MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Staurosporine | Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Antibiotic AM-2282; STS; AM-2282. CAS No. 62996-74-1. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15141. |  |
| Staurosporine (Standard) | Staurosporine (Standard) is the analytical standard of Staurosporine. This product is intended for research and analytical applications. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Antibiotic AM-2282 (Standard); STS (Standard); AM-2282 (Standard). CAS No. 62996-74-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15141R. | |
| Stavudine | Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: d4T. CAS No. 3056-17-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-B0116. | |
| STC-15 | STC-15 is an orally active RNA methyltransferase METTL3 inhibitor with the activity of activating anti-tumor immunity and reshaping the tumor microenvironment. STC-15 inhibits tumor growth by activating anti-cancer immune responses associated with increased interferon signaling and synergizes with T-cell checkpoint blockade. STC-15 can be used in the study of proliferative diseases such as cancer and autoimmune diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2648257-56-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-156677. | |
| Stearic acid | Stearic acid is an orally active long-chain dietary saturated fatty acid that can significantly reduce visceral fat by inducing apoptosis of preadipocytes. Stearic acid can be used in the study of cardiovascular and metabolic diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 57-11-4. Pack Sizes: 500 mg; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-B2219. | |
| Stearic acid-13C18 | Stearic acid-13C18is the 13C-labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils. Uses: Scientific research. Category: Signaling pathways. CAS No. 287100-83-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-B2219S2. | |
| Stearic acid-d35 | Stearic Acid-d35 is the deuterium labeled Stearic acid. Stearic acid is a long chain dietary saturated fatty acid which exists in many animal and vegetable fats and oils. Uses: Scientific research. Category: Signaling pathways. CAS No. 17660-51-4. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-B2219S4. | |
| Stearoylethanolamide | Stearoylethanolamide is an endocannabinoid-like compound with pro-apoptotic activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 111-57-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-113015. | |
| Stearoyl-L-carnitine-d3 chloride | Stearoyl-L-carnitine-d3 (chloride) is the deuterium labeled Stearoyl-L-carnitine chloride. Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2245711-27-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-130466S. | |
| Stem bromelain | Stem bromelain (EC 3.4.22.32) is a cysteine protease and antibacterial agent. Stem bromelain can be isolated from the stem of the pineapple (Ananas comosus). Stem bromelain induces dose-dependent secretion of IL-12p70, and IL-6, induces Apoptosis, causes cleavage of full-length PARP protein, Caspase 3, and Caspase 9, increases Bax, and decreases Bcl-2. Stem bromelain possesses various fibrinolytic, antiedema, antithrombotic, and anti-inflammatory activities. Stem bromelain also exhibits in vivo antitumor and antileukemic activities, as well as antimetastatic effects. Stem bromelain has antimycobacterial activity. Stem bromelain provides protection against lead poisoning[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 37189-34-7. Pack Sizes: 5 g; 25 g; 100 g. Product ID: HY-P2970. | |
| Stemregenin 1 | Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with IC50 of 127 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SR1. CAS No. 1227633-49-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15001. | |
| Stenoparib | Stenoparib (E7449) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ~50 and ~50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate. Uses: Scientific research. Category: Signaling pathways. Alternative Names: E7449; 2X-121. CAS No. 1140964-99-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12418. | |
| Steppogenin | Steppogenin is a potent inhibitor of HIF-1α and DLL4, with IC50 values of 0.56 and 8.46 μM, respectively. Steppogenin can be sued for the research of angiogenic diseases, such as those involving solid tumors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 56486-94-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-122094. | |
| Sterculic acid | Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC50 value of 0.9 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 738-87-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-127143. | |
| Sternbin | Sternbin (Eriodictyol 7-methyl ether) is a flavanone and antibacterial agent. Sternbin can be isolated from Heliotropium sinuatum. Sternbin has antibacterial activity against a wide range of bacteria. Sternbin has antiviral activity against infectious salmon anemia virus (ISAV). Sternbin inhibits the contraction of isolated rat smooth muscle[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Eriodictyol 7-methyl ether; 7-O-Methyleriodictyol. CAS No. 51857-11-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2754. | |
| Steviol | Steviol is the main metabolite of steviol glycosides and an inhibitor of AQP2/CFTR. Steviol slows down the growth of renal cysts by inhibiting the activity of CFTR, reducing the expression of AQP2, and promoting the degradation of AQP2 and CFTR. Steviol can be used in the research of polycystic kidney disease[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 471-80-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2057. | |
| Stevioside | Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana, with antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory and anti-tumor activities[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 57817-89-7. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0669. | |
| Stevioside (Standard) | Stevioside (Standard) is the analytical standard of Stevioside. This product is intended for research and analytical applications. Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana, with antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory and anti-tumor activities[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 57817-89-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0669R. | |
| STF-083010 | STF-083010 is a specific IRE1α inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress. Uses: Scientific research. Category: Signaling pathways. CAS No. 307543-71-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15845. | |
| STF-1084 | STF-1084 is a specific, cell-impermeable, competitive inhibitor of ENPP1 (Ki = 33 nM). STF-1084 increases extracellular cGAMP concentrations by preventing its degradation by ENPP1, thereby enhancing immune infiltration. STF-1084 acts synergistically with ionizing radiation (IR) and cGAMP to delay tumor progression. STF-1084 can be used to study cancers with low immunogenicity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2298390-71-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-141831. | |
| STF-118804 | STF-118804 is a highly specific NAMPT inhibitor. STF-118804 activates AMPK and inhibits mTOR pathways. STF-118804 has antitumor activity against pancreatic cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 894187-61-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12808. | |
| STF-31 | STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC50 of 1 μM. STF-31 is also a NAMPT inhibitor. STF-31 inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 724741-75-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18728. | |
| STF-62247 | STF-62247 is an autophagy inducer that selectively cytotoxic to VHL-deficient renal cell carcinoma (IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 315702-99-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100746. | |
| STh | STh, an Escherichia coli heat-stable toxin, is a 19 amino acid polypeptide encompassing three disulfide bridges. STh is an antigen of interest in the search for a broad coverage enterotoxigenic Escherichia coli (ETEC) vaccine[1]. Uses: Scientific research. Category: Peptides. CAS No. 118447-40-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2695. | |
| (S)-Thalidomide | (S)-Thalidomide ((S)-(-)-Thalidomide) is the S-enantiomer of Thalidomide. (S)-Thalidomide has immunomodulatory, anti-inflammatory, antiangiogenic and pro-apoptotic effects[1][2][3]. (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN) [4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-(-)-Thalidomide. CAS No. 841-67-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14658A. | |
| (S)-Thalidomide 4-fluoride | (S)-Thalidomide 4-fluoride is a CRBN E3 ligase ligand that can be used for synthesis of DeDPP4 (HY-182336). Uses: Scientific research. Category: Signaling pathways. CAS No. 911109-85-8. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-W763812. | |
| (S)-Thalidomide-4-OH | (S)-Thalidomide-4-OH is the S-isomer of Thalidomide-4-OH (HY-103596). Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2357105-36-1. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg. Product ID: HY-W674436. | |
| Stigmasta-3,5-dien-7-one | Stigmasta-3,5-dien-7-one is a steroid compound that can be isolated from Harrisonia abyssinica. Stigmasta-3,5-dien-7-one blocks the NF-κB signaling pathway via down-regulation of phospho-p38 mitogen-activated protein kinase and phosphorylation and degradation of inhibitor of NF-κB α. Stigmasta-3,5-dien-7-one reduces LPS (HY-D1056)-induced nitric oxide, PGE2, and pro-inflammatory cytokine levels in macrophages. Stigmasta-3,5-dien-7-one can be used for inflammation diseases[1][2][3]. Uses: Scientific research. Category: Natural products. CAS No. 2034-72-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N12188. | |
| Stigmastan-3β-ol | Stigmastan-3β-ol is a sterol that can be isolated from Tinospora sinensis and Ginkgo biloba L. Stigmastan-3β-ol has antimicrobial activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 19466-47-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-144513. | |
| Stigmasterol | Stigmasterol is an orally acitve, immunomodulatory agent with anti-inflammatory and neuroprotective effect, as well as able to cross the blood-brain barrier. Stigmasterol activates AMPK, which in turn inhibits NF-κB and NLRP3 signaling pathways, reduces microglia-mediated neuroinflammation, and alleviates cognitive impairment and Alzheimer's disease. Stigmasterol regulates M1/M2 polarization of microglia through the TLR4/ NF-κB pathway, thereby reducing neuropathic pain. Stigmasterol can be used for neurodegenerative diseases, inflammatory diseases, and pain management, among others[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 83-48-7. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-N0131. | |
| Stigmasterol glucoside | Stigmasterol glucoside is a sterol compound and a 5α-reductase inhibitor with an IC50 value of 27.2 μM. Stigmasterol glucoside has certain anti-inflammatory, antioxidant, and anti-tumor activities[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 19716-26-8. Pack Sizes: 1 mg. Product ID: HY-N1200. | |
| Stigmasterol (Standard) | Stigmasterol (Standard) is the analytical standard of Stigmasterol (HY-N0131). This product is intended for research and analytical applications. Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Stigmasterin (Standard). CAS No. 83-48-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0131R. | |
| (S)-Timolol maleate | (S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-L-714,465 maleate; MK 950. CAS No. 26921-17-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg. Product ID: HY-17380. | |
| STING agonist-1 | STING agonist-1 (G10) is human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses. G10 potently blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: G10. CAS No. 702662-50-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19711. | |
| STING agonist-12 | STING agonist-12 (Compound 53) is a potent, orally active human STING activator with an EC50 of 185 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2259624-71-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147010. | |
| STING agonist-20 | STING agonist-20 (compound 95) is a potent STING agonist used in the synthesis of XMT-2056. STING agonist-20 can be used as a vaccine adjuvant in the study of cancer and other inflammatory, immune diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2591300-72-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148068. | |
| STING agonist-22 | STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2408723-12-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152955. | |
| STING agonist-3 | STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2138299-29-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103665. | |
| STING agonist-4 | STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2138300-40-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-123943. | |
| STING antagonist-1 | STING antagonist-1 is an antagonist of STING with an IC50 of 3.8 nM. STING antagonist-1 can be used in the research of autoimmune diseases, inflammatory diseases, and others[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3036981-21-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162664. | |
| STING-IN-2 | STING-IN-2 (C-170) is a potent and covalent STING inhibitor. STING-IN-2 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). STING-IN-2 can be used for autoinflammatory disease research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 346691-38-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138682. | |
| STING ligand-1 | STING ligand-1 is a lead STING ligand with an IC50 of 68 nM for HAQ STING[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2365039-41-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114399. | |
| Stiripentol | Stiripentol (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediatated by CYP3A4 (noncompetitively) and CYP2C19 (competitively) with Ki of 1.59±0.07 and 0.516±0.065 μM and IC50 of 1.58 and 3.29 μM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BCX2600. CAS No. 49763-96-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-103392. | |
| STL001 | STL001 is potent and selective FOXM1 inhibitor. STL001 induces the translocation of nuclear FOXM1 to the cytoplasm and promotes its autophagic degradation. STL001 sensitizes human cancers to a broad-spectrum of cancer therapies[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3047493-70-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158420. | |
| STL1267 | STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 μM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1429024-58-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148711. | |
| STL127705 | STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor with an IC50 of 3.5 μM. STL127705 interferes the binding of Ku70/80 to DNA and by inhibits the activation of the DNA-PKCS kinase. STL127705 shows antiproliferative and anticancer activity. STL127705 induces apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1326852-06-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122727. | |
| STM2457 | STM2457 is a first-in-class, highly potent, selective and orally active METTL3 inhibitor with an IC50 of 16.9 nM. STM2457 can be used for the research of acute myeloid leukaemia (AML)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2499663-01-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134836. | |
| STM3006 | STM3006 is a highly potent, selective, and orally active inhibitor of METTL3 (IC50: 5 nM). STM3006 can reduce the m6A level, promote the formation of dsRNA, trigger a cell-intrinsic interferon response, and enhance the killing effect of T cells on tumors. STM3006 has anti-tumor activity, and its combination with anti-PD-1 immunotherapy yields better results[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2499664-52-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156773. | |
| (S)-TNG260 | (S)-TNG260 is an isomer of TNG260 (HY-153358). TNG260 is a CoREST selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 causes HDAC1 inhibition and reverses anti-PD1 resistance driven by STK11 deletion. TNG260 reduces intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing. Uses: Scientific research. Category: Signaling pathways. CAS No. 2935964-93-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153358A. | |
| STO-609 | STO-609 is a selective and cell-permeable inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC50 ~0.02 g/ml. Uses: Scientific research. Category: Signaling pathways. CAS No. 52029-86-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19805. | |
| Streptavidin | Streptavidin is a ~60 kDa homotetramer. Streptavidin binds four molecules of biotin with the highest affinity. The binding affinity of biotin to streptavidin is one of the highest reported for a non-covalent interaction to date, with a KD ~0.01 pM[1]. Streptavidin has an immunosuppressive role[2]. This product is a Streptavidin protein recombinantly expressed in an E. coli expression system. Uses: Scientific research. Category: Signaling pathways. CAS No. 9013-20-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P3152. | |
| Streptokinase, β-hemolytic streptococcus (Lancefield Group C) | Streptokinase, β-hemolytic streptococcus (Lancefield Group C) is a bacteria-derived protein and a plasminogen activator. Streptokinase is widely used for the research of the blood-clotting disorders. Streptokinase improves reperfusion blood flow after coronary artery occlusion[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9002-1-1. Pack Sizes: 10 KU. Product ID: HY-P2824. | |
| Streptolysin O (≥1000000 units/mg) | Streptolysin O (≥1000000 units/mg) is a ≥1000000 units/mg Streptolysin O (HY-135416). Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 98072-47-0. Pack Sizes: 100 KU. Product ID: HY-135416A. | |
| Streptomycin | Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes [1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Agrept; Agrimycin; Streptomycin A. CAS No. 57-92-1. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B1906. | |
| Streptomycin sulfate | Streptomycin sulfate is an aminoglycoside antibiotic, that inhibits protein synthesis. Uses: Scientific research. Category: Signaling pathways. CAS No. 3810-74-0. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 10 g; 50 g. Product ID: HY-B0472. | |
| Streptonigrin | Streptonigrin (Bruneomycin) is an orally active antibiotic and pan-PAD inhibitor, inhibiting PAD1, PAD2, PAD3 and PAD4 with IC50 of 48.3 μM, 26.1 μM, 0.43 μM and 2.5 μM, respectively. Streptonigrin inhibits SENP1 (IC50 of 0.518 μM) and reduces HIF1α. Streptonigrin increases p53 and Apoptosis. Streptonigrin shows antiviral activity against Rauscher murine leukemia virus. Streptonigrin has immunosuppressive effects. Streptonigrin has antitumor activity against osteosarcoma[1][2][3][4][5][6][7][8][9][10]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Bruneomycin. CAS No. 3930-19-6. Pack Sizes: 500 μg; 1 mg. Product ID: HY-124586. | |
| Streptozotocin | Streptozotocin (Streptozocin; STZ) is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA ( DNA-methylating ). Streptozotocin can induce the apoptosis of β cells[1][2][3]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Streptozocin; NSC-85998; U 9889. CAS No. 18883-66-4. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-13753. | |
| S-Trityl-L-cysteine | S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC50 of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 83265; S-Tritylcysteine; 3-Tritylthio-L-alanine. CAS No. 2799-7-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-W011102. | |
| Strontium Ranelate | Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Distrontium renelate; S12911. CAS No. 135459-87-9. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-17397. | |
| Strophanthidin | Strophanthidin is a naturally available cardiac glycoside[1]. Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal[2]. Strophanthidin increases both diastolic and systolic intracellular Ca2+ concentration[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 66-28-4. Pack Sizes: 10 mM * 1 mL in Ethanol; 5 mg; 10 mg; 25 mg. Product ID: HY-114252. | |
| (S)-TROX-1 | (S)-TROX-1 is the S-enantiomer of TROX-1 (HY-120751). TROX-1 is a selective, orally active and brain-penetrant N-type calcium channel (Cav2.2) inhibitor with an IC50 value of 0.11 μM. TROX-1 exerts state-dependent and use-dependent inhibition, preferentially targets open/inactivated channels, blocks depolarization-associated calcium influx, and fully blocks calcium influx in rat dorsal root ganglion neurons. TROX-1 reverses inflammatory-induced hyperalgesia, nerve injury-induced allodynia. TROX-1 can be used for the research of pain[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2751591-42-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120751A. | |
| STS-E412 | STS-E412 is a selective activator of tissue-protective EPO receptor (including EPOR and CD131). STS-E412 can be used for research of neurodegenerative diseases and organ protection[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1609980-39-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W062700. | |
| STT3A/B-IN-1 | STT3A/B-IN-1 is an orally active STT3A/B inhibitor with antiviral activity. STT3A/B-IN-1 upregulates DERL3 gene expression levels. STT3A/B-IN-1 is promising for research of viral diseases, including cancer and neurodegenerative disorders[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3067184-99-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-169003. | |
| STX-0119 | STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 851095-32-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103692. | |
| STX-100 | STX-100 (BG00011) is a humanized monoclonal antibody targeting αVβ6 integrin. STX-100 specifically binds αVβ6 integrin, blocks latent TGF-β activation via latency-associated peptide (LAP) interaction prevention, and reduces profibrotic responses. STX-100 can be used for the research of idiopathic pulmonary fibrosis, and cancer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BG00011. CAS No. 1439902-67-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P990667. | |
| STX-721 | STX-721 is an orally active, irreversible, covalent EGFR exon 20 insertion (ex20ins) inhibitor that selectively targets ex20ins-mutant dynamic protein states. STX-721 potently inhibits the kinase activity of EGFR ex20ins mutants (NPG, ASV, SVD). STX-721 inhibits phosphorylation of EGFR (pEGFR Y1068) and downstream ERK (pERK Thr202/Tyr204), and suppresses proliferation of ex20ins-mutant Ba/F3 cells and human NSCLC cell lines (NCI-H2073 ASV KI, CUTO-14 ASV). STX-721 induces tumor regression in EGFR ex20ins-mutant PDX/CDX models. STX-721 can be used for the study of non-small cell lung cancer (NSCLC) harboring EGFR or HER2 ex20ins mutations[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2765525-82-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157229. | |
| SU0268 | SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1). SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2210228-45-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139056. | |
| SU056 | SU056 is a YB-1 inhibitor. SU056 induces cell-cycle arrest, apoptosis, and inhibits cell migration in ovarian cancer cells. SU056 interacts with YB-1 and inhibits and its associated downstream proteins and pathways. SU056 can enhance the cytotoxic effects of Paclitaxel (HY-B0015)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2376580-08-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150231. | |
| SU 10603 | SU 10603 is a specific inhibitor of P45017α (P450c17; CYP17A1)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 786-97-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116643. | |
| SU11274 | SU11274 is a selective Met inhibitor with IC50 of 10 nM, but has no effects on PGDFRβ, EGFR or Tie2. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PKI-SU11274. CAS No. 658084-23-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12014. | |
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