MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| QX-314 bromide | QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 24003-58-5. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-101350. |  |
| QX-314 chloride | QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 5369-3-9. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-108505. | |
| QX77 | QX77 is a chaperone-mediated autophagy (CMA) activator and upregulates LAMP2A expression in vitro. QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells[1]. QX77 can impede self-renewal and promote differentiation of ES cells[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1798331-92-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112483. | |
| (R)-[1,1'-Binaphthalene]-2,2'-diamine | (R)-[1,1'-Binaphthalene]-2,2'-diamine is the isomer of (S)-[1,1'-Binaphthalene]-2,2'-diamine (HY-W007978A), and can be used as an experimental control. (S)-[1,1'-Binaphthalene]-2,2'-diamine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R-(-)-2,2-Diamino-1,1-binaphthyl. CAS No. 18741-85-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g; 25 g. Product ID: HY-W007978. | |
| R121919 | R121919 (NBI30775) is a potent and selective CRF1R antagonist with a Ki of 2 to 5 nM. R121919 has antidepressant and anxiolytic effects. R121919 alleviates defensive withdrawal in rats[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NBI30775. CAS No. 195055-03-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14127. | |
| R-1479 | R-1479 (4'-Azidocytidine), a nucleoside analogue, is a specific inhibitor of RNA-dependent RNA polymerase (RdRp) of HCV. R-1479 inhibits HCV replication in the HCV subgenomic replicon system (IC50=1.28 μM)[1][2][3]. R-1479 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4'-Azidocytidine. CAS No. 478182-28-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10444. | |
| R162 | R162 is a potent inhibitor of glutamate dehydrogenase 1 (GDH1/GLUD1), with anti-cancer properties. Uses: Scientific research. Category: Signaling pathways. CAS No. 64302-87-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103096. | |
| R1-ICR-5 | R1-ICR-5 is a highly selective RIPK1 PROTAC degrader. Mediated by VHL, R1-ICR-5 induces the degradation of RIPK1, which in turn dysregulates the TNFR1 and TLR3/4 signaling hubs, enhances the signaling outputs of NF-κB, MAPK and IFN, and simultaneously promotes RIPK3 activation and necroptosis (necroptosis). R1-ICR-5 can be used in the research of triple-negative breast cancer and skin inflammation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3070346-91-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-171658. | |
| R-1 Methanandamide Phosphate | R-1 Methanandamide Phosphate is a water-soluble prodrug analog of arachidonylethanolamide (AEA). AEA is an endogenous cannabinoid compound[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 649569-33-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-126719. | |
| (R)-1-PeCSO | (R)-1-PeCSO (trans-(+)-S-1-Propenyl-L-cysteine sulfoxide) is the most abundant flavor precursor in onions[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Isoalliin; trans-(+)-S-1-Propenyl-L-cysteine sulfoxide. CAS No. 16718-23-3. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg. Product ID: HY-111825A. | |
| (R)-2-(3-(2-Ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic Acid | (R)-2-(3-(2-Ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic Acid is an intermediate in the synthesis of the diacylglycerol acyltransferase 2 (DGAT-2) inhibitor Ervogastat. Uses: Scientific research. Category: Signaling pathways. CAS No. 1809064-89-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-169499. | |
| R-268712 | R-268712 is an orally active and selective ALK-5 inhibitor, with an IC50 of 2.5 nM. R-268712 inhibits the phosphorylation of Smad3 in a dose-dependent manner with an IC50 of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-β signaling, which can be used in studies of renal fibrosis and cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 879487-87-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12953. | |
| (R)-(-)-2-Butanol | (R)-(-)-2-Butanol is the isomer of 2-Butanol, which is found in the females of the white grub beetle, Dasylepida ishigakiensis, to attract males. (R)-(-)-2-Butanol is an intermediate of pharmaceutical synthesis by coupling[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 14898-79-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g. Product ID: HY-W087952. | |
| (R)-2-Hydroxybutanoic acid | (R)-2-Hydroxybutanoic acid is the isomer of 2-Hydroxybutyric acid (HY-113381), and can be used as an experimental control. 2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-α-Hydroxybutyric acid. CAS No. 20016-85-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-113381A. | |
| (R)-3-Hydroxybutanoic acid | (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-(-)-3-Hydroxybutanoic acid; (R)-3-Hydroxybutyric acid. CAS No. 625-72-9. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-W051723. | |
| (R)-3-Hydroxybutanoic acid-13C4 sodium | (R)-3-Hydroxybutanoic acid-13C4 sodium is a 13C labeled (R)-3-Hydroxybutanoic acid (HY-W051723). (R)-3-Hydroxybutanoic acid is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-(-)-3-Hydroxybutanoic acid-13C4 sodium; (R)-3-Hydroxybutyric acid-13C4 sodium. CAS No. 2483735-72-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W015851S2. | |
| (R)-3-Hydroxybutanoic acid sodium | (R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-(-)-3-Hydroxybutanoic acid sodium; (R)-3-Hydroxybutyric acid sodium. CAS No. 13613-65-5. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-W015851. | |
| R406 | R406 is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 reduces immune complex-mediated inflammation[1]. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 841290-81-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12067. | |
| R406 free base | R406 free base is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 free base reduces immune complex-mediated inflammation[1]. R406 free base also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 841290-80-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-11108. | |
| R547 | R547 is a potent, selective and orally active ATP-competitive CDK inhibitor, with Kis of 2 nM, 3 nM and 1 nM for CDK1/cyclin B, CDK2/cyclin E and CDK4/cyclin D1, respectively[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 741713-40-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10014. | |
| R 59-022 | R 59-022 (DKGI-I) is a DGK inhibitor (IC50: 2.8 μM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DKGI-I; Diacylglycerol kinase inhibitor I. CAS No. 93076-89-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107613. | |
| R59949 | R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC50 of 300 nM. R59949 strongly inhibits the activity of type I DGK α and γ and moderately attenuates the activity of type II DGK θ and κ. R59949 activates protein kinase C (PKC) by enhancing the levels of the endogenous ligand diacyl glycerol[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 120166-69-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108355. | |
| R-6890 | R-6890 is a Brorphine-related opioid receptor antagonist that exhibits differential binding activities toward rat opioid receptors (IC50=4.6 nM (0.05 M Tris; pH 7.4) and 170 nM (0.05 M Tris+0.1 M NaCl)). R-6890 displaces bound labeled opioids from receptors, and its binding affinity is affected by environmental factors, decreasing in the presence of NaCl. R-6890 crosses the blood-brain barrier (BBB) and exerts analgesic effects in the warm water-induced tail-flick reflex model of male Wistar rats[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3222-88-6. Pack Sizes: 10 mg; 100 mg. Product ID: HY-168366. | |
| R-7050 | R-7050 (TNF-α Antagonist III) is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TNF-α Antagonist III. CAS No. 303997-35-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110203. | |
| (R)-9b | (R)-9b is a potent inhibitor of ACK1 tyrosine kinase (IC50=56 nM) with anticancer activity. (R)-9b exhibits selectivity for ACK1 but has inhibitory effects on JAK family kinases JAK2 and Tyk2. (R)-9b can be used in the study of hormone-regulated cancers such as prostate and breast cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1655527-68-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113787. | |
| RA-0002034 | RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with an IC50 of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RA-2034. CAS No. 3038542-51-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161762. | |
| RA190 | RA190, a bis-benzylidine piperidon, inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13. Uses: Scientific research. Category: Signaling pathways. CAS No. 1617495-03-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100739. | |
| RA375 | RA375 is a RPN13 (26S proteasome regulatory subunit) inhibitor. RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater activity against cancer lines than RA190, reflecting its nitro ring substituents and the addition of a chloroacetamide warhead[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2649154-57-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-136563. | |
| RA839 | RA839 is a selective Nrf2/ARE pathway agonist and non-covalent small molecule binder of Keap1 (Kd is approximately 6 μM). RA839 prevents inducible nitric oxide synthase expression and nitric oxide release. RA839 exerts anti-rotaviral and anti-inflammatory effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1832713-02-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110275. | |
| Rabacfosadine | Rabacfosadine (GS-9219), a novel proagent of the nucleotide analogue PMEG, is designed as a cytotoxic agent that preferentially targets lymphoid cells. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GS-9219; VDC-1101. CAS No. 859209-74-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13640. | |
| Rabdosiin | Rabdosiin ((+)-Rabdosiin) is a Caffeic acid (HY-N0172) tetramer. Rabdosiin can be isolated from Macrotomia euchroma[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Rabdosiin. CAS No. 263397-69-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N6880. | |
| Rabeprazole | Rabeprazole (LY307640) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole induces apoptosis. Rabeprazole acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY307640. CAS No. 117976-89-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0656. | |
| Rabusertib | Rabusertib (LY2603618) is a potent and selective inhibitor of Chk1 with an IC50 of 7 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY2603618; IC-83. CAS No. 911222-45-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14720. | |
| (Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium | (Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is an anionic phospholipid, can be studied for drug delivery and the synthesis of liposomes. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-containing liposomes can induce Tregs that are specific for the liposomes cargo. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is taken up by antigen-presenting cells mediated via complement component 1q (C1q)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 124011-52-5. Pack Sizes: 50 mg; 100 mg. Product ID: HY-112307A. | |
| Rac1-IN-5 | Rac1-IN-5 is a specific, reversible inhibitor of RAC1 (KD = 30 nM). Rac1-IN-5 competes with guanine nucleotides for specific binding to RAC proteins, effectively blocking RAC1 activity and RAC1-dependent cellular functions. Rac1-IN-5 exhibits anti-tumor metastasis effects in vivo and can improve survival. Rac1-IN-5 can be used to study invasive cancers such as triple-negative breast cancer and colon cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 694515-65-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175341. | |
| (Rac)-1-Oleoyl lysophosphatidic acid sodium | (Rac)-1-Oleoyl lysophosphatidic acid ((Rac)-1-Oleoyl-sn-glycero-3-phosphate) sodium is the racemic isomer of 1-Oleoyl lysophosphatidic acid sodium (HY-107614)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (Rac)-1-Oleoyl-sn-glycero-3-phosphate sodium; (Rac)-1-Oleoyl-LPA sodium. CAS No. 22556-62-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-107501. | |
| (rac)-3-O-Methyl DOPA-d3 | (rac)-3-O-Methyl DOPA-d3 is the deuterium labeled (rac)-3-O-Methyl DOPA[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1219173-95-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-132404S. | |
| (Rac)-Acolbifene | (Rac)-Acolbifene (EM-343; (Rac)-EM-652) is the racemic form of EM652 (estrogen receptor?antagonist), has anti-estrogenic and estrogenic activities. (Rac)-Acolbifene (EM-343; (Rac)-EM-652) contains a piperidine ring, shows good pharmacological profile,relative binding affinity (RBA)=380[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EM-343; (Rac)-EM-652. CAS No. 151533-34-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16023B. | |
| (rac)-AR-13503 | (rac)-AR-13503 ((rac)-AR-13324 M1 metabolite) is the isoform of AR-13503 (HY-12798C). AR-13503 a ROCK/PKC inhibitor, inhibiting angiogenesis and enhancing retinal pigment epithelium (RPE) permeability. AR-13503 also inhibits the formation of aberrant neovascularization (NV) in oxygen-induced retinopathy (OIR) model in mice[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (rac)-AR-13324 M1 metabolite. CAS No. 1254032-16-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125639. | |
| (Rac)-Atropine-d3 | (Rac)-Atropine-d3 is the deuterium labeled (Rac)-Atropine[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (Rac)-Tropine tropate-d3; (Rac)-Hyoscyamine-d3. CAS No. 1276197-36-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B1205S. | |
| (Rac)-BAY1238097 | (Rac)-BAY1238097 is a BET inhibitor, with an IC50 of 1.02 μM for BRD4. Used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1564268-19-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112316B. | |
| (Rac)-Bedaquiline-d6 | (Rac)-Bedaquiline-d6 is the deuterium labeled Bedaquiline (HY-14881)[1]. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit[2]. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2517573-53-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-14881S1. | |
| rac-BHFF | rac-BHFF is a potent and orally active allosteric enhancer of GABAB receptor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 123557-91-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103519. | |
| Racecadotril | Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with Kis of 4500 and 6.1 nM, , respectively. Antidiarrheal agent[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Acetorphan. CAS No. 81110-73-8. Pack Sizes: 10 mM * 1 mL in DMSO; 200 mg; 500 mg; 1 g. Product ID: HY-17399. | |
| (Rac)-Finerenone | (Rac)-Finerenone ((Rac)-BAY 94-8862) is the racemate of Finerenone. Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (Rac)-BAY 94-8862. CAS No. 1050477-27-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-111372A. | |
| (Rac)-Ibrutinib alkyne | (Rac)-Ibrutinib alkyne (Compound 8) is a Btk inhibitor with an IC50 of 0.72 nM. (Rac)-Ibrutinib alkyne can effectively inhibit functions related to the B-cell receptor signaling pathway, with an IC50 of 9 nM for inhibiting Ca flux in Ramos cells. (Rac)-Ibrutinib alkyne can be used in the research of diseases such as rheumatoid arthritis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 936563-91-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15809. | |
| (Rac)-Juvenile Hormone III-d3 | Juvenile Hormone III-d3 is the deuterium labeled Juvenile Hormone III. (Rac)-Juvenile Hormone III is a cecropia juvenile hormone and juvenile hormone agonist. (Rac)-Juvenile Hormone III induces test insects to retain larval characteristics after the final molt to the adult stage. (Rac)-Juvenile Hormone III exhibits juvenile hormone activity in Tenebrio molitor pupae and last-instar nymphs of Oncopeltus fasciatus. (Rac)-Juvenile Hormone III possesses morphogenetic activity in insect assays[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 951116-89-5. Pack Sizes: 2.5 mg. Product ID: HY-N7240S. | |
| (Rac)-LM11A-31 dihydrochloride | (Rac)-LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride. LM11A-31 dihydrochloride, a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1214672-15-7. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg. Product ID: HY-110155A. | |
| Raclopride | Raclopride is a dopamine D2/D3 receptor antagonist with potential antipsychotic effects. Raclopride binds to D2 and D3 receptors with Kis of 1.8 nM and 3.5 nM, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 84225-95-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103414. | |
| (Rac)-LRK-4189 | (Rac)-LRK-4189 is the racemate of LRK-4189 (HY-175751). Uses: Scientific research. Category: Signaling pathways. CAS No. 3063345-48-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175751A. | |
| (rac)-Metanephrine-d3 hydrochloride | (rac)-Metanephrine-d3 (hydrochloride) is the deuterium labeled (rac)-Metanephrine hydrochloride[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1215507-88-2. Pack Sizes: 5 mg. Product ID: HY-W012206S. | |
| (Rac)-NSC305787 | NSC305787 is an inhibitor of ezrin with a Kd of 5.85 μM, inhibits the phosphorylation of ezrin caused by PKC&Lota; with an IC50 of 8.3 μM, has antitumor activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 785718-37-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18931. | |
| (Rac)-OSMI-1 | (Rac)-OSMI-1 is the racemate of OSMI-1. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2748153-92-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-119738A. | |
| (Rac)-SHIN2 | (Rac)-SHIN2 is a pyrazolopyran derivative and a serine hydroxymethyltransferase (SHMT) inhibitor. (Rac)-SHIN2 has antibacterial activity and low cytotoxicity against Hep2 cells. (Rac)-SHIN2 exerts potent antibacterial activity against both vancomycin-susceptible and vanA-type vancomycin-resistant Enterococcus[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2204289-53-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134978. | |
| (Rac)-sn-Glycerol 3-phosphate sodium | (Rac)-sn-Glycerol 3-phosphate sodium is an a-site substrate analogue. (Rac)-sn-Glycerol 3-phosphate sodium is bound to the a-site, the rate of reaction of indole and nucleophilic indole analogues with E(A-A) is strongly inhibited[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DL-α-Glycerol phosphate sodium. CAS No. 1555-56-2. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-108776. | |
| (Rac)-TBAJ-876 | (Rac)-TBAJ-876 is a racemate of TBAJ-876. TBAJ-876 is the inhibitor of mycobacterium tuberculosis. TBAJ-876 is the analogue of the anti-tuberculosis agent Bedaquiline (HY-14881). TBAJ-876 has the potential for the research of tuberculosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2131784-39-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128866A. | |
| (Rac)-Tenofovir-d6 | (Rac)-Tenofovir-d6 is a labelled racemic Tenofovir. Tenofovir (GS 1278) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B (HBV)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1020719-94-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-113904S. | |
| (Rac)-Timolol-d5 maleate | rac Timolol-d5 (maleate) is a labelled racemic (S)-Timolol maleate. (S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (Rac)-L-714,465 maleate; (Rac)-MK 950-d5. CAS No. 1217260-21-3. Pack Sizes: 1 mg. Product ID: HY-17494S. | |
| RAD51-IN-1 | RAD51-IN-1, a derivative of B02, is a potent inhibitor of RAD51. RAD51-IN-1 can be used for cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2101739-18-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122705. | |
| RAD51 Inhibitor B02 | RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: B02. CAS No. 1290541-46-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101462. | |
| Raddeanin A | Raddeanin A is an oleanane-type triterpenoid saponin with oral activity. Raddeanin A inhibits SRC, mTOR, JNK, VEGFR2, NLRP3 inflammasome, Wnt/β-catenin, Wee1, PI3K/AKT signaling pathway, MAPK/ERK signaling pathway, AR-FL, AR-Vs, and downregulates the expression of p-PI3K and p-AKT. Raddeanin A inhibits osteoclast formation, bone resorption, osteolysis, cancer cell invasion, migration, proliferation, angiogenesis and epithelial-mesenchymal transition, while induces apoptosis, cell cycle arrest, ROS production, immunogenic cell death and dendritic cell maturation. Raddeanin A improves blood-retinal barrier function, alleviates inflammation, regulates the tumor microenvironment, and enhances the activity of anti-PD-1 antibody. Raddeanin A is applicable to the research of breast cancer-associated osteolysis, human osteosarcoma, colorectal cancer, glioblastoma, Alzheimer's disease, cholangiocarcinoma, melanoma, non-small cell lung cancer, castration-resistant prostate cancer and multiple myeloma[1][2][3][4][5][6][7][8][9][10][11]. Uses: Scientific research. Category: Signaling pathways. CAS No. 89412-79-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0819. | |
| Rademikibart | Rademikibart (CBP-201) is a human monoclonal antibody targeting IL-4Rα and IL-4Rα inhibitor with a KD of 20.7 pM when binding to human IL-4Rα epitopes. Rademikibart does not bind to IL-4Rα from other species. Rademikibart inhibits IL-4 and IL-13-mediated STAT6 signaling, TF-1 cell proliferation and thymus activation regulated chemokine (TRAC) production. Rademikibart can be used for the research of atopic dermatitis and asthma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CBP-201. CAS No. 2648260-80-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990090. | |
| Radicicol | Radicicol is an inhibitor of Hsp90 with an IC50 value < 1 μM, and leads to proteasomal degradation[1]. Radicicol exhibits inhibition on PDK with IC50s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB[2]. Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC50 value of 16.04 μM[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Monorden. CAS No. 12772-57-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N6769. | |
| Radioprotectin-1 | Radioprotectin-1 is a potent and specific nonlipid agonist of lysophosphatidic acid receptor 2 (LPA2), with an EC50 value of 25 nM for murine LPA2 subtype[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1622006-09-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-114380. | |
| Radiprodil | Radiprodil (RGH-896) is an orally active and selective NMDA NR2B antagonist. A potential therapeutic agent in treatment of neuropathic pain and possibly other chronic pain conditions[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RGH-896. CAS No. 496054-87-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14777. | |
| Radotinib | Radotinib (IY-5511) is an orally active and BBB-permeable selective tyrosine kinase Bcr-Abl1 inhibitor with an IC50 of 34 nM. Radotinib has anti-prion and anti-tumor activities. Radotinib can inhibit the proliferation, induce cell cycle arrest and apoptosis of tumor cells. Radotinib can be used in the research of cancer such as chronic myeloid leukemia and multiple myeloma, as well as neurodegenerative diseases such as prion diseases[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IY-5511. CAS No. 926037-48-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15728. | |
| RAF265 | RAF265 is a potent and orally active RAF/VEGFR2 inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CHIR-265. CAS No. 927880-90-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10248. | |
| RAF709 | RAF709 is a potent, selective, and efficacious RAF inhibitor with IC50s of 0.4 nM and 0.5 nM for BRAF and CRAF, respectively[1]. Antitumor efficacy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1628838-42-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100510. | |
| Rafivirumab | Rafivirumab (CR57) is an anti-rabies virus monoclonal antibody for the prophylaxis of rabies. Rafivirumab has neutralizing potency against a broad spectrum of RABV variants. Rafivirumab can be used for research of cocktails[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CR57. CAS No. 944548-37-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99811. | |
| Rafoxanide | Rafoxanide is a poent, orally active halogenated salicylaniline agent with antiparasitic activity. Rafoxanide interferes with energy metabolism in trematodes by uncoupling oxidative phosphorylation. Rafoxanide is also found to be a potent inhibitor of the BRAF V600E mutant protein, which is important in colorectal cancer. Rafoxanide can be used for the control of infestation with Hemonchus species or Fasciola species in sheep and cattle as well as Oestrus ovis in sheep. Rafoxanide can also be used for cancer research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 22662-39-1. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-17598. | |
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