MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Reversine | Reversine is a novel class of ATP-competitive Aurora kinase inhibitor with IC50s of 400, 500 and 400 nM for Aurora A, Aurora B and Aurora C, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 656820-32-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14711. |  |
| Revumenib | Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell based IC50 of 10-20 nM. Revumenib can be used for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SNDX-5613. CAS No. 2169919-21-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136175. | |
| Reynoutrin | Reynoutrin (Quercetin-3-D-xyloside) is a flavonoid from Psidium cattleianum, with antioxidant and radical-scavenging activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Quercetin-3-D-xyloside; Reinutrin. CAS No. 549-32-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N1354. | |
| Rezafungin acetate | Rezafungin acetate (Biafungin acetate) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin acetate shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp.[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Biafungin acetate; CD101 acetate; SP-3025 acetate. CAS No. 1631754-41-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108009A. | |
| Rezatapopt | Rezatapopt (PC14586) is an orally active antineoplastic agent. Rezatapopt binds to a pocket created by the TP53 Y220C mutation. Rezatapopt restores p53 tumor suppressor functions by stabilization of the p53 protein structure. Rezatapopt demonstrates tumor inhibition and regression in mouse models with established human tumor xenografts harboring the TP53 Y220C mutation[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PC14586. CAS No. 2636846-41-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156633. | |
| Rezetamig | Rezetamig is a human bispecific antibody that recognizes the CD3 antigen on T-lymphocytes and the CD22 antigen on mature and malignant B-lymphocytes[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ-75348780. CAS No. 2795115-07-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P990759. | |
| Rezivertinib | Rezivertinib (BPI-7711) is an orally active, highly selective and irreversible third-generation EGFR tyrosine kinase inhibitor (TKI). Rezivertinib exhibits high potency against the common activation EGFR and the resistance T790M mutations. Rezivertinib has excellent central nervous system (CNS) penetration and has antitumor activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BPI-7711. CAS No. 1835667-12-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-109189. | |
| Rezorstobart | Rezorstobart is an anti-KLRB1 human IgG1 κ monoclonal antibody[1]. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001). Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: IMT-009. CAS No. 2762201-86-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990760. | |
| Rezuforimod | Rezuforimod (AGN-232411; AG-80308) is an ophthalmic solution targeting the formyl peptide receptor (FPR) pathway. Rezuforimod exerts anti-inflammatory effects by targeting the formyl peptide receptor pathway. Administered topically, Rezuforimod significantly reduces the corneal conjunctival staining score and improves ocular discomfort symptoms, with no serious adverse events reported and favorable overall safety profile. Rezuforimod shows remarkable potential to serve as a novel therapeutic option for dry eye disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AGN-232411; AG-80308; AGN-411. CAS No. 1431754-15-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172435. | |
| RF9 | RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 876310-60-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-107382. | |
| (R)-Filanesib | (R)-Filanesib ((R)-ARRY-520) is the R-enantiomer of Filanesib (HY-15187). Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor with an IC50 of 6 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-ARRY-520. CAS No. 885060-08-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15187A. | |
| (R)-FL118 | (R)-FL118 (10,11-(Methylenedioxy)-20(R)-camptothecin) is the R-enantiomer of FL118 (HY-12486). (R)-FL118 shows anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 10,11-(Methylenedioxy)-20(R)-camptothecin. CAS No. 151636-76-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15792. | |
| RG100204 | RG100204 is a selective, orally available inhibitor of the aquaporin AQP9. RG100204 directly inhibits AQP9 channel function, preventing the transmembrane transport of water, glycerol, and H2O2. RG100204 reduces the activation of the NLRP3 inflammasome and p38 MAPK signaling pathways, thereby alleviating inflammation and pyroptosis. RG100204 reduces multi-organ dysfunction in a mouse sepsis model and shows glucose-regulating effects in diabetic db/db mice[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2140901-88-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161834. | |
| RG108 | RG108 (N-Phthalyl-L-tryptophan) is a non-nucleoside DNA methyltransferases (DNMTs) inhibitor (IC50=115 nM) that blocks the DNMTs active site. RG108 (N-Phthalyl-L-tryptophan) causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Phthalyl-L-tryptophan. CAS No. 48208-26-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13642. | |
| RG2833 | RG2833 is a brain-penetrant HDAC inhibitor with IC50s of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. The Ki values for HDAC1 and HDAC3 are 32 and 5 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RGFP109. CAS No. 1215493-56-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-16425. | |
| RG3039 | RG3039 (PF-06687859) is an orally active, blood-brain barrier-permeable DcpS inhibitor with an IC50 of 4.2 nM against hDcpS. RG3039 inhibits the decapping activity of DcpS and maintains DcpS in a catalytically inactive conformation in the central nervous system and other tissues. RG3039 extends survival and improves function in spinal muscular atrophy mice. RG3039 is applicable to research related to spinal muscular atrophy[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-06687859. CAS No. 1005504-62-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102020. | |
| RG7112 | RG7112 is a potent, selective, orally active and blood-brain barrier crossed MDM2-p53 inhibitor, with an IC50 of 18 nM and a KD of 11 nM for binding to MDM2[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RO5045337. CAS No. 939981-39-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10959. | |
| RG7834 | RG7834 (RO 7020322) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RO 7020322; (S)-RO0321. CAS No. 2072057-17-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-117650A. | |
| RGB-286638 | RGB-286638 is a CDK inhibitor that inhibits the kinase activity of cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5 with IC50s of 1, 2, 3, 4, 5 and 5 nM, respectively; also inhibits GSK-3β, TAK1, Jak2 and MEK1, with IC50s of 3, 5, 50, and 54 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 784210-87-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15504. | |
| RGD | RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins. Uses: Scientific research. Category: Signaling pathways. CAS No. 99896-85-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0278. | |
| RGD peptide (GRGDNP) | RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 114681-65-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1740. | |
| RGFP966 | RGFP966 is a highly selective HDAC3 inhibitor with an IC50 of 80 nM and shows no inhibition to other HDACs at concentrations up to 15 μM. RGFP966 can penetrate the blood brain barrier (BBB). Uses: Scientific research. Category: Signaling pathways. CAS No. 1357389-11-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13909. | |
| RGLS4326 | RGLS4326 (RG4326) is a first-in-class, short oligonucleotide inhibitor of microRNA-17 (miR-17). RGLS4326 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD). RGLS4326 inhibits miR-17 function in HeLa cells with an EC50 value of 28.3 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RG4326. CAS No. 2229964-07-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-139290. | |
| RGN6024 | RGN6024 is a brain-penetrant, orally active and reversible small molecule tubulin destabilizer. RGN6024 inhibits microtubule polymerization both in biochemical and cellular assays, binds to the colchicine binding pocket of β-tubulin (SPR: Kd = 6.7 μM; tryptophan assay: Kd = 7.4 μM), and triggers G2/M arrest in glioblastoma (GB) cells. RGN6024 retains activity in βIII-tubulin overexpressing cells. RGN6024 inhibits tumor growth in a GB xenograft mouse model. RGN6024 can be used for the study of glioblastoma (GB)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3055038-20-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-176537. | |
| (R)-GNE-140 | (R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC50s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R)-GNE-140 is 18-fold more potent than S enantiomer. Uses: Scientific research. Category: Signaling pathways. CAS No. 2003234-63-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100742A. | |
| (R)-(-)-Gossypol | (R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AT-101; R-(-)-gossypol acetic acid. CAS No. 90141-22-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-15464. | |
| (R)-GSK 2830371 | (R)-GSK 2830371 is the R-enantiomer of GSK 2830371 (HY-15832). GSK 2830371 is a highly selective Wip1 phosphatase inhibitor with IC50 of 6 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2743427-27-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15832A. | |
| (R)-GSK-3685032 | (R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2170140-50-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139664A. | |
| RGT-018 | RGT-018 is a potent and orally active SOS1 inhibitor with anti-tumor effects. RGT-018 exerts anti-cancer cell proliferation activity by inhibiting KRAS activation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2794934-49-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-163939. | |
| RGX-104 | RGX-104 is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Abequolixron. CAS No. 610318-54-2. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111498A. | |
| RH01386 | RH01386 is a small molecule that can prevent endoplasmic reticulum stress (ERS)-induced β cell dysfunction and death, and inhibits proapoptotic gene expression. RH01386 restores ERS-impaired glucose-stimulated insulin secretion responses. RH01386 has the potential for type 2 diabetes treatment[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 301177-36-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-124771. | |
| (R)-(+)-HA-966 | (R)-(+)-HA-966 ((+)-HA-966) is a partial agonist/antagonist of glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. (R)-(+)-HA-966 selectively blocks the activation of the mesolimbic dopamine system by amphetamine[1][2]. (R)-(+)-HA-966 can cross the blood-brain barrier and has the potential for neuropathic and acute pain[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-HA-966. CAS No. 123931-04-4. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100822. | |
| Rhamnetin | Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2 and histone deacetylase 2 (HDAC2). Rhamnetin exhibits antitumor, antioxidant and anti-inflammatory activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 90-19-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N7036. | |
| Rhapontigenin | Rhapontigenin is a natural analog of resveratrol with anticancer, antioxidant, antifungal and antibacterial activities. Rhapontigenin is amechanism-based, potent and selective cytochrome P450 1A1 inactivator (IC50 = 400 nM). Rhapontigenin exhibits 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 500-65-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N2229. | |
| Rhapontin | Rhapontin (Rhaponiticin) is an orally aactive SIRT1 agonist and AMPK activator with anti-inflammatory and anti-fibrotic activities. Rhapontin inhibits NLRP3 inflammasome activation by activating SIRT1 and inhibits TGF-β/Smad signaling via the AMPK pathway. Rhapontin reduces intestinal and lung inflammation, inhibits fibroblast differentiation and extracellular matrix deposition, and enhances tight junction protein expression to repair epithelial barriers. Rhapontin can be used in the study of inflammatory bowel diseases (such as ulcerative colitis) and pulmonary fibrosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Rhaponiticin. CAS No. 155-58-8. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg. Product ID: HY-N0671. | |
| Rhapontin (Standard) | Rhapontin (Standard) is the analytical standard of Rhapontin (HY-N0671). This product is intended for research and analytical applications. Rhapontin (Rhaponiticin) is an orally aactive SIRT1 agonist and AMPK activator with anti-inflammatory and anti-fibrotic activities. Rhapontin inhibits NLRP3 inflammasome activation by activating SIRT1 and inhibits TGF-β/Smad signaling via the AMPK pathway. Rhapontin reduces intestinal and lung inflammation, inhibits fibroblast differentiation and extracellular matrix deposition, and enhances tight junction protein expression to repair epithelial barriers. Rhapontin can be used in the study of inflammatory bowel diseases (such as ulcerative colitis) and pulmonary fibrosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Rhaponiticin (Standard). CAS No. 155-58-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0671R. | |
| [Rh(cod)Cl]2 | [Rh(cod)Cl]2 (Chloro(1,5-cyclooctadiene)rhodium(I) dimer) is a rhodium (I) organometallic dimer complex. [Rh(cod)Cl]2 can inhibit platelet-activating factor-mediated platelet aggregation with IC50 values of 5.2 and 43.3 μM in washed rabbit platelets and human platelet-rich plasmas. [Rh(cod)Cl]2 also can inhibit thrombin-, ADP (HY-W010918)- and collagen-induced aggregation with IC50 values of 16.7, 162 and 69.8 μM. [Rh(cod)Cl]2 can be used for the research of cardiovascular disease, such as thrombosis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Chloro(1,5-cyclooctadiene)rhodium(I) dimer. CAS No. 12092-47-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-Y1094. | |
| [Rh(Cp-)Cl2]2 | [Rh(Cp*)Cl2]2 is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pentamethylcyclopentadienylrhodium(III) chloride dimer. CAS No. 12354-85-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W019734. | |
| Rheb inhibitor NR1 | Rheb inhibitor NR1 is a Rheb inhibitor with an IC50 of 2.1?μM in the Rheb-IVK assay. Rheb inhibitor NR1 can directly bind Rheb in the switch II domain and selectively inhibit the activation of mechanistic target of rapamycin complex 1 (mTORC1). Rheb inhibitor NR1 inhibits the phosphorylation of mTORC1 driven T389pS6K1 and increases the phosphorylation of S473pAKT in a dose-dependent manner. Rheb inhibitor NR1 does not influence mTORC2 activity[1].(Rheb-IVK: Rheb-dependent mTORC1 kinase activity). Uses: Scientific research. Category: Signaling pathways. CAS No. 2216763-38-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124798. | |
| Rhein | Rhein is an anthraquinone compound with anti-inflammatory, antioxidant, and anti-cancer effects[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Rheic Acid; Rhubarb yellow; Monorhein. CAS No. 478-43-3. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g; 50 g; 100 g. Product ID: HY-N0105. | |
| Rhod-2 AM | Rhod-2 is a high-affinity visible light excitation wavelength Ca2+ fluorescent probe, Rhod-2, AM is an acetyl methyl ester derivative of Rhod-2, which has cell membrane permeability and can easily enter cells with simple culture. Once it enters the cell, it is sheared by its lactesterase to produce Rhod-2 without membrane permeability, which remains in the cell to perform the corresponding physiological functions. Maximum excitation/emission wavelength: 549/578 nm[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 145037-81-6. Pack Sizes: 50 μg; 1 mg. Product ID: HY-D0989. | |
| Rhodamine 123 | Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RH-123; R-22420. CAS No. 62669-70-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D0816. | |
| Rhodamine 3B perchlorate | Rhodamine 3B perchlorate is a laser dye. Uses: Scientific research. Category: Signaling pathways. CAS No. 23857-69-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1747. | |
| Rhodamine 6G | Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Basic Red 1. CAS No. 989-38-8. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 1 g; 5 g; 10 g. Product ID: HY-D0309. | |
| Rhodamine 800 | Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 137993-41-0. Pack Sizes: 10 mg; 25 mg. Product ID: HY-101876. | |
| Rhodamine B | Rhodamine B is a staining fluorescent dye, commonly used for dyeing textiles, paper, soap, leather, and agents. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Basic Violet 10; Brilliant Pink B; Rhodamine O; Tetraethylrhodamine. CAS No. 81-88-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 1 g. Product ID: HY-Y0016. | |
| Rhodamine B hydrazide | Rhodamine B hydrazide is a fluorescent derivative based on rhodamine B, containing the spirocyclic structure of Rhodamine B (HY-Y0016), which can be used to detect copper ions (Cu2+), mercury ions, peroxynitrite, hydroxyl radicals and nitric oxide (NO)[1][2][3].Excitation/emission wavelength:Conventional detection: 510/578 nm.Sulfite detection: 554 nm absorption, 574 nm emission (due to the formation of Rhodamine B fluorescent product). Uses: Scientific research. Category: Signaling pathways. CAS No. 74317-53-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123645. | |
| Rhodamine B isothiocyanate | Rhodamine B isothiocyanate (RBITC) is a fluorescent dye commonly used in biological imaging and labeling applications. It has an isothiocyanate functional group that can be covalently attached to amino groups on proteins and other biomolecules, making it useful for fluorescent labeling of cells and tissues. RBITC fluoresces bright orange-red under green light excitation, which makes it easy to detect and track labeled molecules in complex samples. Due to its stability and sensitivity, RBITC has been widely used in various research fields, including cell biology, immunology, and neurobiology. Uses: Scientific research. Category: Signaling pathways. CAS No. 36877-69-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112697. | |
| Rhodamine B NHS ester | Rhodamine B NHS ester (N-Hydroxysuccinimidyl rhodamine B ester) is an amine-reactive fluorescent probe (λex/λem: 564/589 nm, respectively). Rhodamine B NHS ester could react with Glycine (HY-Y0966)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Hydroxysuccinimidyl rhodamine B ester. CAS No. 144700-55-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-D2367. | |
| Rhodamine-N3 chloride | Rhodamine-N3 chloride is an azide-rhodamine fluorescent dye that can be used to label biomolecules containing alkyne groups[1][2]. Rhodamine-N3 chloride is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups (Ex/Em = 544/576 nm). Uses: Scientific research. Category: Signaling pathways. CAS No. 2363751-90-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D1269. | |
| Rhodionin | Rhodionin is an orally active, multifunctional antivirulence and cytoprotective agent that targets and inhibits Lipase, sortase A (SrtA), CYP2D6 (IC50=0.761 μM), AChE (IC50=2.43-57.5 μM), and DPPH free radicals (IC50=19.49 μM). Rhodionin is isolable from the roots of Rhodiola crenulata. Rhodionin reduces postprandial serum triglyceride levels in mice by inhibiting lipase activity. Rhodionin also binds directly to SrtA to inhibit its transpeptidase activity, thereby reducing the fibrinogen adhesion and surface protein A levels of MRSA, effectively inhibiting biofilm formation and protecting against MRSA-induced cell damage. Rhodionin improves the survival rate of infected mice without affecting MRSA growth, and finds wide application in studies related to hyperlipidemia, exogenous obesity, and pneumonia induced by methicillin-resistant Staphylococcus aureus (MRSA)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 85571-15-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N0241. | |
| Rhodium(III) oxide | Rhodium(III) oxide is an inorganic compound with catalytic activity. Rhodium(III) oxide can be used as an efficient catalyst in catalytic reactions and is often used to promote chemical reactions. Rhodium(III) oxide is also widely used in energy materials, especially in fuel cells and other renewable energy technologies. Rhodium(III) oxide is studied in the field of materials science for the development of new functional materials. Uses: Scientific research. Category: Signaling pathways. CAS No. 12036-35-0. Pack Sizes: 100 mg; 250 mg; 500 mg. Product ID: HY-W033823. | |
| Rhodizonic acid disodium | Rhodizonic acid disodium (Sodium rhodizonate dibasic) is a transition metal-dependent pro-oxidant and lead detection agent that induces reactive oxygen species generation, DNA damage, and inhibits Aconitase activity. Rhodizonic acid disodium generates superoxide anion radicals in an iron (II)-dependent manner, leading to aconitase inactivation. Rhodizonic acid disodium also triggers hydroxyl radical-mediated DNA strand breaks and 8-OHdG formation via copper ion reduction. Rhodizonic acid disodium reacts with lead to form a scarlet precipitate, with the color intensity proportional to lead content, enabling qualitative or quantitative analysis of lead. Rhodizonic acid disodium can also be used for real-time visualization of the dynamic process of lead sequestration in the plant rhizosphere and evaluation of the effects of environmental factors such as soil type on the stability of lead-sequestering structures[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Sodium rhodizonate dibasic. CAS No. 523-21-7. Pack Sizes: 5 g; 25 g; 50 g; 100 g. Product ID: HY-W115721. | |
| Rhodojaponin II | Rhodojaponin II is a diterpenoid from the leaves of Rhododendron molle with anti-inflammatory activity[1]. Uses: Scientific research. Category: Natural products. CAS No. 26116-89-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-N2151. | |
| Rhodojaponin III | Rhodojaponin III is a diterpenoid from the leaves of Rhododendron molle with anti-inflammatory activity[1]. Uses: Scientific research. Category: Natural products. CAS No. 26342-66-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N2152. | |
| Rhoifolin | Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 17306-46-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N0755. | |
| Rhombifoline | Rhombifoline is an alkaloid isolated for the first time from the leaves and stems of A. foetida L.[1]. Uses: Scientific research. Category: Natural products. CAS No. 529-78-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N7649. | |
| RhoNox-1 | RhoNox-1 is a fluorescent probe for the specific detection of divalent iron ions, and when RhoNox-1 reacts with Fe2+. RhoNox-1 can generate an irreversible orange (red) fluorescent product (Ex/Em?540/575 nm). FeRhoNox-1 can enter the cell well, suitable for the detection of Fe2+ in living cells, and tends to be localized in the Golgi apparatus[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1447815-38-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1533. | |
| Rhosin | Rhosin is a potent, specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin induces cell apoptosis[1][2]. Rhosin promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1173671-63-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-12646A. | |
| Rhosin hydrochloride | Rhosin hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride induces cell apoptosis[1][2]. Rhosin hydrochloride promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1281870-42-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12646. | |
| RHPS4 | RHPS4 is a potent telomerase inhibitor (IC50 = 0.33 μM). RHPS4 is a DNA damage inducer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 390362-78-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101089. | |
| (R)-HTS-3 | (R)-HTS-3 is an lysophosphatidylcholine acyltransferase 3 (LPCAT3) inhibitor, with an IC50 of 0.09 μM. (R)-HTS-3 suppresses the C20:4 content of PE, PC, and PS, while promoting a correspondingelevation in C22:4 phospholipids and a paradoxical increase in C20:4 phosphatidylinositol (PI) lipids[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2771208-83-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158790. | |
| RI-1 | RI-1 is a RAD51 inhibitor, with IC50s ranging from 5 to 30 μM. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319. RI-1 inactivates RAD51 by directly binding to a protein surface that serves as an interface between protein subunits in RAD51 filaments. RI-1 can disrupt homologous recombination in human cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 415713-60-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15317. | |
| RI-2 | RI-2 is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM, and specifically inhibits homologous recombination repair in human cells. Uses: Scientific research. Category: Signaling pathways. CAS No. 1417162-36-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16904. | |
| Ribavirin | Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV. Ribavirin also has anti-orthopoxvirus and anti-variola activities. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ribasphere. CAS No. 36791-04-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg. Product ID: HY-B0434. | |
| Ribavirin carboxylic acid | Ribavirin carboxylic acid (TR-COOH) is a metabolite of Ribavirin (HY-B0434), Ribavirin has strong antiviral activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 39925-19-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-145991. | |
| (R)-I-BET762 carboxylic acid | (R)-I-BET762 carboxylic acid, the R-enantiomer of I-BET762 carboxylic acid (HY-107443). I-BET762 carboxylic acid is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid is a BRD4 inhibitor with a pIC50 value of 5.1[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-Molibresib carboxylic acid; (R)-GSK525762A carboxylic acid; (R)-PROTAC BRD4-binding moiety 2. CAS No. 1786401-70-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107443A. | |
| Ribociclib | RRibociclib (LEE011) is an ATP-competitive and orally active CDK4/6 inhibitor that crosses the blood-brain barrier with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LEE011. CAS No. 1211441-98-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-15777. | |
| Ribociclib-d6 | Ribociclib-d6 (LEE011-d6) is a deuterium labeled Ribociclib (HY-15777). Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LEE011-d6. CAS No. 1328934-40-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-15777S. | |
| Ribociclib-d8 | Ribociclib-d8 is the deuterium labeled Ribociclib[1]. Ribociclib (LEE01) is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LEE011-d8. CAS No. 2167898-24-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-15777S1. | |
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