MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Sepimostat | Sepimostat (FUT-187 free base) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat inhibits the Ifenprodil binding with a Ki value of 27.7?μM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: FUT-187 free base. CAS No. 103926-64-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136299. |  |
| (-)-(S)-Equol | (-)-(S)-Equol is a high affinity ligand for estrogen receptor β with a Ki of 0.73 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 531-95-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100583. | |
| Serabelisib | Serabelisib (MLN1117) is a selective p110α inhibitor with an IC50 of 15 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MLN1117; INK1117; TAK-117. CAS No. 1268454-23-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12285. | |
| (Ser(Ac)3)-Ghrelin (mouse, rat) | (Ser(Ac)3)-Ghrelin (mouse, rat) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development[1]. Uses: Scientific research. Category: Peptides. CAS No. 321974-76-9. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-P4687. | |
| Seralutinib | Seralutinib (GB002) is an inhaled PDGFRα and PDGFRβ inhibitor. Seralutinib also targets to CSF1R and c-KIT with IC50s of 8 nM and 14 nM, respectively. Seralutinib (GB002) is used in the study for pulmonary arterial hypertension[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GB002; PK10571. CAS No. 1619931-27-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109190. | |
| SerBut | SerBut is a serine conjugated butyrate prodrug with oral activity. SerBut has anti-inflammatory activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 63321-66-4. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-162448. | |
| Serclutamab | Serclutamab is a humanized chimeric antibody targeting EGFR IgG1-κ. Mainly expressed by CHO (Chinese Hamster Ovary) cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PR-1594407; DC-1630423. CAS No. 2140172-41-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99892. | |
| Seribantumab | Seribantumab (MM 121) is a fully human IgG2 monoclonal antibody that targets HER3. Seribantumab blocks the activation of epidermal growth factor receptor (ErbB) family members and its downstream signal. Seribantumab inhibits neuregulin 1 (NRG1) fusion-dependent tumorigenesis in vitro and in vivo in breast, lung and ovarian patient-derived cancer models[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SAR 256212; MM 121. CAS No. 1334296-12-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99268. | |
| Sericoside | Sericoside is a triterpenoid with anti-inflammatory activity, can be isolated form Terminalia. Sericoside has a strong lipolytic activity. Sericoside can also reduce skin wrinkles and ameliorating skin texture[1][2][3]. Uses: Scientific research. Category: Natural products. CAS No. 55306-04-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N10496. | |
| Serotonin | Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5-Hydroxytryptamine; 5-HT. CAS No. 50-67-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1473A. | |
| Serotonin-d4 | Serotonin-d4 is deuterium labeled Serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5-Hydroxytryptamine-d4; 5-HT-d4. CAS No. 58264-95-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-B1473AS. | |
| Serotonin-d4 hydrochloride | Serotonin-d4 (5-Hydroxytryptamine-d4) hydrochloride is the deuterium labeled Serotonin (hydrochloride) (HY-B1473)[1]. Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5-Hydroxytryptamine-d4 hydrochloride; 5-HT-d4 hydrochloride. CAS No. 2469263-61-2. Pack Sizes: 1 mg. Product ID: HY-B1473S. | |
| Serotonin hydrochloride | Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist, with blood-brain barrier permeability. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5-Hydroxytryptamine hydrochloride; 5-HT hydrochloride. CAS No. 153-98-0. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg. Product ID: HY-B1473. | |
| Serotonin hydrochloride (Standard) | Serotonin (5-Hydroxytryptamine) (Standard) hydrochloride is the analytical standard of Serotonin hydrochloride (HY-B1473). This product is intended for research and analytical applications. Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5-Hydroxytryptamine hydrochloride (Standard); 5-HT hydrochloride (Standard). CAS No. 153-98-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1473R. | |
| Serpin B9-IN-1 | Serpin B9-IN-1 (BTCA) is an inhibitor that specifically targets Serpin B9 (SB9); SB9 is a natural inhibitor of granzyme B (GrB) , but may promote the metastasis of lung cancer cells into the bone marrow. SB9-overexpressing cancer cells promote proliferation and metastasis in an immune cell-dependent manner by binding to GrB. Inhibition of SB9 by Serpin B9-IN-1 significantly inhibits immunotherapy of lung cancer bone metastases in the caudal artery (CA) mouse model (LCBM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BTCA. CAS No. 154235-77-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g. Product ID: HY-33299. | |
| Serpinin | Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the cAMP-PKA-Sp1 signaling pathway, promoting granule biogenesis in endocrine cells. Serpinin is used in research related to the regulation of secretory function[1]. Serpinin is a selective agonist for β-adrenergic receptors. Serpinin interacts with β1-adrenergic receptors to activate the AC-cAMP-PKA pathway, which regulates myocardial systolic and diastolic function. pGlu-serpinin upregulates Bcl2 mRNA transcription and exerts neuroprotective effects[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1383743-23-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10336. | |
| Sertindole | Sertindole (Lu 23-174) is an orally active 5-HT2A, 5-HT2C, dopamine D2, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Lu 23-174. CAS No. 106516-24-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14543. | |
| Sertraline hydrochloride | Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 79559-97-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-B0176A. | |
| Sertraline hydrochloride (Standard) | Sertraline (hydrochloride) (Standard) is the analytical standard of Sertraline (hydrochloride). This product is intended for research and analytical applications. Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 79559-97-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0176AR. | |
| Serum thymic factor | Serum thymic factor (Thymulin) is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Thymulin; Thymic factor. CAS No. 63958-90-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3206. | |
| Serum thymic factor acetate | Serum thymic factor acetate (Thymulin acetate) is the acetate salt form of Serum thymic factor (HY-P3206). Serum thymic factor acetate is a zinc-dependent immunomodulatory peptide hormone, which can be produced by the thymic epithelial cells. Serum thymic factor acetate stimulates the release of hormones from the pituitary gland, exhibits hypophysiotropic activity. Serum thymic factor acetate protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor acetate exhibits anti-diabetic, anti-inflammatory and analgesic effects. Serum thymic factor acetate can be used in research about endocrine, reproductive, neurodegenerative and inflammatory diseases[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Thymulin acetate; Thymic factor acetate. CAS No. 125117-65-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3206A. | |
| Serylleucine | Serylleucine (H-Ser-Leu-OH) is a dipeptide. Serylleucine's core 1 o-glycosylated peptide (SLC1G) can be detected in urine as a metabolite and is a biomarker in TB studies[1]. Uses: Scientific research. Category: Peptides. Alternative Names: H-Ser-Leu-OH; Ser-Leu. CAS No. 6665-16-3. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P4511. | |
| Sesame Oil | Sesame Oil is a vegetable oil. Sesame Oil can be extracted from the seeds of Sesamum indicum L. Sesame Oil decreases NF-κB, aspartate aminotransferase, alanine aminotransferase, IL-1β, IL-4 and nitric oxide. Sesame Oil has antitumor activity against malignant melanoma. Sesame Oil has protective effects against liver damage caused by various agents such as Cisplatin (HY-17394) and Acetaminophen (HY-66005). Sesame Oil shows antinociceptive and anti-inflammatory activities[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. CAS No. 8008-74-0. Pack Sizes: 50 mL; 100 mL. Product ID: HY-154629. | |
| Sesamin | Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 607-80-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0121. | |
| SET2 | SET2 is a selective TRPV2 antagonist (IC50=0.46 μM). SET2 blocks the TRP channel and suppresses prostate cancer cells migration. SET2 reduces the lysophosphatidic acid (LPA, a TRPV2 activator)-induced cytoplasmic calcium increases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2313525-20-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132222. | |
| Setanaxib | Setanaxib (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GKT137831; GKT831. CAS No. 1218942-37-0. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-12298. | |
| SETDB1-TTD-IN-1 | SETDB1-TTD-IN-1 is a SETDB1 methyltransferase activator and SETDB1-TTD competitive inhibitor (Kd of 88 nM), and selectivity for SETDB1-TTD over other tudor and bromodomain proteins. SETDB1-TTD-IN-1 stimulates methyltransferase activity via increased catalytic activity, promotes Akt1 Lys64 methylation, Akt1 Thr308 phosphorylation and activation. SETDB1-TTD-IN-1 prevents SETDB1-TTD-histone H3 peptide association, induces global gene expression changes, exhibits cellular target engagement, and acts as a tool compound for SETDB1-TTD function exploration. SETDB1-TTD-IN-1 can be used for the research of breast cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2755823-12-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141539. | |
| (S)-Ethyl lactate | (S)-Ethyl lactate ((S)-(-)-ethyl lactate) is a volatile compound produced by plant fermentation. (S)-Ethyl lactate cansynergistically attracts palm weevils with specific pheromones and is mainly used for pest monitoring and control research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 687-47-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 g; 1 k g. Product ID: HY-W038795. | |
| Setidegrasib | Setidegrasib (KRAS G12D inhibitor 17, ASP3082) is a PROTAC KRAS degrader (DC50: 37 nM). Setidegrasib induces the degradation of G12D-mutation KRAS protein. Setidegrasib suppresses p-ERK, p-AKT, p-S6 levels in AsPC-1 cells. Setidegrasib exhibits anti-tumor activity in various cancer xenograft models in mice. Setidegrasib can be used for the study of KRAS(G12D)-mutated solid tumors. (Blue: VHL ligase ligand (HY-168699); Black: linker (HY-168698); Pink: G12D ligand (HY-168700))[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ASP-3082; KRAS G12D inhibitor 17. CAS No. 2821793-99-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148273. | |
| Setiptiline | Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Org-8282. CAS No. 57262-94-9. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-32329. | |
| Setmelanotide | Setmelanotide (RM-493) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RM-493; BIM-22493; IRC-022493. CAS No. 920014-72-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19870. | |
| Setmelanotide monoacetate | Setmelanotide monoacetate (RM-493 monoacetate) is a blood-brain barrier-permeable, selective MC4R agonist with a Ki value of 2.1 nM for hMC4R. Setmelanotide monoacetate activates the CaMKK2/AMPK signaling pathway. Setmelanotide monoacetate mediates body weight homeostasis, feeding regulation and energy expenditure modulation; it reduces food intake, induces weight loss, decreases obesity severity, increases daytime activity and energy expenditure, lowers levels of leptin, triglycerides, fasting insulin and diastolic blood pressure, improves insulin sensitivity, glucose tolerance and fatty liver condition, and reverses respiratory depression. Setmelanotide monoacetate is applicable to research related to obesity, hyperinsulinemia, fatty liver and respiratory depression[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RM-493 monoacetate; BIM-22493 monoacetate; IRC-022493 monoacetate. CAS No. 2759937-80-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-19870C. | |
| Setrobuvir | Setrobuvir (ANA598) is an orally active non-nucleosidic HCV NS5B polymerase inhibitor. ANA-598 inhibits both de novo RNA synthesis and primer extension, with IC50s between 4 and 5 nM. Setrobuvir also shows excellent binding affinity to SARS-CoV-2 RdRp and induces RdRp inhibition[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ANA598. CAS No. 1071517-39-9. Pack Sizes: 1 mg. Product ID: HY-13247. | |
| Setrusumab | Setrusumab (BPS 804) is a fully human monoclonal antibody targets sclerostin. Setrusumab efftively improves bone strength. Setrusumab can be used for the resesrch of Osteogenesis Imperfecta (OI) and cancer[1]. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: BPS 804. CAS No. 1847394-95-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99398. | |
| Sevabertinib | Sevabertinib (BAY 2927088) is an orally active and reversible dual EGFR-HER2 inhibitor (IC50 <0.5 nM for wild-type HER2, HER2 A775insYVMA, wild-type EGFR, and EGFR D770_N771insSVD). Sevabertinib has anticancer activity against lung cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 2927088. CAS No. 2521285-05-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 1 g. Product ID: HY-164718. | |
| Sevasemten | Sevasemten is an orally active, selective allosteric inhibitor of skeletal muscle myosin that protects skeletal muscle from contraction-induced injury. Sevasemten decreases muscle damage biomarkers and fibrosis while increasing muscle strength and activity in in Duchenne muscular dystrophy disease models[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EDG-5506. CAS No. 2417395-15-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148799. | |
| Sevirumab | Sevirumab (MSL-109) is a human IgG1 neutralizing monoclonal antibody against cytomegalovirus (CMV). Sevirumab recognizes CMV gH complexes and inhibits CMV replication with an EC50 of 0.3 μg/mL[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MSL-109. CAS No. 138660-96-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P99900. | |
| Seviteronel | Seviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) and an AR antagonist. Seviteronel demonstrates both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VT-464. CAS No. 1610537-15-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15996. | |
| Seviteronel (R enantiomer) | Seviteronel R enantiomer (VT-464 R enantiomer) is the R enantiomer of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM); Seviteronel (VT-464) R enantiomer's activity is unknown. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VT-464 (R enantiomer). CAS No. 1375603-38-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15996A. | |
| SEW?2871 | SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimers disease, liver fibrosis, and inflammatory responses[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 256414-75-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-W008947. | |
| SF1670 | SF1670 is a potent and specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 345630-40-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-15842. | |
| SF2312 | SF2312, a natural phosphonate antibiotic (Antibiotic), is a highly potent Enolase inhibitor with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 107729-45-3. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117778. | |
| (S)-Fluoxetine hydrochloride | (S)-Fluoxetine hydrochloride, an antidepressant, is serotonin reuptake inhibitor (SSRI)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 114247-06-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-B0102B. | |
| SFTI-1 | SFTI-1 is a cyclic peptide trypsin inhibitor consisting of 14 amino acid residues. SFTI-1 belongs to the Bowman-Birk class of inhibitors. Characterized by its small size, high stability, and potent activity, SFTI-1 can be used for research on peptide drug design platforms[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 245080-24-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10033. | |
| SG-094 | SG-094 is a potent TPC2 inhibitor with antiproliferative effects. SG-094 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2922283-37-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148816. | |
| SG2057 | SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DRG16. CAS No. 260417-62-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-101160. | |
| SG3199 | SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1595275-71-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-101161. | |
| SGA360 | SGA360 suppress inflammatory SAA1 signaling in an AHR-dependent manner through a mechanism that does not require AHR binding to its cognate response element (partial antagonist)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 680611-86-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122208. | |
| SGC0946 | SGC0946 is a selective DOT1L inhibitor with an IC50 value of 0.3 nM. By inhibiting DOT1L, SGC0946 can induce G1 phase arrest, suppress cell self-renewal and metastatic potential, and induce cell differentiation in cancer cells. SGC0946 can be used in the research of tumors such as leukemia and breast cancer, and also serves as a probe to further investigate the cellular mechanisms of DOT1L in normal and diseased cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1561178-17-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15650. | |
| SGC3027 | SGC3027 is a histone methyltransferase inhibitor[1]. SGC3027 is the first potent, selective and cell active chemical probe for PRMT7[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2624313-13-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112445. | |
| SGC707 | SGC707, a chemical probe, is a potent, selective, and non-competitive PRMT3 (protein arginine methyltransferase 3) inhibitor (IC50=31 nM, Kd=53 nM). Uses: Scientific research. Category: Signaling pathways. CAS No. 1687736-54-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-19715. | |
| SGC8158 | SGC8158 is an inhibitor of PRMT7 and can be used to study the cellular function of PRMT7. SGC8158 decreases monomethylarginine levels of Hsp70 (the best characterized PRMT7 substrate). SGC8158 induces growth inhibition in various cancer cells (IC50: 2-9 μM), as well as multidrug-resistant (MDR) cancer cells. SGC8158 also enhances Doxorubicin (HY-15142A) induced DNA damage and Its cytotoxicity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3062376-84-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-114211. | |
| SGC-AAK1-1 | SGC-AAK1-1, a chemical probe, is a potent and selective AAK1 (AP2 associated kinase 1) inhibitor with an IC50 of 270 nM and a Ki of 9 nM. SGC-AAK1-1 also potently inhibits BMP2K. SGC-AAK1-1 is used to study Wnt pathway related to AAK1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2247894-32-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123940. | |
| SGC-CAMKK2-1 | SGC-CAMKK2-1, a chemical probe, is the selective, inhibitor for calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) with an IC50 of 30 nM. SGC-CAMKK2-1 inhibits AMPK phosphorylation in cell C4-2 with an IC50 of 1.6 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2561494-76-4. Pack Sizes: 5 mg. Product ID: HY-168905. | |
| SGC-CBP30 | SGC-CBP30, a chemical probe, is a potent and highly selective CBP/p300 bromodomain (Kds of 21 nM and 32 nM for CBP and p300, respectively) inhibitor, displaying 40-fold selectivity over the first bromodomain of BRD4 [BRD4(1)] bound. SGC-CBP30 strongly reduces secretion of IL-17A in Th17 cells and has anti-inflammatory effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1613695-14-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15826. | |
| SGC-CDKL2/AAK1/BMP2K-1 | SGC-CDKL2/AAK1/BMP2K-1 (Compound 9) is a potent and selective CDKL2 (Cyclin-dependent kinase-like 2) inhibitor with an IC50 value of 460 nM. CDKL2 is involved in various biological processes such as tumorigenesis, development, and viral infections. SGC-CDKL2/AAK1/BMP2K-1 serves as a powerful tool for studying the biological functions of CDKL2 and holds promise for research in fields related to cancer, infections, and other diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2471972-15-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-162653. | |
| SGC-CK2-1 | SGC-CK2-1 is a highly potent, ATP-competitive, and cell-active CK2 chemical probe with exclusive selectivity for both human CK2 isoforms, with IC50s of 36 and 16 nM for CK2α and CK2αrespectively in the nanoBRET assay. SGC-CK2-1 can be used for the research of neurodegenerative diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2470424-39-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139004. | |
| SGC-CLK-1 | SGC-CLK-1, a chemical probe, is a potent and selective inhibitor of Cdc2-like kinases CLK1, CLK2, and CLK4. SGC-CLK-1 can inhibit the growth of melanoma and glioblastoma cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CAF-170. CAS No. 748142-15-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153708. | |
| SGC-GAK-1 | SGC-GAK-1 is a potent, selective cyclin G-associated kinase (GAK) inhibitor with a Ki of 3.1 nM. SGC-GAK-1 is a chemical probe for GAK[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2226517-76-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122186. | |
| SGC-iMLLT | SGC-iMLLT is a first-in-class chemical probe and a potent, selective inhibitor of MLLT1/3-histone interactions with an IC50 of 0.26 μM. SGC-iMLLT shows high binding activity towards MLLT1 YEATS domain (YD) and MLLT3 YD (AF9/YEATS3) with Kds of 0.129 and 0.077 μM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2255338-25-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112804. | |
| SGC-SMARCA-BRDVIII | SGC-SMARCA-BRDVIII, a chemical probe, is a potent and selective inhibitor of SMARCA2/4 and PB1(5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1(2) and PB1(3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1997319-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145446. | |
| SGC-STK17B-1 | SGC-STK17B-1, a chemical probe, is an ATP-competitive and selective STK17B (a member of DAPK family) inhibitor (IC50: 34 nM, KD: 5.6 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2650530-00-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-156350. | |
| SGD-1882 | SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PBD dimer. CAS No. 1222490-34-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-101127. | |
| SGF29-IN-1 | SGF29-IN-1 (Compound Cpd_DC60) is a selective inhibitor for Spt-Ada-Gcn5 acetyltransferase (SAGA)-associated factor 29 (SGF29)-Tudor domain. SGF29-IN-1 exhibits activity against leukemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6638-82-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158009. | |
| SGI-1027 | SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC50s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate. Uses: Scientific research. Category: Signaling pathways. CAS No. 1020149-73-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13962. | |
| SGI-1776 free base | SGI-1776 free base is an inhibitor of Pim kinases, with IC50s of 7 nM, 363 nM, and 69 nM for Pim-1, -2 and -3, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1025065-69-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13287. | |
| SGK1-IN-1 | SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1279829-87-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18607. | |
| SGK1-IN-4 | SGK1-IN-4 (compound 17a) is a highly selective, orally active SGK1 inhibitor. SGK1-IN-4 can be used for osteoarthritis research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1628048-93-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142687. | |
| SGN-2FF | SGN-2FF is a potent and orally active inhibitor of fucosylation, directly inhibits fucosyltransferase activity. SGN-2FF possesses antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2089647-47-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107366. | |
| (S)-GNE-140 | (S)-GNE-140 is the less active enantiomer of GNE-140 which can inhibit Lactate dehydrogenase A (LDHA). Uses: Scientific research. Category: Signaling pathways. CAS No. 2003234-64-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100742B. | |
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