MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Cyclic-di-GMP disodium | Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: c-di-GMP disodium; cyclic diguanylate disodium; 5GP-5GP disodium. CAS No. 2222132-40-1. Pack Sizes: 10 mM * 1 mL in Water; 1 mg; 5 mg; 10 mg. Product ID: HY-110382. |  |
| Cyclic GMP | Cyclic GMP (cGMP), an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 7665-99-8. Pack Sizes: 10 mM * 1 mL in Water; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-113469. | |
| Cyclic PSAP peptide | Cyclic PSAP peptide is a cyclic pentapeptide (DWLPK). Cyclic PSAP peptide exhibits agent-like properties and could inhibit metastatic spread and restrain tumor development in general in vivo[1]. Uses: Scientific research. Category: Peptides. CAS No. 1810853-35-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4102. | |
| Cyclic somatostatin | Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: SRIF-14; Somatostatin-14. CAS No. 38916-34-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0084. | |
| Cyclin K degrader 1 | Cyclin K degrader 1 (compound 40) is an AT7519 (HY-50940) based Cyclin K degrader with DC50 of 21 nM. Cyclin K degrader 1 has an affinity for cyclin K that is ~500-fold higher than its affinity for CDK12[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3055008-98-2. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-161168. | |
| Cyclizine | Cyclizine, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine can be used for the research of nausea, vomiting, and dizziness[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 82-92-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1397. | |
| Cyclo(Ala-?Pro) | Cyclo(Ala-Pro) is an anticancer agent that is toxic to cancer cells such as A549, HCT-116 and HepG2[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 36357-32-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1935. | |
| Cyclo(Arg-Gly-Asp-D-Phe-Cys) | Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cyclo(RGDfC). CAS No. 862772-11-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P2300. | |
| Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) | Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) c(RGDfE) is a cyclic RGD peptide targeting integrin αvβ3. Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) is commonly used for modifying drug loaded nanoparticles. Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) is often used in cancer research, such as pancreatic cancer[1][2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: c(RGDfE). CAS No. 756500-22-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P5021. | |
| Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] | Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is the derivative of Cyclo(-RGDfK) (HY-P0023). Cyclo[Arg-Gly-Asp-D-Phe-Lys(Azide)] is a click chemistry reagent containing an azide group. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cyclo[RGDfK(Azide)]. CAS No. 2767993-86-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10303. | |
| Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA | Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (Cyclo(RGDfV) (TFA))is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cyclo(RGDfV) TFA; C(RGDfV) TFA. CAS No. 199807-33-5. Pack Sizes: 5 mg. Product ID: HY-P1613A. | |
| Cyclo(Arg-Pro) | Cyclo(Arg-Pro) (Cyclo(Pro-Arg)) is an inhibitor for chitinase. Cyclo(Arg-Pro) inhibits cell separation of Saccharomyces cerevisiae, without affecting its growth. Cyclo(Arg-Pro) inhibits the morphological change of Candida albicans from yeast form to filamentous form[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cyclo(Pro-Arg). CAS No. 74838-83-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P10304. | |
| Cycloartenol | Cycloartenol, a phytosterol compound, is one of the key precusor substances for biosynthesis of numerous sterol compounds. Cycloartenol inhibits the migration of glioma cells and suppresses the phosphorylation of the p38 MAP kinase. Cycloartenol has a variety of pharmacological activities such as anti-inflammatory, anti-tumor, antioxidant, antibiosis and anti-alzheimer's disease. Cycloartenol also plays an important role in the process of plant growth and development[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 469-38-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N7255. | |
| Cycloartenyl ferulate | Cycloartenyl ferulate (Cycloartenol ferulate; Cycloartenol ferulic acid ester) is a derivative of γ-oryzanol (HY-B2194) with multiple biological activities including antioxidant, anti-inflammatory, and anti-tumor properties. Cycloartenyl ferulate selectively binds to IFNγR1 (binding affinity Kd = 0.5 μM) to activate the canonical JAK1/2-STAT1 signaling pathway. Cycloartenyl ferulate inhibits paraquat (PQ)-triggered apoptosis and ROS in HK2 cells. Cycloartenyl ferulate enhances the activation and cytolytic activity of natural killer (NK) cells by upregulating the expression of NK cell activation receptors (NKG2D, NKp30, NKp44) and the release of cytotoxic molecules and cytokine IFNγ. Cycloartenyl ferulate exerts anti-cancer effects in tumor mice models. Cycloartenyl ferulate can be used for the study of cancer and allergic inflammation intervention[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cycloartenol ferulate; Cycloartenol ferulic acid ester. CAS No. 21238-33-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-125938. | |
| Cycloastragenol | Cycloastragenol (Astramembrangenin), the active form of astragaloside IV, has anti-oxidant, anti-inflammatory, anti-aging, anti-apoptotic, and cardiovascular protective effects. Cycloastragenol is a potent telomerase activator and can lengthen telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Astramembrangenin; Cyclosieversigenin. CAS No. 78574-94-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N1485. | |
| Cyclobenzaprine hydrochloride | Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT2 receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: MK130 hydrochloride. CAS No. 6202-23-9. Pack Sizes: 10 mM * 1 mL in DMSO; 1 g; 5 g. Product ID: HY-B0740. | |
| cyclo(CLLFVY) | cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1446322-73-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P10426. | |
| Cyclocreatine | Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimers disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer[1][2][3][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 35404-50-3. Pack Sizes: 10 mM * 1 mL in Water; 100 mg. Product ID: HY-W017540. | |
| Cyclo(Ile-Leu) | Cyclo(Ile-Leu) is a Alkaloids product that can be isolated from From Penicillium oxalicum[1]. Uses: Scientific research. Category: Natural products. CAS No. 91741-17-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N11955. | |
| Cyclo(IP) | Cyclo(IP) (Cyclo-(L-Pro-L-Ile)), a Diketopiperazine can be derived From Bacillus thuringiensis JCK-1233, results in suppression of PWD severity and increased the expression of defense-related genes similarly to Bacillus thuringiensis JCK-1233 treatment[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cyclo(L-Pro-L-Ile). CAS No. 57089-60-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P3472. | |
| Cyclo(L-Leu-L-Pro) | Cyclo(L-Leu-L-Pro) is a cyclic dipeptide with broad-spectrum antibacterial, antiviral and antifungal activities. Its biological activity is highly dependent on the stereoconfiguration and is widely present in microbial metabolites. Cyclo(L-Leu-L-Pro) efficiently and specifically inhibits the production of aflatoxin by Aspergillus flavus. The cis configuration of Cyclo(L-Leu-L-Pro) (cis-cyclo(L-Leu-L-Pro)) has broad-spectrum antibacterial activity against multi-drug resistant bacteria and significantly inhibits the influenza A virus H3N2[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cyclo(L-prolyl-L-leucyl). CAS No. 2873-36-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P1939. | |
| Cyclo(L-Phe-L-Pro) | Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide[1]. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation[2]. Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 μM in the DPPH assay[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 3705-26-8. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-P1934A. | |
| Cyclo(L-Trp-L-Trp) | Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 20829-55-4. Pack Sizes: 50 mg; 100 mg. Product ID: HY-P2124. | |
| Cyclooxygenase 1, sheep | Cyclooxygenase 1, sheep (COX-1) is a 71 kDa membrane bound protein predominantly present in endoplasmic reticulum. Cyclooxygenase 1 has three domains, the epidermal growth factor (EGF) like domain, enzymatic and membrane binding domain. Cyclooxygenase 1 mediates prostaglandin synthesis and is modulated by anti-inflammatory nonsteroidal drugs[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: COX-1. CAS No. 329967-85-3. Pack Sizes: 1 KU. Product ID: HY-E70229. | |
| Cyclopamine | Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor. Uses: Scientific research. Category: Signaling pathways. Alternative Names: 11-Deoxojervine. CAS No. 4449-51-8. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-17024. | |
| (-)-Cyclopenol | (-)-Cyclopenol is a fungal metabolite isolated from an Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) [1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 20007-85-6. Pack Sizes: 1 mg. Product ID: HY-121133. | |
| Cyclopentenyl uracil | Cyclopentenyl uracil, a non-cytotoxic inhibitor of uridine kinase, effectively blocks the salvage of circulating uridine by host and tumor tissues in the intact mouse[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 90597-20-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-145668. | |
| Cyclo(Phe-Pro) | Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo(Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo(Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cyclo(phenylalanylprolyl); A-64863. CAS No. 14705-60-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1934. | |
| Cyclophosphamide | Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant. Uses: Scientific research. Category: Induced disease models products. CAS No. 50-18-0. Pack Sizes: 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-17420. | |
| Cyclophosphamide hydrate | Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Cyclophosphamide monohydrate. CAS No. 6055-19-2. Pack Sizes: 100 mg; 500 mg; 1 g. Product ID: HY-17420A. | |
| Cyclopiazonic acid | Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC50 value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B[1][4][5]. Uses: Scientific research. Category: Signaling pathways. CAS No. 18172-33-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg. Product ID: HY-N6771. | |
| Cyclo-(Pro-Gly) | Cyclo-(Pro-Gly) (Pyrrolopiperazine-2,5-dione), an alkaloid isolated from green algae Ulva prolifera, possesses antialgal activity against the common harmful red tide microalgae[1]. Cyclo-(Pro-Gly) (Pyrrolopiperazine-2,5-dione) possesses antiamnesic effects and neuroprotective actions[2]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Pyrrolopiperazine-2,5-dione. CAS No. 19179-12-5. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 1 g. Product ID: HY-W062171. | |
| Cyclopropaneacetamide-Exatecan | Cyclopropaneacetamide-Exatecan is an Exatecan (HY-13631) analogue and an ADC Cytotoxin. Cyclopropaneacetamide-Exatecan can be used to synthesize ADC molecules for cancer research[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2414254-36-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156617. | |
| Cyclo(Pro-Pro) | Cyclo(Pro-Pro) is a Alkaloids product that can be isolated from From Nigrospora sp.Z18-17[1]. Uses: Scientific research. Category: Natural products. CAS No. 6708-6-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-115820. | |
| Cyclo(RADfK) | Cyclo(RADfK) can be used as a control for Cyclo(-RGDfK) (HY-P0023)[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 756500-23-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P0031. | |
| Cyclo(-RGDfK) | Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 161552-03-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P0023. | |
| Cyclo(RGDfK(Mal)) | Cyclo(RGDfK(Mal)) is a pentapeptide. Cyclo(RGDfK(Mal)) improves the attachment and infiltration of human pluripotent stem cells. Cyclo(RGDfK(Mal)) can be used for 3D stem cell culture and expansion[1]. Uses: Scientific research. Category: Peptides. CAS No. 1228992-90-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P4047. | |
| Cyclo(RGDyK) | Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM. Uses: Scientific research. Category: Signaling pathways. CAS No. 217099-14-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100563A. | |
| cyclo(RLsKDK) | cyclo(RLsKDK) (BK-1361) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. cyclo(RLsKDK) has potential applications in inflammatory diseases and cancer[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: BK-1361. CAS No. 1975145-82-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1676. | |
| Cyclosomatostatin | Cyclosomatostatin is a potent somatostatin (SST) receptor antagonist. Cyclosomatostatin can inhibit somatostatin receptor type 1 (SSTR1) signaling and decreases cell proliferation, ALDH+ cell population size and sphere-formation in colorectal cancer (CRC) cells[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 84211-54-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1201. | |
| Cyclosporin | Cyclosporin is a cyclic decapeptide that could be isolated form the soil fungi Tolypocladium inflatum. Cyclosporin is an immunosuppressant thought to bind to cyclophilin in T-lymphocytes[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 79217-60-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100731. | |
| Cyclosporin A | Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM[3]. Cyclosporin A also inhibits CD11a/CD18 adhesion[8]. Uses: Scientific research. Category: Induced disease models products. Alternative Names: Cyclosporine A; Ciclosporin A; CsA. CAS No. 59865-13-3. Pack Sizes: 10 mM * 1 mL in DMSO; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-B0579. | |
| Cyclosporin A (Standard) | Cyclosporin A (Standard) is the analytical standard of Cyclosporin A. This product is intended for research and analytical applications. Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM[3]. Cyclosporin A also inhibits CD11a/CD18 adhesion[8]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cyclosporine A (Standard); Ciclosporin A (Standard); CsA (Standard). CAS No. 59865-13-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0579R. | |
| Cyclosporin B | Cyclosporin B is a group of nonpolar cyclic oligopeptides with immunosuppressive activity. Cyclosporin B is used for the prevention of graft rejection in organ transplantation[1]. Uses: Scientific research. Category: Peptides. CAS No. 63775-95-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1973. | |
| Cyclosporin D | Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A[1][2]. Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc)[3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 63775-96-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W019721. | |
| Cyclosporin G | Cyclosporin G is an active metabolite that can be produced from Tolypocladium inflatum. Cyclosporin G has immunosuppressive activity. Cyclosporin G inhibits proliferation of A431 cells[1][2]. Uses: Scientific research. Category: Peptides. CAS No. 74436-00-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-105023. | |
| Cyclosporin H | Cyclosporin H is a selective and potent inhibitor of FPR-1 (formyl peptide receptor 1). Cyclosporin H, a viral transduction enhancer, increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Cyclosporin H displays an additive effect when combined with Rapamycin (HY-10219) or Prostaglandin E2 (HY-101952). Cyclosporin H lacks immunosuppressant activity of Cyclosporin A. Uses: Scientific research. Category: Signaling pathways. CAS No. 83602-39-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1122. | |
| Cyclothiazide | Cyclothiazide is a positive allosteric modulator of ionotropic AMPA-type glutamate receptors. Cyclothiazide inhibits GABAA receptors. Cyclothiazide is frequently used to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. Cyclothiazide can potentiate responses to kainate in hippocampal neurons. Cyclothiazide has effects on glutamatergic neurotransmission. Cyclothiazide also induces epileptiform EEG activity accompanying behavioral seizures[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 2259-96-3. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101165. | |
| Cyclotraxin B | Cyclotraxin B is a BBB-penetrable and selective TrkB inhibitor. Cyclotraxin B inhibits BDNF-induced TrkB activity in a non-competitive manner, with an IC50 of 0.30 nM. Cyclotraxin B has analgesic and anxiolytic effects[1][2][3]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1203586-72-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1178. | |
| Cyclotriazadisulfonamide | Cyclotriazadisulfonamide (CADA) is a specific CD4-targeted HIV entry inhibitors. Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way. Cyclotriazadisulfonamide is also a Sec61 translocon inhibitor[1][2][3]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: CADA. CAS No. 182316-44-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134809. | |
| CycLuc1 | CycLuc1 is a blood-brain barrier permeable luciferase substrate that displays near-infrared (NIR) emission with a peak luminescence wavelength of 599 nm. CycLuc1 can be used for in vivo bioluminescence imaging[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1247879-16-8. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111653. | |
| CYD19 | CYD19 is a potent Snail/HDAC dual target inhibitor. CYD19 displays potent inhibitory activity against HDAC1 with an IC50 of 0.405 μM and potent inhibition against Snail with a Kd of 0.18 μM. CYD19 increases histone H4 acetylation in HCT-116 cells and decreases the expression of Snail protein to induce cell apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Snail/HDAC-IN-1. CAS No. 2415281-52-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-144315. | |
| CYD-4-61 | CYD-4-61 is a novel Bax activator used for breast cancer research. CYD-4-61 inhibits triple-negative breast cancer MDA-MB-231 and ER-positive breast cancer MCF-7 cell lines proliferation. CYD-4-61 activates Bax protein to induce cytochrome c release and regulate apoptotic biomarkers, leading to cancer cell apoptosis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1425944-33-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148368. | |
| Cyflumetofen | Cyflumetofen is a synthetic miticide that strongly inhibits mitochondrial complex II of spider mites, but not of insects, crustaceans, or mammals. Cyflumetofen is not significantly effective in inhibiting aflatoxin production in fungi[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 400882-07-7. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-W663938. | |
| Cyhalofop-butyl | Cyhalofop-butyl is a post-emergence herbicide. Cyhalofop-butyl inhibits acetyl-coenzyme A carboxylase (ACCase) biosynthesis[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 122008-85-9. Pack Sizes: 10 mM * 1 mL in DMSO; 50 mg; 100 mg. Product ID: HY-B0861. | |
| Cylindrospermopsin | Cylindrospermopsin, a cyanotoxin, is a polycyclic uracil derivative containing guanidine and sulfate groups, which can inhibit protein synthesis and covalently modify DNA or RNA. Cylindrospermopsin induces hepatocellular hypertrophy, renal cellular hypertrophy, intracellular reactive oxygen species (ROS), DNA strand breaks, mitochondrial hyperpolarisation, ultrastructural damage, and altered gene expression in liver, kidney, and intestinal cells. Cylindrospermopsin can be used in research including hepatocellular carcinoma and water quality testing[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 143545-90-8. Pack Sizes: 50 μg; 100 μg; 500 μg. Product ID: HY-121360. | |
| CYM2503 | CYM2503 is a putative GalR2-positive allosteric modulator. CYM2503 increases the latency to first electrographic seizure and decreases the total time in seizure. CYM2503 also attenuates electroshock-induced seizures in mice. Galanin receptors type 1 (GalR1) and/or type 2 (GalR2) represent unique pharmacological targets for the research of seizures and epilepsy[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1308833-36-4. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-123671. | |
| CYM50260 | CYM50260 is a potent and exquisitely selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonist with an EC50 of 45 nM. CYM50260 displays no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1355026-60-6. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg. Product ID: HY-108494. | |
| CYM50308 | CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. CYM50308 displays 37-fold more selective for S1P4-R than S1P5-R. CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM[1]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ML248. CAS No. 1345858-76-5. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108495. | |
| CYM50358 | CYM50358 is a potent and selective S1PR4 antagonist, with an IC50 of 25 nM. CYM50358 can be used for the research of influenza infection[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1314212-39-9. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136462. | |
| CYM 50769 | CYM 50769 is a non-peptidic selective antagonist of neuropeptides B and W receptor 1 (NPBWR1). CYM 50769 can attenuates the NPW-23-induced cell proliferation in ATDC5. CYM 50769 can be used for researching endochondral bone formation[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1421365-63-0. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108624. | |
| CYM-5478 | CYM-5478 is a potent and highly selective S1P2 agonist with an EC50 of 119 nM in a TGFα-shedding assay. CYM-5478 protects neural-derived cell lines against Cisplatin toxicity[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 870762-83-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111253. | |
| CYM-5520 | CYM-5520 is a selective and allosteric sphingosine 1-phosphate receptor 2 (S1PR2) agonist with an EC50 of 480 nM. CYM-5520 does not activate S1PR1, S1PR3, S1PR4 and S1PR5 receptors. CYM-5520 can co-bind in the S1PR2 receptor with S1P. CYM-5520 can be used for osteoporosis research[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1449747-00-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100953. | |
| CYM-5541 | CYM-5541 (ML249) is an selective and allosteric S1P3 receptor agonist with an EC50 between 72 and 132 nM. Uses: Scientific research. Category: Signaling pathways. Alternative Names: ML249. CAS No. 945128-26-7. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101419. | |
| CYM 9484 | CYM 9484 is a selective and highly potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM[1]. Uses: Scientific research. Category: Signaling pathways. CAS No. 1383478-94-1. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107735. | |
| Cymarin | Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K+ release (IC50=0.42 μM). Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant[1][2][3][4]. Uses: Scientific research. Category: Signaling pathways. CAS No. 508-77-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-111934. | |
| CYN 154806 | CYN 154806, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC50 values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively[1][2]. Uses: Scientific research. Category: Signaling pathways. CAS No. 183658-72-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1202. | |
| Cynarin | Cynarin is an antichoke agent with a variety of biological activities including antioxidant, antihistamic and antiviral activities. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Cynarine. CAS No. 30964-13-7. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0359. | |
| Cynaropicrin | Cynaropicrin is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling. Uses: Scientific research. Category: Signaling pathways. CAS No. 35730-78-0. Pack Sizes: 10 mM * 1 mL in DMSO; 1 mg; 5 mg; 10 mg. Product ID: HY-N2350. | |
| Cynaroside | Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. Cynaroside also is a promising inhibitor for H2O2-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities[1][3][4][5]. Uses: Scientific research. Category: Signaling pathways. Alternative Names: Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside. CAS No. 5373-11-5. Pack Sizes: 10 mM * 1 mL in DMSO; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0540. | |
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