MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| PTD-DBM | PTD-DBM is a CXXC5-Dvl protein-protein interaction inhibitor and also a Wnt/β-catenin pathway activator. PTD-DBM interferes with the Dvl-binding function of CXXC5, disrupts the negative feedback regulation of the Wnt/β-catenin pathway, induces β-catenin expression and nuclear translocation, and increases the production of type I collagen, α-smooth muscle actin and endothelin-1. PTD-DBM is applicable to studies related to androgenetic alopecia and skin wound healing[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1609454-11-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P11112. |  |
| Pteroic acid | Pteroic acid is a precursor to significant compounds like Folic acid (HY-16637) and Vitamin B12 (HY-B0315). Pteroic acid facilitates the examination of how different compounds influence cell growth and development[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 119-24-4. Pack Sizes: 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-79139. | |
| Pterosin B | Pterosin B is an orally active indanone. Pterosin B can be obtained from Pteridium aquilinum. Pterosin B is a Sik3 signaling inhibitor. Pterosin B inhibits Klf5 expression and reduces β-amyloid deposition. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice. Pterosin B inhibits cardiomyocyte hypertrophy, improves cognitive impairment, and lowers blood glucose. Pterosin B can be used in research on arthritis, Alzheimer's disease, pathological cardiac hypertrophy and diabetes[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 34175-96-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N1570. | |
| Pterostilbene | Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium[1]. Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties[1][4]. Pterostilbene blocks ROS production[3], also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide[4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 537-42-8. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-N0828. | |
| PTGR2-IN-1 | PTGR2-IN-1 is a potent PTGR2 inhibitor with an IC50 of ~0.7 μM. PTGR2-IN-1 increases 15-keto-PGE2-dependent PPARγ transcriptional activity in PTGR2-transfected HEK293T cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 349093-44-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122716. | |
| pTH (1-34) amide (human) | pTH (1-34) amide (human) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development[1]. Uses: Scientific research. Category: Peptides. CAS No. 83139-29-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4821. | |
| pTH (1-37) (human) | pTH (1-37) (human) is a fragment of parathyroid hormone (PTH). pTH (1-37) (human) induces the cAMP formation and increases alkaline phosphatase activity. pTH (1-37) (human) increases growth, bone calcium content, and bone mineral density (BMD) in uremic animals. pTH (1-37) (human) has the potential for the research of osteoporosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 136799-54-7. Pack Sizes: 100 μg; 500 μg; 1 mg; 5 mg. Product ID: HY-P4823. | |
| pTH (1-38) (human) | pTH (1-38) (human) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 78232-94-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4825. | |
| pTH-Related Protein (1-34) (human,mouse,rat) | pTH-Related Protein (1-34) (human, mouse, rat), a fragment of parathyroid hormone-related protein, is an anabolic agent. pTH-Related Protein (1-34) (human, mouse, rat) can be used for postmenopausal osteoporosis study[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: pTHrP (1-34). CAS No. 112540-82-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3075. | |
| PTP1B-IN-1 | PTP1B-IN-1 (Compound 7a) is a small molecule inhibitor of PTP1B with an IC50 value of 1.6 mM. It is often used as the mother core for derivatives of analogues[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PTP1B inhibitor. CAS No. 612530-44-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10704. | |
| PTP1B-IN-13 | PTP1B-IN-13 is a selective PTP1B inhibitor targeting the allosteric site with an IC50 value of 1.59 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 650621-20-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-139640. | |
| PTP1B-IN-2 | PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 50 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1919853-46-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100462. | |
| PTP1B-IN-3 | PTP1B-IN-3 is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP. PTP1B-IN-3 has antidiabetic and anticancer effects[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 809272-64-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-15133. | |
| PTP1B-IN-4 | PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 765317-72-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15756. | |
| PTPN2/1-IN-3 | PTPN2/1-IN-3 (compound 4) is a modified, orally active PTPN2/N1 inhibitor based on ABBV-CLS-484 (HY-145923). PTPN2/1-IN-3 has anti-tumor effects, inhibiting PTPN2 with an IC50 of 9.3 nM and having an oral bioavailability of 93% in mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3032920-59-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162428. | |
| PTPN22-IN-1 | PTPN22-IN-1 is a potent PTPN22 inhibitor (IC50=1.4 μM; Ki=0.50 μM). PTPN22-IN-1 exhibits >7-10 fold selectivity for PTPN22 over similar phosphatases. PTPN22-IN-1 augments antitumor immune responses[1]. From WO2021007491A1 compound L-1. Uses: Scientific research. Category: Signaling pathways. CAS No. 2580935-57-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139693. | |
| PTX80 | PTX80 is an antagonist of p62 with an IC50 value of 31.18 nM. PTX80 reduces tumor volume in an HCT116 colorectal cancer mouse xenograft model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2376297-69-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-169779. | |
| p-Tyramine-d4 hydrochloride | p-Tyramine-d4 (hydrochloride) is the deuterium labeled Tyramine hydrochloride. Tyramine hydrochloride is an amino acid that helps regulate blood pressure. Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1189884-47-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-W016823S. | |
| PU139 | PU139 is a potent pan-histone acetyltransferase (HAT) inhibitor. PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300 with IC50s of 8.39, 9.74, 2.49 and 5.35 μM, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 158093-65-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-124696. | |
| PU141 | PU141 is a selected pyridoisothiazolone HAT inhibitor. PU141 is selective toward CBP and p300. PU141 induces cellular histone hypoacetylation and inhibits growth of several neoplastic cell lines originating from different tissues. Anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 168334-34-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120290. | |
| PU.1-IN-1 | PU.1-IN-1 is a potent PU.1 inhibitor with an IC50 of 2 nM. PU.1-IN-1 reduces rMANF-induced miR-223 expression. PU.1-IN-1 exhibits anti-inflammatory properties[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 873588-27-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W176171. | |
| PU 23 | PU 23 is a non-carboxylic multidrug resistance protein 4 (MRP4) inhibitor as an active agent reducing resistance to anticancer agent 6-Mercaptopurine[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 817635-93-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136217. | |
| Puerarin | Puerarin is an isoflavone extracted from Pueraria root and is a 5-HT2C receptor antagonist. Puerarin inhibits the dorsal motor nucleus of the vagus (DMV)-vagus nerve pathway, which in turn leads to decreased fat absorption[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3681-99-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0145. | |
| PU-H54 | PU-H54, a Grp94-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy[1]. PU-H54 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1454619-13-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-117395. | |
| Pulcherriminic acid | Pulcherriminic acid is a cyclic dipeptide antimicrobial agent with high affinity for Fe3+, found mainly in Bacillus and yeast. Pulcherriminic acid chelates iron ions through a non-enzymatic reaction to form the extracellular red pigment pulcherrimin, which competes for iron nutrition and thus achieves an antibacterial effect. Pulcherriminic acid has great applications in food, agriculture and medical industries[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 957-86-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N10473. | |
| Pulchinenoside C | Pulchinenoside C (Anemoside B4) is Pulsatilla koreana Nakai that have many numerous biological effects in vitro, including enhancing hypoglycemic, anti-tumor, neuroprotective and anti-angiogenic activity. Uses: Scientific research. Category: Natural products. Alternative Names: Anemoside B4. CAS No. 129741-57-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0205. | |
| Pullulanase | Pullulanase (R-enzyme) is a key starch debranching enzyme that specifically hydrolyzes α-1,6-glycosidic linkages in polysaccharides such as amylopectin and pullulan, facilitating the efficient degradation of starch into fermentable sugars[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R-enzyme. CAS No. 9075-68-7. Pack Sizes: 1 g; 5 g; 10 g. Product ID: HY-P3173. | |
| Pullulan, Viscosity(10%):15-180mPa.s | Pullulan (Pullulan standard 5800) (Mw 362-480 kDa; Mn 100-200 kDa) is a class of orally active and water-soluble linear glucosic polysaccharide. Pullulan can be isolated from the polymorphic fungus Aureobasidium pullulans. Pullulan is composed of maltotriose repeating units linked by α-1,6 linkages and is an amorphous slime matter. Pullulan is widely used in food, environment, pharmaceutical, manufacturing, and electronics[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9057-2-7. Pack Sizes: 10 g; 25 g. Product ID: HY-W145522. | |
| Pulrodemstat | Pulrodemstat (CC-90011) is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 of 0.25 nM. Pulrodemstat is less enzymatic inhibition against LSD2, MAO-A, and MAO-B. Pulrodemstat induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CC-90011; LSD1-IN-7. CAS No. 1821307-10-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129388A. | |
| Pulrodemstat benzenesulfonate | Pulrodemstat (CC-90011) benzenesulfonate is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 of 0.25 nM. Pulrodemstat benzenesulfonate is less enzymatic inhibition against LSD2, MAO-A, and MAO-B. Pulrodemstat benzenesulfonate induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CC-90011 benzenesulfonate; LSD1-IN-7 benzenesulfonate. CAS No. 2097523-60-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-129388B. | |
| Pulsatilla saponin D | Pulsatilla saponin D (SB365), isolated from the root of Pulsatilla chinensis, is an anti-tumor agent[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SB365; Hederacolchiside A. CAS No. 68027-15-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-N0834. | |
| Punicalagin | Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 65995-63-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 20 mg; 50 mg; 100 mg. Product ID: HY-N0063. | |
| Punicalagin (Standard) | Punicalagin (Standard) is the analytical standard of Punicalagin. This product is intended for research and analytical applications. Punicalagin is a polyphenol ingredient isolated from Pomegranate (Punica granatum L.) or the leaves of Terminalia catappa L. Punicalagin is a reversible and non-competitive 3CLpro inhibitor and inhibits SARS-CoV-2 replication in vitro. Punicalagin is an anti-hepatitis B virus (HBV) agent and has antioxidant, anti-inflammatory, and anticancer effects. Punicalagin has the potential for the research of COVID-19[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 65995-63-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0063R. | |
| Punicalin | Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a Carbonic anhydrase inhibitor. Punicalin blocks the binding of S-glycoprotein and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity[1][2][3][4][5][6][7]. Uses: Scientific research. Category: Signaling pathways. CAS No. 65995-64-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N0639. | |
| Purine | Purine is an endogenous metabolite. Purine bases are the building blocks of the nucleic acids. Purine inhibits the activation of PARP. Purine protects against oxidant-induced cell injury. Purine can be used in the research of cancer and nervous system diseases[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 7H-Imidazo(4,5-d)pyrimidine. CAS No. 120-73-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-34431. | |
| Purinostat | Purinostat is a selective inhibitor of HDAC I/IIb with anti-leukemic activity. Purinostat mesylate (HY-150109), the mesylate salt of Purinostat, inhibits the survival of Ph+ leukemic cells and CD34+ leukemic cells derived from CML patients. Purinostat mesylate targets HDAC I/IIb to inhibit several important factors for leukemic stem cell (LSC) survival, including c-Myc, β-Catenin, E2f, Ezh2, Alox5, and mTOR. Purinostat mesylate increases glutamate metabolism in LSC by increasing GLS1[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1929583-17-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150109A. | |
| Purinostat mesylate | Purinostat mesylate is a selective inhibitor of HDAC. Purinostat mesylate inhibits class I and class IIb HDACs with IC50s from 0.81 to 11.5 nM. Purinostat mesylate induces apoptosis and affects cell cycle of LAMA84 and 188 BL-2 cells, and shows potently anti-leukemia effects in vivo. Purinostat mesylate can be used for the research of lymphoblastic leukemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2650188-32-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150109. | |
| Purmorphamine | Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 483367-10-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-15108. | |
| Purmorphamine (GMP) | Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 483367-10-8. Pack Sizes: 10 mg; 50 mg; 100 mg. Product ID: HY-15108G. | |
| Puromycin | Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CL13900. CAS No. 53-79-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1743. | |
| Puromycin aminonucleoside | Puromycin aminonucleoside (NSC 3056) is the aminonucleoside portion of the antibiotic puromycin, and used in nephrosis animal models[1]. Puromycin aminonucleoside induces apoptosis[2]. Puromycin aminonucleoside is a reversible inhibitor of dipeptidyl peptidase II and cytosol alanyl aminopeptidase[3]. Puromycin aminonucleoside induces secretion of cell migrasome[4]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: NSC 3056. CAS No. 58-60-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-15695. | |
| Puromycin-bis(PEG2-amide)-Biotin | Puromycin-bis (PEG2-amide)-Biotin (Compound 3P) is a binding molecule. Puromycin-bis (PEG2-amide)-Biotin binds to ribosome-RNA complexes within single cells. Puromycin-bis (PEG2-amide)-Biotin is used for single-cell translatome sequencing[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2379889-82-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-148865. | |
| Puromycin dihydrochloride | Puromycin dihydrochloride (CL13900 dihydrochloride), an aminonucleoside antibiotic, inhibits protein synthesis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CL13900 dihydrochloride. CAS No. 58-58-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-B1743A. | |
| Puromycin (Standard) | Puromycin (Standard) is the analytical standard of Puromycin. This product is intended for research and analytical applications. Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CL13900 (Standard). CAS No. 53-79-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1743R. | |
| Purvalanol A | Purvalanol A is a potent CDK inhibitor, which inhibits cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, cdk4-cyclin D1, and cdk5-p35 with IC50s of 4, 70, 35, 850, 75 nM, resepctively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NG-60. CAS No. 212844-53-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18299A. | |
| Purvalanol B | Purvalanol B (NG 95) is a potent, selective, reversible and ATP-competitive inhibitor CDK, with IC50s of 6 nM, 6 nM, 9 nM, 6 nM for cdc2-cyclin B, CDK2-cyclin A, CDK2-cyclin E and CDK5-p35, respectively. Purvalanol B shows selectivity for CDK over a range of other protein kinases (IC50>1000 nM). Purvalanol B inhibits the growth a chloroquine-resistant strain of P. falciparum[1][1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NG 95. CAS No. 212844-54-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-18299. | |
| PU-WS13 | PU-WS13 is a selective Grp94 inhibitor, with an EC50 of 0.22 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1454619-14-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18680. | |
| Puxitatug | Puxitatug (INT-016; AZD8205 Antibody) is a monoclonal antibody targeting VTCN1/B7-H4. Puxitatug can be used to synthesize antibody-drug conjugates (ADCs), such as Puxitatug samrotecan (HY-171689), which can be applied to various solid tumors. Puxitatug can also be used for researching adjuvant therapies for gastric cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: INT-016; AZD8205 Antibody. CAS No. 2760250-47-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990059. | |
| Puxitatug samrotecan | Puxitatug samrotecan (AZD 8205) is a B7-H4-directed antibody-drug conjugate (ADC) bearing a Topoisomerase I inhibitor (TOP1i) payload. Puxitatug samrotecan improves HR+/HER2- breast cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD 8205; P-Sam. CAS No. 2760250-80-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-171689. | |
| PVD-06 | PVD-06 is a selective PROTAC PTPN2 degrader with a DC50 of 217 nM (selectivity index >60-fold over PTP1B). PVD-06 induces PTPN2 degradation via a VHL-, ubiquitin, and proteasome-dependent pathway. PVD-06 can promote T cell activation and amplify IFN-γ-mediated anticancer activity. PVD-06 can be used to further investigate PTPN2 in diseases such as leukemia and melanoma[1]. (Pink: PTPN2 ligand (HY-168691), Black: linker (HY-B0236), Blue: VHL ligand (HY-112078)). Uses: Scientific research. Category: Signaling pathways. CAS No. 3032975-48-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-149760. | |
| PW0729 | PW0729 is a selective GPR52 agonist. PW0729 activates G protein/cAMP signaling pathway, with bias toward this pathway over β-arrestin recruitment, and induces GPR52 desensitization. PW0729 can be used for the research of neuropsychiatric and neurological diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2767348-36-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-163671. | |
| PW0787 | PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM). PW0787 suppresses psychostimulant behavior[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2624131-45-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138639. | |
| PX-12 | PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1 (Trx-1); inhibits the growth of MCF-7 and HT-29 cells with IC50 values of 1.9 and 2.9 μM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IV-2. CAS No. 141400-58-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13734. | |
| PX-478 | PX-478 is an orally active HIF-1α inhibitor with potent antitumor activities. PX-478 can cross the blood-brain barrier[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 685898-44-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10231. | |
| PXL770 | PXL770 is an orally active, direct allosteric AMP-activated protein kinase (AMPK) activator. PXL770 decreases C26:0 levels, improves mitochondrial respiration, reduces expression of proinflammatory genes and induces expression of compensatory transporters (ABCD2/3) in ALD fibroblasts/lymphocytes. PXL770 normalizes plasma VLCFA levels, significantly reduces elevated VLCFA levels in brain and spinal cord in Abcd1 KO mice. PXL770 improves glycemia, dyslipidemia, and insulin resistance in ob/ob and high-fat diet (HFD)-fed mice. PXL770 can be used for the study of X-linked adrenoleukodystrophy (ALD), autosomal dominant polycystic kidney disease and nonalcoholic steatohepatitis (NASH)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1523493-53-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160004. | |
| PXS-4787 hydrochloride | PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor for abolishing lysyl oxidase activity. PXS-4787 hydrochloride inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4), respectively. PXS-4787 hydrochloride reduces deposition and crosslinking of collagen I secreted by human fibroblasts[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2409964-40-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151498A. | |
| PXS-5505 anhydrous | PXS-5505 anhydrous (LOX-IN-3 dihydrochloride) is an orally active lysyl oxidase (LOX) inhibitor. PXS-5505 anhydrous can be used for fibrosis, cancer and angiogenesis research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LOX-IN-3 dihydrochloride. CAS No. 2409964-23-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138625A. | |
| PXS-5505 free base | PXS-5505 free base (LOX-IN-3) is an orally active lysyl oxidase (LOX) inhibitor. PXS-5505 free base can be used for fibrosis, cancer and angiogenesis research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LOX-IN-3. CAS No. 2409963-83-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138625. | |
| PXS-6302 hydrochloride | PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor with IC50s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 hydrochloride has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2584947-79-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151499A. | |
| PXYC1 | PXYC1 is a ribosomal protein S1 (RpsA) antagonist with Kds of 0.81 and 0.31 μM for RpsA-CTD and RpsA-CTD Δ438A, respectively. RpsA plays an important role in the trans-translation process of Mycobacterium Tuberculosis (Mtb)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 865098-81-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146446. | |
| PY-60 | PY-60 is a robust and specific activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a Kd of 1.4 μM. PY-60 directly binds to ANXA2 and antagonizes its normal cellular function of repressing YAP activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2765218-56-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141644. | |
| Py-BODIPY-NHS ester | BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions[1]. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the neutral lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 201998-61-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1106. | |
| PYCR1-IN-1 | PYCR1-IN-1 (compound 4) is a pyrroline-5-carboxylate reductase 1 (PYCR1) inhibitor with an IC50 of 8.8 μM. PYCR1-IN-1 has anticancer effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 709-85-3. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126271. | |
| pYEEI | pYEEI is a phosphotyrosine-containing tetrapeptide binds to Src SH2 domain with the Kd of 100 nM and with the IC50 of 6.5 μM. pYEEI plays an important role in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 198472-14-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P10665. | |
| Pyk2-IN-2 | Pyk2-IN-2 (compound 13j) is an inhibitor of Pyk2 with an IC50 of FAK kinase of 0.608 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1271418-15-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-401485. | |
| Py-MAA-Val-Cit-PAB-MMAE | Py-MAA-Val-Cit-PAB-MMAE is a drug-Linker conjugates for ADC, which is composed of MMAE (HY-15162) and Py-MAA-Val-Cit-PAB linked. Py-MAA-Val-Cit-PAB-MMAE can be used to synthesize Zapadcine-3a, which targeting TRAILR2. Zapadcine-3a has broad-spectrum anti-tumor activity, and can specifically kill TRAILR2-positive tumors[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2247398-68-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148875. | |
| Pyocyanin | Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pyocyanine; Sanazin; Sanasin. CAS No. 85-66-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111278. | |
| PYR01 | PYR01 is a non-nucleoside reverse transcriptase inhibitor and a killing activator targeting HIV infected cells. PYR01 has cytokilling and antiviral properties of HIV-1 infection with the IC50 values of 27.5nM and 39.7nM, respectively. PYR01 leads to selective cytotoxicity by promoting HIV-1 Gag-Pol dimerization and HIV-1 protease intracellular activation. PYR01 can be used in the study of HIV[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2560576-15-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153225. | |
| [Pyr1]-Apelin-13 | [Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist. Uses: Scientific research. Category: Signaling pathways. Alternative Names: [pGlu1]-Apelin-13. CAS No. 217082-60-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1033. | |
| Pyr3 | Pyr3 is a selective inhibitor of transient receptor potential canonical channel 3 (TRPC3), with an IC50 of 700 nM for TRPC3-mediated Ca2+ influx. Uses: Scientific research. Category: Signaling pathways. CAS No. 1160514-60-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108465. | |
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