MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| (R)-ZINC-3573 | (R)-ZINC-3573 is a selective Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist with an EC50 value of 740 nM. (R)-ZINC-3573 can be used as a MRGPRX2 probe for the research of pain and itch[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2089389-15-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-118069. |  |
| S07-2010 | S07-2010 is a potent pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC50 values of 0.19, 0.36, 0.47, and 0.73 μM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2, respectively. S07-2010 induces apoptosis in A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1223194-71-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150644. | |
| S0859 | S0859 is a selective, high-affinity generic Na+/HCO3- transporter (NBC) inhibitor. S0859 reversibly inhibits NBC-mediated intracellular pH (pHi) recovery (Ki=1.7 μM, full inhibition at approximately 30 μM). Uses: Scientific research. Category: Signaling pathways. CAS No. 1019331-10-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-15529. | |
| S100P-IN-1 | S100P-IN-1 (Compound 4) is a S100P inhibitor with an IC50 of 22.7 nM. S100P-IN-1 shows anti-metastatic effects on pancreatic cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 690991-06-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146695. | |
| S107 | S107 is an orally available, blood brain barrier-permeable compound, which stabilizes RyR2 channels by enhancing the binding of calstabin 2 to the mutant Ryr2-R2474S channel. S107 inhibits Ca2+ leakage from the sarcoplasmic reticulum (SR) and prevents cardiac arrhythmias and raises the seizure threshold[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 927871-76-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15292. | |
| S130 | S130 is a high affinity, selective inhibitor of ATG4B (a major cysteine protease) with an IC50 of 3.24 μM. S130 suppresses autophagy flux[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1160852-22-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112818. | |
| S-14506 hydrochloride | S-14506 hydrochloride is a potent 5-HT1A agonist, as well as 5-HT2A/2C antagonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 286369-38-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110024. | |
| S 17092 | S 17092 (S 17092-1) is an orally active cerebral prolyl-endopeptidase (PEP) inhibitor with an IC50 of 1.2 nM. S 17092 inhibits cell apoptosis. S 17092 mechanism of action is to inhibit the activity of PEP, slowing down the degradation of neuroactive peptides and thus enhancing memory function. S 17092 can be used for the research of memory impairment and cognitive disorders associated with cerebral aging[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S 17092-1. CAS No. 176797-26-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15114. | |
| S 18986 | S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. S 18986 shows cognitive enhancing properties in rodents. S 18986 activates the release of noradrenaline and acetylcholine in rat hippocampus and enhances rat memory in object-recognition tests[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 175340-20-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10936. | |
| (S)-1-Benzylpyrrolidin-3-ol | (S)-1-Benzylpyrrolidin-3-ol (Compound 14) can be used to synthesis impurities of the anti-hypertensive agent Barnidipine hydrochloride (HY-107322)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 101385-90-4. Pack Sizes: 5 g; 10 g; 25 g. Product ID: HY-W016644. | |
| S1PL-IN-1 | S1PL-IN-31 (compound ) is an oral active sphingosine-1-phosphate (S1P) lyase inhibitor with the IC50 of 210 nM. S1PL-IN-31 is Smoothened receptor antagonist with the IC50 of 440 nM. S1PL-IN-31 can be used for study of experimental autoimmune encephalomyelitis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1538574-95-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-115566. | |
| S-1-Propenyl-L-cysteine | S-1-Propenyl-L-cysteine is a stereoisomer of S-allyl-l-cysteine, extracted from garlic, with immunomodulatory effects and reduces blood pressure in a hypertensive animal model[1]. S-1-Propenyl-L-cysteine exhibits antioxidative efficacy through a NO-dependent BACH1 signaling pathway[2]. S-1-Propenyl-L-cysteine is orally active. Uses: Scientific research. Category: Signaling pathways. CAS No. 52438-09-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111827. | |
| S1QEL1.1 | S1QEL1.1 is a small molecule inhibitor that specifically inhibits the generation of superoxide and hydrogen peroxide at the IQ site during reverse electron transfer in mitochondrial respiratory chain complex I (Complex I), with an IC50 of 0.07 μM. S1QEL1.1 can significantly reduce the activation of cysteine-aspartic protease (caspase) triggered by endoplasmic reticulum stress. S1QEL1.1 helps to decrease excessive proliferation of stem cells by inhibiting the Reactive Oxygen Species signaling pathway initiated by endoplasmic reticulum stress[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 897613-29-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-129115. | |
| S1RA | S1RA (E-52862) is a highly selective σ1 receptor (σ1R) antagonist with Kis of 17 nM and 23.5 nM for human σ1R and guinea pig σ1R, respectively. S1RA has Moderate antagonistic activity for human 5-HT2B receptor (Ki= 328 nM). S1RA has antinociceptive effects in neuropathic pain models. S1RA prevents mechanical and cold hypersensitivity in Oxaliplatin (HY-17371)-treated mice[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: E-52862. CAS No. 878141-96-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-18099. | |
| S1RA hydrochloride | S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (Ki >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: E-52862 hydrochloride. CAS No. 1265917-14-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-18099A. | |
| S-22153 | S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 180304-07-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114962. | |
| S26131 | S26131 (compound 5) is a potent and selective MT1 melatoninergic ligand, and the Ki values are 0.5 and 112 nM for MT1 and MT2, respectively. S26131 behaves as an MT1 and MT2 antagonist[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 296280-56-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-122136. | |
| S29434 | S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. S29434 induces autophagy and inhibits QR2-mediated ROS production[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NMDPEF. CAS No. 874484-20-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122614. | |
| (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-cyanophenyl)propanoic acid | (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-cyanophenyl)propanoic acid is a phenylalanine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 205526-36-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g. Product ID: HY-W010958. | |
| (S)-2-amino-3-(4-benzoylphenyl)propanoic acid | (S)-2-amino-3-(4-benzoylphenyl)propanoic acid is an alanine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 104504-45-2. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g. Product ID: HY-W000795. | |
| (S)-2-Amino-3-(4-(tert-butoxy)phenyl)propanoic acid | (S)-2-Amino-3-(4-(tert-butoxy)phenyl)propanoic acid is a tyrosine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 18822-59-8. Pack Sizes: 10 g; 25 g; 100 g. Product ID: HY-W012133. | |
| (s)-2-Amino-5-methoxytetralin hydrochloride | (s)-2-Amino-5-methoxytetralin hydrochloride is a drug intermediate for synthesis of various active compounds. Uses: Scientific research. Category: Signaling pathways. CAS No. 58349-17-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-I0016. | |
| (S)-2-Hydroxybutanoic acid | (S)-2-Hydroxybutanoic acid is the S-enantiomer of 2-Hydroxybutanoic acid. 2-Hydroxybutanoic acid, a coproduct of protein metabolism, is an insulin resistance (IR) biomarker[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3347-90-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-W018499. | |
| (S)-(-)-2-Methylbutanol | (S)-(-)-2-Methylbutanol is a S-isomer of 2-Methylbutanol[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-2-Methyl-1-butanol. CAS No. 1565-80-6. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 50 g; 100 g; 500 g. Product ID: HY-W093104. | |
| (S)-3-(4-Aminophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid | (S)-3-(4-Aminophenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid is a phenylalanine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55533-24-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g. Product ID: HY-W007620. | |
| (S)-3,4-DCPG | (S)-3,4-DCPG is a selective agonist of metabotropic glutamate receptor 8a (mGluR8a) with an EC50 of 31 nM in AV12-664 cells expressing human mGluR8[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-3,4-Dicarboxyphenylglycine. CAS No. 201730-11-2. Pack Sizes: 5 mg. Product ID: HY-107516. | |
| (S)-3,5-DHPG | (S)-3,5-DHPG is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with Ki values of 0.9 μM and 3.9 μM for mGluR1a and mGluR5a, respectively[1]. (S)-3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 162870-29-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-12598. | |
| S 38093 | S 38093 is a brain-penetrant, orally active antagonist of H3 receptor, with Kis of 8.8, 1.44 and 1.2 μM for rat, mouse and human H3 receptors, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 862896-30-8. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-104003. | |
| S3969 | S3969 is a potent and reversible activator of the human epithelial sodium channel (hENaC). The apparent EC50 for S3969 activation of hENaC is 1.2 μm[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1027997-01-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112472. | |
| (S)-3-Hydroxy Midostaurin | (S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et). (S)-3-Hydroxy Midostaurin is a minor metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (S)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-CGP52421. CAS No. 945260-14-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108263A. | |
| S3I-1757 | S3I-1757 is a STAT3 inhibitor. S3I-1757 inhibits the phosphorylation and dimerization of STAT3. S3I-1757 can be used for the research of STAT3 hyperactive cancers such as melanoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1456602-51-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100610. | |
| S3QEL-2 | S3QEL-2, a suppressor of superoxide production from mitochondrial complex III, potently and selectively suppresses site IIIQo superoxide production (IC50=1.7 μM). S3QEL-2 does not affect oxidative phosphorylation, and normal electron flux. S3QEL-2 inhibits HIF-1α accumulation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 890888-12-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110282. | |
| S55746 | S55746 (BCL201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BCL201) has antitumor activity with low toxicity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BCL201. CAS No. 1448584-12-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117288. | |
| S55746 hydrochloride | S55746 hydrochloride (BCL201 hydrochloride) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 hydrochloride (BCL201 hydrochloride) has antitumor activity with low toxicity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BCL201 hydrochloride. CAS No. 1448525-91-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117288A. | |
| S63845 | S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1799633-27-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100741. | |
| S65487 | S65487 (VOB560), a potent and selective BCL-2 inhibitor, is a proagent of S55746. S65487 is also active on BCL-2 mutations, such as G101V and D103Y. S65487 has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 induces apoptosis and has anticaner activities[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VOB560. CAS No. 1644600-79-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-138697. | |
| S65487 hydrochloride | S65487 (VOB560) hydrochloride, a potent and selective Bcl-2 inhibitor, is a proagent of S55746. S65487 hydrochloride is also active on BCL-2 mutations, such as G101V and D103Y. S65487 hydrochloride has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 hydrochloride induces apoptosis and has anticaner activities[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VOB560 hydrochloride. CAS No. 1644543-95-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138697B. | |
| S65487 sulfate | S65487 (VOB560) sulfate, a potent and selective Bcl-2 inhibitor, is a proagent of S55746. S65487 sulfate is also active on BCL-2 mutations, such as G101V and D103Y. S65487 sulfate has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 sulfate induces apoptosis and has anticaner activities[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VOB560 sulfate. CAS No. 2416937-01-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138697A. | |
| S6821 | S6821 is a TAS2R8 antagonist with IC50 value of 0.035 μM. S6821 is not found to be mutagenic or disruptive in vitro, nor is it found to induce micronucleus in bone marrow polychromatic erythrocytes in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1119831-25-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-139899. | |
| S6K2-IN-1 | S6K2-IN-1 (Compound 2) is a S6K2 inhibitor (IC50: 22 nM). S6K2-IN-1 also inhibits FGFR4 (IC50: 216 nM). S6K2-IN-1 has acceptable stability in mouse liver microsomes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3053678-93-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156672. | |
| S7 | S7 is an IL-6 receptor antagonist and inhibits the binding between IL-6 and IL-6R. S7 can inhibit angiogenesis and tumor growth[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 853248-13-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10284. | |
| S961 | S961 is an high-affinity and selective insulin receptor (IR) antagonist with IC50s of 0.048, 0.027, and 630 nM for HIR-A, HIR-B, and human insulin-like growth factor I receptor (HIGF-IR) in SPA-assay, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1083433-49-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2093. | |
| S9-A13 | S9-A13 is a potent and selective inhibitor SLC26A9, with the IC50 of 90.9 nM, without inhibiting other members of the SLC26 family such as SLC26A3, SLC26A4, and SLC26A6. S9-A13 can inhibits SLC26A9 Cl- currents in cells that lack expression of CFTR[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1223771-84-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-159706. | |
| Sabatolimab | Sabatolimab (MBG453) is a high-affinity, humanized, IgG4 (S228P) antibody targeting TIM-3, an inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab is a potential immunosuppression agent that can target TIM-3 on immune and myeloid cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MBG453. CAS No. 2252262-24-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99044. | |
| Sabinene | Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways[1][2]. Uses: Scientific research. Category: Natural products. CAS No. 3387-41-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-108943. | |
| Sabirnetug | Sabirnetug is a humanized IgG2κ antibody targeting the Amyloid-β A4 precursor protein. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ACU-193. CAS No. 2747959-38-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990011. | |
| Sabutoclax | Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC50s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively. Sabutoclax increases Bax, Bim, PUMA and survivin expression[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BI-97C1. CAS No. 1228108-65-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-15191. | |
| Saccharin | Saccharin is an orally active, non-caloric artificial sweeteners (NAS). Saccharin has bacteriostatic and microbiome-modulating properties[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 81-07-2. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 50 g. Product ID: HY-Y0272. | |
| Saccharin sodium | Saccharin sodium is an orally active, non-caloric artificial sweetener (NAS). Saccharin sodium has bacteriostatic and microbiome-modulating properties. Saccharin binds to and signals via specific taste receptors, not only in the oral cavity but also alongside the gastrointestinal tract. Saccharin has been reported to bind the human and rodent heteromeric guanine nucleotide-binding protein (G protein) coupled sweet taste receptors T1R2/T2R3 as well as the human bitter taste receptor T2R43 and T2R44. Saccharin can inhibit bacterial growth in vitro[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 128-44-9. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g. Product ID: HY-B1390A. | |
| Saccharopine | Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L-Saccharopine. CAS No. 997-68-2. Pack Sizes: 1 mg. Product ID: HY-W040307. | |
| S-(Acetamidomethyl)-N-(tert-butoxycarbonyl)-L-cysteine | S-(Acetamidomethyl)-N-(tert-butoxycarbonyl)-L-cysteine is a cysteine derivative[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 19746-37-3. Pack Sizes: 10 mM * 1 mL in DMSO; 25 g; 100 g. Product ID: HY-W004153. | |
| S-Acetyl-PEG3-azide | S-Acetyl-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. S-Acetyl-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1310827-26-9. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-140859. | |
| S-acetyl-PEG4-propargyl | S-acetyl-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1422540-88-2. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-141350. | |
| Sacituzumab | Sacituzumab is a humanized IgG1 monoclonal antibody targeting Trophoblast cell surface antigen 2 (TROP2). Sacituzumab demonstrates a lack of antitumor effects alone and does not inhibit the function of TROP-2 during tumor metastasis, binding to the linear epitopes of TROP-2 protein. Sacituzumab can be used for the synthesis of antibody-drug conjugates (ADC) drug Sacituzumab govitecan (HY-132254). Sacituzumab govitecan can be used in the field of triple-negative breast cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HRS7; hRS7. CAS No. 1796566-95-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P99045. | |
| Sacituzumab govitecan | Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. The antibody portion is Sacituzumab (HY-P99045), and the drug-linker conjugate for ADC is CL2A-SN-38 (HY-128946). Sacituzumab govitecan shows anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IMMU-132. CAS No. 1491917-83-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-132254. | |
| Sacituzumab govitecan (solution) | Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. The antibody portion is Sacituzumab (HY-P99045), and the drug-linker conjugate for ADC is CL2A-SN-38 (HY-128946). Sacituzumab govitecan shows anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IMMU-132 (solution). CAS No. 1491917-83-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132254A. | |
| Sacituzumab tirumotecan | Sacituzumab tirumotecan is an antibody-drug conjugate and TROP2-directed, topoisomerase I inhibitor payload-delivering agent, with a TROP2 EC50 of 2.787 ng/ml, TROP2 Ka of 0.3083 nM, and topoisomerase I IC50 of 0.7 μmol/L. Sacituzumab tirumotecan can be used for the research of metastatic triple-negative breast cancer, and metastatic non-small cell lung cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SKB264; MK-2870. CAS No. 2768350-77-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-164789. | |
| SACLAC | SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase (ASAH1; AC) inhibitor with a Ki of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2248703-42-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158783. | |
| Saclofen | Saclofen is an orally active and a competitive GABAB receptor antagonist with an IC50 of 7.8 μM. Saclofen has weak antagonistic effects on GABAB1b and GABAB2 heterodimeric recombinant receptors. Saclofen inhibits the binding of Baclofen (HY-B0007) to rat cerebellar membranes and blocks Baclofen-induced circadian phase shifts, and exhibits anti-inflammatory and analgesic effects in rats[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 125464-42-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100813. | |
| Sacubitril | Sacubitril (AHU-377) is a potent and orally active NEP (neprilysin) inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. Sacubitril can be used for the research of heart failure, hypertension and COVID-19[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AHU-377. CAS No. 149709-62-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-15407. | |
| Sacubitrilat | Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Desethyl Sacubitril; LBQ-657. CAS No. 149709-44-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17620. | |
| Sacubitril sodium | Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AHU-377 sodium. CAS No. 149690-05-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15407B. | |
| Sacubitril/Valsartan | Sacubitril/Valsartan (LCZ696), comprised Valsartan and Sacubitril (AHU377) in 1:1 molar ratio, is a first-in-class, orally bioavailable, and dual-acting angiotensin receptor-neprilysin (ARN) inhibitor for hypertension and heart failure[1][2][3]. Sacubitril/Valsartan ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress and apoptosis[4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LCZ696. CAS No. 936623-90-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-18204A. | |
| S-Adenosyl-L-ethionine | S-Adenosyl-L-ethionine is S-Adenosyl-L-methione analog. S-Adenosyl-L-ethionine is able to replace S-Adenosyl-L-methione during HydG catalysis. HydG can utilize S-Adenosyl-L-ethionine as an effective alternative cosubstrate to S-Adenosyl-L-methione under normal enzymatic turnover conditions, producing the Ω intermediate and allowing efficient catalytic turnover of substrate L-tyrosine[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 524-70-9. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg. Product ID: HY-160963. | |
| S-Adenosyl-L-methionine | S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti - proliferative, pro - apoptotic and anti - metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-Adenosyl methionine; Ademetionine; AdoMet. CAS No. 29908-03-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0617. | |
| S-Adenosyl-L-methionine-13C | S-Adenosyl-L-methionine-13C (S-Adenosyl methionine-13C) is the 13C labeled S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine (S-Adenosyl methionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects, and has the potential for liver disease and osteoarthritis research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-Adenosyl methionine-13C; Ademetionine-13C; AdoMet-13C. CAS No. 74084-24-5. Pack Sizes: 1 mg. Product ID: HY-B0617S1. | |
| S-Adenosyl-L-methionine chloride dihydrochloride | S-Adenosyl-L-methionine (S-Adenosyl methionine) chloride dihydrochloride is an orally active methyl group donor. S-Adenosyl-L-methionine chloride dihydrochloride is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine chloride dihydrochloride also has anti - proliferative, pro - apoptotic and anti - metastatic roles in cancers. S-Adenosyl-L-methionine chloride dihydrochloride has the potential for, cancer, liver disease and osteoarthritis research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-Adenosyl methionine chloride dihydrochloride; Ademetionine chloride dihydrochloride; AdoMet chloride dihydrochloride. CAS No. 86867-01-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14614A. | |
| S-Adenosyl-L-methionine-d3 | S-Adenosyl-L-methionine-d3 (S-Adenosyl methionine-d3) is the deuterated product of S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti - proliferative, pro - apoptotic and anti - metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-Adenosyl methionine-d3; Ademetionine-d3; AdoMet-d3. CAS No. 68684-40-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-B0617S. | |
| S-Adenosyl-L-methionine disulfate tosylate | S-Adenosyl-L-methionine (Ademetionine) disulfate tosylate is the disulfate tosylate form of S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine disulfate tosylate is an orally active methyl group donor. S-Adenosyl-L-methionine disulfate tosylate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine disulfate tosylate also has anti - proliferative, pro - apoptotic and anti - metastatic roles in cancers. S-Adenosyl-L-methionine disulfate tosylate has the potential for, cancer, liver disease and osteoarthritis research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ademetionine disulfate tosylate; S-Adenosyl methionine disulfate tosylate; AdoMet disulfate tosylate. CAS No. 97540-22-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg. Product ID: HY-W017770. | |
| S-Adenosyl-L-methionine tosylate | S-Adenosyl-L-methionine (S-Adenosyl methionine) tosylate is an orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine tosylate also has anti - proliferative, pro - apoptotic and anti - metastatic roles in cancers. S-Adenosyl-L-methionine tosylate has the potential for, cancer, liver disease and osteoarthritis research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-Adenosyl methionine tosylate; Ademetionine tosylate; AdoMet tosylate. CAS No. 52248-03-0. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg; 500 mg. Product ID: HY-B0617A. | |
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