MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| CGP 12177 hydrochloride | CGP 12177 ((±)-CGP 12177) hydrochloride is a β-Adrenergic receptor (β-AR) ligand. CGP 12177 hydrochloride is a β3-AR (Ki = 88 nM) agonist with β1/β2-AR (Ki = 0.9 nM for β1; Ki = 4 nM for β2) antagonist action. CGP 12177 hydrochloride exhibits partial agonist properties for α1-AR in rat pulmonary artery. CGP 12177 hydrochloride regulates the expression of ucp and leptin genes in NMRI mice adipose tissues. CGP 12177 hydrochloride can be used for cardiovascular and metabolic disease research[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (±)-CGP 12177 hydrochloride. CAS No. 64208-32-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-101393A. |  |
| CGP 20712 A | CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CGP 20712 mesylate. CAS No. 105737-62-0. Pack Sizes: 5 mg. Product ID: HY-101355B. | |
| CGP 20712 dihydrochloride | CGP 20712 dihydrochloride is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 dihydrochloride exhibits ~10,000-fold selectivity over β2-adrenoceptors[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1216905-73-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-101355A. | |
| CGP35348 | CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only[1]. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 123690-79-9. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103530. | |
| CGP 36742 | CGP 36742 (SGS-742) is an orally active and selective antagonist of GABAB receptor (IC50 = 36 μM). CGP 36742 is a brain-penetrant compound and improves cognitive performances. CGP 36742 can be used for depression study[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SGS-742. CAS No. 123690-78-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121599. | |
| CGP37157 | CGP37157 is a potent, selective inhibitor of Na+/Ca2+ exchanger, inhibiting the Na+-induced Ca2+-release from guinea-pig heart mitochondria, with an IC50 of 0.8 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 75450-34-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15754. | |
| CGP-42112 | CGP-42112 (CGP-42112A) is a potent Angiotensin-II subtype 2 receptor(AT2 R) agonist[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CGP42112A. CAS No. 127060-75-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-12405. | |
| CGP52432 | CGP52432 is a GABAB receptor antagonist, with an IC50 of 85 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 139667-74-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103531. | |
| CGP-53353 | CGP-53353 (DAPH-7) is an potent PKC inhibitor with IC50s of 0.41 μM and 3.8 μM for PKCβII and PKCβI, respectively. CGP-53353 can inhibit glucose-induced cell proliferation and DNA synthesis in AoSMC and A10 cells. CGP-53353 can be used for researching atherosclerosis of diabetic patients[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DAPH-7. CAS No. 145915-60-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108600. | |
| CGP 53716 | CGP 53716 is a potent protein tyrosine kinase inhibitor. CGP 53716 has selective activity of platelet-derived growth factor (PDGF) receptor. CGP 53716 can be used in the study of disease induced by abnormal cell proliferation induced by PDGF receptor activation [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 152459-94-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101837. | |
| CGP 57380 | CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 with IC50 of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. Uses: Scientific research. Category: Signaling pathways. CAS No. 522629-08-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10520. | |
| CGP60474 | CGP60474, a highly potent anti-endotoxemic agent, is a potent cyclin-dependent kinase (CDK) inhibitor (IC50 values are 26, 3, 4, 216, 10, 200 and 13 nM for CDK1/B, CDK2/E, CDK2/A, CDK4/D, CDK5/p25, CDK7/H and CDK9/T, respectively). CGP60474 is a selective and ATP-competitive PKC inhibitor[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 164658-13-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11009. | |
| CGP-74514 | CGP-74514 (Compound 13) is a highly selective cyclin-dependent kinase 1 (CDK1) inhibitor (IC50=25 nM). CGP-74514 inhibits CDK1/cyclin B complex activity, arrests the cell cycle at G2/M phase and induces tumor cell apoptosis. CGP-74514 is promising for research of bladder cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 190653-73-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115565. | |
| CGP77675 | CGP77675 is an orally active and potent inhibitor of Src family kinases. CGP77675 inhibits phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50s of 5-20 and 40 nM, respectively), and also inhibits Src, EGFR, KDR, v-Abl, and Lck with IC50s of 5-20, 40, 20, 150, 1000, 310, and 290 nM, respectively. Anticancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 234772-64-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W062835. | |
| CGP78850 | CGP78850 is a potent and selective competitor of Grb2 SH2-phosphopeptide interactions. CGP78850 can be used for the research of cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 258326-83-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129800. | |
| CGS 15943 | CGS 15943 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. [1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 104615-18-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100678. | |
| CGS 21680 | CGS 21680 is a selective adenosine A2A receptor agonist, with a Ki of 27 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 120225-54-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-13201. | |
| CGS 21680 Hydrochloride | CGS 21680 Hydrochloride is a selective adenosine A2A receptor agonist with a Ki of 27 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 124431-80-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13201A. | |
| CH1055 | CH1055 is a near-infrared II (NIR-II) fluorescent dye that can be used as a fluorescent probe for in vivo imaging. CH1055 can be conjugated with antibodies or ligands for specific imaging (for example the tumor imaging)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1622250-38-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-D1464. | |
| CH-223191 | CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR).CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 301326-22-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-12684. | |
| CH 275 | CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst1) with a Ki of 52 nM[1]. CH 275 acts as a potent and selective sst1 agonist (IC50=30.9 nM) and also displays IC50 values of 345 nM, >1 μM, >10 μM, >10 μM for human sst3, sst4, sst2 and sst5, respectively[2]. CH 275 can be used for the research of alzheimers disease[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 174688-78-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1206. | |
| CH3OCO-D-CHA-Gly-Arg-pNA acetate | CH3OCO-D-CHA-Gly-Arg-pNA acetate is a chromogenic substrate for factor Xa[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 80895-10-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153829. | |
| Ch55 | Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC50 of 200 nM. Ch55 can be used for cancer research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 110368-33-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107397. | |
| CH6953755 | CH6953755 is a potent, orally active and selective YES1 kinase (a member of the SRC family) inhibitor with an IC50 of 1.8 nM. CH6953755 inhibits YES1 kinase, leading to antitumor activity against YES1 Gene -amplified cancers in vitro and in vivo[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2055918-71-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135299. | |
| CH7233163 | CH7233163 is a noncovalent ATP-competitive inhibitor for EGFR-Del19/T790M/C797S. CH7233163 can overcome Osimertinib (HY-15772)-Resistant EGFR-Del19/T790M/C797S mutation. CH7233163 blocks the EGFR phosphorylation in the Del19/T790M/C797S_NIH3T3 cells. CH7233163 has antitumor activities[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2923365-71-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137191. | |
| Chaetocin | Chaetocin is a specific inhibitor of the histone methyltransferase (HMT) SU(VAR)3-9 with an IC50 of 0.6 μM for SU(VAR)3-9. It also inhibits thioredoxin reductase (TrxR) with an IC50 of 4 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 28097-03-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N2019. | |
| Chaetoglobosin A | Chaetoglobosin A is a secondary metabolite and nematicide. Chaetoglobosin A is produced by Penicillium aquamarinium. Chaetoglobosin A targets Filamentous actin in cells, thereby inducing cell cycle arrest, and inhibiting membrane ruffle formation and cell migration. Chaetoglobosin A preferentially induces Apoptosis in chronic lymphocytic leukemia cells. Chaetoglobosin A induces dose- and time-dependent death in J2 larvae of the southern root-knot nematode (Meloidogyne incognita). Chaetoglobosin A can be used in studies related to root-knot nematode disease and chronic lymphocytic leukemia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 50335-03-0. Pack Sizes: 1 mg. Product ID: HY-N6744. | |
| CHAPS | CHAPS is a cholic acid-derived, sulfobetaine-type zwitterionic detergent and micelle-forming agent. CHAPS exhibits properties of weak cationic or nonionic surfactants in different solution systems, undergoes micellization, and forms small, loose hydrophilic aggregates that are temperature-dependent. CHAPS stabilizes mononucleosomes under different ionic strengths, reduces nucleosome sequence specificity, promotes sliding of histone cores along DNA, solubilizes Tamm-Horsfall protein to reduce its interference with urinary exosome isolation, and maintains vesicle structure and the activity of related proteins at the same time. CHAPS is used to recover native folded fusion proteins, enhance the binding capacity of GST fusion proteins, and restore GST enzyme activity. However, CHAPS cannot refold proteins denatured by urea, guanidine hydrochloride or heat, nor can it construct the structure of intrinsically disordered proteins. CHAPS is commonly used in research on the separation and purification of membrane proteins[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 75621-03-3. Pack Sizes: 10 mM * 1 mL in Water; 500 mg; 1 g; 5 g. Product ID: HY-15435. | |
| Charybdotoxin | Charybdotoxin, a 37-amino acid peptide, is a K+ channel blocker[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 95751-30-7. Pack Sizes: 100 μg; 500 μg; 1 mg; 5 mg. Product ID: HY-P0191. | |
| Chebulagic acid | Chebulagic acid is a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz, on angiogenesis. Chebulagic acid is a M2 serine to asparagine 31 mutation (S31N) inhibitor and influenza antiviral. Chebulagic acid also against SARS-CoV-2 viral replication with an EC50 of 9.76 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 23094-71-5. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg; 10 mg. Product ID: HY-N1996. | |
| Chebulic acid | Chebulic acid is a phenolic acid compound isolated from Terminalia chebula with strong antioxidant activity, which breaks protein cross-links induced by advanced glycation end products (AGEs) and inhibits the formation of AGEs. Chebulic acid is effective in controlling elevated metabolic parameters, oxidative stress, and liver damage, supporting its beneficial role in asthma, diabetes, and liver protection[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 23725-05-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N4170. | |
| Chebulinic acid | Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 18942-26-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N2033. | |
| Chelerythrine chloride | Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy. Uses: Scientific research. Category: Signaling pathways. CAS No. 3895-92-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12048. | |
| Chelidonine | Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L. Chelidonine causes G2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 476-32-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N2369. | |
| Chemerin15 | Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of Syk, ERK and Src kinases. Chemerin15 increases the expression of p-p38 mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1020407-90-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P6442. | |
| Chemotactic Domain of Elastin | Chemotactic Domain of Elastin is an elastin-derived peptide with chemotactic effects on certain tumor cells, such as M27 tumor cells. Chemotactic Domain of Elastin can be used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 92899-39-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4998. | |
| ChemR23-IN-1 | ChemR23-IN-1 (compound 2) is a ChemR23 inhibitor with IC50s of 38 nM and 100 nM for human and mouse ChemR23, respectively. ChemR23-IN-1 inhibits chemotaxis of CAL-1 triggered by Chemerin in vitro[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2378640-10-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-126536. | |
| Chenodeoxycholic Acid | Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CDCA. CAS No. 474-25-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g; 10 g; 25 g; 50 g; 100 g. Product ID: HY-76847. | |
| Chenodeoxycholic acid 24-acyl-β-D-glucuronide | Chenodeoxycholic acid 24-acyl-β-D-glucuronide is a metabolite of Chenodeoxycholic Acid (HY-76847)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 208038-27-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W585920. | |
| Chenodeoxycholic acid 3-sulfate disodium | Chenodeoxycholic acid 3-sulfate disodium is a bile acid. Chenodeoxycholic acid 3-sulfate disodium level corresponds closely with the extent of hepatic dysfunction[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 60237-34-5. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg. Product ID: HY-W779068. | |
| Chenodeoxycholic Acid-d4 | Chenodeoxycholic Acid-d4 is the deuterium labeled Chenodeoxycholic Acid. Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CDCA-d4. CAS No. 99102-69-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-76847S. | |
| Chetomin | Chetomin, an active component of Chaetomium globosum, is a heat shock protein 90/hypoxia-inducible factor 1 alpha (Hsp90/HIF1α) pathway inhibitor. Chetomin is a potent, nontoxic non-small cell lung cancer cancer stem cells (NSCLC CSC)-targeting molecule[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1403-36-7. Pack Sizes: 1 mg. Product ID: HY-107553. | |
| CHF5407 | CHF5407 is a selective, long-acting and competitive muscarinic M3 receptor antagonist. CHF5407 shows subnanomolar affinities for human muscarinic M1 (hM1), M2 (hM2) and M3 (hM3) receptors. CHF5407 shows a prolonged antibronchospastic activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1004312-94-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00302. | |
| Chiauranib | Chiauranib (CS2164) is an orally active multi-target inhibitor against tumor angiogenesis. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF-1R, with IC50 values ranging from 1-9 nM. Chiauranib has strongly anticancer effects[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ibcasertib; CS2164. CAS No. 1256349-48-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124526. | |
| Chicoric acid | Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cichoric acid; Dicaffeoyltartaric acid. CAS No. 6537-80-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0457. | |
| Chiglitazar | Chiglitazar (Carfloglitazar) is a PPARα/γ dual agonist, with EC50s of 1.2, 0.08, 1.7 μM for PPARα, PPARγ and PPARδ, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Carfloglitazar. CAS No. 743438-45-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106266. | |
| CHIKV-IN-2 | CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV), with excellent cellular antiviral activity (EC90=270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2361289-44-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132174. | |
| Chimaphilin | Chimaphilin is an IGF-1R inhibitor (IC50: 0.086 μM). Chimaphilin has antifungal, antioxidant and anticancer activities. Chimaphilin inhibits the growth of both drug-sensitive and drug-resistant osteosarcoma cell lines. Chimaphilin can induce cancer cell apoptosis. Chimaphilin is a main component of pyrola[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 482-70-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N6611. | |
| Chimonanthine | Chimonanthine is an alkaloid of Chimonanthus praecox, inhibits tyrosinase and tyrosine-related protein-1 mRNA expression, amd inhibits melanogenesis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (-)-Chimonanthine. CAS No. 5545-89-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N5118. | |
| CHIR-090 | CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase. It binds to E. coli LpxC with a Ki of 4.0 nM. CHIR-090 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. CAS No. 728865-23-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15460. | |
| CHIR-124 | CHIR-124 is a potent and selective Chk1 inhibitor with IC50 of 0.3 nM, and also potently targets PDGFR and FLT3 with IC50s of 6.6 nM and 5.8 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 405168-58-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13263. | |
| CHIR-98014 | CHIR-98014 is a potent, cell-permeable GSK-3 inhibitor with IC50s of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively; it shows less potent activities against cdc2 and erk2. Uses: Scientific research. Category: Signaling pathways. CAS No. 252935-94-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13076. | |
| Chitin, from crab carapace (powder),biomedical research grade | Chitin, from crab carapace (powder),biomedical research grade is a long-chain polymer of N-acetylglucosamine with β-(1-4) linkages. Chitin, from crab carapace (powder),biomedical research grade is found in the exoskeleton of crabs. Chitin, from crab carapace (powder),biomedical research grade inhibits the activation of NF-κB p65, alters the translocation of NF-κB p65 to the nucleus, and interacts with the cell wall of Candida species. Chitin, from crab carapace (powder),biomedical research grade exerts antifungal and anti-inflammatory effects. Chitin, from crab carapace (powder),biomedical research grade can be used in the research of gastric ulcer and candidiasis[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1398-61-4. Pack Sizes: 25 g; 50 g; 100 g. Product ID: HY-126389. | |
| Chitoheptaose heptahydrochloride | Chitoheptaose heptahydrochloride is a chitosan oligosaccharide with antioxidant, anti-inflammatory, antiapoptotic and cardioprotective activities. Chitoheptaose heptahydrochloride significantly enhances the growth and photosynthesis parameters of wheat seedlings[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 127171-89-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N7697D. | |
| Chitosanase | Chitosanase is a glycosyl hydrolase that catalyzes the endo hydrolysis of β-1,4-glycosidic bonds of partially acetylated chitosan to release chitosan oligosaccharides (COS). Chitosanases can convert high molecular weight chitosan into functional chitooligosaccharides with low molecular weight[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 51570-20-8. Pack Sizes: 10 U. Product ID: HY-P2859. | |
| Chitosan (≥90% deacetylated, Low viscosity,<200mPa.s) | Chitosan (Deacetylated chitin) (≥90% deacetylated, Low viscosity,<200mPa.s) is a polysaccharide obtained by deacetylating chitin, and exhibits antimicrobial activity against various bacteria and fungi[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Deacetylated chitin (≥90% deacetylated, Low viscosity,<200mPa.s); Poly(D-glucosamine) (≥90% deacetylated, Low viscosity,<200mPa.s). CAS No. 9012-76-4. Pack Sizes: 10 g; 25 g. Product ID: HY-B2144E. | |
| Chitosan (≥95% deacetylated,viscosity 100-200 mPa.s) | Chitosan (Deacetylated chitin) (≥95% deacetylated,viscosity 100-200 mPa.s) is a polysaccharide obtained by deacetylating chitin, and exhibits antimicrobial activity against various bacteria and fungi[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Deacetylated chitin (≥95% deacetylated,viscosity 100-200 mPa.s); Poly(D-glucosamine) (≥95% deacetylated,viscosity 100-200 mPa.s). CAS No. 9012-76-4. Pack Sizes: 25 g. Product ID: HY-B2144C. | |
| Chitosan hydrochloride (80%-90% deacetylated) | Chitosan hydrochloride 80%-90% deacetylated (Chitosan HCl 80%-90% deacetylated) is the deacetylated, hydrocholoride form of chitosan. Chitosan hydrochloride 80%-90% deacetylated is a polysaccharide obtained by deacetylating chitin, and exhibits antimicrobial activity against various bacteria and fungi. Chitosan hydrochloride 80%-90% deacetylated is utilized in agriculture, water treatment and pharmaceutical aspects[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Chitosan HCl (80%-90% deacetylated). CAS No. 70694-72-3. Pack Sizes: 25 g; 50 g; 100 g; 250 g; 500 g. Product ID: HY-B2144H. | |
| Chitosan (MW 150000) | Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Deacetylated chitin (MW 150000); Poly(D-glucosamine) (MW 150000). CAS No. 9012-76-4. Pack Sizes: 1 g; 5 g; 10 g. Product ID: HY-B2144A. | |
| Chitosan (MW 30000) | Chitosan (MW 30000) (Deacetylated chitin (MW 30000)) is a polycationic linear polysaccharide derived from chitin with the molecular weight of 30000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Deacetylated chitin (MW 30000); Poly(D-glucosamine) (MW 30000). CAS No. 9012-76-4. Pack Sizes: 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B2144B. | |
| Chitosan oligosaccharide | Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways. Uses: Scientific research. Category: Signaling pathways. Alternative Names: COS. CAS No. 148411-57-8. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-112108. | |
| Chk1-IN-5 | Chk1-IN-5 is a potent checkpoint kinase 1 (Chk1) inhibitor. Chk1-IN-5 inhibits Chk1 phosphorylation and inhibits tumor growth in colon cancer xenograft model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2120398-39-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131446. | |
| Chlophedianol hydrochloride | Chlophedianol (Clofedanol) hydrochloride is an orally active and potent antitussive agent. Chlophedianol hydrochloride can be used for the research of acute cough due to upper respiratory tract infections (URIs)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Clofedanol hydrochloride; Calmotusin hydrochloride; NSC 113595 hydrochloride. CAS No. 511-13-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-A0161A. | |
| Chlorambucil | Chlorambucil (CB-1348), an orally active antineoplastic agent, is a CNS-penetrant bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkins disease[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CB-1348; WR-139013. CAS No. 305-03-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-13593. | |
| Chloramphenicol | Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 56-75-7. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-B0239. | |
| Chloramphenicol 3-acetate | Chloramphenicol 3-acetate is the main intermediate in the biodegradation of CAP, formed by the acetylation of the 3-hydroxy group of CAP through chloramphenicol acetyltransferase, this is a common resistance mechanism that microbes have against chloramphenicol[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 10318-16-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-113897. | |
| Chloramphenicol-d5 | Chloramphenicol-d5 is the deuterium labeled Chloramphenicol. Chloramphenicol is a broad-spectrum antibiotic against bacterial infections[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 202480-68-0. Pack Sizes: 1 mg. Product ID: HY-B0239S. | |
| Chloramphenicol (Standard) | Chloramphenicol (Standard) is the analytical standard of Chloramphenicol. This product is intended for research and analytical applications. Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 56-75-7. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-B0239R. | |
| Chloramphenicol succinate sodium | Chloramphenicol succinate sodium is a prodrug of Chloramphenicol (HY-B0239), acting as a P2Y14R inhibitor with an IC50 of 1.585 nM. Chloramphenicol succinate sodium serves as a competitive substrate and inhibitor of succinate dehydrogenase (SDH), which may account for its toxicity. Chloramphenicol succinate sodium exerts a significant inhibitory effect on colitis. Chloramphenicol succinate sodium can be used in research related to myelosuppression, gray baby syndrome, aplastic anemia, bacterial meningitis and inflammatory bowel disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 982-57-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg. Product ID: HY-N7114A. | |
| Chlorantraniliprole | Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC50s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ~300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC50, 14 μM). Uses: Scientific research. Category: Induced disease models products. CAS No. 500008-45-7. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-112820. | |
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