MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| SAE-14 | SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC-induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GPR183 antagonist-1. CAS No. 1241280-25-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147222. |  |
| Safimaltib | Safimaltib (JNJ-67856633) is an orally active, first-in-class, potent, selective and allosteric MALT1 protease inhibitor. Safimaltib in some cases lead to tumor stasis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ-67856633. CAS No. 2230273-76-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139399. | |
| Safinamide | Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 μM) over MAO-A (IC50=580 μM)[1]. Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 μM) than at resting (IC50=262 μM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al[2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FCE 26743; EMD 1195686. CAS No. 133865-89-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-70057. | |
| Safinamide mesylate | Safinamide (FCE 26743; EMD 1195686) mesylate is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 μM) over MAO-A (IC50=580 nM)[1]. Safinamide mesylate also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8?μM) than at resting (IC50=262?μM) potentials. Safinamide mesylate has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke et.al[2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FCE 26743 mesylate; EMD 1195686 mesylate. CAS No. 202825-46-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-70057A. | |
| SAFit2 | SAFit2, a chemical probe, is a highly potent, highly selective FK506-binding protein 51 (FKBP51) inhibitor with a Ki of 6 nM and also enhances AKT2-AS160 binding[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1643125-33-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102080. | |
| Saflufenacil | Saflufenacil is a herbicide of the pyrimidinedione chemical class preplant burndown and selective preemergence dicot weed control in multiple crops, including corn. Saflufenacil is a potent inhibitor of protoporphyrinogen IX oxidase (PPO)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 372137-35-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118923. | |
| Safranal | Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinsons disease research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 116-26-7. Pack Sizes: 500 mg. Product ID: HY-N7560. | |
| Safusidenib | Safusidenib (AB-291; DS-1001) is an orally bioavailable, selective mutant IDH1 inhibitor. Safusidenib strongly inhibits mutant IDH1 but not wild-type IDH1. Safusidenib impairs tumor activity in chondrosarcoma[1]. Safusidenib exhibits activity against IDH1R132H, and IDH1R132C with IC50s of 15, and 130 nM in assays without any preincubation, respectively[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AB-291; DS-1001. CAS No. 1898206-17-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-145594. | |
| SAG | SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 912545-86-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12848. | |
| SAG-524 | SAG-524 is a potent oral small molecule HBV viral replication inhibitor. SAG-524 decreased HBV-DNA and HbsAg levels in supernatant of HepG2.2.15 cells, IC50 0.92 and 1.4 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2246696-89-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-157993. | |
| SAG dihydrochloride | SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2702366-44-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12848C. | |
| SAG hydrochloride | SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2095432-58-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12848B. | |
| SAG (Standard) | SAG (Standard) is the analytical standard of SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 912545-86-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-12848R. | |
| SAH | SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SAH (S-Adenosylhomocysteine). CAS No. 979-92-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19528. | |
| SAHA-BPyne | SAHA-BPyne is an activity-based protein profiling (ABPP) probe for detecting HDAC activity, which covalently labels the proximal proteins through a photoactivation. SAHA-BPyne inhibits HDAC activity in HeLa nuclear lysate with an IC50 of less than 5 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 930772-88-6. Pack Sizes: 100 μg (1.05 mM * 200 μL in Methanol); 1 mg (1.05 mM * 2 mL in Methanol). Product ID: HY-126943. | |
| SAHA chloroalkane T1 | SAHA chloroalkane T1 is a chloroalkane capture tag by tethering Vorinostat (SAHA) and a chloroalkane tag T1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1613617-05-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111595. | |
| SAHM1 | SAHM1, a peptide mimetic of a dominant negative form of mastermind-like (MAML), inhibits canonical Notch transcription complex formation. SAHM1 can be used for the research of allergic airway inflammation in mice[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2050906-89-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2203. | |
| SAH (Standard) | SAH (Standard) is the analytical standard of SAH. This product is intended for research and analytical applications. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SAH (S-Adenosylhomocysteine) (Standard). CAS No. 979-92-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19528R. | |
| SAICAR | SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC50 of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3031-95-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 μg; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-126585. | |
| Saikosaponin A | Saikosaponin A is the main active ingredient in Bupleurum chinense, which can regulate lipid metabolism and promote cholesterol efflux in early atherosclerosis. In addition, Saikosaponin A may also serve as a potential peroxisome proliferator-activated receptor γ (PPAR-γ) agonist, significantly promoting the expression of PPAR-γ. Saikosaponin A can be used in the study of hyperlipidemic pancreatitis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 20736-09-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0246. | |
| Saikosaponin C | Saikosaponin C is an orally active MMP-2 inducer. Saikosaponin C induces the survival, growth, migration and capillary tube formation of endothelial cells. Saikosaponin C inhibits the early stage of hepatitis C virus infection. Saikosaponin C can be used in research related to ischemic tissue diseases, chronic kidney diseases and hepatitis C virus infection[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 20736-08-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N0249. | |
| SAK3 | SAK3 is a potent T-type voltage-gated Ca2+ channels (T-VGCCs) enhancer. SAK3 enhances Cav3.1 and Cav3.3 T-type Ca2+ channel currents. Acute SAK3 administration improves memory deficits in olfactory-bulbectomized mice[1]. SAK3 inhibits amyloid β plaque formation in APP-KI mice by activating the proteasome activity[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1256269-87-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-120597. | |
| Sakuranetin | Sakuranetin is a cherry flavonoid phytoalexin, shows strong antifungal activity[1]. Sakuranetin has anti-inflammatory and antioxidative activities. Sakuranetin ameliorates LPS-induced acute lung injury[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2957-21-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N3006. | |
| Sal003 | Sal003 is a potent, specific and cell-permeable inhibitor of the eukaryotic translation initiation factor 2α (eIF2α) phosphatase. Sal003 is a derivative of salubrinal[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1164470-53-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15969. | |
| Salannin | Salannin, a limonoid bitter principle of the seed oil of Azadirachta indica, shows antiulcer and spermicidal activities. Salannin displays antibacterial activity towards both Gram-positive and Gram-negative bacteria[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 992-20-1. Pack Sizes: 1 mg. Product ID: HY-123026. | |
| Salbutamol | Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Albuterol; AH-3365. CAS No. 18559-94-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-B1037. | |
| Salbutamol hemisulfate | Salbutamol (Albuterol) hemisulfate is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol hemisulfate promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol hemisulfate can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Albuterol hemisulfate; AH-3365 hemisulfate. CAS No. 51022-70-9. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg. Product ID: HY-B0436. | |
| Salcaprozate sodium | Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SNAC. CAS No. 203787-91-1. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 500 mg; 1 g. Product ID: HY-114299. | |
| Salcaprozate sodium (Standard) | Salcaprozate (sodium) (Standard) is the analytical standard of Salcaprozate (sodium). This product is intended for research and analytical applications. Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SNAC (Standard). CAS No. 203787-91-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-114299R. | |
| Salermide | Salermide is an inhibitor of Sirt1 and Sirt2; can cause strong cancer-specific apoptotic cell death. Uses: Scientific research. Category: Signaling pathways. CAS No. 1105698-15-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101073. | |
| Salicylamide | Salicylamide is an inhibitor of microsomal UDP-glucuronosyltransferase. Salicylamide is an analgesic and anti-pyretic agent. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Hydroxybenzamide. CAS No. 65-45-2. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-B0811. | |
| Salicyl-AMS | Salicyl-AMS is a mycobactin biosynthesis inhibitor which can also inhibit M. tuberculosis growth in vitro under iron-limited conditions. Uses: Scientific research. Category: Signaling pathways. CAS No. 863238-55-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108941. | |
| Salicylic acid | Salicylic acid (2-Hydroxybenzoic acid) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation. Salicylic acid has blood-brain barrier permeability[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Hydroxybenzoic acid. CAS No. 69-72-7. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 10 g; 50 g. Product ID: HY-B0167. | |
| Salicylic acid 2-O-β-D-glucoside | Salicylic acid 2-O-β-D-glucoside (SA-2-O-β-D-glucoside) is the glucose-conjugated product of Salicylic Acid (HY-B0167) in plants. Salicylic acid 2-O-β-D-glucoside belongs to an inactive storage form. Salicylic acid 2-O-β-D-glucoside can be used in studies of plant pathogen infection[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SA-2-O-β-D-glucoside. CAS No. 10366-91-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W585952. | |
| Salicylic acid-d6 | Salicylic acid-d6 is a deuterium labeled Salicylic acid (HY-B0167). Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Hydroxybenzoic acid-d6. CAS No. 285979-87-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-B0167S. | |
| Salidroside | Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Rhodioloside. CAS No. 10338-51-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-N0109. | |
| Salidroside (Standard) | Salidroside (Standard) is the analytical standard of Salidroside. This product is intended for research and analytical applications. Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Rhodioloside (Standard). CAS No. 10338-51-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0109R. | |
| Salinomycin | Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin shows selective activity against human cancer stem cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Procoxacin. CAS No. 53003-10-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15597. | |
| Salinomycin sodium salt | Salinomycin sodium salt (Salinomycin sodium), an antibiotic potassium ionophore, is a potent inhibitor of Wnt/β-catenin signaling. Salinomycin sodium salt acts on the Wnt/Fzd/LRP complex, blocks Wnt-induced LRP6 phosphorylation, and causes degradation of the LRP6 protein. Salinomycin sodium salt shows selective activity against human cancer stem cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Salinomycin sodium; Sodium salinomycin. CAS No. 55721-31-8. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-17439. | |
| Salipurpin | Salipurpin (Apigenin 5-glucoside) is a flavonoid compound isolated from the branches and leaves of Cephalotaxus fortunei, which has certain anti-inflammatory activity[1]. Uses: Scientific research. Category: Natural products. Alternative Names: Apigenin 5-glucoside. CAS No. 28757-27-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N2883. | |
| Salirasib | Salirasib is a Ras inhibitor that inhibits specifically both oncogenically activated Ras and growth factor receptor-mediated Ras activation, resulting in the inhibition of Ras-dependent tumor growth. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-Farnesylthiosalicylic acid; Farnesyl Thiosalicylic Acid; FTS. CAS No. 162520-00-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14754. | |
| S-Allyl-L-cysteine | S-Allyl-L-cysteine, one of the organosulfur compounds found in AGE, possess various biological effects including neurotrophic activity, anti-cancer activity, anti-inflammatory activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 21593-77-1. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W013573. | |
| S-Allylmercaptocysteine | S-allylmercaptocysteine, an organic sulfur compound extracted from garlic, has anti-inflammatory and anti-oxidative effects for various pulmonary diseases. S-allylmercaptocysteine achieves its anti-cancer effect through a variety of pathways such as inducing the apoptosis of cancer cells through the TGF-β signaling pathway, or reducing the NF-κB activity and up-regulating Nrf2 to achieve the effects of anti-inflammation and anti-oxidation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2281-22-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145532. | |
| Salmeterol | Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GR33343X. CAS No. 89365-50-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14302. | |
| Salmeterol xinafoate | Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GR 33343X xinafoate. CAS No. 94749-08-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17453. | |
| Salsalate | Salsalate is a potent antirheumatic drug with oral activity that reduces irritation during gastric absorption and avoids direct inhibition of cyclooxygenase. Salsalate not only has significant anti-inflammatory effects, but also reduces blood sugar levels, improves insulin resistance, and reduces the expression of cytokines. Salsalate can protect mice from metabolic disorders caused by high-fat diet and effectively improve the symptoms of type 2 diabetes, atherosclerosis and non-alcoholic steatohepatitis[1][2 ][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Salicylsalicylic acid; Disalicylic acid. CAS No. 552-94-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B1245. | |
| Saluamine | Saluamine is an important N-dealkylated metabolite of Furosemide (HY-B0135) that is produced by microbial transformation and bile metabolism. Saluamine is a contaminant[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3086-91-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-W278566. | |
| Salubrinal | Salubrinal is a cell-permeable and selective inhibitor of eIF2α dephosphorylation[1]. Salubrinal acts as a dual-specificity phosphatase 2 (Dusp2) inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis[2]. Salubrinal has antiviral activity against HSV-1 and inhibits dephosphorylation of eIF2α mediated by the HSV-1 protein ICP34.5[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 405060-95-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-15486. | |
| Salviaflaside | Salviaflaside is a main bioactive component of Spica Prunellae[1]. Uses: Scientific research. Category: Natural products. CAS No. 178895-25-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N3010. | |
| Salvianolic acid A | Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation. Uses: Scientific research. Category: Signaling pathways. CAS No. 96574-01-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N0318. | |
| Salvianolic acid B | Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lithospermic acid B. CAS No. 121521-90-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N1362. | |
| Salvianolic acid C | Salvianolic acid C is a noncompetitive Cytochrome P4502C8 (CYP2C8) inhibitor and a moderate mixed inhibitor of Cytochrome P45022J2 (CYP2J2), with Kis of 4.82 μM and 5.75 μM for CYP2C8 and CYP2J2, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 115841-09-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0319. | |
| Salvinorin B | Salvinorin B is a selective and brain-penetrant kappa opioid receptor (KOPr) agonist with an EC50 of 248 nM and Ki of 2.95 μM. Salvinorin B activates downstream signaling pathways by binding to KOPr, inhibits pain transmission and reduces inflammatory response. Salvinorin B can be used for the researches of inflammation, immunology and neurological disease, such as neuropathic pain, multiple sclerosis and anxiety[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 92545-30-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-110252. | |
| Samalizumab | Samalizumab (ALXN 6000) is a humanized monoclonal antibody that specifically binds to CD200 and blocks its ligation to the CD200 receptor (CD200R). Samalizumab can be used for multiple myeloma and B-cell chronic lymphocytic leukemia research[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: ALXN 6000. CAS No. 1073059-33-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99400. | |
| Samatasvir | Samatasvir (IDX71) is a potent, orally active NS5A inhibitor of HCV replication. Samatasvir is effective and selective against infectious HCV and replicons, with EC50s falling within a tight range of 2 to 24 pM in genotype 1 through 5 replicons[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IDX719; IDX18719. CAS No. 1312547-19-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16784. | |
| SAMβA | SAMβA is conjugated to the cell permeable peptide TAT47-57. SAMβA, a rationally designed selective antagonist of Mfn1-βIIPKC association. SAMβA is a selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2429946-75-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P3429. | |
| Samelisant | Samelisant (SUVN-G3031) is a potent and selective histamine H3 receptor (H3R) inverse agonist with good brain penetration and oral bioavailability. Samelisant has a similar binding affinity towards human (hH3R; Ki=8.7 nM) and rat (rH3R;Ki=9.8 nM) H3R indicating no inter-species differences. Samelisant can be used for the research of sleep-related disorders[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SUVN-G3031. CAS No. 1394808-20-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120124. | |
| Samidorphan | Samidorphan (ALKS-33) is an orally active opioid system modulator that has a high affinity for binding with μ?opioid, κ?opioid, and δ?opioid receptors. Samidorphan acts as an antagonist at μ?opioid receptors and acts as a partial agonist at k-opioid and δ?opioid receptors. Samidorphan primarily acts as an opioid receptor antagonist in vivo. Samidorphan can improve the behavior of depressed animals[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALKS-33; RDC-0313. CAS No. 852626-89-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123689. | |
| Samotolisib | Samotolisib (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, DNA-PK and mTOR, respectively. Samotolisib potently inhibits mTORC1/2 at low nanomolar concentrations[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY3023414. CAS No. 1386874-06-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12513. | |
| (S)-AMPA | (S)-AMPA (L-AMPA), an active S-enantiomer of AMPA, is a potent and selective AMPA receptor agonist[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L-AMPA. CAS No. 83643-88-3. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100815A. | |
| Samrotamab | Samrotamab (PR-1498487) is a humanized IgG1-κ chimeric antibody targeting LRRC15. Samrotamab markedly reduces bladder cancer cells viability and inhibits clonogenic growth, migratory and invasive capabilities. Samrotamab significantly increases LRRC15 mRNA level while suppressing SCG5 mRNA expression. Samrotamab can be used for synthesis of ADC ABBV-085[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PR-1498487. CAS No. 2052591-32-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99899. | |
| Samuraciclib | Samuraciclib (CT7001) is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC50 of 41 nM. Samuraciclib displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2 (IC50 of 578 nM), CDK5 and CDK9, respectively. Samuraciclib inhibits the growth of breast cancer cell lines with GI50 values between 0.2-0.3 μM. Samuraciclib has anti-tumor effects[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CT7001; ICEC0942. CAS No. 1805833-75-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103712. | |
| Samuraciclib hydrochloride | Samuraciclib hydrochloride (CT7001 hydrochloride) is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC50 of 41 nM. Samuraciclib hydrochloride displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2 (IC50 of 578 nM), CDK5 and CDK9, respectively. Samuraciclib hydrochloride inhibits the growth of breast cancer cell lines with GI50 values between 0.2-0.3 μM. Samuraciclib hydrochloride has anti-tumor effects[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CT7001 hydrochloride; ICEC0942 hydrochloride. CAS No. 1805789-54-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103712A. | |
| Sandoz 58-035 | Sandoz 58-035 is a selective acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. Sandoz 58-035 inhibits this enzyme in intact cells and isolated microsomal fractions. Sandoz 58-035 blocks the esterification of exogenous vesicle-derived cholesterol and the incorporation of oleic acid into cellular cholesterol esters, reducing the formation and accumulation of cholesterol esters. Sandoz 58-035 causes a slight increase in cellular free cholesterol, and at high concentrations, it also causes a slight reduction in overall cellular protein synthesis. Sandoz 58-035 can be used in studies related to cellular cholesterol regulation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 78934-83-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-112487. | |
| Sanggenon C | Sanggenon C, a flavonoid, exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits mitochondrial fission to induce apoptosis by blocking the ERK signaling pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and TNF-α-stimulated cell adhesion and VCAM-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory and antitumor activities[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 80651-76-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0617. | |
| Sangivamycin | Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 65346; BA-90912. CAS No. 18417-89-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-118384. | |
| Sanguinarine chloride | Sanguinarine (Sanguinarin) chloride, a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride. CAS No. 5578-73-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 100 mg. Product ID: HY-N0052A. | |
| SANT-1 | SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 304909-07-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100224. | |
| Santacruzamate A | Santacruzamate A (CAY-10683, STA) is a potent and selective HDAC2 inhibitor with an IC50 of 119 pM. STA also exerts neuroprotective property against amyloid-β protein fragment 25-35. STA can be used for cancer and neurological disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CAY-10683. CAS No. 1477949-42-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0931. | |
| Santalene | Santalene is a bicyclic sesquiterpene and a major component of sandalwood oil found in the heartwood of Santalum album. Santalene exhibits antibacterial, antioxidant and antitumor pharmacological activities[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: α-Santalene. CAS No. 512-61-8. Pack Sizes: 1 mg. Product ID: HY-127033. | |
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