MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| OBI-992 drug-linker | OBI-992 drug-linker is a drug-linker conjugate composed of a TOP I inhibitor Exatecan (HY-13631) and a linker. OBI-992 drug-linker exhibits antitumor property in mouse models and can be used for synthesis of ADC OBI-992[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3039487-10-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-168489. |  |
| Obicetrapib | Obicetrapib (TA-8995; DEZ-001) is an orally active cholesteryl ester transfer protein (CETP) inhibitor. Obicetrapib potently reduces atherogenic lipoproteins (such as LDL-C, ApoB, Lp (a)) and increases HDL-C. Obicetrapib can be used for the research of dyslipidemia and atherosclerotic cardiovascular disease (ASCVD)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TA-8995; DEZ-001; AMG-899. CAS No. 866399-87-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18778. | |
| Obidoxime dichloride | Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces acute toxicity of sarin-evaluated[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 114-90-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W011108. | |
| Obiltoxaximab | Obiltoxaximab (ETI 204) is the second and potent anti-protective antigen (PA) monoclonal antibody with immunogenicity. Obiltoxaximab plays a central role in anthrax toxin assembly and target cell intoxication, promoting survival, and inhibiting bacterial spread to the periphery in animal models. Obiltoxaximab can be used in the research of inhalational anthrax, bacteremia and toxemia[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ETI 204. CAS No. 1351337-07-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9932. | |
| Obinutuzumab | Obinutuzumab (GA101) a Type II CD20 humanized IgG1 monoclonal antibody in development for non-Hodgkin lymphoma. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GA101; Anti-Human CD20 type II, Humanized Antibody. CAS No. 949142-50-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P9910. | |
| Obrindatamab | Obrindatamab is a humanized anti-B7-H3/CD3 bispecific antibody. Obrindatamab binds to B7-H3 and CD3, thereby mediating redirected cytotoxic T-lymphocyte (CTL) activity against B7-H3-expressing cancer cells. Obrindatamab can be used in research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MGD009. CAS No. 2069959-72-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99762. | |
| Obrixtamig | Obrixtamig (BI 764532; OBT 620) is an CD3E/DLL3-targeting L-κ-G1-h-CH2-CH3_L-λ-G1-h-CH2-CH3 type human antibody. Obrixtamig is a delta-like ligand 3 (DLL3)/CD3 IgG-like T-cell engager. Obrixtamig can be used for research of DLL3-positive small cell lung cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BI 764532; OBT 620. CAS No. 2851943-09-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P990932. | |
| Obtusin | Obtusin, isolated from Cassia obtusifolia Linn seed, is a highly selective and competitive human monoamine oxidase-A (hMAO-A) inhibitor with an IC50 of 11.12 μM and a Ki of 6.15 μM. Obtusin plays a preventive role in neurodegenerative diseases, especially anxiety and depression[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 70588-05-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-N6057. | |
| Obtustatin | Obtustatin is a non-RGD disintegrin consisting of 41 residues. Obtustatin inhibits the adhesion of α1β1 integrin to type IV Collagen (HY-NP003), blocks α1β1 integrin signaling in endothelial cells, and suppresses FGF2-induced angiogenesis. Obtustatin inhibits tumor progression in mouse models and upregulates VEGF expression in sarcoma-bearing mice. Obtustatin can be used in research related to Lewis lung carcinoma and S-180 sarcoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 404882-00-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1408. | |
| Ocadusertib | Ocadusertib is a potent Serine/Threonine kinase receptor-interacting protein kinase 1 (RIPK1) inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY3871801; R 552. CAS No. 2382811-41-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148297. | |
| Ocankitug | Ocankitug (CM-326) is a humanized IgG1κ antibody targeting thymic stromal lymphopoietin (TSLP). It can be used for research on type 2 inflammatory respiratory diseases, including moderate to severe asthma, chronic sinusitis with nasal polyps, etc. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CM-326. CAS No. 2803351-66-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990933. | |
| Ocaperidone | Ocaperidone is an effective antipsychotic agent, acting as a potent 5-HT2 and dopamine D2 antagonist, and a 5-HT1A agonist, with Kis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT2, a1-adrenergic receptor, dopamine D2, histamine H1 and a2-adrenergic receptor, respectively, and a pEC50 and pKi of 7.60 and 8.08 for h5-HT1A. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R79598. CAS No. 129029-23-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101094. | |
| Ochnaflavone | Ochnaflavone is an inhibitor of IIA-type secretory phospholipase A2 (sPLA2-IIA) with an IC50 of 3.45 μM. Ochnaflavone exhibits significant anti-inflammatory and liver-protective effects, capable of inhibiting the degradation of phosphatidylethanolamine (PE) and lipid peroxidation induced by carbon tetrachloride (CCl4) in rat liver, with an IC50 of 7.16 μM for lipid peroxidation. Ochnaflavone can be used in research on liver damage and inflammatory diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 50276-96-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N7327. | |
| Ochratoxin B | Ochratoxin B is an orally active secondary metabolite of Aspergillus ochraceus and non-chlorinated analog of the mycotoxin Ochratoxin A. Ochratoxin B reduces the toxic effects of Ochratoxin A (HY-N6788). Ochratoxin B inhibits cell division. Ochratoxin B causes craniofacial malformations in Xenopus laevis embryos[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4825-86-9. Pack Sizes: 1 mg. Product ID: HY-N6786. | |
| Ochromycinone | Ochromycinone ((Rac)-STA-21) is a natural antibiotic and a STAT3 inhibitor. Ochromycinone can inhibits STAT3 DNA binding activity, STAT3 dimerization. Ochromycinone has anticancer and antimicrobial activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (Rac)-STA-21. CAS No. 111540-00-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18061. | |
| (+)-Ochromycinone | (+)-Ochromycinone is a natural antibiotic that potently inhibits STAT3. (+)-Ochromycinone is used in the researches of cancers and psoriasis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: STA-21. CAS No. 28882-53-3. Pack Sizes: 1 mg. Product ID: HY-121482. | |
| Ocifisertib | CFI-400945 free base is a potent, selective and orally bioavailable PLK4 inhibitor with a Ki and an IC50 of 0.26 nM and 2.8 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CFI-400945 free base. CAS No. 1338806-73-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12300. | |
| Ocifisertib fumarate | CFI-400945 fumarate is a potent, selective and orally bioavailable PLK4 inhibitor with a Ki and an IC50 of 0.26 nM and 2.8 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CFI-400945 fumarate. CAS No. 1616420-30-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12300B. | |
| Ocinaplon | Ocinaplon (DOV 273547) is an orally active positive allosteric modulator of GABAA receptor, with an EC50 ranging from 3.07 μM (α1β2γ2 subtype) to 10.03 μM (α1β2γ3 subtype). Ocinaplon enhances GABA-stimulated chloride currents across multiple GABAA receptor subtypes, with varying potency between different subtypes. Ocinaplon exerts anxiolytic and anticonvulsant effects, and causes motor impairment at high doses. Ocinaplon can be used for research on generalized anxiety disorder[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DOV 273547. CAS No. 96604-21-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W001692. | |
| Oclacitinib | Oclacitinib is a novel JAK inhibitor. Oclacitinib is most potent at inhibiting JAK1 (IC50=10 nM). Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-03394197. CAS No. 1208319-26-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13577. | |
| Oclacitinib monomaleate | Oclacitinib maleate (PF-03394197 maleate) is a novel JAK inhibitor. Oclacitinib maleate (PF-03394197 maleate) is most potent at inhibiting JAK1 (IC50=10 nM). Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-03394197 monomaleate. CAS No. 1640292-55-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13577A. | |
| Ocrelizumab | Ocrelizumab (Ocrevus) is a humanized anti-CD20 monoclonal antibody. Ocrelizumab can induce B cell depletion and inhibit multiple sclerosis lesions in mice through antibody dependent cytotoxicity (ADCC)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2H7; PRO70769; RG1594. CAS No. 637334-45-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9960. | |
| o-Cresol sulfate | o-Cresol sulfate is a biomarker related to CAR T cell-independent and dependent metabolic and inflammatory. o-Cresol sulfate can be used to predict patient response[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3233-56-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156199. | |
| Octacosane-d58 | Octacosane-d58 is the deuterium labeled Octacosane[1]. Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l[2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: n-Octacosane-d58; NSC 5549-d58. CAS No. 16416-33-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W272217S. | |
| Octacosanoic acid | Octacosanoic acid is a very long-chain saturated fatty acid. It is the major component of D-003, a mixture of very long-chain aliphatic acids purified from sugar cane wax that has antiplatelet and cholesterol-lowering activities in animal models[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Montanic acid. CAS No. 506-48-9. Pack Sizes: 25 mg; 50 mg. Product ID: HY-N8425. | |
| Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate (Standard) | Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate (Standard) is the analytical standard of Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate. This product is intended for research and analytical applications. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Stearyl 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionate (Standard). CAS No. 2082-79-3. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-W099555R. | |
| Octadecyl Rhodamine B chloride | Octadecyl Rhodamine B chloride is an amphiphilic fluorescent probe with both membrane-binding ability and fluorescent properties, which easily forms aggregates in aqueous phase leading to self-quenching. Octadecyl Rhodamine B chloride can be used for cell membrane staining and further applied in membrane biology research. The maximum absorption/emission wavelengths of Octadecyl Rhodamine B chloride monomer in Triton X-100 are 565 nm/585 nm; the absorption peaks of aggregates in water are blue-shifted to 524 nm and 574 nm, with significantly quenched fluorescence[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 65603-19-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W127703. | |
| Octahydrocurcumin | Octahydrocurcumin (Hexahydrobisdemethoxycurcumin) is an orally active anticancer and anti-inflammatory agent, and is the final hydrogenated metabolite of Curcumin (HY-N0005) in vivo. Octahydrocurcumin exerts its anti-tumor and anti-inflammatory effects by inducing the mitochondrial apoptosis pathway and inhibiting the TAK1-NF-κB-COX-2 pathway, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Hexahydrobisdemethoxycurcumin. CAS No. 36062-07-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0894. | |
| Octanal-d16 | Octanal-d16 is the deuterium labeled Octanal. Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC50 value of 3.5 μg/mL[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1219794-66-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N8015S. | |
| Octanoic acid | Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes. Octanoic acid is also a tremor-suppressing agent[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Caprylic acid. CAS No. 124-07-2. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g; 25 g; 50 g; 100 g; 250 g; 500 g; 1000 g. Product ID: HY-41417. | |
| Octanoic acid-13C4 | Octanoic acid-13C4 is the 13C labeled Octanoic acid. Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Caprylic acid-13C4. CAS No. 159118-65-7. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-41417S4. | |
| Octanoyl-L-carnitine-d3 chloride | Octanoyl-L-carnitine-d3 (chloride) is the deuterium labeled Octanoyl-L-carnitine chloride[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1334532-24-9. Pack Sizes: 10 mM * 1 mL in Water; 5 mg. Product ID: HY-139392S. | |
| Octenidine dihydrochloride | Octenidine dihydrochloride is an effective antiseptic compound for skin mucous membranes and wounds. Uses: Scientific research. Category: Signaling pathways. CAS No. 70775-75-6. Pack Sizes: 10 mM * 1 mL in Water; 200 mg; 1 g; 5 g. Product ID: HY-B2170A. | |
| Octenyl succinic anhydride | Octenyl succinic anhydride is a versatile chemical intermediate. Octenyl succinic anhydride can undergo esterification with polysaccharides such as starch and Inulin (HY-N7075). Octenyl succinic anhydride affects the intermolecular interactions on the outer surfaces of two starch granules by altering the molecular surface structure. Octenyl succinic anhydride modifies the properties of polysaccharides. Octenyl succinic anhydride can be used for starch esterification to produce OS-starch, an amphiphilic hydrocolloid[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 26680-54-6. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g. Product ID: HY-145942. | |
| Octinoxate | Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Octyl methoxycinnamate. CAS No. 5466-77-3. Pack Sizes: 10 mM * 1 mL in Ethanol; 500 mg; 1 g. Product ID: HY-B1234. | |
| Octisalate-d4 | Octisalate-d4 (Octyl salicylate-d4; 2-Ethylhexyl salicylate-d4) is the deuterium labeled Octisalate (HY-B0929). Octisalate (Octyl salicylate) is an organic compound with high lipophilicity, which is used in sunscreens and cosmetics that absorbs UVB rays[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Octyl salicylate-d4; 2-Ethylhexyl salicylate-d4. CAS No. 2469274-09-5. Pack Sizes: 1 mg. Product ID: HY-W714767. | |
| Octocrylene | Octocrylene is an organic ultraviolet (UV) filter that absorbs mainly UVB radiation and shorter UVA wavelengths. Octocrylene acts as a partial agonist of PPARγ, which alters the gene transcription profile of lipid metabolism enzymes. In addition, Octocrylene is cytotoxic and genotoxic to human skin fibroblasts and mediates the biosynthesis of estrogens such as estriol in zebrafish larvae, while affecting antioxidant pathways including glutathione transferase and peroxisomes[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6197-30-4. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 5 g; 10 g. Product ID: HY-A0087. | |
| Octopamine-d4 hydrochloride | Octopamine-d4 (hydrochloride) is the deuterium labeled Octopamine hydrochloride. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-p-Octopamine-d4 hydrochloride. CAS No. 1219803-62-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0528AS. | |
| Octopamine hydrochloride | Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-p-Octopamine hydrochloride. CAS No. 770-05-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0528A. | |
| Octreotide | Octreotide (SMS 201-995) is a somatostatin receptor agonist and synthetic octapeptide endogenous somatostatin analogue. Octreotide (SMS 201-995) can bind to the somatostatin receptor and mainly subtypes 2, 3, and 5, increases Gi activity, and reduces intracellular cAMP production. Octreotide (SMS 201-995) has antitumor activity, mediates apoptosis and may also be used in disease studies in acromegaly[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SMS 201-995. CAS No. 83150-76-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0036. | |
| Octreotide acetate | Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SMS 201-995 acetate. CAS No. 79517-01-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17365. | |
| Octyl-α-hydroxyglutarate | Octyl-α-hydroxyglutarate (octyl-2-HG) increases histone methylation and enhances viability of LMP1-negative NPC cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Octyl-2-HG. CAS No. 2097068-39-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-103641C. | |
| Octyl-α-ketoglutarate | Octyl-α-ketoglutarate (1-Octyl 2-oxopentanedioate) is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional tricarboxylic acid (TCA) cycle, stimulating prolyl hydroxylase (PHD) activity. In addition, Octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1-Octyl 2-oxopentanedioate. CAS No. 876150-14-0. Pack Sizes: 1 mg (38.71 mM * 100 μL in Methyl acetate); 5 mg (38.71 mM * 500 μL in Methyl acetate). Product ID: HY-114333. | |
| Octylamine | Octylamine (n-Octylamine) is a chemical reagent featuring a primary amine and a saturated C8 tail. The primary amine is a versatile substrate which can be used to build a wide variety of bonds. Compounds such as this may be used as intermediates in building lipids for use in lipid nanoparticles. Uses: Scientific research. Category: Signaling pathways. Alternative Names: n-Octylamine. CAS No. 111-86-4. Pack Sizes: 10 mM * 1 mL in DMSO; 250 g; 500 g; 1 k g. Product ID: HY-W032014. | |
| Octyl glucose neopentyl glycol | Octyl glucose neopentyl glycol (OGNG) is a neopentyl glycol detergent that can be used to maintain the stability of membrane proteins[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OGNG. CAS No. 1257853-32-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-138192. | |
| Odanacatib | Odanacatib (MK-0822) is a potent and selective inhibitor of cathepsin K, with an IC50 of 0.2 nM for human cathepsin K. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-0822. CAS No. 603139-19-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-10042. | |
| Odatroltide | Odatroltide (LT3001; DHDMIQK(KAP)) is a P-selectin inhibitor. Odatroltide is a peptide molecule comprising a tripeptide Pro-Ala-Lys (PAK) and an (S)-6,7-dihydroxy-1,1-dimethyl-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid domain. Odatroltide can restore cerebral blood flow, scavenge free radicals, and inhibit leukocyte migration. Odatroltide possesses thrombolytic and anti-thrombotic activities[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LT3001; DHDMIQK(KAP). CAS No. 1639303-73-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-132828. | |
| O-Desmethylangolensin | O-Desmethylangolensin is a metabolite of soy isoflavone, daidzein metabolized by gut microbiota. O-Desmethylangolensin possesses antioxidant activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 21255-69-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N4075. | |
| O-Desmethyl Midostaurin | O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CGP62221; O-Desmethyl PKC412. CAS No. 740816-86-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-129491. | |
| Odevixibat | Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: A4250. CAS No. 501692-44-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109120. | |
| Oditrasertib | Oditrasertib (SAR443820) is an orally active, BBB-penetrable and selective reversible inhibitor of RIPK1. Oditrasertib can be used in the research of chronic inflammatory central nervous system diseases, such as amyotrophic lateral sclerosis and multiple sclerosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SAR443820; DNL788. CAS No. 2252271-93-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148787. | |
| O-DMT-2,2-di(ethoxycarbonyl)propan-1,3-diol | O-DMT-2,2-di(ethoxycarbonyl)propan-1,3-diol is a chemical phosphorylation reagent used for the synthesis of 5'-phosphorylated oligonucleotides. It contains the chemical protective group DMT in its structure, which allows for purification through C18 columns or reversed-phase chromatography[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 171285-25-9. Pack Sizes: 50 mg; 100 mg. Product ID: HY-W784557. | |
| ODN 1018 | ODN 1018 (1018 ISS) is a TLR9 agonist and immune modulator. ODN 1018 exhibits adjuvant activity and augments CD8+ T cell responses with LNP-encapsulated OVA peptides. ODN 1018 triggers sustained suppression of allergic airway inflammation. ODN 1018 can be used for the research of allergic asthma and systemic lupus erythematosus[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1018 ISS. CAS No. 937402-51-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-150724. | |
| ODN 1585 | ODN 1585 is a potent inducer of IFN and TNFα production. ODN 1585 is a potent stimulator of NK (natural killer) function. ODN 1585 increases CD8+ T-cell function, including the CD8+ T cell-mediated production of IFN-γ. ODN 1585 induces regression of established melanomas in mice. ODN 1585 can confer complete protection against malaria in mice. ODN 1585 can be used for acute myelogenous leukemia (AML) and malaria research. ODN 1585 can be used as a vaccine adjuvant[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 386832-46-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-150725. | |
| ODN 1668 | ODN 1668, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 has strong immune regulatory properties, can enhance the level of antibody IgG2 subtype, promote the immune response of T cells and B cells, and can be used in the study of vaccine adjuvants. In addition, CpG ODN 1668 induces an antimicrobial immune response via a CaTLR9 dependent pathway in groupers. Sequence: 5'-tccatgacgttcctgatgct-3[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1186063-66-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-150726. | |
| ODN 1826 | ODN 1826 is a class B CpG ODN (oligodeoxynucleotide) and TLR9 agonist. ODN 1826 induces NO and iNOS production and enhances Apoptosis. ODN 1826 enhances immune surveillance. ODN 1826 increases aortic atherosclerotic plaque size. ODN 1826 has antitumor activity against lung cancer, glioma and melanoma[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CpG 1826. CAS No. 202668-42-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-146245. | |
| ODN 2007 | ODN 2007, a class B CpG ODN (oligodeoxynucleotide), is a Toll-like receptor (TLR) ligand. ODN 2007 can be used as an immunomodulator, vaccine adjuvant, and enhance immune responses in mammals, fish, and humans. ODN 2007 sequence: 5'-TCGTCGTTGTCGTTTTGTCGTT-3'[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 455348-63-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-150734. | |
| ODN 20844 | ODN 20844, a guanine-modified inhibitory oligonucleotide (INH-ODN), is a TLR7 and TLR9 (Toll-like receptor) inhibitor, and its parent is INH-ODN 2088. ODN 20844 disrupts TLR7- and TLR9-mediated immune cell immune responses. ODN 20844 sequence: 5'-TCCTGGCGc7GGGAAGT-3'[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1964506-29-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-150736. | |
| ODN 2088 | ODN 2088 is a potent TLR3, TLR7 and TLR9 inhibitor. ODN 2088 shows no cytotoxic. ODN 2088 inhibits the release of IFN-α and IL-6[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1146541-45-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-150738. | |
| ODN 2216 | ODN 2216 is a type A CpG oligodeoxynucleotide vaccine adjuvant and a TLR9 agonist. ODN 2216 interacts with TLR9 in the lysosomes of CD4+ T cells and activates feedback-dependent signaling pathways. ODN 2216 induces the production of type I interferons, IL-6 and TGF-β via the IRAK4/IRF7 axis, while increasing intracellular ATP levels. ODN 2216 not only induces the differentiation of CD4+ T cells into anti-inflammatory Th3-like regulatory phenotypes to inhibit autologous proliferation, but also enhances the specific CD8+ T cell-mediated cytotoxicity against Mammaglobin-A in breast cancer cells. ODN 2216 is widely used in studies related to breast cancer and systemic lupus erythematosus[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 332437-00-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150741. | |
| ODN 2395 | ODN 2395 is a C class oligodeoxynucleotide and can be used as vaccine adjuvant. ODN 2395 is also a TLR9 agonist. ODN 2395 can be used in the research of immunological vaccines. Sequence: 5'-tcgtcgttttcggcgc:gcgccg-3' (Note: The bases are phosphorothioate; ODN 2395 contains the partial palindromic sequence cggcgc:gcgccg)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1254617-22-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-150743. | |
| ODN M362 | ODN M362, a class C oligodeoxynucleotide, is a TLR-9 agonist and can be used as a vaccine adjuvant. ODN M362 induces cancer cell apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 934655-87-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-150750. | |
| ODN TTAGGG | ODN TTAGGG (ODN A151), an inhibitory oligonucleotide (ODN), is a TLR9, AIM2, and cGAS antagonist. ODN TTAGGG inhibits AIM2 inflammasome activation and cGAS activation through competition with DNA. ODN TTAGGG blocks AIM2-mediated Pyroptosis and inhibits IL-18 production. ODN TTAGGG has immunosuppressive effects and can be used in research on related autoimmune diseases such as lupus erythematosus[1][2][3]. ODN TTAGGG sequence: 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3'. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ODN A151. CAS No. 1801724-76-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-150751. | |
| Odoroside A | Odoroside A is an active ingredient extracted from the leaves of Nerium oleander Linn. Odoroside A has anti-cancer activity. Odoroside A could induce apoptosis and cell cycle arrest through ROS/p53 signaling pathway, leading to the tumor cell death[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 12738-19-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N7496. | |
| ODQ | ODQ is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 41443-28-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101255. | |
| Odronextamab | Odronextamab is a stable humanized IgG4 CD20?×?CD3 bispecific antibody that binds to CD3 on T cells and CD20 on B cells, triggering anti-tumor activity. Odronextamab is expected to be used in oncology research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REGN1979. CAS No. 1801338-64-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99038. | |
| Oenothein B | Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 104987-36-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N7765. | |
| OF-02 | OF-02 is an ionizable lipid for mRNA delivery and a key component of lipid nanoparticles (LNPs). OF-02 is protonated in the acidic endosomal environment to promote endosomal escape of mRNA and efficiently induce protein expression in target cells. OF-02 relies on the pH-responsive membrane fusion properties to form a complex with mRNA and destroy the endosomal membrane structure to achieve mRNA release in the cytoplasm. OF-02 is mainly used in the development of mRNA vaccines, gene editing, and protein replacement therapy[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1883431-67-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145795. | |
| OF-1 | OF-1, a chemical probe, is a potent pan-BRPF bromodomain (BRD) inhibitor, with IC50 values of 270 nM, 1.2 μM for TRIM24 and BRPF1B, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 919973-83-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12518. | |
| Ofatumumab | Ofatumumab is a fully human anti-CD20 monoclonal antibody that induces antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) in CD20-expressing B lymphocytes. Ofatumumab has strong lytic activity against CD20-positive B lymphocytes and eliminates CD20-positive tumor cells through ADCC and CDC. Ofatumumab is particularly effective against drug-resistant cells with low CD20 expression and can be applied to the research of chronic lymphocytic leukemia (CLL)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK1841157; OMB-157. CAS No. 679818-59-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9961. | |
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