MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| BDC2.5 Mimotope 1040-63 | BDC2.5 Mimotope 1040-63 is a biological active peptide. (The TCR transgenic model (BDC2.5) mimitope was used in type 1 diabetes (T1D) study. T1D is an autoimmune disease in which T cells mediate damage to pancreatic islet b cells. T1D is caused by autoreactive T cell destruction of insulin-producing cells. BDC2.5 mimotope was utilized to support the study on antigen presentation of antigenic peptides to islet autoantigen-specific T cells.). Uses: Scientific research. Category: Peptides. CAS No. 329696-53-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P5488. |  |
| BDM91270 | BDM91270 (compound 29) is an E. coli AcrAB-TolC efflux pump inhibitor with an EC90 of 0.6 μM for wild-type E. coli AcrB. BDM91270 can be used in the study of Escherichia coli drug resistance[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2892824-11-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155048. | |
| BD-Oligo | BD-Oligo is an oligomer-specific fluorescent chemical probe. BD-Oligo preferentially identifies Aβ oligomer assemblies over monomers or fibrils by using diversity-directed fluorescent library (DOFL) screening and computational techniques. BD-Oligo exhibits dynamic oligomer monitoring capabilities during Aβ peptide fibril formation as Aβ is induced to form oligomers and ultimately fibrils over time. BD-Oligo also exhibits blood-brain barrier permeability with the ability to stain Aβ oligomers in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1357578-02-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-171179. | |
| BDP5290 | BDP5290 is a potent inhibitor of both ROCK and MRCK with IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 1817698-21-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12437. | |
| BDP9066 | BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation. Uses: Scientific research. Category: Signaling pathways. CAS No. 2226507-04-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111424. | |
| BE2012 | BE2012, SR8278 (HY-14415) derivative, is a potent and selective REV-ERBα/β Antagonist with EC50 values of 0.285 and 0.346 μM. BE2012 binds to the ligand-binding domain (LBD) of REV-ERB, preventing the receptor from recruiting co-inhibitory factors and thereby releasing the transcriptional repression on downstream target genes. BE2012 can upregulate the expression of myogenic transcription factors Myf5 and Myod, promoting muscle regeneration and repair in acute muscle injury micemodels[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 667889-47-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-180944. | |
| Beauvericin | Beauvericin is a cyclohexapeptide Fusarium toxin with insecticidal, antibacterial, anticancer, antiviral and cytotoxic activities. Beauvericin causes cellular genotoxicity by producing DNA breaks, chromosomal aberrations and micronuclei, and inhibits the PI3K/AKT pathway to induce apoptosis, thereby inhibiting the growth of HCC. In addition, Beauvericin affects immune function by inhibiting lymphocyte proliferation and interfering with the differentiation process of human monocytes into macrophages[1][2][3][4][5][6][7][8][9]. Uses: Scientific research. Category: Signaling pathways. CAS No. 26048-05-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-N6739. | |
| BEC hydrochloride | BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 222638-67-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19548A. | |
| Beclabuvir | Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, and inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 with IC50 of < 28 nM[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BMS-791325. CAS No. 958002-33-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12429. | |
| Beclometasone | Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Beclomethasone. CAS No. 4419-39-0. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-B1540. | |
| Beclomethasone 17-propionate | Beclomethasone 17-propionate (Beclomethasone-17-monopropionate), an active metabolite of Beclomethasone dipropionate (HY-13571), is a glucocorticoid receptor (GR) agonist. Beclomethasone 17-propionate exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in chronic obstructive pulmonary disease (COPD) lung macrophages[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Beclomethasone-17-monopropionate; 17-BMP. CAS No. 5534-18-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-136239. | |
| Becotatug | Becotatug (JMT-101) is a humanized IgG1 antibody targeting EGFR. Becotatug can also be conjugated to Afatinib (HY-10261) and Osimertinib (HY-15772) as a synthetic ADC. Becotatug can be used for the study of EGFR-mutated advanced non-small cell lung cancer (NSCLC)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JMT-101; MRG003 Antibody. CAS No. 2648260-93-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P990049. | |
| Bedaquiline | Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit[1]. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TMC207; R207910. CAS No. 843663-66-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14881. | |
| Bedaquiline fumarate | Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R403323; TMC207 fumarate; R207910 fumarate. CAS No. 845533-86-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14881A. | |
| Bedaquiline (Standard) | Bedaquiline (Standard) is the analytical standard of Bedaquiline. This product is intended for research and analytical applications. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit[1]. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TMC207 (Standard); R207910 (Standard). CAS No. 843663-66-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14881R. | |
| Bederocin | Bederocin (REP8839) is a Methionyl-tRNA synthetase inhibitor. Bederocin can be used in research of bacterial infection, including S. aureus and MRSA[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REP8839. CAS No. 757942-43-1. Pack Sizes: 1 mg. Product ID: HY-14784. | |
| Bedinvetmab | Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ZTS-00508841. CAS No. 2171034-69-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99297. | |
| Beeswax | Beeswax is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Category: Signaling pathways. CAS No. 8012-89-3. Pack Sizes: 100 g; 500 g; 1 k g; 5 k g. Product ID: HY-W133974. | |
| Befiradol | Befiradol (NLX-112) is a highly selective 5-HT1A receptor agonist that acts on both presynaptic and postsynaptic sites. Befiradol attenuates fentanyl-induced respiratory depression in neonatal and adult rats. Befiradol reduces the duration of fentanyl-induced analgesia and sedation in adult rats. Befiradol can be used in studies related to opioid-induced respiratory depression[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NLX-112; F13640. CAS No. 208110-64-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14785. | |
| Befotertinib | Befotertinib (D-0316) is an orally active EGFR inhibitor and ABCB1 inhibitor. Befotertinib selectively targets EGFR mutations including EGFRT790M, EGFRL858R and delE746-A750, forms covalent bonds with EGFRC797, inhibits oncogenic signaling pathways, and exerts antiproliferative effects. Befotertinib inhibits ABCB1-mediated drug efflux, activates the ATPase activity of ABCB1, acts as a chemosensitizer and apoptosis enhancer, and restores the sensitivity of multidrug-resistant cancer cells. Befotertinib can be used in research related to multidrug-resistant cancers and non-small cell lung cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-0316. CAS No. 1835667-63-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137433. | |
| Befovacimab | Befovacimab (BAY 1093884) is a fully human monoclonal IgG2 antibody able to bind to tissue factor pathway inhibitor (TFPI). Befovacimab can be used for haemophilia A/B research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BAY 1093884. CAS No. 2156634-62-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P99465. | |
| Bekanamycin | Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic produced by Streptomyces kanamyceticus, against an array of Gram-positive and Gram-negative bacterial strain[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Kanamycin B. CAS No. 4696-76-8. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-B1174. | |
| BeKm-1 | BeKm-1 is a HERG (human ether-a-go-go-related gene) blocking compound. BeKm-1 can be used for the research of heart disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 524962-01-4. Pack Sizes: 100 μg; 500 μg; 1 mg; 5 mg. Product ID: HY-P1440. | |
| Belantamab | Belantamab (GSK2857916) is a humanized IgG1 anti-BCMA/TNFRSF17 monoclonal antibody. Belantamab is linked to MMAF (HY-15579) through a non-cleavable ADC linker to synthesize the antibody-active molecule conjugate (ADC) Belantamab mafodotin (HY-P3239). After binding to BCMA on the surface of tumor cells, Belantamab mafodotin enters the cell through receptor-mediated endocytosis. After entering the cell, Belantamab mafodotin releases MMAF, blocks cell division by inhibiting tubulin polymerization, arrests the cell cycle and induces cell apoptosis. Belantamab can be used for the study of multiple myeloma, especially relapsed/refractory multiple myeloma[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK2857914. CAS No. 2061894-48-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9980. | |
| Belantamab mafodotin | Belantamab mafodotin (GSK2857916) is composed of humanized and focused monoclonal antibody against B cell maturation antigen (BCMA) and McMMAF. The antibody portion is Belantamab (HY-P9980), and the drug-linker conjugate for ADC is McMMAF (HY-15578). Belantamab mafodotin has anti-myeloma activity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GSK2857916; Belantamab mafodotin-blm. CAS No. 2050232-20-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P3239. | |
| Belapectin | Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Ki of 2.8 μM[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GR-MD-02. CAS No. 1980787-47-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114440. | |
| Belatacept | Belatacept (BMS 224818) is a selective T-cell costimulation blocker and a costimulator of the CD28-CD80/86 pathway. Belatacept binds to the CD 80/86 ligand and inhibits CD-28-mediated T cell costimulation and IFN-γ production. Belatacept can be used in studies of immunosuppression in organ transplantation[1][2]. The component ratio of this product is Active ingredient : Excipients = 1:2.4. Uses: Scientific research. Category: Inhibitory antibodies. Alternative Names: BMS 224818; LEA 29Y. CAS No. 706808-37-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-108813. | |
| Belimumab | Belimumab (LymphoStat B) is a humanized IgG1λ monoclonal antibody against B-lymphocyte stimulator (BLyS) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research[1][2][3][4]. The component ratio of this product is Active ingredient: Excipients = 1:1.0-1:1.2. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LymphoStat B. CAS No. 356547-88-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P9952. | |
| Belinostat | Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PXD101; PX105684. CAS No. 866323-14-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10225. | |
| Belnacasan | Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: VX-765. CAS No. 273404-37-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13205. | |
| Belotecan | Belotecan (CKD-602 free base) is a DNA topoisomerase I inhibitor. Belotecan induces cell apoptosis and cell-cycle arrest. Belotecan is a camptothecin analogue with anti-tumor effects, it can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CKD-602 free base. CAS No. 256411-32-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-13566. | |
| Belotecan hydrochloride | Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CKD-602. CAS No. 213819-48-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13566A. | |
| Belrestotug | Belrestotug (EOS-448) is an antagonistic anti-TIGIT (VSIG9, VSTM3) human immunoglobulin G1 kappa (hIgG1 kappa) antibody. Belrestotug shows antineoplastic activity. Belrestotug can be used for cancer and immunological research such as colon cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: EOS-448; EOS884448; GSK4428859A. CAS No. 2574438-65-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990032. | |
| Belumosudil | Belumosudil (KD025) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KD025; SLx-2119. CAS No. 911417-87-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-15307. | |
| Belumosudil mesylate | Belumosudil mesylate (KD025 mesylate) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KD025 mesylate; SLx-2119 mesylate. CAS No. 2109704-99-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15307A. | |
| Belvarafenib | Belvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HM95573; GDC-5573; RG6185. CAS No. 1446113-23-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109080. | |
| Belzutifan | Belzutifan (PT2977) is an orally active and selective HIF-2α inhibitor with an IC50 of 9 nM. Belzutifan, as a second-generation HIF-2α inhibitor, increases potency and improves pharmacokinetic profile. Belzutifan is a potential treatment for clear cell renal cell carcinoma (ccRCC)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PT2977; MK-6482. CAS No. 1672668-24-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125840. | |
| Bemarituzumab | Bemarituzumab is a humanized IgG1 monoclonal antibody against FGFR2b (a FGF receptor). Bemarituzumab blocks fibroblast growth factors from binding and activating FGFR2b. Bemarituzumab has antitumor activity against gastric and breast cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1952272-74-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99010. | |
| Bemcentinib | Bemcentinib (R428) is a selective and orally active Axl inhibitor with an IC50 of 14 nM. Bemcentinib retards cancer cell migration and invasion. Bemcentinib exhibits >100-fold selectivity for Axl versus Abl and 50- and >100-fold selectivity over TAM family kinases Mer and Tyro3, respectively, in cells. Bemcentinib blocks tumor spread and prolongs survival in models of metastatic breast cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: R428; BGB324. CAS No. 1037624-75-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15150. | |
| Bemnifosbuvir | Bemnifosbuvir (AT-511) is a potent and orally active HCV viral replication inhibitor. Bemnifosbuvir is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM). Bemnifosbuvir has pangenotypic antiviral activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AT-511. CAS No. 1998705-64-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137958A. | |
| Bemnifosbuvir hemisulfate | Bemnifosbuvir hemisulfate (AT-527), a hemisulfate salt of AT-511, a guanosine nucleotide proagent, is a potent and orally active HCV viral replication inhibitor. Bemnifosbuvir hemisulfate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM). Bemnifosbuvir hemisulfate has pangenotypic antiviral activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AT-527. CAS No. 2241337-84-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137958. | |
| Bempedoic acid | Bempedoic acid (ETC-1002) is an ATP-citrate lyase (ACL) inhibitor[1]. Bempedoic acid (ETC-1002) activates AMPK[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ETC-1002; ESP-55016. CAS No. 738606-46-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-12357. | |
| Bempikibart | Bempikibart (ADX-914) is a fully human anti-IL-7Rα antibody that re-regulates adaptive immune function by blocking signaling mediated by both IL-7 and thymic stromal lymphopoietin (TSLP). Bempikibart can be used for the study of atopic dermatitis and alopecia areata[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ADX-914. CAS No. 2622254-57-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990023. | |
| Benarthin | Benarthin is an orally active Pyroglutamyl peptidase inhibitor, THY1 inhibitor (with a Kd value of 5.13e-08 M) and competitive PGP-1 inhibitor (Ki = 1.2 μM). Benarthin is isolated from the culture broth of Streptomyces xanthophaeus MJ244-SF1. Benarthin disrupts the THY1-SFRP1 interaction, inhibits the activation of the GSK3α/β-β-catenin pathway, and reduces the upregulation of FASLG. Benarthin attenuates urothelial anoikis and reduces cell Apoptosis. Benarthin possesses iron-chelating activity. Benarthin maintains urothelial barrier integrity and blocks the pathological cascade of renal interstitial fibroblasts induced by HAP stimulation. Benarthin can be used in studies related to kidney stones[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 143651-45-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-117738. | |
| Bendamustine | Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SDX-105 free base. CAS No. 16506-27-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13567. | |
| Bendamustine hydrochloride | Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SDX-105. CAS No. 3543-75-7. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-B0077. | |
| Bendroflumethiazide | Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Bendrofluazide. CAS No. 73-48-3. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg. Product ID: HY-B1363. | |
| Benfluorex hydrochloride | Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JP-992 hydrochloride. CAS No. 23642-66-2. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-B1058. | |
| Benidipine hydrochloride | Benidipine hydrochloride is an orally active calcium channel antagonist. Benidipine hydrochloride can inhibit cell proliferation and apoptosis. Benidipine hydrochloride has antioxidant activity and can increase nitric oxide synthase activity and improve coronary circulation in hypertensive rats[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KW-3049. CAS No. 91599-74-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B1448. | |
| Benitrobenrazide | Benitrobenrazide (BNBZ) is the orally active inhibitor for hexokinase 2 with an IC50 of 0.53 μM. Benitrobenrazide causes DNA damage, and exhibits antitumor effect[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BNBZ; Hexokinase 2 inhibitor 1. CAS No. 2454676-05-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134929. | |
| Benoxaprofen | Benoxaprofen (LRCL 3794) is a nonsteroidal anti-inflammatory agent that blocks the biosynthesis of inflammatory mediators such as leukotrienes and prostaglandins by inhibiting 5-LOX, PGH2 synthase and cytochrome P-450. Benoxaprofen exhibits significant toxicity: it not only alters cellular redox status, uncouples oxidative phosphorylation and disrupts calcium ion homeostasis, but also causes liver injury through the formation of covalent adducts between its active metabolites and hepatic proteins. Benoxaprofen shows strong phototoxicity under ultraviolet irradiation, and induces erythrocyte lysis, mast cell degranulation and histamine release. Benoxaprofen is widely used in studies of urticaria and related phototoxic mechanisms[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LRCL 3794. CAS No. 51234-28-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13568. | |
| Benperidol | Benperidol is a relatively old antipsychotic agent. Benperidol is a butyrophenone antipsychotic, with the highest neuroleptic potency in terms of D2 receptor blockade[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2062-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-121276. | |
| Benproperine phosphate | Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate has the potential for a cough suppressant and suppresses cancer cell migration and tumor metastasis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 19428-14-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-114657A. | |
| Benpyrine | Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2550398-89-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133807. | |
| Benralizumab | Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MEDI-563; BIW-8405; KHK4563. CAS No. 1044511-01-4. Pack Sizes: 1 mg; 2 mg. Product ID: HY-P9923. | |
| Benralizumab (anti-IL5RA ) | Benralizumab (anti-IL5RA ) (MEDI-563 (anti-IL5RA ); BIW-8405 (anti-IL5RA)) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma study [1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MEDI-563 (anti-IL5RA ); BIW-8405 (anti-IL5RA ). CAS No. 1044511-01-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9923A. | |
| Benserazide | Benserazide is an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor. Benserazide is also a PKM2 inhibitor. Benserazide directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide can be used for the study of Parkinson's disease and melanoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ro 4-4602. CAS No. 322-35-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-121275. | |
| Benserazide hydrochloride | Benserazide hydrochloride (Serazide) is an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor. Benserazide hydrochloride is also a PKM2 inhibitor. Benserazide hydrochloride directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide hydrochloride can be used for the study of Parkinson's disease and melanoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ro 4-4602 hydrochloride. CAS No. 14919-77-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0404A. | |
| Bentamapimod | Bentamapimod (AS 602801) is an ATP-competitive JNK inhibitor with IC50 of 80 nM, 90 nM, and 230 nM for JNK1, JNK2, and JNK3, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AS 602801. CAS No. 848344-36-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-14761. | |
| Bentazone-d7 | Bentazone-d7 is the deuterium labeled Bentazone[1]. Bentazone is a post-emergence herbicide used for selective control of broadleaf weeds and sedges in beans, rice, corn, peanuts, mint and others. It acts by interfering with photosynthesis[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 131842-77-8. Pack Sizes: 1 mg. Product ID: HY-B2039S1. | |
| Bentazone (Standard) | Bentazone (Standard) is the analytical standard of Bentazone. This product is intended for research and analytical applications. Bentazone is a post-emergence herbicide used for selective control of broadleaf weeds and sedges in beans, rice, corn, peanuts, mint and others. It acts by interfering with photosynthesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 25057-89-0. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B2039R. | |
| Benufutamab | Benufutamab (GEN1029) is a death receptor 5 (DR5)-specific agonistic antibody. Benufutamab is a mixture of 2 noncompeting DR5-specific IgG1 antibodies, each with an E430G mutation in the Fc domain. Benufutamab has antitumor effects[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GEN1029. CAS No. 2109730-69-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99470. | |
| Benzaldehyde-PEG4-azide | Benzaldehyde-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Benzaldehyde-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 1151451-77-2. Pack Sizes: 100 mg; 250 mg; 1 g. Product ID: HY-133455. | |
| Benzalkonium chloride (51% in water) | Benzalkonium (Alkyldimethylbenzylammonium) chloride (51% in water) is a quaternary ammonium preservative, cationic surfactant, and antimicrobial (Antimicrobial) agent. Benzalkonium chloride (51% in water) is toxic[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Alkyldimethylbenzylammonium chloride. CAS No. 8001-54-5. Pack Sizes: 50 mg (510 mg * mL * 98 μL in Water). Product ID: HY-B2232. | |
| Benzamil hydrochloride | Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Benzylamiloride hydrochloride. CAS No. 161804-20-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1546A. | |
| Benzbromarone | Benzbromarone is an orally active anti-gout agent. Benzbromarone has anti-infammatory, anti-oxidative stress and nephroprotective effects. Benzbromarone can be used for the research of hyperuricemia and gout[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3562-84-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-B1135. | |
| Benzethonium chloride | Benzethonium chloride inhibits nicotinic acetylcholine receptors in human recombinant α7 and α4β2 neurons in Xenopus laevis oocytes, which has antibacterial, anticancer, antisepsis and disinfection activity. Benzethonium chloride induced Apoptosis and activated caspases in cancer cell lines. Benzethonium chloride ablates the tumor-forming ability of FaDu cells, delays the growth of xenograft tumors in vivo[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 121-54-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B0942. | |
| Benzo[a]pyrene | Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies. Uses: Scientific research. Category: Induced disease models products. Alternative Names: 3,4-Benzopyrene. CAS No. 50-32-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-107377. | |
| Benzobicyclon | Benzobicyclon is a 4-HPPD inhibitor and herbicide that reacts with water to form a hydrolysate of the active herbicide benzobicycline, causing bleaching and death of weeds. Benzobicyclon is effective against grass, sedge and broadleaf weeds. Benzobicyclon effectively targets sulfonylurea herbicide-resistant biotypes as well as wild-type weeds[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 156963-66-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118742. | |
| Benzocaine | Benzocaine is an orally active local anesthetic. Benzocaine non-competitively inhibits the binding of Ca-ATPase to Ca2+, with an IC50 of 47.1 mM. Benzocaine exerts anesthetic effects by blocking voltage-gated sodium channels. Benzocaine induces methemoglobinemia in various experimental animals[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 94-09-7. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-Y0258. | |
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