MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| SP600125 | SP600125 is an orally active, reversible, and ATP-competitive JNK inhibitor with IC50s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is a potent ferroptosis inhibitor. SP600125 induces the transformation of bladder cancer cells from autophagy to apoptosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 129-56-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12041. |  |
| SP-96 | SP-96 is a highly potent, selective and non-ATP-competitive Aurora B (IC50=0.316 nM) inhibitor and shows >2000 fold selectivity against FLT3 and KIT. SP-96 shows selective growth inhibition in NCI60 screening, incluing MDA-MD-468 (GI50=107 nM). SP-96 can be used for the research of triple negative breast cancer (TNBC)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2682114-54-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131339. | |
| SPA0355 | SPA0355 is a thiourea derivative that has antioxidant and anti-inflammatory properties. SPA0355 inhibits the RANKL (receptor activator of nuclear factor κB ligand) induced osteoclast formation in primary bone marrow-derived macrophages. SPA0355 also suppresses the activation of the MAPKs, Akt, and NF-κB pathways. Additionally, SPA0355 promotes osteoblast differentiation, increases alkaline phosphatase activity, and enhances mineral nodule formation. SPA0355 can protect ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it useful for studying postmenopausal osteoporosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1251839-15-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-169703. | |
| SPA70 | SPA70 is a potent and selective antagonist of human pregnane X receptor (hPXR), with an IC50 of 540 nM (Ki=390 nM). SPA70 can enhance the chemosensitivity of cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 931314-31-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124830. | |
| SPACE peptide | SPACE peptide is a skin penetrating peptide (SPPs). SPACE peptide can enhance topical delivery of a macromolecule, hyaluronic acid[1][2][3]. Uses: Scientific research. Category: Peptides. CAS No. 1621717-95-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0123. | |
| Spadin | Spadin, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with IC50 value of 10 nM. Spadin enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin can be used for antidepressant research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1270083-24-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1422. | |
| (S)-Padsevonil | (S)-Padsevonil is the S-enantiomer of Padsevonil (HY-109009).Padsevonil (UCB0942) is a potent antiepileptic agent that selectively acts on presynaptic and postsynaptic targets. Padsevonil binds to synaptic vesicular protein 2 (SV2) with high affinity. Padsevonil is also a positive allosteric modulator and partial agonist of GABAAR, with high potency against α1 and α5 receptors. Padsevonil has antiepileptic effects in a variety of rodent models[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-UCB-0942. CAS No. 1294001-37-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109009A. | |
| Spaglumic acid | Spaglumic acid (N-Acetylaspartylglutamic acid) is a neuropeptide found in millimolar concentrations in brain. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Acetylaspartylglutamic acid. CAS No. 3106-85-2. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100921. | |
| Spantide I | Spantide I, a substance P analog, is a selective NK1 receptor antagonist, with Ki values of 230 nM and 8150 nM for NK1 and NK2 receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 91224-37-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1194. | |
| Spantide II | Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 129176-97-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1722. | |
| Sparfosic acid | Sparfosic acid, a DNA antimetabolite agent, is a potent inhibitor of aspartate transcarbamoyl transferase, the enzyme catalyzing the second step of de novo pyrimidine biosynthesis. Sparfosic acid synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 51321-79-0. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg. Product ID: HY-112732. | |
| Sparfosic acid trisodium | Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase. Aspartate transcarbamoyl transferase catalyzes the second step of de novo pyrimidine biosynthesis. Sparfosic acid trisodium synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 70962-66-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112732B. | |
| Sparsentan | Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RE-021; DARA-a. CAS No. 254740-64-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17621. | |
| Sparstolonin B | Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1259330-61-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116213. | |
| (+)-Sparteine | (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pachycarpine. CAS No. 492-08-0. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-W008350. | |
| Spastazoline | Spastazoline is a selective spastin (a microtubule-severing AAA protein) inhibitor, with an IC50 of 99 nM for Human spastin. Spastazoline can be used for cell division- and intracellular vesicle transport-related research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2351882-11-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111548. | |
| Spathulenol | Spathulenol is isolated from Aristolochia yunnanensis, and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC50 of 85.60 μg/mL in the DPPH system[1]. Uses: Scientific research. Category: Natural products. CAS No. 6750-60-3. Pack Sizes: 1 mg. Product ID: HY-N1205. | |
| Spautin-1 | Spautin-1 is a specific and potent autophagy inhibitor which inhibits ubiquitin-specific peptidases, USP10 and USP13 with IC50s of 0.6-0.7 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1262888-28-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12990. | |
| SPC 839 | SPC 839 (compound 10) is an orally active inhibitor of AP-1 and NF-kB mediated transcriptional activation with IC50 of 0.008 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 219773-55-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10072. | |
| SPD304 | SPD304 is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 869998-49-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-111255. | |
| SPD304 dihydrochloride | SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1049741-03-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111255A. | |
| SPDB-DM4 | SPDB-DM4 is a agent-linker conjugate for ADC by using the maytansinebased payload (DM4, a tubulin inhibitor) via a SPDB linker, exhibiting potent anti-tumor activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 1626359-62-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12460. | |
| SPDMV | SPDMV is a glutathione cleavable ADC linker used for the antibody-drug conjugate (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 890409-85-5. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-129368. | |
| SPDP | SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SPDP Crosslinker; Py-ds-Prp-OSu. CAS No. 68181-17-9. Pack Sizes: 25 mg; 50 mg; 100 mg; 200 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-100216. | |
| SPDP-PEG4-NHS ester | SPDP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1334177-95-5. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-130195. | |
| SpeB cysteine protease | SpeB cysteine protease is a potent modifier of immunologically important host and bacterial proteins. SpeB cysteine protease degrades streptolysin O (SLO) in extracellular vesicles[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9025-51-8. Pack Sizes: 2 KU. Product ID: HY-E70420. | |
| Spebrutinib | Spebrutinib (AVL-292; CC-292) is a covalent, orally active, and highly selective with an IC50 of 0.5 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AVL-292; CC-292. CAS No. 1202757-89-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18012. | |
| Specnuezhenide | Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (8E)-Nuezhenide. CAS No. 39011-92-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0665. | |
| Spectinomycin dihydrochloride | Spectinomycin dihydrochloride is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin dihydrochloride acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin dihydrochloride is also a noncompetitive inhibitor of td intron RNA with an Ki value of 7.2 mM[1]-[5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 21736-83-4. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g; 25 g. Product ID: HY-B0438. | |
| Spectinomycin dihydrochloride pentahydrate | Spectinomycin dihydrochloride pentahydrate is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin dihydrochloride pentahydrate acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin dihydrochloride pentahydrate is also a noncompetitive inhibitor of td intron RNA with an Ki value of 7.2 mM[1]-[5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Spectinomycin hydrochloride hydrate. CAS No. 22189-32-8. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g. Product ID: HY-B1828A. | |
| SPEN-IN-1 | SPEN-IN-1 (compound X1) is an inhibitor of SPEN which is a protein factor with a Kd value of 47 nM. SPEN-IN-1 has high selectivity for RepA, a 431-nucleotide domain in Xist (a non-coding RNA prototype) that comprises 8.5 units of a GC-rich motif responsible for gene silencing[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2863686-82-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152038. | |
| Spermidine | Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 124-20-9. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g; 5 g; 25 g. Product ID: HY-B1776. | |
| Spermidine-d6 | Spermidine-d6 is the deuterium labeled Spermidine[1]. Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2514812-10-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B1776S. | |
| Spermidine hydrochloride | Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H2O2 and O2.- contents[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 334-50-9. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 1 g; 5 g. Product ID: HY-B1776A. | |
| Spermidine (Standard) | Spermidine (Standard) is the analytical standard of Spermidine. This product is intended for research and analytical applications. Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 124-20-9. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-B1776R. | |
| Spermine | Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 268508; Neuridine. CAS No. 71-44-3. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B1777. | |
| Spermine-d8 tetrahydrochloride | Spermine-d8 (tetrahydrochloride) is the deuterium labeled Spermine tetrahydrochloride. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1173022-85-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-B1777AS. | |
| Spermine NONOate | Spermine NONOate is a complex of nitric oxide (NO) with spermine and acts as a NO donor. Spermine NONOate can be used for NO aqueous solutions preparing[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 136587-13-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-101394. | |
| Spermine tetrahydrochloride | Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 306-67-2. Pack Sizes: 10 mM * 1 mL in Water; 100 mg. Product ID: HY-B1777A. | |
| Spesolimab | Spesolimab (BI 655130) is a mouse-derived humanized IgG1k antibody against IL-36R. IL-36 plays an important role in the immune system and Spesolimab is being investigated in palmoplantar pustulosis (PPP). Spesolimab was associated with a reduction in biomarkers associated with the innate, Th1/Th17 and neutrophil pathways[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BI 655130. CAS No. 2097104-58-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99396. | |
| Spexin | Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Neuropeptide Q. CAS No. 1370290-58-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1723. | |
| S-Phenylmercapturic acid (Standard) | S-Phenylmercapturic acid (Standard) is the analytical standard of S-Phenylmercapturic acid. This product is intended for research and analytical applications. S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4775-80-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130189R. | |
| Sphinganine-C17 | Sphinganine-C17 (Heptadecasphinganine) is a synthetic bioactive sphingolipid and an isomer of sphinganine. Sphinganine-C17 inhibits the growth of Candida glabrata and Candida albicans with a minimum bactericidal concentration (MBC) of 0.5 μg/mL for both. Sphinganine-C17 can be used as an internal standard for the chromatographic analysis of sphingosine compounds[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Heptadecasphinganine. CAS No. 32164-02-6. Pack Sizes: 500 μg; 1 mg. Product ID: HY-141632. | |
| Sphingomyelin | Sphingomyelin is a eukaryotic sphingolipid and one of the major constituents of cell membranes and particularly abundant in the myelin sheath that surrounds neuronal axons. Sphingomyelin plays an important role in cell processes, the regulation of inflammatory responses, and signal transduction. Sphingomyelin metabolism is associated with various central nervous system diseases and Niemann-Pick disease[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 85187-10-6. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113498. | |
| SPHINX31 | SPHINX31 is a potent and selective SRPK1 inhibitor, with an IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1). SPHINX31 also decreases the mRNA expression of pro-angiogenic VEGF-A165a isoform. SPHINX31 can be used to research neovascular eye disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1818389-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-117661. | |
| Sphondin | Sphondin possesses an inhibitory effect on IL-1β-induced increase in the level of COX-2 protein and PGE2 release in A549 cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 483-66-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2429. | |
| (S)-PI3Kα-IN-4 | (S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2.3 nM. (S)-PI3Kα-IN-4 shows 38.3-, 4.25-, and 4.93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (S)-PI3Kα-IN-4 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2322293-84-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131345A. | |
| Spinacine | Spinacine ((S)-Spinacine) is a GABA uptake inhibitor. Spinacine enhances synaptic GABA effects via inhibition of gamma-aminobutyric acid uptake in cerebral cortex slices. Spinacine inhibits reflex responses of ventral roots in isolated spinal cord. Spinacine inhibits motor activity and reduces approaches to water dispensers in conflict situations. Spinacine raises pain sensitivity threshold via subarachnoidal injection[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-Spinacine. CAS No. 59981-63-4. Pack Sizes: 10 mM * 1 mL in Water; 100 mg. Product ID: HY-W067716. | |
| Spinosad | Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete (Saccharopolyspora spinosa), is a biological neurotoxic insecticide with a broader action spectrum. Spinosad targets the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system. Spinosad has an excellent environmental and mammalian toxicological profile. Larvicidal activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 168316-95-8. Pack Sizes: 100 mg; 500 mg. Product ID: HY-138800. | |
| Spiperone | Spiperone (Spiroperidol) is a potent dopamine D2, serotonin 5-HT1A, and serotonin 5-HT2A antagonist. Spiperone is also a labelled ligand for neuroleptic receptors. Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway. Spiperone has the potential for the research of neurology diseases[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Spiroperidol. CAS No. 749-02-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1371. | |
| Spiperone hydrochloride | Spiperone hydrochloride (Spiroperidol hydrochloride) is a selective dopamine D2 receptor (Ki values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D2, D3, D4, D1 and D5 receptors, respectively) and 5-HT2A/5-HT1A receptor (Kis of 1 nM/49 nM) antagonist. Spiperone hydrochloride is also a selective α1B-adrenoceptor antagonist. Spiperone hydrochloride activates calcium-activated chloride channel (CaCC). Antipsychotic and anti-inflammatory activities[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Spiroperidol hydrochloride. CAS No. 2022-29-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-B1371A. | |
| Spiramycin | Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect. Spiramycin is composed of a 16-member lactone ring, on which three sugars (mycaminose, forosamine, and mycarose) are attached[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Rovamycin. CAS No. 8025-81-8. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-100593. | |
| Spiro-MeOTAD | Spiro-MeOTAD is a high performance hole transport layer material. Spiro-MeOTAD can be used in highly efficient perovskite solar cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 207739-72-8. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W025445. | |
| Spironolactone | Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca2+ channels to exert antihypertensive effects[1][2][3][4][5][6][7][8][9][10]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SC9420. CAS No. 52-01-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 1 g; 5 g. Product ID: HY-B0561. | |
| Spiropyran hexyl methacrylate | Spiropyran hexyl methacrylate is a compound used to prepare spiropyran-based polymer hydrogels, which can be used in research on photoactivated mechanical drives[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2522597-48-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137477. | |
| SPL-707 | SPL-707 is an orally active, selective signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC50 of 77 nM for hSPPL2a. SPL-707 inhibits γ-secretase (IC50=6.1 μM) and SPP (IC50=3.7 μM). SPL-707 has the potential for autoimmune diseases research by targeting B cells and dendritic cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2195361-33-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-111360. | |
| Spliceostatin A | Spliceostatin A, the FR901464 (HY-16212) methylated derivative, is a potent anti-tumor agent. Spliceostatin A inhibits splicing and promotes pre-mRNA accumulation by binding SF3B1. SF3B1 is a subcomplex of U2 small nuclear ribonucleoprotein in the spliceosome. Spliceostatin A induces Apoptosis in chronic lymphocytic leukemia (CLL) cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 391611-36-2. Pack Sizes: 100 μg; 1 mg; 5 mg. Product ID: HY-16466. | |
| Splitomicin | Splitomicin (Splitomycin) is a selective Sir2p inhibitor. Splitomicin inhibits NAD+-dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC50 of 60 μM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Splitomycin. CAS No. 5690-3-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100585. | |
| S-(p-Nitrobenzyl)glutathione | S-(p-Nitrobenzyl)glutathione is a competitive glutathionase inhibitor. S-(p-Nitrobenzyl)glutathione is converted to the corresponding cysteine derivatives by rat kidney microsomes. S-(p-Nitrobenzyl)glutathione can be used for the research of metabolic breakdown of glutathione by the glutathionase system[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6803-19-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148208. | |
| Spongosine | Spongosine (2-Methoxyadenosine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Methoxyadenosine; 2-O-Methylisoguanosine. CAS No. 24723-77-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-105006. | |
| SPOP-IN-6b | SPOP-IN-6b is a speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 μM (patent CN 107141287, SPOP-B-88)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2136270-20-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122615. | |
| SPP-86 | SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. SPP-86 inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells[1]. SPP-86 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1357349-91-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110193. | |
| SPP-DM1 | SPP-DM1 is a agent-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker SPP[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 452072-20-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-126491. | |
| SppIP | SppIP (Sakacin P inducer peptide) is a peptide consisting of 19 amino acids. SppIP is an essential inducer for sakacin P production. SppIP can induce the expression of PRRSV GP5 and SARS-CoV-2 spike protein in recombinant Lactobacillus plantarum. SppIP can activate the transcription of the sakacin P promoter to drive the expression of downstream heterologous capsid proteins, increasing the proportion of PCV2d capsid proteins displayed on the cell surface of Lactobacillus plantarum. SppIP can be used in studies related to sakacin P induction[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sakacin P inducer peptide. CAS No. 175483-64-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P11146. | |
| SPR719 | SPR719 (VXc-486) is an orally active gyrase B inhibitor, with bactericidal activity. SPR719 potently inhibits multiple agent-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis, with MICs of 0.03 to 0.30 μg/ml and 0.08 to 5.48 μg/ml, respectively. SPR719 is promising for research of lung disease caused by non-tuberculous mycobacteria (NTM)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VXc-486. CAS No. 1384984-18-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12930. | |
| SPR741 | SPR741 (NAB741) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NAB741. CAS No. 1179330-52-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1649. | |
| (S)-Praziquantel | S)-Praziquantel is a inactive distomer of R-praziquantel[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 57452-97-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126057A. | |
| SPR inhibitor 3 | SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SPRi3. CAS No. 1292285-54-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115510. | |
| (S)-(-)-Propranolol hydrochloride | (S)-(-)-Propranolol hydrochloride is a chiral antihypertensive agent with approximately 100-fold higher potency than its R-enantiomer. (S)-(-)-Propranolol hydrochloride can be used for studies on hypertension, angina pectoris and arrhythmia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4199-10-4. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-B0573A. | |
| SPSB2-iNOS inhibitory cyclic peptide-1 | SPSB2-iNOS inhibitory cyclic peptide-1 is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with KD of 4.4 nM. SPSB2-iNOS inhibitory cyclic peptide-1 is resistant to the proteases pepsin, trypsin and α-chymotrypsin. SPSB2-iNOS inhibitory cyclic peptide-1 is stable in human plasma and in oxidative environment[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1621616-13-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10383. | |
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