MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| POPG sodium salt | POPG sodium salt is a negatively charged phospholipid. POPG sodium salt affects the interactions of membrane proteins with other molecules by changing the charge characteristics of the lipid environment. POPG sodium salt increases the apparent affinity of Gαq and Gβ1γ1 for activated NTS1. POPG sodium salt can interact with the positive charge of peptides. POPG sodium salt can be used in Parkinson's disease research[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PG(16:0/18:1); 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho-(1'-rac-glycerol). CAS No. 268550-95-4. Pack Sizes: 10 mM * 1 mL in Ethanol; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130463. |  |
| Porcine dynorphin A(1-13) | Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Dynorphin A Porcine Fragment 1-13. CAS No. 72957-38-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0088. | |
| Porcine skin Gelatin,suitable for cell culture(medium gel strength) | Porcine skin Gelatin, suitable for cell culture (medium gel strength) can be used to coat cells to improve cell attachment[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9000-70-8. Pack Sizes: 100 g; 500 g. Product ID: HY-Y1365E. | |
| Poricoic acid A | Poricoic acid A can be isolated from Poria cocos. Poricoic acid A is an orally active anti-tumor agent. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis. Poricoic acid A also attenuatea fibroblast activation and abnormal extracellular matrix remodeling in renal fibrosis by activating AMPK and inhibiting Smad3. Poricoic acid A significantly reduces the magnitude of rise in serum creatinine and urea levels in rat model when combined with Melatonin. Poricoic acid A ameliorates renal fibrosis and podocyte injury by attenuating oxidative stress and inflammation through regulating NF-κB and Nrf2 in IRI rodent model in combination with Melatonin[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Poricoic acid A(F). CAS No. 137551-38-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2995. | |
| Poricoic acid B | Poricoic acid B is a triterpenoid compound that can be isolated from Poria cocos. Poricoic acid B inhibits intracellular lipid accumulation and reduces the levels of hepatocyte injury markers. Poricoic acid B inhibits the production of NO, TNF-α, IL-1β and IL-6, thereby exerting anti-inflammatory activity. Poricoic acid B can be used in the research of metabolic dysfunction-associated fatty liver disease and inflammatory diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 137551-39-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N4124. | |
| Posaconazole | Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SCH 56592. CAS No. 171228-49-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17373. | |
| Posaconazole-d4 | Posaconazole-d4 is a deuterium-labeled form of Posaconazole. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SCH 56592-d4. CAS No. 1133712-26-1. Pack Sizes: 1 mg. Product ID: HY-17373S1. | |
| Posdinemab | Posdinemab (JNJ-63733657) is a humanized IgG1/κ monoclonal antibody that selectively targets phosphorylated tau (pT217). Posdinemab specifically binds to the pT217+tau epitope rich in the proline domain, blocks tau protein aggregation and seed propagation, and promotes the clearance of extracellular tau species. Posdinemab reduces the levels of free and total p217+tau in cerebrospinal fluid, thereby inhibiting the pathological propagation of tau protein and the formation of neurofibrillary tangles. Posdinemab can be used for the study of progressive supranuclear palsy syndrome and Alzheimer's disease (AD), especially for prodromal or mild AD disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ-63733657. CAS No. 2517973-04-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9995. | |
| Posenacaftor sodium | Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PTI-801 sodium. CAS No. 2095064-06-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109187A. | |
| POSH-IN-2 | POSH-IN-2 (MIDI), a mitochondrial division inhibitor, is a DRP1 inhibitor that potently blocks mitochondrial fragmentation induced by cellular stresses and genetic mitochondrial lesions. POSH-IN-2 covalently interacts with DRP1-C367 to target DRP1 interaction with multiple receptors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 348145-43-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164566. | |
| POT-4 | POT-4 (AL-78898A), a Compstatin derivative, is a potent inhibitor of complement factor C3 activation. POT-4 can be used for age-related macular degeneration research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AL-78898A. CAS No. 934461-40-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P3204. | |
| Potassium 1,2-naphthoquinone-4-sulphonate | Potassium 1,2-naphthoquinone-4-sulphonate (Compound 16) is a 6-phosphogluconate dehydrogenase (6PGDH) inhibitor with an IC50 of 53 μM. Potassium 1,2-naphthoquinone-4-sulphonate can be used in the study of human African trypanosomiasis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5908-27-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W726137. | |
| Potassium 1H-indol-3-yl sulfate-d4 | Potassium 1H-indol-3-yl sulfate-d4 potassium is the deuterium labeled Potassium 1H-indol-3-yl sulfate. Potassium 1H-indol-3-yl sulfate is a metabolite of tryptophan, produced by intestinal microorganisms and combined with sulfate in the liver before entering the circulatory system. Potassium 1H-indol-3-yl sulfate is a potent endogenous agonist of the aryl hydrocarbon receptor (AhR) and a urinary toxin. Potassium 1H-indol-3-yl sulfate can be used for research on kidney diseases. Uses: Scientific research. Category: Signaling pathways. CAS No. 1346601-03-3. Pack Sizes: 1 mg. Product ID: HY-W011910S. | |
| Potassium 1H-indol-3-yl sulfate-d5 | Potassium 1H-indol-3-yl sulfate-d5 is the deuterium labeled 3-Indoxyl Sulfate potassium. Potassium 1H-indol-3-yl sulfate is a metabolite of tryptophan, produced by intestinal microorganisms and combined with sulfate in the liver before entering the circulatory system. Potassium 1H-indol-3-yl sulfate is a potent endogenous agonist of the aryl hydrocarbon receptor (AhR) and a urinary toxin. Potassium 1H-indol-3-yl sulfate can be used for research on kidney diseases. Uses: Scientific research. Category: Signaling pathways. CAS No. 1644451-34-2. Pack Sizes: 2.5 mg. Product ID: HY-132429S. | |
| Potassium 2,3,3-trimethylindole-5-sulfonate | Potassium 2,3,3-trimethylindole-5-sulfonate (2,3,3-Trimethylindolenine-5-sulfonic acid potassium salt) is an indole derivative containing a sodium sulfonate group and is commonly used as a key intermediate in dye synthesis. Potassium 2,3,3-trimethylindole-5-sulfonate can be coupled to peptides, proteins, nucleic acids, RNA, DNA, carbohydrates, polymers, and small molecules via the sulfonyl substituent[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2,3,3-Trimethylindolenine-5-sulfonic acid potassium salt. CAS No. 184351-56-2. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-W024881. | |
| Potassium chloride, for cell culture | Potassium chloride, for cell culture is potassium chloride that can be used for cell culture. Potassium chloride, for cell culture increases extracellular potassium ion concentration to induce cellular depolarization, thereby activating voltage-gated calcium channels and regulating intracellular calcium signaling. Potassium chloride, for cell culture upregulates Brn-5. Potassium chloride, for cell culture inhibits the proliferation of neurons and some plant cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7447-40-7. Pack Sizes: 250 g; 500 g. Product ID: HY-Y0537E. | |
| Potassium dihydrogen phosphate, AR,99.5% | Potassium phosphate monobasic (DiA) is a commonly used in biological assay buffers. Potassium phosphate monobasic is moderate to highly concentrated aqueous solutions of potassium phosphate monobasic for the production of phosphate buffers and other laboratory applications[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7778-77-0. Pack Sizes: 100 g; 500 g. Product ID: HY-Y0332B. | |
| Potassium ferrocyanide trihydrate, 98.5% | Potassium ferrocyanide trihydrate, 98.5% is a biochemical reagent. Potassium ferrocyanide trihydrate, 98.5% can be used as a food additive[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Potassium hexacyanoferrate(II) trihydrate. CAS No. 14459-95-1. Pack Sizes: 10 mM * 1 mL in Water; 100 g; 500 g; 1 k g. Product ID: HY-Y0416. | |
| Potassium hydrogen phthalate | Potassium 2-carboxybenzoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. CAS No. 877-24-7. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 50 g; 100 g; 500 g; 1 k g. Product ID: HY-Y0037. | |
| Potassium osmate(VI) dihydrate,99% | Potassium osmate (VI) dihydrate,99% is a catalyst capable of catalyzing the oxygen transfer reaction between selenides and selenoxides. Potassium osmate (VI) dihydrate,99% can catalyze the conversion of unsaturated selenoxides into dihydroxyalkyl selenides via the reduction reaction of selenoxides to selenides and the dihydroxylation reaction of CNC double bonds. Potassium osmate (VI) dihydrate,99% can serve as a pre-oxidant component of AD-mix-β (HY-W089458) for oxygen transfer and unsaturated selenoxide conversion reactions under aqueous conditions[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 10022-66-9. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-Y0994A. | |
| Potassium oxonate | Potassium oxonate (Potassium azaorotate) is a uricase inhibitor that inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Potassium azaorotate; Potassium otastat; Oteracil potassium. CAS No. 2207-75-2. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 5 g; 10 g; 25 g; 50 g. Product ID: HY-17511. | |
| Potassium p-nitrophenyl sulfate | Potassium p-nitrophenyl sulfate (4-Nitophenyl Sulfate potassium) serves as a chromogenic substrate for arylsulfatases. Potassium p-nitrophenyl sulfate releases nitrophenol under the cleavage action of arylsulfatases, and the activity of arylsulfatases can be quantitatively determined via colorimetric detection at 400 nm. Potassium p-nitrophenyl sulfate is commonly used in enzyme inhibition assays and metabolite analog-related studies[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4-Nitopheyl Sulfate potassium. CAS No. 6217-68-1. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W009454. | |
| Potassium pyrosulfate | Potassium pyrosulfate (Pyrosulfuric acid, dipotassium salt) is a kind of biological materials or organic compounds that are widely used in life science research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pyrosulfuric acid, dipotassium salt. CAS No. 7790-62-7. Pack Sizes: 10 mM * 1 mL in Water; 100 g; 500 g; 1 k g. Product ID: HY-W019970. | |
| Potassium sodium tartrate | Potassium sodium tartrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. CAS No. 304-59-6. Pack Sizes: 25 g; 50 g; 100 g. Product ID: HY-ER007. | |
| Povetacicept | Povetacicept (ALPN-303) is an engineered Fc fusion protein containing the TACI domain, and acts as a dual APRIL/BAFF antagonist. The Kd value of Povetacicept for human BAFF is 59.3 pM, while its Kd value for human APRIL is 1.00 pM. Povetacicept reduces the activation, proliferation, differentiation and survival of B cells, and inhibits the production of immunoglobulins and autoantibodies. Povetacicept can be used in research related to autoimmune hemolytic anemia, immune thrombocytopenia, systemic lupus erythematosus, lupus nephritis and myasthenia gravis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALPN-303. CAS No. 2490217-42-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P990706. | |
| Povidone iodine | Povidone iodine (iodopovidone) displays excellent antibacterial activity which can against MRSA and MSSA strains with MICs of 31.25 mg/L and 7.82 mg/L, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: iodopovidone. CAS No. 25655-41-8. Pack Sizes: 5 g; 25 g. Product ID: HY-B2234. | |
| Povorcitinib | Povorcitinib (INCB54707) is a potent and selective JAK1 inhibitor that effectively reduces abscesses and inflammatory nodules. Povorcitinib is used to study cutaneous lupus erythematosus (CLE) and lichen planus (LP)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INCB54707. CAS No. 1637677-22-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145588. | |
| POVPC | POVPC is an oxidized phospholipid can be found in in oxidatively modified low density lipoprotein (oxLDL). POVPC inhibits VSMC growth in high serum condition. POVPC induces apoptosis in low serum condition[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 121324-31-0. Pack Sizes: 1 mg (8.42 mM * 200 μL in Ethanol); 5 mg (8.42 mM * 1 mL in Ethanol). Product ID: HY-130576. | |
| Pozanicline dihydrochloride | Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites[1]. Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-089 dihydrochloride. CAS No. 161416-61-1. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110160. | |
| Pozelimab | Pozelimab (REGN3918) is a fully human IgG4 anti-C5 monoclonal antibody. Pozelimab binds to C5 and C5 variants with high affinity and blocks complement-mediated hemolysis. Pozelimab can be used for the research of complement-mediated diseases[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REGN3918. CAS No. 2096328-94-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99786. | |
| Poziotinib | Poziotinib (HM781-36B) is an orally active, irreversible pan-HER inhibitor, which effectively inhibits EGFRwt, HER-2 and HER-4 with IC50s of 3.2, 5.3 and 23.5 nM, respectively. Poziotinib (HM781-36B) also shows excellent inhibitory activities against mutated EGFRs, including EGFRT790M and EGFRL858R/T790M, with IC50s of 4.2 and 2.2 nM, respectively. Excellent antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HM781-36B; NOV120101. CAS No. 1092364-38-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15730. | |
| PP1 | PP1 is a potent, and Src family-selective tyrosine kinase inhibitor with IC50 of 5 and 6 nM for Lck and Fyn, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AGL 1872; EI 275. CAS No. 172889-26-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13804. | |
| PP121 | PP121 is a multi-targeted kinase inhibitor with IC50s of 10, 60, 12, 14, 2 nM for mTOR, DNK-PK, VEGFR2, Src, PDGFR, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1092788-83-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10372. | |
| PP2 | PP2 is a reversible and ATP-competitive Src family kinases inhibitor with IC50s of 4 and 5 nM for Lck and Fyn, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AGL 1879. CAS No. 172889-27-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13805. | |
| PP 3 | PP 3 (Compound 3) is an EGFR tyrosine kinase inhibitor with an IC50 of 2.7 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5334-30-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108484. | |
| PP5-IN-1 | PP5-IN-1 is a competitive and selective serine/threonine protein phosphatase 5 (PP5) inhibitor with a Ki value of 244 nM. PP5-IN-1 induces extrinsic apoptosis (Apoptosis), disrupts the integrity of complex II, and activates Caspase 8. PP5-IN-1 can be used in research related to clear cell renal cell carcinoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1022417-69-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155374. | |
| PPACK dihydrochloride | PPACK dihydrochloride is an orally active, selective molecular glue degrader targeting IKZF2. Through a molecular glue mechanism, PPACK dihydrochloride binds to CRBN, recruits IKZF2 to form a ternary complex, and promotes its ubiquitination and proteasomal degradation. This further converts inhibitory regulatory T cells (Treg) into effector-like T cells, enhances CD8+ T cell responses, and modulates the Teff:Treg balance. PPACK dihydrochloride also increases the production of the inflammatory cytokine IL-2 and reduces the suppressive activity of Treg. PPACK dihydrochloride can be used in cancer immunotherapy research, and exhibits a synergistic effect when combined with immune checkpoint inhibitors such as anti-PD1[1][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pebac; D-Phenylalanyl-prolyl-arginyl Chloromethyl Ketone; D-Phe-Pro-Arg-CH2Cl. CAS No. 82188-90-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-122542A. | |
| PPACK II diTFA | PPACK II diTFA is an irreversible and specific glandular and plasma kallikreins inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 649748-23-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-122543. | |
| PPACK TFA | PPACK TFA is an orally active, selective molecular glue degrader targeting IKZF2. Through a molecular glue mechanism, PPACK TFA binds to CRBN, recruits IKZF2 to form a ternary complex, and promotes its ubiquitination and proteasomal degradation. This further converts inhibitory regulatory T cells (Treg) into effector-like T cells, enhances CD8+ T cell responses, and modulates the Teff:Treg balance. PPACK TFA also increases the production of the inflammatory cytokine IL-2 and reduces the suppressive activity of Treg. PPACK TFA can be used in cancer immunotherapy research, and exhibits a synergistic effect when combined with immune checkpoint inhibitors such as anti-PD1[1][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 157379-44-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122542B. | |
| PPADS tetrasodium | PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca2+ exchanger in guinea pig airway smooth muscle[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 192575-19-2. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg. Product ID: HY-101044. | |
| PPARα agonist 6 | PPARα agonist 6 (Compound 15) is a PPARα agonist. PPARα agonist 6 can be used in the research of dyslipidemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 959699-23-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-176971. | |
| PPARγ-IN-2 | PPARγ-IN-2 (Compound 5a) is a PPARγ inhibitor. PPARγ-IN-2 inhibits TG accumulation in 3T3-L1 preadipocytes (EC50: 0.106 μM). PPARγ-IN-2 inhibits high-cholesterol diet (HFC)-induced obesity and related metabolic syndrome, and reduces lipid accumulation in adipose tissue[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2682078-97-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156010. | |
| PPM1A-IN-1 | PPM1A-IN-1 (Compound IV-4) is an inhibitor for PP2C Ser/Thr phosphatase protein phosphatase Mg2+/Mn2+-dependent 1A. PPM1A-IN-1 exhibits antibacterial activity against Mycobacterium tuberculosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2919466-30-9. Pack Sizes: 1 mg. Product ID: HY-164220. | |
| PPM-3 | PPM-3 is a potent and selective PROTAC ERK5 degrader, with an IC50 of 62.4 nM. PPM-3 did not influence tumor cell growth directly. PPM-3 influences tumor development by affecting the differentiation of macrophages[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3032388-42-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-149616. | |
| PPNDS tetrasodium | PPNDS tetrasodium is a selective and competitive meprin β inhibitor (IC50: 80 nM, Ki: 8 nM), and also inhibits ADAM10 (IC50: 1.2 μM). PPNDS tetrasodium is also a P2X1 receptor antagonist. PPNDS is an agonist for the ATP receptor of Paramecium. PPNDS tetrasodium potently inhibits polymerases from viruses. PPNDS tetrasodium can be used in the research of infection and cancers[1][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1021868-77-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-108675. | |
| PPQ-102 | PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits CFTR chloride currents (IC50 ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CFTR Inhibitor. CAS No. 931706-15-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14179. | |
| PPTN | PPTN, a chemical probe, is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and immune activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1160271-30-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-110322A. | |
| PPTN hydrochloride | PPTN hydrochloride is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN hydrochloride exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and anti-immune activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1992047-65-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110322. | |
| PPZ-A10 | PPZ-A10 is an ionizable cationic lipid. PPZ-A10 preferentially delivers mRNA to liver and spleen immune cells. Pi-LNPs containing PPZ-A10 can effectively deliver mRNA/siRNA to solid tumors[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2941268-67-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156857. | |
| PQ-10 | PQ-10 is a potent inhibitor of Phosphodiesterase 10A (PDE10A) with IC50 andED50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 927691-21-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18078. | |
| PQ401 | PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC50 of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC50, 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 196868-63-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13686. | |
| PQA-18 | PQA-18 is a unique PAK2 inhibitor (IC50: 10 nM). PQA-18 has immunosuppressing effects. PQA-18 suppresses IL2, IL4, IL6, and TNFα. PQA-18 inhibits the population of a subset of regulatory T cells and the immunoglobulin (Ig) production against T cell-dependent antigens as well as alleviates dermatitis in mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1604678-82-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-171034. | |
| PQQ-Dependent glucose dehydrogenase, microorganism | PQQ-Dependent glucose dehydrogenase, microorganismyes PQQnovel nanostructure platform for fluorescence analysis of glucose dehydrogenase-dependent glycogenase. Fluorescence signals were generated under ultraviolet excitation at a wavelength (365 nm). Uses: Scientific research. Category: Enzymes. CAS No. 81669-60-5. Pack Sizes: 1 KU; 5 KU; 10 KU. Product ID: HY-E70419. | |
| PQR514 | PQR514 is a potent PI3K inhibitor with anticancer activity. PQR514 is able to inhibit cancer cell proliferation. PQR514 showed significant antitumor activity in the OVCAR-3 xenograft model, with the required concentration being approximately one-eighth that of PQR309. PQR514 has good pharmacokinetic properties and minimal brain penetration, making it an optimized candidate compound for inhibiting systemic tumors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1927857-55-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-167876. | |
| PQR530 | PQR530 is a potent, ATP-competitive, orally bioavailable and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, with a subnanomolar Kd toward PI3Kα and mTOR (0.84 and 0.33 nM, respectively). Antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1927857-61-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107365. | |
| PQR620 | PQR620 is an orally bioavailable and selective brain penetrant inhibitor of mTORC1/2[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1927857-56-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100026. | |
| PQR626 | PQR626, a rapamycin derivative, is a potent, selective, orally active, and brain-penetrant mTOR inhibitor, with an IC50 and Ki of 5 nM and 3.6 nM, respectively. PQR626 can be can be used for the research of neurological disorders[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1927857-98-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136660. | |
| PqsR/LasR-IN-3 | PqsR/LasR-IN-3 (Compound 7a) is a potent inhibitor of PqsR and LasR systems in P. aeruginosa. PqsR/LasR-IN-3 also inhibits hERG with the IC50 of 109.01 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2581109-51-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146329. | |
| PR-619 | PR-619 is a broad-range and reversible DUB inhibitor with EC50s of 3.93, 4.9, 6.86, 7.2, and 8.61 μM for USP4, USP8, USP7, USP2, and USP5, respectively. PR-619 induces ER Stress and ER-Stress related apoptosis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2645-32-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13814. | |
| PR-924 | PR-924 is a selective tripeptide epoxyketone immunoproteasome subunit LMP-7 inhibitor with an IC50 of 22 nM. PR-924 covalently modifies proteasomal N-terminal threonine active sites. PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1416709-79-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123587. | |
| Pracinostat | Pracinostat is a potent histone deacetylase (HDAC) inhibitor, with IC50s of 40-140 nM, used for cancer research. Pracinostat also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2) hydrolase activity with an EC50 below 10 nM[1][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SB939. CAS No. 929016-96-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 1 g. Product ID: HY-13322. | |
| Pradigastat | Pradigastat (LCQ-908) is a selective and orally effective diacylglyceryl acyltransferase 1 (DGAT1) inhibitor with IC50 at 0.157 μM. Pradigastat is primarily used to study diseases associated with abnormal triglyceride metabolism. Pradigastat has anti-obesity and anti-diabetic effects. Pradigastat inhibited BCRP, OATP1B1, OATP1B3 and OAT3 activities with IC50 of 5 μM, 1.66μM, 3.34μM and 0.973μM, respectively. In addition, Pradigastat has antiviral activity and can inhibit hepatitis C virus replication in vitro[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LCQ-908. CAS No. 956136-95-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-16278. | |
| Pradofloxacin | Pradofloxacin, a third-generation fluoroquinolone antibacterial agent. Pradofloxacin can be used for the study of bacterial infections in the dog and cat, such as skin infections[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 195532-12-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W753904. | |
| Pralatrexate | Pralatrexate is an antifolate and is a potent dihydrofolate reductasean (DHFR) inhibitor with a Ki of 13.4 pM. Pralatrexate is a substrate for folylpolyglutamate synthetase with improved cellular uptake and retention. Pralatrexate has antitumor activities and has the potential for relapsed/refractory T-cell lymphoma treatment[1][2][3][4]. Pralatrexate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 146464-95-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10446. | |
| Pralidoxime chloride | Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-PAM chloride. CAS No. 51-15-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B1200. | |
| Pralnacasan | Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active interleukin-1β converting enzyme (ICE, caspase 1) inhibitor with a Ki of 1.4 nM. Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan has the potential for osteoarthritis and rheumatoid arthritis treatment[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VX-740; HMR 3480. CAS No. 192755-52-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-19676. | |
| Pralsetinib | Pralsetinib (BLU-667) is a highly potent, selective RET inhibitor. Pralsetinib (BLU-667) inhibits WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion with IC50s of 0.4, 0.3, 0.4, 0.4, and 0.4 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BLU-667. CAS No. 2097132-94-8. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112301. | |
| Praluzatamab | Praluzatamab is a monoclonal antibody targeting the activated leukocyte cell adhesion molecule (ALCAM/CD116). Praluzatamab can be used to synthesize Praluzatamab ravtansine (antibody-drug conjugates). Praluzatamab can be used for research of cancers[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CX-191; CX-2009 Antibody. CAS No. 2145109-70-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99788. | |
| Pramipexole | Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 104632-26-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-B0410. | |
| Pramipexole-d5 dihydrochloride | Pramipexole-d5 dihydrochloride is deuterium labeled Pramipexole dihydrochloride. Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1217601-58-5. Pack Sizes: 5 mg; 1 mg. Product ID: HY-17355S1. | |
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