MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Simeprevir | Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TMC435; TMC435350. CAS No. 923604-59-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10241. |  |
| Simethicone | Simethicone is an orally active defoamer. Simethicone reduces the surface tension of air bubbles in the gastrointestinal tract, causing them to be expelled by vomiting, exhalation or absorption into the bloodstream. Simethicone has potential applications in flatulence and colic[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 8050-81-5. Pack Sizes: 1 g; 5 g; 10 g; 50 g. Product ID: HY-109519. | |
| Simnotrelvir | SARS-CoV-2-IN-41 (compound 2) is a potent SARS-CoV-2 3CLpro inhibitor with an IC50 value of 0.022 μM. SARS-CoV-2-IN-41 shows antiviral effect[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SIM0417; SARS-CoV-2-IN-41. CAS No. 2920904-06-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-154965. | |
| Simridarlimab | Simridarlimab (IBI-322) is a bispecific antibody targeting PD-L1 and CD47. Simridarlimab attenuates CD47 activity in monovalent binding and blockes PD-L1 activity in bivalent binding. Simridarlimab selectively binds to CD47+PD-L1+ tumor cells, effectively inhibits CD47-SIRPα signal and triggered strong tumor cell phagocytosis in vitro[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IBI-322. CAS No. 2378862-90-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99903. | |
| Simtuzumab | Simtuzumab (AB 0024; GS 6624) is a monoclonal antibody directed against Lysyl oxidase like-2 (LOXL2). Simtuzumab non-competitively blocks collagen cross-linking, reduces LOXL2 protein expression and attenuates extracellular matrix changes. Simtuzumab reduces myocardial fibrosis and prevents cardiac dysfunction. Simtuzumab lowers Myh7 and Nppa gene expression, reduces contraction heterogeneity, and cuts COL1A1 deposition. Simtuzumab can be used for the research of LMNA mutation-induced dilated cardiomyopathy, idiopathic pulmonary fibrosis, and primary sclerosing cholangitis[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AB 0024; GS 6624. CAS No. 1318075-13-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99047. | |
| Simurosertib | Simurosertib (TAK-931) is an orally active, selective and ATP-competitive cell division cycle 7 (CDC7) kinase inhibitor, with an IC50 of <0.3 nM. Simurosertib has anti-cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAK-931. CAS No. 1330782-76-7. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100888. | |
| Simvastatin | Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK 733. CAS No. 79902-63-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-17502. | |
| Simvastatin hydroxy acid sodium | Simvastatin hydroxy acid (Tenivastatin) sodium is a potent HMG-CoA reductase (HMGCR) inhibitor. Simvastatin hydroxy acid sodium reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin hydroxy acid sodium can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Tenivastatin sodium; Simvastatin Impurity A sodium. CAS No. 101314-97-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-115292. | |
| Sinapaldehyde | Sinapaldehyde is a methoxyphenol and a selective COX-2 inhibitor (IC50: 47.8 μM) that can be extracted from various plants. Sinapaldehyde has antibacterial, anti-inflammatory, and antioxidant activities. Sinapaldehyde can scavenge DPPH free radicals (IC50: 172 μM). Sinapaldehyde is active against both Gram-negative and Gram-positive bacteria[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4206-58-0. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg. Product ID: HY-N1312. | |
| Sinapine | Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimers disease, ataxia, myasthenia gravis, and Parkinsons disease[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 18696-26-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N5077. | |
| Sinapine thiocyanate | Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimers disease, ataxia, myasthenia gravis, and Parkinsons disease[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7431-77-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-N0450. | |
| Sinapinic acid | Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC50 of 2.27 mM[1], and also inhibits ACE-I activity[2]. Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells[1]. Sinapinic acid shows antioxidant and antidiabetic activities[2]. Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sinapic acid. CAS No. 530-59-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g. Product ID: HY-W009732. | |
| Sinapyl alcohol | Sinapyl alcohol is an orally active anti-inflammatory and antinociceptive agent. Sinapyl alcohol reduces the expression level of inducible NO synthase and COX-2[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 537-33-7. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W109812. | |
| Sincalide | Sincalide (Cholecystokinin octapeptide, CCK-8) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide is a major bioactive segment of CCK that retains most of the biological activities of CCK. Sincalide can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide is a major bioactive segment of CCK that retains most of the biological activities of CCK[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cholecystokinin octapeptide; CCK-8; SQ19844. CAS No. 25126-32-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0093. | |
| Sinefungin | Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication[1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Adenosyl-Ornithine; A-9145; Antibiotic 32232RP. CAS No. 58944-73-3. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101938. | |
| Sinensetin | Sinensetin is a methylated flavonoid found in fruits that has strong anti-vascular and anti-inflammatory properties. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pedalitin permethyl ether. CAS No. 2306-27-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0297. | |
| Sinensetin (Standard) | Sinensetin (Standard) is the analytical standard of Sinensetin. This product is intended for research and analytical applications. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pedalitin permethyl ether (Standard). CAS No. 2306-27-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0297R. | |
| Sinigrin | Sinigrin (Allyl-glucosinolate) is an orally active glucosinolate found in cruciferous plants. Sinigrin possesses multiple activities such as anti-cancer, antibacterial, antifungal, anti-inflammatory, antioxidant, and inhibition of fat synthesis. Sinigrin can be used in the research of tumors, inflammatory, and metabolic diseases[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Allyl-glucosinolate; 2-Propenyl-glucosinolate. CAS No. 3952-98-5. Pack Sizes: 10 mM * 1 mL in Water; 10 mg; 25 mg. Product ID: HY-N0404. | |
| Sinomenine | Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation[1]. Sinomenine also is an activator of μ-opioid receptor[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 115-53-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-15122. | |
| Sinomenine hydrochloride | Sinomenine hydrochloride (Cucoline hydrochloride), an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation[1]. Sinomenine also is an activator of μ-opioid receptor[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cucoline hydrochloride. CAS No. 6080-33-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-15122A. | |
| Sintilimab | Sintilimab (IBI308) is a safe and effectivel humanized IgG4 monoclonal antibody that binds to PD-1 with a KD value of 74 pM. Sintilimab blocks the interaction of PD-1 with its ligands (PD-L1 and PL-L2), consequently helping to restore the endogenous antitumour T-cell response. Sintilimab combined with prebiotics inhibits tumor volume and regulates immune cell subpopulation balance in lung adenocarcinoma mice. Sintilimab can be used for the research of classical Hodgkin's lymphoma, non-small cell lung cancer and oesophageal cancer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IBI308. CAS No. 2072873-06-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99048. | |
| Sipagladenant | Sipagladenant (Compound I) is an orally active adenosine receptor A2A inverse agonist[1]. Sipagladenant can be used in frontal lobe dysfunction research[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KW-6356. CAS No. 858979-50-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147400. | |
| Sipavibart | Sipavibart (AZD3152) is a human IgG1 λ2 monoclonal antibody against SARS-CoV-2. Sipavibart is applicable to research related to COVID-19. The isotype control product for Sipavibart is Human IgG1 lambda2, Isotype Control (HY-P990096)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD3152. CAS No. 2768288-97-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990766. | |
| Sipeimine | Sipeimine (Imperialine) is an inhibitor targeting the PI3K/AKT/NF-κB pathway and NLRP3 inflammasome, which can competitively bind to PI3K and p65. Sipeimine inhibits PI3K/AKT phosphorylation, blocks NF-κB nuclear translocation and NLRP3 inflammasome activation. Sipeimine exerts anti-inflammatory activities, inhibits pyroptosis and ferroptosis, and protects the extracellular matrix. Sipeimine can reduce cartilage degradation and synovial inflammation in osteoarthritis and improve PM2.5-induced lung injury. Sipeimine is mainly used in the study of anti-inflammatory and degenerative diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Imperialine. CAS No. 61825-98-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-N0696. | |
| Siplizumab | Siplizumab (MEDI-507) is a humanized IgG1 monoclonal antibody against CD2. Siplizumab depletes T cells, decreases T cell activation, inhibites T cell proliferation and enriches naïve and bona fide regulatory T cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MEDI-507; TCD601. CAS No. 288392-69-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99904. | |
| Siponimod | Siponimod (BAF-312) is an orally active, blood-brain barrier penetrant dual agonist of S1P1/S1P5, with EC50 values of 0.39 nM and 0.98 nM, respectively. Siponimod induces S1P1 internalization, activates GIRK channels, inhibits lymphocyte egress, reduces peripheral lymphocyte counts, triggers transient bradycardia, prevents synaptic neurodegeneration, promotes remyelination, alleviates demyelination, and prevents the loss of GABAergic interneurons. Siponimod can be used in research related to multiple sclerosis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAF-312. CAS No. 1230487-00-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-12355. | |
| Siramesine | Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist. Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0.12?nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17?nM). Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lu 28-179. CAS No. 147817-50-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14221. | |
| Siramesine hydrochloride | Siramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lu 28-179 hydrochloride. CAS No. 224177-60-0. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14221A. | |
| Siremadlin | Siremadlin (NVP-HDM201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NVP-HDM201; HDM201. CAS No. 1448867-41-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18658. | |
| Sirexatamab | Sirexatamab (DKN-01) is a humanized IgG4 monoclonal antibody that can bind to and neutralize circulating DKK1. Sirexatamab exhibits antitumor activity in tumor models expressing DKK1[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DKN-01; LY-2812176. CAS No. 2414962-49-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99906. | |
| Sirpiglenastat | Sirpiglenastat (DRP-104) is a broad acting glutamine antagonist. Sirpiglenastat has anticancer effects by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DRP-104. CAS No. 2079939-05-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-132832. | |
| SirReal-1 | SirReal-1 is a potent and selective Sirt2 inhibitor (IC50 = 3.7 μM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 801227-82-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123653. | |
| SirReal2 | SirReal2 is a potent, isotype-selective Sirt2 inhibitor with an IC50 value of 140?nM and has very little effect on the activities of Sirt3-5. SirReal2 leads to tubulin hyperacetylation in HeLa cells and induces destabilization of the checkpoint protein BubR1. SirReal2 combined with VS-5584 (HY-16585) suppresses tumor growth and extends the survival rate of mice in tumor xenograft model. SirReal2 is is promising for research of cancer, inflammation and neurodegeneration[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 709002-46-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100591. | |
| Sirt2-IN-1 | Sirt2-IN-1 (Compound 9) is a sirtuin 2 (Sirt2) inhibitor with an IC50 of 163 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1862238-00-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-112427. | |
| Sirt2-IN-2 | Sirt2-IN-2 (Compound 10) is a selective Sirt2 inhibitor with an IC50 of 0.118 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1862238-01-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112428. | |
| SIRT3 activator 2 | SIRT3 activator 2 (compound 2a) is a SIRT3 activator. SIRT3 activator 2 improved the thermal stability of SIRT3 in SH-SY5Y cells, indicating that it can directly bind to SIRT3, has SIRT3 dependency in SH-SY5Y to clear α-Syn. SIRT3 activator 2 improves motor function in Parkinson mice, preventing Parkinson (DA) neuron loss in the substantia nigra in a dose-dependent manner[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3061491-60-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163987. | |
| SIRT3-IN-1 | SIRT3-IN-1 (compound 17f) is a SIRT3 inhibitor, with IC50 of 0.043 μM. SIRT3-IN-1 can be used in the research of acute leukemia (AML)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3062836-46-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161920. | |
| SIRT4-IN-1 | SIRT4-IN-1 is a selective and potent Sirtuin 4 (Sirt4) inhibitor with an IC50 of 16 μM for hSirt4. SIRT4-IN-1 also inhibits hSirt1, hSirt2, hSirt3, hSirt4 and hSirt6. SIRT4-IN-1 competes with acyl peptide substrate for Sirt4's acyl binding site, and is noncompetitive with NAD+. SIRT4-IN-1 increases glutamate dehydrogenase (GDH) activity and rescues pyruvate dehydrogenase (PDH) activity. SIRT4-IN-1 inhibits adipocyte differentiation and suppresses Sirt4 overexpression-induced increased differentiation. SIRT4-IN-1 can be used for the researches of cancer and metabolic disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3030697-87-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163316. | |
| SIRT5 inhibitor 1 | SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 2166487-21-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-112634. | |
| SIRT6-IN-2 | SIRT6-IN-2 (Compound 5) is a selective and competitive SIRT6 inhibitor (IC50: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 891002-11-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103721. | |
| SIRT7 inhibitor 97491 | SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1807758-81-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135899. | |
| Sirtinol | Sirtinol is a sirtuin (SIRT) inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 410536-97-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13515. | |
| Sirukumab | Sirukumab (CNTO-136) is a humanized monoclonal anti-IL6 (Interleukin Related) IgG1κ antibody. Sirukumab binds to IL6, preventing IL6-mediated signal transduction and activation of transcriptional activators, thereby blocking the downstream biological effects of IL6. Sirukumab can be used in the study of active lupus nephritis and rheumatoid arthritis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CNTO-136. CAS No. 1194585-53-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99316. | |
| SIS17 | SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM. SIS17 inhibits the demyristoylation of serine hydroxymethyltransferase 2, a substrate of HDAC 11, but does not inhibit other HDACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2374313-54-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128918. | |
| SIS3 | SIS3 is a potent and selective inhibitor of Smad3 with an IC50 of 3 μM for Smad3 phosphorylation. SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 521984-48-5. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13013. | |
| SIS3 free base | SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 521985-36-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100444. | |
| Sisomicin sulfate | Sisomicin sulfate is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin sulfate is highly active against Gram-positive bacteria. Uses: Scientific research. Category: Signaling pathways. CAS No. 53179-09-2. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 250 mg; 500 mg. Product ID: HY-B1222. | |
| Sissotrin | Sissotrin (Biochanin A 7-glucoside) has potent antimicrobial and antioxidant activities. Sissotrin is active against the yeasts and Gram-positive and Gram-negative bacteria with MICs of 32-256 μg/mL[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Biochanin A 7-glucoside; Sissonin. CAS No. 5928-26-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N1240. | |
| Sisunatovir | Sisunatovir (RV521) is a potent and orally active respiratory syncytial virus (RSV) inhibitor with IC50 values of 1.4, 1.0 nM for RSV A, RSV B, respectively. Sisunatovir inhibits RSV infection and reduces virus titers in the lungs of mice[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RV521. CAS No. 1903763-82-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123475. | |
| Sisunatovir hydrochloride | Sisunatovir (RV521) hydrochloride is a potent and orally active respiratory syncytial virus (RSV) inhibitor with IC50 values of 1.4, 1.0 nM for RSV A, RSV B, respectively. Sisunatovir hydrochloride inhibits RSV infection and reduces virus titers in the lungs of mice[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RV521 hydrochloride. CAS No. 1903763-83-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123475A. | |
| Sitafloxacin hydrate | Sitafloxacin (DU6859a) hydrate is an orally active fluoroquinolone antibiotic (antibiotic) with in vitro activity against a wide range of Gram-positive and -negative bacteria, including anaerobic bacteria, as well as atypical pathogens. Sitafloxacin is used in the study of respiratory tract infections and urinary tract infections[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DU6859a hydrate. CAS No. 163253-35-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0395C. | |
| Sitagliptin | Sitagliptin (MK-0431) is an orally active and highly selective DPP4 inhibitor with an IC50 value of 19 nM. Sitagliptin blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) by competing inhibition mechanism (K? = 1 nM), thereby increasing the level of active incretin. Sitagliptin can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4. Sitagliptin shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin can be used for the study of 1-type and 2-type diabetes[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-0431. CAS No. 486460-32-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg. Product ID: HY-13749. | |
| Sitagliptin phosphate | Sitagliptin (MK-0431) phosphate is an orally active and highly selective DPP4 inhibitor with an IC50 value of 19 nM. Sitagliptin phosphate blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) by competing inhibition mechanism (K? = 1 nM), thereby increasing the level of active incretin. Sitagliptin phosphate can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4. Sitagliptin phosphate shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin phosphate can be used for the study of 1-type and 2-type diabetes[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-0431 phosphate. CAS No. 654671-78-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg. Product ID: HY-13749A. | |
| Sitagliptin phosphate monohydrate | Sitagliptin (MK-0431) phosphate monohydrate is an orally active and highly selective DPP4 inhibitor with an IC50 value of 19 nM. Sitagliptin phosphate monohydrate blocks the degradation of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) by competing inhibition mechanism (K? = 1 nM), thereby increasing the level of active incretin. Sitagliptin phosphate monohydrate can also directly stimulate the secretion of GLP-1 by intestinal L cells by activating the cAMP/PKA and ERK1/2 pathways, and this effect is independent of DPP-4. Sitagliptin phosphate monohydrate shows protective effects on pancreatic islet grafts in 1-type diabetes models. Sitagliptin phosphate monohydrate can be used for the study of 1-type and 2-type diabetes[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-0431 phosphate monohydrate. CAS No. 654671-77-9. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-13749B. | |
| Sitaxsentan sodium | Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC50 of 1.4 nM and a Ki of 0.43 nM. Sitaxsentan sodium exhibits an IC50 for the ETB receptor of as high as 9800 nM. Sitaxsentan sodium is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan sodium can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IPI 1040 sodium; TBC11251 sodium. CAS No. 210421-74-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-11103. | |
| Sitneprotafib | Sitneprotafib (JAB-3312) is an orally effective anticancer phosphatase SHP2 inhibitor (IC50: 1.9 nM) with anti-cancer activity. Sitneprotafib has good tolerability and significantly induced tumor regression in a KYSE-520 mouse xenograft model[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JAB-3312. CAS No. 2245082-05-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161952. | |
| Sitostanol | Stigmastanol is a 6-amino derivative. Stigmastanol can be isolated from Hypericum riparium. Stigmastanol increases the secretion of IL-2 and IL-10. Stigmastanol reduces the maximum mitochondrial respiration of cells. Stigmastanol has beneficial effects on the weakened immune function of asthma[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Stigmastanol; 24α-Ethyl cholestanol. CAS No. 83-45-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113494. | |
| Sitravatinib | Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively[1]. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MGCD516; MG-516. CAS No. 1123837-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-16961. | |
| Sivelestat | Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EI546; LY544349; ONO5046. CAS No. 127373-66-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17443. | |
| Sivelestat sodium | Sivelestat (EI546) sodium is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ONO5046-Na; Sodium sivelestat; EI546 sodium; LY544349 sodium. CAS No. 150374-95-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17443A. | |
| Sivelestat sodium tetrahydrate | Sivelestat (EI546) sodium tetrahydrate is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EI546 sodium tetrahydrate; LY544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate. CAS No. 201677-61-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17443B. | |
| Sivopixant | Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM). Sivopixant shows strong analgesic effect[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S-600918. CAS No. 2414285-40-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg. Product ID: HY-137451. | |
| SJ000063181 | SJ000063181 is a potent BMP signaling activator. SJ000063181 activates BMP4 and the phosphorylation of SMAD1/5/8 (p-SMAD1/5/8). SJ000063181 induces ventralization in zebrafish embryos[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 945189-68-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147372. | |
| SJ000291942 | SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. BMPs are members of the transforming growth factor beta (TGFβ) family of secreted signaling molecules. Uses: Scientific research. Category: Signaling pathways. CAS No. 425613-09-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112331. | |
| SJ-172550 | SJ-172550 is a small molecule inhibitor of MDMX; competes for the wild type p53 peptide binding to MDMX with an EC50 of 5 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 431979-47-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16664. | |
| SJ3149 | SJ3149 is a selective and potent molecular glue degrader of CK1α protein with broad antiproliferative activity. SJ3149 can be used in cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3026986-17-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160444. | |
| SJ572403 | SJ572403 (SJ403) is a p27Kip1 inhibitor. SJ572403 has high specificity for specific regions within the D2 subdomain of p27-KID with a Kd value of 2.2 mM. SJ572403 can be used for the research of diseases associated with intrinsically disordered proteins (IDPs)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SJ403. CAS No. 19970-45-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114712. | |
| SJ6986 | SJ6986 is a potent, selective and orally active GSPT1/2 Molecular Glue degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2765625-93-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132199. | |
| SJB2-043 | SJB2-043 is an inhibitor of the native USP1/UAF1 complex with IC50 of 544 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 63388-44-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15757. | |
| SJB3-019A | SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC50 of 0.0781 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 2070015-29-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-80012. | |
Would you like to list your products on USA Chemical Suppliers?
Our database is helping our users find suppliers everyday.