MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Seclidemstat | Seclidemstat is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat can be used for the research of Ewing Sarcoma[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SP-2577. CAS No. 1423715-37-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103713. |  |
| Seclidemstat mesylate | Seclidemstat (SP-2577) mesylate is a potent noncompetitive and reversible KDM1A (LSD1) inhibitor (Ki=31 nM, IC50=13 nM). Seclidemstat mesylate promotes antitumor immunity in switch/sucrose nonfermentable (SWI/SNF) complex mutated ovarian cancer, as well as inhibit virus production, viral DNA replication, and late gene expression. Seclidemstat mesylate can be used for the research of Ewing Sarcoma[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SP-2577 mesylate. CAS No. 2044953-70-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103713A. | |
| Secnidazole (Standard) | Secnidazole (Standard) is the analytical standard of Secnidazole. This product is intended for research and analytical applications. Secnidazole (RP-14539) is an orally active azole antibiotic and a imidazole mitigator of Serratia marcescens virulence. Secnidazole, as an analog of acylhomoserine lactones, effectively inhibits QS resulting in the attenuation of Pseudomonas aeruginosa pathogenesis. Secnidazole has antimicrobial activity against many anaerobic Gram-negative and Gram-positive bacterial species in vitro. Secnidazole can be used for the research of various diseases, such as amoebiasis and giardiasis, and bacterial vaginitis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RP-14539 (Standard); PM-185184 (Standard). CAS No. 3366-95-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1118R. | |
| Seco-DUBA | Seco-DUBA hydrochloride is a DNA-targeting cytotoxic agent. Seco-DUBA hydrochloride binds to the minor groove of A-T-rich DNA regions, alkylates the adenine N3 residue, and undergoes spontaneous spirocyclization to generate active DUBA (HY-160969). Seco-DUBA hydrochloride exerts cytotoxic activity against human cancer cells. The reduced hydrophobicity of Seco-DUBA hydrochloride supports the development of antibody-drug conjugates[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1227961-59-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-132180A. | |
| Secoisolariciresinol | Secoisolariciresinol ((-)-Secoisolariciresinol) is a plant lignan and a precursor of enterolignans. Secoisolariciresinol can be converted into enterodiol and enterolactone by intestinal microflora. Secoisolariciresinol may reduce the risk of cancer and cardiovascular diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Secoisolariciresinol. CAS No. 29388-59-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N6071. | |
| Seco Rapamycin sodium salt | Seco Rapamycin sodium salt is the ring-opened product of Rapamycin. Seco-rapamycin is reported not to affect the mTOR function. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Secorapamycin A monosodium. CAS No. 148554-65-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19555A. | |
| Secretin (5-27) (porcine) | Secretin (5-27, porcine) (SQ 19301) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SQ 19301. CAS No. 19665-15-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4913. | |
| Secretin (swine) | Secretin (swine), a neuroendocrine hormone, is the first hormone to be identifie and is secreted by S cells that are localized primarily in the mucosa of the duodenum. Secretin also is a 27-amino acid peptide, which acts on secretin receptors. Secretin is expressed by cells in all mature enteroendocrine cell subsets and can be prompted by fatty acids. Secretin stimulates the secretion of pancreatic water and bicarbonate. Secretin exerts various effects in organs, can be used for the research of digestive system, central nervous system and energy metabolism[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 17034-35-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-109538. | |
| Secretoneurin, rat | Secretoneurin, rat, a 33-amino acid polypeptide, is generated by proteolytic processing of secretogranin II (SgII). Secretoneurin, rat induces dopamine release in the rat striatum in vivo and in vitro, and it exerts a very strong chemotactic effect on monocytes and eosinophils but not on granulocytes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 149146-12-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1764. | |
| Secukinumab | Secukinumab (AIN457) is a high affinity, human monoclonal antibody targeted against interleukin (IL)-17A. Secukinumab is the first-in-class anti-IL-17 agent used for the research of plaque psoriasis, ankylosing spondylitis and psoriatic arthritis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AIN457. CAS No. 1229022-83-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P9927. | |
| Secukinumab (Anti-Human IL-17A) | Secukinumab (Anti-Human IL-17A) is a fully human anti-interleukin-17A monoclonal antibody. Anti-Human IL-17A can be used for research in psoriasis pathogenesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1229022-83-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P9927A. | |
| (-)-Securinine | (-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist. Uses: Scientific research. Category: Signaling pathways. CAS No. 5610-40-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-N2079. | |
| Secutrelvir | Secutrelvir is an oral SARS-CoV-2 3C-like protease (3CLpro) inhibitor and antiviral agent, with IC50 values of 0.655 nM and 0.697 nM against SARS-CoV-2 3CLpro, respectively. Secutrelvir forms a reversible covalent bond with the catalytic cysteine C145 of SARS-CoV-2 3CLpro, thereby inhibiting viral replication. Secutrelvir exhibits activity against multiple SARS-CoV-2 variants and can be used in research related to coronavirus disease 2019 (COVID-19)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-892216. CAS No. 2996148-73-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172437. | |
| Sedanolide | Sedanolide, a natural compound occurring in edible umbelliferous plants, possesses anti-inflammatory and antioxidant activities[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6415-59-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N2114. | |
| (S)-Edelfosine | (S)-Edelfosine ((S)-ET-18-OCH3) is the (S)-enantiomer of Edelfosine (ET-18-OCH3) (HY-108610C). Edelfosine is a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 Death receptor[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-ET-18-OCH3. CAS No. 83542-43-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-108610C. | |
| SEL120-34A | SEL120-34A is a potent, selective, orally available, ATP-competitive CDK8 inhibitor, with IC50s of 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC, respectively, with antitumor activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 1609522-33-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111388. | |
| SEL24-B489 | SEL24-B489 is a potent, type I, orally active, dual PIM and FLT3-ITD inhibitor, with Kd values of 2 nM for PIM1, 2 nM for PIM2 and 3 nM for PIM3, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1616359-00-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-120758. | |
| Selachyl alcohol | Selachyl alcohol is an orally active antihypertensive agent. Selachyl alcohol has similar activities with antihypertensive neutral renomedullary lipid (ANRL). Selachyl alcohol is an alkylglycerol compound in shark liver oil mixture with properties that reduce lung metastasis. Selachyl alcohol can be used for cardiovascular disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 593-31-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152899. | |
| Seladelpar | Seladelpar (MBX-8025) is an orally active, potent and specific PPARδ agonist with an EC50 of 2 nM. Seladelpar shows more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively. Seladelpar can be used for the study of primary biliary cholangitis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MBX-8025; RWJ-800025. CAS No. 851528-79-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19522. | |
| Seladelpar sodium | Seladelpar (MBX-8025) sodium salt is an orally active, potent and specific PPARδ agonist with an EC50 of 2 nM. Seladelpar sodium salt shows more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively. Seladelpar sodium salt hydrochloride can be used for the study of primary biliary cholangitis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MBX-8025 sodium; RWJ-800025 sodium. CAS No. 3026272-26-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19522A. | |
| Selamectin | Selamectin, a semi-synthetic macrocyclic lactone, is a potent parasiticide and anthelminthic. Selamectin activates glutamate-gated chloride channels in neurons and pharyngeal muscles to prevent heartworm, Lymphatic filariae, and nematode infection. Selamectin is also a potent P-glycoprotein substrate and a P-glycoprotein inhibitor with an IC50 of 120 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 220119-17-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107212. | |
| Selank | Selank (Selanc; TP-7) is a GABAA receptor modulator with anxiolytic activity. Selank allosterically modulates the specific binding of GABA to GABAA receptors and alters the affinity of endogenous ligands for these receptors. Selank reduces elevated anxiety levels, attenuates stress-induced exacerbation of anxiety, and produces a synergistic anxiolytic effect with diazepam. Selank can be used in the research of anxiety disorders[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Selanc; TP-7. CAS No. 129954-34-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-105042. | |
| Selatinib | Selatinib is a reversible and orally active dual EGFR and ErbB2 inhibitor with IC50s of 13 nM and 22.5 nM, respectively. Selatinib has anticancer effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1275595-86-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116437. | |
| Selcodebart | Selcodebart (Anti-RGMC/HFE2 Antibody (DISC-0974)) is a CHO-expressed human antibody that targets RGMC/HFE2. Selcodebart features a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.66 kDa. For the isotype control of Selcodebart, please refer to Human IgG1 kappa, Isotype Control (HY-P99001). Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: Anti-RGMC/HFE2 Antibody (DISC-0974); DISC-0974. CAS No. 3038196-66-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P990498. | |
| Seldegamadlin | Seldegamadlin (KT-253) is a selective p53 stabilizer and a MDM2 PROTAC degrader (DC50 = 0.4 nM). Seldegamadlin inhibits the proliferation of cancer cell RS4;11 with an IC50 of 0.3 nM, arrests the cell cycle at G2/M phase, and induces apoptosis. Seldegamadlin upregulates p53 activity and overcomes the p53-MDM2 feedback loop. Seldegamadlin can be used for the study of hematologic and solid tumors, such as acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). (Pink: ligand for target protein MDM2 ligand 4 (HY-170452); Black: linker (HY-W001478); Blue: ligand for E3 ligase cereblon (HY-163927))[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KT-253. CAS No. 2713618-08-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-170451. | |
| Selegiline hydrochloride | Selegiline (Deprenyl) hydrochloride is a potent, selective and irreversible inhibitor of MAO-B, with an IC50 of 51 nM. Selegiline hydrochloride exhibits 450-flod selectivity for MAO-B over MAO-A (IC50=23 μM). Selegiline hydrochloride can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Deprenyl hydrochloride; (-)-Selegiline hydrochloride; (-)-Deprenyl hydrochloride. CAS No. 14611-52-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg. Product ID: HY-14199. | |
| Selenocystamine dihydrochloride | Selenocystamine dihydrochloride is a selenocysteine derivative that can be used in the synthesis of other active compounds. Selenocystamine dihydrochloride can also induce the aggregation of amphiphilic p-sulfonatocalixarene to form supramolecular nanoparticles[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3542-13-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g. Product ID: HY-W105804. | |
| Selenocystine | Selenocystine is a broad-spectrum anti-cancer agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2897-21-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-113064. | |
| Selenomethionine | Selenomethionine is a naturally occurring amino acid containing selenium that has oral activity and is a common natural food source. Selenomethionine has antitumor activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Seleno-DL-methionine; DL-Selenomethionine. CAS No. 1464-42-2. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-B1000. | |
| Selexipag | Selexipag (NS-304) is an orally available and potent agonist for the Prostacyclin (PGI2) receptor (IP receptor). Uses: Scientific research. Category: Signaling pathways. Alternative Names: NS-304; ACT-293987. CAS No. 475086-01-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14870. | |
| Selgantolimod | Selgantolimod (GS-9688) is an orally active, potent and selective toll-like receptor 8 (TLR8) agonist for the treatment of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infection[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GS-9688. CAS No. 2004677-13-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-109137. | |
| Selinexor | Selinexor (KPT-330) is an analog of KPT-185 (HY-15611). Selinexor is an orally active, selective CRM1 inhibitor that inhibits tumor growth by inducing PANoptosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KPT-330. CAS No. 1393477-72-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17536. | |
| Selisistat | Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in Drosophila melanogaster) inhibitor with an IC50 of 123 nM for SirT1. Selisistat alleviates pathology in multiple animal and cell models of Huntington's disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EX-527. CAS No. 49843-98-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15452. | |
| Se litrectinib | Selitrectinib (LOXO-195) is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LOXO-195. CAS No. 2097002-61-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101977. | |
| Selnoflast | Selnoflast (RO7486967), formerly somalix/RG6418/IZD334, is an orally active, potent, selective and reversible small molecule NLRP3 inflammasome inhibitor. Selnoflast is a potent inhibitor of IL-1β release stimulated by NLRP3 activation in human Alzheimer's disease (AD) monocyte-derived macrophages. Selnoflast is promising for research of AD and systemic inflammatory diseases, such as ulcerative colitis and chronic obstructive pulmonary disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Somalix; RO-7486967; IZD334. CAS No. 2260969-36-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-132831. | |
| Selonsertib | Selonsertib (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GS-4997. CAS No. 1448428-04-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-18938. | |
| Selpercatinib | Selpercatinib (LOXO-292) is a potent, selective RET kinase inhibitor with IC50 values of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively. Selpercatinib has anticancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LOXO-292. CAS No. 2152628-33-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114370. | |
| Seltorexant hydrochloride | Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ-42847922 hydrochloride. CAS No. 1293284-49-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109012A. | |
| Selumetinib | Selumetinib (AZD6244) is selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. Selumetinib (AZD6244) inhibits ERK1/2 phosphorylation. Selumetinib can penetrate the blood brain barrier (BBB)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD6244; ARRY-142886. CAS No. 606143-52-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-50706. | |
| Selumetinib sulfate | Selumetinib (AZD6244) sulfate is selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. Selumetinib (AZD6244) sulfate inhibits ERK1/2 phosphorylation. Selumetinib sulfate can penetrate the blood brain barrier (BBB)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD6244 sulfate; ARRY-142886 sulfate. CAS No. 943332-08-9. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-50706A. | |
| Selurampanel | Selurampanel (BGG 492) is an orally active and competitive AMPA receptor antagonist with an IC50 of 190 nM. Selurampanel has reasonable blood-brain barrier penetration. Selurampanel can be used for epilepsy research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BGG 492. CAS No. 912574-69-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-105860. | |
| Selvigaltin | Selvigaltin (GB1211) is an orally active galectin-3 small molecule inhibitor with an IC50 value of 12 nM in rabbits, showing anti-tumor activity. Selvigaltin decreases galectin-3 levels in the liver and reduces biomarkers of liver function (AST, ALT, bilirubin), inflammation (cells foci) and fibrosis (PSR, SHG), as well as decreasing the mRNA and protein expression of several key inflammation and fibrosis biomarkers (IL6, TGFβ3, SNAI2, collagen). Selvigaltin restores T-cell activity and induces less tumors and metastasis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GB1211. CAS No. 1978336-95-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147041. | |
| Semagacestat | Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid (Aβ42), Aβ38 and Aβ40 with IC50s of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC50 of 14.1 nM. Semagacestat can be used for the research of alzheimer's disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY450139. CAS No. 425386-60-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-10009. | |
| Semaglutide | Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 910463-68-2. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-114118. | |
| Semaglutide acetate | Semaglutide acetate is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide acetate promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide acetate also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide acetate has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide acetate can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1997361-85-9. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-114118B. | |
| Semaglutide (crude) | Semaglutide (crude) is the crude form of Semaglutide (HY-114118). Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances Autophagy, inhibits oxidative stress and Apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 910463-68-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114118CP. | |
| Semaglutide Main Chain (9-37) | Semaglutide Main Chain (9-37) is a peptide starting material in the synthesis of semaglutide (HY-114118)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1169630-82-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-Z11724. | |
| Semapimod tetrahydrochloride | Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC50?0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CNI-1493; CPSI-2364 tetrahydrochloride. CAS No. 164301-51-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15509A. | |
| Semax | Semax is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu2+. Semax is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax has immunomodulatory, nootropic and neuroprotective activities. Semax can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 80714-61-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1146. | |
| Semax acetate | Semax acetate is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu2+. Semax acetate is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax acetate has immunomodulatory, nootropic and neuroprotective activities. Semax acetate can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2828433-33-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1146A. | |
| Semaxinib | Semaxinib (SU5416) is a potent and selective inhibitor of VEGFR (Flk-1/KDR) with an IC50 of 1.23 μM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SU5416. CAS No. 204005-46-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-10374. | |
| Se-Methylselenocysteine (Standard) | Risedronic acid (Standard) is the analytical standard of Risedronic acid. This product is intended for research and analytical applications. 0. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Methylselenocysteine (Standard); Se-Methylseleno-L-cysteine (Standard). CAS No. 26046-90-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114245R. | |
| Semicarbazide-13C,15N2 hydrochloride | Semicarbazide-13C,15N2 hydrochloride is 15N and 13C labeled Semicarbazide. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Aminourea-13C,15N2 hydrochloride; Hydrazinecarboxamide-13C,15N2 hydrochloride. CAS No. 1173020-16-0. Pack Sizes: 10 mg. Product ID: HY-W067028S. | |
| Semorinemab | Semorinemab (RG 6100) is an anti-Tau humanized IgG4 monoclonal antibody, targets the N-terminal portion of the Tau protein (amino acid residues 6-23). Semorinemab binds with human Tau with a Kd value of 3.8 nM. Semorinemab can be used for the research of Alzheimer's Disease[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RG 6100; RO7105705; MTAU-9937A. CAS No. 2159141-27-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99399. | |
| Semzuvolimab | Semzuvolimab is a human IgG1κ antibody, targeting to p55, T cell surface antigen T4/Leu-3 (CD4). Human CD4 antibodies can neutralize HIV infection and have the potential to inhibit HAART stable HIV infection[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UB421. CAS No. 2409099-32-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9998. | |
| SEN177 | SEN177 is an orally effect glutamine cyclase (QC) inhibitor. The Ki of SEN177 for human glutamine cyclase (hQC) is 20 nM, and the IC50 is 13 nM. SEN177 interferes with the interaction between CD47 and SIRRPα, and has anti-tumor activity. SEN177 reduces aggregation and apoptosis caused by HTT mutation in Huntington model, and can be used in the study of neurodegenerative diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2117405-13-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-136780. | |
| Senaparib | Senaparib (IMP4297) is a highly potent, selective and orally active PARP1/2 inhibitor. Senaparib (IMP4297) exhibits strong antitumor activity in animal models[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IMP4297; JS109. CAS No. 1401682-78-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137450. | |
| Senecionine | Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH)[1][2][3]. Uses: Scientific research. Category: Natural products. Alternative Names: Senecionan-11,16-dione, 12-hydroxy-; Aureine; Senecionin. CAS No. 130-01-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2560. | |
| Senexin A | Senexin A is an inhibitor of CDK8/19 (IC50: 280 nM, CDK8) and an inhibitor downstream of p21 transcription. It only inhibits p21-induced transcription but does not inhibit other biological effects of p21. Senexin A inhibits CMV-GFP induction as well as the p21 stimulatory activity of the consensus NF-κB-dependent promoters[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1366002-50-7. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15681. | |
| Senexin B | Senexin B (SNX2-1-165; BCD-115) is a potent, highly water-soluble and bioavailable CDK8/19 inhibitor, with Kds of 140 nM for CDK8 and 80 nM for CDK19. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SNX2-1-165; BCD-115. CAS No. 1449228-40-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101800. | |
| Senexin C | Senexin C is a selective and orally active CDK8/19 inhibitor. Senexin C shows a strong tumor-enrichment pharmacokinetic (PK) profile and tumor-pharmacodynamic (PD) marker responses. Senexin C inhibits the growth of MV4-11 leukemia cells with good tolerability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2375554-02-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-143889. | |
| Senicapoc | Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM. Senicapoc blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ICA-17043. CAS No. 289656-45-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50694. | |
| Seniprutug | Seniprutug is an anti-TRBV9 human IgG1 κ monoclonal antibody[1]. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001). Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: BCD-180. CAS No. 2484772-72-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990762. | |
| Senktide | Senktide is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50=0.5-3 nM). Senktide less potently agonizes the NK1 receptor (EC50=35 μM). Senktide is promising for research of neurological disease[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 106128-89-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0187. | |
| Senkyunolide A | Senkyunolide A is a phthalide, anti-tumor cell proliferation agent with anticancer activity. Senkyunolide A protects neurons from corticosterone (HY-B1618)-induced apoptosis by decreasing protein phosphatase PP2A and α-synuclein phosphorylation and protein level. Senkyunolide A also inhibits osteoarthritis through the NLRP3 signaling pathway and suppresses the expression of CD137, a diagnostic biomarker for atherosclerosis[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 63038-10-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0743. | |
| Senkyunolide I | Senkyunolide I is an orally active, blood-brain barrier-permeable metabolite of Z-ligustilide (HY-N0401A). Senkyunolide I is isolated from Ligusticum chuanxiong. Senkyunolide I upregulates p-Erk1/2 and Nrf2/HO-1, and inhibits Caspase 3. Senkyunolide I alleviates Apoptosis. Senkyunolide I increases the pain threshold in mice and reduces acetic acid-induced writhing responses in mice. Senkyunolide I improves neurological deficits, reduces infarct volume and alleviates cerebral edema in rats with focal cerebral ischemia-reperfusion injury. Senkyunolide I protects renal function and structural integrity in a mouse model of renal ischemia-reperfusion injury. Senkyunolide I is applicable to research related to focal cerebral ischemia-reperfusion injury, migraine, and renal ischemia-reperfusion injury[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 94596-28-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0745. | |
| Sennoside A | Sennoside A is an anthraquinone glycoside found in senna (Cassia angustifolia). Sennoside A is an HIV-1 inhibitor (IC50=3.8 μM) that inhibits HIV-1 replication. Sennoside A also inhibits HIV-1 reverse transcriptase (RT)-related DNA polymerase (RDDP) and ribonuclease H (Ribonuclease H) with IC50s of 1.9 μM and 5.3 μM, respectively[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 81-27-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0365. | |
| SENP1-IN-3 | SENP1-IN-3 is a specific deSUMOylation protease 1 (SENP1) inhibitor extracted from patent CN110627860, Compound 17. SENP1-IN-3 is developed for tumor radiosensitivity enhancement[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2416910-59-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134596. | |
| Seocalcitol | Seocalcitol is a vitamin D analog, binds vitamin D receptor protein from human osteosarcoma MG-63 cells with Kd of 0.27 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EB 1089. CAS No. 134404-52-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-32341. | |
| Sepantronium bromide | Sepantronium bromide (YM-155) is a survivin inhibitor with an IC50 of 0.54 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: YM-155. CAS No. 781661-94-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10194. | |
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