MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| P 22077 | P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor with an EC50 of 8.01 μM. P 22077 also inhibits USP47 with an EC50 of 8.74 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1247819-59-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13865. |  |
| p38α inhibitor 2 | p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1095003-80-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131335. | |
| p38 MAP Kinase Inhibitor III | p38 MAP Kinase Inhibitor III (compound 7h) is a p38 MAPK inhibitor with an 50 of 0.9 μM. p38 MAP Kinase Inhibitor III also inhibits IL-1β and TNF-α release with 50 values of 0.37 μM and 0.044 μM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 581098-48-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-112389. | |
| p53 Activator 7 | p53 Activator 7 is a p53 mutation Y220C (MDM-2/p53) activator with an EC50 of 104 nM. p53 Activator 7 can bind to p53 mutant and restore its ability to bind DNA (WO2022213975A1; Example B-1)[1]. p53 Activator 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2849340-59-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-148416. | |
| p53 and MDM2 proteins-interaction-inhibitor (chiral) | p53 and MDM2 proteins-interaction-inhibitor (chiral) (Compound 32) is an inhibitor of the interaction between p53 and MDM2 proteins. Uses: Scientific research. Category: Signaling pathways. CAS No. 939981-37-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-70027. | |
| P53R3 | P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants, including p53R175H, p53R248W and p53R273H. P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1. P53R3 enhances the recruitment of wild-type p53 and p53M237I to several target gene promoters. P53R3 strongly enhances the mRNA, total protein and cell surface expression of the death receptor death receptor 5 (DR5). P53R3 is used for cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 922150-12-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122578. | |
| P5(PEG24)-VC-PAB-Exatecan | P5 (PEG24)-VC-PAB-Exatecan is a TOP1 inhibitor payload with antibody-conjugation-dependent activity. Conjugation of P5 (PEG24)-VC-PAB-Exatecan with Trastuzumab (HY-P9907) generates a DAR8 antibody-drug conjugate (ADCs) with antibody-like pharmacokinetic properties. P5 (PEG24)-VC-PAB-Exatecan induces S-phase and G2-M-phase cell cycle arrest, DNA damage and apoptosis in target-positive tumor cells, and releases damage-associated molecular patterns (DAMP) related to immunogenic cell death (ICD). The ADCs prepared from it exert bystander killing effects on non-target tumor cells. ADCs based on P5 (PEG24)-VC-PAB-Exatecan exhibit linker stability in vitro and in vivo, show in vivo efficacy, and can be used in research related to HER2-positive cancers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2928571-43-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-163099. | |
| P62-mediated mitophagy inducer | P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1809031-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115576. | |
| P62-RNF168 agonist-1 | P62-RNF168 agonist-1 (compound 5a) is a low cytotoxicity P62-RNF168 agonist that enhances the interaction between P62 and RNF168. P62-RNF168 agonist-1 induces a reduction in H2A ubiquitination mediated by RNF168 and impairs homologous recombination-mediated DNA repair. P62-RNF168 agonist-1 also inhibits the growth of xenograft tumors in mice in a dose-dependent manner[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2765180-17-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151799. | |
| P7C3-A20 | P7C3-A20 is a derivative of P7C3 with potent proneurogenic and neuroprotective activity. P7C3-A20 exerts an antidepressant-like effect. P7C3-A20 can cross the blood-brain barrier and therefore has the potential for brain injury treatment[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1235481-90-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15978. | |
| PA22-2 | PA22-2 (IKVAV sequence; Laminin A-chain fragment) is a biological active peptide. (This peptide is derived from mouse laminin a1. Cell matrix substrate constituted with this peptide can promote neurite outgrowth.). Uses: Scientific research. Category: Peptides. Alternative Names: IKVAV sequence; Laminin A-chain fragment. CAS No. 131435-36-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5353. | |
| PA452 | PA452, retinoic X receptor (RXR) specific antagonist, inhibits the effect of Retinoic acid (RA) on Th1/Th2 development[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 457657-34-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-108522. | |
| PA-8 | PA-8 is a potent, selective and orally active PACAP type I (PAC1) receptor antagonist. PA-8 inhibits the phosphorylation of CREB induced by PACAP in PAC1-, but not VPAC1- or VPAC2-receptor. PA-8 also inhibits PACAP-induced cAMP elevation with an IC50 of 2 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 878437-15-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133529. | |
| PA-915 | PA-915 (PAC1R antagonist 1) is a potent and orally active antagonist of PAC1 receptor. PA-915 inhibits pituitary adenylate cyclase-activating polypeptide (PACAP)-induced CREB phosphorylation. PA-915 can inhibit PACAP- and nerve injury-induced allodynia. PA-915 can be used for the research of neuropathic pain[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PAC1R antagonist 1. CAS No. 2305204-24-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147557. | |
| PAβN dihydrochloride | PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MC-207,110 dihydrochloride; Phe-Arg-β-naphthylamide dihydrochloride. CAS No. 100929-99-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-101444A. | |
| Pabinafusp alfa | Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JR-141. CAS No. 2140211-48-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99797. | |
| PAC-1 | PAC-1 is a procaspase-3 activator that induces apoptosis in cancer cells with an EC50 of 2.08 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Procaspase activating compound 1. CAS No. 315183-21-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-13523. | |
| Pacanalotamab | Pacanalotamab (AMG 420; BI-836909) is a bispecific T-cell engager (BiTE) targeting to BCMA and CD3E. BCMA refers to B cell maturation antigen, as Pacanalotamab redirecting T cells to BCMA expressing cells on the cell surface. Pacanalotamab conducts T-cell redirected lysis of human multiple myeloma (MM) cell lines[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG 420; BI-836909. CAS No. 2251756-52-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99798. | |
| PACAP (1-27), human, ovine, rat | PACAP (1-27), human, ovine, rat (PACAP 1-27) is the N-terminal fragment of PACAP-38, and is a potent PACAP receptor agonist with IC50s of 3 nM, 2 nM and 5 nM for rat PAC1, rat VPAC1 and human VPAC2, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PACAP 1-27. CAS No. 127317-03-7. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-P0176. | |
| PACAP (1-38) free acid | PACAP (1-38) free acid is a desamido-PACAP (1-38), human, ovine, rat (HY-P0221). PACAP (1-38) free acid can activate the human PAC1 receptor. PACAP (1-38) free acid induces cyclic AMP (cAMP) generation in both NS-1 neuroendocrine cells and non-neuroendocrine HEK293 cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 129405-61-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0221C. | |
| PACAP (1-38), human, ovine, rat | PACAP (1-38), human, ovine, rat is a PAC1 receptor agonist. PACAP (1-38), human, ovine, rat binds to PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2 with IC50s of 4 nM, 2 nM, and 1 nM, respectively. PACAP (1-38), human, ovine, rat increases the α-secretase activity. PACAP (1-38), human, ovine, rat elevates cytosolic Ca2+, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP (1-38), human, ovine, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP (1-38), human, ovine, rat can be used for neurotrophic and neuroprotective research[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pituitary Adenylate Cyclase Activating Polypeptide 38. CAS No. 137061-48-4. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P0221. | |
| PACAP (6-27) (human, ovine, rat) | PACAP (6-27) (human, ovine, rat) is a PACAP receptor antagonist that blocks the canine adrenal catecholamine response to exogenous vasoactive intestinal peptide (VIP). PACAP (6-27) (human, ovine, rat) has the potential to study cardiovascular and neurological diseases[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pituitary adenylate cyclase-activating peptide (6-27). CAS No. 136134-68-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P3117. | |
| PACAP (6-38), human, ovine, rat | PACAP (6-38), human, ovine, rat is a potent PACAP receptor antagonist with IC50s of 30, 600, and 40 nM for PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 143748-18-9. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-P0220. | |
| Pachymic acid | Pachymic acid is a lanostrane-type triterpenoid from P. cocos. Pachymic acid inhibits Akt and ERK signaling pathways. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3-O-Acetyltumulosic acid. CAS No. 29070-92-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-N0371. | |
| Pacibekitug | Pacibekitug (PF-04236921; TOUR-006) is a fully humanized IgG2 monoclonal antibody targeting IL-6. Pacibekitug binds to and neutralizes IL-6 signaling, thereby inhibiting the pathophysiological role of this pro-inflammatory cytokine in autoimmune diseases (such as rheumatoid arthritis, Crohn's disease, and systemic lupus erythematosus)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-04236921; TOUR-006. CAS No. 2948444-06-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P990937. | |
| Paclitaxel | Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 33069-62-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B0015. | |
| Paclitaxel-d5 | Paclitaxel-d5 is a deuterium-labeled Paclitaxel. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1129540-33-5. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-B0015S. | |
| Paclitaxel-DBCO | Paclitaxel-DBCO is Paclitaxel (HY-B0015) modified with a DBCO linker. Uses: Scientific research. Category: Signaling pathways. CAS No. 2414212-43-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-177999. | |
| Paclitaxel (Standard) | Paclitaxel (Standard) is the analytical standard of Paclitaxel. This product is intended for research and analytical applications. Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 33069-62-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0015R. | |
| PACMA 31 | PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues[1]. PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1401089-31-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100433. | |
| Pacritinib | Pacritinib (SB1518) is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). Pacritinib also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). Uses: Scientific research. Category: Signaling pathways. Alternative Names: SB1518. CAS No. 937272-79-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16379. | |
| Pacritinib citrate | Pacritinib (SB1518) citrate is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). Pacritinib citrate also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM). Pacritinib citrate can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SB1518 citrate. CAS No. 1228923-42-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16379B. | |
| Pactimibe sulfate | Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe sulfate (CS-505) inhibits ACAT with IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively[1]. Pactimibe sulfate (CS-505) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 μM. Moreover, Pactimibe sulfate (CS-505) obviously inhibits cholesteryl ester formation with an IC50 of 6.7 μM. Pactimibe sulfate (CS-505) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CS-505. CAS No. 608510-47-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100401A. | |
| Padnarsertib | Padnarsertib (KPT-9274) is an orally bioavailable, dual PAK4/Nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with IC50s of <100 nM and 120 nM, respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KPT-9274. CAS No. 1643913-93-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12793. | |
| PADRE peptide | PADRE peptide is a pan-HLA-DR binding epitope and immunostimulant. PADRE peptide binds to the peptide-binding groove of MHC class II molecules for presentation to CD4+ T cells, thereby effectively stimulating specific immune responses. PADRE peptide not only enhances anti-tumor immune responses, inhibits tumor growth and prolongs survival; it also significantly increases the frequency of E7-specific CD8+ T cells and improves therapeutic efficacy against TC-1 tumors when used in combination with E7 peptide-based vaccines and poly (I:C). The intensity of the immune response induced by PADRE peptide is lower than that of the Ii-PADRE DNA vaccine, and it fails to enhance the immune effect of CRT-E7 DNA. PADRE peptide is widely applicable to research on related tumors such as melanoma, glioblastoma and cervical cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 161147-59-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P11303. | |
| Padsevonil | Padsevonil (UCB0942) is a potent antiepileptic agent that selectively acts on presynaptic and postsynaptic targets. Padsevonil binds to synaptic vesicular protein 2 (SV2) with high affinity. Padsevonil is also a positive allosteric modulator and partial agonist of GABAAR, with high potency against α1 and α5 receptors. Padsevonil has antiepileptic effects in a variety of rodent models[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UCB-0942. CAS No. 1294000-61-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109009. | |
| Paederosidic acid | Paederosidic acid is isolated from P.?scandens with anticancer and anti?inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 18842-98-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-N6998. | |
| Paeoniflorin | Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Peoniflorin. CAS No. 23180-57-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-N0293. | |
| Paeoniflorin (Standard) | Paeoniflorin (Standard) is the analytical standard of Paeoniflorin. This product is intended for research and analytical applications. Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Peoniflorin (Standard). CAS No. 23180-57-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0293R. | |
| PAF (C18) | C18-PAF, octadecane PAF, is the ligand of platelet-activating factor and PAF G protein-coupled receptor (PAFR). C18-PAF has renovasodilator properties and antihypertensive lipid properties. C18-PAF increases renal blood flow and causes dose-dependent systemic hypotension[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 74389-69-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-130345. | |
| Pafolacianine | Pafolacianine (OTL 38) is a fluorescent imaging agent made of near-infrared dye used in detecting tumor lesions during surgical procedures. Pafolacianine excites at 774 to 775?nm and emits at 794 to 796?nm[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OTL 38. CAS No. 1628423-76-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139579. | |
| Pagibaximab | Pagibaximab is a chimeric IgG1 antibody recognizing the surface component lipoteichoic acid of S. aureus and S. epidermidis. Pagibaximab can be used to prevent staphylococcal sepsis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BSYX-A 110; Anti-S. Epidermidis LTA Recombinant Antibody. CAS No. 595566-61-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99309. | |
| PA Janelia Fluor® 646, SE | PA Janelia Fluor® 646, SE (PA-JF646-NHS) is a photo-activatable fluorescent dye. PA Janelia Fluor® 646, SE is a far-red light-excited, 405nm-activated NHS ester-based dye (λex/em = 650/664 nm). PA Janelia Fluor® 646, SE can achieve extremely low background and single-molecule-level ultra-high-resolution imaging through photo-controlled switching, making it a powerful tool for live cell super-resolution microscopy technology. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PA-JF646-NHS. CAS No. 2093120-32-0. Pack Sizes: 100 μg. Product ID: HY-133535. | |
| PAK4-IN-2 | PAK4-IN-2 is a highly potent PAK4 inhibitor with IC50 value of 2.7 nM. PAK4-IN-2 can arrest MV4-11 cells at G0/G1 phase and induce cell apoptosis. PAK4-IN-2 can be used for researching cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2488706-33-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-143490. | |
| Palacaparib | AZD-9574 is a potent and brain penetrant PARP1 inhibitor and shows >8000-fold selectivity for PARP1 compared to PARP2/3/5a/6. AZD-9574 acts by selectively inhibiting and trapping PARP1 at the sites of SSBs. AZD-9574 is an anti-cancer agent and can be used for HRD+?breast cancer and advanced solid malignancies research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD-9574. CAS No. 2756333-39-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145804. | |
| Palazestrant | Palazestrant is an antiestrogen and antineoplastic agent. Palazestrant can completely inhibit the activity of 17b-estradiol (E2) with IC50 value of 6.4 nM, and inhibit the proliferation of MCF7 and CAMA-1 cells with IC50 value of 1.4-1.6 nM. Palazestrant can inhibit ER+/HER2+ cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OP-1250. CAS No. 2092925-89-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-148789. | |
| Palbociclib | Palbociclib (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma[1][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PD 0332991. CAS No. 571190-30-2. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g; 2 g. Product ID: HY-50767. | |
| Palbociclib hydrochloride | Palbociclib (PD 0332991) hydrochloride is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib hydrochloride has potent anti-proliferative activity and induces cell cycle arrest in cancer cells. Palbociclib hydrochloride can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma[1][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PD-0332991 hydrochloride. CAS No. 571189-11-2. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g; 2 g. Product ID: HY-50767C. | |
| Palbociclib isethionate | Palbociclib (PD 0332991) isethionate is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib isethionate has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma[1][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PD 0332991 isethionate. CAS No. 827022-33-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-A0065. | |
| Palbociclib monohydrochloride | Palbociclib (PD 0332991) monohydrochloride is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib monohydrochloride has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma[1][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PD 0332991 monohydrochloride. CAS No. 827022-32-2. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g. Product ID: HY-50767A. | |
| Palbociclib monohydrochloride (Standard) | Palbociclib (monohydrochloride) (Standard) is the analytical standard of Palbociclib (monohydrochloride). This product is intended for research and analytical applications. Palbociclib (PD 0332991) monohydrochloride is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib monohydrochloride has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma[1][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PD 0332991 monohydrochloride (Standard). CAS No. 827022-32-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50767AR. | |
| Palbociclib-propargyl | Palbociclib-propargyl is a ligand for target protein CDK6 for PROTAC, and binds to CRBN ligand via a PEG linker to make a PROTAC CP-10. CP-10 shows a DC50 of 2.1 nM for CDK6[1]. Palbociclib-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PROTAC CDK6 ligand 1. CAS No. 2366269-23-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130296. | |
| Palbociclib (Standard) | Palbociclib (Standard) is the analytical standard of Palbociclib. This product is intended for research and analytical applications. Palbociclib (PD 0332991) is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively. Palbociclib has potent anti-proliferative activity and induces cell cycle arrest in cancer cells, which can be used in the research of HR-positive and HER2-negative breast cancer and hepatocellular carcinoma[1][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PD 0332991 (Standard). CAS No. 571190-30-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50767R. | |
| Palifosfamide | Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide, with antitumor activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Isophosphoramide mustard; IPM; ZIO-201. CAS No. 31645-39-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-14798. | |
| Paliperidone | Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 9-Hydroxyrisperidone. CAS No. 144598-75-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-A0019. | |
| Paliperidone palmitate | Paliperidone palmitate is an orally effective competitive antagonist of dopamine D2 receptors and 5-hydroxytryptamine 2A (5-HT2A) receptors that can cross the blood-brain barrier. Paliperidone palmitate competitively inhibits the effects of dopamine and 5-hydroxytryptamine by binding to dopamine D2 receptors and 5-HT2A receptors, regulating the balance of the neurotransmitter system and thus exerting antipsychotic activity. Paliperidone palmitate is mainly used in the research field of schizophrenia[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 9-Hydroxyrisperidone palmitate. CAS No. 199739-10-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0019A. | |
| Palivizumab | Palivizumab (MEDI 493) is a humanized monoclonal antibody against respiratory syncytial virus (RSV). Palivizumab can bind to RSV F protein with a Kd value of 1.4 nM. Palivizumab can prevent respiratory syncytial virus infection in cotton mice[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MEDI 493. CAS No. 188039-54-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P9944. | |
| Palladium(?) acetylacetonate | Palladium(II) acetylacetonate is a metal-organic complex. Palladium(II) acetylacetonate upregulates the expression of GRP78, ATF-4, XBP-1, CHOP, and phosphorylated c-Jun. Palladium(II) acetylacetonate induces Apoptosis. Palladium(II) acetylacetonate has anticancer effects against non-small cell lung cancer, gastric cancer, leukemia, and cervical cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Palladium(?) 2,4-pentanedionate; Pd(acac)2. CAS No. 14024-61-4. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W020952. | |
| Palladium hydroxide on activated carbon(20%)(wetted with ca. 55% Water) | Palladium hydroxide on activated carbon(20%)(wetted with ca. 55% Water) is a biological molecule. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pearlman's Catalyst (contains Pd, PdO) (wetted with ca. 55% Water). CAS No. 12135-22-7. Pack Sizes: 1 g; 5 g; 10 g; 25 g. Product ID: HY-W048457. | |
| Palladium (II) acetate | Palladium (II) acetate is a catalyst that catalyzes aromatic substitution reactions[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3375-31-3. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W002072. | |
| Palmatine chloride | Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 μM and 157μM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 μM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 10605-02-4. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 500 mg; 1 g. Product ID: HY-N0110. | |
| Palmitic acid | Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 57-10-3. Pack Sizes: 500 mg; 5 g; 10 g. Product ID: HY-N0830. | |
| Palmitic acid-13C | Palmitic acid-13C is the 13C-labeled Palmitic acid (HY-N0830). Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 287100-87-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0830S9. | |
| Palmitic acid-13C16 | Palmitic acid-13C16 is the 13C-labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 56599-85-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0830S6. | |
| Palmitic acid-13C16 sodium | Palmitic acid-13C16 sodium is the 13C-labeled Palmitic acid sodium. Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2483736-17-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N0830BS1. | |
| Palmitic acid-d2 | Palmitic acid-d2 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 62689-96-7. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-N0830S4. | |
| Palmitic acid-d3 | Palmitic acid-d3 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 75736-53-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg. Product ID: HY-N0830S5. | |
| Palmitic acid-d31 | Palmitic acid-d31 is the deuterium labeled Palmitic acid. Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 39756-30-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-N0830S2. | |
| Palmitic acid N-hydroxysuccinimide | Palmitic acid N-hydroxysuccinimide is used to conjugate proteins to prepare targeted delivery vectors. Palmitic acid N-hydroxysuccinimide can be used as lipophilic electrophile. Palmitic acid N-hydroxysuccinimide can be used for the covalent connection between palmitic acid and ovalbumin. Palmitic acid N-hydroxysuccinimide can be used to synthesize cetacyl derivatives of amino acids, aminoacyl-trNA, coenzyme A, mercaptoacetic acid and other amino and thiogenic compounds[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 14464-31-4. Pack Sizes: 1 mg; 1 g; 5 g. Product ID: HY-W011134. | |
| Palmitic acid sodium | Palmitic acid sodium is a long-chain saturated fatty acid commonly found in both animals and plants. Palmitic acid sodium can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid sodium is used to establish a cell steatosis model [1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 408-35-5. Pack Sizes: 5 g; 10 g. Product ID: HY-N0830B. | |
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