MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| BAY 60-2770 | BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1027642-43-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113926. |  |
| BAY-6035 | BAY-6035, a chemical probe, is a potent, selective and substrate-competitive inhibitor of SMYD3. BAY-6035 inhibits methylation of MEKK2 peptide with an IC50 of 88 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2247890-13-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-112080. | |
| BAY 60-6583 | BAY 60-6583 is a potent and high-affinity agonist of adenosine A2B receptor (EC50=3 nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with Ki values of 750 nM, 340 nM and 330 nM, respectively. BAY 60-6583 has a cardioprotective effect in a myocardial ischemia model[1][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 910487-58-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103171. | |
| Bay 60-7550 | Bay 60-7550 is a potent and selective PDE2 inhibitor with a Ki of 3.8 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 607550. CAS No. 439083-90-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14992. | |
| BAY 61-3606 dihydrochloride | BAY 61-3606 dihydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM an IC50 of 10 nM[1]. BAY 61-3606 dihydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell[2]. BAY 61-3606 dihydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates[3]. Bay 61-3606 dihydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells[4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 648903-57-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14985. | |
| BAY 61-3606 hydrochloride | BAY 61-3606 hydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM. BAY 61-3606 hydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 hydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. BAY 61-3606 hydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells. Uses: Scientific research. Category: Signaling pathways. CAS No. 1615197-10-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-76474A. | |
| BAY 73-1449 | BAY 73-1449 is a selective antagonist of prostacyclin receptor (IP), with high potency (IC50 of less than 0.1 nM) in cAMP assays in Human HEL cells and rat DRG. BAY 73-1449 can be used in the research of lowering blood pressure[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 693790-96-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118941. | |
| BAY 73-6691 | BAY 73-6691 ((R)-BAY 73-6691) is a potent, brain penetrant, and selective PDE9A inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 794568-92-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104028. | |
| BAY-784 | BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1631164-24-3. Pack Sizes: 5 mg. Product ID: HY-133080. | |
| BAY-8002 | BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 724440-27-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-122312. | |
| BAY-805 | BAY-805, a chemical probe, is a selective inhibitor of ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2925481-88-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-153045. | |
| BAY-826 | BAY-826, a chemical probe, is a selective and potent TIE-2 inhibitor with a Kd of 1.6 nM, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1448316-08-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100756. | |
| BAY-850 | BAY-850, a chemical probe, is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2099142-76-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119254. | |
| BAY-85-8501 | BAY-85-8501 is a selective, reversible and potent inhibitor of Human Neutrophil Elastase (HNE), with an IC50 of 65 pM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1161921-82-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19908. | |
| BAY 87-2243 | BAY 87-2243 is a highly potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 1227158-85-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-15836. | |
| BAY-876 | BAY-876, a chemical probe, is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1799753-84-6. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-100017. | |
| BAY885 | BAY885, a chemical probe, is a highly potent and selective ERK5 inhibitor with an IC50 of 35 nM. BAY885 shows weak inhibition on others kinases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2307249-33-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112082. | |
| BAY-9835 | BAY-9835, a chemical probe, is an orally active ADAMTS7 and ADAMTS12 antagonist with IC50s of 6 nM and 30 nM, respectively. BAY-9835 exhibits inhibitory potencies vs mouse (mIC50 = 8 nM) and rat (rIC50 = 27 nM) ADAMTS7 enzymes. BAY-9835 is very selective against a range of off-targets and metalloproteases. BAY-9835 can be used for the study of atherogenesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3032487-31-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162284. | |
| BAY-985 | BAY-985, a chemical probe, is a highly potent, orally active and selective ATP-competitive dual inhibitor of TBK1 and IKKε with IC50s of 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε, respectively. Antitumor efficacy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2409479-29-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133117. | |
| Bay K 8644 | Bay K 8644 ((±)-Bay K 8644) is a racemate consisting of two isomers (R)-(+)-Bay-K-8644 and (S)-(-)-Bay-K-8644[1]. Bay K 8644 is a L-type Ca2+ channel agonist with an EC50 of 17.3 nM. Bay K 8644 increases Ca2+ influx through sarcolemmal Ca2+ channels by increasing the open time of the channel. Bay K 8644 has vasoconstrictive effects[2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-Bay K 8644. CAS No. 71145-03-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10588. | |
| BAZ1A-IN-1 | BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 941521-45-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141890. | |
| BAZ2-ICR | BAZ2-ICR is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM and 180 nM, and Kds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. BAZ2-ICR is an epigenetic chemical probe[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1665195-94-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g. Product ID: HY-19336. | |
| Bazedoxifene | Bazedoxifene (TSE-424) is an oral, BBB-penetrant nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene can be used for the research of osteoporosis. Bazedoxifene also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TSE-424. CAS No. 198481-32-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0031. | |
| Bazedoxifene acetate | Bazedoxifene acetate (TSE-424 acetate) is an oral, nonsteroidal selective estrogen receptor modulator (SERM), with IC50s of 23 nM and 99 nM for ERα and ERβ, respectively. Bazedoxifene acetate can be used for the research of osteoporosis. Bazedoxifene acetate also acts as an inhibitor of IL-6/GP130 protein-protein interactions and can be used for the research of pancreatic cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TSE-424 acetate. CAS No. 198481-33-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-A0036. | |
| BBC0403 | BBC0403 is a selective BRD2 inhibitor with Kds of 7.64 μM and 41.37 μM for BRD2 (BD2) and BRD2 (BD1), respectively. BBC0403 exhibitS higher binding specificity for BRD2 compared to BRD3 and BRD4. BBC0403 has the potential for osteoarthritis (OA) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2644662-83-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-162514. | |
| BB-Cl-Amidine | BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor. Uses: Scientific research. Category: Signaling pathways. CAS No. 1802637-39-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111347. | |
| BB-Cl-Amidine hydrochloride | BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2436747-41-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111347A. | |
| BBO-10203 | BBO-10203 is a potent inhibitor of PI3Kα and KRASG12C, selectively and covalently binding to Cys242 in the RAS-Binding Domain of PI3Kα, and inhibiting both the GTP-bound and GDP-bound states of KRASG12C with an IC50 of 0.031 nM and an EC50 of 0.02 nM. BBO-10203 disrupts the interaction between RAS isoforms and PI3Kα, leading to the inhibition of RAS-mediated PI3Kα activation, and reduces pERK expression, cell growth, and induces G1 arrest and apoptosis. BBO-10203 can be used for the research of breast cancer, colorectal cancer, and non-small cell lung cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2971769-60-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-159852. | |
| BBO-11818 | BBO-11818 is an orally active, highly selective (relative to NRAS and HRAS), non-covalent pan-KRAS inhibitor (IC50=28-120 nM). BBO-11818 specifically binds to the Switch-II/Helix 3 pocket, disrupts the KRAS:RAF1 interaction by inducing conformational changes, and blocks the MAPK signaling pathway. BBO-11818 exhibits significant anti-tumor activity, which not only inhibits cell proliferation and induces apoptosis, but also drives tumor regression in xenograft models. BBO-11818 produces synergistic effects when combined with Cetuximab (HY-P9905), anti-PD-1 antibody or PI3Kα inhibitor. BBO-11818 is used in the research of KRAS mutation-related malignancies such as pancreatic cancer, non-small cell lung cancer and colorectal cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3029443-36-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-181420A. | |
| BBO-8520 | BBO-8520 is a direct small molecule covalent inhibitor targeting KRAS G12C with high oral availability. BBO-8520 has the characteristics of KRAS G12C (OFF) inhibitor and the function of blocking KRASG12C (ON) signal. BBO-8520 inhibits cell proliferation by inhibiting KRAS G12C (ON) by binding GTP protein. BBO-8520 can block RAS-RAF1 interaction and return KRAS G12C to the inactive (OFF) state. BBO-8520 can be used for the research of cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2893809-51-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158107. | |
| BBT-176 | BBT-176 is an orally effective EGFR inhibitor. BBT-176 has inhibitory activity against multiple EGFR C797S mutant cell lines. BBT-176 is commonly used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2254805-44-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153974. | |
| BBT594 | BBT594 is a potent receptor tyrosine kinase RET inhibitor, used for cancer treatment. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NVP-BBT594. CAS No. 882405-89-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18840. | |
| BC11-38 | BC11-38 is a potent, selective, and biologically active PDE11 inhibitor, with IC50s of 0.28 μM and >100 μM for PDE11 and PDE1-10, respectively. BC11-38 elevates cAMP levels, PKA-mediated ATF-1 phosphorylation, and cortisol production in H295R cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 686770-80-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108618. | |
| BC-11 hydrobromide | BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC50=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 443776-49-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-108447. | |
| BC-1293 | BC-1293 is an inhibitor for E3 ligase subunit FBXO24. BC-1293 disrupts the interaction between FBXO24 and aspartyl-tRNA synthetase (DARS2) and increases the level of DARS2. BC-1293 increases levels of IL-1β, IL-9, MIP-2, and TNF α, and exhibits immunostimulatory activity in mice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1219395-86-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-161901. | |
| BC-1382 | BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction (IC50? 5 nM).Anti-inflammatory activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1013753-99-5. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W062696. | |
| BC-1471 | BC-1471 is a STAMBP deubiquitinase inhibitor with an IC50 of 0.33 μM. BC-1471 can inhibit the activity of the NALP7 inflammasome. BC-1471 has anti-inflammatory activity and can be used for the research of inflammatory diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 896683-84-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-122883. | |
| BC1618 | BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation). BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2222094-18-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134656. | |
| BCA | BCA (Disodium bicinchoninate) is an orally active and non-competitive Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 value of 28 μM, a Ki value of 43 μM. BCA shows anticancer activity. BCA has the potential for the research of Alzheimer's disease (AD)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Disodium bicinchoninate. CAS No. 979-88-4. Pack Sizes: 10 mM * 1 mL in Water; 5 g; 10 g; 25 g; 50 g; 100 g; 500 g; 1 k g. Product ID: HY-15908. | |
| BCATc Inhibitor 2 | BCATc Inhibitor 2 is a selective branched-chain aminotransferase (BCAT) inhibitor for research of neurodegenerative diseases. The IC50s of 0.2 μM, 0.8 μM and 3.0 μM for rat cytosolic isoenzyme rBCATc, human cytosolic isoenzyme hBCATc and rat mitochondrial isoenzyme rBCATm, respectively. BCATc, also called BCAT1, is in the cytoplasm[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 406191-34-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116044. | |
| BCAT-IN-1 | BCAT-IN-1 is a potent, selective and orally active inhibitor of BCATm, with a pIC50 of 7.3. BCAT-IN-1 shows 100-fold selectivity for BCATm over BCATc (pIC50=5.4). BCAT-IN-1 can be used for the research of metabolic diseases[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1875078-61-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141668. | |
| BCAT-IN-2 | BCAT-IN-2 is a potent, selective and orally active inhibitor of mitochondrial branched-chain aminotransferase (BCATm), with a pIC50 of 7.3. BCAT-IN-2 shows selectivity for BCATm over BCATc (pIC50=6.6). BCAT-IN-2 can be used for the research of obesity and dislipidema[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1800024-45-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141669. | |
| BCH | BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Amino-2-norbornanecarboxylic acid; LAT1-IN-1. CAS No. 20448-79-7. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg. Product ID: HY-108540. | |
| BCI | BCI ((E)-BCI) is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI can be used in inflammatory disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (E)-BCI. CAS No. 1245792-51-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115502. | |
| BCI-137 | BCI-137 is a Argonaute 2 (AGO2) inhibitor. By inhibiting AGO2 function, reducing PTPN6/SHP-1 protein levels and enhancing STAT1 phosphorylation, BCI-137 restores the sensitivity of tumor cells to IFN-γ. BCI-137 effectively enhances the recruitment, activation and cytotoxicity of CD8+ T cells. BCI-137 exerts a synergistic effect with anti-PD-1 antibodies and significantly reduces tumor volume in preclinical mouse models. BCI-137 exhibits favorable safety profiles and does not cause significant weight loss or death in mice. BCI-137 can be used in research related to bladder cancer, colorectal cancer, melanoma and other related fields[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 112170-24-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-119024. | |
| BCI-215 | BCI-215 is a potent and tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor. BCI-215 has cytotoxicity for tumor cells but not normal cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1245792-67-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121087. | |
| BCI hydrochloride | BCI ((E)-BCI) hydrochloride is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (E)-BCI hydrochloride. CAS No. 95130-23-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115502A. | |
| BCIP | BCIP(BCIP p-toluidine salt; X-phosphate p-toluidine salt) is an artificial chromogenic substrate used for the sensitive colorimetric detection of alkaline phosphatase activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BCIP p-toluidine salt; X-phosphate p-toluidine salt. CAS No. 6578-6-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-15909. | |
| BCL6-IN-13 | BCL6-IN-13 (compound I-94) inhibits BCL6 with an IC50 of 2 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2230407-20-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156595. | |
| BCL6-IN-7 | BCL6-IN-7 is a potent BCL6-corepressor interaction inhibitor[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2097518-46-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115532. | |
| BC-LI-0186 | BC-LI-0186 is a potent and selective inhibitor of Leucyl-tRNA synthetase (LRS; LeuRS) and Ras-related GTP-binding protein D (RagD) interaction (IC50=46.11 nM). BC-LI-0186 competitively binds to the RagD interacting site of LRS (Kd=42.1 nM) and has on effects on LRS-Vps34, LRS-EPRS, RagB-RagD association, mTORC1 complex formation or the activities of 12 kinases. BC-LI-0186 can effectively suppress the activity of cancer-associated?MTOR?mutants and the growth of rapamycin-resistant cancer cells.?BC-LI-0186 is a promising agent for lung cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 695207-56-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136265. | |
| BCN-CE-phosphoramidite | BCN-CE-phosphoramidite is an oligonucleotide modifier containing a BCN strained cyclooctyne structure. BCN-CE-phosphoramidite possesses bioorthogonal reactivity and bioconjugation capability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1393524-83-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W714969A. | |
| BCN-endo-PEG2-maleimide | BCN-endo-PEG2-maleimide is an ADC Linker containing 4 PEG units. BCN-endo-PEG2-maleimide contains the lyophilic bidentate macrocyclic ligand endo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, endo-BCN can react with molecules containing azide groups to form stable triazoles in the absence of catalysts. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies. Uses: Scientific research. Category: Signaling pathways. CAS No. 2675364-08-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156311. | |
| BCN-exo-PEG3-maleimide | BCN-exo-PEG3-maleimide is an ADC Linker containing 3 PEG units. BCN-exo-PEG3-maleimide contains the lyophilic bidentate macrocyclic ligand BCN, which enables the further synthesis of macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies. Uses: Scientific research. Category: Signaling pathways. CAS No. 2919127-00-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156322. | |
| BCN-exo-PEG7-maleimide | BCN-exo-PEG7-maleimide is an ADC Linker containing 7 PEG units. BCN-exo-PEG7-maleimide contains the lyophilic bidentate macrocyclic ligand BCN, which allows for further synthesis of macrocyclic complexes. In click chemistry, BCN reacts with molecules containing azide groups to form stable triazoles in the absence of catalysts. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies. Uses: Scientific research. Category: Signaling pathways. CAS No. 2143965-47-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134734. | |
| BCN-HS-PEG2(vcPABC-MMAE)2 | BCN-HS-PEG2(vcPABC-MMAE)2 is a drug-linker conjugate for ADC consists an ADC linker and a tubulin polymerization inhibitor MMAE (HY-15162). BCN-HS-PEG2(vcPABC-MMAE)2 can be used in the synthesis of antibody-agent conjugates (ADCs)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2126083-82-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-164146. | |
| BCN-linker-DXd 2 | BCN-linker-DXd 2 is an ADC linker. BCN-linker-DXd 2 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2566530-81-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-160098. | |
| BCN-OH | BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is an alcohol functionalized cyclooctyne derivative. BCN-OH can act as a raw material for synthesizing other probes (such as BCN-TPP). BCN-OH is used to construct targeted probes by coupling with carboxyl-containing compounds (such as TPP-COOH). BCN-OH can be used as control reagent for BCN-TPP[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne. CAS No. 1263166-90-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 250 mg; 1 g. Product ID: HY-W111141. | |
| BCN-PEG3-Biotin | BCN-PEG3-Biotin is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. BCN-PEG3-Biotin is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1263166-92-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130924. | |
| BCN-PEG3-OH | BCN-PEG3-OH is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. BCN-PEG3-OH is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2126749-77-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130925. | |
| BCN-PEG4-hydrazide | BCN-PEG4-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. BCN-PEG4-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 2741640-52-6. Pack Sizes: 25 mg; 50 mg. Product ID: HY-133438. | |
| BCN-PEG4-NHS ester | BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. BCN-PEG4-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1702356-19-1. Pack Sizes: 10 mg; 25 mg; 50 mg. Product ID: HY-133439. | |
| BCTC | BCTC is an orally active current inhibitor of vanilloid receptor type 1 (VR1). BCTC is a transient receptor potential cation channel subfamily M member 8 (TRPM8) and transient receptor potential vanilloid 1 (TRPV1) antagonist. BCTC is an insulin sensitizer and secretor. BCTC has anticancer and analgesic effects[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 393514-24-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19960. | |
| BCX 1470 methanesulfonate | BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin. Uses: Scientific research. Category: Signaling pathways. CAS No. 217099-44-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50875. | |
| BD-1047 dihydrobromide | BD-1047 dihydrobromide is a selective functional antagonist of sigma receptors. BD-1047 dihydrobromide attenuates Apomorphine (HY-12723)-induced climbing and Phencyclidine-induced head twitches[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 138356-21-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-16996A. | |
| BD-1063 dihydrochloride | BD-1063 dihydrochloride is a selective σ-1 receptor antagonist with inhibitory activity against TRPC5 and TRPM3. BD-1063 dihydrochloride exerts anti-hyperalgesic and anti-allodynic effects by inhibiting sustained calcium influx mediated by TRPC5 and TRPM3, and reverses the effects of Carrageenan (HY-125474). BD-1063 dihydrochloride also significantly reduces excessive ethanol self-administration behavior. BD-1063 dihydrochloride is widely used in studies on the mechanisms underlying neuropathic pain, inflammatory hyperalgesia, and alcohol abuse and dependence[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 206996-13-6. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18101A. | |
| BD750 | BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 892686-59-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131140. | |
| BD-9136 | BD-9136 is a potent and highly selective BRD4 PROTAC depressant. BD-9136 has low-nanomolar degradation potencies against BRD4 , and its degradation selectivity for BRD4 is 1000 times that of BRD2 and BRD3 proteins. BD-9136 has antitumor activity[1].(Pink: Desmethyl-QCA276 (HY-44103); Black: 3-(2-(4-Methylpiperazin-1-yl)ethyl)azetidin-3-ol; Blue: Thalidomide-4-OH (HY-103596)). Uses: Scientific research. Category: Signaling pathways. CAS No. 3037514-38-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-149878. | |
| BDC2.5 mimotope | BDC2.5 mimotope is a potent antigen-mimicking peptide that can activate CD4+ T cell populations that have the same antigen recognition properties as BDC2.5 cells. BDC2.5 mimotope can be used to study the prevention or treatment of type 1 diabetes by targeting specific T cell populations[1]. Uses: Scientific research. Category: Peptides. CAS No. 1370451-15-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P10512. | |
| BDC2.5 mimotope 1040-31 | BDC2.5 mimotope 1040-31, a BDC2.5 TCR reactive peptide, is a strong agonistic peptide for diabetogenic T cell clone BDC2.5, and the 1040-31 peptide is specific for BDC 2.5 TCR Tg+ T cells[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 329696-49-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1822. | |
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