the activity of cytotoxic and memory T cells and induce anti-tumor immunity. Latikafusp has the potential for solid tumors research[1][2].Latikafusp may lead to the development of immunogenicity-mediated responses[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG 256. CAS No. 2552814-07-8. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P99687. | |
| Latozinemab | Latozinemab (AL001) is a recombinant human anti-Sortilin monoclonal antibody. Latozinemab effectively binds Sortilin with a high affinity and blocks the interaction between progranulin protein (PGRN) and Sortilin receptor. Latozinemab has the potential for progranulin gene (GRN) mutations causative of Frontotemporal dementia (FTD) (FTD-GRN) research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AL001. CAS No. 2376132-27-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99688. | |
| Latrunculin A | Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with Kds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LAT-A. CAS No. 76343-93-6. Pack Sizes: 100 μg (237.2 μM * 1 mL in Ethanol). Product ID: HY-16929. | |
| Latrunculin B | Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 76343-94-7. Pack Sizes: 1 mg. Product ID: HY-101848. | |
| LATS-IN-2 | LATS-IN-2 is an efficiently acting LATS (large tumor suppressor kinase) inhibitor. LATS-IN-2 shows potent inhibitory activity against LATS1 with an IC50 value of 1.3 nM. LATS-IN-2 suppresses the phosphorylation of YAP by inhibiting LATS kinase activity. LATS-IN-2 increases the thickness of the epidermis in mice. LATS-IN-2 can be used for the study of ocular diseases such as limbal stem cell deficiency and corneal endothelial dysfunction[1]. . Uses: Scientific research. Category: Signaling pathways. CAS No. 2248728-49-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-176886. | |
| Lauflumide | Lauflumide (BisfluoroModafinil) is the common alternative of modafinil. Modafinil is commonly prescribed for the research narcolepsy. Lauflumide has the potential for cognitive enhancing[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BisfluoroModafinil; CRL-40940. CAS No. 90280-13-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111178. | |
| Laurdan | Laurdan is a membrane-permeable fluorescent probe that displays spectral sensitivity to the phospholipid phase of the cell membrane to which it is bound. Quantitation of generalized polarization (GP) of Laurdan can be used to identify phospholipid phase (Ex/Em = 370/440-490 nm). Uses: Scientific research. Category: Signaling pathways. CAS No. 74515-25-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-D0080. | |
| Lauric acid | Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC50s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 143-07-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-Y0366. | |
| Lauroscholtzine | Lauroscholtzine (N-Methyllaurotetanine), a natural alkaloid, is a 5-HT1A receptor agonist[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Methyllaurotetanine. CAS No. 2169-44-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N3398. | |
| Lauroyl coenzyme A lithium | Lauroyl coenzyme A lithium salt is an intermediary in fatty acid synthesis or metabolism, formed by combining long-chain fatty acids (or lauric acid) with coenzyme A. Lauroyl coenzyme A lithium salt is involved in lipid biosynthesis and fatty acid transport, in which coenzyme A acts as a transport molecule to help move and target specific compounds. Uses: Scientific research. Category: Signaling pathways. CAS No. 190063-12-8. Pack Sizes: 1 mg. Product ID: HY-126912A. | |
| Lauroyl-L-carnitine chloride | Lauroyl-L-carnitine chloride is an orally active metabolite. Lauroyl-L-carnitine chloride significantly reverses the decrease in its target gene IL-10. Lauroyl-L-carnitine chloride alleviates Crohn' s-like colitis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6919-91-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130321. | |
| Lauroyl-L-carnitine-d9 chloride | Lauroyl-L-carnitine-d9 chloride is the deuterium labeled Lauroyl-L-carnitine chloride (HY-130321). Lauroyl-L-carnitine chloride is an orally active metabolite. Lauroyl-L-carnitine chloride significantly reverses the decrease in its target gene IL-10. Lauroyl-L-carnitine chloride alleviates Crohn' s-like colitis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2245711-25-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-130321S1. | |
| Lauroyl lysine | Lauroyl lysine (N6-Lauroyl-L-lysine) is a compound that can be synthesized by recombinant enzymes. After the synthase is cloned and expressed, it can be used to synthesize lauroyl lysine from specific raw materials with high yield. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N6-Lauroyl-L-lysine; ; N6-(1-Oxododecyl)-L-lysine. CAS No. 52315-75-0. Pack Sizes: 10 g; 25 g; 50 g; 100 g. Product ID: HY-117195. | |
| Lauroylsarcosine sodium | Lauroylsarcosine sodium is a surfactant commonly used in personal care and cosmetics such as shampoos, facial cleansers and toothpaste. It works by lowering the surface tension of water, allowing it to better penetrate and clean surfaces. Lauroylsarcosine sodium is considered safe for cosmetic use and is approved for use in several countries. However, it can cause skin irritation in high concentrations or with prolonged exposure. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sarkosyl NL sodium. CAS No. 137-16-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 25 g; 100 g. Product ID: HY-125920. | |
| Lauryl benzalkonium chloride | Lauryl benzalkonium chloride (Dimethylbenzyllaurylammonium chloride) is a cationic surfactant[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dimethylbenzyllaurylammonium chloride. CAS No. 139-07-1. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B1549. | |
| Lauryl glucoside (50% in water) | Lauryl glucoside (50% in water) is a non-ionic surfactant with high cleansing ability, high foaming ability and low cost[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 110615-47-9. Pack Sizes: 25 mL; 50 mL; 100 mL; 500 mL. Product ID: HY-W392173. | |
| Lavendustin A | Lavendustin A (RG-14355) is a potent, selective and ATP-competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 11 nM. Lavendustin A does not inhibit protein kinase A or C. Lavendustin A can suppress VEGF-induced angiogenesis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RG-14355. CAS No. 125697-92-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18963. | |
| Lawsone | Lawsone is an orally active naphthoquinone dye that can be isolated from the leaves of Lawsonia inermis. Lawsone can induce apoptosis. Lawsone has antibacterial, antitumor and antioxidant activities. Lawsone can be used in anti-tumor drug research[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 83-72-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-N2493. | |
| Lazertinib | Lazertinib (YH25448; GNS-1480) is an orally active, blood-brain barrier permeable third-generation EGFR tyrosine kinase inhibitor, as well as an ABCB1/ABCG2 inhibitor and a TRPA1 activator. Lazertinib exhibits IC50 values of 0.4 mM and 0.2 mM against human ABCB1 and ABCG2, respectively. By inhibiting mutant EGFR signaling, EGFR phosphorylation and the downstream ERK/AKT pathway, as well as upregulating surface expression of EGFR/MET, Lazertinib induces cell cycle arrest, apoptosis, spontaneous calcium responses, hyperexcitability of dorsal root ganglion (DRG) neurons, and TRPA1-dependent pain-like behaviors. Lazertinib competitively binds to the substrate-binding sites of ABCB1/ABCG2, stimulates their ATPase activity without altering their expression or plasma membrane localization, thereby enhancing ADCC activity, acting as a chemosensitizer, and reversing ABCB1-mediated multidrug resistance. It exerts antitumor activity as a single agent or in combination with other drugs. Lazertinib is applicable to research related to non-small cell lung cancer, multidrug-resistant cancers, and paresthesia[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: YH25448; GNS-1480. CAS No. 1903008-80-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-109061. | |
| Lazertinib mesylate | Lazertinib (YH25448; GNS-1480) mesylate is an orally active, blood-brain barrier permeable third-generation EGFR tyrosine kinase inhibitor, as well as an ABCB1/ABCG2 inhibitor and a TRPA1 activator. Lazertinib mesylate exhibits IC50 values of 0.4 mM and 0.2 mM against human ABCB1 and ABCG2, respectively. By inhibiting mutant EGFR signaling, EGFR phosphorylation and the downstream ERK/AKT pathway, as well as upregulating surface expression of EGFR/MET, Lazertinib mesylate induces cell cycle arrest, apoptosis, spontaneous calcium responses, hyperexcitability of dorsal root ganglion (DRG) neurons, and TRPA1-dependent pain-like behaviors. Lazertinib mesylate competitively binds to the substrate-binding sites of ABCB1/ABCG2, stimulates their ATPase activity without altering their expression or plasma membrane localization, thereby enhancing ADCC activity, acting as a chemosensitizer, and reversing ABCB1-mediated multidrug resistance. It exerts antitumor activity as a single agent or in combination with other drugs. Lazertinib mesylate is applicable to research related to non-small cell lung cancer, multidrug-resistant cancers, and paresthesia[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: YH25448 mesylate; GNS-1480 mesylate. CAS No. 2247995-37-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109061B. | |
| L-Azetidine-2-carboxylic acid | L-Azetidine-2-carboxylic acid is a proline analog. L-Azetidine-2-carboxylic acid upregulates the lipid autophagy marker LC3-II via activation of the PERK pathway. L-Azetidine-2-carboxylic acid increases pro-apoptotic BAX protein. L-Azetidine-2-carboxylic acid induces ATF6 cleavage and upregulates phosphorylated eIF2α levels. L-Azetidine-2-carboxylic acid induces ER stress, inducing protein misfolding and aggregation. L-Azetidine-2-carboxylic acid shows teratogenic, pro-inflammatory and pro-apoptotic effects[1][2][3][4][5][6][7][8][9]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2133-34-8. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g. Product ID: HY-W050044. | |
| L-Azidohomoalanine hydrochloride | L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. L-Azidohomoalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 942518-29-8. Pack Sizes: 50 mg; 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-140346A. | |
| L-Azidonorleucine hydrochloride | L-Azidonorleucine hydrochloride, an unnatural amino acid, is A Methionine surrogate. L-Azidonorleucine hydrochloride can be used to label mammalian cell proteins and identify a diverse set of methionyl-tRNA synthetase (MetRS) mutants [1][2]. L-Azidonorleucine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1454334-76-9. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-131033. | |
| LB-100 | LB-100 is a protein phosphatase 2A (PP2A) inhibitor, with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1632032-53-1. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-18597. | |
| LB244 | LB244 is a homologue of BB-Cl-amidine, which is an orally effective STING inhibitor (EC50=0.8 μM) and can be used to inhibit STING-dependent inflammatory diseases. The pharmacokinetic properties of LB244 indicate limited oral activity in mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3074622-05-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156117. | |
| L-β-Ethynylserine | L-β-ethynylserine (βES) is a threonine analog. L-β-ethynylserine is efficiently incorporated into newly synthesized proteins, and allows their selective visualization or enrichment through bioorthogonal ligation to fluorescent dyes or affinity tags, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 65207-64-9. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164745. | |
| L-Biphenylalanine | L-Biphenylalanine is a phenylalanine derivative[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: [1,1'-Biphenyl]-4-propanoic acid, α-amino-, (S)-; 4-Biphenylyl-L-alanine; 4-Phenyl-L-phenylalanine; Biphenylalanine. CAS No. 155760-02-4. Pack Sizes: 1 g; 5 g. Product ID: HY-79106. | |
| L-Buthionine-(S,R)-sulfoximine | L-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The IC50 value of L-Buthionine-(S,R)-sulfoximine on melanoma, breast and ovarian tumor specimens are 1.9 μM, 8.6 μM, and 29 μM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L-Buthionine sulfoximine; L-BSO. CAS No. 83730-53-4. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg. Product ID: HY-106376A. | |
| LC-2 | LC-2 is a potent and first-in-class von Hippel-Lindau-based PROTAC capable of degrading endogenous KRAS G12C, with DC50s between 0.25 and 0.76 μM[1]. LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2502156-03-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137516. | |
| LC3-mHTT-IN-AN1 | LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 486443-73-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130258. | |
| L-Canaline | L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. L-Canaline has anticancer and antiproliferative effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 496-93-5. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg. Product ID: HY-129476. | |
| L-Canavanine | L-Canavanine is aamino acids and their derivatives. Uses: Scientific research. Category: Signaling pathways. CAS No. 543-38-4. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-B1581. | |
| L-Canavanine sulfate | L-Canavanine sulfate is a selective inhibitor of inducible NO synthase. Uses: Scientific research. Category: Signaling pathways. CAS No. 2219-31-0. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg. Product ID: HY-B1581A. | |
| L-Carnitine | L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-Carnitine; Levocarnitine. CAS No. 541-15-1. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 5 g; 10 g; 25 g; 50 g. Product ID: HY-B0399. | |
| L-Carnitine-d3 hydrochloride | L-Carnitine-d3 (hydrochloride) is the deuterium labeled L-Carnitine hydrochloride[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-Carnitine-d3 hydrochloride; Levocarnitine-d3 hydrochloride. CAS No. 350818-62-1. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg. Product ID: HY-B1453S. | |
| L-Carnitine hydrochloride | L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-Carnitine hydrochloride; Levocarnitine hydrochloride. CAS No. 6645-46-1. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-B2246. | |
| L-Carnitine(mono)-O-glutaryl-d3 perchlorate | L-Carnitine(mono)-O-glutaryl-d3 (perchlorate) is the deuterium labeled L-Carnitine(mono)-O-glutaryl (perchlorate)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2245711-21-9. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-144084S. | |
| L-Carnitine (Standard) | L-Carnitine (Standard) is the analytical standard of L-Carnitine. This product is intended for research and analytical applications. L-Carnitine ((R)-Carnitine), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine is an antioxidant. L-Carnitine can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-Carnitine (Standard); Levocarnitine (Standard). CAS No. 541-15-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0399R. | |
| L-Carnosine | L-Carnosine is a dipeptide composed of beta-alanine and histidine. L-Carnosine is an endogenous metabolite found in human brain, muscle and gastrointestinal tissues and is present in all vertebrates. L-Carnosine is a non-enzymatic free radical scavenger and natural antioxidant with anti-inflammatory and neuroprotective properties that can inhibit biochemical changes associated with aging[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 305-84-0. Pack Sizes: 10 mM * 1 mL in Water; 100 mg. Product ID: HY-W013494. | |
| L-Carnosine (Standard) | L-Carnosine (Standard) is the analytical standard of L-Carnosine. This product is intended for research and analytical applications. L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging.In Vitro: L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging[1]. L-Carnosine also exhibits some antioxidant effects. The antioxidant mechanism of L-Carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, and ROS and free radicals scavenging ability[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 305-84-0. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W013494R. | |
| LCC-12 formic | LCC-12 formic is a dimer of metformin that targets mitochondrial copper(II), leading to a decrease in the NAD(H) pool and modulation of inflammatory responses. LCC-12 formic reduces inflammation in mouse models of bacterial and viral infections. LCC-12 formic also serves as a tool for investigating metabolic diseases through its effects on cell plasticity and epigenetic programming. Uses: Scientific research. Category: Signaling pathways. CAS No. 3029253-76-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-167935. | |
| L-Chicoric Acid | L-Chicoric Acid ((-)-Chicoric acid) is a dicaffeoyltartaric acid and a potent, selective and reversible HIV-1 integrase inhibitor with an IC50 of ~100 nM. L-Chicoric Acid inhibits HIV-1 replication in tissue culture[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Chicoric acid; trans-Caffeoyltartaric acid. CAS No. 70831-56-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N0457A. | |
| L-Citrulline | L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway. Uses: Scientific research. Category: Signaling pathways. CAS No. 372-75-8. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g. Product ID: HY-N0391. | |
| L-Citrulline-d4 | L-Citrulline-d4 is the deuterium labeled L-Citrulline. L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway. Uses: Scientific research. Category: Signaling pathways. CAS No. 1217474-00-4. Pack Sizes: 1 mg. Product ID: HY-N0391S4. | |
| L-Citrulline-d7 | L-Citrulline-d7 is the deuterium labeled L-Citrulline. L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway. Uses: Scientific research. Category: Signaling pathways. CAS No. 2483831-24-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N0391S5. | |
| L-Citrulline DL-malate | L-Citrulline (DL-malate) is an organic compound commonly used as a nutritional supplement. It boosts the body's production of nitrogen oxides, improves circulation and athletic performance, and reduces muscle fatigue. In addition, L-Citrulline DL-malate also plays an important role in some industrial fields, for example, it is used in the field of agriculture to enhance plant immunity. Uses: Scientific research. Category: Signaling pathways. CAS No. 70796-17-7. Pack Sizes: 10 mM * 1 mL in Water; 1 g; 5 g. Product ID: HY-N0391A. | |
| Lck-IN-5 | Lck-IN-5 (example C10) is a potent and selective lymphocyte-specific protein tyrosine kinase (LCK) inhibitor. Lck-IN-5 selectively disrupts the interaction between the SH3 domain of LCK and the RK motif of CD3ε, thereby impairing LCK recruitment to the TCR. Lck-IN-5 modulates the activity of CD3ε-containing CAR and TRuC T cells, attenuating cytokine production and promoting a central-memory-like phenotype associated with enhanced persistence. Lck-IN-5 can be used for autoimmune diseases and graft-versus-host disease research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1356734-45-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-180888. | |
| Lck Inhibitor | Lck Inhibitor is a potent, orally active Lck (lymphocyte specific kinase) inhibitor with IC50s of 7, 2.1, 4.2 and 200 nM for Lck, Lyn, Src and Syk kinases, respectively. Lck Inhibitor shows >1000-fold selectivity for Lck over MAPK, CDK and RSK family representatives. Lck Inhibitor inhibits T cell proliferation and in vivo models of arthritis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 847950-09-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12072. | |
| LCKLSL | LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 533902-29-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2333. | |
| LCL161 | LCL161 is a IAP inhibitor which inhibits XIAP in HEK293 cell and cIAP1 in MDA-MB-231 cell with IC50s of 35 and 0.4 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1005342-46-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15518. | |
| LCL521 | LCL521 is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1226851-11-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103593. | |
| LC-MB12 | LC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC50 of 11.8 nM. LC-MB12 contains BGJ398 (a FGFR2 inhibitor), PROTAC linker and CRBN.LC-MB12 inhibits FGFR2 signaling in gastric cancer cells and has anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2828438-38-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149843. | |
| LCMV gp33-41 | LCMV gp33-41, the carboxyl-extended 9-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LCMV GP(33-41) M-peptide; gp33 epitope. CAS No. 151705-84-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1569. | |
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