MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| ONT-993 | ONT-993 is an aliphatic hydroxylated metabolite. ONT-993 inhibits CYP2D6 (IC50=7.9 μM) and causes metabolism-dependent inactivation of CYP3A (KI=1.6 μM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AR 00440993. CAS No. 937263-81-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-151239. |  |
| Ontamalimab | Ontamalimab (SHP647) is a fully-human IgG2 monoclonal antibody targeting mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Ontamalimab can be used for the research of Crohn's disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SHP647. CAS No. 2098790-40-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99411. | |
| Ontorpacept | Ontorpacept (TTI-621) is a soluble fusion protein that consists of the human SIRPα N-terminal (1-118) linked to the Fc region of human IgG1. The N-terminal (1-118)-fragment of ontorpacept is a binding domain for CD47 which is an inhibitor of phagocytosis by macrophages. Ontorpacept is a CD47-blocking checkpoint inhibitor with antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TTI-621. CAS No. 2131089-46-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99777. | |
| Ontunisertib | Ontunisertib (AGMB-129) is an orally active and selective gastrointestinal-restricted ALK5 (TGFβR1) inhibitor. Ontunisertib blocks signalling of the pro-fibrotic TGFβ pathway. Ontunisertib can be used for the research of fibrostenotic Crohns disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AGMB-129. CAS No. 2647949-48-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-168990. | |
| Ontuxizumab | Ontuxizumab (MORAb-004) is a humanized IgG1/κ anti-endosialin (TEM-1 or CD248) monoclonal antibody with antitumor effects. Ontuxizumab can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MORAb-004. CAS No. 946415-62-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P99778. | |
| Onvansertib | NMS-1286937 is a potent, selective and orally available PLK1 inhibitor, with an IC50 of 2 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NMS-1286937; NMS-P937. CAS No. 1034616-18-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15828. | |
| Onvatilimab | Onvatilimab (JNJ-61610588) is a human IgG1κ anti-VISTA (V-domain Ig Suppressor of T-cell Activation) monoclonal antibody. Onvatilimab can be used in colorectal cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ-61610588; CI-8993; VSTB112. CAS No. 1969313-51-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99040. | |
| ONX-0914 | ONX-0914 (PR-957) is a selective inhibitor of low-molecular mass polypeptide-7 (LMP7), the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 is a noncompetitive irreversible inhibitor of the mycobacterial proteasome (Ki=5.2 μM). ONX-0914 reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PR-957. CAS No. 960374-59-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13207. | |
| Opabactin | Opabactin is an agonist for abscisic acid (ABA) receptor, which regulates the water use of plants by mimicking the effects of ABA with an IC50 of 7 nM. Opabactin inhibits the seed germination of Arabidopsis with an IC50 of 62 nM. Opabactin induces anti-transpiration response in plant tissue, and improves crop drought tolerance[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2407423-32-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162467. | |
| Opaganib | Opaganib (ABC294640) is a selective, competitive sphingosine kinase 2 (SK2) inhibitor with Ki of 9.8 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABC294640. CAS No. 915385-81-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16015. | |
| Opakalim | Opakalim (BHV-7000) is a selective Kv7.2/7.3 potassium channels activator with an EC50 of 0.6 μM. Opakalim shows minimal GABAA receptor activation and exhibits potent anti-seizure efficacy in the maximal electroshock seizure (MES) model. Opakalim can be used for the study of seizures[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BHV-7000. CAS No. 2376397-93-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172431. | |
| OPB-171775 | OPB-171775 is an orally active molecular glue. OPB-171775 forms ternary complex with phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12). OPB-171775 causes SLFN12 RNase-mediated cell death, activates SLFN12 RNase-associated GCN2 signaling pathway. OPB-171775 exhibits significant efficacy against gastrointestinal stromal tumor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2131210-15-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-162730. | |
| OPC-163493 | OPC-163493 is an orally active and liver-targeted mitochondrial uncoupling agent. OPC-163493 reduces the production of mitochondrial Δψ and ROS. OPC-163493 has anti-diabetic and lipid-lowering effects. In addition, OPC-163493 has a protective effect on cardiovascular disease[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1644467-84-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134769. | |
| OPC 4392 hydrochloride | OPC 4392 hydrochloride is an agonist for presynaptic dopamine receptor and an antagonist for postsynaptic D2 receptor. OPC 4392 reverses the Reserpine (HY-N0480)-induced dopamine accumulation, inhibits Apomorphine (HY-12723)-induced stereotypic and climbing behaviors in mouse models[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1329509-60-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-106781A. | |
| OPC-51803 | OPC-51803 is an orally active nonpeptide vasopressin V2 receptor agonist. OPC-51803 can be used for the research of micturition disorders that result in frequent micturition, such as that from polyuria, nocturnal polyuria, and some kinds of urinary incontinence[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 192514-54-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-116567. | |
| o,p'-DDE | o,p'-DDE (2,4-Dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDT. It accumulates in smallmouth buffalo, channel catfish, and largemouth bass, and in sediments from DDT manufacturing plants around the Huntsville Spring Branch-Indian Creek tributary system, where it is considered a persistent organic pollutant (POP). o,p'-DDE inhibits estrogen binding to the rainbow trout estrogen receptor (rtER) with an IC50 value of 3.2 μM. It induces concentration-dependent estradiol secretion in co-cultures of granulosa and theca cells isolated from porcine follicles. In ovo exposure to o,p'-DDE increases follicular degeneration and reduces testis size in Japanese medaka (O. latipes). Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2,4'-DDE; 2,4-Dichlorodiphenyldichloroethylene; 2,4'-DDE; o,p'-Dichlorodiphenyldichloroethylene. CAS No. 3424-82-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-121779. | |
| Opelconazole | Opelconazole (PC945), a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. Opelconazole is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC50s of 0.23 μM and 0.22 μM, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PC945. CAS No. 1931946-73-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-117766. | |
| Opemalirsen sodium | Opemalirsen sodium is an antisense oligonucleotide targeted to apolipoprotein L1 (APOL1). It is used for the study of Kidney disorders. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD2373 sodium, ION-972190 sodium. CAS No. 2639854-33-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-177653A. | |
| Opevesostat | Opevesostat (MK-5684; ODM-208) is an orally active and selective CYP11A1 inhibitor. Opevesostat has the potential for the research of metastatic castration-resistant prostate cancer (mCRPC)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-5684; ODM-208. CAS No. 2231294-96-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156628. | |
| o-Phenanthroline | o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1,10-Phenanthroline. CAS No. 66-71-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-W004544. | |
| o-Phenanthroline monohydrate | o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) monohydrate is also a MMP inhibitor[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1,10-Phenanthroline monohydrate. CAS No. 5144-89-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-Y1841. | |
| Ophioglonol | Ophioglonol is a lignan, which can be isolated from Ophioglossum petiolatum[1]. Uses: Scientific research. Category: Natural products. CAS No. 850894-19-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N11798. | |
| O-Phospho-L-serine | O-Phospho-L-serine is the immediate precursor to L-cystein in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L-Serine O-phosphate; L-SOP. CAS No. 407-41-0. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-15129. | |
| Ophthalmic acid | Ophthalmic acid is a ubiquitous metabolite and glutathione modulator, with a Ki of 0.95 mM for glyoxalase I. Ophthalmic acid competitively inhibits glyoxalase I, glutathione S-transferase, glutaredoxin, glutamate-cysteine ligase, protein disulfide reductase (glutathione), as well as non-selective cation channels. Ophthalmic acid is applicable in diabetes-related research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 495-27-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-126752. | |
| Opicapone | Opicapone (BIA 9-1067) is a potent third-generation catechol-O-methyltransferase (COMT) inhibitor for the research of Parkinson's disease and motor fluctuations. Opicapone decreases the ATP content of the cells with an IC50 of 98 μM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BIA 9-1067. CAS No. 923287-50-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14896. | |
| Opicinumab | Opicinumab (BIIB033) is a human IgG1 monoclonal antibody targeting LINGO-1. Opicinumab binds LINGO-1 to block its negative regulatory signaling, suppress axonal degeneration, enhance axonal regeneration, promote remyelination, and exert neuroprotective effects. Opicinumab maintains axonal protective effects during co-administration with methylprednisolone. Opicinumab can be used for the research of multiple sclerosis, acute optic neuritis, and optic neuritis.[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BIIB033. CAS No. 1422268-07-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99780. | |
| Opiorphin | Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 864084-88-8. Pack Sizes: 10 mg; 25 mg; 50 mg. Product ID: HY-W345510. | |
| OPN-IN-1 | OPN-IN-1 is an osteopontin (OPN) expression inhibitor. OPN-IN-1 has potential anti-breast cancer cell metastasis activity and can be used in the study of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2257492-95-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146064. | |
| Opnurasib | Opnurasib (JDQ-443) (NVP-JDQ443) is an orally active, potent, selective, and covalent KRAS G12C inhibitor. Opnurasib shows antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JDQ-443; NVP-JDQ443. CAS No. 2653994-08-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-139612. | |
| O-Propargyl-Puromycin | O-Propargyl-Puromycin, an alkyne analog of puromycin, is a potent protein synthesis inhibitor. O-Propargyl-Puromycin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1416561-90-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-15680. | |
| Oprozomib | Oprozomib (PR-047) is an orally bioavailable and selective peptide epoxyketone proteasome inhibitor with IC50s of 36 and 82 nM for proteasome (β5) and immunoproteasome (LMP7), respectively. Oprozomib (ONX 0912) induces apoptosis in MM cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ONX 0912; PR-047. CAS No. 935888-69-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12113. | |
| Optovin | Optovin is a reversible photoactivated TRPA1 ligand that enables light-mediated neuronal excitation. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 348575-88-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12809. | |
| Opucolimab | Opucolimab (HLX20) is an engineered anti-PD-L1 humanised IgG1 antibody. Opucolimab, when conjugated with camptothecin toxoid, yields the PD-L1-targeting ADC, HLX43 (HY-177439). HLX43 can be used for non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), esophageal squamous cell carcinoma (ESCC), melanoma (MEL), ovarian cancer (Ovc) research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HLX20; HLX43 antibody. CAS No. 2251771-79-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99785. | |
| OR-1896 | OR-1896 is an active long-lived metabolite of Levosimendan. OR-1896 is a highly selective phosphodiesterase (PDE) III isoform inhibitor and a powerful vasodilator. OR-1896 can open ATP-sensitive K+ channels and has Ca2+-sensitizing effect. OR-1896 mitigates cardiomyocyte apoptosis, cardiac remodeling and myocardial inflammation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 220246-81-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135746. | |
| Orange G | Orange G is an azo dye commonly found in textile wastewater and is mainly used for textile dyeing. Orange G has a coloring function and can give textiles a specific color. The stability and potential hazards of Orange G in the environment are often used to study the removal effects of various wastewater treatment technologies on difficult-to-degrade organic pollutants, especially the degradation of azo dyes. Related research focuses on how to destroy the azo bond of Orange G through chemical, physical or biological methods to achieve harmless treatment to solve the problem of textile wastewater pollution[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Acid Orange GG. CAS No. 1936-15-8. Pack Sizes: 10 mM * 1 mL in DMSO; 10 g; 25 g; 50 g; 100 g. Product ID: HY-135712. | |
| Orantinib | Orantinib (SU6668; TSU-68) is a multi-targeted receptor tyrosine kinase inhibitor with Kis of 2.1 μM, 8 nM and 1.2 μM for Flt-1, PDGFRβ and FGFR1, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SU6668; TSU-68. CAS No. 252916-29-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10517. | |
| Orcein | Orcein is an irreversible stain that specifically targets elastic fibers and can interact hydrophobically with the protein components in elastic fibers. Orcein makes elastic fibers in tissues appear purple or purple-red. Orcein can be used for morphological studies of Drosophila polytene chromosomes and for qualitative and quantitative analysis of elastic fibers, collagen fibers and other components in atherosclerotic plaques[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1400-62-0. Pack Sizes: 500 mg; 1 g. Product ID: HY-122266. | |
| Orcinol | Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3,5-Dihydroxytoluene. CAS No. 504-15-4. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g; 500 g. Product ID: HY-D0168. | |
| Ordastobart | Ordastobart (INBRX-106; ES-102) is a hexavalent OX40 agonist antibody. Ordastobart enhances OX40 receptor clustering, signaling, and downstream activation, thereby increasing the proliferation and activation of CD4+ and CD8+ T cells in vitro and in vivo. Ordastobart exhibits anti-tumor effects and improves survival in mouse models of cancer. Ordastobart is indicated for research in cancers such as fibrosarcoma and colorectal cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INBRX-106; ES-102. CAS No. 2708115-83-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991336. | |
| Ordesekimab | Ordesekimab (AMG 714; PRV-015) is a fully human IgG1κ anti-IL-15 (Interleukin Related) monoclonal antibody. The binding of Ordesekimab to IL-15 inhibits the interaction of IL-15 with the IL-2Rβ and common γ chain of the IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab has the potential for study of nonresponsive celiac disease (NRCD)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG 714; PRV-015. CAS No. 879293-15-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99410. | |
| Oregon green 488 azide | Oregon green 488 azide (Difluorocarboxyfluorescein azide, 6-isomer) is a bright green fluorescent azide-activated probe that reacts with terminal alkynes via copper-catalyzed azide-alkyne cycloaddition (CuAAC). Oregon green 488 azide can label goat anti-mouse IgG and exhibits excellent luminescence efficiency. Oregon green 488 azide, as a streptavidin conjugate, is used for flow cytometry staining of macrophages[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Difluorocarboxyfluorescein azide, 6-isomer. CAS No. 2648246-11-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D2769. | |
| Oregovomab | Oregovomab (Alt-2 monoclonal antibody) is a murine mAb targeting CA125. Oregovomab induces cytotoxic immune response against CA125 expressing tumor cells[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Alt-2 monoclonal antibody; MAB-B43.13; Oregovamab. CAS No. 213327-37-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P99409. | |
| Orelabrutinib | Orelabrutinib (ICP-022) is a potent, orally active, and irreversible Bruton's tyrosine kinase (BTK) inhibitor with potential antineoplastic activity. Orelabrutinib prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ICP-022. CAS No. 1655504-04-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129390. | |
| Orellanine | Orellanine, a nephrotoxic alkaloid found in Cortinarius orellanus, is an orally active and selective non-competitive inhibitor of alkaline phosphatase. Orellanine chelates iron, generates reactive oxygen species (ROS), induces DNA scission, forms ortho-semiquinone radicals, downregulates antioxidant defenses, and inhibits mitochondrial function. Orellanine induces caspase 8/9-mediated apoptosis. Orellanine inhibits synthesis of proteins, RNA, DNA, and mitochondrial protein synthesis, with metabolic activation required for cell-free protein synthesis inhibition. Orellanine can be used for the research of metastatic clear cell renal cell carcinoma, acute renal failure, chronic renal insufficiency, and kidney damage[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 37338-80-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W661499. | |
| Orexin A (human, rat, mouse) | Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hypocretin-1 (human, rat, mouse). CAS No. 205640-90-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-106224. | |
| Orforglipron | Orforglipron (LY3502970) (Compound 67) is an orally active agonist for Glucagon-like peptide-1 receptor (GLP-1R), which exhibits potency in ameliorates the type 2 diabete[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY3502970; GLP-1 receptor agonist 1. CAS No. 2212020-52-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112185. | |
| Orforglipron hemicalcium hydrate | Orforglipron hemicalcium hydrate (LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate) is the calcium salt hydrate form of Orforglipron (HY-112185). Orforglipron is an orally active agonist for Glucagon-like peptide-1 receptor (GLP-1R), which exhibits potency in ameliorating the type 2 diabete[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY3502970 hemicalcium hydrate; GLP-1 receptor agonist 1 hemicalcium hydrate. CAS No. 3008544-96-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112185A. | |
| Org-26576 | Org-26576 is a AMPA receptor positive allosteric modulator. Uses: Scientific research. Category: Signaling pathways. CAS No. 100044-96-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101216. | |
| Org 274179-0 | Org 274179-0 is a potent and allosteric antagonist of thyroid-stimulating hormone (TSH) receptor, with an IC50 of nanomolar concentration. Org 274179-0 completely inhibits TSH (and TSI)-mediated TSH receptor activation with little effect on the potency of TSH. Org 274179-0 can be used for the research of Graves' disease (GD)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1421683-12-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-153213. | |
| Org 27569 | Org 27569 is a potent CB1 receptor allosteric modulator, which increases agonist binding, yet blocks agonist-induced CB1 signaling. Uses: Scientific research. Category: Signaling pathways. CAS No. 868273-06-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13288. | |
| Org 43553 | Org 43553 is an orally active and low molecular weight (LMW) luteinizing hormone receptor (LH-R) agonist. Org 43553 shows agonistic activity to human LH and FSH receptors with EC50 values of 3.7 and 110 nM, respectively. Org 43553 can be used for the research of endocrine[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 501444-88-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19464. | |
| ORIC-101 | ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC50 of 5.6 nM. Anti-cancer activity. ORIC-101 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2222344-98-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112710. | |
| Oridonin | Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC-250682; Isodonol. CAS No. 28957-04-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-N0004. | |
| Orientin | Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 28608-75-5. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg. Product ID: HY-N0405. | |
| Orilanolimab | Orilanolimab (SYNT001) is a humanized, de-immunized and FcRn-blocking monoclonal antibody. Orilanolimab blocks the interaction between FcRn and the Fc portion of IgG molecules. Orilanolimab impedes IgG IC activation of the FcRn-mediated adaptive immune function. And Orilanolimab disrupts the associated pathways related to IgG homeostasis and innate and adaptive immunity[1][2]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: SYNT001; ALXN1830. CAS No. 2066544-85-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99791. | |
| Orismilast | Orismilast (LEO-32731) is an orally active and selective PDE4 inhibitor used for the research of inflammatory diseases. Orismilast demonstrates potent inhibition of PDE4B and PDE4D subtype splice variants[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LEO-32731. CAS No. 1353546-86-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117960. | |
| Oritavancin diphosphate | Oritavancin diphosphate (LY333328 diphosphate), a semisynthetic derivative of Vancomycin (HY-B0671), is an orally active glycopeptide antibiotic with bactericidal activity against gram-positive organisms. Oritavancin diphosphate shows antibacterial effect against B. anthracis, such as Ames strain with a MIC value of 0.015 g/mL. Oritavancin diphosphate inhibits cell wall synthesis and disrupts the membrane potential. Oritavancin diphosphate inhibits ArlS kinase activity thereby interfering the signal transduction. Oritavancin diphosphate enters cells by adsorptive endocytosis, which drives it to lysosomes, where it exerts antibiotic activity[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY333328 diphosphate. CAS No. 192564-14-0. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B1831A. | |
| Orlistat | Orlistat (Tetrahydrolipstatin) is a well-known irreversible inhibitor of pancreatic and gastric lipases. Orlistat is also an inhibitor of fatty acid synthase (FASN), is used orally for long-term research of obesity[1]. Anti-atherosclerotic effect[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tetrahydrolipstatin; Ro-18-0647. CAS No. 96829-58-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-B0218. | |
| ORM-10103 | ORM-10103 is a specific inhibitor of the Na+/Ca2+ exchanger (NCX), which decreases the NCX current with estimated IC50s of 55 and 67 nM at -80 and at 20 mV, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 488847-28-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-128678. | |
| Orniplabin | Orniplabin (SMTP-7) is a low-molecular-weight compound that enhances plasminogen-fibrin binding, urokinase-catalyzed activation of plasminogen, and urokinase and plasminogen-mediated fibrin degradation. Orniplabin shows potential thrombolytic and anti-inflammatory effects. Orniplabin inhibits ROS[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SMTP-7. CAS No. 733805-92-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-122311. | |
| Orobol | Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC50=1.24-4.45 μM). Orobol also inhibits PI3K isoforms (IC50=3.46-5.27 μM for PI3K α/β/γ/K/δ)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 480-23-9. Pack Sizes: 1 mg; 2 mg; 5 mg. Product ID: HY-N3127. | |
| Orotic acid | Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6-Carboxyuracil; Vitamin B13. CAS No. 65-86-1. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-N0157. | |
| Orotic acid-13C,15N2 monohydrate | Orotic acid-13C,15N2 (monohydrate) is the 13C and 15N labeled Orotic acid[1]. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6-Carboxyuracil-13C,15N2 monohydrate; Vitamin B13-13C,15N2 monohydrate. CAS No. 1346602-15-0. Pack Sizes: 1 mg. Product ID: HY-N0157S1. | |
| Orotic acid (Standard) | Orotic acid (Standard) is the analytical standard of Orotic acid. This product is intended for research and analytical applications. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6-Carboxyuracil (Standard); Vitamin B13 (Standard). CAS No. 65-86-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0157R. | |
| Orotidine | Orotidine, a nucleotide, is an intermediate in pyrimidine nucleotide biosynthesis in RNA and DNA. Orotidine is mainly found in bacteria, fungi and plants[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 314-50-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-113226. | |
| Orotidine 5-monophosphate trisodium | Orotidine 5'-monophosphate trisodium is a pyrimidine nucleotide. Orotidine 5'-monophosphate trisodium is synthesized via the de novo synthesis pathway for DNA synthesis in a large number of microorganisms including M. tuberculosis, S. cerevisiae, S. typhimurium and P. falciparum to name a few. The synthesis of orotidine 5'-monophosphate trisodium uses phosphoribosyl pyrophosphate (PRPP) and orotic acid (OA) as the substrates catalyzed by orotate phosphoribosyltransferase (OPRT)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Orotidine monophosphate trisodium; Orotidylic acid trisodium. CAS No. 68244-58-6. Pack Sizes: 1 mg. Product ID: HY-N8060A. | |
| Oroxylin A | Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Baicalein 6-methyl ether; 6-Methoxybaicalein. CAS No. 480-11-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N0560. | |
| Oroxylin A-7-O-glucuronide | Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Oroxyloside; Oroxylin A-7-O-β-D-glucuronide. CAS No. 36948-76-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N2481. | |
| Orphenadrine | Orphenadrine ((±)-Orphenadrine) is a skeletal muscle relaxant and NMDA antagonist that also has antiparkinsonian, antihistamine, antitremor, antispasmodic, and analgesic effects. Orphenadrine inhibits the binding of [3H]MK-801 to the phencyclidine (PCP) binding site of the NMDA receptor. Orphenadrine is also an anticholinergic and CYP2B inducer. Orphenadrine may exert pro-tumor effects, causing CAR nuclear translocation, resulting in microsomal reactive oxygen species (ROS) production and oxidative stress. Orphenadrine also exerts neuronal protection, protecting rat cerebellar granule cells (CGC) from 3-NPA-induced death and has inhibitory potential against neurodegenerative diseases mediated by NMDA receptor overactivation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-Orphenadrine. CAS No. 83-98-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-157959. | |
| Orteronel | Orteronel (TAK-700) is a highly selective inhibitor of human 17,20-lyase (CYP17) with IC50 of 38 nM, and exhibits >1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAK-700. CAS No. 566939-85-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10505. | |
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