MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| PC Biotin-PEG3-azide | PC Biotin-PEG3-azide is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. PC Biotin-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1937270-46-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-140132. |  |
| PC Biotin-PEG3-NHS ester | PC Biotin-PEG3-NHS ester is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2353409-93-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-140134. | |
| PCC0208009 | PCC0208009 is a potent IDO inhibitor with an IC50 value of 4.52 nM in HeLa cell. PCC0208009 alleviates neuropathic pain and comorbidities by regulating synaptic plasticity of anterior cingulate cortex (ACC) and amygdala [1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1668565-74-9. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100771. | |
| PCC0208017 | PCC0208017 is a microtubule affinity regulating kinases (MARK3/MARK4) inhibitor with IC50s of 1.8 and 2.01 nM, respectively. PCC0208017 has much lower inhibitory activity against MARK1 and MARK2, with IC50s of 31.4 and 33.7 nM, respectively. PCC0208017 suppresses glioma progression in vitro and in vivo. PCC0208017 disrupts microtubule dynamics and induces G2/M phase cell cycle arrest and cell apoptosis. PCC0208017 demonstrates robust antitumor activity in vivo and displays good BBB permeability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2623158-64-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139604. | |
| PC DBCO-PEG4-NHS ester | PC DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PC DBCO-PEG4-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2055025-02-8. Pack Sizes: 10 mg; 25 mg. Product ID: HY-138756. | |
| PCI-33380 | PCI-33380 is a fluorescent probe ( (Ex=532 nm, Em=555 nm). PCI-33380 consists of a (BTK) inhibitor PCI-32765 (HY-10997) attaching with a Bodipy-FL fluorophore via a piperazine linker. PCI-33380 binds predominantly to Btk in B cell lysates with cell permeable activity. PCI-33380 can be used for imaging live cancer cells such as non-Hodgkin lymphoma research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1022899-36-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100335. | |
| PCI-34051 | PCI-34051 is a potent and selective HDAC8 inhibitor with IC50 of 10 nM, with >200-fold selectivity over the other HDAC isoforms. Uses: Scientific research. Category: Signaling pathways. CAS No. 950762-95-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15224. | |
| PCO371 | PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor. Uses: Scientific research. Category: Signaling pathways. CAS No. 1613373-33-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-100856. | |
| p-Coumaric acid | p-Coumaric acid (trans-4-Hydroxycinnamic acid) is an isomer of cinnamic acid with oral activity. p-Coumaric acid inhibits cell proliferation and promotes apoptosis. p-Coumaric acid has antibacterial, anti-inflammatory, antioxidant and anti-tumor activities[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: trans-4-Hydroxycinnamic acid. CAS No. 501-98-4. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-N0351. | |
| p-Coumaric acid-d6 | p-Coumaric acid-d6 is the deuterium labeled p-Coumaric acid (HY-N0351). p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: trans-4-Hydroxycinnamic acid-d6. CAS No. 2708298-33-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N0351S1. | |
| p-Coumaroyl-CoA | p-Coumaroyl-CoA (4-Coumaroyl-CoA; p-coumaroylcoenzyme A) is a coenzyme A derivative. p-Coumaroyl-CoA serves as a key intermediate in the biosynthesis of lignin and flavonoids[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4-Coumaroyl-CoA; p-coumaroylcoenzyme A. CAS No. 30802-00-7. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N11658. | |
| PCPA methyl ester hydrochloride | PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride), a reversible tryptophan hydroxylase inhibitor, is a serotonin (5-HT) synthesis inhibitor. PCPA methyl ester hydrochloride crosses the blood brain barrier and reduces 5-HT central availability[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4-Chloro-DL-phenylalanine methyl ester hydrochloride. CAS No. 14173-40-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g. Product ID: HY-101456. | |
| p-Cresol glucuronide | p-Cresol glucuronide, a metabolite of p-cresol, is a prototype protein-bound uremic toxin. p-Cresol glucuronide is associated with chronic kidney disease (CKD)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 17680-99-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W416250. | |
| p-Cresol sulfate-d7 potassium | p-Cresol sulfate-d7 (potassium) is the deuterium labeled p-Cresyl sulfate potassium. p-Methylphenyl potassium sulfate is a prototype protein-bound uremic toxin[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: p-Tolyl sulfate-d7 potassium. CAS No. 2469278-96-2. Pack Sizes: 5 mg. Product ID: HY-111431AS. | |
| p-Cresyl sulfate | p-Cresyl sulfate (p-Tolyl sulfate) is a uremic toxin, that can cause renal damage and dysfunction. p-Cresyl sulfate shows antiproliferation activity. p-Cresyl sulfate increases the protein expression of HIF-1α and VHL, decreases the protein expression of HIF-2α. p-Cresyl sulfate induces epithelial-mesenchymal transition (EMT). p-Cresyl sulfate activates the JNK and p38 MAPK signaling pathways[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: p-Tolyl sulfate. CAS No. 3233-58-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-111431. | |
| p-Cresyl sulfate potassium | p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: p-Tolyl sulfate potassium. CAS No. 91978-69-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg. Product ID: HY-111431A. | |
| p-Cresyl sulfate potassium (Standard) | p-Cresyl sulfate (potassium) (Standard) is the analytical standard of p-Cresyl sulfate (potassium). This product is intended for research and analytical applications. p-Cresyl sulfate (p-Tolyl sulfate) potassium is a uremic toxin, that can cause renal damage and dysfunction. p-Cresyl sulfate potassium shows antiproliferation activity. p-Cresyl sulfate potassium increases the protein expression of HIF-1α and VHL, decreases the protein expression of HIF-2α. p-Cresyl sulfate potassium induces epithelial-mesenchymal transition (EMT). p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: p-Tolyl sulfate potassium (Standard). CAS No. 91978-69-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111431AR. | |
| PCSK9-IN-29 | PCSK9-IN-29 is a lipid-lowering agent. PCSK9-IN-29 can increase low-density lipoprotein receptor (LDLR) protein expression and decrease PCSK9 protein expression in hepG2 cells. PCSK9-IN-29 can reduce the levels of serum LDL-C, TC, and liver enzyme ALT in crab eating macaques fed a high-fat diet, lower body weight and fat, and increase bone mineral content. PCSK9-IN-29 can be used for research on non-alcoholic fatty liver disease and obesity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1233353-86-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-159595. | |
| PD0166285 | PD0166285, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 exhibits an IC50 of 3.433 μM for Chk1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 185039-89-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13925. | |
| PD 102807 | PD 102807 is a M4 muscarinic receptor antagonist with an IC50 of 90.7 nM. PD 102807 inhibits M1, M2, M3, M5 muscarinic receptor with IC50s of 6558.7, 3440.7, 950.0, and 7411.7 nM, respectively[1]. Antidyskinetic effect. Uses: Scientific research. Category: Signaling pathways. CAS No. 23062-91-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-107646. | |
| PD-118057 | PD-118057 is a hERG channel activator without causing hERG blockade. PD-118057 activates hERG channel to suppress changes in membrane excitability[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 313674-97-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108594. | |
| PD 123319 ditrifluoroacetate | PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 136676-91-0. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10259A. | |
| PD 128042 | PD 128042 (CI 976) is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC50s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC50=15 μM). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CI 976. CAS No. 114289-47-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107572. | |
| (+)-PD 128907 hydrochloride | (+)-PD 128907 hydrochloride is a selective dopamine D2/D3 receptor agonist, with Kis of 1.7, 0.84 nM for human and rat D3 receptors, 179, 770 n M for human and rat D3 receptors, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 300576-59-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110000. | |
| PD 144418 | PD 144418 is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 shows potential antipsychotic activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 154130-99-1. Pack Sizes: 2 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-108512. | |
| PD146176 | PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC168807. CAS No. 4079-26-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103157. | |
| PD150606 | PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor with Ki values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 179528-45-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-100529. | |
| PD 151746 | PD151746 is a calpain inhibitor, shows a 20-fold selectivity for u-calpain (Ki = 0. Uses: Scientific research. Category: Signaling pathways. CAS No. 181765-30-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19749. | |
| PD153035 | PD153035 (SU-5271; AG1517; ZM 252868) is a potent EGFR inhibitor with Ki and IC50 of 6 and 25 pM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SU-5271; AG1517; ZM 252868. CAS No. 153436-54-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14346. | |
| PD158780 | PD158780 is a potent EGFR family inhibitor with IC50s of 8 pM, 49, 52, 52 nM for EGFR, ErbB2, ErbB3, and ErbB4, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 171179-06-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-18609. | |
| PD-166866 | PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC50 of 52.4 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 192705-79-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-101296. | |
| PD 168368 | PD 168368 is a potent, competitive, and selective neuromedin B receptor (NMB-R) antagonist with the Ki of 15-45 nM[1]. PD 168368 is neuromedin B receptor (NMBR; IC50=96 nM) / gastrin-releasing peptide receptor (GRPR IC50=3500 nM) antagonist[2]. PD 168368 also is a mixed FPR1/FPR2/FPR3 agonist with EC50s of 0.57, 0.24, and 2.7 nM, respectively[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 204066-82-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116216. | |
| PD168393 | PD168393 is a potent, selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2. PD168393 irreversiblely inactivates EGF receptor ( IC50=0.7 nM) and is inactive against insulin receptor, PDGFR, FGFR and PKC[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 194423-15-9. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13896. | |
| PD 168568 dihydrochloride | PD 168568 dihydrochloride is a orally active and potent dopamine receptor D4 (DRD4) antagonist. PD 168568 dihydrochloride contains an isoindolinone and is selective for the D4 receptor versus D2 and D3, with Ki values of 8.8, 1842, and 2682 nM, respectively. PD 168568 dihydrochloride can be used for glioblastoma (GBM) research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1782532-06-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-103407A. | |
| PD 169316 | PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM. PD169316 selectively inhibits the kinase activity of the phosphorylated p38 without hindering upstream kinases to phosphorylate p38. PD169316 shows antiviral activity against Enterovirus71. PD169316 shows antiviral activity against Enterovirus71. Uses: Scientific research. Category: Signaling pathways. CAS No. 152121-53-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10578. | |
| PD173074 | PD173074 is a potent FGFR1 inhibitor with an IC50 of 25 nM and also inhibits VEGFR2 with an IC50 of 100-200 nM, showing 1000-fold selectivity for FGFR1 over PDGFR and c-Src. Uses: Scientific research. Category: Signaling pathways. CAS No. 219580-11-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10321. | |
| PD173212 | PD173212 is a selective N-type voltage sensitive calcium channel (VSCC) blocker, with an IC50 of 36 nM in IMR-32 assays. Uses: Scientific research. Category: Signaling pathways. CAS No. 217171-01-2. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103318. | |
| PD173952 | PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 305820-75-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122113. | |
| PD173955 | PD173955 is an orally active inhibitor of Src (IC50= 22 nM), Yes, Abl, ATP and MAP kinases. PD173955 can effectively prevent the mitotic process and has anticancer activity[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 260415-63-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10395. | |
| PD 174265 | PD 174265 is a highly selective, reversible EGFR/ErbB2 tyrosine kinase inhibitor (IC50=0.45 nM) and cell differentiation inducer. By blocking receptor autophosphorylation and the downstream ERK signaling pathway (with an IC50 of 0.45 μM for full-length ERK), PD 174265 effectively inhibits tumor growth and exhibits antitumor activity without obvious toxicity in in vivo models. PD 174265 drives oligodendrocyte precursor cells to switch from a proliferative state to a differentiated state, significantly upregulates the expression of myelin proteins such as CNP, PLP and MBP, and induces neurite branching. PD 174265 shows no inhibitory effect on other kinases including insulin, PDGF and basic FGF receptors, and serves as a crucial tool molecule for investigating the treatment of human epidermoid carcinoma and the mechanism of myelin repair in multiple sclerosis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 216163-53-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112411. | |
| PD176252 | PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 μM in HL-60 cells. Uses: Scientific research. Category: Signaling pathways. CAS No. 204067-01-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103286. | |
| PD180970 | PD180970 is a highly potent and ATP-competitive p210Bcr-Abl kinase inhibitor, with an IC50 of 5 nM for inhibiting the autophosphorylation of p210Bcr-Abl. PD180970 also inhibits Src and KIT kinase with IC50s of 0.8 nM and 50 nM, respectively. PD180970 indcues apoptosis of K562 leukemic cells, and can be used for chronic myelogenous leukemia research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 287204-45-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103274. | |
| PD 198306 | PD 198306 is a selective MAPK/ERK-kinase (MEK) inhibitor. PD 198306 results in an observable reduction in the Streptozocin induced increase in the level of active ERK1 and 2. Antihyperalgesic effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 212631-61-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107620. | |
| PD-1/PD-L1-IN-29 | PD-1/PD-L1-IN-29 (S4-1) is a potent PD-1/PD-L1 inhibitor with an IC50 value of 6.1 nM. PD-1/PD-L1-IN-29 binds PD-L1 and disrupts PD-1/PD-L1 interactions, induces PD-L1 dimerization and internalization, improves its localization to the endoplasmic reticulum, and promotes PD-L1 entry into the endoplasmic reticulum. PD-1/PD-L1-IN-29 has anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2665734-13-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-152240. | |
| PD318088 | PD318088 is a potent, allosteric and non-ATP competitive MEK1/2 inhibitor, an analog of PD184352 (HY-50295). PD318088 binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. PD318088 can be used for cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 391210-00-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12062. | |
| PD 407824 | PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 622864-54-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18961. | |
| PD 90780 | PD 90780 is a non peptide antagonist of nerve growth factor (NGF). PD 90780 interacts with NGF, prevents NGF binds with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 77422-99-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110166. | |
| PD98059 | PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 μM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 μM) and MEK2 (IC50 of 50 μM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 167869-21-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12028. | |
| PDC31 | PDC31 (THG113.31; ILGHXDYK) is an allosteric and non-competitive inhibitor of FP Prostaglandin Receptor. PDC31 is the D-amino acid-based oligopeptide, is used for smooth muscle contractile agent. PDC31 decreases the strength and duration of uterine contractions in vivo, which can be used for research of preterm labor and primary dysmenorrhea (PD). PDC31 also enhances Ca2+-dependent large-conductance K+-channel in human myometrial cells[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: THG113.31; ILGHXDYK. CAS No. 634586-40-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4160. | |
| PdCl2(Amphos)2 | PdCl2(Amphos)2 is a highly efficient palladium catalyst. PdCl2(Amphos)2 can be used in research related to organic synthesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 887919-35-9. Pack Sizes: 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-W010686. | |
| PDD00017272 | PDD00017272 is an inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (EC50=4.8 nM) and an activator of PARP1/2. PDD00017272 inhibits its activity of hydrolyzing poly(ADP-ribose) (pADPr), resulting in the accumulation of pADPr on chromatin, interfering with DNA damage repair and replication processes, and inducing PARP1/2-dependent cytotoxicity. PDD00017272 can be used in cancer models with DNA repair defects (such as BRCA mutations) or resistance to PARP inhibitors. PDD00017272 has a PARG expression level-correlated inhibitory potency with EC50 of 9.2 nM (PARG cells), the tumor cells with lower PARG expression are more sensitive[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1945950-20-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133531. | |
| PDD 00017273 | PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC50 of 26 nM, and a KD of 1.45 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1945950-21-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-108360. | |
| PDE10-IN-5 | PDE10-IN-5 is a phosphodiesterase 10 (PDE 10) inhibitor, can be used for researching certain central nervous system (CNS) disorders[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 898562-99-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14550A. | |
| PDE12-IN-1 | PDE12-IN-1 is a potent and selective PDE12 inhibitor with a pIC50 value for enzyme inhibition of 9.1. PDE12-IN-1 increases 2,5-linked adenylate polymers (2-5A) levels, and the pEC50 value is 7.7. PDE12-IN-1 shows antiviral activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2259620-80-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117318. | |
| PDE4B-IN-2 | PDE4B-IN-2 is an orally active and selective PDE4B inhibitor with an IC50 of 15 nM. PDE4B-IN-2 inhibits PDE4D (IC50=1.7 μM). PDE4B-IN-2 exhibits potent anti-inflammatory effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 915082-52-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115687. | |
| PDE4B modulator-1 | PDE4B modulator-1 is a PDE4B modulator. Uses: Scientific research. Category: Signaling pathways. CAS No. 848057-26-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-180878. | |
| PDE4-IN-24 | PDE4-IN-24 (compoud 14h) is a potent inhibitor of PDE4D with the IC50 of 0.57 nM and >4100-fold selectivity over other PDE families. PDE4-IN-24 plays an important role in inflammatory disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3087059-29-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-169981. | |
| PDE5-IN-4 | PDE5-IN-4 is a phosphodiesterase 5 inhibitor. PDE5-IN-4 can be used for the research of acute myocardial infarction and damage caused by reperfusion, gastrointestinal diseases, damage caused by diabetes, and liver failure[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 224788-36-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-142059. | |
| PDE7A-IN-1 | PDE7A-IN-1 is an orally active and selective PDE7A inhibitor with an IC50 of 0.0037 μM against PDE7A. PDE7A-IN-1 shows excellent isozyme selectivity over PDE7B. PDE7A-IN-1 elevates intracellular cAMP levels, suppresses ECR5 enhancer activity and reduces sclerostin expression. PDE7A-IN-1 significantly increases bone mineral density in rats. PDE7A-IN-1 can be used for the study of osteoporosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3074559-75-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-170788. | |
| PDE7-IN-3 | Pde7-in-3 (example 2) is an inhibitor of the phosphodiesterase PDE7 with potential analgesic activity. PDE7-IN-3 can be used to study inflammatory, neuropathic, visceral and nociceptive pain[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 908570-13-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100326. | |
| PDEC-NB | PDEC-NB is a disulfide cleavable linker used for the antibody-drug conjugate (ADC). Uses: Scientific research. Category: Signaling pathways. CAS No. 874302-76-8. Pack Sizes: 100 mg; 250 mg; 1 g; 5 g. Product ID: HY-126498. | |
| PDGFRα kinase inhibitor 1 | PDGFRα kinase inhibitor 1 is a highly selective type II PDGFRα kinase inhibitor with IC50s of 132 nM and 6115 nM for PDGFRα and PDGFRβ, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2209053-93-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111507. | |
| PDHK-IN-4 | PDHK-IN-4 (Compound 30) is a potent inhibitor of PDHK with IC50s of 0.0051 and 0.0122 μM for PDHK2 and PDHK4, repectively. Pyruvate dehydrogenase kinases (PDHKs) are fascinating agent targets for numerous diseases, including diabetes and cancers. PDHK-IN-4 has the potential for the research of cancer diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3065641-69-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-146552. | |
| PDI2 | PDI2 (PSMA-DOTA-PEI2) is a prostate-specific membrane antigen (PSMA) ligand that acts as a tumor retention agent, renal uptake reducer, imaging agent and antitumor agent, applicable in SPECT diagnostic imaging and radiotheranostics. PDI2 specifically binds to PSMA on prostate cancer cells, enters cells via clathrin-dependent endocytosis, and exhibits higher tumor retention rate and lower renal uptake level. PDI2 is applicable in research related to prostate cancer and castration-resistant metastatic prostate cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PSMA-DOTA-PEI2. CAS No. 3110124-60-9. Pack Sizes: 100 μg; 500 μg; 1 mg; 5 mg. Product ID: HY-P11591. | |
| PDI-IN-3 | PDI-IN-3 (compound 16F16) is a protein disulfide isomerase (PDI) inhibitor. PDI-IN-3 inhibits cell viability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 922507-80-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-124866. | |
| PDK4-IN-1 | PDK4-IN-1 is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 has antidiabetic, anticancer and anti-allergic activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2310262-10-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-135954. | |
| PDK4-IN-1 hydrochloride | PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 hydrochloride potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 hydrochloride has antidiabetic, anticancer and anti-allergic activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2310262-11-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-135954A. | |
| PDK-IN-1 | PDK-IN-1 (compound 7o) is a pyruvate dehydrogenase kinase (PDK) inhibitor. PDK-IN-1 shows IC50 values of 0.03 and 0.1 μM for PDK1 and HSP90, respectively. PDK-IN-1 targets PDH/PDK axis thus reducing efficiently the tumor mass[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2897696-10-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149814. | |
| PDMP hydrochloride | PDMP hydrochloride is a glucosylceramide synthase (GCS) inhibitor. PDMP hydrochloride induces apoptosis in K562/A02 cells. PDMP hydrochloride can be used in cancer (such as leukemia) research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 73257-80-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-116392D. | |
| PDRN | PDRN (Polydeoxyribonucleotide) is a linear polyribonucleotide fragment mainly derived from salmon sperm. PDRN exhibits antioxidant and anti-aging properties by diminishing autophagy and enhancing SIRT1 expression. PDRN shows tissue regeneration and anti-inflammatory effects[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polydeoxyribonucleotide. CAS No. 100403-24-5. Pack Sizes: 250 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-W250160. | |
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