MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| SGR-1505 | SGR-1505 is an oral small molecule MALT1 inhibitor with anti-proliferative and antitumor activity.SGR-1505 inhibits MALT1 enzymatic activity to modulate NF-κB pathway gene expression.SGR-1505 induces modulation of cell cycle, DNA damage, and apoptosis-related genes in in vivo tumor samples.SGR-1505 exerts tumorostatic and regressive activity in ABC-DLBCL xenograft models.SGR-1505 can be used for the research of activated B cell-like diffuse large B cell lymphoma, non-Hodgkin B-cell lymphomas, chronic lymphocytic leukemia, and mature B cell neoplasms[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2661481-41-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160698. |  |
| (S)-GSK-3685032 | (S)-GSK-3685032 is the isomer of GSK-3685032 (HY-139664), and can be used as an experimental control. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2170142-58-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139664B. | |
| SGX-523 | SGX523 is a exquisitely selective and ATP-competitive MET inhibitor. SGX523 potently inhibits MET with an IC50 of 4 nM and is >1,000-fold selective versus other protein kinases. Antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1022150-57-7. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12019. | |
| SH-42 | SH-42 is a potent and selective inhibitor of human Δ24-dehydrocholesterol reductase (DHCR24), with an IC50 of 42 nM. SH-42 can lead to a significant increase in plasma desmosterol levels of mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2143952-36-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143228. | |
| SH-4-54 | SH-4-54 is a CNS-penetrant STAT inhibitor that binds to STAT3 and STAT5 with KDs of 300, 464 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1456632-40-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-16975. | |
| SH514 | SH514 is an orally active IRF4 inhibitor (IC50 = 2.63 μM). SH514 binds to the IRF4-DBD domain, thereby inhibiting the interaction of IRF4 protein with DNA (KD = 1.28 μM). SH514 can inhibit the proliferation of IRF4-high-expressing NCI-H929 and MM.1R cells, and displays no cytotoxicity for normal cells. SH514 significantly downregulates the expression of IRF4 downstream target genes concentration-dependently. SH514 inhibits the expression of cell cycle-related proteins CDC2, Cyclin B1, Cyclin D1, Cyclin E1, and CMYC in Multiple Myeloma cells. SH514 can induce DNA damage and increase the expression of γH2AX. SH514 effectively inhibits the proliferation of multiple myeloma tumors [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3099543-90-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-172085. | |
| SH6 | SH6 is a transcription factor ZBTB7A degrader. SH6 is promising for research of β-hemoglobinopathies such as sickle cell disease (SCD) and β-thalassemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2619408-35-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-178486. | |
| SHA 68 | SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 847553-89-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108625. | |
| Shatavarin IV | Shatavarin IV is a steroidal saponin, that can be isolated from the roots of Asparagus racemosus (Liliaceae). Shatavarin IV shows anticancer activity. Shatavarin IV elicits lifespan extension and alleviates Parkinsonism in Caenorhabditis elegans[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Asparanin B. CAS No. 84633-34-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N8804. | |
| SH-BC-893 | SH-BC-893 is an orally active anti-neoplastic sphingolipid analog. SH-BC-893 also protects from ceramide-induced mitochondrial dysfunction and corrects diet-induced obesity. SH-BC-893 can be used for the research of cancer and obesity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1841409-92-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-124758. | |
| Shellac | Shellac is a biodegradable resin composed of polyhydroxy acids, primarily aleuritic acid, shellolic acid, and jalaric acid. It originates as a resinous secretion of the insect Kerria lacca, found on several species of trees in India, Thailand, and China. shellac is used as a wood coating, a binder and encapsulate for pharmaceuticals and food supplements, and in cosmetics products. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Shellac wax-free. CAS No. 9000-59-3. Pack Sizes: 100 g; 250 g. Product ID: HY-W133969. | |
| SHEN26 | SHEN26 (ATY014) is a potent and orally active RdRp inhibitor, with an IC50 for SARS-CoV-2 is 1.36 μM. SHEN26 is a 5-cyclohexanecarboxylate derivative of GS-441524 (HY-103586). SHEN26 inhibits viral nucleic acid synthesis to achieve antiviral effects. SHEN26 can be used for the research of coronavirus disease 2019 (COVID-19)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ATV014. CAS No. 2691076-98-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-155488. | |
| Shepherdine | Shepherdine, a harmala-type indole and tetrahydro-β-carboline alkaloid, is an antioxidant. Shepherdine scavenges free radicals via single electron transfer from its indole ring, forming an indolyl cation or neutral radical, and may convert to aromatic β-carbolines during this process. Shepherdine can be used for research on antioxidant activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3000-36-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N19254. | |
| Shield-1 | Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Shld1. CAS No. 914805-33-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112210. | |
| Shikonin | Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM[1]. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor[2] and can also inhibit TNF-α and NF-κB pathway[3]. Shikonin decreases exosome secretion through the inhibition of glycolysis[4]. Shikonin inhibits AIM2 inflammasome activation[7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: C.I. 75535; Isoarnebin 4. CAS No. 517-89-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0822. | |
| Shikonin (Standard) | Shikonin (Standard) is the analytical standard of Shikonin. This product is intended for research and analytical applications. Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM[1]. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor[2] and can also inhibit TNF-α and NF-κB pathway[3]. Shikonin decreases exosome secretion through the inhibition of glycolysis[4]. Shikonin inhibits AIM2 inflammasome activation[7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: C.I. 75535 (Standard); Isoarnebin 4 (Standard). CAS No. 517-89-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0822R. | |
| SHIN1 | SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RZ-2994. CAS No. 2146095-85-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112066. | |
| (-)-SHIN1 | (-)-SHIN1 ((-)-RZ-2994) is an inactive (-) enantiomer of SHIN1[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-RZ-2994. CAS No. 2444764-09-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112066B. | |
| (+)-SHIN1 | (+)-SHIN1 ((+)-RZ-2994) is an active (+) enantiomer of SHIN1[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-RZ-2994. CAS No. 2443966-90-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112066A. | |
| (+)SHIN2 | (+)SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor, whose target can be traced with 13C-serine. (+)SHIN2 increases survival in NOTCH1-driven mouse primary acute lymphoblastic leukemia (T-ALL) in vivo with a synergistic effect with Methotrexate (HY-14519)[1]. (+)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 3056942-19-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134978A. | |
| Shionone | Shionone is the major triterpenoid isolated from Aster tataricus, has anti-tussive, anti-inflammatory activities[1][2]. Shionone possesses a unique six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure[1]. Uses: Scientific research. Category: Natural products. CAS No. 10376-48-4. Pack Sizes: 5 mg; 10 mg; 20 mg. Product ID: HY-N0829. | |
| SHIP2-IN-1 | SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 μM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimers disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2252247-80-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112700. | |
| SHLP2 | SHLP2 (Small humanin-like peptide 2) is a small molecule peptide encoded by mitochondrial DNA, belonging to mitochondria derived peptide. SHLP2 has the activity of regulating apoptosis and inhibits cell death. SHLP2 binds to mitochondrial complex 1. SHLP2 improves mitochondrial metabolism by increasing respiration and biogenesis, reducing ROS, and decreasing mtDNA oxidation. SHLP2 also regulated energy homeostasis through the activation of hypothalamic neurons. SHLP2 can be used in the study of diseases related to mitochondrial dysfunction and anti-aging diseases, such as age-related macular degeneration and Parkinsons disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Small humanin-like peptide 2. CAS No. 1191923-93-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10409. | |
| SHMT-IN-1 | SHMT-IN-1 is a Plasmodium falciparum Serine Hydroxymethyltransferase (PfSHMT) inhibitor with an IC50 of 350 nM. SHMT-IN-1 can be used for the research of malaria[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1508286-18-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129651. | |
| SHMT-IN-2 | SHMT-IN-2 is a stereo specific inhibitor of human SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 can block the growth of many human cancer cells, and has sensitivity for B-cell lymphomas[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2102681-49-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129226. | |
| Shogaol | Shogaol ([6]-Shogaol), an active compound isolated from Ginger (Zingiber officinale Rosc), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation. Uses: Scientific research. Category: Signaling pathways. Alternative Names: [6]-Shogaol; 6-Shogaol. CAS No. 555-66-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14616. | |
| SHP099 | SHP099 is an allosteric SHP2 inhibitor, with IC50s of 0.690, 1.241, 0.416, 1.968, 2.896 μM for SHP2, SHP2D61Y, SHP2E69K, SHP2A72V, SHP2E76K. SHP099 inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC50: 0.32 and 1.73 μM). SHP099 inhibits RAS-ERK signaling and inhibits tumor growth[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1801747-42-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100388. | |
| SHP099 monohydrochloride | SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC50 of 70 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2200214-93-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-100388A. | |
| SHP1 activator 1 | SHP1 activator 1 (Compound 3n) is an activator for src homology-2 domain-containing protein tyrosine phosphatase 1(SHP1) with an EC50 of 17.66 μM. SHP1 activator 1 inhibits the proliferation of ABC-DLBCL cells, induces apoptosis by inhibiting STAT3 signaling pathway. SHP1 activator 1 emitts blue and green fluorescence signalis in MDA-MB-231 cell, and can be used as a cell imaging agent[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3113070-25-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-168929. | |
| SHP2-D26 | SHP2-D26 is a first, potent and effective SHP2 PROTAC degrader. SHP2-D26 induces SHP2 degradation requires binding to VHL-1 and SHP2 proteins. SHP2-D26 is also neddylation- and proteasome-dependent. SHP2-D26 can be used for the study of esophageal cancer and acute myeloid leukemia (Pink: SHP2 ligand (HY-176797); Blue: VHL ligand (HY-150803); Black: linker)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2458219-65-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-145162. | |
| SHP2-IN-9 | SHP2-IN-9 is a specific SHP2 inhibitor (IC50 =1.174 μM) with enhanced blood-brain barrier penetration. SHP2-IN-9 shows 85-fold more selective for SHP2 than SHP1. SHP2-IN-9 inhibits SHP2-mediated cell signal transduction and cancer cell proliferation, and inhibits the growth of cervix cancer tumors and glioblastoma growth in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2987135-92-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115925. | |
| SHP836 | SHP836 is a SHP2 allosteric inhibitor, with an IC50 of 12 μM for the full length SHP2[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1957276-35-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-121879. | |
| SHR-1701 | SHR-1701 (Retlirafusp alfa) is a bifunctional fusion protein targeting PD-L1 and TGF-β for cancer research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Retlirafusp alfa. CAS No. 2891860-17-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99944. | |
| SHR5428 | SHR5428 is a potent, orally active, selective and noncovalent inhibitor of CDK7 with highly potent CDK7 enzymatic activity (IC50=2.3 nM). SHR5428 inhibits triple negative breast cancer cellular activity on MDA-MB-468 cell (IC50=6.6 nM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3054791-71-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-155787. | |
| SHU 9119 | SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC50 values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 168482-23-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0227. | |
| SI-109 | SI-109 is a potent STAT3 SH2 domain inhibitor (Ki=9 nM) with antitumor activity. SI-109 effectively inhibits the transcriptional activity of STAT3 (IC50=3 μM). SI-109 and an analog of CRBN ligand lenalidomide have been used to design PROTAC STAT3 degrader SD-36[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2429877-30-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129603. | |
| SI-113 | SI-113 is a SGK1 inhibitor, with an IC50 of 600 nM. SI113 induces autophagy[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1392816-46-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-117357. | |
| SIAIS178 | SIAIS178 is a potent and selective BCR-ABL degrader based on PROTAC technology with an IC50 of 24 nM. SIAIS178 causes effective degradation of BCR-ABL protein by recruiting Von Hippel-Lindau (VHL) E3 ubiquitin ligase. SIAIS178 has anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2376047-73-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128756. | |
| Sialylglycopeptide | Sialylglycopeptide is an orally active glycopeptide found in egg yolk. Sialylglycopeptide inhibits the binding of Salmonella enteritidis and Escherichia coli to intestinal cells, and protects mice from Salmonella infection. Sialylglycopeptide can be used in the research of Salmonella infection[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 189035-43-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3302. | |
| Sialyl-Lewis X | Sialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. Sialyl-Lewis X binds to ELAM-1 and CD62 and has the ability?to inhibits CD62-mediated neutrophil recruitment to sites of inflammation[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: sLeX. CAS No. 98603-84-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-W020790. | |
| Sibeprenlimab | Sibeprenlimab (VIS649) is a humanized IgG2 monoclonal antibody which inhibits a proliferation-inducing ligand (APRIL). Sibeprenlimab suppresses pathogenic immunoglobulins (IgA and IgM), while preserving antibody responses to mRNA-based vaccines against SARS-COV-2. Sibeprenlimab reduces urinary protein-to-creatinine ratio (UPCR) and glomerular filtration rate (GFR). Sibeprenlimab is promising for the research of IgA nephropathy (IgAN)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VIS649. CAS No. 2382896-07-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P99901. | |
| Sibiricose A5 | Sibiricose A5 is an oligosaccharide ester isolated from Polygalae Radix with potent antioxidant activity[1][2]. Uses: Scientific research. Category: Natural products. CAS No. 107912-97-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2167. | |
| Sibofimloc | Sibofimloc (Antibiotic-202) is a first-in-class, gut-restricted, orally active FimH adhesion inhibitor extracted from patent WO2014100158A1, Compound Example 202. Sibofimloc has anti-bacterial infective activity. Sibofimloc is developed for inflammatory bowel disease (IBD)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Antibiotic-202. CAS No. 1616113-45-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12820. | |
| Sibrotuzumab | Sibrotuzumab (BIBH 1) is a humanized IgG1 monoclonal antibody targets fibroblast activation protein (FAP). Sibrotuzumab can be used for the research of colorectal cancer and non-small cell lung cancer (NSCLC)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BIBH 1; Anti-Human FAP Recombinant Antibody. CAS No. 216669-97-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P99269. | |
| SID 26681509 | SID 26681509 is a potent, reversible, competitive, and selective inhibitor of human cathepsin L with an IC50 of 56 nM. SID 26681509 inhibits in vitro propagation of malaria parasite Plasmodium falciparum and inhibits Leishmania major with IC50s of 15.4 μM and 12.5 μM, respectively. SID 26681509 shows no inhibitory activity against cathepsin G[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 958772-66-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-103353. | |
| SID 7969543 | SID 7969543 is a selective SF-1 (steroidogenic factor 1, NR5A1) inhibitor with an IC50 of 760 nM. SID 7969543 inhibits SF-1-triggered luciferase expression with IC50 of 30 nM. SF-1 is a transcription factor belonging to the nuclear receptor superfamily[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 868224-64-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107404. | |
| SID-852843 | SID-852843 is a WNV NS2B-NS3 proteinase inhibitor. SID-852843 can inhibit WNV NS2B-NS3 proteinase activity with IC50 value of 0.105 μM. SID-852843 can be used for the research of virus infection[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 909859-19-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134910. | |
| Sifalimumab | Sifalimumab (MEDI-545) is an anti-IFNα monoclonal antibody. Sifalimumab suppresses the abnormal immune activity by binding to multiple interferon-alpha (IFNα) subtypes. Sifalimumab can be used in systemic lupus erythematosus (SLE) research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MEDI-545; MDX 1103. CAS No. 1006877-41-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99219. | |
| σ1 Receptor antagonist-1 | σ1 Receptor antagonist-1 is a highly potent and selective sigma 1 receptor antagonist (pKi=10.28). σ1 Receptor antagonist-1 inhibits cell growth, arrests cell cycle at G0/G1 phase and induces apoptosis of MCF-7/ADR cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1204401-49-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10815. | |
| Sigvotatug | Sigvotatug (SGN-B6A antibody) is a human IgG1 κ monoclonal antibody against ITGB6. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001). Sigvotatug can be used as an ADC antibody to synthesize ADC Sigvotatug vedotin (HY-164957)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SGN-B6A antibody. CAS No. 2764774-90-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990764. | |
| Sigvotatug vedotin | SGN-B6A is an ADC, which targets integrin beta-6 (ITGB6) through human IgG1 monoclonal antibody Sigvotatug (HY-P990764), and exhibits cytotoxicity against multiple integrin beta-6-positive cancer cell through mitotic inhibitor MMAE (HY-15162)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SGN-B6A; PF-08046047. CAS No. 2764774-91-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-164957. | |
| Sildenafil | Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UK-92480. CAS No. 139755-83-2. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-15025. | |
| Sildenafil citrate | Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UK-92480 citrate. CAS No. 171599-83-0. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-15025A. | |
| Sildenafil-d3 | Sildenafil-d3 is deuterium labeled Sildenafil-d3. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: UK-92480-d3. CAS No. 1126745-90-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-15025S. | |
| Silevertinib | Silevertinib (BDTX-1535) is an irreversible, brain-penetrant, selective and orally active EGFR inhibitor with wild-type EGFR-sparing. Silevertinib targets key EGFR resistance mutations, including the kinase domain (C797S, L718Q, G724S, S768I), extracellular domain (EGFRvIII, A289X), and EGFR amplification. Silevertinib exerts anti-tumor activity with well tolerated in vivo. Silevertinib can be used for non-small cell lung cancer (NSCLC) and glioblastoma (GBM) research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BDTX-1535; EGFR-IN-76. CAS No. 2607829-38-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153268. | |
| Silica sand, 1-2mm | Silica sand, 1-2 mm is an inorganic, inert, and biocompatible (under certain conditions) solid matrix composed of high-purity silica particles. Silica sand, 1-2 mm is primarily used as a physical functional material in biochemical research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 14808-60-7. Pack Sizes: 500 g; 1 k g; 2.5 k g. Product ID: HY-W096178B. | |
| Silmitasertib | Silmitasertib (CX-4945) is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CX-4945. CAS No. 1009820-21-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-50855. | |
| Silmitasertib sodium salt | Silmitasertib sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CX-4945 sodium salt. CAS No. 1309357-15-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-50855B. | |
| Silodosin | Silodosin (KAD 3213; KMD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with Ki values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH[1][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KAD 3213; KMD 3213. CAS No. 160970-54-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10122. | |
| Siltuximab | Siltuximab is an anti-IL-6 (interleukin-6) monoclonal antibody, and shows antitumor activity. Siltuximab can be used in Multicentric Castleman's Disease (MCD) and COVID-19 research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CNTO-328. CAS No. 541502-14-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9956. | |
| Silver trifluoromethanesulfonate | Silver trifluoromethanesulfonate, a perfluoroalkanesulfonic acid, is one of the superior catalysts for C- or O-acylation. Silver trifluoromethanesulfonate is widely used as a cationic catalyst in promoting Friedel-Crafts reactions and esterification reactions[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Triflic acid silver; Perfluoromethanesulfonic acid silver; Fluorad FC 24 silver. CAS No. 2923-28-6. Pack Sizes: 10 g; 25 g; 100 g. Product ID: HY-W020983. | |
| Silvestrol | Silvestrol is a eukaryotic translation initiation factor 4A (eIF4A) inhibitor isolated from Agave americana Linn. Silvestrol induces autophagy and caspase-mediated apoptosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Silvestrol. CAS No. 697235-38-4. Pack Sizes: 1 mg; 2 mg; 5 mg; 10 mg. Product ID: HY-13251. | |
| Silvestrol aglycone | Silvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively. Anti-cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 960365-65-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13250. | |
| Silybin | Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Silibinin. CAS No. 802918-57-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-N0779A. | |
| Silybin A | Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Silibinin A. CAS No. 22888-70-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13748. | |
| Silybin B | Silybin B (Silibinin B) is an orally active amyloid-β aggregation inhibitor and ATR pathway activator that can cross the blood-brain barrier. Silybin B inhibits Aβ fibril formation and promotes amorphous aggregate formation, while activating the ATR-mediated DNA damage repair pathway and inhibiting JNK/p38 MAPK signaling. Silybin B can reduce Cisplatin (HY-17394)-induced neuronal DNA damage and apoptosis. Silybin B has anti-oxidative stress, cell cycle regulation and neuroprotective activities. Silybin B is mainly used in the study of Alzheimer's disease and Cisplatin chemotherapy-related neurotoxicity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Silibinin B. CAS No. 142797-34-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-N7046. | |
| Silychristin | Silychristin is an abundant flavonolignan present in the fruits of Silybum marianum, with antioxidant properties. Silychristin is a potent inhibitor of the thyroid hormone transporter MCT8, and elicits a strong inhibition of T3 uptake with an IC50 of 110 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 33889-69-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0647. | |
| Silymarin | Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin is an effective SARS-CoV-2 main protease (Mpro) inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research[1][2][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 65666-07-1. Pack Sizes: 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-N7073. | |
| SIM1 | SIM1 is a potent von Hippel-Lindau (VHL)-based trivalent PROTAC capable of degradation for all BET family members, with preference for BRD2 degradation (IC50=1.1 nM; Kd=186 nM). SIM1 shows sustained anti-cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2719051-84-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-141438. | |
| Simepdekinra | Simepdekinra (LY4100511; DC-853) is an IL-17A antagonist. Simepdekinra can be used in the research of moderate to severe plaque-type psoriasis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY4100511; DC-853. CAS No. 2978700-29-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-177129. | |
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