MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| PZ-2891 | PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2170608-82-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124634. |  |
| PZ703b | PZ703b is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b can be used for the research of bladder cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2471970-56-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-115718. | |
| PZL-A | PZL-A is a activator of mitochondrial DNA (mtDNA) synthesis. PZL-A restores wild-type-like activity to mutant forms of polymerase γ (POLγ) with AC50 s of 160 and 20 nM for A467T and G848S. PZL-A activates mtDNA synthesis in cells, enhancing biogenesis of the oxidative phosphorylation machinery and cellular respiration. PZL-A is promising for relieving POLG disease and other severe conditions linked to depletion of mtDNA[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3068830-89-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-174216. | |
| PZM21 | PZM21 is a potent and selective μ opioid receptor agonist with an EC50 of 1.8 nM[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1997387-43-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101386. | |
| QC-01-175 | QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 (HY-W453397); Black: linker NH2-PEG3 (HY-W007545); Blue: ligand for E3 ligase Pomalidomide (HY-10984))[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2267290-96-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134850. | |
| QC6352 | QC6352 is an orally active KDM4 inhibitor with anti-tumor and anti-proliferative activity. QC6352 has in vivo inhibitory effects on PDX models of breast and colon cancer and reduces the number of chemoresistant cell populations. QC6352 inhibits KDM4 different isoforms with IC50s of 104 nM (KDM4A), 56 nM (KDM4B), 35 nM (KDM4C), and 104 nM (KDM4D), respectively. QC6352 has moderate inhibitory activity against KDM5 with an IC50 of 750 nM (KDM5B)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1851373-36-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104048. | |
| QCA570 | QCA570 is a PROTAC connected by ligands for Cereblon and BET, with an IC50 of 10 nM for BRD4 BD1 Protein. Uses: Scientific research. Category: Signaling pathways. CAS No. 2207569-08-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112609. | |
| Qingdainone | Qingdainone is a natural product that can be obtained from Qingdai. Qingdainone has the potential to study cancer and inflammation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 97457-31-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W749874. | |
| QL-1200186 | QL-1200186 is a selective, orally active, allosteric inhibitor targeting the tyrosine kinase TYK2 pseudokinase domain JH2 (IC50=0.06 nM, TYK2 JH2), with 164-fold selectivity over TYK1 JH2 (IC50=9.85 nM, TYK1 JH2). QL-1200186 first stabilizes the TYK2 JH2 conformation, inhibits the activity of the JH1 catalytic domain, and blocks the IFNα, IL-12/IL-23-mediated JAK-STAT signaling pathway. QL-1200186 can inhibit the production of Th1/Th17 cell-related cytokines (such as IFNγ, IL-23), reduce immune cell activation, and has no significant effect on JAK1/2/3 kinase activity. QL-1200186 can significantly improve skin inflammation in the Imiquimod (HY-B0180)-induced psoriasis mouse model and reduce the Psoriasis Area and Severity Index (PASI) score. QL-1200186 can be used in the study of autoimmune diseases such as psoriasis and systemic lupus erythematosus (SLE)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2848664-42-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-156466. | |
| QM295 | QM295 is an endoplasmic reticulum oxidation 1 (ERO1) inhibitor with selectively reversible thiol reactivity. QM295 can be used for the research of endoplasmic reticulum stress[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1241046-32-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148520. | |
| QM385 | QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC50 of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2093421-02-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114388. | |
| QNZ | QNZ (EVP4593) shows strong inhibitory effects on NF-κB transcriptional activation and TNF-α production with IC50s of 11 and 7 nM, respectively. QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EVP4593. CAS No. 545380-34-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13812. | |
| QO 58 | QO 58 is a potent modulator of K(V)7 channels. QO-58 increases the current amplitudes, shifts the voltage-dependent activation curve in a more negative direction and slows the deactivation of K(V)7.2/K(V)7.3 currents. QO-58 has the potential for the research of diseases associated with neuronal hyperexcitability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1259536-62-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110162. | |
| QP5 | QP5 is an Amelogenin (HY-P71627)-derived peptide. QP5 binds to hydroxyapatite and demineralized enamel surfaces, temporarily stabilizes amorphous calcium phosphate (ACP), and regulates the crystallization of hydroxyapatite. QP5 promotes remineralization of artificial enamel caries in vitro, and acts synergistically with fluoride to enhance enamel caries remineralization. QP5 can be used in studies related to enamel caries and early enamel caries[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1501983-51-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P11111. | |
| QP5038 | QP5038 (compound 28) is an inhibitor of QPCTL with an IC50 value of 3.8?nM. QP5038 has antitumor efficacy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3031429-88-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-161078. | |
| QS11 | QS11 is an inhibitor of ARFGAP1 (ADP-ribosylation factor GTPase-activating protein 1), with an EC50 of 1.5 μM. QS11 activates Wnt/β-catenin signaling through an effect on protein trafficking. QS11 inhibits migration of ARFGAP overexpressing breast cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 944328-88-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12762. | |
| QS-21-Api | QS-21-Api, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21-Api stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21-Api can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Stimulon. CAS No. 141256-04-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-101092. | |
| QS-21-Xyl | QS-21-Xyl is a active component of QS-21 (HY-101092A). QS-21 is a natural vaccine adjuvant and induces a balanced Th1/Th2 immune response, particularly cellular immunity[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 250643-56-2. Pack Sizes: 1 mg. Product ID: HY-101092B. | |
| QTX125 TFA | QTX125 TFA is a potent and highly selective HDAC6 inhibitor. QTX125 TFA exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2989537-78-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120448A. | |
| QTZ | QTZ is a bioluminescence agent for in vivo imaging. QTZ has red-shifted emission and yields very little background. QTZ is a coelenterazine analog with the 4-quinolinyl substitution at the C8 position of the imidazopyrazinone core[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2883232-39-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-47176. | |
| Quabodepistat | Quabodepistat (OPC-167832) is a potent and orally active dprE1 inhibitor with an IC50 of 0.258 μM. Quabodepistat has antituberculosis activity and can be used for the research of tuberculosis caused by Mycobacterium tuberculosis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: OPC-167832. CAS No. 1883747-71-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134940. | |
| Quarfloxin | Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CX-3543. CAS No. 865311-47-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14776. | |
| Quercetagetin | Quercetagetin (6-Hydroxyquercetin) is a flavonoid[1]. Quercetagetin is a moderately potent and selective, cell-permeable pim-1 kinase inhibitor (IC50, 0.34 μM)[2]. Anti-inflammatory and anticancer properties. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 6-Hydroxyquercetin. CAS No. 90-18-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N4149. | |
| Quercetagitrin | Quercetagitrin (Quercetagetin-7-O-glucoside) is a natural product that can be isolated from the African marigold (Tagetes erecta). Quercetagitrin has anti-inflammatory activity. Quercetagitrin inhibits Tau accumulation. Quercetagitrin can reverse neuroinflammation and cognitive deficits in P301S-Tau transgenic mouse model through inhibiting NF-κB activation. Quercetagitrin is a dual-target inhibitor of PTPN6 (IC50 = 1 μM) and PTPN9 (IC50 = 1.7 μM). Quercetagitrin enhances glucose uptake by mature C2C12 myoblasts. Quercetagitrin can be studied in research for Alzheimers disease and type 2 diabetes[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Quercetagetin-7-O-glucoside. CAS No. 548-75-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N4150. | |
| Quercetin | Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 117-39-5. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-18085. | |
| Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside | Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside is from the fresh leaves of Psidium Guajava L.[1]. Uses: Scientific research. Category: Natural products. CAS No. 53171-28-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N7024. | |
| Quercetin 3-O-β-D-glucofuranoside | Quercetin 3-O-β-D-glucofuranoside is an effective antioxidant and an eosinophilic inflammation suppressor. Uses: Scientific research. Category: Signaling pathways. CAS No. 21637-25-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0768. | |
| Quercetin-3'-O-glucoside | Quercetin-3'-O-glucoside is an orally active flavonoid glycoside. Quercetin-3'-O-glucoside reduces liver glucose-6-phosphatase activity, alters serum insulin and glucose levels, and regulates the activities of antioxidant enzymes in the liver and kidney. Quercetin-3'-O-glucoside inhibits DNA topoisomerase II, induces S-phase cell cycle arrest and caspase-3-mediated apoptosis in hepatocellular carcinoma cells. Quercetin-3'-O-glucoside selectively inhibits EGFR-mediated signaling pathways targeting AKT, ERK1/2, FAK and MEK1/2. Quercetin-3'-O-glucoside inhibits growth factor-induced migration and invasion in pancreatic cancer cells. Quercetin-3'-O-glucoside exerts free radical scavenging effects. Quercetin-3'-O-glucoside is applicable to research related to pancreatic cancer, diabetes, hepatocellular carcinoma and malignant tumors[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 19254-30-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N12445. | |
| Quercetin 3-O-glucoside-7-O-rhamnoside | Quercetin 3-O-glucoside-7-O-rhamnoside is a member of flavonoid glycosides group with an inhibitory activity on the CNS[1]. Uses: Scientific research. Category: Natural products. CAS No. 18016-58-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N5075. | |
| Quercetin 3-O-rutinoside-7-O-glucoside | Quercetin 3-O-rutinoside-7-O-glucoside is a flavonol glycoside and a derivative of Quercetin (HY-18085). Quercetin 3-O-rutinoside-7-O-glucoside can be isolated from the leaves and fruits of Korean Morus alba L. as well as the leaves of Hemerocallis fulva. Quercetin 3-O-rutinoside-7-O-glucoside inhibits lipid peroxidation in large unilamellar vesicles in vitro. Quercetin 3-O-rutinoside-7-O-glucoside possesses antioxidant activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 30311-61-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N10407. | |
| Quercetin 7-glucuronide | Quercetin 7-glucuronide (Quercetin 7-O-β-glucuronide), a metabolite of Quercetin (HY-18085), can be isolated from Madagascarian Uncarina species. Quercetin 7-glucuronide can inhibit LDL oxidation[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Quercetin 7-O-β-glucuronide. CAS No. 38934-20-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W778608. | |
| Quercetin-d3 | Quercetin-d3 is the deuterium labeled Quercetin. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 263711-79-1. Pack Sizes: 2.5 mg. Product ID: HY-18085S1. | |
| Quercetin (GMP) | Quercetin GMP is Quercetin (HY-18085) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Quercetin is a flavonoid antioxidant, a PI3K inhibitor and a SIRT1 Activator[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 117-39-5. Pack Sizes: 10 mg; 50 mg; 100 mg. Product ID: HY-18085G. | |
| Quercetin hydrate | Quercetin hydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 849061-97-8. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-18085A. | |
| Quercetin (Standard) | Quercetin (Standard) is the analytical standard of Quercetin. This product is intended for research and analytical applications. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 117-39-5. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18085R. | |
| Quercitrin | Quercitrin (Quercetin 3-rhamnoside) is a bioflavonoid compound with potential anti-inflammation, antioxidative and neuroprotective effect. Quercitrin induces apoptosis of colon cancer cells. Quercitrin can be used for the research of cardiovascular and neurological disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Quercetin 3-rhamnoside. CAS No. 522-12-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0418. | |
| Quetiapine | Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ICI204636. CAS No. 111974-69-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14544. | |
| Quetiapine-d4 hemifumarate | Quetiapine-d4 (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1217310-65-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-B0031S1. | |
| Quetiapine hemifumarate | Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 111974-72-2. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0031. | |
| Quetmolimab | Quetmolimab (E6011) is a humanized anti-Fractalkine (CX3CL1) monoclonal antibody. Quetmolimab binds to membrane-bound and soluble Fractalkine, neutralizes Fractalkine-induced migration of CX3CR1-expressing cells, mediates target-bound complex elimination from serum. Quetmolimab suppresses free soluble Fractalkine levels in cynomolgus monkeys, with target engagement linked to increased serum total Fractalkine concentration. Quetmolimab can be used for the research of Crohns disease, rheumatoid arthritis, and primary biliary cholangitis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: E6011. CAS No. 2084037-83-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99404. | |
| Queuine | Queuine is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 72496-59-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N10574. | |
| Quiflapon | Quiflapon (MK-591) is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50 of 1.6 nM in a FLAP binding assay. Quiflapon is also a potent and orally active Leukotriene biosynthesis (LT) inhibitor, shows IC50 values of 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively. Quiflapon induces cell apoptosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK-591. CAS No. 136668-42-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10037. | |
| Quilizumab | Quilizumab (Anti-Human IGHE Recombinant Antibody) is a humanized IgG1κ monoclonal antibody targeting immunoglobulin epsilon (also konwn as: IGHE, IgE). Quilizumab targets the M1-prime fragment of membrane-expressed IGHE/IgE, leading to IGHE/IgE switching and memory B cell depletion. Quilizumab has potential in asthma research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Anti-Human IGHE Recombinant Antibody. CAS No. 1228538-47-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99313. | |
| Quillaic acid | Quillaic acid (Quillaja sapogenin)It is an anti-gastric cancer and anti-proliferation agent that can promote apoptosis of cancer cells. (apoptosis). Quillaic acidAlso has analgesic and local anti-inflammatory activity[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Quillaja sapogenin. CAS No. 631-01-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0839. | |
| Quinacrine | Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC50: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm)[1][2][3][4][7]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Acriquine. CAS No. 83-89-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13735. | |
| Quinacrine mustard dihydrochloride | Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4213-45-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-W127705. | |
| Quinagolide hydrochloride | Quinagolide hydrochloride (CV205-502 hydrochloride) is a selective and orally active dopamine D2 receptor agonist. Quinagolide hydrochloride is an inhibitor of prolactin. Quinagolide hydrochloride down-regulates AKT levels and its phosphorylation. Quinagolide hydrochloride shows antitumor effects, it can be used for the research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CV205-502 hydrochloride. CAS No. 94424-50-7. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13736A. | |
| Quinaprilat | Quinaprilat is an orally active non-mercapto Angiotensin Converting Enzyme (ACE) inhibitor, the active metabolite of Quinapril. Quinaprilat specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits the degradation of bradykinin. Quinaprilat acts as anti-hypertensive agent and vasodilator[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 82768-85-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-127026. | |
| Quinapril hydrochloride | Quinapril (hydrochloride) (CI-906) is a proagent that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CI-906. CAS No. 82586-55-8. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0477. | |
| Quin-C7 | Quin-C7 is an orally active FPR2/ALX antagonist. Quin-C7 has anti-inflammatory activity and can ameliorate DSS (HY-116282)-induced colitis in mice. Quin-C7 can be used in the research of inflammatory bowel disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 871100-12-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W668775. | |
| Quinidine (15% dihydroquinidine) | Quinidine (15% dihydroquinidine) is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine can be used for malaria research[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 56-54-2. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-B1751. | |
| Quinidine hydrochloride monohydrate | Quinidine hydrochloride monohydrate is an orally active antiarrhythmic agent. Quinidine hydrochloride monohydrate reduces the expression level of P-gp, inhibits P-gp-mediated efflux, increases the intracellular accumulation of P-gp substrates, induces PARP cleavage and Caspase-3 activation, and elevates the proportion of Apoptotic cells at the sub-G1 phase. Quinidine hydrochloride monohydrate exerts sustained block and open-channel block effects on IK(f). Quinidine hydrochloride monohydrate alters the urinary metabolic ratio of Amphetamine, modulates the Pentylenetetrazol-induced seizure threshold, and regulates the anticonvulsant effect of Dextromethorphan. Quinidine hydrochloride monohydrate can be used in studies related to uterine sarcoma and seizures[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6151-40-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B1302. | |
| Quinidine methiodide | Quinidine methiodide is a metabolite of Quinidine. Quinidine is an antiarrhythmic agent[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 42982-87-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150123. | |
| Quin II potassium | QUIN 2, Tetrapotassium Salt is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. CAS No. 73630-23-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-135269. | |
| Quinine | Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 130-95-0. Pack Sizes: 500 mg; 1 g; 5 g; 10 g; 25 g. Product ID: HY-D0143. | |
| Quinine sulfate | Quinidine sulfate is an antiarrhythmic agent. Quinidine sulfate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate is also a K+ channel blocker with an IC50 of 19.9 μM. Quinidine sulfate can be used for malaria research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 549-56-4. Pack Sizes: 50 mg; 100 mg. Product ID: HY-B1751B. | |
| Quinolinic acid | Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis[1][2][3][4][5][6][7][8]. Uses: Scientific research. Category: Induced disease models products. CAS No. 89-00-9. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 10 g; 50 g; 100 g. Product ID: HY-100807. | |
| Quinolinic acid-d3 | Quinolinic acid-d3 is the deuterium labeled Quinolinic acid. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis. Uses: Scientific research. Category: Signaling pathways. CAS No. 138946-42-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-100807S. | |
| Quinolinic acid (Standard) | Quinolinic acid (Standard) is the analytical standard of Quinolinic acid. This product is intended for research and analytical applications. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis. Uses: Scientific research. Category: Signaling pathways. CAS No. 89-00-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100807R. | |
| Quinpirole hydrochloride | Quinpirole hydrochloride (LY 171555 hydrochloride) is a high-affinity agonist of dopamine D2/D3 receptor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY 171555 hydrochloride; (-)-LY 141865 hydrochloride. CAS No. 85798-08-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1752A. | |
| Quinupristin | Quinupristin is a streptogramin antibiotic. Quinupristin blocks peptide bond synthesis to prevent the extension of polypeptide chains and promote the detachment of incomplete protein chains in the bacterial ribosomal subunits[1] [2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 120138-50-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-A0162. | |
| Quisinostat | Quisinostat (JNJ-26481585) is a potent and orally active pan-HDAC inhibitor (HDACi), with IC50 values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11. Quisinostat has a broad spectrum antitumoral activity[1]. Quisinostat can induce autophagy in neuroblastoma cells[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ-26481585. CAS No. 875320-29-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15433. | |
| Quisinostat dihydrochloride | Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally active, potent pan-HDAC inhibitor with IC50s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity. Quisinostat dihydrochloride can induce autophagy in neuroblastoma cells[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ-26481585 dihydrochloride. CAS No. 875320-31-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15433A. | |
| Quisovalimab | Quisovalimab (AVTX-002) is a human-derived monoclonal antibody against LIGHT (TNFSF14). Quisovalimab binds to LIGHT, blocks the signal transduction activity of LIGHT, reduces circulating LIGHT levels and attenuates pro-inflammatory effects. Quisovalimab can be used in research related to Crohn's disease, COVID-19-associated pneumonia and acute respiratory distress syndrome comorbidity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AVTX-002; AEVI 002; SAR 252067; CERC-002; MDGN-002. CAS No. 2427667-03-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99810. | |
| Quisqualic acid | Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: L-Quisqualic acid. CAS No. 52809-07-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-12597. | |
| Quizalofop-p-ethyl | Quizalofop-P-ethyl is a low-toxicity herbicide, a highly selective new type of post-emergence herbicide for dryland crops, with high selectivity between gramineous weeds and dicotyledonous crops, and it has good control efficacy against gramineous weeds in broadleaf crop fields. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-Quizalofop ethyl; Quinofop-ethyl. CAS No. 100646-51-3. Pack Sizes: 10 mM * 1 mL in DMSO; 200 mg. Product ID: HY-B1950. | |
| Quizartinib | Quizartinib (AC220) is an orally active, potent and selective FLT3 inhibitor. Quizartinib inhibits kinase activity of mutant-FLT3, -PDGFRA and -KIT isoforms and inhibits autophosphorylation. Quizartinib inhibits cellular proliferation, induces apoptosis in cancer cells. Quizartinib can be used for the research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AC220. CAS No. 950769-58-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-13001. | |
| Quizartinib dihydrochloride | Quizartinib (AC220) dihydrochloride is an orally active, potent and selective FLT3 inhibitor. Quizartinib dihydrochloride inhibits kinase activity of mutant-FLT3, -PDGFRA and -KIT isoforms and inhibits autophosphorylation. Quizartinib dihydrochloride inhibits cellular proliferation, induces apoptosis in cancer cells. Quizartinib dihydrochloride can be used for the research of cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AC220 dihydrochloride. CAS No. 1132827-21-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14217. | |
| Q-VD-OPh | Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with an IC50 of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPh can inhibits HIV infection. Q-VD-OPh is able to cross the blood-brain barrier. Uses: Scientific research. Category: Signaling pathways. Alternative Names: QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone. CAS No. 1135695-98-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12305. | |
| QWF Peptide | QWF Peptide (Compound 4a) is a substance P antagonist with an IC50 of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC50 of 4.7 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 126088-82-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-135108. | |
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