MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Coppersensor-3 | Coppersensor-3 (CS3) is a bright small-molecule fluorescent probe for selective Cu(I) detection. Coppersensor-3 is selective and sensitive enough to image labile copper pools in living cells at endogenous, basal levels. Coppersensor-3 can be used for the cell biology of copper research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1335151-56-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W753658. |  |
| Copper(?) sulfate | Copper(?) sulfate (Cupric sulfate) is an inorganic compound that is a source of copper ions. Copper(?) sulfate forms coordination compounds through the coordination of copper ions with ligands. Copper(?) sulfate can be used for various enzymatic studies and material synthesis[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cupric sulfate. CAS No. 7758-98-7. Pack Sizes: 25 g; 50 g; 100 g; 500 g; 1 k g. Product ID: HY-Y1878. | |
| Copper sulfate anhydrous, 99% | Anhydrous copper sulfate, 99% (Cupric sulfate anhydrous, 99%) is an orally administerable disinfectant. Anhydrous copper sulfate, 99% can be used as a biomaterial or organic compound related to life sciences research, and it can increase the Cu content in rat organs[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cupric sulfate anhydrous, 99%. CAS No. 7758-98-7. Pack Sizes: 10 mM * 1 mL in Water; 5 g; 10 g; 25 g. Product ID: HY-Y1878C. | |
| Copper sulfate pentahydrate, for cell culture, 98% | Copper sulfate pentahydrate, for cell culture, 98% is a biochemical reagent. Copper sulfate pentahydrate, for cell culture, 98% reduces the production of ROS and the expression levels of MyD88 as well as c-Rel genes. Copper sulfate pentahydrate, for cell culture, 98% decreases the activities of T-SOD, CAT, and GSH, increases the activities of caspase-3, caspase-8, and caspase-9. Copper sulfate pentahydrate, for cell culture, 98% is cytotoxic to various cells[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7758-99-8. Pack Sizes: 25 g. Product ID: HY-Y1881B. | |
| Copper tripeptide | Copper tripeptide (GHK-Cu) is a tripeptide. During wound healing, Copper tripeptide may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide is a natural modulator of multiple cllular pathways in skin regeneration[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: GHK-Cu. CAS No. 89030-95-5. Pack Sizes: 100 mg; 250 mg; 500 mg. Product ID: HY-P0063. | |
| Copper tripeptide-3 | Copper tripeptide-3 (AHK-Cu) is a bioactive peptide with promotion of hair growth effect. Copper tripeptide-3 increases dermal cell proliferation and viability while increasing the deposition of collagen to renew the extracellular matrix. Copper tripeptide-3 stimulates the elongation of human hair follicles and proliferation of dermal papilla cells[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AHK-Cu. CAS No. 767286-83-9. Pack Sizes: 50 mg; 100 mg; 250 mg. Product ID: HY-P5243. | |
| CO probe 1 | CO probe 1 (probe 2) is a highly efficient fluorescent CO probe (Ex=493 nm) with an allyl ether reaction site. In the presence of PdCl2, CO reduces Pd2+ to Pd0, triggering a Tsuji-Trost reaction that removes the allyl protecting group, releases fluorescein, and generates a significant fluorescence signal. CO probe 1 has high selectivity, rapid response (fluorescence enhancement of 150 times within 20 minutes), and low cytotoxicity, and can be used for real-time imaging of CO in living cells. CO probe 1 may be used to study pathological mechanisms involving CO signaling regulation, such as inflammation, vascular disease, or cancer[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1043865-37-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-D1244. | |
| Coproporphyrin I | Coproporphyrin I is an endogenous metabolite present in Urine and Blood that can be used for the research of Liver Disease and Porphyria[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 531-14-6. Pack Sizes: 1 mg. Product ID: HY-113318. | |
| Coproporphyrin I dihydrochloride | Coproporphyrin I dihydrochlorideIt is an organic compound belonging to the class of porphyrins. It is a derivative of heme, an iron-containing molecule found in hemoglobin and other proteins. Coproporphyrin I dihydrochlorideOften used as a biomarker in the assessment of certain liver and metabolic diseases, especially those related to bile synthesis and transport. It can also be used as a reference standard for analytical chemistry and pharmacological research. Uses: Scientific research. Category: Signaling pathways. CAS No. 69477-27-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-W073080. | |
| Coproporphyrin III | Coproporphyrin III (Zincphyrin) is a naturally occurring porphyrin derivative that is mainly found in urine[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Zincphyrin. CAS No. 14643-66-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-101398. | |
| Coproporphyrin III dihydrochloride | Coproporphyrin III dihydrochloride is a bioactive molecule excreted by nostril- and skin-associated Propionibacterium species that induces aggregation of Staphylococcus aureus (conditions: during early stationary phase growth, low pH: 4-6). Coproporphyrin III dihydrochloride also induces plasma-independent biofilm formation on abiotic surfaces by Staphylococcus aureus. Coproporphyrin III dihydrochloride may be an important mediator of S. aureus accumulation and/or biofilm formation in the nostrils or other sites where Propionibacterium and S. aureus inhabit[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Zincphyrin dihydrochloride. CAS No. 68938-73-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-W412175. | |
| Coprostanol | Coprostanol (5β-Cholestan-3β-ol) is a fecal sterol formed by microbial reduction of cholesterol in the intestines of man and higher animals. Coprostanol can be used as an indicator sterol of fecal pollution. Coprostanol has been recognized as a good indicator of pollution of water resources by sewage discharges. Coprostanol can serve as a potential biological indicator for cerebral chondrodystrophy (CTX)[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5β-Cholestan-3β-ol. CAS No. 360-68-9. Pack Sizes: 10 mM * 1 mL in Ethanol; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118103. | |
| Coprostanone | Coprostanone (5β-cholestan-3-one) is an oxysterol and active metabolite of Cholesterol (HY-N0322). Coprostanone induces apoptosis in primary dog gallbladder epithelial cells. Coprostanone is promising for research of colon cancers or adenomatous polyps[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 5β-Cholestan-3-one. CAS No. 601-53-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-W588187. | |
| Coralyne chloride | Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage[2]. Coralyne chloride can be used for preparing?coralyne derivatives?as DNA binding fluorescent probes[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 38989-38-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118581. | |
| Coramitug | Coramitug is an anti-TTR human IgG1 κ monoclonal antibody[1]. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001). Uses: Scientific research. Category: Signaling pathways. CAS No. 2626841-92-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990734. | |
| Cordycepin | Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner[1]. Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3'-Deoxyadenosine. CAS No. 73-03-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0262. | |
| Cordycepin (Standard) | Cordycepin (Standard) is the analytical standard of Cordycepin. This product is intended for research and analytical applications. Cordycepin (3'-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner[1]. Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 3'-Deoxyadenosine (Standard). CAS No. 73-03-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0262R. | |
| Corilagin | Corilagin, a gallotannin, has anti-tumor, anti-inflammatory and hepatoprotective activities. Corilagin inhibits activity of reverse transcriptase of RNA tumor viruses. Corilagin also inhibits the growth of Staphylococcus aureus with a MIC of 25 μg/mL. Corilagin shows anti-tumor activity on hepatocellular carcinoma and ovarian cancer model. Corilagin shows low toxicity to normal cells and tissues[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NP-004255. CAS No. 23094-69-1. Pack Sizes: 5 mg; 10 mg; 20 mg. Product ID: HY-N0462. | |
| Corin | Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1. Uses: Scientific research. Category: Signaling pathways. CAS No. 1808113-09-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111048. | |
| CORM-3 | CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 475473-26-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100581. | |
| CORM-401 | CORM-401 is an oxidant-sensitive CO-releasing molecule. CORM-401 induces NO increase in the regulation of endothelial calcium signalling. CORM-401 reduces TNF-α/CHX and H2O2-induced ROS production. CORM-401 uncouples mitochondrial respiration and inhibits glycolysis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1001015-18-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-109804. | |
| CORM-A1 | CORM-A1 (Sodium boranocarbonate) is a water-soluble carbon monoxide (CO) releasing molecule that facilitates the investigation of CO's impact on cellular systems. As CO is generated from heme degradation by the enzyme heme oxygenase, it serves as a crucial gaseous signaling mediator in mammalian cells. CORM-A1 not only exhibits anti-oxidant and anti-inflammatory properties but also regulates CO release in a manner dependent on pH and temperature, promoting mild vasorelaxation and hypotension. Furthermore, CORM-A1 has been shown to provide cytoprotection in primary cultures of astrocytes under oxidative stress while also enhancing autophagy due to its boron-containing composition. Uses: Scientific research. Category: Biochemical assay reagents. Alternative Names: Sodium boranocarbonate. CAS No. 17363-08-5. Pack Sizes: 10 mM * 1 mL in Water; 10 mg. Product ID: HY-W782399. | |
| Corn oil | Corn oil, extracted from the germ of corn, can be used as a carrier for agent molecules. Uses: Scientific research. Category: Signaling pathways. CAS No. 8001-30-7. Pack Sizes: 50 mL; 100 mL; 500 mL; 1 L. Product ID: HY-Y1888. | |
| Corn steep liquor | Corn steep liquor, a food industrial by-product, is a nutritional additive in the liquid culture medium of fungus. Corn steep liquor can increase the production of fairy chemicals and mycelia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 66071-94-1. Pack Sizes: 100 g; 250 g; 500 g; 1 k g. Product ID: HY-W133982. | |
| Cornuside | Cornuside is an iridoid glycoside with anti-allergic, anti-inflammatory, and neuroprotective activities. Cornuside exerts anti-allergic activity by downregulating the p38 MAPK, JNK, and NF-κB signaling pathways, and inhibits IgE-mediated histamine release from mast cells. Cornuside improves cognitive impairment in mice by inhibiting BACE1 activity (IC50 = 55.84 μg/mL) and enhancing ChAT activity. Cornuside inhibits LPS (HY-D1056)-induced inflammatory mediators, including iNOS, COX-2, PGE2, TNF-α, IL-6, and IL-1β, by suppressing NF-κB activation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 131189-57-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0631. | |
| Coronarin E | Coronarin E is a compound isolated from the rhizome of Hedychium coronarium (Zingiberaceae)[1]. Uses: Scientific research. Category: Natural products. Alternative Names: (+)-Coronarin E. CAS No. 117591-81-8. Pack Sizes: 1 mg. Product ID: HY-N3633. | |
| Coronastat | Coronastat is a potent inhibitor of the SARS-CoV-2 3CL protease. The SARS-CoV-2 3CL protease is a critical agent target for small molecule COVID-19, given its likely agentgability and essentiality in the viral maturation and replication cycle[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NK01-63. CAS No. 2922281-15-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-147020. | |
| Coronatine | Coronatine is a plant growth regulator that mimicks the jasmonic acid-isoleucine conjugate (JA-Ile), targets the jasmonic acid receptor COI1, activates the jasmonic acid signaling pathway, thereby inhibiting salicylic acid (SA)-dependent defense responses. Coronatine antagonizes the stomatal closure, induces plant cell necrosis and chlorosis, interfers with plant hormone balance, thereby promoting pathogen infection[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 62251-96-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg. Product ID: HY-N11420. | |
| Corosolic acid | Corosolic acid (Colosolic acid) isolated from the fruit of Cratoegus pinnatifida var. psilosa, was reported to have anticancer activity. Corosolic acid induces cancer cell apoptosis[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Colosolic acid. CAS No. 4547-24-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0280. | |
| Cort108297 | Cort108297 is a specific glucocorticoid receptor (GR) antagonist. Cort108297 has a high affinity for GRs with a Ki of 0.45 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 1018679-79-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15710. | |
| Corticosterone | Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 17-Deoxycortisol; 11β,21-Dihydroxyprogesterone; Kendall's compound B. CAS No. 50-22-6. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B1618. | |
| Corticosterone-d8 | Corticosterone-d8 is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. Uses: Scientific research. Category: Signaling pathways. CAS No. 1271728-07-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-B1618S. | |
| Corticosterone (Standard) | Corticosterone (Standard) is the analytical standard of Corticosterone. This product is intended for research and analytical applications. Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 17-Deoxycortisol(Standard); 11β,21-Dihydroxyprogesterone(Standard); Kendall's compound B (Standard). CAS No. 50-22-6. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1618R. | |
| Corticotropin-releasing factor (human) | Corticotropin-releasing factor human (Human CRF) stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Human CRF; Human corticotropin-releasing factor. CAS No. 86784-80-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0086. | |
| Cortisol sulfate sodium | Cortisol sulfate sodium (Cortisol 21-sulfate) is a metabolite of Cortisol (HY-N0583). Cortisol sulfate sodium is a specific ligand for intracellular transcortin[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cortisol 21-sulfate sodium. CAS No. 1852-36-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N8460A. | |
| Cortisone | Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 17-Hydroxy-11-dehydrocorticosterone; Kendall's compound E. CAS No. 53-06-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-17461. | |
| Cortisone (Standard) | Cortisone (Standard) is the analytical standard of Cortisone. This product is intended for research and analytical applications. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 17-Hydroxy-11-dehydrocorticosterone(Standard); Kendall's compound E (Standard). CAS No. 53-06-5. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-17461R. | |
| Cortistatin-14 | Cortistatin-14 is a neuropeptide that shares structural similarities with somatostatin, working by binding to somatostatin receptors (sst1-sst5). Cortistatin-14 (TFA) has anticonvulsant, neuroprotective effects, and significant anti-inflammatory properties[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 186901-48-4. Pack Sizes: 500 μg; 1 mg; 5 mg; 10 mg. Product ID: HY-P1932. | |
| Cortistatin 14 (mouse, rat) | Cortistatin 14, mouse, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CST-14 (mouse, rat). CAS No. 193829-96-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1212. | |
| Cortistatin-17 (human) | Cortistatin-17 (human) is a somatostatin neuropeptide with potential for studying diseases such as cancer, inflammation, autoimmunity, fibrosis, and pain[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 189450-19-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5011. | |
| Cortistatin-8 | Cortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PCFWKTCK. CAS No. 485803-62-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1139. | |
| Cortodoxone | Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation[1][2]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: 11-Deoxycortisol; cortexolone; Reichstein's substance S. CAS No. 152-58-9. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-77839. | |
| Corydine | Corydine is a HIV-1 reverse transcriptase inhibitor and μ-opioid receptor (MOR) agonist, with an IC50 of 356.7 μg/mL against HIV-1 reverse transcriptase, an EC50 of 0.51 μM for MOR, and a Ki of 2.82 μM for MOR. Corydine produces antinociceptive effects by inhibiting acetic acid-induced writhing behavior in a MOR-dependent manner. Corydine inhibits the proliferation of cancer cells, mitogen-stimulated lymphocytes and IL-2-dependent cells. Corydine can be used in studies related to human immunodeficiency virus infection, visceral pain, leukemia, melanoma, bladder cancer and colon adenocarcinoma[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 476-69-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N2571. | |
| Corypalmine | Corypalmine is an alkaloid identified in the dried tubers of Corydalis Decumbens Pers, with an oral bioavailability of 4.6% in mice. Corypalmine exhibits poor gastrointestinal absorption properties, which correlate with its high hydrophilicity and low permeability[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 27313-86-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0654. | |
| Cosalane | Cosalane (NSC 658586) is a CCR7 (IC50 = 2.43 μM) and CXCR2 antagonist (IC50 = 0.66 μM). Cosalane is an inhibitor of HIV replication with a wide range of activity against HIV-1 isolates, HIV-2, Rauscher murine leukemia virus, HSV-1, HSV-2 and human cytomegalovirus. Cosalane inhibits both attachment of gp120 to CD4. Cosalane inhibits human and murine CCR7 in response to both CCL19 and CCL21 agonists. Cosalane can be studied in research for HIV or attenuating acute graft-versus-host disease (aGVHD) in allogeneic hematopoietic stem cell transplantation (HSCT)[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC 658586. CAS No. 154212-56-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-120427. | |
| Cosibelimab | Cosibelimab (CK-301) is a high-affinity, fully human PD-L1-blocking monoclonal antibody that binds PD-L1 and blocks its interaction with PD-1. Cosibelimab exhibits antitumor efficacy[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CK-301; TG-1501. CAS No. 2216751-26-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99833. | |
| Costunolide | Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (+)-Costunolide; Costus lactone. CAS No. 553-21-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0036. | |
| Cotadutide | Cotadutide (MEDI0382) is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide can be used in the research of obesity and type 2 diabetes (T2D)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MEDI0382. CAS No. 1686108-82-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2231. | |
| COTI-2 | COTI-2, an anti-cancer agent with low toxicity, is an orally available third generation activator of p53 mutant forms. COTI-2 acts both by reactivating mutant p53 and inhibiting the PI3K/AKT/mTOR pathway. COTI-2 induces apoptosis in multiple human tumor cell lines. COTI-2 exhibits antitumor activity in HNSCC through p53-dependent and -independent mechanisms. COTI-2 converts mutant p53 to wild-type conformation[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1039455-84-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19896. | |
| Cot inhibitor-2 | Cot inhibitor-2 is a potent, selective and orally active cot (Tpl2/MAP3K8) inhibitor with an IC50 of 1.6 nM. Cot inhibitor-2 inhibts TNF-α production in LPS-stimulated human whole blood with an IC50 of 0.3 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 915363-56-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-32018. | |
| Cotinine | Cotinine ((-)-Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S)-(-)-Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-)-Cotinine) is used in research related to cardiovascular and inflammatory diseases[1][2][3][4][5]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: (-)-Cotinine; (S)-Cotinine; NIH-10498. CAS No. 486-56-6. Pack Sizes: 10 mM * 1 mL in DMSO; 25 mg; 50 mg; 100 mg. Product ID: HY-B1178. | |
| Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:19) | Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:19), an antibacterial agent, is a Trimethoprim (HY-B0510) and Sulfamethoxazole (HY-B0322) mixture. The ratio of Trimethoprim to Sulfamethoxazole in the combination mixture is 1?:?19[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 8064-90-2. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 500 mg; 1 g. Product ID: HY-141619A. | |
| Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:5) | Cotrimoxazole (Trimethoprim/sulfamethoxazole 1:5), an antibacterial agent, is a Trimethoprim (HY-B0510) and Sulfamethoxazole (HY-B0322) mixture. The ratio of Trimethoprim to Sulfamethoxazole in the combination mixture is 1?:?5[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 8064-90-2. Pack Sizes: 10 mM * 1 mL in DMSO; 250 mg; 500 mg; 1 g. Product ID: HY-141619. | |
| Cottonseed oil | Cottonseed oil is an edible oil extracted from the seeds of cotton (Gossypium hirsutum). Its fatty acid composition includes 26-35% saturated fatty acids, 42-52% polyunsaturated fatty acids, and 18-24% monounsaturated fatty acids. Cottonseed oil is regarded as an Insecticide, as it is used to protect the trunks of apple trees from damage by the apple clearwing moth. Cottonseed oil possesses anti-inflammatory and cardioprotective properties. It also has extensive applications in many fields such as biofuels, animal husbandry, cosmetics, agriculture, and chemical industry[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 8001-29-4. Pack Sizes: 100 mL; 500 mL. Product ID: HY-Y1887. | |
| Coumarin | Coumarin is a potent and orally active anti-inflammatory agent. Coumarin shows an antinociceptive effect. Coumarin shows antibacterial, antifungal and anticancer activity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 91-64-5. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-N0709. | |
| Coumarin 6 | Coumarin 6, a fluorescent dye, is used as a fluorescent probe in a microparticle drug delivery system to conduct in vivo tracking, cell uptake, and transport mechanism studies of drug delivery systems (λexc=450 nm, λem=505 nm)[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 38215-36-0. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 50 mg; 100 mg. Product ID: HY-N7131. | |
| Coumarin boronic acid | Coumarin boronic acid is a fluorescent probe. The excitation and emission wavelengths of coumarin boronic acid are set to 360 nm and 430 nm, respectively. Coumarin boronic acid can be used to monitor the formation of amino acid and protein hydroxyl peroxides in real time, which is beneficial for understanding the mechanisms of oxidative stress and protein post-translational modification[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1357078-03-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W116606. | |
| Coumarin-C2-exo-BCN | Coumarin-C2-exoBCN is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-exoBCN contains the lyophilic bidentate macrocyclic ligand exo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, exo-BCN can react with molecules containing azide groups to generate stable triazoles under catalyst-free conditions. Uses: Scientific research. Category: Signaling pathways. CAS No. 2488174-17-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156305. | |
| Coumarin hydrazine | Coumarin hydrazine is a fluorescent chemical probe (λex=420-450/λem=468nm) to label cellular protein- and lipid-bound carbonyls[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 113707-87-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124197. | |
| Coumberol | Coumberol is a fluorescent substrate of AKR1C3 protein. Coumberol can be used for the research of AKR1C3[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 878019-53-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1342. | |
| Coumberone | Coumberone is a metabolic fluorogenic probe, and isoform-selective substrate for all AKR1C isoforms. Coumberone can be reduced by all four members of the AKR1C family to its fluorescent alcohol coumberol. Coumberone can be used for the research of AKR1C[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 878019-47-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1341. | |
| Coumermycin A1 | Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria. Coumermycin A1 shows anti-orthopoxvirus activity. Uses: Scientific research. Category: Signaling pathways. CAS No. 4434-5-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N7452. | |
| Coumestrol | Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM. Uses: Scientific research. Category: Signaling pathways. CAS No. 479-13-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2335. | |
| cp028 | cp028 is a potent pre-mRNA splicing inhibitor. cp028 inhibits splicing in HeLa nuclear extract with an IC50 value of 54 μM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 347397-83-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136951. | |
| CP-10 | CP-10 is a PROTAC connected by ligands for Cereblon and CDK, with highly selective, specific, and remarkable CDK6 degradation (DC50=2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2366268-80-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-125835. | |
| CP-100356 hydrochloride | CP-100356 hydrochloride is an orally active dual MDR1 (P-gp)/BCRP inhibitor, with an IC50s of 0.5 and 1.5 μM for inhibiting MDR1-mediated Calcein-AM transport and BCRP-mediated Prazosin transport, respectively. CP-100356 hydrochloride is also a weak inhibitor of OATP1B1 (IC50=?66 μM). CP-100356 hydrochloride is devoid of inhibition against MRP2 and major human P450 enzymes (IC50>15 μM)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 142715-48-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108347. | |
| CP-105696 | CP-105696 is a potent and selective Leukotriene B4 Receptor antagonist, with an IC50 of 8.42 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pfizer 105696. CAS No. 158081-99-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19193. | |
| CP 154526 hydrochloride | CP 154526 hydrochloride is a potent, brain-penetrant and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki of 2.7 nM. CP 154526 hydrochloride shows selective for CRF1 over CRF2 (Ki = >10 μM). CP 154526 hydrochloride has anxiolytic activities[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 257639-98-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12129. | |
| CP21R7 | CP21R7 is potent GSK-3β inhibitor, with an IC50 of 1.8 nM; CP21R7 also shows inhibitory activitiy against PKCα, with an IC50 of 1900 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CP21. CAS No. 125314-13-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100207. | |
| CP-24879 hydrochloride | CP-24879 (hydrochloride) is a potent, selective and combined delta5D/delta6D inhibitor. CP-24879 (hydrochloride) can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 (hydrochloride) exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes, and can be used for non-alcoholic steatohepatitis research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 10141-51-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115319. | |
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