MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| (R)-Mirtazapine | (R)-Mirtazapine ((R)-Org3770) is a R(-)-enantiomer of Mirtazapine with antinociceptive properties in an animal model of acute thermal nociception. (R)-Mirtazapine is a 5-HT 3 receptor antagonist. (R)-Mirtazapine is mainly metabolized by CYP3A4 [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (R)-Org3770; (R)-6-Azamianserin. CAS No. 61364-37-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B0352B. |  |
| RN-1734 | RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4?PDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 ?M, mTRPV4: 5.9 ?M, rTRPV4: 3.2 ?M)[1]. RN-1734 clearly decreases the production of tumor necrosis factor ? (TNF-?) and interleukin 1? (IL-1?) without altering the number of olig2-positive cells[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 946387-07-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19975. | |
| RN-1 dihydrochloride | RN-1 dihydrochloride is a potent, brain-penetrant, irreversible and selective lysine-specific demethylase 1 (LSD1) inhibitor with an IC 50 of 70 nM. RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC 50 values of 0.51 μM and 2.785 μM respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1781835-13-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-110130. | |
| RN-9893 | RN-9893 is a potent and selective TRPV4 receptor antagonist with IC 50 values of 320, 420 and 660 nM for mouse, human and rat channels, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1803003-68-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-110270. | |
| RNA Aptamer Broccoli sodium | RNA Aptamer Broccoli (sodium) is a 49-nt-long aptamer that is substantially shorter than Spinach and Spinach2 and exhibits bright green fluorescence upon binding DFHBI or DFHBI-1T (soluble analogs of the fluorophore of green fluorescent protein). RNA Aptamer Broccoli (sodium) can be used to visualize RNA expression or localization in live cells. In vitro Broccoli exhibits a similar high folding efficiency as Spinach2, but exhibits markedly lower dependence on magnesium for folding and increased thermostability. Additionally, unlike Spinach2, Broccoli does not require the use of a tRNA scaffold to promote its folding in vivo. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 1 mg; 5 mg. Product ID: HY-153845. | |
| RNase A (10mg/mL, DNase free) | RNase A (10mg/mL, DNase free) is a ribonuclease used to catalyze RNA degradation without containing DNase. RNase A is often employed in cell cycle assay[1][2]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 1 mL. Product ID: HY-129046A. | |
| RNase A, Bovine pancreas | RNase A, Bovine pancreas (Ribonuclease A) cleaves the 3' end of RNA to pyrimidine and actively cleaves RNA at each pyrimidine residue. RNase A, bovine pancreas catalyzes the hydrolysis of single-stranded RNA in the absence of metal ions or cofactors [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ribonuclease A; EC 4.6.1.18; RNase A. CAS No. 9001-99-4. Pack Sizes: 25 mg; 50 mg. Product ID: HY-129046. | |
| RNase B, Bovine Pancreas | RNase B, Bovine Pancreas is an N-glycosylated form of bovine pancreatic ribonuclease, which is structurally analogous to RNase A. RNase B, Bovine Pancreas promotes the folding of polypeptide chains and performs a chaperone-like function[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ribonuclease B, Bovine Pancreas. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-129046C. | |
| (R)-(-)-N-Boc-3-pyrrolidinol | (R)-(-)-Boc-3-pyrrolidinol is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 109431-87-0. Pack Sizes: 25 g; 50 g. Product ID: HY-W001294. | |
| RNPA1000 | RNPA1000, an antibiotic , is a potent RnpA inhibitor and inhibits RnpA-mediated cellular RNA degradation. RNPA1000 inhibits tRNA maturation with an IC 50 of 175 μM. RNPA1000 displays broad-spectrum antimicrobial activities and inhibits staphylococcal and all Gram-positive bacterial pathogens activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 359600-10-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-12824. | |
| Ro 08-2750 | Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 ?M. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA[1]. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 ?M[3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 37854-59-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108466. | |
| RO1138452 | RO1138452 is a potent and selective IP (prostacyclin) receptor antagonist. RO1138452 displays high affinity for IP receptors. In human platelets, pKi is 9.3±0.1; in a recombinant IP receptor system, pKi is 8.7±0.06. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CAY10441. CAS No. 221529-58-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108912. | |
| Ro15-4513 | Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR) [1]. Ro15-4513 is a potent ethanol antagonist [2]. Ro15-4513 has anti-anxiety effect [3]. Ro15-4513 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 91917-65-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103476. | |
| Ro 20-1724 | Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 20-174. CAS No. 29925-17-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100927. | |
| Ro24-7429 | Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 139339-45-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19149. | |
| Ro 25-6981 | Ro 25-6981 is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 has the potential for the research of parkinson's disease (PD) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 169274-78-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-13993. | |
| Ro 25-6981 Maleate | Ro 25-6981 Maleate is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 Maleat shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 Maleate has the potential for the research of parkinson's disease (PD) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1312991-76-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13993A. | |
| RO-3 | RO-3 is a potent, CNS-penetrant, and orally active P2X 3 and P2X 2/3 antagonist with pIC 50 s of 5.9 and 7.0 for human homomultimeric P2X 3 and heteromultimeric P2X 2/3 receptors, respectively. RO-3 shows selectivity for P2X 3 and P2X 2/3 over all other functional homomultimeric P2X receptors (IC 50 >10 μM at P2X 1,2,4,5,7 ) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1026582-88-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19978. | |
| Ro 31-8220 mesylate | Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKC?, PKC?I, PKC?II, PKC?, PKC? and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3? (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 mesylate can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC[1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro 31-8220 methanesulfonate; Bisindolylmaleimide IX mesylate. CAS No. 138489-18-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13866. | |
| RO3201195 | RO3201195 (compound 1) is an inhibitor of p38 MAPK. RO3201195 inhibits WS cell proliferation with IC 50 value of 190 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 249937-52-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-118612. | |
| RO3244794 | RO3244794 is a potent and selective IP (prostacyclin) receptor antagonist, with a pK i of 7.7 and 6.9 in human platelet and recombinant IP receptor system, respectively. RO3244794 exhibits analgesic and anti-inflammatory potential [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 361457-01-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-164580. | |
| Ro-3306 | Ro-3306 is a potent and selective inhibitor of CDK1, with Kis of 20 nM, 35 nM and 340 nM for CDK1, CDK1/cyclin B1 and CDK2/cyclin E, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 872573-93-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12529. | |
| Ro 363 hydrochloride | Ro 363 hydrochloride, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 250580-70-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-123268A. | |
| Ro 41-5253 | Ro 41-5253 is an orally active selective retinoic acid receptor alpha (RAR?) antagonist. Ro 41-5253 can bind RAR? without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding. Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 144092-31-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116248. | |
| Ro 48-8071 fumarate | Ro 48-8071 fumarate is an inhibitor of OSC (Oxidosqualene cyclase) with IC 50 of appr 6.5 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 189197-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18630A. | |
| RO4929097 | RO4929097 (RG-4733) is an orally active ? secretase inhibitor with an IC50 of 4 nM, inhibiting cellular processing of A?40 and Notch with EC50 of 14 nM and 5 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RG-4733. CAS No. 847925-91-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11102. | |
| Ro5-3335 | Ro5-3335, a benzodiazepine, acts as an inhibitor of core binding factor (CBF) leukemia. Ro5-3335 is a RUNX1-CBF? interaction inhibitor that represses RUNX1/CBFB-dependent transactivation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 30195-30-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-108470. | |
| RO5454948 | Mirk-IN-1 (Dyrk1B/A-IN-1) is a highly efficient and selective inhibitor of Dyrk1B and Dyrk1A, with IC50 values of 68 and 22nM respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Mirk-IN-1; Dyrk1B/A-IN-1. CAS No. 1386979-55-0. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-12838. | |
| Ro60-0175 | Ro60-0175 is a potent and selective agonist of 5-HT 2C receptor. Ro60-0175 reduces self-administration [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 169675-08-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123838. | |
| Ro60-0175 fumarate | Ro60-0175 fumarate is a potent and selective agonist of 5-HT 2C receptor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 169675-09-6. Pack Sizes: 10 mM * 1 mL; 5 mg. Product ID: HY-103140. | |
| Ro 61-8048 | Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC50 of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 199666-03-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-12347. | |
| Ro 64-6198 | Ro 64-6198 is a potent, selective, nonpeptide, high-affinity, high cellular permeability and brain penetration N/OFQ receptor (NOP) agonist with an EC 50 value of 25.6 nM. Ro 64-6198 is at least 100 times more selective for the NOP receptor over the classic opioid receptors. Ro 64-6198 can be used for stress and anxiety, addiction, neuropathic pain, cough, and anorexia [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 280783-56-4. Pack Sizes: 10 mM * 1 mL; 5 mg. Product ID: HY-12844. | |
| Ro 67-7476 | Ro 67-7476 is a potent positive allosteric modulator of mGluR 1 and potentiates glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a with an EC 50 of 60.1 nM [1] [2]. Ro 67-7476 is a potent P-ERK1/2 agonist and activates ERK1/2 phosphorylation in the absence of exogenously added glutamate ( EC 50 =163.3 nM) [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 298690-60-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100403. | |
| RO6806051 | RO6806051 (compound12) is a potent dual fatty acid binding protein 4 and 5 (FABP4 and FABP5) inhibitor with good selectivity and absorption, distribution, metabolism and excretion (eADME) properties[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1433901-75-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161702. | |
| Robatumumab | Robatumumab (Sch 717454) is an anti-human IGF-1R ( insulin-like growth factor receptor-1 ) antibody. Robatumumab shows anti-tumor activity and anti-proliferative activity to cancer cells. Robatumumab can be used in osteosarcoma and Ewing sarcoma research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Sch 717454; 19D12. CAS No. 934235-44-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99218. | |
| Robenacoxib | Robenacoxib is a nonsteroidal anti-inflammatory and analgesic agent. Robenacoxib is a selective COX-2 inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 220991-32-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-118078. | |
| Robenidine hydrochloride | Robenidine hydrochloride is an anticoccidial agent which is also active against MRSA and VRE with MIC 50 s of 8.1 and 4.7 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 25875-50-7. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B2157. | |
| Roblitinib | Roblitinib (FGF-401) is an orally active and highly selective FGFR4 inhibitor with an IC 50 of 1.9 nM [1]. Roblitinib has antitumor activity [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FGF-401. CAS No. 1708971-55-4. Pack Sizes: 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101568. | |
| ROC-325 | ROC-325 is a potent and orally active autophagy inhibitor with a strong anticancer activity. ROC-325 induces the deacidification of lysosomes, accumulation of autophagosomes, and disrupted autophagic flux. ROC-325 also induces renal cell carcinoma apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1859141-26-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103706. | |
| Rocaglamide | Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-?B activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia[1][2][3]. Uses: Scientific research. Group: Natural products. Alternative Names: Roc-A. CAS No. 84573-16-0. Pack Sizes: 10 mM * 1 mL; 500 ?g; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19356. | |
| Rocatinlimab | Rocatinlimab (AMG 451) (KHK4083) is a fully human, non-fucosylated, immunoglobulin G1 (IgG1) anti-OX40 monoclonal antibody. Rocatinlimab can be used for the research of atopic dermatitis (AD) [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AMG 451; KHK4083. CAS No. 2431972-52-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99955. | |
| Rochelle salt | Rochelle salt is an organic-inorganic compound commonly used as a catalyst and complexing reagent. It can be used to catalyze or promote certain chemical reactions, and is widely used in batteries, pharmaceuticals and food industries. In addition, this compound is also used as a substrate or intermediate in some biochemical reactions. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: L-Tartaric acid potassium sodium salt tetrahydrate; Potassium sodium tartrate tetrahydrate; Sodium potassium tartrate tetrahydrate. CAS No. 6381-59-5. Pack Sizes: 25 g; 100 g. Product ID: HY-Y1332. | |
| Rociletinib | Rociletinib (CO-1686) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the K i values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CO-1686; AVL-301; CNX-419. CAS No. 1374640-70-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15729. | |
| Rociletinib hydrobromide | Rociletinib hydrobromide (CO-1686 hydrobromide) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the K i values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CO-1686 hydrobromide; AVL-301 hydrobromide; CNX-419 hydrobromide. CAS No. 1446700-26-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15729A. | |
| ROCK2-IN-6 hydrochloride | ROCK2-IN-6 hydrochloride (Comp A) is a selective ROCK2 inhibitor, can be used for ROCK mediated diseases, autoimmune diseases and inflammation research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2762238-94-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156592A. | |
| ROCK-IN-1 | ROCK-IN-1 is a potent inhibitor of ROCK , with an IC 50 of 1.2 nM for ROCK2. Uses: Scientific research. Group: Signaling pathways. CAS No. 934387-35-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00351. | |
| ROCK-IN-5 | ROCK-IN-5 (compound I-B-37) is a potent inhibitor of ROCK , ERK , GSK , and AGC protein kinases. ROCK-IN-5 has the potential for proliferative, cardiac and neurodegenerative diseases research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 692870-25-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-153011. | |
| ROCK inhibitor-2 | ROCK inhibitor-2 (compound 6) is a selective dual inhibitor of ROCK1 and ROCK2, with IC50 values of 160 nM and 21 nM, respectively. ROCK inhibitor-2 inhibits pMYPT1 with IC50 of 75 nM. ROCK inhibitor-2 exhibits antitumor activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1127308-52-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119937. | |
| Rocuronium Bromide | Rocuronium Bromide (ORG 9426 Bromide) is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal musclerelaxation during surgery or mechanical ventilation. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ORG 9426 Bromide. CAS No. 119302-91-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-17440. | |
| Rodatristat | Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC 50 s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KAR5417. CAS No. 1673568-73-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-120083. | |
| Rodatristat ethyl | Rodatristat ethyl (KAR5585) is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KAR5585. CAS No. 1673571-51-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101124. | |
| Rofapitide tetraxetan | Rofapitide tetraxetan (FAP-2286) is a potent and selective FAP-binding peptide with a mean IC 50 value of 2.7 nM for binding to FAP. Rofapitide tetraxetan can be labeled with radionuclides for diagnostic applications. Rofapitide tetraxetan has antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FAP-2286. CAS No. 2581741-18-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-147057. | |
| Rofecoxib | Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC 50 s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC 50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells). Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK 966. CAS No. 162011-90-7. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-17372. | |
| Roflumilast | Roflumilast (APTA-2217) is a selective PDE4 inhibitor with IC 50 s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1 , PDEA4 , PDEB1 , and PDEB2 , respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: APTA-2217; BYK 20869; B9302-107. CAS No. 162401-32-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15455. | |
| Rogaratinib | Rogaratinib (BAY1163877) is a potent and selective fibroblast growth factor receptor ( FGFR ) inhibitor. Rogaratinib inhibits FGFRs with IC50s of 11.2 nM (FGFR1), <1 nM (FGFR2), 18.5 nM (FGFR3), 127 nM (VEGFR3/FLT4), 201 nM (FGFR4), respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY1163877. CAS No. 1443530-05-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100019. | |
| Roginolisib | Roginolisib (MSC2360844; IOA-244) is a potent, orally active and selective PI3Kδ inhibitor, with an IC 50 of 145 nM. Roginolisib shows highly selective against a panel of 278 additional kinases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MSC2360844; IOA-244. CAS No. 1305267-37-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135827. | |
| Rohinitib | Rohinitib is a potent and specific eIF4A inhibitor. Rohinitib induces cell apoptosis of acute myeloid leukemia (AML) cell lines and reduces the leukemia burden of AML xenograft model. Rohinitib can be used for the research of AML[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1139253-73-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148422. | |
| (R)-Olacaftor | (R)-Olacaftor ((R)-VX-440) is a Cystic fibrosis transmembrane conductance regulator ( CFTR ) modulator. (R)-Olacaftor has good potential for the study of cystic fibrosis (CF) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (R)-VX-440. CAS No. 1899111-41-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-112267A. | |
| Rolapitant | Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K i of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SCH619734. CAS No. 552292-08-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14751. | |
| Rolapitant hydrochloride hydrate | Rolapitant hydrochloride hydrate (SCH619734 hydrochloride hydrate) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K i of 0.66 nM. Rolapitant hydrochloride hydrate does not interact with CYP3A4. Rolapitant hydrochloride hydrate shows potent anti-emetic activity in a ferret emesis model [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SCH619734 hydrochloride hydrate. CAS No. 914462-92-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16436. | |
| Rolipram | Rolipram is a selective phosphodiesterases PDE4 inhibitor with IC 50 s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (R,S)-Rolipram; (±)-Rolipram; ZK 62711. CAS No. 61413-54-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16900. | |
| Rolitetracycline | Rolitetracycline, a derivative of tetracycline, is a broad-spectrum antibiotic [1] [2]. Rolitetracyclin has a role as a protein synthesis inhibitor, an antiprotozoal agent and a proagent [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 751-97-3. Pack Sizes: 10 mM * 1 mL; 5 mg. Product ID: HY-18257. | |
| Rolofylline | Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 ( CYP 450 ) [1]. Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KW-3902. CAS No. 136199-02-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10965. | |
| Roluperidone | Roluperidone (CYR-101) is a novel cyclic amide derivative that has high equipotent affinities for 5-HT 2A and sigma-2 receptors ( K i of 7.53 nM and 8.19 nM for 5-HT 2A and sigma-2, respectively). Uses: Scientific research. Group: Signaling pathways. Alternative Names: CYR-101; MIN-101; MT-210. CAS No. 359625-79-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19469. | |
| Romaciclib monohydrochloride | SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50s of 4.4 nM and 10.4 nM, respectively, with a Kd of 3 nM for CDK8. SEL120-34A monohydrochloride weakly inhibits CDK9 (calculated IC50=1070 nM), but shows no obvious activity against CDK1, 2, 4, 6, 5, 7. SEL120-34A monohydrochloride inhibits phosphorylation of STAT1 S727 and STAT5 S726[1]. Has anti-tumor activity[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SEL120-34A monohydrochloride. CAS No. 2443816-41-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111388A. | |
| Romidepsin | Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC 50 s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively [1]. Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FK 228; FR 901228; NSC 630176. CAS No. 128517-07-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15149. | |
| Romifidine | Romifidine is an α 2 adrenergic receptor agonist. Romifidine shows sedation effects in vivo [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 65896-16-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-119456. | |
| Romiplostim | Romiplostim is a fusion protein analogue of TPO (thrombopoietin protein) Fc peptide, and is a peptide-body molecule. Romiplostim increases platelet production by activating the thrombopoietin receptor TPO receptor. The peptidosome molecule has two identical single-stranded subunits, each consisting of 269 amino acid residues [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2626841-92-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990685. | |
| Romlusevimab | Romlusevimab (BRII-198) is a neutralizing recombinant human IgG1 monoclonal antibody against the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BRII-198. CAS No. 2509447-08-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99889. | |
| Romosozumab | Romosozumab is a humanized monoclonal anti-sclerostin antibody , it promotes bone formation and inhibits bone resorption by inhibiting sclerostin. Romosozumab can be used for the research of osteoporosis [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 909395-70-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9982. | |
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