MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| (S)-Malic acid-13C4 | (S)-Malic acid-13C4 is the 13C labeled S-Malic acid (HY-Y1069)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-Hydroxybutanedioic acid-13C4; (S)-E 296-13C4; L-Malic acid-13C4. CAS No. 150992-96-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-Y1069S3. |  |
| SMAP-2 | SMAP-2 (DT-1154) is an orally active protein phosphatase 2A (PP2A) activator, with anti-cancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DT-1154. CAS No. 1809068-70-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-120272. | |
| SMAP-29 | SMAP - 29 is a cathelicidin antimicrobial peptide with LPS - binding and anti - inflammatory properties. SMAP - 29 exerts broad - spectrum antimicrobial activity against bacteria, fungi and multidrug - resistant isolates. SMAP - 29 kills pathogens by permeabilizing bacterial membranes, inducing depolarization and cell lysis, and also inhibits inflammatory cytokines while reducing lethality in septic shock and pneumonia models. SMAP-29 can be used for research on bacterial infections, drug-resistant infections, septic shock[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 172485-26-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2460. | |
| SMAPP1 | SMAPP1 is an activator of protein phosphatase-1 (PP1). SMAPP1 increases phosphorylation of CDK9s Ser90 and Thr186 residues, but not Ser175. SMAPP1 induces HIV-1 replication, upregulates HIV-1 transcription that led to the reactivation of latent HIV-1 provirus[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 327081-00-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-130514. | |
| SMARCA-BD ligand 1 for PROTAC | SMARCA-BD ligand 1 for PROTAC is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1997319-92-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-44012. | |
| SMARCA-BD ligand 1 for PROTAC hydrochloride | SMARCA-BD ligand 1 hydrochloride for PROTAC is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2380272-56-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-44012B. | |
| SmBiT Tag | SmBiT Tag is an 11-amino-acid short peptide with extremely low natural affinity for LgBiT, with a Kd value of approximately 190 μM. It serves as a core component of the NanoLuc Binary Technology (NanoBiT) system. NanoBiT is a bioluminescent reporter system based on protein fragment complementation technology, which is used to monitor dynamic protein-protein interactions in live cells and in vitro[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1628913-44-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P10633. | |
| SMCC | SMCC is a protein crosslinker. SMCC contains an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in the conjugation of proteins. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 64987-85-5. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g; 25 g; 100 g. Product ID: HY-42360. | |
| SMCC-DM1 | SMCC-DM1 (DM1-SMCC) is a agent-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker SMCC to make antibody agent conjugate (ADC)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DM1-SMCC. CAS No. 1228105-51-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101070. | |
| (S)-MCPG | (S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371)[1]. (S)-MCPG can be used for the study of the function of mGluRs in spatial learning[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-MCPG. CAS No. 150145-89-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100406. | |
| SMCy5.5 | SMCy5.5 is a SMCy dye (ex. 638 nm; em. 705 nm). The high brightness of SMCy5.5 allows for effective tracking and imaging of lipid droplet exchange between adipocytes. SMCy5.5 can be used for lipid droplet labeling studies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2417507-09-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-139337. | |
| SMD-3040 | SMD-3040 is a potent and selective SMARCA2 PROTAC degrader (DC50: 12 nM; Dmax: 91%). SMD-3040 can inhibit tumor cell proliferation and exhibits antitumor activity. SMD-3040 can be used in the study of tumors such as melanoma[1]. (SMARCA2/4-ligand (HY-171765); HY-112078 VHL ligand (HY-112078)). Uses: Scientific research. Category: Signaling pathways. CAS No. 3033109-92-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-156568. | |
| S-Me-DM4 | S-Me-DM4 is a metabolite of DM4 S-methylated by intracellular enzyme. DM4 (HY-100503) is a microtubule-depolymerizing maytansinoid with strong cytotoxicity. DM4 can be used as an ADC Cytotoxin molecule[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 890654-03-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148818. | |
| (S)-Mephenytoin | (S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsive agent. (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Mephenytoin. CAS No. 70989-04-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1184A. | |
| (S)-Mephenytoin (Standard) | (S)-Mephenytoin (Standard) is the analytical standard of (S)-Mephenytoin. This product is intended for research and analytical applications. (S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsive agent. (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Mephenytoin (Standard). CAS No. 70989-04-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1184AR. | |
| SMER28 | SMER28 is a positive regulator of autophagy acting via an mTOR-independent mechanism. SMER28 prevents the accumulation of amyloid beta peptide. Uses: Scientific research. Category: Signaling pathways. CAS No. 307538-42-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-100200. | |
| SMER3 | SMER3, a Rapamycin enhancer, is a selective Skp1-Cullin-F-box (SCF)Met30 ubiquitin ligase inhibitor. SMER3 enhances Rapamycin's growth inhibitory effect by inhibition of SCFMet30[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 67200-34-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10949. | |
| S-Methoprene | S-Methoprene is an insect juvenile hormone analog and effective insecticide that blocks the transition from pupa to adult. S-Methoprene is also a CB(1) receptor ligand and inhibits the binding of the CB1 receptor antagonist [3H]CP-55940 to the CB1 receptor (IC50: 19.31 μM)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Methoprene; (7S)-Methoprene. CAS No. 65733-16-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-B1161A. | |
| S-Methylglutathione | S-Methylglutathione is an S-substitued glutathione and a stronger nucleophile than GSH[1]. S-Methylglutathione has inhibitory effect on glyoxalase 1[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2922-56-7. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg. Product ID: HY-W009177. | |
| S-Methyl-L-cysteine | S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L-S-Methylcysteine. CAS No. 1187-84-4. Pack Sizes: 10 mM * 1 mL in Water; 1 g; 5 g; 10 g; 25 g. Product ID: HY-B2188. | |
| S-Methyl-N,N-diethylthiolcarbamate | S-Methyl-N,N-diethylthiolcarbamate (DETC-Me; DDTC-Me) is the active metabolite of the aldehyde dehydrogenase inhibitor disulfiram (HY-B0240). It is produced by the methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes. S-Methyl-N,N-diethylthiolcarbamate (DETC-Me; DDTC-Me) inhibits rat liver low Km aldehyde dehydrogenase (ALDH) (ID50=15.5 mg/kg). When administered at a dose of 20.6 mg/kg, it decreases mean arterial pressure (MAP) and increases heart rate in rats during ethanol stimulation. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DETC-Me; DDTC-Me; Diethyldithiocarbamic acid methyl ester. CAS No. 686-07-7. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-151229. | |
| S-Methyl thiomethanesulfonate | S-Methyl thiomethanesulfonate (MMTS) is a sulfur-containing volatile organic compound produced by plants and bacteria and is an effective anti-oomycete agent[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MMTS. CAS No. 2949-92-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W004461. | |
| SMI-10B13 | SMI-10B13 is an Oncostatin M (OSM) inhibitor with a KD of 6.6 μM. SMI-10B13 inhibits OSM-mediated STAT3 phosphorylation in T47D and MCF-7 cell lines (IC50 = 136 and 164 nM, respectively). SMI-10B13 shows anti-tumor effect in human breast cancer mice models[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3108487-29-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175465. | |
| SMI-4a | SMI-4a (TCS-PIM-1-4a) is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC50 of 24 μM and a Ki of 0.6 μM. SMI-4a also inhibits Pim-2 (IC50 of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TCS-PIM-1-4a. CAS No. 438190-29-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16576A. | |
| SMIFH2 | SMIFH2 is a formin specific inhibitor. SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 340316-62-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16931. | |
| Smilagenin | Smilagenin (SMI) is a small-molecule steroidal sapogenin from Anemarrhena asphodeloides and Pelargonium hortorum widely used in traditional Chinese medicine for treating chronic neurodegeneration diseases[1]. Smilagenin (SMI) improves memory of aged rats by increasing the muscarinic receptor subtype 1 (M1)-receptor density[2].Smilagenin (SMI) attenuates Aβ(25-35)-induced neurodegenerationvia stimulating the gene expression of brain-derived neurotrophic factor, may represents a novel therapeutic strategy for AD[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 126-18-1. Pack Sizes: 10 mM * 1 mL in Ethanol; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106353. | |
| SMIP004 | SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 143360-00-3. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15694. | |
| SMN-C3 | SMN-C3 is an orally active SMN2 splicing modulator and has the potential to treat spinal muscular atrophy (SMA). Uses: Scientific research. Category: Signaling pathways. CAS No. 1449597-34-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112633. | |
| SMPT | SMPT is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 112241-19-7. Pack Sizes: 100 mg; 250 mg; 1 g. Product ID: HY-126405. | |
| SMS1-IN-1 | SMS1-IN-1, compound SAPA 1j, is a novel and the most potent sphingomyelin synthase 1 (SMS1) inhibitor with an IC50 value of 2.1 μM. SMS1-IN-1 has the potential for the treatment of atherosclerosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1807943-38-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135642. | |
| SMS2-IN-1 | SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC50 of 1000 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2098890-15-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102041. | |
| SMS2-IN-2 | SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2241838-28-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112713. | |
| SMT-738 | SMT-738 is a bacterial bactericide. SMT-738 targets the small molecules responsible for lipoprotein transport in Enterobacteriaceae, causing abnormal lipoprotein localization and bacterial cell death. SMT-738 inhibits the growth of E. coli and K. pneumoniae. SMT-738 reduces bacterial loads in mouse models of urinary tract infection, bloodstream infection, and pulmonary infection caused by Enterobacterales. SMT-738 can be used in the research of Enterobacteriaceae infections, urinary tract infections, bloodstream infections, and pneumonia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2862851-15-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-157536. | |
| Smurf1-IN-1 | Smurf1-IN-1 is an orally active and selective inhibitor of specific E3 ubiquitin protein ligase 1 (SMURF1) with an IC50 of 92 nM. Smurf1-IN-1 has significant efficacy in rats model of pulmonary hypertension[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1824708-03-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149316. | |
| Smurf1-IN-A01 | Smurf1-IN-A01 is a Smurf1 inhibitor. Smurf1-IN-A01 has anticancer activity and can be used for the research of osteoporosis and age-related macular degeneration[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: A01. CAS No. 1007647-73-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110195. | |
| SMYD3-IN-1 | SMYD3-IN-1 (compound 29) is an irreversible and selective inhibitor of SMYD3 (SET and MYND domain containing 3), with an IC50 of 11.7 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2095160-79-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128352. | |
| SN-001 | SN-001 is a STING inhibitor with an IC50 of 3.82 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 727699-84-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W140974. | |
| SN-011 | SN-011 is a potent and selective mouse and human STING inhibitor, with an IC50 of 76 nM for STING signaling. SN-011 competes with cyclic dinucleotide (CDN) for the binding pocket of the STING dimer, blocking CDN binding and STING activation. SN-011 can be used for the research of STING-driven autoimmune and inflammatory disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2249435-90-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145010. | |
| SN05 | SN05 is a potent amino acid transport (AAT) inhibitor with Ki values of 2.77 μM, 0.73 μM, 0.87 μM, 3.7 μM, 7.25 μM, 7.23 μM and 2.22 μM for hASCT1, rASCT2, hASCT2, EAAT1, EAAT2, EAAC1 and EAAT5, respectively. SN05 can be used in the study of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2768663-51-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146242. | |
| SN-38 | SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 can bind to RPL15. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254)[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-Ethyl-10-hydroxycamptothecin. CAS No. 86639-52-3. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-13704. | |
| SN-38-CO-DMEDA TFA | SN-38-CO-DMEDA TFA is the intermediate product for synthesizing antibody-conjugated drug LND1035[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1224601-17-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145767A. | |
| SN38-COOH | SN38-COOH is used for the synthesis of antibody-drug conjugates (ADCs). SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2170118-23-5. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-153013. | |
| SN-38-d3 | SN-38-d3 is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NK012-d3. CAS No. 718612-49-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-13704S. | |
| SN-38 glucuronide | SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan (HY-16562) and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SN-38G. CAS No. 121080-63-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-126373. | |
| SN-38 (Standard) | SN-38 (Standard) is the analytical standard of SN-38. This product is intended for research and analytical applications. SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254)[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7-Ethyl-10-hydroxycamptothecin (Standard). CAS No. 86639-52-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13704R. | |
| (S)-(+)-N-3-Benzylnirvanol | (S)-(+)-N-3-Benzylnirvanol ((+)-N-3-Benzylnirvanol) is a selective and competitive cytochrome P450 (CYP) isoform CYP2C19 inhibitor with a Ki of 250 nM. (S)-(+)-N-3-Benzylnirvanol has low activity against CYP1A2, CYP2A6, CYP2C8, CYP2C9, CYP2D6, CYP2E1, and CYP3A4[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-N-3-Benzylnirvanol. CAS No. 790676-40-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W013268. | |
| (S)-N-(4-((3-Methoxy-4-(2-methyl-2H-1,2,3-triazol-4-yl)pyridin-2-yl)amino)-5-propionylpyridin-2-yl)spiro[2.2]pentane-1-carboxamide-d3 | (S)-N-(4-((3-Methoxy-4-(2-methyl-2H-1,2,3-triazol-4-yl)pyridin-2-yl)amino)-5-propionylpyridin-2-yl)spiro[2.2]pentane-1-carboxamide-d3. Uses: Scientific research. Category: Isotope-labeled compounds. CAS No. 3062086-74-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-181938S. | |
| SN50 | SN50 is a cell permeable inhibitor of NF-κB translocation. Uses: Scientific research. Category: Signaling pathways. CAS No. 213546-53-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0151. | |
| SN52 | SN52 is a potent, competitive, and cell-permeable inhibitor of NF-κB2. SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. SN52 can be used for cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1071173-56-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3229. | |
| Snailase, Snail gastrointestinal | Snailase, Snail gastrointestinal is an enzyme mixture composed of more than 20 enzymes, which is often used for enzymatic hydrolysis of purified flavonoid glycosides. Snailase can be obtained from the digestive tract and includes cellulase, sucrase, hemicellulase, pectinase, polygalacturonase, protease, etc[1]. Uses: Scientific research. Category: Enzymes. CAS No. 158736-45-9. Pack Sizes: 5 g. Product ID: HY-E70130. | |
| Snail IN-1 | Snail IN-1 is an orally active Snail inhibitor with a Ka of 0.36 μM.Snail IN-1 disrupts Snail-CBP interaction, accelerates Snail protein degradation, reduces Snail acetylation, increases Snail polyubiquitination, and selectively downregulates Snail protein without altering other EMT transcription factors.Snail IN-1 reduces atherosclerotic plaque burden, modulates inflammation and plaque stability factors, downregulates CCL5, CXCL10, MMP2, and MMP9, and upregulates α-smooth muscle actin.Snail IN-1 exerts anti-inflammatory and plaque-stabilizing properties.Snail IN-1 can be used for the research of atherosclerosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3083216-69-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-181654. | |
| (S)-Navlimetostat | (S)-Navlimetostat (example 16-7) is the S-enantiomer of Navlimetostat. (S)-Navlimetostat is a PRMT5/MTA complex inhibitor, with an IC50 of 7070 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-MRTX-1719; (S)-BMS-986504. CAS No. 2630904-44-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-139611B. | |
| S-n-Butyrylthiocholine iodide | S-n-Butyrylthiocholine iodide is a substrate of BChE. S-n-Butyrylthiocholine iodide commonly used for in vitro enzymatic experiments[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1866-16-6. Pack Sizes: 10 mM * 1 mL in DMSO; 10 g; 25 g. Product ID: HY-D0905. | |
| SNC162 | SNC162 is a delta-opioid receptor agonist with an IC50 of 0.94 nM. SNC162 has antidepressant-like and antinociceptiv effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 178803-51-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-107741. | |
| SNC80 | SNC80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist with a Ki of 1.78 nM and an IC50 of 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant?like effects. SNC80 has the potential for multiple headache disorders treatment[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NIH 10815. CAS No. 156727-74-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101202. | |
| sn-Glycero-3-phosphocholine | sn-Glycero-3-phosphocholine (Choline Alfoscerate) is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. sn-Glycero-3-phosphocholine (Choline Alfoscerate) has significant effects on cognitive function with a good safety profile and tolerability, and is effective in the treatment of Alzheimer's disease and dementia[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Choline Alfoscerate; Alpha-GPC; L-α-GPC. CAS No. 28319-77-9. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-17552. | |
| (S)-NIK SMI1 | (S)-NIK SMI1 is the isomer of NIK SMI1 (HY-112433), and can be used as an experimental control. NIK SMI1 is a potent, selective NF-κB inducing kinase (NIK) inhibitor, which inhibits NIK-catalyzed hydrolysis of ATP to ADP with IC50 of 0.23±0.17 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 2984765-48-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112433A. | |
| (S)-Nimodipine | (S)-Nimodipine ((S)-BAY-e 9736) is an enantiomer of Nimodipine. Nimodipine (BAY-e 9736) is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used for the research of cerebrovascular disorders[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-BAY-e 9736. CAS No. 77940-93-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0265B. | |
| SNIPER(BRD)-1 | SNIPER(BRD)-1 is a SNIPER degrader of BRD4, cIAP1 and XIAP. SNIPER(BRD)-1 has IC50 values of 6.8 nM, 17 nM and 49 nM for cIAP1, cIAP2 and XIAP, respectively. SNIPER(BRD)-1 can be used for cancer research[1]. (Blue: LCL161 (HY-15518); Black: linker (HY-W008005); Pink: (+)-JQ-1 (HY-13030)). Uses: Scientific research. Category: Signaling pathways. CAS No. 2095244-54-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-111875. | |
| SNIPER(ER)-87 | SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2222354-91-6. Pack Sizes: 5 mg. Product ID: HY-129619. | |
| S-Nitroso-N-acetyl-DL-penicillamine | S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a nitric oxide donor and acts as a stable inhibitor of platelet aggregation[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SNAP. CAS No. 67776-06-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121526. | |
| SNOTRAP | SNOTRAP (S-nitrosylation trapping by triaryl phosphine) is a chemical probe for S-nitrosylated (SNO) proteins. SNOTRAP based proteomic pipeline can identify 1181 SNO proteins (1714 SNO sites) in the brain of mouse models. SNOTRAP can be used for nitrosative stress related diseases such as neurodegenerative disease, endotoxic shock, cancer, multiple sclerosis, and sickle cell disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2080332-70-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D2902. | |
| SNS-032 | SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK2, CDK7, and CDK9 with IC50s of 38 nM, 62 nM and 4 nM, respectively. SNS-032 has antitumor effect[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-387032. CAS No. 345627-80-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-10008. | |
| SNS-314 mesylate | SNS-314 mesylate is a potent and selective aurora kinase inhibitor with IC50s of 9, 31, and 6 nM for aurora A, B and C, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1146618-41-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12003. | |
| SNT-207707 | SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor. SNT-207707 can cross blood-brain barrier[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1064662-40-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11029. | |
| SNT-5382 | SNT-5382 is a lysyl oxidase family (LOX) inhibitor and anti-fibrotic agent. SNT-5382 binds to the LTQ cofactor of LOXL2 and inhibits the enzymatic activities of LOXL3, LOXL4, LOXL1, CYP2C9, and CYP2C19. SNT-5382 reduces cardiac and liver fibrosis as well as collagen crosslinks, and improves cardiac function. SNT-5382 can be used for the research of heart failure, myocardial infarction, and nonalcoholic steatohepatitis-related liver fibrosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2125956-92-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-170538. | |
| SNX281 | SNX281 is a selective STING agonist, with IC50 values of 4.1, 4.5, 10.7, and 3.7 μM against human, mouse, rat, and monkey STING, respectively. SNX281 undergoes homodimerization at the STING binding site, triggering a conformational shift of STING from an inactive open state to an active closed state, thereby driving downstream STING-dependent signaling pathways. SNX281 induces type I interferons, IFN-β, TNF-α, IL-6, cytokine release, T cell responses, and long-lasting immune memory. SNX281 exhibits anti-tumor activity and is applicable to research related to colorectal cancer, melanoma, advanced solid tumors, lymphoma, and ovarian cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2332803-84-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160406. | |
| SNX-5422 | SNX-5422 (PF-04929113), a prodrug of SNX-2112, is an orally active Hsp90 inhibitor, with a Kd of 41 nM, and also induces Her-2 degradation, with an IC50 of 37 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-04929113. CAS No. 908115-27-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10213. | |
| SNX7886 | SNX7886 is a CDK8/CDK19 PROTAC degrader. SNX7886 promotes the ubiquitination and degradation of CDK8 and CDK19. SNX7886 also promotes the degradation of CCNC. SNX7886 can be used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2924557-42-4. Pack Sizes: 500 μg; 1 mg. Product ID: HY-156366. | |
| Sobetirome | Sobetirome (GC-1) is a thyroid hormone receptor β (TRβ)-specific agonist which bind selectively to TRβ-1 with an EC50 of 0.16 μM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GC-1; QRX-431. CAS No. 211110-63-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14823. | |
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