MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Creatine Kinase (CPK/CK), Bovine Heart | Creatine Kinase (CPK/CK), Bovine Heart (CK) is a creatine kinase derived from bovine heart. Creatine Kinase (CPK/CK), Bovine Heart catalyzes the reversible phosphate transfer reaction between phosphocreatine and ADP, and is widely used in myocardial energy metabolism research and quality control of clinical biochemical tests[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CK, CPK, Creatine Phosphokinase. CAS No. 9001-15-4. Pack Sizes: 1 KU; 5 KU; 10 KU. Product ID: HY-P2799A. |  |
| Creatine phosphokinase, Rabbit muscle | Creatine phosphokinase, Rabbit muscle (CPK) catalyzes the reversible reaction of creatine and ATP to form phosphocreatine and ADP. Creatine phosphokinase is a key enzyme for maintaining a constant ATP/ADP ratio during rapid energy turnover[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CPK. CAS No. 9001-15-4. Pack Sizes: 1 KU. Product ID: HY-P2799. | |
| Creatine (Standard) | Creatine (Standard) is the analytical standard of Creatine. This product is intended for research and analytical applications. Creatine, an endogenous amino acid derivative, plays an important role in cellular energy, especially in muscle and brain. Uses: Scientific research. Category: Signaling pathways. CAS No. 57-00-1. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-W010388R. | |
| Creatininase, Microorganism | Creatininase, Microorganism (Creatinine amidohydrolase; CAH), namely creatinine amidohydrolase, from Pseudomonas putida, is a homohexameric enzyme commonly used in biochemical research. Creatininase acts on carbon-nitrogen bonds other than peptide bonds, and can catalyze the hydrolysis of creatinine to creatine, which can then be metabolized by creatinase to urea and sarcosine[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Creatinine amidohydrolase; CAH. CAS No. 9025-13-2. Pack Sizes: 1 KU. Product ID: HY-P2838. | |
| Creatinine | Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC13123. CAS No. 60-27-5. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0504. | |
| Creatinine-d3 | Creatinine-d3 is a deuterium labeled Creatinine. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: NSC13123-d3. CAS No. 143827-20-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0504S. | |
| Creatinine deiminase | Creatinine deiminase is a hydrolytic enzyme. Creatinine deiminase plays a crucial role in the conversion of the metabolic waste creatinine into creatine. Creatinine deiminase is a creatine bioanalytical tool. Creatinine deiminase can be used to construct a novel creatinine-sensitive biosensor when adsorbed on a silicate-modified pH-sensitive field-effect transistor (pH-FET)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 37289-15-9. Pack Sizes: 250 U; 500 U; 1 KU. Product ID: HY-P2815. | |
| Crebanine | Crebanine is an isoquinoline-like alkaloid that can be derived from Stephania. Crebanine is an antagonist of the α7-nAChR with an IC50 of 19.1 μM. Crebanine suppresses the proliferation, migration, and invasion of cancer cells, triggers reactive oxygen species (ROS) burst, and promotes apoptosis. Crebanine inhibits the AKT/FoxO3a, NF-κB and MAPK signaling pathways. Crebanine attenuates NOX2 hyperactivation, exhibits antioxidant properties by reducing reactive oxygen species and peroxidation in microglia cells. Crebanine inhibits voltage-dependent Na+ current in guinea-pig ventricular myocytes. Crebanine has high inhibitory activity against gram-positive animal pathogenic bacteria. Crebanine ameliorates ischemia-reperfusion brain damage in middle cerebral artery occlusion and reperfusion (MCAO/R) rats. Crebanine significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice. Crebanine can be used for the study of hepatocellular carcinoma (HCC), cerebral ischemia and Alzheimer's disease[1][2][3][4][5][6]. Uses: Scientific research. Category: Signaling pathways. CAS No. 25127-29-1. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 20 mg; 50 mg; 100 mg. Product ID: HY-N2255. | |
| Crebankitug | HY-P990911 is an IL7R-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096)[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ZB-168. CAS No. 2893793-17-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990911. | |
| Crefmirlimab | Crefmirlimab (IAB22M2C; ImaginAb) is a humanized CD8-specific single-domain antibody. Conjugation of Crefmirlimab with radioisotopes (e.g., 89Zr) enables tumor immune infiltration assessment, autoimmune disease detection, and immunotherapy response monitoring. Crefmirlimab is applicable for cancer research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IAB22M2C; ImaginAb. CAS No. 2611099-93-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99834. | |
| Cremophor EL-36 | Cremophor EL-36 is a non-ionic surfactant, mainly used as a solubilizing carrier for poorly soluble Paclitaxel (HY-B0015). For example, Cremophor EL-36 can enhance the intracellular influx of Etoposide (HY-13629) without affecting drug efflux, and can dose-dependently increase the accumulation of VP-16 in lung adenocarcinoma cells (such as PC-14 and A549), significantly enhancing its cytotoxic effect[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyoxyethylene(36) Castor Oil; PEG-36 Castor Oil. CAS No. 61791-12-6. Pack Sizes: 50 g; 100 g. Product ID: HY-401424. | |
| Cremophor EL-40 | Cremophor EL-40, a polyoxyethylene castor oil derivative, is a nonionic surfactant. Cremophor EL-40 is widely employed to improve dissolution and delivery of agents[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Polyoxyethylene(40) Castor Oil; PEG-40 Castor Oil. CAS No. 61791-12-6. Pack Sizes: 100 mL. Product ID: HY-Y1890. | |
| Crenezumab | Crenezumab (MABT 5102A; RG 7412) is a fully humanized anti-Aβ monoclonal antibody that binds multiple forms of Aβ, such as soluble, oligomeric and fibrillar, for use in Alzheimer's disease research[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MABT 5102A; RG 7412. CAS No. 1095207-05-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99835. | |
| Crenigacestat | Crenigacestat (LY3039478) is an orally active Notch and γ-secretase inhibitor, with an IC50 of 1 nM in most of the tumor cell lines tested[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: LY3039478. CAS No. 1421438-81-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12449. | |
| Crenolanib | Crenolanib is a potent and selective inhibitor of wild-type and mutant isoforms of the class III receptor tyrosine kinases FLT3 and PDGFRα/β with Kds of 0.74 nM and 2.1 nM/3.2 nM, respectively. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CP-868596. CAS No. 670220-88-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13223. | |
| cRGDfK-thioacetyl ester | cRGDfK-thioacetyl ester is a bioactive polypeptide molecule. cRGDfK peptide has a selective affinity for integrins. cRGDfK peptide can modify NIR fluorescent probes for cancer targeting imaging[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 393781-65-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5287. | |
| Crinecerfont hydrochloride | Crinecerfont (SSR-125543) hydrochloride is an orally effective corticotropin-releasing factor receptor type-1 (CRF1 receptor) antagonist. Crinecerfont hydrochloride blocks CRF1 receptor signaling to reduce adrenocorticotropic hormone secretion. Crinecerfont hydrochloride improves hypothalamic-pituitary-adrenal axis negative feedback sensitivity in chronically stressed mice. Crinecerfont hydrochloride can be used for the research of chronic stress conditions and classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency[1][2]. Crinecerfont hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SSR-125543 hydrochloride. CAS No. 321839-75-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106203A. | |
| Crisaborole | Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC50 of 0.49 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AN-2728; PF-06930164. CAS No. 906673-24-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10978. | |
| Crisaborole (Standard) | Crisaborole (Standard) is the analytical standard of Crisaborole. This product is intended for research and analytical applications. Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC50 of 0.49 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AN-2728 (Standard); PF-06930164 (Standard). CAS No. 906673-24-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10978R. | |
| Crisdesalazine | Crisdesalazine (AAD-2004) is a microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Crisdesalazine acts as a potent free radical scavenger that directly neutralizes reactive oxygen species (ROS) including hydrogen peroxide, exerting neuroprotective effects against apoptosis and axonal damage. Crisdesalazine inhibits PGE2 production, mediates inflammatory responses, and promotes the conversion of macrophages from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype. Crisdesalazine is applicable to neuroprotection research in multiple sclerosis and spinal cord injury[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: AAD-2004. CAS No. 927685-43-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-105005. | |
| Crizanlizumab | Crizanlizumab is an anti-P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: hSel001; SEG101. CAS No. 1690318-25-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9987. | |
| Crizotinib | Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-02341066. CAS No. 877399-52-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50878. | |
| Crizotinib-d5 | Crizotinib-d5 is the deuterium labeled Crizotinib. Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-02341066-d5. CAS No. 1395950-84-1. Pack Sizes: 1 mg. Product ID: HY-50878S. | |
| Crizotinib hydrochloride | Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: PF-02341066 hydrochloride. CAS No. 1415560-69-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50878A. | |
| Crocetin | Crocetin (Transcrocetin) is an aglycone of crocin. Crocetin is an orally active and brain-penetrant. Crocetin shows strong NMDA receptor affinity and channel opening activity. Crocetin can downregulate the proinflammatory cytokines and COX-2 exoression. Crocetin can inhibit apoptosis and activation of MAPK. Crocetin can delay delays brain and body aging. Crocetin can be used for the researches of cancer, neurological disease and inflammation, such as cervical cancer and ischemia[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Transcrocetin; trans-Crocetin. CAS No. 27876-94-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2072. | |
| Crocetin dialdehyde | Crocetin dialdehyde is a non-volatile apocarotenoid obtained by the action of the plastidic enzyme CCD2 over the carotenoid zeaxanthin in saffron. Crocetin dialdehyde can be converted into Crocetin (HY-N2072) by aldehyde dehydrogenases (ALDHs). Crocetin dialdehyde has no effect on the liver in mice[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 502-70-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N10991. | |
| Crocin | Crocin (Crocin I) is an orally active natural product that can be isolated from the stigma of Crocus sativus. Crocin inhibits tumor cell proliferation and promotes apoptosis through JAK pathway. Crocin has anti-inflammatory, antioxidant and antitumor activities [1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Crocin I. CAS No. 42553-65-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0697. | |
| Crocin II | Crocin II is an inhibitor targeting α-synuclein aggregation, with a IC50 of 0.541 μM and a EC50 of 3.63 μM. Crocin II inhibits α-synuclein aggregation and dissociates pre-formed α-synuclein fibrils. Crocin II possesses antioxidant, anticancer and antidepressant activities. Crocin II is applicable to research related to neurological disorders such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy, as well as cancers[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 55750-84-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N0698. | |
| Crocin III | Crocin III is a crocin isolated from Crocus sativus L. Crocins inhibit the growth of tumor cells and exhibit anti-inflammatory activity[1][2][3]. Uses: Scientific research. Category: Natural products. CAS No. 55750-85-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N6644. | |
| Crocin (Standard) | Crocin (Standard) is the analytical standard of Crocin. This product is intended for research and analytical applications. Crocin (Crocin I) is an orally active natural product that can be isolated from the stigma of Crocus sativus. Crocin inhibits tumor cell proliferation and promotes apoptosis through JAK pathway. Crocin has anti-inflammatory, antioxidant and antitumor activities [1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Crocin I (Standard). CAS No. 42553-65-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0697R. | |
| Cromakalim | Cromakalim is a potassium channel opener. Cromakalim can be used as a bronchodilator in asthma. Cromakalim inhibits the spontaneous tone of human isolated bronchi in a concentration-related manner being nearly as effective as isoprenaline or theophylline[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BRL 34915. CAS No. 94470-67-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110011. | |
| Cromolyn | Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cromoglycate; Cromoglicic acid; FPL-670 free acid. CAS No. 16110-51-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1619. | |
| Cromolyn disodium | Cromolyn (Cromoglycate) disodium is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn disodium is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn disodium can be used in the research of bronchial asthma. In addition, Cromolyn disodium has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cromoglycate disodium; Cromoglicic acid disodium; FPL-670. CAS No. 15826-37-6. Pack Sizes: 10 mM * 1 mL in DMSO; 500 mg; 1 g; 5 g. Product ID: HY-B0320A. | |
| Cross-linked dextran G 200 | Cross-linked dextran G 200 is a hydrophilic gel based on molecular size exclusion and targeted macromolecular separation. Cross-linked dextran G 200 works through the gel permeation mechanism, and the cross-linked structure forms a three-dimensional network with a specific pore size, achieving separation based on the molecular hydrodynamic volume. Cross-linked dextran G 200 can be used to adjust the osmotic solute distribution coefficient and the ability to maintain osmotic equilibrium, such as in gel filtration chromatography for purification and analysis of biomacromolecules such as proteins and nucleic acids[1][2]. Cross-linked dextran G 200 can also be used as a gel filtration filler (particle size range: 40-120 μm; globular protein separation range: 5-600 kDa)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9041-36-5. Pack Sizes: 5 g; 10 g; 25 g. Product ID: HY-156045C. | |
| Cross-linked dextran G 50 | Cross-linked dextran G 50 is a gel filtration medium. Cross-linked dextran G 50 can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da)[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 9048-71-9. Pack Sizes: 5 g; 10 g; 25 g. Product ID: HY-138560. | |
| Cross-linked dextran G 75 | Cross-linked dextran G 75 is a Gel-filtration media. Cross-linked dextran G 75 also is a dextran-based matrix and used for Gel-filtration chromatography (Particle size range: 40-120 μm; Sphere protein separation range: 3K-80K Da; Polysaccharide separation range: 1K-50K Da)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 37224-29-6. Pack Sizes: 1 g; 5 g. Product ID: HY-148139. | |
| Crosstide | Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt. Uses: Scientific research. Category: Signaling pathways. CAS No. 171783-05-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P0315. | |
| Crotedumab | Crotedumab (REGN1193) is a fully human IgG4 monoclonal antibody that binds and inhibits glucagon receptor (GCGR), with a KD of 0.1 nM. Crotedumab can be used for the research of diabetes[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REGN1193; Anti-GCGR Reference Antibody (crotedumab). CAS No. 1452387-69-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99357. | |
| Crovalimab | Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2?nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SKY59; RO7112689; RG-6107. CAS No. 1917321-26-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99965. | |
| CRS3123 | CRS3123 is a potent and orally active narrow-spectrum antibiotic. CRS3123 inhibits bacterial methionyl-tRNA synthetase. CRS3123 has potent activity against Clostridium difficile (C. difficile) and aerobic Gram-positive bacteria but little activity against Gram-negative bacteria, including anaerobes. CRS3123 has the potential for the research of C. difficile infections[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: REP-3123. CAS No. 1013915-71-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18324. | |
| CRT0044876 | CRT0044876 is a potent and selective apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor (IC50=~3 μM). CRT0044876 inhibits the AP endonuclease, 3-phosphodiesterase and 3-phosphatase activities of APE1, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 6960-45-8. Pack Sizes: 10 mM * 1 mL in DMSO; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W014622. | |
| CRT0066101 | CRT0066101 is a potent and orally active PKD inhibitor with IC50 values of 1 nM, 2.5 nM and 2 nM for PKD1, PKD2, and PKD3, respectively[1]. CRT0066101 is also a potent PIM2 inhibitor with an IC50 of ~135.7?nM. CRT0066101 exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 956123-34-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-15698. | |
| CRT0066101 dihydrochloride | CRT0066101 dihydrochloride is a potent and orally active PKD inhibitor with IC50 values of 1 nM, 2.5 nM and 2 nM for PKD1, PKD2, and PKD3, respectively[1]. CRT0066101 dihydrochloride is also a potent PIM2 inhibitor with an IC50 of ~135.7?nM. CRT0066101 dihydrochloride exhibits anti-inflammatory activity in mice LPS (HY-D1056)-induced lung injury models, and has anticancer effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1883545-60-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15698A. | |
| CRT0066854 | CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCΙ, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1438881-19-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18713. | |
| CRT0066854 hydrochloride | CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCΙ, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2250019-91-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-18713A. | |
| CRT0273750 | CRT0273750 is an autotaxin (ATX) inhibitor and modulates LPA levels in plasm (IC50 = 0.014 μM). CRT0273750 can be used in ATX/LPA-dependent models of cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: IOA-289. CAS No. 1979939-16-6. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120797. | |
| Crustecdysone | Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP[1]. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system[2]. Crustecdysone is an active metabolite of Ecdysone (HY-N0179)[3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 20-Hydroxyecdysone. CAS No. 5289-74-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N6979. | |
| Cryptochlorogenic acid | Cryptochlorogenic acid (4-Caffeoylquinic acid) is a naturally occurring phenolic acid compound with oral effectiveness, anti-inflammatory, antioxidant and anti-cardiac hypertrophy effects. Alleviating LPS (HY-D1056) and ISO (HY-B0468) by regulating proinflammatory factor expression, inhibiting NF-κB activity, promoting Nrf2 nuclear transfer, and regulating PI3Kα/Akt/ mTOR / HIF-1α signaling pathway Induced physiological stress response[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 4-Caffeoylquinic acid; 4-O-Caffeoylquinic acid. CAS No. 905-99-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0787. | |
| (-)-Cryptopleurine | (-)-Cryptopleurine is an alkaloid that has been found in Lauraceae and has diverse biological activities. It inhibits the growth of human A375 melanoma, A431 epidermoid carcinoma, A549 lung, MES-SA uterine sarcoma, and MCF-7 breast cancer cells (IC50=3 nM for all).2 (-)-Cryptopleurine inhibits hypoxia-induced gene expression in a hypoxia response element (HRE) reporter assay (IC50=8.7 nM).3 (-)-Cryptopleurine (500 μg/mL) prevents lesion formation in tobacco (N. tabacum) plants infected with tobacco mosaic virus (TMV). It also inhibits protein synthesis by yeast and mammalian ribosomes. Uses: Scientific research. Category: Signaling pathways. Alternative Names: (R)-Cryptopleurine; NSC 19912. CAS No. 482-22-4. Pack Sizes: 1 mg. Product ID: HY-121255. | |
| Cryptotanshinone | Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cryptotanshinon; Tanshinone c. CAS No. 35825-57-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0174. | |
| Crystal Violet | Crystal Violet, also known as Gentian violet, methyl violet 10B, is a triphenyl-methane, an alkaline dye that binds to DNA in the nucleus of a cell, staining it a deep purple. It is often used for Gram staining to classify bacteria, or for cell or histological staining[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Basic Violet 3; Gentian Violet; Methyl Violet 10B. CAS No. 548-62-9. Pack Sizes: 500 mg; 5 g; 10 g. Product ID: HY-B0324A. | |
| Crystal Violet (solution) | Crystal Violet (solution) , also known as Gentian violet, methyl violet 10B, is a triphenyl-methane, an alkaline dye that binds to DNA in the nucleus of a cell, staining it a deep purple. It is often used for Gram staining to classify bacteria, or for cell or histological staining[1].Solvent and Concentration: Sterile water: 5 mg/mL (0.5%). Uses: Scientific research. Category: Signaling pathways. CAS No. 548-62-9. Pack Sizes: 100 mL. Product ID: HY-DY2001. | |
| CS587 | CS587 is a specific inhibitor of CaMK1D with neurocytotoxicity at 10 μM. CS587 modulates the sensitivity of neuronal cells to Aβ oligomer toxicity[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2388506-69-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148913. | |
| CS-6253 | CS-6253 is an agonist of ABCA1. CS-6253 can regulate lipoprotein metabolism, promote high-density lipoprotein biogenesis, and cellular cholesterol efflux. CS-6253 also has certain neuroprotective effects and can clear Aβ from the brain. CS-6253 can be used for research on cholesterol metabolism and diseases such as Alzheimers disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1627911-44-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P6306. | |
| CS640 | CS640 (Compound 19) is a chemical probe and a calmodulin-dependent kinase inhibitor. CS640 inhibits CaMK1D, CaMK1B, CaMK1A, CaMK1G, MEK5, RIPK4, mLK3 and PIP5K1, with IC50 values of 8, 3, 1, 1, 25 nM, 5.69, 2.75 and 11.2 μM, respectively. CS640 blocks Aβ-induced hyperphosphorylation of tau protein at the Thr181 site, but fails to protect primary mouse cortical neurons from Aβ-induced toxic damage. CS640 is applicable to research related to Alzheimer's disease[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2388506-83-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148907. | |
| CSF1R-IN-24 | CSF1R-IN-24 (Example 134) is an orally active CSF1R inhibitor. CSF1R-IN-24 significantly inhibits the survival of human ipSC-derived microglia (hiPSC-MG)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3024322-57-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160842. | |
| CSK-IN-1 | CSK-IN-1 (compound 13) is a potent, orally active c-terminal Src kinase (CSK) with IC50 values below 3 nM and 4 nM in CSK HTRF and Caliper assay, respectively. CSK-IN-1 shows the ability to increase T cell proliferation induced by T cell receptor signaling[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2380027-49-4. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130254. | |
| CSN5i-3 | CSN5i-3 is a potent, selective and orally available inhibitor of CSN5/Jab1, and inhibits CSN-catalysed Cul1 deneddylation with an IC50 value of 5.8 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2375740-98-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-112134. | |
| CSNK1-IN-1 | CSNK1-IN-1 is a CSNK1A1 inhibitor. CSNK1-IN-1 has inhibitory activity for CSNK1A1 kinase with IC50 values of 21 μM. CSNK1-IN-1 can be used for the research of proliferative disorders[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2468784-55-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148489. | |
| CSP1 | CSP1 is a potent and selective ComD1 receptor agonist, with an IC50 of 10.3 nM. CSP1 is a major variants of competence-stimulating peptide (CSP), and it can regulate genetic transformation of S. pneumonia by modulating quorum sensing (QS). CSP1 can act as an antibacterial agent[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 172889-49-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2454. | |
| CSRM617 hydrochloride | CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1353749-74-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122611A. | |
| CST530 | CST530 is an inhibitor of apoptosis protein (IAP) antagonist. CST530 is an IAP-type Ligands for E3 Ligase. CST530 binds to the BIR3 domain of IAP and interferes with its function, thereby promoting the ubiquitination and degradation of cIAP1. CST530 can be used to prepare PROTACs[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 847137-53-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-150825. | |
| CST626 | CST626 (Compound 9) is a pan-IAP degrader PROTAC. CST626 degrades XIAP, cIAP1 and cIAP2 with DC50s of 0.7, 2.4, and 6.2 nM in MM.1S cells, respectively[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3033993-13-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-149924. | |
| CST967 | CST967 (Compound 17) is a USP7 PROTAC degrader, and increasing the PROTAC concentration can enhance the degradation rate of USP7. CST967 can be used in cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3093667-09-2. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-160502. | |
| CT1113 | CT1113 is a selective, orally active USP25/USP28 inhibitor. CT1113 inhibits cancer cell proliferation, induces apoptosis, and causes G2/S phase cell cycle arrest. CT1113 reduces the levels of total BCR-ABL1, phosphorylated BCR-ABL1, total STAT5, and phosphorylated STAT5, but does not alter the mRNA level of BCR-ABL1. CT1113 is applicable to research related to pancreatic cancer, colon cancer, and acute leukemia[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2523435-18-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-153996. | |
| CT-179 | CT-179 is a brain-penetrant and orally active OLIG2 inhibitor with a human IC50 of 1250 nM. CT-179 disrupts OLIG2 dimerization, phosphorylation, and DNA binding, blocking OLIG2-driven transcription. CT-179 induces G2/M phase arrest and increases G0 population. CT-179 induces apoptosis by reducing anti-apoptotic proteins and increasing cleaved caspase-3 and cleaved PARP. CT-179 can be used for the research of subgroup medulloblastoma[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1996636-69-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-179078. | |
| CT-996 | CT-996 is an orally active GLP-1RA agonist with an EC50 of 0.49 nM. CT-996 reduces the recruitment of β-arrestin and the internalization of GLP-1R. CT-996 suppresses postprandial blood glucose in mice expressing human GLP-1 receptors and enhances glucose-stimulated insulin secretion (GSIS) in obese monkeys during intravenous glucose challenge. CT-996 can be used for the research of type 2 diabetes (T2D) and obesity[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: RO7795081; RG6652. CAS No. 2810808-95-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-175701. | |
| CTAP | CTAP is a potent, highly selective, and BBB penetrant μ opioid receptor antagonist, with an IC50 of 3.5 nM. CTAP displays over 1200-fold selectivity over δ opioid (IC50=4500 nM) and somatostatin receptors. CTAP can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 103429-32-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1335. | |
| CTB | CTB is a potent p300 histone acetyltransferase activator[1]. CTB can effectively induce apoptosis in MCF-7 cells[2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 451491-47-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134964. | |
| CTCE-0214 | CTCE-0214 is a chemokine CXC receptor 4 (CXCR4) agonist, SDF-1α (stromal cell-derived factor-1α) peptide analog. CTCE-0214 shows anti-inflammatory activity, and can be used in inflammation sepsis and systemic inflammatory syndromes research[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 577782-52-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3612. | |
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