MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| PRT4165 | PRT4165 is a potent inhibitor of polycomb-repressive complex 1 (PRC1)-mediated H2A ubiquitylation. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC600157. CAS No. 31083-55-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19817. |  |
| Prucalopride | Prucalopride is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 179474-81-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14151. | |
| Prucalopride succinate | Prucalopride succinate is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride succinate improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride succinate also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride succinate can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R-108512. CAS No. 179474-85-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-12694. | |
| Prulifloxacin | Prulifloxacin (NM441) is an orally active fluoroquinolone antibiotic with a broad spectrum of activity against Gram-positive and -negative bacteria. Prulifloxacin is a proagent of a thiazeto-quinoline carboxylic acid derivative Ulifloxacin (NM394). Prulifloxacin has the potential for lower urinary tract infections and exacerbations of chronic bronchitis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NM441. CAS No. 123447-62-1. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0024. | |
| Prunetin | Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 552-59-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N2597. | |
| Prunetrin | Prunetrin (Trifoside) is a flavonoid identified as a potential anti-prostate cancer agent in in silico screening[2]. Uses: Scientific research. Category: Natural products. Alternative Names: Trifoside; Prunetin 4-O-β-D-glucopyranoside. CAS No. 154-36-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-N7645. | |
| Prunin | Prunin is a potent inhibitor of human enterovirus A71 (HEVA71). Prunin shows strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), with an IC50 of 5.5 μM[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Naringenin 7-0-glucoside. CAS No. 529-55-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N1549. | |
| Prussian blue insoluble | Prussian blue soluble is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue soluble has anticancerous and antibacterial properties. Prussian blue soluble can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Iron(III) ferrocyanide; Milori blue. CAS No. 14038-43-8. Pack Sizes: 10 g; 25 g; 50 g; 100 g; 250 g. Product ID: HY-106594A. | |
| Prussian blue soluble | Prussian blue soluble is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue soluble has anticancerous and antibacterial properties. Prussian blue soluble can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pigment blue 27. CAS No. 12240-15-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-106594B. | |
| Pruvanserin | Pruvanserin (EMD 281014 free base) is a selective 5-HT2A receptor antagonist. Pruvanserin alleviates tactile allodynia in diabetic rats. Pruvanserin can also be used for research of insomnia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EMD 281014 free base; LY 2422347. CAS No. 443144-26-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106246. | |
| PRX-08066 | PRX-08066 is a selective and orally active 5-hydroxytryptamine receptor 2B (5-HT2BR) antagonist with a Ki of 3.4 nM. PRX-08066 inhibits the MAPK pathway, 5-HT release and fibrotic factor (TGFβ1, CTGF and FGF2) expression. PRX-08066 inhibits the proliferation of KRJ-I cells and induces apoptosis (caspase-3 activation). PRX-08066 inhibits pulmonary vascular remodeling. PRX-08066 can be used of pulmonary Arterial Hypertension (PAH) and neuroendocrine tumor (NET)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 866206-54-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15472. | |
| Przewaquinone A | Przewaquinone A, a lipophilic diterpene quinone present only in Salvia przewalskii, induces a potent inhibitory action on vascular contraction[1]. Uses: Scientific research. Category: Natural products. CAS No. 76843-23-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N1551. | |
| PS10 | PS10 is a novel, potent and ATP-competitive pan-PDK inhibitor, inhibits all PDK isoforms with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 (Kd= 239 nM) than for Hsp90 (Kd= 47 μM)[1]. PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy[2].PDK: pyruvate dehydrogenase kinase. Uses: Scientific research. Category: Signaling pathways. CAS No. 1564265-82-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121744. | |
| PS-1145 | PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 431898-65-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18008. | |
| PS372424 hydrochloride | PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1596362-29-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111149A. | |
| PS48 | PS48 is an activator of PDK1 with an AC50 of 8 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1180676-32-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15967. | |
| Psammaplin A | Psammaplin A is a marine metabolite. Psammaplin A is a selective HDAC1 (IC50: 45 nM), DNA methyltransferases (IC50: 18.6 nM) and aminopeptidase N (APN) (IC50: 18 μM) inhibitor. Psammaplin A also inhibits DNA topoisomerase and farnesyl protein transferase. Psammaplin A is a PPARγ activator and induces apoptosis. Psammaplin A has antitumor and anti-inflammatory activities. Psammaplin A has antibacterial activity against Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Psammaplin A inhibits angiogenesis[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. CAS No. 110659-91-1. Pack Sizes: 100 μg; 1 mg. Product ID: HY-N2150. | |
| PSB-0739 | PSB-0739 is a high-affinity potent, competitive, nonselective platelet P2Y12 receptor antagonist with a Ki values of 24.9 nM. The P2Y12 receptor plays a crucial role in platelet aggregation. Antithrombotic effect[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1052087-90-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108660. | |
| PSB-1115 | PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 152529-79-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103182. | |
| PSB-12054 | PSB-12054 is a selective P2X4 antagonist with an IC50 of 0.189 μM at human P2X4 receptors. PSB-12054 can be used in the research of neuropathic pain and neurodegenerative diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1407632-07-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101228. | |
| PSB-12062 | PSB-12062 is a potent and selective P2X4 antagonist with an IC50 of 1.38 μM for human P2X4. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-(p-Methylphenylsulfonyl)phenoxazine. CAS No. 55476-47-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101910. | |
| PSB-12379 | PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1802226-78-3. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg. Product ID: HY-100747. | |
| PSB-1901 | PSB-1901 is a potent A2B adenosine receptor (A2BAR) antagonist with Kis of 0.0835 nM and 0.131 nM for human and mouse A2BARs respectively. PSB-1901 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2332835-02-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-153897. | |
| PSB-603 | PSB-603 is a potent and highly selective A2B adenosine receptor antagonist exhibiting a Ki value of 0.553 nM and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1092351-10-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103166. | |
| PSB-CB5 | PSB-CB5 is a potent and selective antagonist of GRP18. PSB-CB5 has the potential for the research of metabolic disease and obesity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1627710-30-8. Pack Sizes: 1 mg. Product ID: HY-44154. | |
| PSB-KK1415 | PSB-KK1415 is a selective agonist for human orphan G protein-coupled receptor GPR18, with EC50 of 19.1 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 885896-26-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162617. | |
| PSB-KK1445 | PSB-KK1445 is a potent and selective GPR18 agonist with EC50s of 45.4 nM and 124 nM for human and mouse GPR18, respectively. PSB-KK1445 displays >200-fold selectivity versus both CB receptor subtypes, GPR55, and GPR183[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 885896-54-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162618. | |
| p-SCN-Bn-deferoxamine | P-SCN-Bn-deferoxamine is a bifunctional chelating agent that can link radioactive metal nuclides (such as Zr-89) and biological targeting molecules (such as antibodies). P-SCN-Bn-deferoxamine can be used for the research of immune PET imaging[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1222468-90-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134797. | |
| p-SCN-Bn-DOTA | p-SCN-Bn-DOTA is a bifunctional chelating agent. p-SCN-Bn-DOTA can simultaneously chelate radionuclides and link monoclonal antibody for radioimmunoresearch of tumor[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 127985-74-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114377. | |
| p-SCN-Bn-NOTA trihydrochloride | p-SCN-Bn-NOTA trihydrochloride is a macrocyclic chelator. p-SCN-Bn-NOTA trihydrochloride can be covalently coupled to molecules such as peptides through the thiocyanate group to form hexacoordinate copper (such as 64Cu) complexes. p-SCN-Bn-NOTA trihydrochloride specifically binds to GRPR or EGFR highly expressed on the surface of tumor cells, mediating tumor enrichment of radioactive probes. p-SCN-Bn-NOTA trihydrochloride can be used to study malignant tumors expressing GRPR or EGFR, such as prostate cancer and colorectal cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1583289-85-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-W782083. | |
| p-SCN-Bn-TCMC | p-SCN-Bn-TCMC is a bifunctional chelator. Its cyclen backbone binds Hg2+, while its isothiocyanate group allows for conjugation to biomolecules. p-SCN-Bn-TCMC can be used in the research of prostate cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 282097-63-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-201263. | |
| PSEM 89S TFA | PSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1336913-03-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112217A. | |
| Pseudoisocyanine iodide | Pseudoisocyanine iodide (1,1'-Diethyl-2,2'-cyanine iodide) is an inhibitor of organic cation transporters (OCT1, OCT2, OCT3) and plasma membrane monoamine transporter (PMAT). Pseudoisocyanine iodide has antidepressant activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 1,1'-Diethyl-2,2'-cyanine iodide; Decynium 22; Diethylcyanine iodide; Eastman 7851. CAS No. 977-96-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-107740. | |
| Pseudomonas quinolone signal | Pseudomonas quinolone signal (PQS) is a quorum-sensing signaling molecule produced by Pseudomonas aeruginosa. The synthesis of Pseudomonas quinolone signal relies on the las quorum-sensing system, and its biological activity is associated with the rhl system. Pseudomonas quinolone signal regulates the expression of the virulence gene lasB. Additionally, Pseudomonas quinolone signal plays roles in iron acquisition, cytotoxicity, outer-membrane vesicle biogenesis, and host immune modulation[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PQS. CAS No. 108985-27-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128200. | |
| Pseudotaraxasterol | Pseudotaraxasterol shows cytotoxic activity against MOLT-4 cells. Uses: Scientific research. Category: Signaling pathways. CAS No. 464-98-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N1555. | |
| Pseudouridimycin | Pseudouridimycin (PUM) is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PUM. CAS No. 1566586-52-4. Pack Sizes: 1 mg. Product ID: HY-125650. | |
| Pseudouridine | Pseudouridine is an isomer of uridine and the most abundant modified nucleoside in non-coding RNA. It fine-tunes and stabilizes regional structures in rRNA and tRNA, maintaining their functions in mRNA decoding, ribosome assembly, processing, and translation.Pseudouridine-modified tRNA fragments can inhibit aberrant protein synthesis and hold promise for research on myelodysplastic syndrome (MDS)-related leukemia.[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1445-07-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113061. | |
| PSI-697 | PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: P-Selectin Inhibitor. CAS No. 851546-61-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15526. | |
| PSI-7409 tetrasodium | PSI-7409 tetrasodium is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), inhibiting HCV NS5B polymerases, with IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1621884-22-7. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-15745A. | |
| PSMA-11 | PSMA-11 is a small molecule ligand that targets prostate-specific membrane antigen (PSMA) and has the ability to inhibit PSMA activity. PSMA-11 can be used to synthesize 68Ga-PSMA-11, a positron emission tomography (PET) tracer that can be used to image advanced prostate cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HBED-CC-PSMA. CAS No. 1366302-52-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125399. | |
| PSMA-ALB-56 | PSMA-ALB-56 is a PSMA-targeting radioligand designed by combining the glutamate-urea PSMA-binding entity and an albumin binder[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2306049-48-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-141536. | |
| PSMA-azide | PSMA-azide is a prostate-specific membrane antigen (PSMA) ligand. PSMA-azide inhibits PSMA-dependent NAAG (N-acetylaspartylglutamic acid) hydrolysis, with an IC50 of 9 nM and a Ki of 1 nM. PSMA-azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2374814-84-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-160893. | |
| PSMA-BCH | PSMA-BCH (NOTA-PSMA) is a NOTA-conjugated precursor. NOTA is a bifunctional chelate which acts as the framework to construct PET imaging tools[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NOTA-PSMA. CAS No. 1703768-73-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-155483. | |
| PSMA binder-1 | PSMA binder-1 is a ligand for PSMA and can be used to synthesize PSMA targeting molecule, such as Ac-PSMA-trillium[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2170653-14-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158123. | |
| PSMA I&S | PSMA I&S is a precursor of the 99mTc-labeled PSMA-targeting ligand[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2639475-07-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-148152. | |
| PSMα2 | PSMα2 is a potent PSM (phenol-soluble modulin) peptide toward mouse neutrophils, led to strong influx of leukocytes[1]. Uses: Scientific research. Category: Peptides. CAS No. 1092844-32-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10629. | |
| PSMα3 | PSMα3 is an inhibitor of NF-κB p65 and p38 MAPK. PSMα3 forms membrane pores and binds to residues of human insulin B chain to inhibit insulin aggregation. PSMα3 forms α-type amyloid-like fibrils to exert cytotoxic effects, and acts as a functional amyloid virulence determinant of Staphylococcus aureus. PSMα3 is applicable to research related to spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and Staphylococcus aureus infection[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1001405-52-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2358. | |
| PSMA-Val-Cit-PAB-MMAE | PSMA-Val-Cit-PAB-MMAE is a small-molecule conjugate targeting PSMA, with Monomethyl auristatin E (MMAE) (HY-15162) as its cytotoxic payload. PSMA-Val-Cit-PAB-MMAE binds to PSMA, thereby being delivered into PSMA-expressing prostate cancer cells. Subsequently, the Val-Cit linker is cleaved under the mediation of cathepsin B, releasing active MMAE. PSMA-Val-Cit-PAB-MMAE inhibits CYP3A4 activity (IC50 = 11.2 μM), induces intracellular ROS production and oxidative stress, disrupts the cytoskeleton through microtubule destabilization, and induces prostate cancer cell death. PSMA-Val-Cit-PAB-MMAE can be used in research related to prostate cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2748039-79-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-141860. | |
| PSN 375963 | PSN 375963 is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. PSN 375963 shows similar potency to the endogenous agonist oleoylethanolamide (OEA)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 388575-52-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108258. | |
| Psora-4 | Psora-4 is a potent and selective inhibitor of Kv1.3 (voltage-gated potassium channels) with an EC50 of 3 nM[1]. Psora-4 has immunosuppressive activity and inhibits proliferation of human and rat myelin-specific effector memory T cells in vitro[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5-(4-Phenylbutoxy)psoralen. CAS No. 724709-68-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108583. | |
| Psoralen | Psoralen (Ficusin) is a coumarin isolated from the seeds of Fructus Psoraleae. Psoralen exhibits a wide range of biological properties, including anti-cancer, antioxidant, antidepressant, anticancer, antibacterial, and antiviral, et al[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ficusin. CAS No. 66-97-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0053. | |
| Psoralidin | Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties[1]. Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 18642-23-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-N0232. | |
| Psoromic acid | Psoromic acid is a potent and selective RabGGTase (Rab geranylgeranyl transferase) inhibitor with an IC50 value of 1.3 μM. Psoromic acid is an antioxidative agent. Psoromic acid exhibits a competitive type of HMGR inhibition and mixed type of ACE (angiotensin converting enzyme) inhibition[1][2]. Uses: Scientific research. Category: Natural products. Alternative Names: Parellic acid. CAS No. 7299-11-8. Pack Sizes: 500 μg. Product ID: HY-130199. | |
| Psychosine | Psychosine (Galactosylsphingosine), a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease[1]. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell types including, most relevantly to globoid cell leukodystrophy (GLD), oligodendrocytes. Psychosine causes cell death at least in part via apoptosis. Psychosine also is an inhibitor of PKC[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Galactosylsphingosine. CAS No. 2238-90-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-136490. | |
| Psychosine-d5 | Psychosine-d5 is deuterium labeled Psychosine. Psychosine, a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Galactosylsphingosine-d5. CAS No. 2260670-12-8. Pack Sizes: 100 μg; 500 μg; 1 mg. Product ID: HY-136490S. | |
| p-Synephrine | p-Synephrine is an organic compound, found in multiple biofluids, such as urine and blood. Uses: Scientific research. Category: Signaling pathways. CAS No. 614-35-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg. Product ID: HY-113236. | |
| PT109 | PT109 is an orally active, blood-brain barrier permeable multi-kinase inhibitor. By inhibiting PTBP1, PT109 promotes the switch of pyruvate kinase isoform from PKM2 to PKM1, thereby effectively inhibiting the proliferation and migration of glioblastoma multiforme and inducing its reprogramming into oligodendrocytes. PT109 also targets and regulates key signaling molecules such as JNK, SGK1, GSK3β to exert neuroprotective effects including promoting neurogenesis, inducing synapse formation and alleviating neuroinflammation. In Alzheimer's disease models, PT109 exhibits significant efficacy in improving spatial learning ability, along with excellent in vivo pharmacokinetic properties. PT109 can be used to investigate metabolic reprogramming of glioblastoma multiforme and neuroprotective mechanisms of Alzheimer's disease[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2059104-90-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-167832. | |
| PT150 | PT150 (ORG-34517) is a competitive and orally active glucocorticoid receptor antagonist. PT150 shows neuroprotective effects. PT150 has the potential for the research of Parkinsons disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ORG-34517. CAS No. 189035-07-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-125558. | |
| PT-179 | PT-179 is an orthogonal Thalidomide (HY-14658) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein. For example, PT-179 binds to the ubiquitin ligase substrate receptor cereblon by forming a complex with SD40 and efficiently degrades proteins N- or C-terminally fused to SD40 or SD36 (DC50 for eGFP: 4.5 nM and 14.3 nM). PT-179 can be used to develop compact protein degradation tagging platforms[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2924858-25-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-160695. | |
| PT-2385 | PT-2385 is a selective HIF-2α inhibitor with a Ki of less than 50 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1672665-49-4. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12867. | |
| PT2399 | PT2399 is a potent and selective HIF-2α antagonist, which directly binds to HIF-2α PAS B domain with an IC50 of 6 nM. PT2399 displays potent antitumor activity in vivo[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1672662-14-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-108697. | |
| PT3 | PT3 is a selective inhibitor of HDAC3 with an IC50 value of 0.25 μM. PT3 exhibits good brain penetration ability and bioavailability upon oral administration. PT3 can be used in the research of Alzheimers disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2710273-81-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164782. | |
| PT-65 | PT-65 is a GSK3α and GSK3β PROTAC degrader with DC50 values of 28.3 nM and 34.2 nM, respectively. PT-65 inhibits excessive tau phosphorylation mediated by GSK3β, Aβ and Okadaic acid (HY-N6785). PT-65 is applicable for the research of Alzheimer's disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2721998-87-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153166. | |
| PT-91 | PT-91 is an agonist of GPR27. PT-91 exhibits high metabolic stability and brain exposure in mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3037561-48-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-163087. | |
| Pt(acac)2 | Pt(acac)2. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Platinum(II) acetylacetonate. CAS No. 15170-57-7. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-W034990. | |
| PTAD | PTAD (4-Phenyl-1,2,4-triazoline-3,5-dione) is a dieneophile reagent that can oxidize thiols into disulfides[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4-Phenyl-1,2,4-triazoline-3,5-dione. CAS No. 4233-33-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-W016748. | |
| PTC-209 | PTC-209 is a specific BMI-1 inhibitor with an IC50 of 0.5 μM in HEK293T cell line. PTC-209 irreversibly impairs colorectal cancer-initiating cells (CICs). PTC-209 shows potent anti-myeloma activity and impairs the tumor microenvironment[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 315704-66-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15888. | |
| PTC258 | PTC258 is a specific and orally active splicing modulator of Elongator complex protein 1 gene (ELP1). PTC258 increases the expression of ELP1 in vitro and in vivo. PTC258 is well tolerated in mouse model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2476724-74-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148772. | |
| PTC299 | PTC299 is an orally active inhibitor of VEGFA mRNA translation that selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydroorotate dehydrogenase (DHODH). PTC299 shows good oral bioavailability and lack of off-target kinase inhibition and myelosuppression. PTC299 can be useful for the research of hematologic malignancies[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Emvododstat. CAS No. 1256565-36-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124593. | |
| PTD10 | PTD10 is a selective and potent BTK PROTAC degrader (DC50 = 0.5 nM, KD = 2.28 nM). PTD10 can recruit cereblon (CRBN) E3 ligase and form a ternary complex with BTK, thereby mediating the ubiquitination and proteasome-dependent degradation of BTK. PTD10 inhibits cancer cells proliferation, and induces cell apoptosis via activation of the caspase-dependent pathway and mitochondrial pathway. PTD10 potently inhibits the BCR, AKT and NF-κB signaling pathway. PTD10 can be used for researches of B-cell malignancies and autoimmune disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2642231-19-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-154860. | |
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