MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Pariceract | Pariceract (LTI-291) is an activator of glucocerebrosidase (Gcase), with activation rates of more than 60% (1 μM) and between 10%-20% (0.1 μM). Pariceract can be used for Parkinson's disease and endometriosis research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LTI-291; BIA 28-6156. CAS No. 1919820-28-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104038. |  |
| Paridiprubart | Paridiprubart (NI-0101) is a humanised anti-TLR4 monoclonal antibody. Paridiprubar inhibits the production of pro-inflammatory cytokines by monocytes from rheumatoid arthritis specimen induced by rheumatoid arthritis synovial fluid (RASF). Paridiprubart can be used for the study of rheumatoid arthritis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NI-0101. CAS No. 2641646-59-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-145645. | |
| Parishin B | Parishin B is a parishin metabolite that can be isolated from Gastrodia elata with antioxidant activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 174972-79-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N2124. | |
| Paris saponin VII | Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Chonglou Saponin VII. CAS No. 68124-04-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N3584. | |
| Paritaprevir | Paritaprevir (ABT-450) is a potent, orally active and antiviral non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50s of 1 and 0.21 nM against HCV 1a and 1b, respectively. Paritaprevir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.31 μM. Paritaprevir is metabolized primarily by cytochrome P450 (CYP) 3A. The plasma concentration and half-life of Paritaprevir can be enhanced by Ritonavir (a CYP450 inhibitor)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-450; Veruprevir. CAS No. 1216941-48-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12594. | |
| PARL-IN-2 | PARL-IN-2 (Compound 14) is a covalent inhibitor of the mitochondrial intramembrane protease PARL with an EC50 value of 0.16 μM. PARL-IN-2 leads to a robust activation of the PINK1/Parkin pathway. PARL-IN-2 promotes PINK1/Parkin-dependent mitophagy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3099681-58-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-169380. | |
| Parmodulin 2 | Parmodulin 2 (ML161) is an allosteric inhibitor of protease-activated receptor 1 (PAR1) with an IC50 of 0.26 μM[1]. Parmodulin 2 is a potent and non-competitive inhibitor of SFLLRN-induced P-selectin expression leading to inhibition of platelet aggregation in vitro and platelet thrombus formation in vivo[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ML161. CAS No. 423735-93-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13965. | |
| Paromomycin sulfate | Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrum aminoglycoside antibiotic with amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis by specifically binds to the RNA oligonucleotide at the A site of bacterial 30S ribosomes. Paromomycin sulfate can be used for the research of bacterial and parasitic infections[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Aminosidine sulfate. CAS No. 1263-89-4. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0956. | |
| Paroxetine | Paroxetine is an oral | |
| Paroxetine hydrochloride | Paroxetine hydrochloride is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an GRK2 inhibitor with IC50 of 14?μM. Paroxetine hydrochloride can be used for the research of depressive disorder[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BRL29060 hydrochloride; BRL29060A. CAS No. 78246-49-8. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B0492. | |
| Paroxetine hydrochloride hemihydrate | Paroxetine hydrochloride hemihydrate is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC50 of 14 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BRL29060 hydrochloride hemihydrate; BRL29060A hemihydrate. CAS No. 110429-35-1. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0492A. | |
| PARP10/15-IN-1 | PARP10/15-IN-1 (compound 8l) is a potent inhibitor of dual inhibitor of PARP10 and PARP15, with IC50s of 160 nM and 370 nM, respectively. PARP10/15-IN-1 can be used for cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2892065-01-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143398. | |
| PARP11 inhibitor ITK7 | PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor. PARP11 inhibitor ITK7 can potently inhibit PARP11 with an IC50 value of 14 nM. PARP11 inhibitor ITK7 can be used for the research of cellular localization[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ITK7. CAS No. 2411890-36-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125218. | |
| PARP1/2/TNKS1/2-IN-1 | PARP1/2/TNKS1/2-IN-1 (Compound I-9) is a dual PARP-1, PARP-2, TNKS1 and TNKS2 inhibitor with IC50 values of 0.25 nM, 1.2 nM, 13.5 nM and 4.15 nM against PARP-1, PARP-2, TNKS1 and TNKS2, respectively. PARP1/2/TNKS1/2-IN-1 exhibits favorable synergistic antitumor efficacy and induces apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2243453-32-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-146336. | |
| PARP14 inhibitor H10 | PARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC50=490 nM), over other PARPs (?24 fold over PARP1). PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2084811-68-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117889. | |
| PARP-1-IN-2 | PARP-1-IN-2 (compound 11g) is a potent PARP1 inhibitor, with an IC50 of 149 nM, and ADME prediction indicates it has high blood-brain barrier permeability. PARP1-IN-2 shows significantly potent anti-proliferative activity against Human lung adenocarcinoma epithelial cell line A549. PARP1-IN-2 can induce A549 cells apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 684234-55-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-147027. | |
| PARP1-IN-56 | PARP1-IN-56 (Compound RCY) is an I-labeled poly(ADP-ribose) polymerase (PARP1) inhibitor. PARP1-IN-56 can be radiolabeled with 211At or 125I for use as an α-emitting radiotherapeutic agent. PARP1-IN-56 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1574367-80-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-182499. | |
| PARP7-IN-15 | PARP7-IN-15 is an orally active and selective PARP7 inhibitor with an IC50 of 0.56 nM. PARP7-IN-15 inhibits the enzymatic activity of PARP7 and induces anti-tumor activity against lung cancer in vivo. PARP7-IN-15 can be used for the research of lung cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2819998-97-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155351. | |
| PARP7-IN-16 free base | PARP7-IN-16 free base is the free base form of PARP7-IN-16 (HY-156419). PARP7-IN-16 free base is a selective and orally active inhibitor of PARP-1/2/7, with IC50s of 0.94, 0.87 and 0.21 nM, respectively. PARP7-IN-16 can be used for the research of breast cancer and prostate cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2136325-05-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156419A. | |
| PARP7-IN-17 | PARP7-IN-17 is a potent inhibitor of PARP7 with IC50 of 4.5 nM that has oral bioavailability. PARP7-IN-17 displays antitumor effect[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3024030-10-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-163081. | |
| PARP7-IN-22 | PARP7-IN-22 (XLY-1) is a PARP7 inhibitor with an IC50 of 0.6 nM. PARP7-IN-22 (XLY-1) is orally active, enhances type I interferon signaling in vitro, restores type I interferon signaling, promotes T cell infiltration into tumor tissues, and significantly inhibits tumor growth. PARP7-IN-22 shows promise for research in the field of cancer immunotherapy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2946705-91-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-163719. | |
| PARPi-FL | PARPi-FL (Olaparib-bodipy FL) is a small-molecule fluorescent inhibitor of PARP1 that can specifically bind to PARP1. PARPi-FL can be used as a fluorescent imaging agent for tumor detection, diagnosis, and surgical guidance[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Olaparib-bodipy FL. CAS No. 1380359-84-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120115. | |
| PARPYnD | PARPYnD is a PARP enzyme photoaffinity probe (AfBP) based on the triple PARP1/2/6 inhibitor AZ9482 (HY-119653), which induces breast cancer Formation of multipolar spindles (MPS) in cells. PARPYnD inhibits PAPR wih IC50 of 38 nM (PARP1), 6 nM (PARP2), 230 nM (PARP6), respectively. PARPYnD enriches recombinant PARP6 incorporated into cell lysates and inhibits PARP6 in cell-free assays, but it does not label PARP6 in intact cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2561483-27-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-145749. | |
| Parsaclisib | Parsaclisib (INCB050465) is a potent, selective and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib can be used for the research of relapsed or refractory B-cell malignancies[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INCB050465; IBI-376. CAS No. 1426698-88-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109068. | |
| Parsaclisib hydrochloride | Parsaclisib hydrochloride (INCB050465 hydrochloride) is a potent, selective and orally active inhibitor of PI3Kδ, with an IC50 of 1 nM at 1 mM ATP. Parsaclisib hydrochloride shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib hydrochloride can be used for the research of relapsed or refractory B-cell malignancies[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INCB050465 hydrochloride; IBI-376 hydrochloride. CAS No. 1995889-48-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109068A. | |
| Parsatuzumab | Parsatuzumab (Anti-EGFL7; RG 7414) is a humanized monoclonal antibody, acts as an immunomodulator and binds to EGFL7. Parsatuzumab selectively blocks the interaction between EGFL7 and endothelial cells, potentially inhibiting vascular regrowth and reducing vascular endothelial growth factor (VEGF) inhibition[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-EGFL7; RG 7414. CAS No. 1312797-14-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99215. | |
| Parthenolide | Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Parthenolide. CAS No. 20554-84-1. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-N0141. | |
| Parthenolide (Standard) | Parthenolide (Standard) is the analytical standard of Parthenolide. This product is intended for research and analytical applications. Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Parthenolide (Standard). CAS No. 20554-84-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0141R. | |
| Pascolizumab | Pascolizumab (SB-240683) is a humanized anti-IL-4 monoclonal antibody. Pascolizumab has the potential for the research of asthma[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: SB-240683. CAS No. 331243-22-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P99801. | |
| Pasireotide | Pasireotide (SOM230), a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide also exhibits antisecretory, antiproliferative, and proapoptotic activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SOM230. CAS No. 396091-73-9. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-16381. | |
| Pasireotide acetate | Pasireotide (SOM230) acetate, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide acetate can suppress GH, IGF-I and ACTH secretion, indicating potential efficacy in acromegaly and Cushing's disease. Pasireotide acetate also exhibits antisecretory, antiproliferative, and proapoptotic activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SOM230 acetate. CAS No. 396091-76-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16381A. | |
| Pasireotide L-aspartate salt | Pasireotide (SOM230) L-aspartate salt, a long-acting cyclohexapeptide somatostatin analogue, can improve agonist activity at somatostatin receptors (subtypes sst1/2/3/4/5, pKi=8.2/9.0/9.1/<7.0/9.9, respectively). Pasireotide L-aspartate salt exhibits antisecretory, antiproliferative, and proapoptotic activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SOM230 L-aspartate. CAS No. 396091-77-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-79136. | |
| Pasotuxizumab | Pasotuxizumab (BAY 2010112) is a PSMA and CD3 bispecific T-cell engager (BiTE). Pasotuxizumab binds to CD3 and PSMA with KDs of 9.4 nM and 47.0 nM for human CD3 and PSMA. Pasotuxizumab can be used for research of metastatic castration-resistant prostate cancer (mCRPC)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 2010112; AMG 212; MT112. CAS No. 1442657-12-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99802. | |
| PAT1inh-B01 | PAT1inh-B01 is a selective SLC26A6 inhibitor. PAT1inh-B01 inhibits PAT1 (a Cl-/HCO3- exchanger)-mediated anion exchange (IC50: 350 nM). PAT1inh-B01 blocks fluid absorption in small intestine. PAT1inh-B01 can be used for research of small intestinal hyposecretory disorders[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1775330-54-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-154912. | |
| PAT-505 | PAT-505 is a potent, selective, noncompetitive and orally available autotaxin inhibitor, with an IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma. Uses: Scientific research. Category: Signaling pathways. CAS No. 1782070-22-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107781. | |
| Patchouli alcohol | Patchouli alcohol is a natural tricyclic sesquiterpene, exhibits anti-Helicobacter pylori, anti-inflammatory and antioxidant properties[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5986-55-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0207. | |
| Patecibart | Patecibart is a humanized immunoglobulin G4-kappa, anti-EDNRA monoclonal antibody. Patecibart is an endothelin receptor antagonist[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Getagozumab; GMA-301. CAS No. 2642374-04-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P990089. | |
| Pateclizumab | Pateclizumab (MLTA3698A) is a humanized antibody against lymphotoxin α (LTα), a transiently expressed cytokine on activated B and T cells (Th1, Th17), which are implicated in rheumatoid arthritis (RA) pathogenesis[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: MLTA3698A; RG7415; PRO283698. CAS No. 1202526-59-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990034. | |
| Patiromer | Patiromer is an orally active, selective and non-absorbable intestinal potassium (K+) polymer binder that reversibly binds potassium ions in exchange for calcium (Ca2+). Patiromer can rapidly and continuously reduce serum potassium levels, maintain a normal blood potassium state, and reduce serum aldosterone levels. Patiromer also increases fecal potassium excretion. Patiromer is mainly used in the study of hyperkalemia associated with diseases such as chronic kidney disease, diabetes, and heart failure, and is particularly suitable for improving renin-angiotensin-aldosterone system inhibitor (RAASi) therapy[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1208912-84-8. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-112961. | |
| Patisiran sodium | Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR amyloidosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1386913-72-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-132609. | |
| Patritumab | Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody to ERBB3. Patritumab shows a synergy with Cetuximab (HY-P9905), potently inhibits the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. Patritumab also induces cell apoptosis and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG-888; U3-1287. CAS No. 1262787-83-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99275. | |
| Patritumab deruxtecan | Patritumab deruxtecan (HER3-DXd) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab (HY-P99275) attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HER3-DXd; U3-1402. CAS No. 2227102-46-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99813. | |
| Patulin | Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Terinin. CAS No. 149-29-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N6779. | |
| PAV-104 | PAV-104 inhibits SARS-CoV-2 replication, with the MOI of 0.01. PAV-104 can interact with SARS-CoV-2 nucleocapsid (N) and interfered with its oligomerization, blocking particle assembly[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2923674-83-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158405. | |
| Pavurutamab | Pavurutamab (AMG-701) is a bispecific T cell engager molecule that anti-CD3 and anti-B cell maturation antigens (BCMA). Pavurutamab has an extended half-life based on Pacanalotamab (HY-P99798). The Fc of Pavurutamab is coupled to molecules to improve pharmacokinetic parameters. Pavurutamab has potential applications in immune regulation and multiple myeloma (MM)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG-701. CAS No. 2250292-39-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99814. | |
| Paxalisib | Paxalisib (GDC-0084) is a brain penetrant inhibitor of PI3K and mTOR, with Kis of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GDC-0084. CAS No. 1382979-44-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19962. | |
| Paxilline | Paxilline is an indole alkaloid mycotoxin derived from Penicillium paxilli, which effectively inhibits the BK channel through a channel-blocking mechanism. Paxilline also inhibits sarco/endoplasmic reticulum Ca2+-stimulated ATPase (SERCA), with IC50 values ranging from 5 μM to 50 μM for different SERCA isoforms. Paxilline exhibits significant anticonvulsant and neuroprotective effects, as well as certain antioxidant activity[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 57186-25-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N6778. | |
| Pazopanib | Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GW786034. CAS No. 444731-52-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10208. | |
| Pazopanib Hydrochloride | Pazopanib Hydrochloride (GW786034 Hydrochloride) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with an IC50 of 10, 30, 47, 84, 74, 140 and 146 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GW786034 Hydrochloride. CAS No. 635702-64-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12009. | |
| PB038 | PB038 is a Drug-liker containing a PEG unit and a cleavable linker attached to Exatecan[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2851058-71-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153180. | |
| PB089 | PB089 is a Drug-liker containing a PEG unit and a cleavable linker attached to Exatecan[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2892336-54-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-153947. | |
| PB131 | PB131 is a selective and brain-permeable HDAC6 inhibitor with high binding affinity (IC50: 1.8 nM). PB131 has potent anti-inflammatory activity. PB131 can be used for research of inflammation, especially neuroinflammation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2924425-63-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-149966. | |
| PB28 dihydrochloride | PB28 dihydrochloride, a cyclohexylpiperazine derivative, is a high affinity and selective sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM. PB28 dihydrochloride is also a σ1 antagonist with a Ki of 0.38 nM. PB28 dihydrochloride is less affinity for other receptors. PB28 dihydrochloride inhibits electrically evoked twitch in guinea pig bladder and ileum with EC50 values of 2.62 μM and 3.96 μM, respectively. PB28 dihydrochloride can modulate SARS-CoV-2-human protein-protein interaction. PB28 dihydrochloride induces caspase-independent apoptosis and has antitumor activity[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 172907-03-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108511. | |
| PB94 | PB94 is a selective HDAC11 inhibitor (IC50=108 nM). PB94 can be radiolabeled as [11C]-PB94 for use in positron emission tomography (PET), as well as brain uptake and metabolic properties in administered live animals. PB94 improves neuropathic pain in mice and could be used to study neurological indications[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3032970-74-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149766. | |
| PBA-1105 | PBA-1105 is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105 selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. PBA-1105 increases the autophagic flux of Ub-conjugated aggregates[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2410081-56-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161743. | |
| PBA-1105b | PBA-1105b is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105b increases the autophagic flux of Ub-conjugated aggregates. PBA-1105b is a drastically longer PEG-based linker than PBA-1105[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2941386-60-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161745. | |
| PBB3 | PBB3 is a tracer of tau PET. PBB3 can be used to detect levels of tau protein in Alzheimer's disease and non-Alzheimer's disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1565796-97-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114616. | |
| PBD dimer-2 | PBD dimer-2 (compound 2c) is a C8-linked pyrrolobenzodiazepine dimer. PBD dimer-2 can span an extra base pair and cross-link the 5-Pu-GA(T/A)TC-Py sequence. PBD dimer-2 can be used as a payload for antibody-agent conjugates (ADCs), and it can be used for the research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 145325-57-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148424. | |
| PBF-999 | PBF-999is a phosphodiesterase10A (PDE-10A) and adenosine A2A receptor (A2AR) dual antagonist. Uses: Scientific research. Category: Signaling pathways. CAS No. 1620909-95-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148954. | |
| PBIT | PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (JARID1) enzymes. PBIT inhibits JARID1B (KDM5B or PLU1) histone demethylase with an IC50 of about 3 μM. PBIT also inhibits JARID1A and JARID1C with IC50s of 6 μM and 4.9 μM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2514-30-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101451. | |
| PBK-IN-9 | PBK-IN-9 (compound 1160) is a potent PDZ binding kinase (PBK) inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1338540-55-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-120346. | |
| PBP10 | PBP10 is a decapeptide. PBP10 selectively binds to lipoteichoic acid (LTA), lipopolysaccharide (LPS) and phosphatidylinositol-4,5-bisphosphate (PIP2). PBP10 penetrates cell membranes and possesses bactericidal, anti-inflammatory, cell motility-inhibiting and actin assembly-regulating activities. PBP10 is applicable to relevant research on bacterial infections, microbe-induced inflammation, skin and soft tissue infections, as well as sepsis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 794466-43-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1116. | |
| PBRM1-BD2-IN-5 | PBRM1-BD2-IN-5 is a potent PBRM1 Bromodomain inhibitor with Kd values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5, respectively, and an IC50 value of 0.26 μM for PBRM1-BD2. PBRM1-BD2-IN-5 reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptide. PBRM1-BD2-IN-5 can be used to research anticancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2819989-61-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151532. | |
| (-)-p-Bromotetramisole oxalate | (-)-p-Bromotetramisole oxalate (L-p-Bromotetramisole oxalate) is an alkaline phosphatase inhibitor. (-)-p-Bromotetramisole (oxalate) is applicable to research related to erythroleukemia[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L-p-Bromotetramisole oxalate; 6-Bromolevamisole oxalate. CAS No. 62284-79-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19695. | |
| PBT 1033 | PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PBT 2. CAS No. 747408-78-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-105321. | |
| PBX-7016 | PBX-7016 is a Camptothecin (HY-16560) derivative. PBX-7016 can selectively inhibit Topoisomerase 1. PBX-7016 can specifically bind and degrade the cancer protein DDX5, thereby down-regulating the expression of anti-apoptotic proteins such as Survivin, Mcl-1, and XIAP, and promoting the apoptosis of cancer cells. PBX-7016 can be used to synthesis of ADCs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3003834-34-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-178226. | |
| PC190723 | PC190723 is a bacterial cell division protein FtsZ inhibitor (IC50 = 55 nM). PC 190723 prevents cell division. PC190723 has potent and selective bactericidal activity against staphylococci, including methicillin- and multi-drug-resistant Staphylococcus aureus. PC190723 induces nucleated assembly of Bs-FtsZ into single-stranded coiled protofilaments and polymorphic condensates. PC190723 can be studied in anti-bacterial infection research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 951120-33-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-146331. | |
| PC5-VC-PAB-MMAE | PC5-VC-PAB-MMAE consists the ADCs linker (PC5-VC-PAB) and potent tubulin inhibitor (MMAE). PC5-VC-PAB-MMAE is a agent-linker conjugate for ADC[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2922216-98-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-157544. | |
| PC786 | PC786 is an inhaled respiratory syncytial virus (RSV) L protein polymerase inhibitor. PC786 demonstrates potent antiviral activity against RSV-A (IC50 <0.09 to 0.71 nM) and RSV-B (IC50, 1.3 to 50.6 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1902114-15-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102038. | |
| PC Alkyne-PEG4-NHS ester | PC Alkyne-PEG4-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. PC Alkyne-PEG4-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1802907-98-7. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-140139. | |
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