MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| PDS-MMAE | PDS-MMAE (Compound 5) is a modified MMAE (HY-15162). PDS-MMAE can be used for preparation of neurotensin receptor binding conjugates[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1613113-44-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153958. |  |
| PDZ1i | PDZ1i (113B7) is a inhibitor of MDA-9/Syntenin, with selective binding to the PDZ1 domain. PDZ1i inhibits radiation-induced invasion of glioblastoma (GBM) cells, radiosensitizes GBM cells, and impairs GBM-related signaling pathways (including Src/EphA2, EGFRvIII/FAK, and NF-κB). PDZ1i reduces radiation-induced secretion of invasion-related proteases (MMP-2, MMP-9, ADAM9). PDZ1i shows anti-tumor effects in nude mice bearing intracranial U1242-luc xenografts or GBM xenografts. PDZ1i can be used for the study of glioblastoma (GBM), breast cancer and prostate cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 113B7. CAS No. 2083618-79-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-124813. | |
| PE 22-28 | PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1801959-12-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3581. | |
| PE859 | PE859 is a potent inhibitor of both tau and Aβ aggregation with IC50 values of 0.66 and 1.2 μM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1402727-29-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12662. | |
| Pectate Lyase | Pectate Lyase is an enzyme that exists in microorganisms, plants and animals. Pectate Lyase degrades pectic acid via the β-elimination mechanism. Pectate Lyase induces plant immune responses and participates in virulence. Pectate Lyase is applied in fields such as plant fiber degumming and fruit and vegetable processing[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9015-75-2. Pack Sizes: 7 KU. Product ID: HY-E70119. | |
| Pectinase, aspergillus niger | Pectinase (EC 3.2.1.15) is a mixed enzymes that hydrolyze pectic substances, it mostly presents in microorganisms and higher plants. Pectinase is involved in the metabolism of the cell wall as well as in the growth of the cell, senescence, ripening of fruits, pathogenesis and abscission process[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EC 3.2.1.15. CAS No. 9032-75-1. Pack Sizes: 5 g; 10 g; 50 g. Product ID: HY-126386. | |
| Pectinase, rhizobia | Pectinase, rhizobia is a mixed enzymes that hydrolyze pectic substances, it mostly presents in microorganisms and higher plants. Pectinase is involved in the metabolism of the cell wall as well as in the growth of the cell, senescence, ripening of fruits, pathogenesis and abscission process[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Macerozyme R-10. CAS No. 9032-75-1. Pack Sizes: 500 U; 1 KU. Product ID: HY-126386B. | |
| Pectolinarigenin | Pectolinarigenin is an orally active dual inhibitor of COX-2/5-LOX with anti-inflammatory, antioxidant, antitumor and neuroprotective activities. Pectolinarigenin exerts neuroprotective and anti-inflammatory effects on astrocyte inflammation via the NFκB and MAPK pathways. Pectolinarigenin inhibits LPS-induced phosphorylation of ERK1/2, N-FκB and p38MAPK, directly inhibits the enzymatic activity or binding of COX-2, 5-LOX and HIF-1α, and reduces the level of XIAP. Pectolinarigenin modifies Keap1 to promote nuclear accumulation of Nrf2, induces ARE-mediated antioxidant enzyme expression, and possesses direct free radical scavenging activity. Pectolinarigenin reduces the release of NO, proinflammatory mediators and leukotrienes, and increases the level of IL-10. Pectolinarigenin induces G2/M cell cycle arrest, apoptosis (Apoptosis) and autophagy (Autophagy) via the PI3K/AKT/mTOR signaling pathway. Pectolinarigenin reduces renal crystal deposition and inhibits melanin synthesis. Pectolinarigenin inhibits inflammation and alleviates allergy in mouse models of inflammation. Pectolinarigenin alleviates renal injury, inflammation and oxidative stress in mice by inhibiting HIF-1α activity. Pectolinarigenin can be used for the research of neurodegenerative diseases, inflammatory/allergic diseases, calcium oxalate nephrocalcinosis, gastric cancer, melasma, post-inflammatory diseases and chloasma[1][2][3][4] | |
| Pectolyase Y-23, A. japonicus | Pectolyase Y-23, A. japonicus is an enzyme derived from Aspergillus japonicas. Pectolyase Y-23, A. japonicus can be used in combination with cellulase to isolate bioactive protoplasts[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9033-35-6. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-E70396. | |
| Pedaliin | Pedaliin is a bioactive component obtained from the ethanol extract of Sesame (Sesamum indicum L.) leaves (SLs). Pedaliin shows in vitro antioxidant and anti-colon cancer efficacy with radical scavenging activity and ferric reducing antioxidant power (FRAP)[1][2]. Uses: Scientific research. Category: Natural products. CAS No. 22860-72-6. Pack Sizes: 1 mg. Product ID: HY-N9588. | |
| Pedalitin | Pedalitin is a inhibitor of tyrosinase (IC50=0.28 mM) and α-glucosidase (IC50=0.29 mM) [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 22384-63-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N3101. | |
| Pedunculoside | Pedunculoside exerts lipid-lowering effects partly through the regulation of?lipogenesis?and?fatty acid β-oxidation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 42719-32-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0458. | |
| Peficitinib | Peficitinib (ASP015K) is an orally active JAK inhibitor, with IC50s of 3.9, 5.0, 0.7 and 4.8 nM for JAK1, JAK2, JAK3 and Tyk2, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASP015K; JNJ-54781532. CAS No. 944118-01-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19568. | |
| PEG10000 | PEG10000 (Polyethylene glycol 10000) can be used as a solubilizer. PEG10000 is a kind of biological materials or organic compounds that are widely used in life science research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyethylene glycol 10000. CAS No. 25322-68-3. Pack Sizes: 25 g; 50 g; 100 g. Product ID: HY-Y0873P. | |
| PEG1500 | PEG1500 can be used as an excipient, such as ointment base, lubricant. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyethylene glycol 1500. CAS No. 25322-68-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 g; 500 g. Product ID: HY-Y0873E. | |
| PEG200 | PEG200 (Polyethylene glycol 200), a neutral polymer of molecular weight 200, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyethylene glycol 200. CAS No. 25322-68-3. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 50 g; 100 g; 500 g. Product ID: HY-Y0873K. | |
| PEG2000 | PEG2000 (Polyethylene glycol 2000) is a solvent for a large number of substances. PEG2000 can be used as a carrier material and modifying agent. PEG2000 is widely used in a variety of pharmaceutical formulations[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyethylene glycol 2000. CAS No. 25322-68-3. Pack Sizes: 10 mM * 1 mL in DMSO; 250 g; 500 g; 1 k g. Product ID: HY-Y0873B. | |
| PEG20000 | PEG20000 (Polyethylene glycol 20000) can be used as a solubilizer. PEG20000 is a kind of biological materials or organic compounds that are widely used in life science research, can be degraded by bacteria[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyethylene glycol 20000. CAS No. 25322-68-3. Pack Sizes: 100 g; 250 g; 500 g; 1 k g. Product ID: HY-Y0873Q. | |
| PEG(2000)-C-DMG | PEG(2000)-C-DMG is a PEGylated derivative of 1,2-Dimyristoyl-sn-glycerol (HY-128468). PEG(2000)-C-DMG can be used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of siRNA[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1443687-74-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-168399. | |
| PEG2000-C-DMG | PEG2000-C-DMG, a pegylated lipid, can be used for the preparation of Onpattro. Onpattro, a hepatically directed investigational RNAi therapeutic agent, harnesses this process to reduce the production of mutant and wild-type transthyretin by targeting the 3 untranslated region of transthyretin mRNA[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1443687-74-8. Pack Sizes: 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-145411. | |
| PEG300 | PEG300 (Polyethylene glycol 300), a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyethylene glycol 300. CAS No. 25322-68-3. Pack Sizes: 50 mL; 100 mL; 200 mL; 500 mL. Product ID: HY-Y0873. | |
| PEG3000 | PEG3000 (Polyethylene glycol 3000) is a solvent for a large number of substances. PEG3000 can be used as a carrier material and modifying agent. PEG3000 is widely used in a variety of pharmaceutical formulations[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyethylene glycol 3000. CAS No. 25322-68-3. Pack Sizes: 100 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-Y0873N. | |
| PEG3350 | PEG3350 (Polyethylene glycol 3350) a neutral polymer of molecular weight 3350. PEG3350 used as an excellent solvent for a large number of substances. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyethylene glycol 3350. CAS No. 25322-68-3. Pack Sizes: 25 g; 50 g; 100 g; 500 g. Product ID: HY-Y0873C. | |
| PEG35000 | PEG35000 is a polyethylene glycol with a molecular weight of 35,000 that can be used as a carrier material and modifier in drug delivery systems[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyethylene glycol 35000. CAS No. 25322-68-3. Pack Sizes: 100 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-Y0873O. | |
| PEG400 | PEG400 is a strongly hydrophilic polyethylene glycol used as an excellent solvent for a large number of substances. PEG400 is widely used in a variety of pharmaceutical formulations. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyethylene glycol 400. CAS No. 25322-68-3. Pack Sizes: 50 mL; 100 mL. Product ID: HY-Y0873A. | |
| PEG4000 | PEG4000 can be used as an excipient, such as Ointment base, lubricant, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyethylene glycol 4000. CAS No. 25322-68-3. Pack Sizes: 5 g; 10 g; 50 g; 100 g. Product ID: HY-Y0873H. | |
| PEG4000-bis-amine | PEG4000-bis-amine synthesizes folate-conjugated polymeric micelles for encapsulation of the anticancer agent 9-nitrocamptothecin HY-16560 (HY-16560). Folic acid-conjugated polymer micelles are effective carriers of insoluble anticancer drugs, which can avoid macrophages and play a role in endocytosis of tumor cells mediated by folate receptors (FR). Uses: Scientific research. Category: Signaling pathways. Alternative Names: Poly(ethylene glycol)-bis-amine 4000. CAS No. 24991-53-5. Pack Sizes: 250 mg; 1 g. Product ID: HY-W115607. | |
| PEG4-aminooxy-MMAF | PEG4-aminooxy-MMAF is a agent-linker conjugate for ADC with potent antitumor activity by using the potent antitubulin agent MMAF, linked via the noncleavable PEG4[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Amberstatin; AS269. CAS No. 1415246-35-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-128968. | |
| PEG6000 | PEG6000 can be used as an excipient, such as Ointment base, lubricant, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyethylene glycol 6000. CAS No. 25322-68-3. Pack Sizes: 10 g; 25 g; 50 g; 100 g. Product ID: HY-Y0873I. | |
| PEG800 | PEG800 (Polyethylene glycol 800) is a nonionic surfactant that is soluble in water and many polar solvents[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyethylene glycol 800. CAS No. 25322-68-3. Pack Sizes: 10 mM * 1 mL in Water; 25 g; 50 g; 100 g; 500 g. Product ID: HY-Y0873L. | |
| PEG8000 | PEG8000 can be used for phage precipitation, isolation of plasmid DNA, and promotion of flat end-junction reactions[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyethylene glycol 8000. CAS No. 25322-68-3. Pack Sizes: 10 g; 25 g; 50 g; 100 g; 500 g. Product ID: HY-Y0873J. | |
| Pegaptanib sodium | Pegaptanib sodium is an RNA aptamer with polyethylene glycol modifications, which is directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) [1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EYE001; NX1838. CAS No. 222716-86-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-109561. | |
| Pegevongitide | Pegevongitide is an agonist of the angiopoietin-1 receptor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AV-001. CAS No. 2988012-71-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P10887. | |
| Peginterferon alfa-2b | Peginterferon alfa-2b (PegIFN a-2b; Sch 54031; Sylatron; ViraferonPeg) is an immunomodulator. Peginterferon alfa-2b is a recombinant alfa-2b interferon covalently linked PEG with antiviral activity against HCV. Peginterferon alfa-2b decreases viral DNA in HIV. Peginterferon alfa-2b can be used in research of melanoma and hepatitis C[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PegIFN a-2b; Sch 54031; Sylatron; ViraferonPeg. CAS No. 215647-85-1. Pack Sizes: 10 μg; 50 μg. Product ID: HY-108842. | |
| Peimine | Peimine (Verticine; Dihydroisoimperialine) is an orally active natural product. Peimine has anti-inflammatory, analgesic and cough relieving effects. Peimine can be used in cancer and inflammation related research[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Verticine; Dihydroisoimperialine. CAS No. 23496-41-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0212. | |
| Peiminine | Peiminine is a compound that can be isolated from Bolbostemma paniculatum (Maxim) Franquet (Cucurbitaceae family). Peiminine can induce apoptosis in human hepatocellular carcinoma HepG2 cells through both extrinsic and intrinsic apoptotic pathways. Peiminine has anti-inflammatory, anticancer, anti-osteoporosis, cardioprotective and other activities in many animal models[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Verticinone; Raddeanine. CAS No. 18059-10-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N0213. | |
| Pelabresib | Pelabresib (CPI-0610) is a potent, selective, orally active and cell-active BET inhibitor. Pelabresib inhibits BRD4-BD1 with an IC50 of 39 nM, and with an EC50 value of 0.18 μM for MYC[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CPI-0610. CAS No. 1380087-89-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12863. | |
| Pelacarsen | Pelacarsen (ISIS 681257) is a GalNAc3-conjugated 2-MOE-modified antisense oligonucleotide. Pelacarsen reduces apo (a)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AKCEA-APO(a)-LRx; ISIS 681257; TQJ230. CAS No. 1637637-70-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-151123. | |
| Pelargonidin chloride | Pelargonidin chloride is an anthocyanidin and also is a scavenger of nitric oxide radical and has antioxidant activities. Pelargonidin inhibits cell viability and induces cell cycle arrest at sub-G1 phase. Pelargonidin chloride increases the mRNA and protein expression of HO-1, NQO1, Nrf2. Pelargonidin chloride improves Aβ-induced memory and learning impairment[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 134-04-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-W011370. | |
| Pelcitoclax | Pelcitoclax (APG-1252) is a potent Bcl-2/Bcl-xl inhibitor with antineoplastic and pro-apoptotic effects[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: APG-1252. CAS No. 1619923-36-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109185. | |
| Pelgifatamab | Peligifatamab is a PSMA-targeted α-radioimmunoconjugate with an EC50 of 1.2 nM against human targets. Peligifatamab induces DNA damage, DNA double-strand breaks, cell cycle arrest and apoptosis (Apoptosis) in PSMA-positive prostate cancer cells. Peligifatamab reduces cell viability in a manner dependent on cellular PSMA expression levels. Peligifatamab inhibits tumor growth and tumor-induced abnormal bone growth in prostate cancer bone metastasis models. Peligifatamab exhibits antitumor efficacy in subcutaneous prostate cancer models and xenograft models. Peligifatamab can be used for the research of metastatic castration-resistant prostate cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY-2315497; PSMA-TTC. CAS No. 2414550-93-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9992. | |
| PELI1-IN-1 | PELI1-IN-1 (compound 3d) is a potent inhibitor of PELI1, E3 ubiquitin ligase. PELI1-IN-1 has anti-tumPELI1-IN-1, a Resveratrol (HY-16561) derivative, is an orally active PELI1 Inhibitor (Kd = 8.2 μM). PELI1-IN-1 markedly interrupts the interaction of PELI1 and SNAIL/SLUG, and inhibits the K63-polyubiquitization of SNAIL/SLUG by PELI1, subsequently downregulating the protein levels of epithelial-mesenchymal transition (EMT) effectors SNAIL/SLUG. PELI1-IN-1 significantly reduces the level of SNAIL, SLUG and Vimentin without affecting the PELI1 expression. PELI1-IN-1 targets the FHA domain of PELI1 and disrupts the interaction, leading to the anti-metastasis of TNBC cells in vitro and in vivo. PELI1-IN-1 shows no evident toxicity in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3034889-94-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-157435. | |
| Pelitinib | Pelitinib (EKB-569;WAY-EKB 569) is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282, 800, and 1255 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EKB-569; WAY-EKB 569. CAS No. 257933-82-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-32718. | |
| Pe litrexol | Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), a purine biosynthetic enzyme. Pelitrexol also inhibits mTORC1 by reducing GTP-bound Rheb level, a mTORC1 obligate activator. Pelitrexol shows robust tumor growth suppression in mice[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AG 2037. CAS No. 446022-33-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14530. | |
| Pellitorine | Pellitorine is a bioactive natural amide compound. Pellitorine can competitively antagonize the activation of TRPV1 by Capsaicin (HY-10448), thereby reducing pain signal transmission. Pellitorine improves cognitive dysfunction by upregulating the BDNF-ERK1/2-CREB and Nrf2-HO-1 pathways. Pellitorine exerts anti-inflammatory and anti-sepsis effects by inhibiting the release of high mobility group protein B1 (HMGB1) and the expression of RAGE/TLR4. Pellitorine exerts its antithrombotic effect by prolonging the clotting time, inhibiting the activity of clotting factors and thrombin. Pellitorine inhibits lipid peroxidation and resists ferroptosis by upregulating GPX4 and DHODH. Pellitorine kills Aedes aegypti mosquito larvae by inhibiting V-type H?-ATPase and aquaporin 4 (AaAQP4). Pellitorine exhibits anti-cancer activity (e.g., leukemia and breast cancer) and has inhibitory effects on certain bacteria[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 18836-52-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N3097. | |
| Pemafibrate | Pemafibrate is a highly selective PPARα agonist, with an EC50 of 1 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-K-13675. CAS No. 848259-27-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17618. | |
| Pembrolizumab | Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 (PD-1) receptor, used in cancer immunotherapy. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-3475; Lambrolizumab. CAS No. 1374853-91-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P9902. | |
| Pemetrexed | Pemetrexed (LY231514) is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY231514. CAS No. 137281-23-3. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10820. | |
| Pemetrexed disodium | Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY231514 disodium. CAS No. 150399-23-8. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg; 200 mg. Product ID: HY-10820A. | |
| Pemetrexed disodium hemipenta hydrate | Pemetrexed (LY231514) disodium hemipenta hydrate is a CNS-penetrant antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY231514 disodium hemipenta hydrate. CAS No. 357166-30-4. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg. Product ID: HY-13781. | |
| Pemetrexed disodium heptahydrate | Pemetrexed disodium heptahydrate is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY231514 disodium heptahydrate. CAS No. 357166-29-1. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg. Product ID: HY-10820B. | |
| Pemetrexed (Standard) | Pemetrexed (Standard) is the analytical standard of Pemetrexed. This product is intended for research and analytical applications. Pemetrexed (LY231514) is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY231514 (Standard). CAS No. 137281-23-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10820R. | |
| Pemigatinib | Pemigatinib (INCB054828) is an orally active, selective FGFR inhibitor with IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively. Pemigatinib has the potential for cholangiocarcinoma[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INCB054828. CAS No. 1513857-77-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-109099. | |
| Pemirolast potassium | Pemirolast potassium is an orally active antiallergic agent. Pemirolast potassium attenuates Paclitaxel (HY-B0015) hypersensitivity reactions. Pemirolast potassium can be used for bronchial asthma and conjunctivitis research[1]-[5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TWT-8152; BMY 26517. CAS No. 100299-08-9. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0538A. | |
| Pemivibart | Pemivibart is an anti-SARS-CoV-2 human IgG1 λ2 monoclonal antibody[1]. Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096). Uses: Scientific research. Category: Signaling pathways. CAS No. 2858673-18-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990756. | |
| Pemvidutide | Pemvidutide (ALT-801) is a GLP-1R/GCGR dual agonist, shows striking reductions in body weight, liver fat and serum lipids. Pemvidutide can be used in non-alcoholic steatohepatitis (NASH) and obesity research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALT-801. CAS No. 2538014-94-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-145632. | |
| PENAO | PENAO is a potent tumour cell mitochondrial toxin. PENAO inactivates tumor cell mitochondria by targeting inner-membrane adenine nucleotide transferase[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1192411-43-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-16386. | |
| Penciclovir | Penciclovir (VSA 671) is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 μg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir shows anti-herpesvirus activity with no-toxic. Penciclovir preventes mortality in mouse[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BRL 39123; VSA 671. CAS No. 39809-25-1. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-17424. | |
| Penciclovir (Standard) | Penciclovir (Standard) is the analytical standard of Penciclovir. This product is intended for research and analytical applications. Penciclovir (VSA 671) is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 μg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir shows anti-herpesvirus activity with no-toxic. Penciclovir preventes mortality in mouse[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BRL 39123 (Standard); VSA 671 (Standard). CAS No. 39809-25-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-17424R. | |
| Pencycuron-d5 | Pencycuron-d5 is the deuterium labeled Pencycuron (HY-B2048). Pencycuron is a benzoylurea fungicide. Pencycuron kills fungi by inhibiting the synthesis of fungal cell walls.Pencycuron can be used in research on the control of fungal diseases on crops, such as sheath blight, powdery mildew and late blight[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 83286-58-2. Pack Sizes: 1 mg. Product ID: HY-B2048S. | |
| Penetratin | Penetratin is a cell-penetrating peptides derived from a nonviral protein. Penetratin can powerfully enhance drug absorption. Penetratin can be used for drug delivery research in the treatment of various diseases[1][2]. Uses: Scientific research. Category: Peptides. CAS No. 940866-75-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2529. | |
| Penflufen | Penflufen is a highly efficient, broad-spectrum succinate dehydrogenase inhibitor (SDHI). Penflufen can be used as a fungicide and has broad bioactivity against many fungal diseases, including potato black scurf, wheat sharp eyespot, rice sheath blight, and root rot in peanut and other similar fungal diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 494793-67-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139161. | |
| Penfluridol | Penfluridol (R-16341) is a potent, long-acting, first-generation, oral diphenylbutylpiperidine antipsychotic agent by targeting D2-like dopamine receptor. Penfluridol effectively inhibits TNFα-induced NF-κB activation and alleviates the severity of arthritis and colitis in vivo. Penfluridol is a Ca2+-calmodulin inhibitor. Penfluridol induces apoptosis and autophagy. Penfluridol is used for chronic schizophrenia, acute psychosis, Tourette syndrome and autoimmune diseases. Penfluridol inhibites the growth of E. faecalis planktonic cells with the MIC of 7.81 μg/ml[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R-16341. CAS No. 26864-56-2. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-B1077. | |
| PEN (human) | PEN (human), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 597578-70-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2278. | |
| Penicillic acid | Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 90-65-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N6777. | |
| Penicillin amidase, E. coli (Immobilized) | Penicillin amidase, E. coli (Immobilized) (PGA) is an amidohydrolase commonly used in industrial biocatalysis. Penicillin amidase, E. coli (Immobilized) serves as a starting material in the synthesis of semi-synthetic penicillins. Penicillin amidase, E. coli (Immobilized) promotes the production of semi-synthetic β-lactam antibiotics, participates in peptide synthesis, and catalyzes the formation of chiral compounds. Penicillin amidase, E. coli (Immobilized) is regulated by temperature and phenylacetic acid in E. coli. In free E. coli, it participates in the assimilation of aromatic compounds as a carbon source. Penicillin amidase, E. coli (Immobilized) is hypothesized to act as a scavenging enzyme for phenylacetyl-containing compounds in microbial metabolism and is associated with bacterial quorum sensing[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PGA. CAS No. 9014-6-6. Pack Sizes: 100 mg; 250 mg. Product ID: HY-P2834. | |
| Penicillin G-d7 potassium salt | Penicillin G-d7 (potassium) is the deuterium labeled Penicillin G potassium salt[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Benzylpenicillin-d7 potassium salt. CAS No. 352323-25-2. Pack Sizes: 2.5 mg. Product ID: HY-N7139S1. | |
| Penicillin G potassium | Penicillin G potassium is a fast-acting penicillin family antibiotic. Penicillin G potassium can be used for the research of bacterial infections that affect the blood, heart, lungs, joints, and genital areas[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Benzylpenicillin potassium. CAS No. 113-98-4. Pack Sizes: 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-17591. | |
| Penicillin G sodium salt | Penicillin G sodium salt is a typical β-lactam antibiotic. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Benzylpenicillin sodium salt. CAS No. 69-57-8. Pack Sizes: 100 mg; 250 mg; 500 mg. Product ID: HY-B1463. | |
| Penicillin V | Penicillin V (Phenoxymethylpenicillin) is a potent and orally active antibiotic. Penicillin V shows antibacterial activity for Streptococci, Clostridium difficile and staphylococcus aureus. Penicillin V has the potential for the research of otitis, sinusitis, pharyngitis and tonsillitis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Phenoxymethylpenicillin. CAS No. 87-08-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0975A. | |
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