MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| PHA 408 | PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 503555-55-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-14180. |  |
| PHA-543613 | PHA-543613 is a potent, orally active, brain-penetrant and selective α7 nAChR agonist with a Ki of 8.8 nM. PHA-543613 displays selectivity for α7-nAChR over α3β4, α1β1γδ, α4β2 and 5-HT3 receptors[1]. PHA-543613 can be used for the cognitive deficits of Alzheimer's disease and schizophrenia research[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 478149-53-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105670. | |
| PHA-665752 | PHA-665752 is a selective, ATP-competitive, and active-site inhibitor of the catalytic activity of c-Met kinase (Ki=4 nM; IC50=9 nM). PHA-665752 exhibits >50-fold selectivity for c-Met compared with a panel of diverse tyrosine and serine-threonine kinases. PHA-665752 induces apoptosis and cell cycle arrest, and exhibits cytoreductive antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 477575-56-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11107. | |
| PHA-767491 | PHA-767491 is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CAY10572. CAS No. 845714-00-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-13461. | |
| PHA-767491 hydrochloride | PHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CAY-10572 hydrochloride. CAS No. 942425-68-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13461A. | |
| PHA-793887 | PHA-793887 is a potent, ATP-competitive CDK inhibitor, can inhibit Cdk2, Cdk1, Cdk4, and Cdk9 with IC50s of 8 nM, 60 nM, 62 nM and 138 nM, respectively, and also inhibits glycogen synthase kinase 3β with an IC50 of 79 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 718630-59-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11001. | |
| Phaclofen | Phaclofen is a selective GABAB receptor antagonist. Phaclofen is a peripheral and central baclofen antagonist. Phaclofen maybe a potential compound in determining the physiological significance of central and peripheral bicuculline-insensitive receptors with which GABA and (-)-baclofen interact[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 114012-12-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-100798. | |
| Phalloidin-TRITC | Phalloidin-TRITC is a fluorescein derivative of Phalloidin, which can specifically label myof lin and display red fluorescence when labeled and can be observed using Tesred channels[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 915013-10-4. Pack Sizes: 10 μg; 25 μg. Product ID: HY-P2270. | |
| Phaseic acid | Phaseic acid is a Abscisic acid terpenoid catabolite that can able to activate a subset of Abscisic acid repectors. Phaseic acid is a plant hormone associated with photosynthesis arrest and abscission. Phaseic acid is the antagonist for NMDA-type glutamate receptor (NMDAR) that inhibits NMDAR currents with an IC50 of 34.37 μM. Phaseic acid reduces intracellular calcium influx, and exhibits neuroprotective effect[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 24394-14-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-111973. | |
| Phaseoloidin | Phaseoloidin is an orally active multi-target inhibitor. Phaseoloidin inhibits the activation of the NLRP3 inflammasome and blocks the caspase-11-GSDMD pyroptosis axis. Phaseoloidin reduces the expression of collagen-degrading enzymes to maintain the integrity of cartilage matrix. Phaseoloidin activates the AMPK/mTOR pathway to enhance autophagy function and reverse apoptosis resistance. Phaseoloidin inhibits the growth and development of Manduca sexta and Spodoptera littoralis larvae, thereby helping Nicotiana attenuata defend against lepidopteran herbivorous insects. Phaseoloidin can be used in research related to acute gouty arthritis and pulmonary fibrosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 118555-82-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N7400. | |
| Phellopterin | Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2543-94-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N2110. | |
| Phe-Met-Arg-Phe amide trifluoroacetate | Phe-Met-Arg-Phe amide trifluoroacetate is an activator of K+ current, with ED50 of 23 nM in the peptidergic caudodorsal neurons. Uses: Scientific research. Category: Signaling pathways. CAS No. 159237-99-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P0249A. | |
| Phenacetin | Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Acetophenetidin. CAS No. 62-44-2. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0476. | |
| Phenamacril (Standard) | Phenamacril (Standard) is the analytical standard of Phenamacril. This product is intended for research and analytical applications. Phenamacril (JS399-19) inhibits activity of myosin I non-competitively with an IC50 of 360 nM through suppression of the ATPase activity, exhibits therefore an antifungal efficacy towards Fusarium species[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JS399-19 (Standard). CAS No. 39491-78-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-122200R. | |
| Phenamil methanesulfonate | Phenamil methanesulfonate, an analog of Amiloride (HY-B0285), is a more potent and less reversible epithelial sodium channel (ENaC) blocker with an IC50 of 400 nM[2]. Phenamil methanesulfonate is also a competive inhibitor of TRPP3 and inhibits TRPP3-mediated Ca2+ transport with an IC50 of 140 nM in a Ca2+ uptake assay[1]. Phenamil methanesulfonate is an intriguing small molecule to promote bone repair by strongly activating BMP signaling pathway[4]. Phenamil methanesulfonate is used for the research of cystic fibrosis lung disease[5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1161-94-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-108464A. | |
| Phenanthriplatin | Phenanthriplatin is a monovalent platinum(II)-based complex with a large cytotoxicity against cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1416900-51-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139813. | |
| Phenazine-1-carboxylic acid | Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2538-68-3. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-33037. | |
| Phenazine ethosulfate | Phenazine ethosulfate is a cationic dye (Ex=390 nm, Em=530 nm) and an electron acceptor that can be used in dye-linked enzyme assays. Phenazine ethosulfate is an intermediate for detecting nitric oxide reducatase (Nors) activity with the presence of ascorbic acid[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 10510-77-7. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-D1509. | |
| Phenazine methylsulfate | Phenazine methylsulfate is a free radical generator that can act as an electron transfer reactant in cell viability assays. It also has insecticidal properties. Furthermore, Phenazine methylsulfate induces oxidative DNA damage and cell apoptosis, showing antitumor activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5-Methylphenazinium methylsulfate. CAS No. 299-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-W004520. | |
| Phenazopyridine | Phenazopyridine is a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine is a TRPM8 antagonist. Phenazopyridine has a local anesthetic/analgesic effect. Phenazopyridine is used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine can promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 94-78-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B0985A. | |
| Phenazopyridine hydrochloride | Phenazopyridine hydrochlorideis a competitive SARM1 inhibitor, with IC50 145 μM. Phenazopyridine hydrochlorideis a TRPM8 antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 136-40-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g. Product ID: HY-B0985. | |
| Phen-DC3 Trifluoromethanesulfonate | Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand which can inhibit FANCJ and DinG helicases with IC50s of 65±6 and 50±10 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Phen-DC3 Triflate. CAS No. 929895-45-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15594A. | |
| Phenelzine sulfate | Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active-monoamine oxidase (MAO-A and MAO-B)-inhibitor. Phenelzine sulfate inhibits-GABA transaminase-and-primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits-LSD1-(Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinsons disease, Alzheimers disease, inflammatory pain, obesity and prostate cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 156-51-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B1018A. | |
| Phenethyl ferulate | Phenethyl ferulate is a major constituent ofQianghuo, shows inhibitory activity against cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) with IC50 values of 4.35 μM and 5.75 μM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 71835-85-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W009248. | |
| Phenformin | Phenformin (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent. Phenformin inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin inhibits cancer stem cells (CSCs) and possesses potent antitumor potential[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Phenethylbiguanide. CAS No. 114-86-3. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16397. | |
| Phenformin hydrochloride | Phenformin (Phenethylbiguanide) hydrochloride is an orally active biguanide hypoglycemic agent. Phenformin hydrochloride inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin hydrochloride inhibits cancer stem cells (CSCs) and possesses potent antitumor potential[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Phenethylbiguanide hydrochloride. CAS No. 834-28-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-16397A. | |
| Phen Green SK diacetate (5/6-mixture) | Phen green SK (PGSK) diacetate (PGSK diacetate (5/6-mixture)) is a metal ion-sensitive fluorescent probe that can penetrate cell membranes. Phen green SK (PGSK) diacetate can react with a variety of metal ions, including Fe2+, Cd2+, Co2+, Ni2+, Zn2+, etc. Phen green SK (PGSK) diacetate chelates Fe2+, resulting in fluorescence quenching, which can be restored when a membrane-permeable chelator is added, thereby reflecting the changes in the intracellular chelatable iron pool. The excitation/emission maxima of Phen green SK diacetate are 507/532 nm, respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PGSK diacetate (5/6-mixture). CAS No. 234075-45-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-126823. | |
| Phenol Red | Phenol red (Phenolsulfonephthalein) is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction[1] [2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Phenolsulfonephthalein. CAS No. 143-74-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 25 g. Product ID: HY-D0169. | |
| Phenoxodiol | Phenoxodiol (Idronoxil), a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Idronoxil; Dehydroequol; Haginin E. CAS No. 81267-65-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13721. | |
| Phenoxybenzamine hydrochloride | Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine hydrochloride also shows antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 63-92-3. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-B0431A. | |
| Phenserine | Phenserine ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine (HY-N6608) and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine improves cognitive performance and attenuates the progression of Alzheimer's disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Eseroline phenylcarbamate; (-)-Phenserine. CAS No. 101246-66-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-103374. | |
| Phensuximide | Phensuximide is an orally active succinimide antiepileptic and anticonvulsant agent. Phensuximide inhibits cyclic AMP and cyclic GMP accumulation in depolarized brain tissue. Phensuximide can be used for the study of seizure and petit mal[1][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 86-34-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1730. | |
| Phentolamine | Phentolamine is an orally active, selective α1 and α2 Adrenergic receptor antagonist. Phentolamine antagonizes the vasodilatory effect of Cromakalim (HY-110011) on isolated circumflex coronary artery segments in dogs. Phentolamine reduces systemic vascular resistance and increases cardiac output. Phentolamine improves erectile dysfunction. Phentolamine can be used for the research of erectile dysfunction[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 50-60-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-12717. | |
| Phentolamine hydrochloride | Phentolamine hydrochloride is an orally active, selective α1 and α2 Adrenergic receptor antagonist. Phentolamine hydrochloride antagonizes the vasodilatory effect of Cromakalim (HY-110011) on isolated circumflex coronary artery segments in dogs. Phentolamine hydrochloride reduces systemic vascular resistance and increases cardiac output. Phentolamine hydrochloride improves erectile dysfunction. Phentolamine hydrochloride can be used for the research of erectile dysfunction[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 73-05-2. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-12717A. | |
| Phentolamine mesylate | Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Phentolamine methanesulfonate. CAS No. 65-28-1. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg. Product ID: HY-B0362A. | |
| Phenylacetylglutamine | Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 203800; Phenylacetyl-L-glutamine. CAS No. 28047-15-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W050026. | |
| Phenylacetylglutamine-d5 | Phenylacetylglutamine-d5 (NSC 203800-d5) is the deuterium labeled Phenylacetylglutamine (HY-W050026). Phenylacetylglutamine is a colonic microbial metabolite from amino acid fermentation[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 203800-d5; Phenylacetyl-L-glutamine-d5. CAS No. 1331909-01-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-W050026S. | |
| Phenylalanine-4-azobenzene HCl | Phenylalanine-4-azobenzene HCl is an alanine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2137036-84-9. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W141859. | |
| Phenylarsine oxide | Phenylarsine oxide (PAO), an inhibitor of endocytosis, inhibits PTPε with an IC50 of 18 μM. Phenylarsine oxide (PAO) inhibits oxygen consumption and decreases cellular ATP content overlap with those used to inhibit protein internalization[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Oxophenylarsine; PhAsO; Arsenosobenzene. CAS No. 637-03-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-131901. | |
| Phenyl β-D-glucopyranoside | Phenyl β-D-glucopyranoside is a component isolated from Phellodendron amurense, which has anti-inflammatory and anti-tumor activities. Phenyl β-D-glucopyranoside inhibits nitric oxide (NO) production, and the expression of iNOS and COX-2. Phenyl β-D-glucopyranoside also inhibits the nuclear translocation of NF-κB. Phenyl β-D-glucopyranoside inhibits the expression of pro-inflammatory cytokines and related genes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1464-44-4. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W011849. | |
| Phenylcapsaicin | Phenylcapsaicin is an analogue of Capsaicin (HY-10448). Phenylcapsaicin is a TRPV1 receptor activator. Phenylcapsaicin enhances fat oxidation during aerobic exercise[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 848127-67-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-158110. | |
| Phenylephrine | (R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist primarily used as a decongestant. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-(-)-Phenylephrine; L-Phenylephrine. CAS No. 59-42-7. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg. Product ID: HY-B0769. | |
| Phenylephrine hydrochloride | (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-(-)-Phenylephrine hydrochloride; L-Phenylephrine hydrochloride. CAS No. 61-76-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-B0471. | |
| Phenylephrine (Standard) | Phenylephrine (Standard) is the analytical standard of Phenylephrine. This product is intended for research and analytical applications. (R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist primarily used as a decongestant. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-(-)-Phenylephrine (Standard); L-Phenylephrine (Standard). CAS No. 59-42-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0769R. | |
| Phenylglyoxylic acid-d5 | Phenylglyoxylic acid-d5 (Benzoylformic acid-d5) is a deuterium labeled Phenylglyoxylic acid (HY-W010255). Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human. Phenylglyoxylic acid can be used as drug intermediate for synthesis of antineoplastic compounds[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Benzoylformic acid-d5. CAS No. 1217089-53-6. Pack Sizes: 5 mg. Product ID: HY-W010255S. | |
| Phenylpyruvic acid | Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. Phenylpyruvic acid can improve the antifungal activity of eight lactic acid bacterial strains through the addition into a dedined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants Aspergillus niger and Penicillium roqueforti. Phenylpyruvic acid affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates. Phenylpyruvic acid can reduce glucose-6-phosphate dehydrogenase activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 156-06-9. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W012530. | |
| Phenylthiourea | Phenylthiourea (Phenylthiocarbamide) is an inhibitor for phenoloxidase. Phenylthiourea inhibits enzymatic oxidation of DOPA by phenoloxidase (Ki = 0.21 μM). Phenylthiourea is an effective inhibitor for tyrosinase. Phenylthiourea can lead to graying of hair in black rats due to the interference with melanin formation[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Phenylthiocarbamide. CAS No. 103-85-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-Y0351. | |
| Phenytoin | Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: 5,5-Diphenylhydantoin. CAS No. 57-41-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0448. | |
| Phenytoin-d10 | Phenytoin-d10 is the deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5,5-Diphenylhydantoin-d10. CAS No. 65854-97-9. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg. Product ID: HY-B0448S. | |
| Pheophorbide A | Pheophorbide A is an intermediate product in the chlorophyll degradation pathway. Pheophorbide A can be used as a photosensitizer. Pheophorbide A is a lymphatic vascular activator. Pheophorbide A has antitumor activity. Pheophorbide A can be used for human lymphatic vascular insufficiencies research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 15664-29-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-125665. | |
| Pheophytin a | Pheophytin a is a multi-target inhibitor, anticancer agent, antioxidant and antiviral agent. Pheophytin a directly binds to and inhibits HCV-NS3/4A protease (IC50=0.89 μM) to block viral replication. Pheophytin a also scavenges free radicals, reduces ferric ions, and exhibits cytotoxic activity against breast cancer cells. Pheophytin a effectively inhibits LPS-induced production of nitric oxide, prostaglandin E2, NOS2 and COX-2, as well as various pro-inflammatory cytokines, by downregulating the transcription levels of inflammatory mediators and blocking the ERK1/2 and STAT-1 pathways. In a low nerve growth factor environment, Pheophytin a also enhances ERK1/2 phosphorylation and synergistically promotes neurite outgrowth through MAPK pathway. Pheophytin a can be used to investigate the pathogenic mechanisms of diseases including chronic hepatitis C, sepsis, breast cancer and Alzheimer's disease[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 603-17-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N12586. | |
| PHF6 | PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 329897-62-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P4808. | |
| PHGDH-IN-5 | PHGDH-IN-5 (Compound B12) is a covalen inhibitor of PHGDH with an IC50 value of 0.29 μM. PHGDH-IN-5 can inhibit cell proliferation in cancer cell lines overexpressing PHGDH. PHGDH-IN-5 can reduce the production of serine derived from glucose in MDA-MB-468 cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 17402-86-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161456. | |
| Philanthotoxin 74 dihydrochloride | Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PhTx 74 dihydrochloride. CAS No. 1227301-51-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-104020A. | |
| Phillyrin | Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities[1]. Phillyrin has anti-influenza A virus activities[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 487-41-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 20 mg. Product ID: HY-N0482. | |
| PhIP | PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat[1][2]. DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity[2]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. CAS No. 105650-23-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118716. | |
| Phleomycin | Phleomycin is a copper-dependent DNA damaging agent and antibiotic with antitumor activity. Phleomycin binds to DNA and produces ROS in the presence of reducing agents (such as dithiothreitol and glutathione), inducing single-strand and double-strand breaks in DNA. Phleomycin can induce cell apoptosis or mutation and is widely used in cancer inhibition, microbial genetic transformation (as a screening marker to improve fungal transformation efficiency) and DNA repair mechanism research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 11006-33-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126490. | |
| Phleomycin D1 | Phleomycin D1 (PLM D1), a glycopeptide antibiotic, is a member of the Bleomycin/Phleomycin family. Phleomycin D1 causes cell death by binding and cleaving DNA. Phleomycin D1 induces cell cycle arrest at S phase[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PLM D1. CAS No. 11031-11-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-111428. | |
| Phloretin | Phloretin (NSC 407292; RJC 02792) is a flavonoid extracted from Malus pumila Mill., has anti-inflammatory activities. Phloridzin is a specific, competitive and orally active inhibitor of sodium/glucose cotransporters in the intestine (SGLT1) and kidney (SGLT2). Phloretin inhibits Yeast-made GLUT1 as well as Human erythrocyte GLUT1 with IC50values of 49 μM and 61 μM, respectively[1].Phloretin has the potential for the treatment of rheumatoid arthritis (RA) and allergic airway inflammation[4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 407292; RJC 02792. CAS No. 60-82-2. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-N0142. | |
| Phlorizin | Phlorizin (Floridzin) is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC50 of 0.04 μM and a Ki of 39 nM against hSGLT2, and an IC50 of 0.17 μM and a Ki of 0.31 μM against hSGLT1. Phlorizin promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin also exhibits antibacterial, anti-inflammatory and neuroprotective activities[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Floridzin. CAS No. 60-81-1. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-N0143. | |
| pH-Low Insertion Peptide | pH-Low Insertion Peptide (pHLIP) is a short, pH-responsive peptide capable of inserting across a cell membrane to form a transmembrane helix at acidic pH. pH-Low Insertion Peptide targets the acidic tumor microenvironment for tumors at early and metastatic stages with high specificity, used as a specific ligand. pH-Low Insertion Peptide successfully modify polylysine polymers to have the pH-responsive capability. pH-Low Insertion Peptide-based targeting of cancer presents an opportunity to monitor metabolic changes, and to selectively deliver imaging and therapeutic agents to tumors[1][2][3]. Uses: Scientific research. Category: Peptides. Alternative Names: pHLIP. CAS No. 2293160-09-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P4116. | |
| PHM-27 (human) | PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 87403-73-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1072. | |
| Phoenixin-14 | Phoenixin-14 (PNX-14) is one of the endogenous active isoform, and generates anxiolytic effect via the activation of the AHA GnRH system in mice. Phoenixin-14 inhibits ischemia/reperfusion-induced cytotoxicity in microglia[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PNX-14. CAS No. 1415039-79-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5762. | |
| Phoenixin-20 | Phoenixin-20 (PNX-20) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. Phoenixin-20 has anxiolytic effect[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PNX-20. CAS No. 1415039-77-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5763. | |
| PHOME | PHOME is a fluorogenic substrate for sEH. sEH can hydrolyze the epoxy ring in the PHOME substrate. PHOME can be used for fluorescent epoxide hydrolase assay[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1028430-42-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-113862. | |
| Phorbol | Phorbol is the flagship member of the tigliane diterpene family. Phorbol can be isolated from natural sources and through semisynthesis. Phorbol can form esters that have a wide array of biological properties, which includes the induction of angiogenesis in vitro and promoting tumor in vivo[1][2][3]. Uses: Scientific research. Category: Natural products. Alternative Names: 4β-Phorbol. CAS No. 17673-25-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2147. | |
| Phorbol 12,13-dibutyrate | Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator and a potent skin tumor promoter[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Phorbol dibutyrate; PDBu. CAS No. 37558-16-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18985. | |
| Phorbol-12,13-didecanoate | Phorbol-12,13-didecanoate is an anti-viral TPA compound and a tumor promoter. It can cause changes in actin-containing structures[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 24928-17-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-160070. | |
| Phorbol 12-myristate 13-acetate | Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator[1][2]. Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells (Validated by MedChemExpress (MCE))[3][7]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: PMA; TPA; Phorbol myristate acetate. CAS No. 16561-29-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18739. | |
| Phorbol 12-myristate 13-acetate (Standard) | Phorbol 12-myristate 13-acetate (PMA; TPA; Phorbol myristate acetate) (Standard) is the analytical standard of Phorbol 12-myristate 13-acetate. This product is intended for research and analytical applications. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PMA (Standard); TPA (Standard); Phorbol myristate acetate (Standard). CAS No. 16561-29-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18739R. | |
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