MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Santalol | Santalol is a mixture of α and β-isomer santalol. α-Santalol is found in sandalwood oil. α-Santalol is a promising anti-cancer agent against cancers such as oral, breast, prostate and skin cancer. Santalol has sedative activity [1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 11031-45-1. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-N2059. |  |
| Sapablursen | Sapablursen, an antisense oligonucleotide, is designed to reduce the production of TMPRSS6 resulting in increased expression of hepcidin, which is the key regulator of iron homeostasis. Sapablursen can be used in the research of blood diseases such as pol. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IONIS-TMPRSS6-Lrx; ISIS 702843. CAS No. 2273007-95-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-177662. | |
| Sapacitabine | Sapacitabine is an orally available nucleoside analog proagent that is structurally related to cytarabine. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CS682; CYC682. CAS No. 151823-14-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16445. | |
| Sapanisertib | Sapanisertib (INK-128; MLN0128; TAK-228) is an orally available, ATP-dependent mTOR1/2 inhibitor with an IC50 of 1 nM for mTOR kinase. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INK-128; MLN0128; TAK-228. CAS No. 1224844-38-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13328. | |
| Sapienic acid sodium | Sapienic acid sodium is a fatty acid commonly found on the skin and in mucosa. Sapienic acid sodium has variable antimicrobial activities against Gram-positive and Gram-negative bacteria found on the skin and in the oral cavity. Sapienic acid sodium is active against Streptococcus sanguinis, Streptococcus mitis and Fusobacterium nucleatum with MBC values of 31.3 μg/mL, 375.0 μg/mL and 93.8 μg/mL, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 217477-25-3. Pack Sizes: 10 mM * 1 mL in Ethanol; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130187A. | |
| Sapitinib | Sapitinib (AZD-8931) is a reversible, ATP competitive EGFR inhibitor of with IC50s of 4, 3 and 4 nM for EGFR, ErbB2 and ErbB3 in cells, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD-8931. CAS No. 848942-61-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13050. | |
| Saponarin | Saponarin is an orally active flavonoid compound. Saponarin can be isolated from Gypsophila trichotoma. Saponarin inhibits ERK/p38, NF-κB and MAPK phosphorylation and activates AMPK. Saponarin reduces IL-1β and COX-2. Saponarin has antioxidant, anti-inflammatory, hepatoprotective, hypoglycemic and hypotensive effects. Saponarin improves sleep disorders[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 20310-89-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N5083. | |
| Saponins | Saponins (Saponin) is a class of chemical compound of glycosides found in particular abundance in various plant species. In plants, Saponins may serve as anti-feedants, and to protect the plant against microbes and fungi[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Saponin. CAS No. 8047-15-2. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-100597. | |
| Sappanone A | Sappanone A is an orally active homoisoflavone found in sappan L. Sappanone A is a PDE4 and NF-κB inhibitor with anti-inflammatory and antioxidant effect. Sappanone A induces HO-1 expression through activation of Nrf2 pathway. Sappanone A also inhibits RANKL-induced osteoclastogenesis. Sappanone A has great potential in the research of inflammation-related and cardiovascular[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 102067-84-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-113556. | |
| Sapropterin dihydrochloride | Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride. CAS No. 69056-38-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0124A. | |
| Saquinavir | Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ro 31-8959. CAS No. 127779-20-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17007. | |
| Saquinavir mesylate | Saquinavir (Ro 31-8959) mesylate is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir mesylate also has anti-inflammatory activity and can induce apoptosis of human red blood cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ro 31-8959/003. CAS No. 149845-06-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17003. | |
| SAR131675 | SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM. SAR131675 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1433953-83-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15458. | |
| (Sar1,Ile4,8)-Angiotensin II | (Sar1,Ile4,8)-Angiotensin II is a functionally selective angiotensin II type 1 receptor (AT1R) agonist. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated insulin receptor (IR) signaling and glycogen synthesis. (Sar1,Ile4,8)-Angiotensin II potentiates insulin-stimulated phosphorylation of Akt and GSK3α/β[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 185461-45-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P4685. | |
| SAR247799 | SAR247799 (S1P1 agonist 3) is an oral activity, selective G-protein-biased sphingosine-1 phosphate receptor-1 (S1P1 ) agonist, with EC50s rang from 12.6 to 493 nM in S1P1-overexpressing cells and HUVECs. SAR247799 can be used for the research of endothelial protection, including type-2 diabetes, metabolic syndrome[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: S1P1 agonist 3. CAS No. 1315311-14-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115831. | |
| SAR405 | SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM). SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition. Anticancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1523406-39-4. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12481. | |
| SAR407899 | SAR407899 is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively. SAR407899 shows stable inhibition of migrasome formation. Uses: Scientific research. Category: Signaling pathways. CAS No. 923359-38-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15687A. | |
| SAR502250 | SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimers disease (AD)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 503860-57-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137472. | |
| SAR629 | SAR629 is a potent monoglyceride lipase (MGL) covalent inhibitor. SAR629 also inhibits 2-Arachidonoylglycerol (2-AG) degradation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1221418-42-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118653. | |
| SAR7334 | SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1333210-07-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15699. | |
| SAR7334 hydrochloride | SAR7334 hydrochloride is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1333207-63-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15699A. | |
| Saracatinib | Saracatinib (AZD0530) is a potent Src family inhibitor with IC50s of 2.7 to 11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr, and Blk. Saracatinib shows high selectivity over other tyrosine kinases[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD0530. CAS No. 379231-04-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10234. | |
| Saracatinib difumarate | Saracatinib (AZD0530) difumarate is a potent Src inhibitor with IC50 values of 2.7-11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr and Blk, and is selective for other tyrosine kinases. [1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD0530 difumarate. CAS No. 893428-72-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10234A. | |
| Sarafloxacin hydrochloride | Sarafloxacin hydrochloride (A-56620 hydrochloride) is a fluoroquinolone Antibacterial agent. Sarafloxacin inhibits the growth of Staphylococcus aureus, Enterobacteriaceae, and both aminoglycoside-sensitive and aminoglycoside-resistant strains of Pseudomonas aeruginosa[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: A-56620 hydrochloride. CAS No. 91296-87-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0343A. | |
| Sarcosine oxidase, Bacillus | Sarcosine oxidase, Bacillus (SAO) can catalyze the oxidative demethylation of sarcosine to generate glycine, H2O2, 5,10-CH2-tetrahydrofolate, which are often used in biochemical reactions[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SAO. CAS No. 9029-22-5. Pack Sizes: 10 KU. Product ID: HY-P2861. | |
| Sarcosine (Standard) | Sarcosine (Standard) is the analytical standard of Sarcosine. This product is intended for research and analytical applications. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Methylglycine (Standard); Sarcosin (Standard). CAS No. 107-97-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101037R. | |
| Sardomozide | Sardomozide is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CGP 48664; SAM-486A. CAS No. 149400-88-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13746. | |
| Sardomozide dihydrochloride | Sardomozide dihydrochloride is an S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC50 of 5 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CGP 48664A. CAS No. 138794-73-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-13746B. | |
| Sar-[D-Phe8]-des-Arg9-Bradykinin | Sar-[D-Phe8]-des-Arg9-Bradykinin is a agonist of B1 receptor. Sar-[D-Phe8]-des-Arg9-Bradykinin selectively amplifies the contractile response when incubation with human recombinant interleukin-1 β (IL-1 β) in rabbit aortic rings[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 126959-88-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103291. | |
| Sarecycline hydrochloride | Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloride has anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: P-005672 hydrochloride. CAS No. 1035979-44-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-13858A. | |
| Saredutant | Saredutant is a selective NK2 receptor antagonist. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SR 48968; SR 48968C. CAS No. 142001-63-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106910. | |
| Saridegib | Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IPI-926; Patidegib. CAS No. 1037210-93-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-16587. | |
| Sarilumab | Sarilumab is a monoclonal antibody targeting IL6 that binds to IL6R and blocks the binding of IL6, thereby inhibiting the activation of the downstream STAT3 phosphorylation signaling pathway. In tumor cells with active IL6/STAT3 signaling pathways, Sarilumab induces Apoptosis and inhibits cell growth. Sarilumab is applicable to research related to prostate cancer, lung cancer and rheumatoid arthritis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-Human IL6Rα, Human Antibody. CAS No. 1189541-98-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9916. | |
| Sarizotan | Sarizotan (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EMD 128130. CAS No. 351862-32-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100820. | |
| SARM1-IN-2 | SARM1-IN-2 (Example 82) is a SARM1 inhibitor (IC50 <1 μM) that inhibits axon regeneration. Axon regeneration refers to the process by which neuronal axons attempt to restore their structure and function after axonal degeneration. SARM1-IN-2 inhibits axon regeneration by reducing or inhibiting the binding of SARM1 to NAD+. SARM1-IN-2 can be used to study axonal degeneration[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2396592-52-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145917. | |
| SARM1-IN-5 | SARM1-IN-5 (compound 1-23-a) is a SARM1 inhibitor. SARM1-IN-5 can be used in the study of axonal degeneration related diseases such as Alzheimers disease, Parkinsons disease, amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2762081-30-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-172967. | |
| SARM1-IN-9 | SARM1-IN-9 (Compound MY-13B) is a stereoselective SARM1 inhibitor. SARM1-IN-9 is applicable to research related to axon degeneration-dependent neurological diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3020765-69-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-182500. | |
| Saroglitazar | Saroglitazar is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 495399-09-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19937. | |
| Sarolaner | Sarolaner (PF-6450567) is an orally active and broad-spectrum ectoparasiticide. Sarolaner is an isoxazoline compound which shows efficacy against fleas and ticks on dogs, with a LC80 value of 0.3 μg/mL against C. felis and a LC100 value of 0.003 μg/mL against O. turicata[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-6450567. CAS No. 1398609-39-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16730. | |
| Sarsasapogenin | Sarsasapogenin is a sapogenin from the Chinese medical herb Anemarrhena asphodeloides Bunge, with antidiabetic, anti-oxidative, anticancer and anti-inflamatory activities. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Parigenin; Sarsagenin. CAS No. 126-19-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0073. | |
| SARS-CoV-2 nsp3-IN-1 | SARS-CoV-2 nsp3-IN-1 (Compound 15c) is a Mac1 (SARS-CoV-2 nsp3 macrodomain) inhibitor with the IC50 value of 6.1 μM. SARS-CoV-2 nsp3-IN-1 can inhibit Mac1 ADP-ribosylhydrolase activity. SARS-CoV-2 nsp3-IN-1 demonstrates notable selectivity for coronavirus macrodomains, especially towards SARS-CoV-2 Mac1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2892105-43-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-150062. | |
| Saruparib | Saruparib (AZD5305) is a potent, orally active and selective PARP inhibitor and trapper with IC50 values of 3 nM and 1400 nM for PARP1 and PARP2, respectively. Saruparib has anti-proliferative activity and inhibits growth in cells with deficiencies in DNA repair[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD5305. CAS No. 2589531-76-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132167. | |
| Sasanlimab | Sasanlimab is a humanized IgG4 isotype anti-PD-1 antibody. Sasanlimab blocks PD-1 interaction with PD-L1/PD-L2, reverses PD-1-mediated inhibitory T-cell signaling, augments T-cell proliferation and cytokine production. Sasanlimab inhibits colon adenocarcinoma tumor growth, and accelerates graft-versus-host disease incidence via enhanced T-cell activity. Sasanlimab can be used for the research of cancer, such as bladder cancer and colon adenocarcinoma[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-06801591. CAS No. 2206792-50-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99884. | |
| Satoreotide | Satoreotide (JR11) is a SSTR2 antagonist. Satoreotide is usually conjugated with radiolabeled chelators used in neuroendocrine tumor imaing[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JR11. CAS No. 1801415-23-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10137. | |
| Satralizumab | Satralizumab is a humanized monoclonal antibody that targets IL-6R. Satralizumab prevents dTAA formation and progression in rattus norvegicus. Satralizumab can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RG-6168; SA-237. CAS No. 1535963-91-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P99112. | |
| Satraplatin | Satraplatin is an alkylating agent, with potent antitumor effect. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS182751; BMY45594; JM216. CAS No. 129580-63-8. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17576. | |
| Satratoxin G | Satratoxin G is a large cyclic mucor toxin. Satratoxin G induces apoptosis by activation of caspase[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 53126-63-9. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-130476. | |
| Satratoxin H | Satratoxin H is a toxic metabolite of Stachybotrys atra. Satratoxin H induces caspase-3 and PARP cleavage via p38 MAPK and JNK pathways, stimulates JNK, ERK, and p38 MAPK phosphorylation, and activates JNK and p38 MAPK in a glutathione-sensitive manner. Satratoxin H induces DNA double-stranded breaks, apoptotic body formation, intracellular reactive oxygen species generation, and endoplasmic reticulum stress via ATF6, PERK, and RE1 pathways. Satratoxin H can be used for the research of central nervous system disorders and melanoma[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 53126-64-0. Pack Sizes: 500 μg. Product ID: HY-123647. | |
| Sauchinone | Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 177931-17-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0613. | |
| Savolitinib | Savolitinib (AZD-6094) is a potent, highly selective, and orally bioavailable c-Met inhibitor with IC50 s of 5 nM and 3 nM for c-Met and p-Met, respectively. Savolitinib (AZD-6094) selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. Antineoplastic activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Volitinib; HMPL-504; AZD-6094. CAS No. 1313725-88-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15959. | |
| Saxagliptin | Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-477118. CAS No. 361442-04-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10285. | |
| SB02024 | SB02024 is a potent and orally active VPS34 inhibitor. SB02024 inhibits Vps34 kinase activity. SB02024 induces CCL5 and CXCL10 via STAT1/IRF7. SB02024 shows anticancer activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2126737-28-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122891. | |
| SB1-G-187 | SB1-G-187 is a multi-target kinase PROTAC degrader with activity against various kinases including GCK, YES1, IRAK1 and LYN. SB1-G-187 induces degradation of target kinases via a p97-dependent pathway, and forms ternary complexes with CRBN and specific functional kinases. SB1-G-187 can be used in tumor-related research. (Pink: multi-target kinase ligand (HY-125142); Blue: CRBN ligand (HY-A0003); Black: linker)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2769753-18-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137342. | |
| SB-200646A | SB-200646A is the first selective 5-HT2B/2C over 5-HT2A receptor antagonist with pKi values of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646A is orally active and has electrophysiological and anxiolytic properties in vivo[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 143797-62-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103129. | |
| SB 202190 | SB 202190 is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 binds to the ATP pocket of the active recombinant human p38 kinase with a Kd of 38 nM. SB 202190 has anti-cancer activity and rescued memory deficits[1][2]. SB202190 induces autophagy[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 152121-30-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg. Product ID: HY-10295. | |
| SB 202190 hydrochloride | SB 202190 hydrochloride is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38 kinase with a Kd of 38 nM. SB 202190 hydrochloride has anti-cancer activity[1][2]. SB202190 hydrochloride induces autophagy[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 350228-36-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10295A. | |
| SB 202474 | SB 202474, a negative analog of SB203580. SB 202474, which has no ability to inhibit p38 MAPK activity and is widely used as a negative control compound in p38 MAPK studies, also suppressed melanin synthesis induction[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 172747-50-1. Pack Sizes: 1 mg. Product ID: HY-112367. | |
| SB 203580 sulfone | SB 203580 sulfone is an analog of p38 MAP kinase inhibitor SB 203580. SB 203580 sulfone inhibits the IL-1 production (IC50 of 0.2 μM in monocytes) and binds competitively with CSAID binding proteins (CSBP), inhibits it mediated stress response signaling with an IC50 of 0.03 μM. SB 203580 sulfone inhibits 5-LO with an IC50 value of 24 μM. SB 203580 sulfone can be used in the research of inflammatory diseases[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 152121-46-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112349. | |
| SB 204741 | SB 204741 is a selective and high affinity 5-HT2B antagonist with a pKi value of 7.1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 152239-46-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103153. | |
| SB 204990 | SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme. Uses: Scientific research. Category: Signaling pathways. CAS No. 154566-12-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16450. | |
| SB 206553 hydrochloride | SB 206553 hydrochloride is a high affinity, selective and orally active 5-HT2B / 5-HT2C receptor antagonist (rat 5-HT2B pA2 = 8.89, human 5-HT2C pKi = 7.92)[1]. SB 206553 possesses anxiolytic-like properties[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1197334-04-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-103135. | |
| SB 216763 | SB 216763 is potent, selective and ATP-competitive GSK-3 inhibitor with IC50s of 34.3 nM for both GSK-3α and GSK-3β. Uses: Scientific research. Category: Signaling pathways. CAS No. 280744-09-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12012. | |
| SB-218078 | SB-218078 is a potent, selective, ATP-competitive and cell-permeable checkpoint kinase 1 (Chk1) inhibitor that inhibits Chk1 phosphorylation of cdc25C with an IC50 of 15 nM. SB-218078 is less potently inhibits Cdc2 (IC50 of 250 nM) and PKC (IC50 of 1000 nM). SB-218078 causes apoptosis by DNA damage and cell cycle arrest[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 135897-06-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-107407. | |
| SB-222200 | SB-222200 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant NK-3 receptor antagonist. SB-222200 is developed for central nervous system (CNS) disorders[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 174635-69-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-15722. | |
| SB-224289 hydrochloride | SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SB-224289A. CAS No. 180084-26-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101105A. | |
| SB225002 | SB225002, a potent, selective and non-peptide CXCR2 antagonist, inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 182498-32-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 1 g. Product ID: HY-16711. | |
| SB 239063 | SB 239063 is a potent, selective and orally active p38 MAPK inhibitor, exhibits an IC50 of 44 nM for recombinant purified human p38α, with equipotent inhibitory activity against p38α and p38β. SB 239063 has no effect on p38γ or p38δ. With anti-asthma activity and also be used to enhance memory which is impaired due to aging or medical conditions, such as, AD. SB 239063 can penetrate the blood brain barrier (BBB)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 193551-21-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-11068. | |
| SB 242084 | SB 242084 is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 181632-25-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13409. | |
| SB 242084 dihydrochloride | SB 242084 dihydrochloride is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 dihydrochloride increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 dihydrochloride also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 dihydrochloride has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1049747-87-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13409A. | |
| SB 258719 | SB 258719 is a selective 5-HT7 receptor antagonist with high affinity (pKi=7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 195199-95-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00443. | |
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