MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Cl-4AS-1 | Cl-4AS-1, a potent steroidal androgen receptor (AR) agonist (IC50 = 12 nM), is also an inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 188589-66-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103245. |  |
| Cladosporin | Cladosporin is an antibiotic and an an antifungal metabolite that can be produced in good yield in the mycelium of Cladosporium cladosporioid. Cladosporin exhibits inhibitory activity against various dermatophytes, plant pathogens, and bacteria. Cladosporin also exhibits antimalarial activity through inhibition of cytoplasmic lysine-tRNA synthetase of Plasmodium (PfKrs1)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 35818-31-6. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-136767. | |
| Cladribine | Cladribine (2-Chloro-2-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 2-Chloro-2-deoxyadenosine; CldAdo; 2CdA. CAS No. 4291-63-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13599. | |
| Cl-amidine hydrochloride | Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor, with IC50 values of 0.8 μM, 6.2 μM and 5.9 μM for PAD1, PAD3, and PAD4, respectively. Cl-amidine hydrochloride induces apoptosis in cancer cells. Cl-amidine hydrochloride induces microRNA (miR)-16 (miRNA-16, microRNA-16) expression and causes cell cycle arrest. Cl-Amidine hydrochloride prevents histone 3 citrullination and neutrophil extracellular trap formation, and improves survival in a murine sepsis model[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1373232-26-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100574A. | |
| Clamikalant sodium | Clamikalant sodium (HMR 1098) is an ATP-sensitive potassium (KATP) channel blocker. Clamikalant sodium can be used for the research of arrhythmia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HMR 1098. CAS No. 261717-22-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15208. | |
| Clarithromycin | Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM[2]. Clarithromycin significantly inhibits the HERG potassium current[3].Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K[4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 81103-11-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg. Product ID: HY-17508. | |
| Clarithromycin-d3 | Clarithromycin-d3 is the deuterium labeled Clarithromycin (HY-17508)[1]. Clarithromycin has a broad spectrum of antimicrobial activity. Clarithromycin inhibits the CYP3A4-catalyzed triazolam alpha-hydroxylation with the IC50 (Ki) value of 56 (43) μM[3]. Clarithromycin significantly inhibits the HERG potassium current[4].Clarithromycin affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K[5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 959119-22-3. Pack Sizes: 5 mg. Product ID: HY-17508S1. | |
| Clascoterone | Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cortexolone 17 alpha-propionate; Cortexolone 17α-propionate; CB-03-01. CAS No. 19608-29-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-13331. | |
| Claseprubart | Claseprubart (DNTH103) is an inhibitor targeting C1s of the complement system and an inhibitor of the C1 component of the complement cascade. Claseprubart is in phase 2 clinical evaluation. Claseprubart has application potential in research related to multifocal motor neuropathy and generalized myasthenia gravis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: DNTH103. CAS No. 2922766-89-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P991127. | |
| clasto-Lactacystin β-lactone | Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Omuralide; β-Clastolactacystin. CAS No. 154226-60-5. Pack Sizes: 50 μg (2.34 mM * 100 μL in Methyl acetate). Product ID: HY-108549. | |
| Claturafenib | Claturafenib ( PF-07799933) is an orally active inhibitor of pan-mutant BRAF. Claturafenib inhibits pERK in cells (IC50 value of 1.6 nM in HT29 cells). Claturafenib has anticancer activity against BRAFG469A mutant NSCLC and BRAFK601E mutant melanoma[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-07799933; ARRY-440. CAS No. 2754408-94-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-159795. | |
| C-Laurdan | C-Laurdan is a modified Laurdan (HY-D0080) probe that imaging lipid rafts with environmentally sensitive fluorescence. C-Laurdan can be used in research of lipid arrangement and fluidity in biological membranes or artificial lipid membranes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 959839-06-6. Pack Sizes: 10 mM * 1 mL in DMSO; 2 mg; 5 mg. Product ID: HY-D1378. | |
| Clavulanate lithium | Clavulanate lithium is a potent β-lactamase inhibitor and acts as an antibiotic[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 61177-44-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-A0256B. | |
| Clavulanic acid | Clavulanic acid is a naturally occurring powerful bacterial β-lactamases inhibitor for research of infections caused by bacteria, including infections of the ears. Clavulanic acid is active against a wide spectrum of gram-positive and gram-negative bacterias[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 58001-44-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0256. | |
| Clazakizumab | Clazakizumab is a monoclonal antibody with high affinity and specificity for the IL-6 (interleukin-6) cytokine. Clazakizumab may be helpful in inhibiting the cytokine response to SARS-CoV-2 in COVID-19. Clazakizumab can be used for the research of psoriatic arthritis (PsA) and renal antibody-mediated rejection[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1236278-28-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99012. | |
| Clazosentan | Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction[1][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Ro 61-1790; VML 588; AXV-034343. CAS No. 180384-56-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17352. | |
| Clemastine | Clemastine (HS-592; Meclastine) is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HS-592; Meclastine. CAS No. 15686-51-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0298. | |
| Clemastine fumarate | Clemastine (HS-592; Meclastine) fumarate is an orally active, blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR), particularly the M1 and M4 subtypes. In addition to antihistamine effects, Clemastine fumarate exhibits multiple pharmacological activities, especially in promoting central nervous system remyelination, activating autophagy and pyroptosis, exerting anti-apoptotic and neuroprotective effects, and suppressing inflammation [1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: HS-592 fumarate; Meclastine fumarate. CAS No. 14976-57-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg. Product ID: HY-B0298A. | |
| Clematichinenoside AR | Clematichinenoside AR is a major active ingredient that could be extracted from the traditional Chinese herb Clematis chinensis and has potent pharmacological effects on various diseases, including atherosclerosis (AS)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 761425-93-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N4232. | |
| Clemizole hydrochloride | Clemizole hydrochloride is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. Clemizole hydrochloride is an inhibitor of TRPC5 channel. The IC50 of Clemizole hydrochloride for RNA binding by NS4B is 24 nM, whereas its EC50 for viral replication is 8 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1163-36-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-30234A. | |
| Clenbuterol hydrochloride | Clenbuterol (NAB-365) hydrochloride, a selective β2-adrenergic agonist, enhances skeletal muscle strength and hypertrophy. Clenbuterol hydrochloride induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NAB-365 hydrochloride. CAS No. 21898-19-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1614. | |
| Clesitamig | Clesitamig (ALPS-12) is a trispecific T cell engager with two CD3/CD137 dual-specific Fabs and one DLL3 Fab. Clesitamig engages CD3 and CD137 on T cells to activate and co-stimulate T cells, promoting their proliferation, survival, and antitumor activity. Clesitamig binds to DLL3 on tumor cells for tumor-specific recognition. Clesitamig can be used for the research of small cell lung cancer (SCLC)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ALPS-12; RG-6524; RO 7616789. CAS No. 2930861-48-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990981. | |
| Clesrovimab | Clesrovimab (MK1654) is a humanized IgG1 monoclonal antibody targeting the respiratory syncytial virus (RSV) protein F. Clesrovimab binds to pre-fusion and post-fusion forms of RSV-A fusion protein with high affinity, with corresponding KD values of 71 pM and 480 pM, respectively. Clesrovimab is applicable for the research of RSV infection[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK1654. CAS No. 2429913-18-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99804. | |
| Clevidipine | Clevidipine is a selective, short-acting L-type calcium channel antagonist with an IC50 of 7.1 nM. Clevidipine can competitively bind to calcium channels and exert rapid vasoselective vasodilation by blocking the influx of extracellular calcium ions, thereby reducing peripheral vascular resistance and effectively controlling acute severe hypertension. Clevidipine can also protect the myocardium from reperfusion injury by promoting the release of nitric oxide (NO). Clevidipine can be used in the research of acute hypertension, perioperative blood pressure management, and myocardial ischemia-reperfusion injury[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 167221-71-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17436. | |
| CLH304a | CLH304a (compound 14) is a specific and noncompetitive GABAB receptor negative allosteric modulator (NAM). CLH304a decreases GABA-induced IP3 production with an IC50 of 37.9 μM. CLH304a has no effect on other GPCR Class C members such as mGluR1, mGluR2, and mGluR5. CLH304a acts on the heptahelical domain of GB2 subunits and non-competitively inhibits the effect of agonists with inverse agonist properties. CLH304a inhibits Baclofen (HY-B0007)-induced ERK1/2 phosphorylation in HEK293 cells overexpressing GABAB receptor[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (E)-GABAB receptor antagonist 1. CAS No. 1611483-29-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-129636. | |
| Clifutinib | Clifutinib is an orally active and selective internal tandem duplication mutation of FMS-like tyrosine kinase 3 (FLT3-ITD) inhibitor with an IC50 value of 15.1 nM. Clifutinib exerts strong antiproliferative effects on FLT3-ITD acute myeloid leukemia (AML) cell lines (MV-4-11: IC50 = 1.5 nM; MOLM-13: IC50 = 1.4 nM). Clifutinib inhibits the activity of FLT3-ITD kinase and blocks the downstream RAS/MAPK, PI3K/AKT, and JAK/STAT5 signaling pathways of FLT3. Clifutinib induces apoptosis of acute myeloid leukemia (AML) cells with FLT3-ITD mutations. Clifutinib demonstrates significant antitumor efficacy in mice bearing MV-4-11 or MOLM-13 xenografts. Clifutinib is promising for research of relapsed/refractory FLT3-ITD-positive acute myeloid leukemia[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1862226-99-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-172581. | |
| Cligosiban | Cligosiban (PF-3274167) is an orally active, highly selective, and centrally permeable oxytocin receptor antagonist with good pharmacokinetics in rats and can inhibit physiological ejaculation in rodents[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-3274167. CAS No. 900510-03-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15023. | |
| Clindamycin | Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 18323-44-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1455. | |
| Clindamycin hydrochloride | Clindamycin (hydrochloride) is a semisynthetic lincosamide antibiotic, which inhibits protein synthesis by acting on the 50S ribosomal. Uses: Scientific research. Category: Signaling pathways. CAS No. 21462-39-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 1 g; 5 g. Product ID: HY-B0408A. | |
| Clindamycin phosphate | Clindamycin phosphate (Clindamycin 2-phosphate) is a broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin phosphate is the proagent of Clindamycin (HY-B1455) with no antimicrobial activity in vitro but can be rapidly converted in vivo to the active parent agent, Clindamycin, by phosphatase ester hydrolysis. Clindamycin phosphate can be used for researching acne and bacterial vaginosis[1][2][3]. Clindamycin phosphate has no cytotoxicity. Combined with platelet rich fibrin (PRF), PRF-Clindamycin phosphate enhances antimicrobial properties[4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Clindamycin 2-phosphate; U-28508. CAS No. 24729-96-2. Pack Sizes: 10 mM * 1 mL in Water; 100 mg; 500 mg; 1 g. Product ID: HY-B1064. | |
| Clioquinol | Clioquinol (Iodochlorhydroxyquin) is a topical antifungal agent with anticancer activity. Clioquinol acts as an oral antimicrobial agent for the research of diarrhea and skin infections. Antibiotic[1]. Clioquinol is a chelator that binds to Zn2+ and Cu2+ with a greater affinity than it binds to Ca2+ and Mg2+. Clioquinol freely crosses the blood-brain barrier. Clioquinol can be used for the study of Alzheimer's disease[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Iodochlorohydroxyquinoline. CAS No. 130-26-7. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-14603. | |
| CLIP (86-100) | CLIP (86-100) is amino acids 86 to 100 fragment of class II-associated invariant chain peptide (CLIP). CLIP is a small self-peptide and cleavage product of the invariant chain that resides in the HLA-II antigen binding groove and is believed to play a critical role in the assembly and transport of MHC class II alphabetaIi complexes through its interaction with the class II peptide-binding site[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 648881-58-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1826. | |
| Cliramitug | Cliramitug (NI-006; ALXN2220) is a monoclonal antibody that targets human transthyretin (TTR). Cliramitug binds to TTR and inhibits its amyloidogenic process, exerting amyloid formation-inhibiting activity. Cliramitug can be used in the research of transthyretin amyloidosis-related diseases, such as certain neurological and cardiovascular diseases[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NI-006; ALXN2220. CAS No. 2965214-50-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P991128. | |
| Clitocine | Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 105798-74-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-118341. | |
| Clitorin | Clitorin is an orally active flavonoid compound that can be isolated from Carica papaya. Clitorin is an inhibitor of EGFR (IC50: 89.58 nM) and aromatase (IC50: 77.41 nM). Clitorin has antioxidant and anti-tumor activities. In the DPPH and ABTS radical scavenging assays, Clitorin has IC50 values of 91.96 ppm and 250.45 ppm, respectively. In addition, Clitorin can regulate lipogenesis and fatty acid oxidation and can be used in the research of non-alcoholic fatty liver disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55804-74-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N7005. | |
| CLK1-IN-1 | CLK1-IN-1 is a potent and selective of Cdc2-like kinase 1 (CLK1) inhibitor, with an IC50 of 2 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 2123491-32-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103082. | |
| CLK1-IN-2 | CLK1-IN-2 is metabolically stable Clk1 inhibitor. CLK1-IN-2 has selectivity for Clk1 with an IC50 value of 1.7 nM. CLK1-IN-2 can be used for the research of tumour, Duchenne's muscular dystrophy and viral infections such as HIV-1 and influenza[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3029431-68-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152219. | |
| CLK1-IN-3 | CLK1-IN-3 (compound 10ad) is a potent and selective Clk1 inhibitor, with an IC50 of 5 nM and over 300-fold selectivity for Dyrk1A. CLK1-IN-3 also shows a relatively potent inhibition against Clk2 and Clk4, with IC50 values of 42 and 108 nM, respectively. CLK1-IN-3 potently induces autophagy in vitro. CLK1-IN-3 can be used for acute liver injury (ALI) research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2922550-28-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149262. | |
| CLK8 | CLK8 is a potent and specific CLOCK inhibitor that can disrupt the interaction between CLOCK and BMAL1 and interfere with nuclear translocation of CLOCK. CLK8 can be used for the research of disorders associated with dampened circadian rhythms[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 898920-65-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148765. | |
| CLK-IN-T3 | CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC50s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2109805-56-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115470. | |
| Cl-NQTrp | Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 185351-23-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138643. | |
| Clobetasol propionate | Clobetasol propionate is a potent and selective CYP3A5 inhibitor with an IC50 of 0.206 μM. Clobetasol propionate has no inhibiting on CYP3A4 or other major CYPs. Clobetasol propionate is a corticosteroid and has the potential for psoriasis and other dermatoses research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 25122-46-7. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg. Product ID: HY-13600. | |
| Clobutinol hydrochloride | Clobutinol hydrochloride is a compound that has anti-tussive effects. Clobutinol hydrochloride affects heart rate and blood pressure, it can be used for cough related research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1215-83-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148144A. | |
| Clodronate disodium tetrahydrate | Clodronate disodium tetrahydrate (Disodium clodronate tetrahydrate) is first-generation bisphosphonate, with anti-osteoporotic, anti-inflammatory and analgesic effects. Clodronate disodium tetrahydrate is a selective, potent, reversible and Cl- competitive vesicular nucleotide transporter (VNUT) inhibitor, with an IC50 of 15.6 nM. Clodronate disodium tetrahydrate inhibits vesicular ATP release from neurons and reduces chronic neuropathic and inflammatory pain[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Disodium clodronate tetrahydrate. CAS No. 88416-50-6. Pack Sizes: 10 mM * 1 mL in Water; 50 mg; 100 mg; 250 mg. Product ID: HY-107794. | |
| Clofarabine | Clofarabine, a nucleoside analogue for research of cancer, is a potent inhibitor of ribonucleotide reductase (IC50=65 nM) by binding to the allosteric site on the regulatory subunit[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 123318-82-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-A0005. | |
| Clofazimine | Clofazimine is an orally-active anti-mycobacterial agent with a wide range of anti-mycobacterial activity including leprosy and tuberculosis. Clofazimine exerts anti-inflammatory activities and anti-tumor activities by interfering DNA replication and inhibiting IL2 (IC50 = 1.10 ± 0.26 μM, Jurkat T) production. Clofazimine can be used in mycobacterial and cancer research[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2030-63-9. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B1046. | |
| Clofibrate | Clofibrate is an agonist of PPAR, with EC50s of 50 μM, ~500 μM for murine PPARα and PPARγ, and 55 μM, ~500 μM for human PPARα and PPARγ, respectively. Uses: Scientific research. Category: Signaling pathways. CAS No. 637-07-0. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0287. | |
| Clofilium tosylate | Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 92953-10-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg. Product ID: HY-33350. | |
| Clofoctol | Clofoctol is a bacteriostatic antibiotic. Clofoctol is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. Clofoctol is only functional against Gram-positive bacteria and can penetrate into human lung tissue. Clofoctol is also an inhibitor of prostate cancer. Clofoctol has antiviral potency[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 37693-01-9. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg. Product ID: HY-B1150. | |
| Clomiphene citrate | Clomiphene citrate (Clomifene citrate) is an orally active estrogen-receptor modulator. Clomiphene citrate has anti-cancer actixity, induces perturbations during meiotic maturation and cytogenetic abnormalities and ameliorates in managing psychiatric and cognitive impairment[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Clomifene citrate. CAS No. 50-41-9. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0463. | |
| Clomiphene-d5 hydrochloride | Clomifene (Clomifene; (Z/E)-Enclomiphene; (Z/E)-Enclomifene)-d5 hydrochloride is a deuterium labeled Clomifene hydrochloride (HY-A0287A). Clomiphene hydrochloride is an orally active ovulation-inducing agent. Clomiphene hydrochloride binds to hypothalamic estrogen receptors to elevate FSH levels, and exhibits antiestrogenic or estrogenic properties. Clomiphene hydrochloride can induce erturbations during meiotic maturation and cytogenetic abnormalities in mouse oocytes. Clomiphene hydrochloride ameliorates memory impairment in PCOS models. Clomiphene hydrochloride mobilizes cytosolic calcium and reduces viability in prostate cancer cells. Clomiphene hydrochloride can be used for the research of polycystic ovary syndrome (PCOS) and prostate cancer[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Clomifene-d5 hydrochloride; (Z/E)-Enclomiphene-d5 hydrochloride; (Z/E)-Enclomifene-d5 hydrochloride. CAS No. 1346606-66-3. Pack Sizes: 1 mg. Product ID: HY-A0287S. | |
| Clomipramine | Clomipramine (Chlorimipramine) is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Chlorimipramine; G-34586; NSC-169865. CAS No. 303-49-1. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0457A. | |
| Clomipramine hydrochloride | Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Chlorimipramine hydrochloride; G-34586 hydrochloride; NSC-169865 hydrochloride. CAS No. 17321-77-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B0457. | |
| Clonidine | Clonidine is an alpha 2-adrenergic agonist[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 4205-90-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-12721. | |
| Clonidine hydrochloride | Clonidine hydrochloride is an agonist of α2-adrenoceptor and potent antihypertensive agent. Uses: Scientific research. Category: Signaling pathways. CAS No. 4205-91-8. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0409A. | |
| Clonixin | Clonixin (SCH-10304) is an orally active non-steroidal anti-inflammatory agent in rodents[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SCH-10304. CAS No. 17737-65-4. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 500 mg; 1 g; 5 g. Product ID: HY-121235. | |
| Clopenthixol | Clopenthixol is a thiaquinoline compound with inhibitory effects similar to those of phenothiazine antipsychotics. Clopenthixol is an antagonist of D1 and D2 dopamine receptors. Clopenthixol is mainly used to suppress schizophrenia and other mental disorders[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 982-24-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0163A. | |
| Clopidogrel | Clopidogrel is an orally active platelet inhibitor that targets P2Y12 receptor. Clopidogrel is used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Clopidogrelum. CAS No. 113665-84-2. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg. Product ID: HY-15283. | |
| Clopidogrel carboxylic acid | Clopidogrel carboxylic acid (CLPM) is the inactive liver metabolite of anti platelet agent, Clopidogrel (HY-15283), in human serum[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CLPM; SR 26334. CAS No. 144457-28-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141749A. | |
| Clopidogrel hydrogen sulfate | Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively[1]. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation[2]. Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor[5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel hydrogen sulfate. CAS No. 120202-66-6. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g. Product ID: HY-17459. | |
| Clopidogrel impurity 1 | Clopidogrel impurity 1 is an impurity of Clopidogrel (HY-15283). Uses: Scientific research. Category: Signaling pathways. CAS No. 120202-71-3. Pack Sizes: 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W010935. | |
| (+)-Cloprostenol | (+)-Cloprostenol is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: D-Cloprostenol. CAS No. 54276-21-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-107381. | |
| Clopyralid (Standard) | Clopyralid (Standard) is the analytical standard of Clopyralid. This product is intended for research and analytical applications. Clopyralid is a toxic and biorefractory herbicide. Clopyralid can form ionic liquids with increased efficacy against weeds and reduced leaching from soils[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1702-17-6. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-W018749R. | |
| Clorgyline | Clorgyline (M&B 9302) is an orally active, blood-brain barrier permeable and selective monoamine oxidase A (MAO-A) inhibitor. Clorgyline's selective inhibition of MAO-A leads to reduced metabolism of neurotransmitters such as serotonin (5-hydroxytryptamine), which accumulates in the brain. Clorgyline can be used in the study of depression and neurodegenerative diseases[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: M&B 9302. CAS No. 17780-72-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14197. | |
| Clorgyline hydrochloride | Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research, structurally related to Pargyline (HY-A0091A). Clorgyline hydrochloride has little effect on the amounts of conjugated dopamine (DA) present in superfusate of slices from rat striatum. Clorgyline hydrochloride contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 17780-75-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-14197A. | |
| Closantel | Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 57808-65-8. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-17596. | |
| Clostripain | Clostripain (Clostridiopeptidase B) is a thiol protease isolated from Clostridium histolyticum. Clostripain exhibits proteolytic activity as well as amidase-esterase activity. The specificity of Clostripain is primarily restricted to arginine residues, but it also shows minor hydrolytic activity toward most lysine-containing substrates. Clostripain catalyzes the ammonolysis of Carbobenzoxyarginyl methyl ester to generate various dipeptides[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Clostridiopeptidase B. CAS No. 9028-00-6. Pack Sizes: 1 mg. Product ID: HY-P2895. | |
| Clothianidin | Clothianidin is a neonicotinoid insecticide. Clothianidin shows excellent long-term control effect in small doses against various insect pests such as Coleoptera, Thysanoptera, Lepidoptera, Diptera, Homoptera, Heteroptera, Orthoptera and Isoptera families. Clothianidin has various application methods and high safety for crops[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 210880-92-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-133167. | |
| Clothiapine | Clothiapine, an atypical antipsychotic agent, shares with clozapine its strong antiserotonergic properties[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2058-52-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-117083. | |
| Clotrimazole | Clotrimazole is an imidazole derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor. Clotrimazole has antibacterial activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 23593-75-1. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g. Product ID: HY-10882. | |
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