MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Ribociclib hydrochloride | RRibociclib (LEE011) hydrochloride is an ATP-competitive and orally active CDK4/6 inhibitor that crosses the blood-brain barrier with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LEE011 hydrochloride. CAS No. 1211443-80-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15777A. |  |
| Ribociclib (Standard) | Ribociclib (Standard) is the analytical standard of Ribociclib. This product is intended for research and analytical applications. Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LEE011 (Standard). CAS No. 1211441-98-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15777R. | |
| Ribociclib succinate | RRibociclib (LEE011) succinate is an ATP-competitive and orally active CDK4/6 inhibitor that crosses the blood-brain barrier with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LEE011 succinate. CAS No. 1374639-75-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-15777B. | |
| Ribociclib succinate hydrate | RRibociclib (LEE011) succinate hydrate is an ATP-competitive and orally active CDK4/6 inhibitor that crosses the blood-brain barrier with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LEE011 succinate hydrate. CAS No. 1374639-79-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15777C. | |
| Ribocil | Ribocil is a selective inhibitor targeting the bacterial FMN riboswitch, regulating the bacterial riboflavin riboswitch. Ribocil competitively binds to the FMN binding site, mimicking the natural ligand FMN to induce conformational changes in the riboswitch, inhibiting ribB gene expression, reducing riboflavin synthesis, and thus inhibiting bacterial growth. Ribocil strongly inhibits GFP expression (EC50=0.3 μM). Ribocil exhibits in vivo antibacterial activity in a mouse model and can be used to study antibacterial drugs related to drug-resistant bacterial infections and bacterial riboflavin metabolic pathways[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1381289-58-2. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19487. | |
| Ribocil-C | Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches. Uses: Scientific research. Category: Signaling pathways. CAS No. 1825355-56-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19488A. | |
| Riboflavin | Riboflavin, an orally active and easily absorbed micronutrient, is a precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which serve as coenzymes for numerous enzymatic reactions and perform key metabolic functions by mediating the transfer of electrons in biological oxidation-reduction reaction[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Vitamin B2; E101. CAS No. 83-88-5. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g. Product ID: HY-B0456. | |
| Riboflavin phosphate sodium | Riboflavin phosphate sodium (FMN-Na) is a derivative of Riboflavin (vitamin B2) which is an essential nutrient for animals. Riboflavin phosphate sodium can be used for the research of progressive keratoconus, corneal ectasia and irregular astigmatism[1][2]. Riboflavine phosphate sodium is a very effective NAD+-recycling agent[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Riboflavine phosphate sodium; Riboflavin 5'-phosphate sodium; Riboflavine 5'-phosphate sodium. CAS No. 130-40-5. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg. Product ID: HY-B0964. | |
| Riboflavin (Standard) | Riboflavin (Standard) is the analytical standard of Riboflavin. This product is intended for research and analytical applications. Riboflavin, an orally active and easily absorbed micronutrient, is a precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which serve as coenzymes for numerous enzymatic reactions and perform key metabolic functions by mediating the transfer of electrons in biological oxidation-reduction reaction[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Vitamin B2 (Standard); E101 (Standard). CAS No. 83-88-5. Pack Sizes: 100 mg; 250 mg; 500 mg. Product ID: HY-B0456R. | |
| Riboflavin Tetrabutyrate | Riboflavin Tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 752-56-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B2239. | |
| Ribonucleic Acid, Transfer from Brewing yeast | Ribonucleic Acid, Transfer from Brewing yeast is tRNA, which is isolated from brewer yeast. Ribonucleic Acid, Transfer from Brewing yeast is arranged in a cloverleaf model in total sequence. Ribonucleic Acid, Transfer from Brewing yeast is utilized as a substrate in reactions with participant of tRNAs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9014-25-9. Pack Sizes: 50 mg; 100 mg. Product ID: HY-160971. | |
| Ribostamycin sulfate | Ribostamycin sulfate (Vistamycin sulfate) is a broad-spectrum aminoglycoside Antibiotic with bactericidal activity against Gram-positive cocci, Gram-negative cocci, bacilli, and drug-resistant strains. Ribostamycin sulfate also acts as an inhibitor of protein disulfide isomerase (PDI), with a binding constant KD of 319 μM for bovine PDI. Ribostamycin sulfate targets bacterial 16S ribosomal RNA and the 30S ribosomal subunit, causing translational misreading and thereby inhibiting bacterial protein synthesis. Ribostamycin sulfate disrupts the integrity of bacterial cell membranes, induces membrane pore formation, and leads to bacterial death. Ribostamycin sulfate can be used in studies related to bacterial infections[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Vistamycin sulfate. CAS No. 53797-35-6. Pack Sizes: 10 mM * 1 mL in Water; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1228. | |
| Ribupatide | Ribupatide is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. Enicepatide can be studied in antidiabetic research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2940971-65-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P11271. | |
| (R)-(-)-Ibuprofen | (R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-Ibuprofen. CAS No. 51146-57-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-78131B. | |
| Ricolinostat | Ricolinostat (ACY-1215) is a potent and selective HDAC6 inhibitor, with an IC50 of 5 nM. ACY-1215 also inhibits HDAC1, HDAC2, and HDAC3 with IC50s of 58, 48, and 51 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ACY-1215; Rocilinostat. CAS No. 1316214-52-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16026. | |
| Ricorfotide vedotin | Ricorfotide vedotin (CBP-1008) is a dual-ligand peptide-drug conjugate (PDC) conjugated to MMAE (HY-15162), targeting Folate receptor α (FRα) and TRPV6. Ricorfotide vedotin binds to FRα with high affinity and TRPV6 with low affinity. Ricorfotide vedotin has antitumor activity, and can be used in advanced solid tumor research (eg: colorectal cancer, breast cancer, non-small cell lung cancer, ovarian cancer, adrenocortical carcinoma and follicular dendritic cell sarcoma)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CBP-1008; LDC 10B. CAS No. 2082631-84-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P10762. | |
| Ridaforolimus | Ridaforolimus (MK-8669) is a potent and selective mTOR inhibitor; inhibits ribosomal protein S6 phosphorylation with an IC50 of 0.2 nM in HT-1080 cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-8669; Deforolimus; AP23573. CAS No. 572924-54-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50908. | |
| Ridinilazole | Ridinilazole is a novel antibacterial with MICs range of 0.06-0.25?μg/mL (MIC90=8?μg/mL) against C.?difficile. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SMT19969. CAS No. 308362-25-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16753. | |
| Ridogrel | Ridogrel (R 68070) is an orally active combined thromboxane A2 synthetase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker. Ridogrel is potent antiplatelet agent. Anti-inflammatory activities[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R 68070. CAS No. 110140-89-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0221. | |
| Rifabutin | Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ansamycin; LM-427. CAS No. 72559-06-9. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-17025. | |
| Rifabutin-d7 | Rifabutin-d7 is the deuterium labeled Rifabutin. Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ansamycin-d7; LM-427-d7. CAS No. 2747918-39-2. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-17025S. | |
| Rifalazil | Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase[1]. Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml[3]. Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB)[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KRM-1648; ABI-1648. CAS No. 129791-92-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105099. | |
| Rifampicin | Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities. Rifampicin shows anti-orthopoxvirus activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Rifampin; Rifamycin AMP. CAS No. 13292-46-1. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0272. | |
| Rifamycin S | Rifamycin S, a quinone, is an antibiotic against Gram-positive bacteria (including MRSA). Rifamycin S is the oxidized forms of a reversible oxidation-reduction system involving two electrons. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. Rifamycin S can be used for tuberculosis and leprosy[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 13553-79-2. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-125365. | |
| Rifamycin sodium | Rifamycin sodium (Rifamycin SV monosodium) is an orally active ansamycin antibiotic. Rifamycin sodium inhibits DNA-dependent RNA synthesis. Rifamycin sodium has antibacterial activity against Mycobacterium tuberculosis. Rifamycin sodium interferes with hepatic bile acid metabolism. Rifamycin sodium has anti-inflammatory effects. Rifamycin sodium can be used in the study of Mycobacterium tuberculosis, Bacteroides fragilis infection, and Lipopolysaccharide (HY-D1056B3)-induced inflammation[1][2][3][4][5][6][7][8][9][10][11]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Rifamycin SV sodium. CAS No. 14897-39-3. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg. Product ID: HY-B1907. | |
| Rifapentine | Rifapentine (DL 473) is an antibiotic used in tuberculosis research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DL 473; Cyclopentylrifampicin. CAS No. 61379-65-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-B0269. | |
| Rifasutenizol | Rifasutenizol (TNP-2198) is a dual-targeted antibacterial agent that has a good antibacterial effect on Helicobacter pylori infection. Rifasutenizol can be used in the study of microaerophilic and anaerobic bacterial infections[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TNP-2198. CAS No. 1001314-13-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144300. | |
| Rifaximin | Rifaximin, a gastrointestinal-selective antibiotic, binds the β-subunit of bacterial DNA-dependent RNA polymerase, resulting in inhibition of bacterial RNA synthesis. Rifaximin susceptibility is higher against Gram-positive strains (MIC: 0.03-5 mg/ml) compared to Gram-negative bacteria (MIC: 8-50 mg/mL)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 80621-81-4. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-13234. | |
| RIG012 | RIG012 is a potent RIG-I inhibitor with an IC50 of 0.71 μM using the NADH-coupled ATPase assay. RIG012 inhibits IFN-β and ISG hRsad2 expression[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2642218-43-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147124. | |
| Rigosertib | Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle[1][2]. Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ON-01910. CAS No. 592542-59-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12037A. | |
| Rigosertib sodium | Rigosertib sodium (ON-01910 sodium) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3K/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle[1][2]. Rigosertib sodium is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ON-01910 sodium. CAS No. 592542-60-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12037. | |
| Rilapladib | Rilapladib (SB 659032) is a selective Lp-PLA2 (lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 230 pM[1]. Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SB 659032. CAS No. 412950-08-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102004. | |
| Rilematovir | Rilematovir (JNJ-678) is a novel fusion protein inhibitor. Rilematovir has the potential for respiratory syncytial virus (RSV) research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ-678; JNJ-53718678. CAS No. 1383450-81-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112180. | |
| Riliprubart | Riliprubart (SAR 445088) is an anti-C1s humanized IgG4 monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system. Riliprubart selectively inhibits activated C1s and prevents the enzymatic action of C1 on its substrates C4 and C2, thus inhibiting the formation of the classical pathway C3 convertase, C4b2a. Riliprubart can be used to study complement-mediated diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SAR 445088. CAS No. 2756228-76-7. Pack Sizes: 1 mg; 2 mg; 5 mg; 10 mg. Product ID: HY-P990091. | |
| Rilmazafone hydrochloride | Rilmazafone hydrochloride (450191S) is a benzodiazepine (omega) ligand[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 450191S. CAS No. 85815-37-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00228. | |
| Rilmenidine hemifumarate | Rilmenidine hemifumarate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine hemifumarate is an alpha 2-adrenoceptor agonist. Rilmenidine hemifumarate induces autophagy. Rilmenidine hemifumarate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine hemifumarate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells [1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 207572-68-7. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100490A. | |
| Rilogrotug | Rilogrotug (AV-380) is a humanized IgG1 monoclonal antibody targeting GDF15[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AV-380. CAS No. 2894138-72-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P991190. | |
| Rilonacept | Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Arcalyst; IL 1 Trap; Interleukin 1 Trap. CAS No. 501081-76-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-108822. | |
| Rilotumumab | Rilotumumab (AMG 102) is an anti-HGF (anti-hepatocyte growth factor) monoclonal antibody, inhibits HGF/MET-driven signaling. Rilotumumab shows anti-tumor activity, and can be used in castration-resistant prostate cancer (CRPC) and solid tumor research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AMG 102. CAS No. 872514-65-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99217. | |
| Rilpivirine | Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R278474; TMC278; DB08864. CAS No. 500287-72-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10574. | |
| Riluzole | Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PK 26124. CAS No. 1744-22-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-B0211. | |
| Riluzole-13C,15N2 | Riluzole-13C,15N2 is the 13C and 15N labeled Riluzole[1]. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM[2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PK 26124-13C,15N2. CAS No. 1215552-03-6. Pack Sizes: 1 mg. Product ID: HY-B0211S. | |
| Riluzole hydrochloride | Riluzole hydrochloride is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PK 26124 hydrochloride. CAS No. 850608-87-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-B0211A. | |
| Rilvegostomig | Rilvegostomig (AZD-2936) is a bispecific humanized IgG1 antibody targeting PD-1 and TIGIT. Rilvegostomig induces tumor growth inhibition and modulates the tumor immune microenvironment. Rilvegostomig exhibits anti-tumor activity in metastatic non-small cell lung cancer (without prior immune checkpoint inhibitor treatment). Rilvegostomig can be used in research related to metastatic non-small cell lung cancer and endometrial cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD-2936. CAS No. 2640305-01-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990704. | |
| Rilzabrutinib | Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Brutons Tyrosine Kinase (BTK), with an IC50 of 1.3 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PRN1008. CAS No. 1575596-29-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112166. | |
| Rimantadine-d4 hydrochloride | Rimantadine-d4 (hydrochloride) is the deuterium labeled Rimantadine hydrochloride. Rimantadine is an orally active inhibitor for M2 protein, that blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 350818-67-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-B0338S. | |
| Rimcazole dihydrochloride | Rimcazole (BW 234U) dihydrochloride is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BW 234U dihydrochloride. CAS No. 75859-03-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108510. | |
| Rimegepant | Rimegepant (BMS-927711; BHV-3000) is an orally bioavailable and blood-brain barrier permeable antagonist of CGRP and AMY1 receptors, with a pIC50 of 8.01 and a Ki of 0.027 nM for human CGRP receptors. Rimegepant antagonizes cAMP production induced by αCGRP, βCGRP and amylin at CGRP and AMY1 receptors in humans, rats and mice, as well as at rat AMY3 receptors. Rimegepant can be used in research related to migraine [1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-927711; BHV-3000. CAS No. 1289023-67-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15498. | |
| Rimegepant sulfate hydrate | Rimegepant (BMS-927711) sulfate hydrate is a potent, orally active, selective and competitive calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki of 0.027 nM and an IC50 of 0.14 nM for hCGRP receptor. Rimegepant sulfate hydrate can be used for migraine research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-927711 sulfate hydrate; BHV-3000 sulfate hydrate. CAS No. 1374024-48-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15498A. | |
| Rimeporide | Rimeporide (EMD-87580) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1). Uses: Scientific research. Category: Signaling pathways. Alternative Names: EMD-87580. CAS No. 187870-78-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-19273. | |
| Rimiducid | Rimiducid (AP1903) is a dimerizer agent that acts by cross-linking the FKBP domains. Rimiducid (AP1903) dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AP1903. CAS No. 195514-63-7. Pack Sizes: 1 mg; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16046. | |
| Rimonabant | Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a Ki of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3). Uses: Scientific research. Category: Signaling pathways. Alternative Names: SR141716. CAS No. 168273-06-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14136. | |
| Rimonabant Hydrochloride | Rimonabant Hydrochloride (SR 141716A Hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant Hydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3). Uses: Scientific research. Category: Signaling pathways. Alternative Names: SR 141716A Hydrochloride. CAS No. 158681-13-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14137. | |
| R-IMPP | R-IMPP (PF-00932239) is an anti-secretagogue of PCSK9 (IC50=4.8 μM), which targets the 80S ribosome to inhibit PCSK9 protein translation[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-00932239. CAS No. 2133832-83-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101354. | |
| Rimteravimab | Rimteravimab (XVR011) is a bivalent VHH-Fc antibody with potent neutralizing activity with high stability, broad coverage and silenced Fc effector functions against the disease caused by SARS-CoV-2[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: XVR011. CAS No. 2540797-21-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99947. | |
| Rimtuzalcap | Rimtuzalcap (CAD-1883) is a first-in-class selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels). Rimtuzalcap can be used for the research of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CAD-1883. CAS No. 2167246-24-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109160. | |
| Rinatabart | HY-P990941 is an FOLR1-targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2853518-94-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P990941. | |
| Rineterkib | Rineterkib (compound B) is an orally available ERK1 and ERK2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer. Rineterkib hydrochloride can also inhibit RAF[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1715025-32-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114491. | |
| Rinucumab | Rinucumab (REGN 2176) is an anti-PDGFR-β antibody. Rinucumab is used for research on neovascular age-related macular degeneration[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REGN 2176. CAS No. 1569263-06-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99402. | |
| Rinzimetostat | Rinzimetostat (ORIC-944) is a selective, orally active, allosteric inhibitor targeting the EED subunit of polycomb repressive complex 2 (PRC2). Rinzimetostat is synergistic with androgen receptor pathway inhibitors (ARPIs) for the study of metastatic prostate cancer. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ORIC-944. CAS No. 2369769-29-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158102. | |
| Riociguat | Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 632521. CAS No. 625115-55-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-14779. | |
| RIP1/RIP3/MLKL activator 1 | RIP1/RIP3/MLKL activator 1 (Compound 6i) is a potent anti-glioma agent. RIP1/RIP3/MLKL activator 1 induces necroptosis through RIP1/RIP3/MLKL pathway. RIP1/RIP3/MLKL activator 1 exerts acceptable BBB permeability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2682850-41-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144828. | |
| Ripasudil | Ripasudil (K-115) is a specific inhibitor of ROCK, with IC50s of 19 and 51 nM for ROCK2 and ROCK1, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: K-115. CAS No. 887375-67-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15685. | |
| RIPK1-IN-4 | RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1481641-08-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18901. | |
| RIPK1-IN-7 | RIPK1-IN-7 is a potent and selective RIPK1 inhibitor with a Kd of 4 nM and an enzymatic IC50 of 11 nM. RIPK1-IN-7 exhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2300982-44-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119933. | |
| RIPK3-IN-1 | RIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC50 of 9.1 nM. RIPK3-IN-1 inhibits RIPK1 and RIPK2 with IC50s of 5.5 and >10 μM. RIPK3-IN-1 is also a c-Met kinase inhibitor with an IC50 of 1.1 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2361139-70-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131064. | |
| RIPK3-IN-3 | RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC50=10 nM). RIPK3 mediates the phosphorylation of Mixed Lineage Kinase (MLKL) and causes necroptosis, while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosis. RIPK3-IN-3 also downregulates CXCL5 secretion and inhibits AsPC-1 cell migration and invasion[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3052303-53-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149393. | |
| Ripretinib | Ripretinib (DCC-2618) is an orally bioavailable, selective KIT and PDGFRA switch-control inhibitor. Ripretinib (DCC-2618) targets and binds to both wild-type and mutant forms of KIT and PDGFRA specifically at their switch pocket binding sites, thereby preventing the switch from inactive to active conformations of these kinases and inactivating their wild-type and mutant forms. Ripretinib (DCC-2618) also inhibits multiple other kinase targets, such as FLT3 and KDR (or VEGFR-2)[1][2]. DCC-2618 exerts antineoplastic effect and induces apoptosis[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DCC-2618. CAS No. 1442472-39-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112306. | |
| Risankizumab | Risankizumab (BI 655066) is a humanised IgG monoclonal antibody, targeting IL-23 p19 subunit (Kd <10 pM) and inhibiting IL-17 production induced by human IL-23 in mouse splenocytes (IC50 = 2 pM). Risankizumab can be used to research immunological and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis and erythrodermic psoriasis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Risankizumab rzaa; BI 655066; ABBV-066. CAS No. 1612838-76-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99248. | |
| Risdiplam | Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RG7916; RO7034067. CAS No. 1825352-65-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109101. | |
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