MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| PKI(5-24) | PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 99534-03-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0222. |  |
| PKL-IN-1 | PKL-IN-1 is a potent inhibitor of pyruvate kinase (PKL) with an IC50 of 0.07 μM. PKL-IN-1 can be used in the study of non-alcoholic fatty liver disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3078059-66-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161337. | |
| PKM2-IN-1 | PKM2-IN-1 (compound 3k) is a pyruvate kinase M2 (PKM2) inhibitor with an IC50 of 2.95 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 94164-88-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103617. | |
| PKM2-IN-6 | PKM2-IN-6 (compound 7d) is a potent and orally active PKM2 inhibitor with an IC50 value of 23 nM. PKM2-IN-6 induces apoptosis and cell cycle arrest at G2 phase. PKM2-IN-6 reduces the level of PKM1 and PKM2 at the mRNA level. PKM2-IN-6 shows anticancer activity and has the potential for the research of triple-negative breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 771467-00-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157913. | |
| PKN1/2-IN-1 | PKN1/2-IN-1 is a potent cell permeabilizer and selective PKN1/2 inhibitor with IC50 values of 16 nM and 210 nM for PKN1 and PKN2, respectively, and Ki values of 8 nM and 108 nM, respectively. PKN1/2-IN-1 exhibits strong intracellular PKN2 binding capacity in NanoBRET assays (IC50 = 2.1 μM). PKN1/2-IN-1 can be used to study physiological processes such as tumor cell migration[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 942425-34-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145899. | |
| PKRA83 | PKRA83 (PKRA7) is a potent prokineticin (PK2) antagonist, which can compete for the binding of PK2 to its receptors PKR1 and PKR2. PKRA83 potently inhibits PK2 receptors, with IC50 values of 5.0 nM and 8.2 nM for PKR1 and PKR2, respectively. PKRA83 has anticancer, anti-arthritis and anti-angiogenic activities. [1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PKRA7. CAS No. 1233926-87-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147056. | |
| PKR-IN-C16 | PKR-IN-C16 (Compound C16) is a specific double-stranded RNA-dependent protein kinase (PKR) inhibitor. PKR-IN-C16 shows promising neuroprotective properties and can rescue acute brain lesions[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 608512-97-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13977A. | |
| PKR-IN-C51 | PKR-IN-C51(compound 51) is an ATP-competitive double-stranded RNA-activated protein kinase (PKR) inhibitor with an IC50 of 9 μM. PKR-IN-C51 inhibits intracellular PKR activation in a dose-dependent manner in primary mouse macrophages[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1314594-23-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118131. | |
| PKSI-527 | PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 128837-71-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123133. | |
| PK-THPP | PK-THPP is a potent and brain-penetrant TWIK-related acid-sensitive K+ ion channel (K2P9.1 or TASK-3) blocker with IC50s of 35 nM and 300 nM for TASK-3 and TASK-1, respectively. PK-THPP shows no or less activity against other K+ channels. PK-THPP is an effective breathing stimulant and can be used for the study of breathing disorders[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1332454-07-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-110184. | |
| PKUMDL-LC-101-D04 | PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 can inhibit ferroptosis and inflammation[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GPX4-Activator-1d4. CAS No. 2143896-83-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-115627. | |
| Placulumab | Placulumab (ART621) is an anti-TNF α monoclonal antibody. Placulumab has anti-inflammatory activity and has potential applications in inflammatory diseases such as arthritis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ART621; CEP-37247; PN0621. CAS No. 945781-29-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99775. | |
| Pladienolide B | Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. Pladienolide B exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. Pladienolide B induces apoptosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 445493-23-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 μg; 500 μg; 1 mg; 5 mg. Product ID: HY-16399. | |
| Plamotamab | Plamotamab (XmAb-13676) is a human bispecific antibody (bsAb) that binds CD3 and CD20. Plamotamab recruits cytotoxic T cells to kill CD20+ expressing tumor cells. Plamotamab induces a mild hematologic reaction (MR), and results in tumor regression in vivo[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: XmAb-13676. CAS No. 2138442-31-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99776. | |
| Plantainoside D | Plantainoside D, a phenylethanoid glycosides, is a IKK-β inhibitor with diverse biological activities. Plantainoside D shows inhibitory activity of angiotensin-converting enzyme (ACE) with an IC50 of 2.17 mM. Plantainoside D significantly reduces the release of glutamate from nerve terminals in the cerebral cortex of rats by inhibiting the voltage-dependent calcium channel (VDCCs) and protein kinase C (PKC) signaling cascade. Plantainoside D significantly alleviates cell apoptosis by inhibiting the generation of ROS and the activation of NF-κB. Plantainoside D significantly improves acute lung injury (ALI) induced by sepsis by regulating the Sirt3/NLRP3 signaling pathway. Plantainoside D can be used for the study of neuroprotection, antioxidant, anti-inflammation, antihypertension[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 147331-98-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N5063. | |
| Plantamajoside | Plantamajoside is an orally active phenylpropanoid glycoside. Plantamajoside can be isolated from Plantago asiatica L.(Plantaginaceae). Plantamajoside inactivates NF-κB, PI3K/akt, induces Apoptosis, and improves Autophagy. Plantamajoside regulates MAPK, integrin-linked kinase/c-Src. Plantamajoside inhibits multiple cancers, improves lung and kidney damage. Plantamajoside has neuroprotective and anti-inflammatory effects[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Uses: Scientific research. Category: Signaling pathways. CAS No. 104777-68-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0031. | |
| Plantaricin A | Plantaricin A is an antimicrobial peptide that can be derived from Lactobacillus plantarum. Plantaricin A has a synergistic effect with Ciprofloxacin. Plantaricin A shows anti-microbial activity. Plantaricin A increases the membrane potential of S. aureus and the level of intracellular ROS. Plantaricin A inhibits the function of the efflux pump by binding it and altering the structure of MepA, NorA, and LmrS. Plantaricin A significantly relieves inflammation, and promotes wound healing. Plantaricin A permeabilizes cancerous rat pituitary cells[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PlnA. CAS No. 131463-18-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5589. | |
| Platensimycin | Platensimycin is an antibiotic produced by S. platensis that inhibits gram-positive bacteria by selectively inhibiting cellular lipid biosynthesis (IC50=0.1 μM). Platensimycin targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s=48 nM and 160 nM for S.aureus and E.coli enzymes, respectively). Platensimycin is a promising agent for overcoming antibiotic resistance. Uses: Scientific research. Category: Signaling pathways. CAS No. 835876-32-9. Pack Sizes: 250 μg. Product ID: HY-127146. | |
| Platycodin D2 | Platycodin D2 is an orally active triterpenoid saponin found in Platycodon grandiflorum. Platycodin D2 induces mitophagy in cancer cells through NIX, thereby activating the P21/CyclinA2 pathway and promoting cell senescence. Platycodin D2 induces mitochondrial dysfunction, enhances autophagy, inhibits hepatocellular carcinoma cell proliferation, and exhibits anti-tumor activity against multiple cancer cell types. Platycodin D2 promotes mRNA expression of T-bet, GATA-3, Th1 cytokines IL-2 and IFN-γ, and Th2 cytokines IL-4 and IL-10, enhances splenocyte proliferation, and acts as a vaccine adjuvant with low rabbit red blood cell hemolytic activity. Platycodin D2 induces mitochondrial ROS production, incomplete autophagy, and ferroptosis to inhibit breast cancer cell proliferation. Platycodin D2 can be used for the research of cancer, inflammation and immunology[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 66663-90-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N4087. | |
| Platycodin D3 | Platycodin D3 is a triterpenoid saponin that can be found in Platycodon grandiflorum. Platycodin D3 exhibits multiple activities including anti-inflammation, regulation of airway mucus secretion, improvement of asthmatic airway inflammation and remodeling, and inhibition of hepatitis C virus (HCV) replication. The IC50 value of Platycodin D3 against HCV NS5B RNA-dependent RNA polymerase is 8 μg/mL. Platycodin D3 can be used in studies related to asthma, hepatitis C virus infection and inflammatory diseases[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 67884-03-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N3519. | |
| Platycoside E | Platycoside E is a platycodigenin-type saponin isolated from the root of Platycodon grandiflorum with haemolytic activity and adjuvant potential. Platycoside E promotes the production of the sera OVA-specific IgG2a and IgG2b antibody in the ovalbumin (OVA)-immunized mice[1]. Uses: Scientific research. Category: Natural products. CAS No. 237068-41-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N3522. | |
| Platycoside G1 | Platycoside G1, a natural product found in Platycodon grandiflorum, is a triterpenoid saponin. Platycoside G1 has potent antioxidant activities[1]. Uses: Scientific research. Category: Natural products. Alternative Names: Deapi-platycoside E. CAS No. 849758-42-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N3521. | |
| Plazinemdor | Plazinemdor (CAD-9303) is a positive allosteric modulator of N-methyl-D-aspartate (NMDA) receptors, which is used in the research of neurological diseases[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CAD-9303. CAS No. 2378285-59-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139580. | |
| Plazomicin sulfate | Plazomicin (ACHN 490) sulfate is a semi-synthetic aminoglycoside Antibiotic. Plazomicin sulfate acts as a substrate for Aminoglycoside acetyltransferase and Aminoglycoside phosphotransferase. Plazomicin sulfaten is not modified by various common aminoglycoside-modifying enzymes. Plazomicin sulfate selectively inhibits MATE2-K. Plazomicin sulfate exhibits activity against multidrug-resistant bacteria, including carbapenem-resistant Enterobacterales[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ACHN 490 sulfate. CAS No. 1380078-95-4. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg. Product ID: HY-16955A. | |
| Plecanatide | Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 467426-54-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-108741. | |
| Plecanatide acetate | Plecanatide acetate, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1075732-84-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108741A. | |
| Pleconaril | Pleconaril is a picornavirus capsid binding inhibitor that prevents attachment and/or virus uncoating. Pleconaril has potential for use in rhinoviruses and enteroviruses research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VP 63843; Win 63843. CAS No. 153168-05-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-19952. | |
| Plerixafor | Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC50 of 1-10 nM[1][2][3][4][7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMD 3100; JM3100; SID791. CAS No. 110078-46-1. Pack Sizes: 10 mM * 1 mL in Ethanol; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-10046. | |
| Plerixafor octahydrochloride | Plerixafor octahydrochloride (AMD3100 octahydrochloride) is a selective CXCR4 antagonist with an IC50 of 44 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMD3100 octahydrochloride; JM3100 octahydrochloride; SID791 octahydrochloride. CAS No. 155148-31-5. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50912. | |
| Pleuromutilin | Pleuromutilin (Drosophilin B) exhibits antibacterial activity through inhibition of protein synthesis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Drosophilin B; Mutilin 14-glycolate. CAS No. 125-65-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-N2301. | |
| PLGA (50:50) | PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications. Uses: Scientific research. Category: Signaling pathways. Alternative Names: poly(lactic-co-glycolic acid) (50:50). CAS No. 34346-01-5. Pack Sizes: 500 mg; 1 g; 2 g; 5 g. Product ID: HY-B2247. | |
| PLGA (75:25) | PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for agents, proteins and various other macromolecules such as DNA, RNA and peptides[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: poly(lactic-co-glycolic acid) (75:25). CAS No. 34346-01-5. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B2247A. | |
| Plicamycin | Plicamycin (Mithramycin A) is a selective specificity protein 1 (Sp1) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin inhibits GSTM2 promoter activity and protein expression[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Mithramycin A. CAS No. 18378-89-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0122. | |
| Plinabulin | Plinabulin (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells[1]. Plinabulin binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NPI-2358. CAS No. 714272-27-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14444. | |
| Plitidepsin | Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( KD=80 nM)[1]. Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC90 of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Aplidine; PM90001. CAS No. 137219-37-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16050. | |
| Plixorafenib | PLX8394 is a potent and selective BRaf inhibitor, with an IC50 of appr 5 nM for BRAFV600E. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PLX8394; FORE8394. CAS No. 1393466-87-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18972. | |
| PLK1/BRD4-IN-3 | PLK1/BRD4-IN-3 (Compound 21) is a selective dual inhibitor for bromodomain 4 (BRD4) and polo-like kinase 1 (PLK1). PLK1/BRD4-IN-3 inhibits BRD4-BD1, PLK1 and BRDT-BD1, with IC50s of 0.059, 0.127 and 0.245 μM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2251709-91-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160558. | |
| PLK1/BRD4-IN-5 | PLK1/BRD4-IN-5 (Compound SC10) is an orally active PLK1 and BRD4 inhibitor with IC50 values of 0.3 ?nM and 60.8? nM, respectively. PLK1/BRD4-IN-5 can induce MV4-11 cell block in S phase and apoptosis) in a dose-dependent manner. PLK1/BRD4-IN-5 can be used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3063893-60-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158031. | |
| PLN-1474 | PLN-1474 (compound 1) is an orally active and selective ανβ1 integrin inhibitor with an IC50 value of <50 nM. PLN-1474 reduces levels of pSMAD3/SMAD3 in liver, hepatic collagen gene expression and hepatic OHP concentration in liver fibrosis mouse model. PLN-1474 can be used for the research of preventing, delaying or researching a fibrotic or cirrhotic disease or disorder. Uses: Scientific research. Category: Signaling pathways. CAS No. 2408065-32-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-47888. | |
| Plogosertib | Plogosertib (CYC140) is a selective, potent, and orally active ATP-competitive PLK1 inhibitor (IC50: 3 nM). Plogosertib is an anti-cancer agent with anti-proliferative activity. Plogosertib can be used in the research of several tumors, including esophageal, gastric, leukemia, non-small cell lung cancer, ovarian, and squamous cell cancers[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CYC140. CAS No. 1137212-79-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147298. | |
| Plonmarlimab | Plonmarlimab (TJ003234) is an anti-GM-CSF monoclonal antibody. Plonmarlimab can be used for research of rheumatoid arthritis and COVID-19[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TJ003234; TJM2. CAS No. 2377482-36-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P99779. | |
| Plozalizumab | Plozalizumab (MLN-1202) is a humanized anti-CCR2 IgG1 monoclonal antibody. Plozalizumab blocks the recruitment of myeloid cells to the tumor microenvironment by inhibiting the CCL2/CCR2 axis. In addition, Plozalizumab also ameliorates synovial inflammation in rheumatoid arthritis. Plozalizumab can be used in the research of malignant melanoma and bone metastasis-related cancers. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MLN-1202. CAS No. 1610761-46-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99781. | |
| Plozasiran | Plozasiran is an siRNA targeting APOC3 for the study of mixed hyperlipidemia. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ARO-APOC3. CAS No. 2379776-40-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-164740. | |
| Plozasiran sodium | Plozasiran sodium is an siRNA targeting APOC3 for the study of mixed hyperlipidemia. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ARO-APOC3 sodium. CAS No. 2379776-41-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-164740A. | |
| PLP (139-151) | PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE). Uses: Scientific research. Category: Induced disease models products. CAS No. 131334-43-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0129. | |
| PLpro inhibitor | PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC50 of 2.6 μM[1]. PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC50 of 5.0 μM and an EC50 of 21.0 μM[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1093070-14-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17542. | |
| Plumbagin | Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities[1]. Uses: Scientific research. Category: Natural products. Alternative Names: 2-Methyljuglone. CAS No. 481-42-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-N1497. | |
| Pluripotin | Pluripotin is a dual inhibitor of ERK1 and RasGAP with KDs of 98 nM and 212 nM, respectively. Pluripotin also inhibits RSK1, RSK2, RSK3, and RSK4 with IC50s of 0.5, 2.5, 3.3, and 10.0 μM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SC1. CAS No. 839707-37-8. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10579. | |
| PluriSIn 1 | PluriSIn 1 (NSC 14613) is an inhibitor of stearoyl-coA desaturase (SCD), and is a pluripotent cell-specific inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 14613. CAS No. 91396-88-2. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-15700. | |
| PluriSIn #2 | PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 56563-17-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111630. | |
| PLX-3618 | PLX-3618 is a molecular glue, that degrades BRD4 with DC50 of 12.2 nM. PLX-3618 promotes polyubiquitination and subsequent proteasomal degradation of BRD4 by recruiting of the E3 ligase substrate receptor, DCAF11. PLX-3618 inhibits the proliferation of various cancer cells, induces apoptosis in AML cells. PLX-3618 exhibits antitumor activity against AML in mouse models[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2851986-76-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161779. | |
| PLX-4545 | PLX-4545 is an orally active, selective molecular glue degrader targeting IKZF2. Through a molecular glue mechanism, PLX-4545 binds to CRBN, recruits IKZF2 to form a ternary complex, and promotes its ubiquitination and proteasomal degradation. This further converts inhibitory regulatory T cells (Treg) into effector-like T cells, enhances CD8+ T cell responses, and modulates the Teff:Treg balance. PLX-4545 also increases the production of the inflammatory cytokine IL-2 and reduces the suppressive activity of Treg. PLX-4545 can be used in cancer immunotherapy research, and exhibits a synergistic effect when combined with immune checkpoint inhibitors such as anti-PD1[1][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2892065-45-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-159647. | |
| PLX-4720 | PLX-4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-RafV600E than wild-type B-Raf. Uses: Scientific research. Category: Signaling pathways. CAS No. 918505-84-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-51424. | |
| PLX51107 | PLX51107 is a potent and selective BET inhibitor, with Kds of 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1, and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively; PLX51107 also interacts with the bromodomains of CBP and EP300 (Kd, in the 100 nM range). Uses: Scientific research. Category: Signaling pathways. CAS No. 1627929-55-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111422. | |
| PLX5622 | PLX5622 is a highly selective brain penetrant and orally active CSF1R inhibitor (IC50=0.016 μM; Ki=5.9 nM). PLX5622 allows for extended and specific microglial cells elimination, preceding and during pathology development. PLX5622 demonstrates desirable PK properties in varies animals. PLX5622 is predominantly administered via ad libitum diets with a dose of 1200 ppm[1][2]. Uses: Scientific research. Category: Induced disease models products. CAS No. 1303420-67-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-114153. | |
| PLX647 | PLX647 is an orally active, highly specific dual FMS and KIT kinase inhibitor, with IC50s of 28 and 16 nM, respectively. PLX647 shows selectivity for FMS and KIT over a panel of 400 kinases at a concentration of 1 μM except FLT3 and KDR (IC50s=91 and 130 nM, respectively)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 873786-09-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13838. | |
| PLX7922 | PLX7922, a RAF inhibitor, can bind with BRAFV600E. PLX7922 inhibits pERK in BRAFV600E cell lines, and activates pERK in mutant NRAS cell lines[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1638772-61-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-107415. | |
| PM-1 | PM-1, a derivative of Thioflavin-T (ThT; HY-D0218), is a small but highly specific plasma membrane (PM) fluorescent dye for specific and long-time membrane imaging of living and fixed cells. PM-1 is embedded directly into the cell membrane and exhibits a very long retention time on the plasma membrane with a half-life of approximately 15 h. PM-1 can be used in combination with protein labeling probes to study ectodomain shedding and endocytosis processes of cell surface proteins[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1449483-78-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156404. | |
| PM-43I | PM-43I is a potent STAT6 inhibitor and can reduce STAT6 phosphorylation level. PM-43I can be used in allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease and cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1637532-77-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148092. | |
| PMSF | PMSF (Phenylmethylsulfonyl fluoride) is a nonspecific and irreversible serine proteases inhibitor. PMSF inhibits some thiol proteases, non-protease enzymes, and acetylcholinesterase. PMSF can be used to prepare protein extracts from tissue and cell lysates[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride. CAS No. 329-98-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0496. | |
| PMX 205 | PMX 205 is a potent complement C5a receptor (C5aR; CD88) antagonist. Uses: Scientific research. Category: Signaling pathways. CAS No. 514814-49-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110136. | |
| PMX-53 | PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC50 of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3D53. CAS No. 219639-75-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106178. | |
| PNC-27 | PNC-27, a chimeric p53-penetratin peptide binds to HDM-2 in a p53 peptide-like structure, induces selective membrane-pore formation and leads to cancer cell lysis. PNC-27 is an anticancer peptide. PNC-27 can be used in acute myeloid leukemia research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1159861-00-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P3508. | |
| PNC-28 | PNC-28 is a peptide from the mdm-2-binding domain (residues 17-26) of the p53 protein which contains a membrane crossing-penetratin sequence. PNC-28 can be used for pancreatic cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 392661-17-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3509. | |
| p-NCS-Bz-DOTA-GA | p-NCS-Bz-DOTA-GA is a bifunctional chelator. p-NCS-Bz-DOTA-GA can be used as a versatile linker in targeted molecular imaging for both PET/SPECT and MRI applications[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2194580-71-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-159181. | |
| PND-1186 | PND-1186 (VS-4718) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VS-4718; SR-2516. CAS No. 1061353-68-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13917. | |
| PND-1186 hydrochloride | PND-1186 hydrochloride (VS-4718 hydrochloride) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 hydrochloride selectively promotes tumor cell apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VS-4718 hydrochloride; SR-2516 hydrochloride. CAS No. 1356154-94-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13917A. | |
| PNGase F | PNGase F, a glycosidase, catalyzes the cleavage of an internal glycoside bond in an oligosaccharide. PNGase F removes nearly all N-linked oligosaccharides from glycoproteins. PNGase F can release N-glycans from glycoproteins in glycoanalytical workflows[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 83534-39-8. Pack Sizes: 10 KU. Product ID: HY-P2929. | |
| PNGase F-Fast | PNGase F-Fast is a glycosidase that catalyzes the cleavage of internal glycosidic bonds in oligosaccharides. PNGase F-Fast removes almost all N-linked oligosaccharides from glycoproteins. PNGase F-Fast can release N-glycans from glycoproteins in the sugar analysis workflow. The cleavage site is: the glycosidic bond between the innermost N-acetylglucosamine and asparagine. PNGase F-Fast is an improved reagent that allows for rapid deglycosylation of antibodies and antibody fusions within minutes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 83534-39-8. Pack Sizes: 50 μL. Product ID: HY-P2929A. | |
| PNGase F (Immobilized, Microspin) | PNGase F (Immobilized, Microspin) is a resin in which PNGase F (peptide N-glycosidase F) is covalently coupled to agarose beads, and it is used to remove N-glycans from antibodies, fusion proteins and other N-glycosylated proteins. The enzyme is recombinantly expressed in Escherichia coli, with its sequence derived from Flavobacterium meningsepticum[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 83534-39-8. Pack Sizes: 1 pcs. Product ID: HY-P2929B. | |
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