MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Cenicriviroc | Cenicriviroc (TAK-652) is an orally active, dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAK-652; TBR-652. CAS No. 497223-25-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14882. |  |
| Cenicriviroc Mesylate | Cenicriviroc Mesylate (TAK-652 Mesylate) is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TAK-652 Mesylate; TBR-652 Mesylate. CAS No. 497223-28-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14882A. | |
| Cenisertib | Cenisertib (AS-703569) is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AS-703569; R-763. CAS No. 871357-89-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13072. | |
| Censavudine | Censavudine (OBP-601; BMS-986001), a nucleoside analog, is a nucleoside reverse transcriptase inhibitor. Censavudine is a potent HIV inhibitor with EC50 ranges from 30 nM to 81 nM and 450 nM to 890 nM for HIV-2 and HIV-1, respectively[1][2]. Censavudine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Festinavir; BMS-986001; OBP-601. CAS No. 634907-30-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16776. | |
| Centrinone | Centrinone (LCR-263) is a selective and reversible inhibitor of polo-like kinase 4 (PLK4) with a Ki of 0.16 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LCR-263. CAS No. 1798871-30-3. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18682. | |
| Centrinone-B | Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LCR-323. CAS No. 1798871-31-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18683. | |
| Cenupatide | Cenupatide (UPARANT) is a Urokinase-type plasminogen activator receptor (uPAR) inhibitor. Cenupatide has anti-angiogenic and anti-inflammatory efficacy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1006388-38-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1615. | |
| Cenvacibart | Cenvacibart is a monoclonal antibody with anticoagulant activity, targeting human coagulation factor XI (F11). Cenvacibart blocks the role of coagulation factor XI in the coagulation cascade, reducing thrombus formation. Cenvacibart is promising for research of thrombotic diseases[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REGN-7508. CAS No. 3008610-21-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P991124. | |
| CEP-11981 | CEP-11981(ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI), which can target TIE2, VEGFR1-3 and FGFR1, and has potential anti-tumor and anti-angiogenic effects[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ESK981; BOL 303213X. CAS No. 856691-93-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-16135. | |
| CEP-1347 | CEP-1347 is an inhibitor of the JNK/SAPK pathway with neuroprotective effects. CEP-1347 blocks JNK1 activation induced by members of the mixed lineage kinase (MLK) family (MLK3, MLK2, MLK1, dual leucine zipper kinase, and leucine zipper kinase). As an inhibitor of MDM4, CEP-1347 can more effectively inhibit the growth of glioma cells expressing wild-type p53[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: KT7515. CAS No. 156177-65-0. Pack Sizes: 1 mg. Product ID: HY-10412. | |
| CEP-33779 | CEP-33779 is a novel, selective, and orally bioavailable inhibitor of JAK2 with an IC50 of 1.8±0.6 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1257704-57-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15343. | |
| CEP-37440 | CEP-37440 is a potent, orally active dual FAK/ALK inhibitor with IC50 values of 2.3 nM and 3.5 nM for FAK and ALK, respectively. CEP-37440 decreases the cell proliferation by blocking the autophosphorylation kinase activity of FAK1 (Tyr 397)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1391712-60-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15841. | |
| CEP-40783 | CEP-40783 is a potent, selective and orally available inhibitor of AXL and c-Met with IC50 values of 7 nM and 12 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RXDX-106. CAS No. 1437321-24-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-100946. | |
| Ceperognastat | Ceperognastat (LY3372689) is an orally active O-GlcNAcase (OGA) enzyme inhibitor. Ceperognastat can be used for tauopathies research, including Alzheimers disease[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY3372689. CAS No. 2241514-56-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144681. | |
| Cephaeline | Cephaeline ((-)-Cephaeline), a desmethyl analog of Emetine, is a phenolic alkaloid in Indian Ipecac roots isolated from the Cephaelis ipecacuanha. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections. Cephaeline is an inductor of histone H3 acetylation and an inhibitor of mucoepidermoid carcinoma cancer stem cells (MEC), which promotes ferroptosis by inhibiting NRF2 to exert anti-lung cancer efficacy[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Cephaeline; NSC 32944 free base. CAS No. 483-17-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N4118. | |
| Cephaeline dihydrochloride | Cephaeline dihydrochloride is a selective CYP2D6 inhibtor with an IC50 of 121 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Cephaeline dihydrochloride; NSC 32944. CAS No. 5853-29-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2260. | |
| Cephalexin | Cephalexin (Cefalexin) is a potent, orally active semisynthetic cephalosporin antibiotic with a broad antibacterial spectrum. Cephalexin has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. Cephalexin targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall assembly. Cephalexin is used for the research of pneumonia, strep throat, and bacterial endocarditis, et al[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cefalexin; Cephacillin. CAS No. 15686-71-2. Pack Sizes: 10 mM * 1 mL in Water; 1 g; 5 g; 10 g. Product ID: HY-B0200. | |
| Cephaloridine hydrate | Cephaloridine hydrate is a broad-spectrum antibacterial antibiotic. Cephaloridine has certain dose-related nephrotoxicity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 102039-86-1. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg. Product ID: HY-B2072A. | |
| Cephalosporin C | Cephalosporin C has weak resistance to Gram-positive and negative bacteria, is stable to penicillinase, and can be broken down by cephalosporin enzyme. Hydrolysis and removal of side chains to obtain 7-amino-cefenoic acid (7-ACA) is an important raw material for the preparation of semi-synthetic cephalosporin[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 61-24-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1299. | |
| Cephapirin sodium | Cephapirin sodium (Cefapirin sodium) is an ephalosporin antibiotic with broad-spectrum antimicrobial activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cefapirin sodium. CAS No. 24356-60-3. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg. Product ID: HY-A0153A. | |
| Cepharanthine | Cepharanthine is a natural product that can be isolated from the plant Stephania cephalantha Hayata. Cepharanthine has anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) activities. Cepharanthine has good effective in suppressing viral proliferation (half maximal (50%) inhibitory concentration (IC50) and 90% inhibitory concentration (IC90) values of 1.90 and 4.46 μM[1]. Cepharanthine can also effectively reverses P-gp-mediated multidrug resistance in K562 cells and increase enhances the sensitivity of anticancer agents in xenograft mice model[2][3]. Cepharanthine shows inhibitory effects of human liver cytochrome P450 enzymes CYP3A4, CYP2E1 and CYP2C9. Cepharanthine has antitumor, anti-inflammatory and antinociceptive effects[4][5][6][7][8]. Uses: Scientific research. Category: Signaling pathways. CAS No. 481-49-2. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-N6972. | |
| CER10-d9 | CER10-d9 is deuterium labeled CER10. Uses: Scientific research. Category: Signaling pathways. CAS No. 2260669-52-9. Pack Sizes: 1 mg. Product ID: HY-146828S. | |
| Ceralasertib | Ceralasertib (AZD6738) is an orally active and bioavailable inhibitor of ATR kinase with an IC50 of 1 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AZD6738. CAS No. 1352226-88-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-19323. | |
| Ceramide 1-phosphate | Ceramide 1-phosphate is a bioactive lipid and one of the key components of sphingolipids. Ceramide 1-phosphate playing diverse roles in cellular behaviors such as cell differentiation, migration, proliferation and death[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 128543-23-7. Pack Sizes: 1 mg. Product ID: HY-P2982. | |
| Ceramide 3-d3 | Ceramide 3-d3 (N-Stearoyl phytosphingosine-d3) is deuterium labeled Ceramide 3. Ceramide 3 is an orally active major component of intercellular lipids in the stratum corneum of the skin, and belongs to the ceramide family. Ceramide 3 inhibits c-jun and NF-κB activation induced by Histamine (HY-B1204), and suppresses the expression of IL-4 and TNF-α. Ceramide 3 inhibits scratching behavior and vascular permeability in mice, and exhibits antihistamine effects in guinea pig ileum. Ceramide 3 improves skin barrier function, reduces transepidermal water loss, erythema and the number of circulating epidermal cells, and accelerates barrier repair of irritated or dysfunctional skin. Uses: Scientific research. Category: Signaling pathways. Alternative Names: N-Stearoyl phytosphingosine-d3. CAS No. 1354806-91-9. Pack Sizes: 1 mg. Product ID: HY-141582S. | |
| Ceranib1 | Ceranib1 is a ceramidase inhibitor. Ceranib1 inhibits ceramidase activity toward an exogenous ceramide analog, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P. Ceranib1 inhibits the proliferation of ovarian cancer cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 328076-61-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103359. | |
| Ceranib-2 | Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and induces cell apoptosis. Anticancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1402830-75-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116147. | |
| Cerdulatinib | Cerdulatinib (PRT062070) is a selective Tyk2 inhibitor with an IC50 of 0.5 nM. Cerdulatinib (PRT062070) also is a dual JAK and SYK inhibitor with IC50s of 12, 6, 8 and 32 for JAK1, 2, 3 and SYK, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PRT062070; PRT2070. CAS No. 1198300-79-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15999. | |
| Cerebroside B | Cerebroside B, a sphingolipid compound, is a non-racespecific elicitor, which elicits defense responses in rice[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 88642-46-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N3570. | |
| Cereulide | Cereulide is an orally active, blood-brain barrier-permeable emetic toxin. Cereulide acts as a potassium ionophore that inserts into membranes, forms complexes with K+, and transports K+ from the cytoplasm into the mitochondrial matrix. Cereulide disrupts the electrochemical gradient of the inner mitochondrial membrane, leading to mitochondrial swelling and dysfunction, uncoupling of oxidative phosphorylation, inhibition of ATP synthesis, ROS accumulation, and ultimately triggering apoptosis and autophagy. Cereulide exhibits multi-organ toxicity and can be used for research on emetic food poisoning[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 157232-64-9. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-P3003. | |
| Cereulide-13C6 | Cereulide-13C6 is a deuterated form of Cereulide. Cereulide is an orally active, blood-brain barrier-permeable emetic toxin. Cereulide acts as a potassium ionophore that inserts into membranes, forms complexes with K+, and transports K+ from the cytoplasm into the mitochondrial matrix. Cereulide disrupts the electrochemical gradient of the inner mitochondrial membrane, leading to mitochondrial swelling and dysfunction, uncoupling of oxidative phosphorylation, inhibition of ATP synthesis, ROS accumulation, and ultimately triggering apoptosis and autophagy. Cereulide exhibits multi-organ toxicity and can be used for research on emetic food poisoning. Uses: Scientific research. Category: Signaling pathways. CAS No. 1487375-69-8. Pack Sizes: 20 μg (17.25 μM * 1 mL in Acetonitrile). Product ID: HY-P3003S. | |
| Cerevisterol | Cerevisterol is a steroid isolated from the fruiting bodies of Agaricus blazei[1]. Uses: Scientific research. Category: Natural products. CAS No. 516-37-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N3571. | |
| Cergutuzumab amunaleukin | Cergutuzumab amunaleukin (CEA-IL2v) is a monomeric carcinoembryonic antigen (CEA)-targeted IL-2 variant-based immunocytokine. Cergutuzumab amunaleukin has immunostimulating and antineoplastic activities[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CEA-IL2v; RG 7813; RO 6895882. CAS No. 1509916-03-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99498. | |
| Ceritinib | Ceritinib (LDK378) is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib shows great antitumor potency[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LDK378. CAS No. 1032900-25-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g; 5 g. Product ID: HY-15656. | |
| Ceritinib dihydrochloride | Ceritinib (LDK378) dihydrochloride is a selective, orally bioavailable and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib dihydrochloride also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib dihydrochloride shows great antitumor potency[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LDK378 dihydrochloride. CAS No. 1380575-43-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15656A. | |
| Cerivastatin sodium | Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 143201-11-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109523. | |
| Certepetide | Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1, and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors, and is used in the research of pancreatic cancer and other solid tumors[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CEND-1; iRGD; LSTA1. CAS No. 2580154-02-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3448. | |
| Certolizumab pegol | Certolizumab pegol (Certolizumab) is a recombinant, polyethylene glycosylated, antigen-binding fragment of a humanized monoclonal antibody that selectively targets and neutralizes tumour necrosis factor-α (TNF-α). Certolizumab pegol can be used for rheumatoid arthritis and Crohn disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Certolizumab; CDP870. CAS No. 428863-50-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9953. | |
| Cerulenin | Cerulenin, a potent, natural inhibitor of fatty acid synthase (FASN), is an epoxide produced by the fungus Cephalosporium caeruleus. Cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. Cerulenin has antifungal and antitumor activies[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 17397-89-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-A0210. | |
| Cesium chloride | Cesium chloride is a blocker of potassium channel. Cesium chloride prevents the decrease of Na+ transport produced by Alloxan[1][2]. Cesium chloride has induced cardiac arrhythmias, including torsade de pointes in animal models[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7647-17-8. Pack Sizes: 10 mM * 1 mL in Water; 5 g; 10 g; 25 g; 50 g; 100 g; 500 g. Product ID: HY-107754. | |
| Cethromycin | Cethromycin (ABT-773) is a ketolide antibiotic[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ABT-773; Abbott-195773; A-195773. CAS No. 205110-48-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-19655. | |
| Cetirizine | Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 83881-51-0. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-17042. | |
| Cetirizine dihydrochloride | Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine dihydrochloride marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: P071. CAS No. 83881-52-1. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg. Product ID: HY-17042A. | |
| Cetoleic acid | Cetoleic acid is a long-chain monounsaturated fatty acid found in deep-sea fish. Cetoleic acid can promote the synthesis of ALA in human HepG2 cells and EPA in vitro in salmon liver cells, affecting cholesterol levels in rodents. Cetoleic acid has potential applications in cardiovascular disease research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1002-96-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-113000. | |
| Cetrelimab | Cetrelimab (JNJ 63723283; JNJ 3283) is a human IgG4κ mAb targeting PD-1. Cetrelimab binds PD-1 (Kd=1.72 nM, HEK293) to block the interaction of PD-1 with PD-L1 and PD-L2 (IC50s=111.7 ng/mL and 138.6 ng/mL, respectively). Cetrelimab stimulates peripheral T cells, increases IFN-γ, IL-2, TNF-α level and inhibits tumor growth in vivo[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: JNJ 63723283; JNJ 3283. CAS No. 2050478-92-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99499. | |
| Cetrimonium bromide | Cetrimonium bromide (CTAB), a quaternary ammonium, is an orally active cationic surfaetant. Cetrimonium bromide has toxicity and anticancer effect. Cetrimonium bromide inhibits cell migration and invasion through modulating the canonical and non-canonical TGF-β signaling pathways. Cetrimonium bromide can be used for DNA extraction[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CTAB; Cetyltrimethylammonium bromide; Hexadecyltrimethylammonium bromide. CAS No. 57-09-0. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-B1260. | |
| Cetrorelix Acetate | Cetrorelix Acetate (SB-75 acetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SB-75 acetate. CAS No. 145672-81-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0009A. | |
| Cetuximab | Cetuximab (C225) is a human IgG1 monoclonal antibody that inhibits epidermal growth factor receptor (EGFR), with a Kd of 0.201 nM for EGFR by SPR. Cetuximab has potent antitumor activity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: C225; IMC-C225. CAS No. 205923-56-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P9905. | |
| Cetyl tranexamate hydrochloride | Cetyl tranexamate (TXC) hydrochloride is an ester derivative of Tranexamic acid (HY-B0149). Cetyl tranexamate hydrochloride is an inhibitor of fibrinogen activation and can reduce the production of fibrinogen in keratinocytes induced by ultraviolet rays or damage, indirectly inhibiting the melanin production pathway. Cetyl tranexamate hydrochloride also targets melanin (dark spots) and hemoglobin (red spots), reducing vascular dilation and pigmentation by inhibiting inflammatory mediators (such as prostaglandins, platelet activating factors). Cetyl tranexamate hydrochloride can be used as a cosmetic ingredient and is suitable for epidermal pigment disorders such as photoaging, post-inflammatory hyperpigmentation (PIH), and melasma[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TXC hydrochloride. CAS No. 913541-96-5. Pack Sizes: 1 g; 5 g; 10 g. Product ID: HY-148400. | |
| Cevidoplenib | Cevidoplenib (SKI-O-703) is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. Cevidoplenib is also the mesylate form of SKI-O-592. Cevidoplenib and SKI-O-592 inhibits BCR-mediated survival, proliferation, and differentiation of B cells. And SKI-O-592 potently inhibits multiple kinases with IC50s of 6.2 nM (Syk), 1.859 μM (Jak2), 5.807 μM (Jak3), 0.412 μM (RET), 0.687 μM (KOR), 1.783 μM (FLT3), 16.96 μM (FGFR1), 5.662 μM (FGFR3), and 0.709 μM (Pyk2), respectively[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SKI-O-703. CAS No. 1703788-21-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109082. | |
| Cevimeline hydrochloride | Cevimeline hydrochloride (AF102B hydrochloride) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia[1][2][3][4]. Cevimeline hydrochloride can cross the blood-brain barrier (BBB)[5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AF102B hydrochloride. CAS No. 107220-28-0. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-70020B. | |
| Cevimeline hydrochloride hemihydrate | Cevimeline hydrochloride hemihydrate (SNI-2011) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline hydrochloride hemihydrate stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia[1][2][3][4]. Cevimeline hydrochloride hemihydrate can cross the blood-brain barrier (BBB)[5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SNI-2011; AF102B hydrochloride hemihydrate. CAS No. 153504-70-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-76772. | |
| Cevipabulin | Cevipabulin (TTI-237) is an oral, microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: TTI-237. CAS No. 849550-05-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14949. | |
| Cevostamab | Cevostamab (BFCR4350A; RG6160; RO7187797) is a humanized IgG1-based BsAb that targets membrane-proximal extracellular domain of FcRH5 on multiple myeloma (MM) cells as well as CD3 on T cells. Moreover, Cevostamab facilitates efficient synapse formation, improves killing activity of T cells against MM tumor cells[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BFCR 4350A; RG 6160; RO 7187797. CAS No. 2249888-53-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99601. | |
| CFDA-SE | CFDA-SE is a fluorescent dye that can penetrate the cell membrane. It can react with the free amine group in the cytoskeleton protein inside the cell, and finally form a protein complex with fluorescence. After entering the cell, CFDA-SE locates in the cell membrane, cytoplasm and nucleus, and the fluorescence staining is strongest in the nucleus[1]. CFDA-SE dye can be uniformly inherited by the cells with cell division and proliferation, and its attenuation is proportional to the number of cell divisions. This phenomenon can be detected and analyzed by flow cytometry under the excitation light of 488 nm, and can be used to detect the proliferation of cells[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CFSE; 5(6)-Carboxyfluorescein diacetate succinimidyl ester; 5(6)-CFDA N-succinmidyl ester. CAS No. 150347-59-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-D0938. | |
| c-Fms-IN-1 | c-Fms-IN-1 is a FMS kinase inhibitor with an IC50 of 0.0008 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 885703-64-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18791. | |
| c-Fos-IN-1 | c-Fos-IN-1 (Compound P16) is a c-Jun inhibitor, and decreases mRNA levels and protein levels of c-Fos. c-Fos-IN-1 also inhibits the phosphorylation activity of ERK and the transcriptional activity of AP-1. c-Fos-IN-1 shows anticancer activity by inhibiting ERK/c-Fos/Jun pathway. c-Fos-IN-1 inhibits the proliferation and migration of gastric cancer cells (IC50: 2.31 μM for MGC-803 cell). c-Fos-IN-1 arrests cell cycle at G2/M phase and induces cancer cell apoptosis. c-Fos-IN-1 inhibits gastric cancer tumor growth[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3125025-31-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-168895. | |
| CFT-1297 | CFT-1297 is a BET PROTAC degrader that can degrade BRD4[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2154353-03-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-168546. | |
| CFT8634 | CFT8634 is an orally bioavailable PROTAC BRD9 targeted degrader based on the E3 ubiquitin ligase CRBN mechanism. CFT8634 can be used for the study of synovial sarcoma and SMARCB1-deficient solid tumors (Pink: BRD9 ligand (HY-169988); Blue: E3 ligase ligand (HY-169989); Black: linker (HY-169991). CFT8634 is a heterobifunctional molecule that binds to BRD9 at one end and recruits CRBN at the other end, which can inhibit the growth of tumor cells that depend on BRD9. CFT8634 can be used for the study of SMARCB1-related cancers (such as synovial sarcoma and malignant rhabdoid tumor)[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2704617-96-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145925B. | |
| CFTR activator 1 | CFTR activator 1 is a potent and selective CFTR activator, with an EC50 of 23 nM. CFTR activator 1 can be used to ameliorate dry eye disease[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2768261-09-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152264. | |
| CFTR corrector 4 | CFTR corrector 4 (Compound 13), an active (R,R)-form enantiomer, is a highly potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. CFTR corrector 4 can increase CFTR levels at the cell surface and have the potential for treatment of cystic fibrosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1918142-34-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135279. | |
| CFTR corrector 6 | CFTR corrector 6 is a potent potentiator of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR corrector 6 has the potential for cystic fibrosis (CF) and other CFTR associated disorders research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2226970-01-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-136939. | |
| CFTR corrector 8 | CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1918142-35-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147249. | |
| CFTR(inh)-172 | CFTR(inh)-172 is a potent and selective blocker of the CFTR chloride channel; reversibly inhibits CFTR short-circuit current in less than 2 minutes with a Ki of 300 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 307510-92-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16671. | |
| CG428 | CG428 is a potent and selective CRBN-dependent tropomyosin receptor kinase (TRK) PROTAC degrader that has anti-tumor activity. CG428 reduces levels of the tropomyosin 3 TPM3-TRKA fusion protein in KM12 colorectal carcinoma cells (DC50 = 0.36 nM) and inhibits downstream PLCγ1 phosphorylation (IC50 = 0.33 nM). CG428 has a higher binding affinity for TRKA than TRKB and TRKC (Kd = 1 nM, 28 nM and 4.2 nM, respectively). CG428 can be used for the research of colorectal carcinoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2412055-93-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-137465. | |
| cGAMP | cGAMP (Cyclic GMP-AMP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cyclic GMP-AMP; 3',3'-cGAMP. CAS No. 849214-04-6. Pack Sizes: 10 mM * 1 mL in Water; 500 μg; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-12512. | |
| cGAMP disodium | cGAMP (Cyclic GMP-AMP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cyclic GMP-AMP disodium; 3',3'-cGAMP disodium. CAS No. 2407516-83-8. Pack Sizes: 10 mM * 1 mL in Water; 500 μg; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-110385. | |
| cGAS-IN-2 | cGAS-IN-2 (compound 109) is a potent inhibitor of Cyclic GMP-AMP Synthase (cGAS), with IC50 of 0.01512 μM for h-cGAS[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2765273-11-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160546. | |
| cGAS-IN-4 | cGAS-IN-4 (Compound 36) is an orally active inhibitor for cyclic GMP-AMP synthase (cGAS) with IC50 of 32 nM and 5.8 nM for h-cGAS and m-cGAS. cGAS-IN-4 inhibits the cGAMP in THP-1 cell with an IC50 of 60 nM, which improves the cellular potency. cGAS-IN-4 exhibits anti-inflammatory efficacy in Concanavalin A (HY-P2149)-induced acute liver injury in mouse models[1].orally active, THP-1, C57Bl/6 mouse, orally active. Uses: Scientific research. Category: Signaling pathways. CAS No. 2987886-49-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-170362. | |
| CGK733 | CGK733 is a potent ATM/ATR inhibitor, used for the research of cancer. Uses: Scientific research. Category: Signaling pathways. CAS No. 905973-89-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15520. | |
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