MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Risedronic acid | Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC50 of 20.3 μM)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Risedronate. CAS No. 105462-24-6. Pack Sizes: 100 mg; 500 mg. Product ID: HY-B0148. |  |
| Risedronic acid-d4 | Risedronic acid-d4 (Risedronate-d4) is the deuterium labeled Risedronic acid (HY-B0148). Risedronic acid (Risedronate) is a bisphosphonate and potent antiresorptive agent. Risedronic acid induces Apoptosis. Risedronic acid inhibits the transfer of farnesyl pyrophosphate groups to parasite proteins. Risedronic acid inhibits osteoclast-mediated bone resorption and alters bone metabolism. Risedronic acid inhibits blood-stage Plasmodium falciparum (IC50 of 20.3 μM)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Risedronate-d4. CAS No. 1035438-80-2. Pack Sizes: 1 mg. Product ID: HY-B0148S. | |
| Rislenemdaz | Rislenemdaz (CERC-301) is an orally bioavailable and selective N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B) antagonist with Ki and IC 50 of 8.1 nM and 3.6 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-0657; CERC-301. CAS No. 808732-98-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-106441A. | |
| Risperidone | Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R 64 766. CAS No. 106266-06-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11018. | |
| Risperidone-d4 | Risperidone-d4 is the deuterium labeled Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R 64 766-d4. CAS No. 1020719-76-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-110232. | |
| Ristocetin A sulfate | Ristocetin A sulfate (Ristomycin III) is a glycopeptide antibiotic that binds to von Willebrand factor (VWF) and bacterial cell wall components. Ristocetin A sulfate interferes with the biosynthesis of bacterial peptidoglycan by inhibiting transpeptidation. As an inducer of platelet adhesion and aggregation, Ristocetin A sulfate drives conformational changes by binding to the A1 domain of VWF, thereby activating downstream signaling pathways and promoting cytoskeletal rearrangement. Ristocetin A sulfate not only enhances platelet adhesion and spreading on immobilized VWF, but also induces the formation of asymmetric dimers with anticooperativity between platelets and plasma VWF. Ristocetin A sulfate is widely used in studies related to thromboembolic diseases and bacterial infections[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ristomycin III. CAS No. 90831-71-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-138053. | |
| Risvodetinib | Risvodetinib (IkT-148009) is an orally active, selective and brain-penetrant protein tyrosine kinase inhibitor, displaying excellent target efficacy against c-Abl1, c-Abl2/Arg with IC50 values of 33 nM, 14 nM, respectively. Risvodetinib suppresses c-Abl activation and substantially protects dopaminergic neurons from degeneration in mouse models of both inherited and sporadic Parkinsons disease (PD), which is promising for research in the field of PD[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IkT-148009. CAS No. 2031185-00-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148794. | |
| Risvutatug | HS-20093 Antibody (GSK5764227 Antibody) is an antibody targeting B7-H3, which can be used to synthesize the ADC HS-20093. HS-20093 Antibody exhibits anti-tumor activity. HS-20093 Antibody can be studied in research for small cell lung cancer, relapsed or refractory osteosarcoma, and advanced solid tumors[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HS-20093 Antibody; GSK5764227 Antibody. CAS No. 3042848-87-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P991537. | |
| Risvutatug rezetecan | Risvutatug rezetecan (HS-20093; GSK5764227) is a B7-H3-targeting antibody-drug conjugate (ADC). Risvutatug rezetecan binds to B7-H3 on tumor cells and delivers a topoisomerase I inhibitor payload via a tumor microenvironment-responsive cleavable linker. Risvutatug rezetecan is applicable for the research of extensive-stage small cell lung cancer and non-small cell lung cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HS-20093; GSK5764227. CAS No. 3042849-33-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-185279. | |
| Ritanserin | Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R 55667. CAS No. 87051-43-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10791. | |
| Ritlecitinib | Ritlecitinib (PF-06651600) is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 μ M). Ritlecitinib rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-06651600. CAS No. 1792180-81-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-100754. | |
| Ritonavir | Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM. Ritonavir (ABT 538) can penetrate the blood brain barrier (BBB)[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT 538; RTV. CAS No. 155213-67-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-90001. | |
| Rituximab | Rituximab is an anti-CD20 chimeric monoclonal antibody used for research of certain autoimmune diseases and cancer. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-Human CD20 type I, Chimeric Antibody; HSDB 7455; IDEC-C2B8. CAS No. 174722-31-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P9913. | |
| Rituximab (anti-CD20) | Rituximab (anti-CD20) is an anti-CD20 chimeric monoclonal antibody used to treat certain autoimmune diseases and types of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 174722-31-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P9913A. | |
| Rivaroxaban | Rivaroxaban (BAY 59-7939) is a highly potent, selective and direct Factor Xa (FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC50 0.7 nM; Ki 0.4 nM)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 59-7939. CAS No. 366789-02-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50903. | |
| Rivastigmine | Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ENA 713 free base; SDZ-ENA 713 free base. CAS No. 123441-03-2. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-17368. | |
| Riviciclib hydrochloride | Riviciclib hydrochloride (P276-00) is a potent cyclin-dependent kinase (CDK) inhibitor, which inhibits CDK9-cyclinT1, CDK4-cyclin D1, and CDK1-cyclinB with IC50s of 20 nM, 63 nM, and 79 nM, respectively[1][2].Riviciclib hydrochloride (P276-00) shows antitumor activity on cisplatin-resistant cells[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: P276-00. CAS No. 920113-03-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16559. | |
| Rizatriptan benzoate | Rizatriptan benzoate is the agonist for 5-HT1B and 5-HT1D. Rizatriptan benzoate has a peripheral vasoconstrictive effect, penetrates the intact blood-brain barrier, and inhibits pain neurotransmission in the central nervous system[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK 462. CAS No. 145202-66-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0206. | |
| Rizavasertib | A-443654 is a pan-Akt inhibitor and has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: A-443654. CAS No. 552325-16-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10425. | |
| RJG-2051 | RJG-2051 is a selective covalent aldo-keto reductase family 1 member C3 (AKR1C3) inhibitor with an IC50 value of 13 nM. RJG-2051 interferes with the metabolic process of substrates such as androgens, estrogens, and prostaglandins by AKR1C3. RJG-2051 is promising for research of cancers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2851993-77-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-176084. | |
| RJPXD33 | RJPXD33 is the inhibitor for LpxD and LpxA with IC50 of 3.5 μM and 19 μM. RJPXD33 RJPXD33 inhibits LpxD and LpxA in E. coli with Kd of 6 μM and 20 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1613160-77-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P10848. | |
| (R)-(-)-JQ1 Enantiomer | (R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 potently decreases expression of both BRD4 target genes, whereas (R)-(-)-JQ1 Enantiomer has no effect. Uses: Scientific research. Category: Signaling pathways. CAS No. 1268524-71-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13030A. | |
| RJW100 | RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC50s of 6.6 and 7.5, respectively[1]. RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1276664-20-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-131445. | |
| RK-287107 | RK-287107 is a potent and specific tankyrase inhibitor with IC50s of 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively. RK-287107 blocks colorectal cancer cell growth[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2171386-10-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123892. | |
| RK-33 | RK-33 is an RNA helicase inhibitor against DDX3, and inhibits its helicase activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 1070773-09-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100455. | |
| RK-582 | RK-582 is a tankyrase inhibitor, antitumor agent, and orally bioavailable growth inhibitor, with an IC50 of 36.1 nM against human tankyrase-1 and an IC50 of 39.2 nM against human tankyrase-2. In APC-mutated colorectal cancer cells, the sensitivity to RK-582 correlates with the level of active β-catenin, while drug resistance associates with PIK3CA mutation. RK-582 can be used for the research of colorectal cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2171388-28-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137849. | |
| RK-701 | RK-701 is an highly selective and non-genotoxic inhibitor of G9a with IC50 value of 23-27 nM. RK-701 selectively up-regulates HbF, γ- Globin, BGLT3 expression, down-regulates H3K9me2 expression. RK-701 also has inhibition for BCL11A and ZBTB7A[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2648855-18-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152775. | |
| (R)-Ketorolac | (R)-Ketorolac is an orally active Cdc42 and Rac1 inhibitor. (R)-Ketorolac inhibits GTPase. (R)-Ketorolac alters ovarian cancer cell behaviors critical for invasion and metastasis. (R)-Ketorolac ameliorates cancer-associated cachexia[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Ketorolac. CAS No. 66635-93-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0580B. | |
| (R)-KRAS G12D inhibitor 28 hydrochloride dihydrate | (R)-KRAS G12D inhibitor 28 hydrochloride dehydrate is the hydrochloride dehydrate of (R)-KRAS G12D inhibitor 28 (HY-172626). KRAS G12D inhibitor 28 (Compound 2) is a KRAS G12D inhibitor. KRAS G12D inhibitor 28 (Compound 2) can be used in the cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3081520-70-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-172626A. | |
| RL5a | RL5a (compund C23) is a SETD8 inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 133671-66-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-138886. | |
| RL648_81 | RL648_81 is a specific KQT-like subfamily 2/3 (KCNQ2/3) activator with an EC50 of 190 nM. RL648_81 robustly shifts the V1/2 of KCNQ2/3 channels towards hyperpolarized potentials.RL648_81 does not shift the V1/2 of either KCNQ4 or KCNQ5.RL648_81 has?the?potential?for?neurologic disorders associated with neuronal hyperexcitability research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1919050-87-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-123264. | |
| (R)-Leucic acid | (R)-Leucic acid (D-α-Hydroxyisocaproic acid) is an orally active D-isomer of the α-hydroxy analogue of Leucine (HY-N0486). (R)-Leucic acid is a metabolite of Lactobacillus and can promote intestinal fatty acid absorption by upregulating CD36 expression. (R)-Leucic acid can be used to study microbe-host interactions and the regulation of lipid metabolism by probiotics[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-α-Hydroxyisocaproic acid. CAS No. 20312-37-2. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-30216. | |
| (R)-Lith-O-Asp | (R)-Lith-O-Asp (α-2,3-Sialyltransferase-IN-1) is a noncompetitive α-2,3-sialyltransferase inhibitor with an IC50 of 6 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: α-2,3-Sialyltransferase-IN-1. CAS No. 881179-06-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112535. | |
| RLX-33 | RLX-33 is a potent, selective and blood-brain barrier (BBB) penetrant relaxin family peptide 3 (RXFP3) antagonist, also blocks relaxin-3-induced ERK1/2 phosphorylation, with IC50 values of 2.36 μM for RXFP3, 7.82 and 13.86 μM for ERK1 and ERK2 phosphorylation, respectively. RLX-33 can block the stimulation of food intake induced by the RXFP3-selective agonist R3/I5 in rats. RLX-33 can be used for the research of metabolic syndrome[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2784577-71-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150700. | |
| RM-018 | RM-018 is a potent, functionally distinct tricomplex KRASG12C active-state inhibitor. RM-018 retains the ability to bind and inhibit KRASG12C/Y96D and could overcome resistance. RM-018 binds specifically to the GTP-bound, active [RAS(ON)] state of KRASG12C[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2641993-55-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141477. | |
| (R)-M8891 | (R)-M8891 (compound R-9) is a less active isomer of M8891. M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2575547-29-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-133016A. | |
| (R)-Mandelonitrile lyase | (R)-Mandelonitrile lyase (Mandelonitrile Lyase) is an enzyme that can be isolated from Prunus species[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Mandelonitrile Lyase. CAS No. 9024-43-5. Pack Sizes: 100 U. Product ID: HY-P2836. | |
| RMC-4550 | RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 2172651-73-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116009. | |
| RMC-4627 | RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth. Uses: Scientific research. Category: Signaling pathways. CAS No. 2250059-52-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-143510. | |
| RMC-4998 | RMC-4998 is an orally active inhibitor targeting the active or GTP-bound state of the KRASG12C mutant. RMC-4998 can form a ternary complex with intracellular CYPA and the activated KRASG12C mutant, with an IC50 value of 28 nM. RMC-4998 can inhibit ERK signaling in KRASG12C mutant cancer cells and induce apoptosis. RMC-4998 can be used for tumor research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2642037-07-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156671. | |
| RMC-5127 | RMC-5127 is a small molecule inhibitor that binds to GTP-targeted KRASG12V, with oral bioavailability and blood-brain barrier permeability. RMC-5127 inhibits the activities of the RAS and MAPK pathways, suppresses the proliferation of KRASG12V-mutant cancer cells and induces their apoptosis. RMC-5127 can be used for the research of KRASG12V-mutant non-small cell lung cancer, pancreatic ductal adenocarcinoma, colorectal cancer and intracranial KRASG12V tumors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3082166-76-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-173629. | |
| RMC-5552 | RMC-5552 is a potent and selective mTORC1 inhibitor. RMC-5552 inhibits phosphorylation of mTORC1 pS6K and p4EBP1 with IC50s of 0.14 nM and 0.48 nM, respectively. RMC-5552 shows much lower pAKT inhibition (IC50 of 19 nM), resulting in mTORC1/mTORC2 selectivity approaching 40-fold. RMC-5552 has anti-cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2382768-62-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-132168. | |
| RMC-6272 | RMC-6272 (RM-006) is a bi-steric mTORC1-selective inhibitor. RMC-6272 exhibits potent and selective (> 10-fold) inhibition of mTORC1 over mTORC2. RMC-6272 shows improved inhibition of mTORC1 in comparison to Rapamycin, and induces more cell death in TSC2 null tumors[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RM-006. CAS No. 2382769-46-0. Pack Sizes: 1 mg; 10 mg. Product ID: HY-134904. | |
| RMC-7977 | RMC-7977 is an orally active triple-complex RAS inhibitor that can simultaneously bind to cyclophilin A (CYPA) (Kd = 195 nM) and KRAS (G12V) (Kd = 292 μM). It exhibits broad-spectrum inhibitory activity against KRAS, NRAS, and HRAS proteins and their various wild-type and mutant variants. RMC-7977 induces apoptosis by inhibiting the phosphorylation of ERK, CRAF, and RSK, as well as increasing PARP cleavage. This leads to tumor regression, reduces resistance in KRASG12C cancer models, and demonstrates good tolerability across various RAS cancer models[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2765082-12-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-156498. | |
| (R)-mchm5U | (R)-mchm5U is a diastereomer of (S)-mchm5U (HY-153100A)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 89665-84-9. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153100. | |
| (R)-Methanandamide | (R)-Methanandamide (AM-356), an analog of the endocannabinoid ligand Anandamide, is a potent CB1 agonist with a Ki of 20 nM. (R)-Methanandamide also activates vanilloid (TRPV1) receptors[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AM-356. CAS No. 157182-49-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101389. | |
| R(+)-Methylindazone | R(+)-Methylindazone (R(+)-IAA-94) is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-Methylindazone inhibits Nef-sdAb19 (single-domain antibody) interaction and binds to negative factor (Nef)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R(+)-IAA-94. CAS No. 54197-31-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12693. | |
| (R)-MG-132 | (R)-MG-132 ((S,R,S)-(-)-MG-132) is the enantiomer of MG-132. (R)-MG-132 is a proteasome inhibitor with weaker cell cytotoxicity than MG-132[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S,R,S)-(-)-MG-132; Z-Leu-D-Leu-Leu-al. CAS No. 1211877-36-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13259C. | |
| RN-1747 | RN-1747 is a selective TRPV4 channel agonist, with EC50 values of 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4, respectively. RN-1747 acts as an antagonist of TRPM8, with an IC50 of 4 μM. Topical cutaneous administration of RN-1747 induces hypothermia, increases tail heat loss via cutaneous vasodilation, and promotes cold-seeking behavior in rats. Intracerebroventricular administration of RN-1747 does not induce hypothermia in rats[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1024448-59-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19976. | |
| RN-1 dihydrochloride | RN-1 dihydrochloride is a potent, brain-penetrant, irreversible and selective lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 70 nM. RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC50 values of 0.51 μM and 2.785 μM respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1781835-13-9. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-110130. | |
| RNAIII-inhibiting peptideTFA | RNAIII-inhibiting peptide(TFA) is a potent inhibitor of Staphylococcus aureus, effective in the diseases such as cellulitis, keratitis, septic arthritis, osteomylitis and mastitis. Uses: Scientific research. Category: Signaling pathways. CAS No. 2703745-76-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1452A. | |
| RNase A, Bovine pancreas | RNase A (Bovine pancreatic RNase) is a widely used Endonuclease in DNA purification by specifically hydrolyzing cytosine or uracil residues of RNA. RNase A degrades the RNA in the RNA/DNA duplex. RNase A catalyses the breakdown of 3',5'-phosphodiester linkages of single stranded RNA. RNase A family members in organisms are tightly involved in various physiological and pathological processes including cell growth and development, proliferation, differentiation and migration. Dysregulation of RNase A activity or expression level is closely related to pancreatic, ovarian, bladder and thyroid cancer. RNase A has tumor cell-killing ability[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ribonuclease A; EC 4.6.1.18; RNase A. CAS No. 9001-99-4. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-129046. | |
| RNase A, Recombinant (animal free) | RNase A (Bovine pancreatic RNase) is a widely used Endonuclease in DNA purification by specifically hydrolyzing cytosine or uracil residues of RNA. RNase A degrades the RNA in the RNA/DNA duplex. RNase A catalyses the breakdown of 3',5'-phosphodiester linkages of single stranded RNA. RNase A family members in organisms are tightly involved in various physiological and pathological processes including cell growth and development, proliferation, differentiation and migration. Dysregulation of RNase A activity or expression level is closely related to pancreatic, ovarian, bladder and thyroid cancer. RNase A has tumor cell-killing ability. RNase A, Recombinant (animal free) is recombinant RNase A with no animal-derived components[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9001-99-4. Pack Sizes: 10 mg; 50 mg; 100 mg. Product ID: HY-129046I. | |
| RNase L-IN-2 | RNase L-IN-2 (compound 2) is an activtor of RNase L with EC50 value of 22 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 357618-26-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-121834. | |
| RNA splicing modulator 1 | RNA splicing modulator 1 (compound 233) is a RNA splicing modulator, with an AC50 value of <100 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2726461-38-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-150246. | |
| RNA splicing modulator 3 | RNA splicing modulator 3 is an RNA splicing modulator. RNA splicing modulator 3 modulates nucleic acid splicing, including pre-mRNA splicing[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2726461-43-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-150248. | |
| RNF114 ligand 1 | RNF114 ligand 1 is an E3 Ubiquitin ligase RNF114 ligand[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 900137-36-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-156499. | |
| (R)-Nimodipine | (R)-Nimodipine ((R)-BAY-e 9736) is an orally active, blood-brain barrier-permeable L-type calcium channel blocker with an IC50 of 5 nM. (R)-Nimodipine inhibits corticosterone release by blocking calcium channels on the hypothalamic-pituitary-adrenal axis, thereby reversing immobilization stress-induced memory impairment and behavioral abnormalities. (R)-Nimodipine is widely used in studies related to aneurysmal subarachnoid hemorrhage, cerebral ischemia, epilepsy, age-related degenerative neurological diseases, and alcohol intoxication[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-BAY-e 9736. CAS No. 77940-92-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0265A. | |
| RNPA1000 | RNPA1000, an antibiotic, is a potent RnpA inhibitor and inhibits RnpA-mediated cellular RNA degradation. RNPA1000 inhibits tRNA maturation with an IC50 of 175 μM. RNPA1000 displays broad-spectrum antimicrobial activities and inhibits staphylococcal and all Gram-positive bacterial pathogens activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 359600-10-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-12824. | |
| RNS peptide | RNS peptide is a randomly scrambled control peptide that can be used as a negative control for MANS peptide (HY-P10218)[1]. Uses: Scientific research. Category: Peptides. CAS No. 901117-08-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10776. | |
| Ro 08-2750 | Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor which binds to NGF, and with an IC50 of ~ 1 μM. Ro 08-2750 inhibits NGF binding to p75NTR selectively over TRKA[1]. Ro 08-2750 is a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 37854-59-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108466. | |
| RO1138452 | RO1138452 is a potent and selective IP (prostacyclin) receptor antagonist. RO1138452 displays high affinity for IP receptors. In human platelets, pKi is 9.3±0.1; in a recombinant IP receptor system, pKi is 8.7±0.06. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CAY10441. CAS No. 221529-58-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108912. | |
| Ro15-4513 | Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR)[1]. Ro15-4513 is a potent ethanol antagonist[2]. Ro15-4513 has anti-anxiety effect[3]. Ro15-4513 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 91917-65-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103476. | |
| Ro 20-1724 | Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ro 20-174. CAS No. 29925-17-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100927. | |
| Ro24-7429 | Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 139339-45-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19149. | |
| RO27-3225 TFA | RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1373926-49-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2242A. | |
| RO-275 | RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6, 13.9 μM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2648837-04-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160505. | |
| RO2959 hydrochloride | RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC50 of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC50 of 25 nM. RO2959 hydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1219927-22-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-113618A. | |
| Ro 31-8220 mesylate | Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 mesylate can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ro 31-8220 methanesulfonate; Bisindolylmaleimide IX mesylate. CAS No. 138489-18-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13866. | |
| RO3244794 | RO3244794 is a potent and selective IP (prostacyclin) receptor antagonist, with a pKi of 7.7 and 6.9 in human platelet and recombinant IP receptor system, respectively. RO3244794 exhibits analgesic and anti-inflammatory potential[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 361457-01-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-164580. | |
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