MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Piclamilast | Piclamilast (RP 73401) is a phosphodiesterase 4 (PDE4) inhibitor, with IC50 values of 16 nM and 2 nM in pig aorta and eosinophil soluble, respectively[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RP 73401; RPR 73401. CAS No. 144035-83-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12887. |  |
| Piclidenoson | Piclidenoson (IB-MECA) is a first-in-class, orally active and selective A3 adenosine receptor (A3AR) agonist. Piclidenoson exhibits antiproliferative effect and induces apoptosis in different cancer cell types like melanoma, leukemia. Piclidenoson can be used for the research of autoimmune inflammatory diseases and COVID-19[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IB-MECA; CF-101. CAS No. 152918-18-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13591. | |
| Picloram | Picloram is a synthetic auxin herbicide that is widely used to control dicotyledonous weed[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1918-2-1. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-B2034. | |
| Picolinic acid | Picolinic acid (PCL 016) is a topical antiviral agent, which inhibits adenovirus replication in rabbits. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PCL 016. CAS No. 98-98-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g; 50 g; 100 g; 250 g; 500 g; 1 k g. Product ID: HY-I0660. | |
| Picolinic acid-d4 | Ppicolinic-3,4,5,6-d4 acid is the deuterium labeled Ppicolinic acid[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PCL 016-d4. CAS No. 284487-61-2. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg. Product ID: HY-W259489S. | |
| Picotamide | Picotamide is a combined inhibitor of thromboxane A2 (TxA2) synthase and receptor. Picotamide has antiplatelet activity. Picotamide promotes the reduction of microalbuminuria and the inhibition of growth of carotid plaques in diabetes. Picotamide can be used for researching acute or chronic cardiovascular diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 32828-81-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-B1735. | |
| Picoxystrobin | Picoxystrobin is a strobilurin fungicide. Picoxystrobin controls plant diseases by inhibiting mitochondrial respiration. Picoxystrobin is highly toxic to zebrafish embryos, causing developmental abnormalities, oxidative stress, and immunotoxicity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 117428-22-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-136355. | |
| piCRAC-1 | piCRAC-1 is a potent, photoinducible Ca2+ release-activated Ca2+ (CRAC) channel inhibitor. piCRAC-1 alleviates thrombocytopenia and hemorrhage[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2418049-54-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147005. | |
| Picrinine | Picrinine, an akuammiline alkaloid, is isolated from the leaves of Alstonia scholaris. Picrinine exhibits anti-inflammatory activity through inhibition of the 5-lipoxygenase enzyme[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4684-32-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-N2074. | |
| Picrocrocin | Picrocrocin, an apocarotenoid found in Saffron. Picrocrocin shows anticancer effect. Picrocrocin exhibits growth inhibitory effects against SKMEL-2 human malignant melanoma cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 138-55-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N4114. | |
| Picropodophyllin | Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AXL1717; Picropodophyllotoxin; PPP. CAS No. 477-47-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15494. | |
| Picrotoxinin | Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors. Picrotoxinin inhibits α1β2γ2L GABAA receptor with an IC50 of 1.15 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 17617-45-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B1494. | |
| Pictilisib | Pictilisib (GDC-0941) is a potent inhibitor of PI3Kα/δ with an IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDC-0941. CAS No. 957054-30-7. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-50094. | |
| Piericidin A | Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity[1][2][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AR-054. CAS No. 2738-64-9. Pack Sizes: 1 mg (12.03 mM * 200 μL in Ethanol); 5 mg (12.03 mM * 1 mL in Ethanol). Product ID: HY-114936. | |
| Pifithrin-α hydrobromide | Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pifithrin hydrobromide; PFTα hydrobromide. CAS No. 63208-82-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-15484. | |
| Pifithrin-α, p-Nitro, Cyclic | Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM). Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PFN-α. CAS No. 60477-38-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123076. | |
| Pifithrin-β hydrobromide | Pifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC50 of 23 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide. CAS No. 511296-88-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16702A. | |
| Pifithrin-μ | Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PFTμ; 2-Phenylethynesulfonamide. CAS No. 64984-31-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10940. | |
| Piflufolastat | Piflufolastat (DCFPYL) can be used for the preparation of piflufolastat F 18 (DCFPyL F-18). Piflufolastat F-18 (DCFPyL F-18) is an 18F-labeled imaging agent. Piflufolastat F-18 can be used for positron emission tomography (PET) targeting prostate-specific membrane antigen (PSMA). Piflufolastat can be used for imaging of prostate cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DCFPYL. CAS No. 1423758-00-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117756. | |
| Pifusertib | Pifusertib (TAS-117) is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib induces apoptosis and autophagy[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAS-117. CAS No. 1402602-94-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-19934. | |
| Pifusertib hydrochloride | Pifusertib (TAS-117) hydrochloride is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). Pifusertib hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib hydrochloride induces apoptosis and autophagy[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAS-117 hydrochloride. CAS No. 2930090-28-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-19934A. | |
| Pigment Yellow 139 | Pigment Yellow 139 is a biological dye and indicator. Pigment Yellow 139 is an organic pigment and an additive for color filters of liquid crystal displays. When formulated in a dye-pigment hybrid system, Pigment Yellow 139 can form color filters with specific chromaticity coordinates, brightness, contrast, and average particle size[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 36888-99-0. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-D0284. | |
| PIK5-12d | PIK5-12d is a PROTAC PIKfyve degrader (DC50 = 1.48 nM). PIK5-12d induces massive cytoplasmic vacuolization and blocks autophagic flux in multiple prostate cancer cells. PIK5-12d inhibits prostate cancer cell proliferation. PIK5-12d significantly suppresses tumor proliferation in mice bearing LTL-331R human prostate cancer PDX tumors. PIK5-12d can be used for the study of prostate cancer. (Pink: PIKfyve ligand (HY-175631), Blue: VHL Ligand (HY-125845), Black: Linker, PIKfyve ligand-linker conjugate (HY-175632))[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3036457-38-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-155994. | |
| PIK-90 | PIK-90 is a DNA-PK and PI3K inhibitor, which inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 677338-12-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-12030. | |
| PIK-93 | PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM, and also inhibits PI3Kγ and PI3Kα with IC50 of 16 nM and 39 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 593960-11-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12046. | |
| Piketoprofen | Piketoprofen is a non-steroidal anti-inflammatory reagent that can be used as a cream preparation for the study of soft tissue rheumatism. Piketoprofen-amide is a prodrug of COX-2 inhibitor[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 60576-13-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-108297. | |
| PIKfyve-IN-1 | PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3phosphate 5-kinase (PIKfyve) with IC50 value of 6.9 nM. PIKfyve-IN-1 can be used for the research of PIKfyve in virology[1]. PIKfyve-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2857982-26-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151473. | |
| PIKfyve-IN-2 | PIKfyve-IN-2 is a potent PIKfyve kinase inhibitor and can be used for cancers, autoimmune disorders research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2245319-25-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-154956. | |
| PIKfyve-IN-3 | PIKfyve-IN-3 (compound L22) has a remarkable interaction with PIKfyve kinase with a Kd value of 0.47 nM. PIKfyve-IN-3 has oral activity. PIKfyve-IN-3 inhibits tumor growth in a HeLa xenograft model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3033209-92-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163133. | |
| Pilabactam sodium | Pilabactam (ANT3310) sodium is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC50 values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). Pilabactam sodium potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam sodium can be used in the research of bacterial infection[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ANT3310 sodium. CAS No. 2410688-61-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147349. | |
| Pilaralisib | Pilaralisib (XL147; SAR245408) is a potent and highly selective class I PI3Ks inhibitor with IC50s of 39 nM, 383 nM, 23 nM and 36 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ. Uses: Scientific research. Category: Signaling pathways. Alternative Names: XL-147; SAR245408. CAS No. 934526-89-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16526. | |
| Pilocarpine | Pilocarpine is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist. Uses: Scientific research. Category: Induced disease models products. CAS No. 92-13-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-B0726A. | |
| Pilocarpine Hydrochloride | Pilocarpine Hydrochloride is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist. Uses: Scientific research. Category: Induced disease models products. CAS No. 54-71-7. Pack Sizes: 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0726. | |
| Pim1/AAK1-IN-1 | Pim1/AAK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AAK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LKB1/AAK1 dual inhibitor. CAS No. 1093222-27-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-10371. | |
| PIM447 | PIM447 (LGH447) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 displays dual antimyeloma and bone-protective effects. PIM447 induces apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LGH447. CAS No. 1210608-43-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19322. | |
| PIM-447 dihydrochloride | PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 dihydrochloride induces apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LGH447 dihydrochloride. CAS No. 1820565-69-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19322B. | |
| Pimasertib | Pimasertib (AS703026) is a highly selective, ATP non-competitive allosteric orally available MEK1/2 inhibitor[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AS703026; MSC1936369B. CAS No. 1236699-92-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12042. | |
| Pimavanserin | Pimavanserin is a selective, brain-penetrant, inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ACP-103. CAS No. 706779-91-1. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14557. | |
| Pimavanserin hemitartrate | Pimavanserin (ACP-103) hemitartrate is a potent and brain-penetrant5-HT 2A receptor inverse agonist with pIC50 and pKi of 8.73 and 9.3, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ACP-103 hemitartrate. CAS No. 706782-28-7. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14557A. | |
| Pimecrolimus | Pimecrolimus (SDZ-ASM 981) is a potent, nonsteroid and orally active calcineurin inhibitor with a Ki of 117 nM. Pimecrolimus shows anti-inflammatory activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SDZ-ASM 981. CAS No. 137071-32-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13723. | |
| Pimicotinib | Pimicotinib (ABSK021) is a selective and orally active CSF1R inhibitor with an IC50 value of 19.48 nM (determined by inhibiting ADP production). Pimicotinib exhibits anti-tumor activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABSK021. CAS No. 2253123-16-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153920. | |
| Pimitespib | Pimitespib (TAS-116) is an oral bioavailable, ATP-competitive, highly specific HSP90α/HSP90β inhibitor (Kis of 34.7 nM and 21.3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94[1]. Pimitespib demonstrates less ocular toxicity[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAS-116. CAS No. 1260533-36-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15785. | |
| Pimobendan | Pimobendan (UD-CG115) is a selective inhibitor of PDE3 with IC50 of 0.32 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UD-CG115. CAS No. 74150-27-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-B0204. | |
| Pimodivir | Pimodivir (VX-787) is an orally bioavailable inhibitor of influenza A virus polymerases through interaction with the viral PB2 subunit. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VX-787. CAS No. 1629869-44-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12353A. | |
| Pimonidazole | Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor[1]. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia [2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 70132-50-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105129A. | |
| Pimonidazole hydrochloride | Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor[1]. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia [2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 70132-51-3. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-105129. | |
| Pimozide | Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R6238. CAS No. 2062-78-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-12987. | |
| PIN1 inhibitor API-1 | PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 680622-70-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116716. | |
| PIN1 ligand-1 | PIN1 ligand-1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PIN1 ligand-1 can be used for synthesis PROTAC PIN1 degrader-1 (HY-168037)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3038591-92-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-168038. | |
| Pinacidil | Pinacidil (P-1134) is a potent activator of ATP-sensitive potassium channel. Pinacidil is an antihypertensive agent hyperpolarizes vascular smooth muscle by opening K+ channels. Pinacidil enhances K+-efflux in smooth muscle. Pinacidil has vasorelaxant properties. Pinacidil is able to inhibit spontaneous tone and of reducing agonist induced contractions. Pinacidil can be studied in research area such as cardiovascular diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: P-1134. CAS No. 60560-33-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14290. | |
| Pinacyanol iodide | Pinacyanol iodide is a fluorescent cyanine dye. Pinacyanol iodide exhibits ultrafast excited state isomerization[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 605-91-4. Pack Sizes: 100 mg; 250 mg; 1 g. Product ID: HY-W216621. | |
| Pinatuzumab | Pinatuzumab is a humanized monoclonal antibody targeting cell-surface antigen CD22. Pinatuzumab can be used to synthesize antibody-drug conjugate (ADC) such as Pinatuzumab vedotin (HY-141602). Pinatuzumab can be studied in research on cancer such as non-Hodgkin lymphoma. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1639820-81-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99230. | |
| Pinatuzumab vedotin | Pinatuzumab vedotin, an antibody-drug conjugate (ADC), is a CD22 humanized monoclonal antibody Pinatuzumab (HY-P99230) conjugated to VcMMAE (HY-15575). Pinatuzumab vedotin has antitumor activities[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: anti-CD22-vc-MMAE; DCDT2980S. CAS No. 1313706-14-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-141602. | |
| Pindolol | Pindolol (LB-46) is the antagonist for 5-HT 1A (Ki=33 nM) and 5-HT 1B. Pindolol is the antagonist for β1/β2-adrenergic receptor. Pindolol exhibits anti-anxiety and antidepressant effects[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LB-46. CAS No. 13523-86-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B0982. | |
| Pinealon | Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 175175-23-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-P4052. | |
| Pinobanksin | Pinobanksin has apoptotic induction in a B-cell lymphoma cell line[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3,5,7-Trihydroxyflavanone. CAS No. 548-82-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N3062. | |
| Pinocembrin | Pinocembrin ((+)-Pinocoembrin) is a flavonoid found in propolis, acts as a competitive inhibitor of histidine decarboxylase, and is an effective anti-allergic agent, with antioxidant, antimicrobial and anti-inflammatory properties[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Pinocoembrin; Dihydrochrysin; Galangin flavanone. CAS No. 480-39-7. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg. Product ID: HY-N0575. | |
| Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside | Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside is a TRPV1 antagonist and HDAC7 inhibitor. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside blocks TRPV1-mediated calcium influx, suppresses phosphorylation of p65, IκBα, p38, JNK, and ERK1/2, inhibiting NF-κB and MAPK signaling cascades. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside reduces production and gene expression of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside exhibits potent analgesic activity, elevates thermal pain threshold and mechanical pain threshold in murine models. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside restores CD8+ T cell infiltration into bladder cancer tumors and improves bladder cancer immunotherapy efficacy. Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside can be used for the researches of painand bladder cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 205370-59-8. Pack Sizes: 10 mM * 1 mL in Ethanol; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N5084. | |
| Pinolenic acid | Pinolenic acid (PNLA) is a polyunsaturated fatty acid that can be isolated from Pinus orientalis and Pinus pinaster seed oil. Pinolenic acid has anti-inflammatory and lipid-lowering activities[1]. Uses: Scientific research. Category: Natural products. Alternative Names: PNLA. CAS No. 16833-54-8. Pack Sizes: 5 mg (35.92 mM * 500μL in Ethanol); 10 mg (35.92 mM * 1mL in Ethanol). Product ID: HY-119546. | |
| Pinolenic acid methyl ester | Pinolenic acid methyl ester is the methylated product of pinolenic acid, which can be used for the analysis of fatty acid content[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 38406-57-4. Pack Sizes: 1 mg (34.19 mM * 100 μL in Ethanol); 5 mg (34.19 mM * 500 μL in Ethanol); 10 mg (34.19 mM * 1 mL in Ethanol). Product ID: HY-W744867. | |
| Pinometostat | Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor with a Ki of 80 pM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EPZ-5676. CAS No. 1380288-87-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15593. | |
| Pinoresinol | Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Pinoresinol. CAS No. 487-36-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-N6253. | |
| (-)-Pinoresinol | (-)-Pinoresinol is a plant-derived tetrahydrofuran lignan that inhibits α-glucosidase and acts as a hypoglycemic agent. (-)-Pinoresinol has some anti-inflammatory effects and acts as a chemopreventive agent, inducing increased apoptosis and cell cycle G2/M arrest[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 81446-29-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-126067. | |
| Pinoresinol Diglucoside | Pinoresinol Diglucoside is an orally active lignan with multifunctional bioactivity. Pinoresinol Diglucoside interacts with targets including ALB, HIF1A, GSK3B, BCL2, MARK3, IL6, NF-κB p65, Nrf2, HO-1, and TLR4, and modulates pathways including PI3K-Akt, estrogen, MAPK, Rap1, AKT/mTOR/NF-κB, and TGF-β1/Smads. Pinoresinol Diglucoside regulates osteogenesis, bone resorption, oxidative stress, inflammation, apoptosis, ferroptosis, ferritinophagy, cardiac fibrosis, and vasorelaxation. Pinoresinol Diglucoside can be used for the research of osteoporosis, ischemia/reperfusion-induced brain injury, Alzheimers disease, myocardial ischemia-reperfusion injury, chondrodysplasia, diabetic cardiomyopathy, cardiac hypertrophy, hypertension, cisplatin-induced hearing loss, atherosclerotic cardiovascular diseases, and disuse osteoporosis[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. Uses: Scientific research. Category: Signaling pathways. CAS No. 63902-38-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0657. | |
| Pinostrobin | Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. CAS No. 480-37-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N2127. | |
| Pinoxaden | Pinoxaden, a member of the phenylpyrazolines class, is a selective post-emergence herbicide extensively utilized to control various annual grass weeds. Uses: Scientific research. Category: Signaling pathways. CAS No. 243973-20-8. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W425676. | |
| Pioglitazone | Pioglitazone (U 72107) is an orally active and selective PPARγ (peroxisome proliferator-activated receptor) agonist with high affinity binding to the PPARγ ligand-binding domain with EC50 of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone can be used in diabetes research[2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: U 72107. CAS No. 111025-46-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13956. | |
| Pioglitazone hydrochloride | Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: U 72107A; AD 4833. CAS No. 112529-15-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-14601. | |
| Pioglitazone hydrochloride (Standard) | Pioglitazone (hydrochloride) (Standard) is the analytical standard of Pioglitazone (hydrochloride). This product is intended for research and analytical applications. Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: U 72107A (Standard); AD 4833 (Standard). CAS No. 112529-15-4. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14601R. | |
| PIP-199 | PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 622795-76-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-124325. | |
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